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https://www.readbyqxmd.com/read/28920453/sensitive-and-comprehensive-analysis-of-o-glycosylation-in-biotherapeutics-a-case-study-of-novel-erythropoiesis-stimulating-protein
#1
Unyong Kim, Myung Jin Oh, Youngsuk Seo, Yinae Jeon, Joon-Ho Eom, Hyun Joo An
AIM: Glycosylation of recombinant human erythropoietins (rhEPOs) is significantly associated with drug's quality and potency. Thus, comprehensive characterization of glycosylation is vital to assess the biotherapeutic quality and establish the equivalency of biosimilar rhEPOs. However, current glycan analysis mainly focuses on the N-glycans due to the absence of analytical tools to liberate O-glycans with high sensitivity. We developed selective and sensitive method to profile native O-glycans on rhEPOs...
September 18, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28919388/altered-brain-functional-connectivity-induced-by-physical-exercise-may-improve-neuropsychological-functions-in-patients-with-benign-epilepsy
#2
Gyan Raj Koirala, Dongpyo Lee, Soyong Eom, Nam-Young Kim, Heung Dong Kim
OBJECTIVE: The objective of this study was to elucidate alteration in functional connectivity (FC) in patients with benign epilepsy with centrotemporal spikes (BECTS) as induced by physical exercise therapy and their correlation to the neuropsychological (NP) functions. METHODS: We analyzed 115 artifact- and spike-free 2-second epochs extracted from resting state EEG recordings before and after 5weeks of physical exercise in eight patients with BECTS. The exact Low Resolution Electromagnetic Tomography (eLORETA) was used for source reconstruction...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28916710/apc-sets-the-wnt-tone-necessary-for-cerebral-cortical-progenitor-development
#3
Naoki Nakagawa, Jingjun Li, Keiko Yabuno-Nakagawa, Tae-Yeon Eom, Martis Cowles, Tavien Mapp, Robin Taylor, E S Anton
Adenomatous polyposis coli (APC) regulates the activity of β-catenin, an integral component of Wnt signaling. However, the selective role of the APC-β-catenin pathway in cerebral cortical development is unknown. Here we genetically dissected the relative contributions of APC-regulated β-catenin signaling in cortical progenitor development, a necessary early step in cerebral cortical formation. Radial progenitor-specific inactivation of the APC-β-catenin pathway indicates that the maintenance of appropriate β-catenin-mediated Wnt tone is necessary for the orderly differentiation of cortical progenitors and the resultant formation of the cerebral cortex...
September 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28913762/the-role-of-computed-tomography-ct-in-predicting-diplopia-in-orbital-blowout-fractures-bofs
#4
Michaela Cellina, Chiara Floridi, Marta Panzeri, Oliva Giancarlo
PURPOSE: The management of orbital blowout fractures (BOFs) is controversial: the evaluation of diplopia is the most important criterion for planning whether to undertake surgery. Our aim was to determine CT findings that may suggest the presence of diplopia when patients with BOFs cannot be adequately examined to plan an orbital repair. METHOD AND MATERIALS: We retrospectively evaluated CT of all patients presented to our Emergency Department for blunt craniofacial trauma (N = 3334) from January 2014 to March 2016, selecting patients with CT-demonstrated BOFs...
September 14, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28913289/communicating-hydrocephalus-onset-following-a-traumatic-tension-pneumocephalus
#5
Jin-Sung Lee, Sora Ahn, Ki Seong Eom
The entrapment of intracranial air from the check valve system results in a tension pneumocephalus. It should be distinguished from simple pneumocephalus because they are intracranial space-occupying masses that can threaten life. Communicating hydrocephalus is a serious and frequent complication of post-traumatic head injury. Head injury is one of the most common causes in etiopathogenesis of communicating hydrocephalus. Here, we describe a case of a 65-year-old man who developed communicating hydrocephalus after a post-traumatic tension pneumocephalus...
December 2016: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912455/a-crispr-screen-identifies-genes-controlling-etv2-threshold-expression-in-murine-hemangiogenic-fate-commitment
#6
Haiyong Zhao, Kyunghee Choi
The ETS transcription factor Etv2 is necessary and sufficient for the generation of hematopoietic and endothelial cells. However, upstream regulators of Etv2 in hemangiogenesis, generation of hematopoietic and endothelial cells, have not been clearly addressed. Here we track the developmental route of hemangiogenic progenitors from mouse embryonic stem cells, perform genome-wide CRISPR screening, and transcriptome analysis of en route cell populations by utilizing Brachyury, Etv2, or Scl reporter embryonic stem cell lines to further understand the mechanisms that control hemangiogenesis...
September 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28910862/effects-of-newly-synthesized-recombinant-human-amyloid-%C3%AE-complexes-and-poly-amyloid-%C3%AE-fibers-on-cell-apoptosis-and-cognitive-decline
#7
Soojin Park, Jae-Won Huh, Taekil Eom, Naeun Na, Youngjeon Lee, Ju-Sung Kim, Sun-Uk Kim, Insop Shim, Sang-Rae Lee, Ekyune Kim
The main pathological hallmark of Alzheimer's disease is the deposition of amyloid-β peptide (Aβ) in the brain. Aβ has been widely used to mimic several aspects of Alzheimer's disease. However, several characteristics of amyloid-induced Alzheimer's disease pathology are not well established, especially in mice. The present study aimed to develop a new Alzheimer's disease model by investigating how amyloid beta can be effectively aggregated using prokaryotes and eukaryotes. To express the Aβ42 complex in HEK293 cells, we cloned the Aβ42 region repeatedly and incorporated the resulting construct into a eukaryotic expression vector...
September 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28904216/anterior-segment-optical-coherence-tomography-of-previously-operated-extraocular-muscles
#8
Matthew S Pihlblad, James D Reynolds
BACKGROUND AND PURPOSE: To assess the possibility of determining the insertion distance from the limbus of previously operated extraocular rectus muscles (EOM) with the Heidelberg Spectralis anterior segment optical coherence tomography (AS-OCT). PATIENT AND METHOD: Subjects with a history of previous strabismus surgery underwent AS-OCT of the EOM before planned additional strabismus surgery. The EOM insertion distances from the limbus were measured pre-operatively on the AS-OCT and compared to the caliper distance measured during the strabismus surgery...
January 2017: American Orthoptic Journal
https://www.readbyqxmd.com/read/28886539/exposure-to-lead-and-mercury-through-breastfeeding-during-the-first-month-of-life-a-check-cohort-study
#9
Yelim Park, