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https://www.readbyqxmd.com/read/28444476/assessing-the-dim-light-melatonin-onset-in-adults-with-autism-spectrum-disorder-and-no-comorbid-intellectual-disability
#1
Emma K Baker, Amanda L Richdale, Agnes Hazi, Luke A Prendergast
This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters. Sixteen adults with ASD (ASD-Only), 12 adults with ASD medicated for comorbid diagnoses of anxiety and/or depression (ASD-Med) and 32 controls participated in the study. Although, the timing of the DLMO did not differ between the two groups, advances and delays of the melatonin rhythm were observed in individual profiles...
April 26, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28405608/circadian-phase-resetting-by-a-single-short-duration-light-exposure
#2
Shadab A Rahman, Melissa A St Hilaire, Anne-Marie Chang, Nayantara Santhi, Jeanne F Duffy, Richard E Kronauer, Charles A Czeisler, Steven W Lockley, Elizabeth B Klerman
BACKGROUND. In humans, a single light exposure of 12 minutes and multiple-millisecond light exposures can shift the phase of the circadian pacemaker. We investigated the response of the human circadian pacemaker to a single 15-second or 2-minute light pulse administered during the biological night. METHODS. Twenty-six healthy individuals participated in a 9-day inpatient protocol that included assessment of dim light melatonin onset time (DLMO time) before and after exposure to a single 15-second (n = 8) or 2-minute (n = 12) pulse of bright light (9,500 lux; 4,100 K fluorescent) or control background dim light (<3 lux; n = 6)...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28364493/effects-of-melatonin-and-bright-light-treatment-in-childhood-chronic-sleep-onset-insomnia-with-late-melatonin-onset-a-randomized-controlled-study
#3
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Kristiaan B van der Heijden, Frans J Oort
Study Objectives: Chronic sleep onset insomnia with late melatonin onset is prevalent in childhood, and has negative daytime consequences. Melatonin treatment is known to be effective in treating these sleep problems. Bright light therapy might be an alternative treatment, with potential advantages over melatonin treatment. In this study, we compare the effects of melatonin and bright light treatment with a placebo condition in children with chronic sleep onset insomnia and late melatonin onset...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364473/prevalence-of-circadian-misalignment-and-its-association-with-depressive-symptoms-in-delayed-sleep-phase-disorder
#4
Jade M Murray, Tracey L Sletten, Michelle Magee, Christopher Gordon, Nicole Lovato, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha M W Rajaratnam
Study Objective: To examine the prevalence of circadian misalignment in clinically diagnosed delayed sleep phase disorder (DSPD) and to compare mood and daytime functioning in those with and without a circadian basis for the disorder. Methods: One hundred and eighty-two DSPD patients aged 16-64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO)...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28327443/correcting-delayed-circadian-phase-with-bright-light-therapy-predicts-improvement-in-adhd-symptoms-a-pilot-study
#5
Rachel E Fargason, Aaron D Fobian, Lauren M Hablitz, Jodi R Paul, Brittny A White, Karen L Cropsey, Karen L Gamble
Attention-deficit/hyperactivity disorder (ADHD) is a common condition with comorbid insomnia reported in >70% of children and adults. These patients demonstrate delays in sleep-wake rhythms, nocturnal rise in melatonin, and early morning rise in cortisol. Given that standard psychopharmacologic treatments for ADHD often do not completely control symptoms in participants with circadian rhythm delay, we sought to test whether bright light therapy (BLT) advances circadian rhythms and further reduces ADHD symptoms over standard treatments...
March 6, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28285255/relationships-between-circadian-measures-depression-and-response-to-antidepressant-treatment-a-preliminary-investigation
#6
Leslie M Swanson, Helen J Burgess, Edward D Huntley, Holli Bertram, Ann Mooney, Jennifer Zollars, Richard Dopp, Robert Hoffmann, Roseanne Armitage, J Todd Arnedt
Few studies have examined relationships between circadian rhythms and unipolar major depressive disorder. Further, no study to date has examined circadian markers as predictors of response to depression treatment. In the present study, we examined associations between circadian timing and its alignment with sleep and depression severity in 30 adults with major depressive disorder who completed a randomized controlled trial of two weeks of time in bed (TIB) restriction administered adjunctive to fluoxetine, with a focus on sex differences...
March 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28245865/can-tryptophan-supplement-intake-at-breakfast-enhance-melatonin-secretion-at-night
#7
Shunsuke Nagashima, Makoto Yamashita, Chiaki Tojo, Masayuki Kondo, Takeshi Morita, Tomoko Wakamura
BACKGROUND: Tryptophan (TRP) is an essential amino acid, and it has been suggested that TRP intake at breakfast combined with daytime bright light exposure can increase nocturnal melatonin secretion. However, the mechanisms involved are not yet clear. The aim of this study was to examine the effect of TRP supplement intake at breakfast on nocturnal melatonin secretion under different daytime light intensities in humans. METHOD: Twelve subjects (aged 21.3 ± 3...
