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Circadian cognition

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https://www.readbyqxmd.com/read/28649997/characterizing-sleep-spindles-in-11-630-individuals-from-the-national-sleep-research-resource
#1
S M Purcell, D S Manoach, C Demanuele, B E Cade, S Mariani, R Cox, G Panagiotaropoulou, R Saxena, J Q Pan, J W Smoller, S Redline, R Stickgold
Sleep spindles are characteristic electroencephalogram (EEG) signatures of stage 2 non-rapid eye movement sleep. Implicated in sleep regulation and cognitive functioning, spindles may represent heritable biomarkers of neuropsychiatric disease. Here we characterize spindles in 11,630 individuals aged 4 to 97 years, as a prelude to future genetic studies. Spindle properties are highly reliable but exhibit distinct developmental trajectories. Across the night, we observe complex patterns of age- and frequency-dependent dynamics, including signatures of circadian modulation...
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28649624/spaceflight-induced-neuroplasticity-in-humans-as-measured-by-mri-what-do-we-know-so-far
#2
Angelique Van Ombergen, Steven Laureys, Stefan Sunaert, Elena Tomilovskaya, Paul M Parizel, Floris L Wuyts
Space travel poses an enormous challenge on the human body; microgravity, ionizing radiation, absence of circadian rhythm, confinement and isolation are just some of the features associated with it. Obviously, all of the latter can have an impact on human physiology and even induce detrimental changes. Some organ systems have been studied thoroughly under space conditions, however, not much is known on the functional and morphological effects of spaceflight on the human central nervous system. Previous studies have already shown that central nervous system changes occur during and after spaceflight in the form of neurovestibular problems, alterations in cognitive function and sensory perception, cephalic fluid shifts and psychological disturbances...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28645892/meis1-effects-on-motor-phenotypes-and-the-sensorimotor-system-in-mice
#3
Aaro V Salminen, Lillian Garrett, Barbara Schormair, Jan Rozman, Florian Giesert, Kristina M Niedermeier, Lore Becker, Birgit Rathkolb, Ildikó Rácz, Martin Klingenspor, Thomas Klopstock, Eckhard Wolf, Andreas Zimmer, Valérie Gailus-Durner, Miguel Torres, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Sabine M Hölter, Juliane Winkelmann
MEIS1 is a developmental transcription factor linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder leading to severe sleep reduction and with significant impact on the quality-of-life of patients. In genome-wide association studies, MEIS1 has consistently been the gene with the highest effect size and functional studies suggest a disease-relevant downregulation. Therefore, haploinsufficiency of Meis1 could be the most potential system for modeling RLS in animals...
June 23, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28637029/blue-enriched-morning-light-as-a-countermeasure-to-light-at-the-wrong-time-effects-on-cognition-sleepiness-sleep-and-circadian-phase
#4
Mirjam Münch, Claudia Nowozin, Johannes Regente, Frederik Bes, Jan De Zeeuw, Sven Hädel, Amely Wahnschaffe, Dieter Kunz
Light during the day and darkness at night are crucial factors for proper entrainment of the human circadian system to the solar 24-h day. However, modern life and work styles have led to much more time spent indoors, often with lower daytime and higher evening/nighttime light intensity from electrical lighting than outdoors. Whether this has long-term consequences for human health is being currently investigated. We tested if bright blue-enriched morning light over several days could counteract the detrimental effects of inadequate daytime and evening lighting...
June 22, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28636610/chronotypes-in-the-us-influence-of-age-and-sex
#5
Dorothee Fischer, David A Lombardi, Helen Marucci-Wellman, Till Roenneberg
An individual's chronotype reflects how the circadian system embeds itself into the 24-h day with rhythms in physiology, cognition and behavior occurring accordingly earlier or later. In view of an increasing number of people working at unusual times and linked health and safety risks, the wide range in human chronotypes may provide opportunities to allow people to work (and sleep) at times that are in synch with their circadian physiology. We aimed at estimating the distribution of chronotypes in the US population by age and sex...
2017: PloS One
https://www.readbyqxmd.com/read/28634329/long-days-enhance-recognition-memory-and-increase-insulin-like-growth-factor-2-in-the-hippocampus
#6
Adriano Dellapolla, Ian Kloehn, Harshida Pancholi, Ben Callif, David Wertz, Kayla E Rohr, Matthew M Hurley, Kimberly M Baker, Samer Hattar, Marieke R Gilmartin, Jennifer A Evans
Light improves cognitive function in humans; however, the neurobiological mechanisms underlying positive effects of light remain unclear. One obstacle is that most rodent models have employed lighting conditions that cause cognitive deficits rather than improvements. Here we have developed a mouse model where light improves cognitive function, which provides insight into mechanisms underlying positive effects of light. To increase light exposure without eliminating daily rhythms, we exposed mice to either a standard photoperiod or a long day photoperiod...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625430/sensorimotor-and-executive-function-slowing-in-anesthesiology-residents-after-overnight-shifts
#7
George W Williams, Bairavi Shankar, Eliana M Klier, Alice Z Chuang, Salma El Marjiya-Villarreal, Omonele O Nwokolo, Aanchal Sharma, Anne B Sereno
STUDY OBJECTIVE: Medical residents working overnight call shifts experience sleep deprivation and circadian clock disruption. This leads to deficits in sensorimotor function and increases in workplace accidents. Using quick tablet-based tasks, we investigate whether measureable executive function differences exist following a single overnight call versus routine shift, and whether factors like stress, rest and caffeine affect these measures. DESIGN: A prospective, observational, longitudinal, comparison study was conducted...