February 28, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28042611/bedtime-and-evening-light-exposure-influence-circadian-timing-in-preschool-age-children-a-field-study
#8
Lameese D Akacem, Kenneth P Wright, Monique K LeBourgeois
Light exposure and sleep timing are two factors that influence inter-individual variability in the timing of the human circadian clock. The aim of this study was to quantify the degree to which evening light exposure predicts variance in circadian timing over and above bedtime alone in preschool children. Participants were 21 children ages 4.5-5.0 years (4.7 ± 0.2 years; 9 females). Children followed their typical sleep schedules for 4 days during which time they wore a wrist actigraph to assess sleep timing and a pendant light meter to measure minute-by-minute illuminance levels in lux...
November 2016: Neurobiology of Sleep and Circadian Rhythms
https://www.readbyqxmd.com/read/27797990/cohort-profile-the-baependi-heart-study-a-family-based-highly-admixed-cohort-study-in-a-rural-brazilian-town
#9
Kieren J Egan, Malcolm von Schantz, André B Negrão, Hadassa C Santos, Andréa R V R Horimoto, Nubia E Duarte, Guilherme C Gonçalves, Júlia M P Soler, Mariza de Andrade, Geraldo Lorenzi-Filho, Homero Vallada, Tâmara P Taporoski, Mario Pedrazzoli, Ana P Azambuja, Camila M de Oliveira, Rafael O Alvim, José E Krieger, Alexandre C Pereira
PURPOSE: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits...
October 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27795550/circadian-timing-and-alignment-in-healthy-adults-associations-with-bmi-body-fat-caloric-intake-and-physical-activity
#10
K G Baron, K J Reid, T Kim, L Van Horn, H Attarian, L Wolfe, J Siddique, G Santostasi, P C Zee
INTRODUCTION: Disruption of circadian rhythms is one of the proposed mechanisms linking late sleep timing to obesity risk but few studies have evaluated biological markers outside of the laboratory. The goal of this study was to determine the relationship between the timing and alignment of melatonin and sleep onset (phase angle) with body mass index (BMI), body fat and obesity-related behaviors. We hypothesized that circadian alignment (relationship of melatonin to sleep timing) rather than circadian (melatonin) timing would be associated with higher BMI, body fat, dietary intake and lower physical activity...
February 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27748241/effects-of-melatonin-and-bright-light-treatment-in-childhood-chronic-sleep-onset-insomnia-with-late-melatonin-onset-a-randomised-controlled-study
#11
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Kristiaan B van der Heijden, Frans J Oort
STUDY OBJECTIVES: Chronic sleep onset insomnia with late melatonin onset is prevalent in childhood, and has negative daytime consequences. Melatonin treatment is known to be effective in treating these sleep problems. Bright light therapy might be an alternative treatment, with potential advantages over melatonin treatment. In this study, we compare the effects of melatonin and bright light treatment with a placebo condition in children with chronic sleep onset insomnia and late melatonin onset...
October 10, 2016: Sleep
https://www.readbyqxmd.com/read/27692277/sleep-and-melatonin-secretion-abnormalities-in-children-and-adolescents-with-fetal-alcohol-spectrum-disorders
#12
Shery Goril, Dora Zalai, Louise Scott, Colin M Shapiro
OBJECTIVES: Caregivers describe significant sleep disturbances in the vast majority of children and adolescents, which is diagnosed as fetal alcohol spectrum disorders (FASD), but objective data on sleep disorders in this population are almost completely lacking. Animal models suggest that intrauterine alcohol exposure may disrupt sleep wake patterns, cause sleep fragmentation, and specifically affect the suprachiasmatic nucleus, thus disrupting melatonin secretion. The objective of this pioneering study was to evaluate sleep and melatonin abnormalities in children with FASD using objective, gold-standard measures...
July 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27692050/prevalence-of-circadian-misalignment-and-its-association-with-depressive-symptoms-in-delayed-sleep-phase-disorder
#13
Jade M Murray, Tracey L Sletten, Michelle Magee, Christopher Gordon, Nicole Lovato, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha M W Rajaratnam
STUDY OBJECTIVE: To examine the prevalence of circadian misalignment in clinically diagnosed DSPD, and compare mood and daytime functioning in those with and without a circadian basis for the disorder. METHODS: 182 DSPD patients aged 16 to 64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO). Based on the DLMO assessments, patients were classified into two groups: circadian DSPD, defined as DLMO occurring at or after desired bedtime, or non-circadian DSPD, defined as DLMO occurring before desired bedtime...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27611743/can-the-circadian-phase-be-estimated-from-self-reported-sleep-timing-in-patients-with-delayed-sleep-wake-phase-disorder-to-guide-timing-of-chronobiologic-treatment
#14
Nicole Lovato, Gorica Micic, Michael Gradisar, Sally A Ferguson, Helen J Burgess, David J Kennaway, Leon Lack
INTRODUCTION: The efficacy of bright light and/or melatonin treatment for Delayed Sleep Wake Phase Disorder (DSWPD) is contingent upon an accurate clinical assessment of the circadian phase. However, the process of determining this circadian phase can be costly and is not yet readily available in the clinical setting. The present study investigated whether more cost-effective and convenient estimates of the circadian phase, such as self-reported sleep timing, can be used to predict the circadian phase and guide the timing of light and/or melatonin treatment (i...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27566781/scheduled-evening-sleep-and-enhanced-lighting-improve-adaptation-to-night-shift-work-in-older-adults
#15
Evan D Chinoy, Michael P Harris, Min Ju Kim, Wei Wang, Jeanne F Duffy
OBJECTIVES: We tested whether a sleep and circadian-based treatment shown to improve circadian adaptation to night shifts and attenuate negative effects on alertness, performance and sleep in young adults would also be effective in older adults. METHODS: We assessed subjective alertness, sustained attention (psychomotor vigilance task, PVT), sleep duration (actigraphy) and circadian timing (salivary dim-light melatonin onset, DLMO) in 18 older adults (57.2±3.8 years; mean±SD) in a simulated shift work protocol...
December 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27530460/impact-of-sleep-behavior-on-glycemic-control-in-type-1-diabetes-the-role-of-social-jetlag
#16
Sandra Larcher, Anne-Sophie Gauchez, Sandrine Lablanche, Jean-Louis Pépin, Pierre-Yves Benhamou, Anne-Laure Borel
BACKGROUND: Sleep behavior is changing toward shorter sleep duration and a later chronotype. It results in a sleep debt that is acquitted on work-free days, inducing a small but recurrent sleep misalignment each week, referred to as "social jetlag". These sleep habits could affect health through misalignment with circadian rhythms. OBJECTIVES: The primary objective is to address the impact of sleep behavior on glycemic control, assessed by HbA1c, in patients with type 1 diabetes, independently of other lifestyle or sleep-related factors...
November 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27384816/the-effect-of-cataract-surgery-on-salivary-melatonin-and-sleep-quality-in-aging-people
#17
Yan Shenshen, Wang Minshu, Yuan Qing, Liu Yang, Zhai Suodi, Wang Wei
Blue light plays an important role in circadian photoentrainment by stimulating the melanopsin-expressing photosensitive retinal ganglion cells. Age-related cataract causes progressive loss of blue light transmission, which may lead to changes in circadian rhythm and sleep quality. In theory, increased light transmission by cataract surgery may improve circadian misalignment and sleep quality, while the effect of cataract surgery on circadian rhythm is not well understood. In this study, we assessed 30 binocular age-related nuclear cataract patients (aged 72...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27344501/circadian-phase-typing-in-idiopathic-generalized-epilepsy-dim-light-melatonin-onset-and-patterns-of-melatonin-secretion-semicurve-findings-in-adult-patients
#18
Raffaele Manni, Roberto De Icco, Riccardo Cremascoli, Giulia Ferrera, Francesca Furia, Elena Zambrelli, Maria Paola Canevini, Michele Terzaghi
OBJECTIVE/BACKGROUND: It has been debated in the literature whether patients with idiopathic generalized epilepsy (IGE) have a distinctive, evening-oriented chronotype. The few questionnaire-based studies that are available in the literature have conflicting results. The aim of our study was to define chronotype in patients with IGE by determining dim light melatonin onset (DLMO). PATIENTS/METHODS: Twenty adults diagnosed with IGE (grand mal on awakening [GM] in 7 cases and juvenile myoclonic epilepsy in 13 cases) were investigated by means of a face-to-face semistructured sleep interview, Morningness-Eveningness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI) questionnaire, and a melatonin salivary test with DLMO determination...
August 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27322730/wearing-blue-light-blocking-glasses-in-the-evening-advances-circadian-rhythms-in-the-patients-with-delayed-sleep-phase-disorder-an-open-label-trial
#19
Yuichi Esaki, Tsuyoshi Kitajima, Yasuhiro Ito, Shigefumi Koike, Yasumi Nakao, Akiko Tsuchiya, Marina Hirose, Nakao Iwata
It has been recently discovered that blue wavelengths form the portion of the visible electromagnetic spectrum that most potently regulates circadian rhythm. We investigated the effect of blue light-blocking glasses in subjects with delayed sleep phase disorder (DSPD). This open-label trial was conducted over 4 consecutive weeks. The DSPD patients were instructed to wear blue light-blocking amber glasses from 21:00 p.m. to bedtime, every evening for 2 weeks. To ascertain the outcome of this intervention, we measured dim light melatonin onset (DLMO) and actigraphic sleep data at baseline and after the treatment...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27318227/estimating-the-dim-light-melatonin-onset-of-adolescents-within-a-6-h-sampling-window-the-impact-of-sampling-rate-and-threshold-method
#20
Stephanie J Crowley, Christina Suh, Thomas A Molina, Louis F Fogg, Katherine M Sharkey, Mary A Carskadon
OBJECTIVE/BACKGROUND: Circadian rhythm sleep-wake disorders (CRSWDs) often manifest during the adolescent years. Measurement of circadian phase such as the dim light melatonin onset (DLMO) improves diagnosis and treatment of these disorders, but financial and time costs limit the use of DLMO phase assessments in clinic. The current analysis aims to inform a cost-effective and efficient protocol to measure the DLMO in older adolescents by reducing the number of samples and total sampling duration...
April 2016: Sleep Medicine
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