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28611667/dammarane-sapogenins-ameliorates-neurocognitive-functional-impairment-induced-by-simulated-long-duration-spaceflight
#8
Xiaorui Wu, Dong Li, Junlian Liu, Lihong Diao, Shukuan Ling, Yuheng Li, Jianyi Gao, Quanchun Fan, Weijia Sun, Qi Li, Dingsheng Zhao, Guohui Zhong, Dengchao Cao, Min Liu, Jiaping Wang, Shuang Zhao, Yu Liu, Guie Bai, Hongzhi Shi, Zi Xu, Jing Wang, Chunmei Xue, Xiaoyan Jin, Xinxin Yuan, Hongxing Li, Caizhi Liu, Huiyuan Sun, Jianwei Li, Yongzhi Li, Yingxian Li
Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but the underlying mechanisms and countermeasures need to be explored. In this study, we found that learning and memory abilities were significantly reduced in rats under a simulated long-duration spaceflight environment (SLSE), which includes microgravity, isolation confinement, noises, and altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products of ginsenosides, can enhance cognition function by regulating brain neurotransmitter levels and inhibiting SLSE-induced neuronal injury...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28596466/-clocks-behavior-and-cognition
#9
Akinori Futamura, Azusa Shiromaru, Takeshi Kuroda, Motoyasu Honma, Ryuta Kinno, Kenjiro Ono, Mitsuru Kawamura
The nerve center responsible for controlling our circadian rhythm is located in a cluster of cells known as the suprachiasmatic nucleus in the hypothalamus. Various physiological functions such as sleep, arousal, blood pressure, body temperature, and hormone secretion are regulated in a 24-hour rhythm by this circuit. Somatic cells of other organs have a peripheral clock gene and by synchronizing the rhythm of the central and peripheral clocks, it is possible to live a healthy life. Due to aging and degenerative disease, circadian rhythm gradually collapses...
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28592477/sleep-in-the-intensive-care-unit-in-a-model-of-family-centered-care
#10
Robert L Owens, Truong-Giang Huynh, Giora Netzer
The desire for families to be physically present to support their loved ones in the intensive care unit, and guidelines in favor of this open visitation approach, require that clinicians consider both patient and family sleep. This article reviews the causes of poor sleep for patients and their family members in the intensive care unit as well as the expected changes in cognition and emotion that can result from sleep deprivation. Measures are proposed to improve the intensive care unit environment to promote family sleep...
2017: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/28585737/a-new-measure-of-hallucinatory-states-and-a-discussion-of-rem-sleep-dreaming-as-a-virtual-laboratory-for-the-rehearsal-of-embodied-cognition
#11
Clemens Speth, Jana Speth
Hallucinatory states are experienced not only in connection with drugs and psychopathologies but occur naturally and spontaneously across the human circadian cycle: Our nightly dreams bring multimodal experiences in the absence of adequate external stimuli. The current study proposes a new, tighter measure of these hallucinatory states: Sleep onset, REM sleep, and non-REM sleep are shown to differ with regard to (a) motor imagery indicating interactions with a rich imaginative world, and (b) cognitive agency that could enable sleepers to recognize their hallucinatory state...
June 6, 2017: Cognitive Science
https://www.readbyqxmd.com/read/28581353/four-night-shifts-have-a-degree-of-performance-adaptation
#12
Yu-San Chang, Yu-Hsuan Wu, Hsiang-Lan Chen, Chung-Yao Hsu
OBJECTIVE: In this case control study, we investigated the process of adaptation to night shift (NS) work and recovery back to a day schedule among nurses working a fast-rotation three-shift schedule. BACKGROUND: There is limited knowledge of how specific patterns of a fast-rotation shift affect nurses' performance. METHOD: The cognitive performance of off-duty nurses (OD; n = 21), those working the first night of an NS (1NS; n = 21) and the last night of two ( n = 21), three ( n = 20), and four (4NS; n = 21) successive NSs were compared...
June 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28579842/short-and-long-term-health-consequences-of-sleep-disruption
#13
REVIEW
Goran Medic, Micheline Wille, Michiel Eh Hemels
Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short- and long-term health consequences...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28567500/treatment-of-sleep-dysfunction-in-parkinson-s-disease
#14
REVIEW
Amy W Amara, Lana M Chahine, Aleksandar Videnovic
Impaired sleep and alertness affect the majority of Parkinson's disease (PD) patients, negatively impacting safety and quality of life. The etiology of impaired sleep-wake cycle in PD is multifactorial and encompasses medication side effects, nocturnal PD motor symptoms, and presence of co-existent sleep and neuropsychiatric disorders. The primary neurodegenerative process of PD involves brain regions that regulate the sleep-wake cycle, such as brainstem and hypothalamic nuclei. Sleep disorders in PD include insomnia, REM sleep behavior disorder (RBD), sleep disordered breathing (SDB), restless legs syndrome (RLS), and circadian disruption...
July 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28550253/is-sleep-disruption-a-risk-factor-for-alzheimer-s-disease
#15
Arthur Cassa Macedo, Sara Balouch, Naji Tabet
Sleep disturbances are routinely encountered in Alzheimer's disease (AD) and affect about 25-40% of patients in the mild-to-moderate stages of the disease. In many, sleep pathology may represent a symptom of the underlying neurodegeneration. However, a history of sleep disruption occurring years prior to onset of cognitive symptoms could represent a potential risk factor for AD. The aim of the present narrative review was to evaluate current evidence linking sleep disturbances with AD development and to understand the mechanisms that may contribute to this...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28545364/bright-light-delights-effects-of-daily-light-exposure-on-emotions-rest-activity-cycles-sleep-and-melatonin-secretion-in-severely-demented-patients
#16
Mirjam Münch, Michael Schmieder, Katharina Bieler, Rolf Goldbach, Timo Fuhrmann, Naomi Zumstein, Petra Vonmoos, Jean-Louis Scartezzini, Anna Wirz-Justice, Christian Cajochen
We tested whether the effects of a dynamic lighting system are superior to conventional lighting on emotions, agitation behaviour, quality of life, melatonin secretion and circadian rest-activity cycles in severely demented patients. As a comparison, an age matched control patient group was exposed to conventional lighting. For none of the output measures, significant differences between the two lighting conditions were found during the 8 study weeks in fall/winter. Thus, we divided the patient cohort (n = 89) into two groups, solely based on the median of their daily individual light exposure...
May 22, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28527163/pharmacotherapy-of-insomnia-and-current-updates
#17
REVIEW
Arup Kumar Misra, Pramod Kumar Sharma
Insomnia is highly prevalent and is associated with a range of psychological, psychiatric, and medical conditions. Insomnia affects health by influencing cognitive, emotional and social functioning. Circadian and sleep homeostatic processes play an important role in insomnia development and its maintenance. Several efficacious treatments, both pharmacologic and non-pharmacologic, exist for the management of insomnia. Among non-pharmacologic treatments including stimulus control therapy, sleep restriction, relaxation, sleep hygiene and cognitive therapy have been shown to be efficacious...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28515793/does-the-diurnal-cycle-of-cortisol-explain-the-relationship-between-physical-performance-and-cognitive-function-in-older-adults
#18
B Dijckmans, J Tortosa-Martínez, N Caus, G González-Caballero, B Martínez-Pelegrin, C Manchado-Lopez, J M Cortell-Tormo, I Chulvi-Medrano, A Clow
BACKGROUND: Regular physical activity is a promising strategy to treat and prevent cognitive decline. The mechanisms that mediate these benefits are not fully clear but physical activity is thought to attenuate the harmful effects of chronic psychological stress and hypercortisolism on cognition. However, the circadian pattern of cortisol secretion is complex and it is not known which aspects are most closely associated with increased cognitive function and better physical performance...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28502554/the-9-to-5-rodent-time-for-change-scientific-and-welfare-implications-of-circadian-and-light-effects-on-laboratory-mice-and-rats
#19
Penny Hawkins, Huw D R Golledge
Rodents, particularly rats and mice, are the most commonly used laboratory animals and are extensively used in neuroscience research, including as translational models for human disorders. It is common practice to carry out scientific procedures on rats and mice during the daytime, which is the inactive period for these nocturnal species. However, there is increasing evidence for circadian and light-induced effects on rodent physiology and behaviour which may affect the validity of results obtained from mice and rats in neuroscience studies...
May 11, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28502410/performance-awareness-predicting-cognitive-performance-during-simulated-shiftwork-using-chronobiological-measures
#20
Drew M Morris, June J Pilcher, Joseph B Mulvihill, Melissa A Vander Wood
Physiological tracers of circadian rhythms and a performance awareness index were examined as predictors of cognitive performance during two sleep deprivation conditions common to occupational shiftwork. Study 1: Thirty-three sleep-deprived participants completed a simulated nightshift. Study 2: Thirty-two partially sleep-deprived participants completed a simulated dayshift. A standardized logic test was used to measure cognitive performance. Body temperature and heart rate were measured as chronobiological indices of endogenous circadian rhythms...
September 2017: Applied Ergonomics
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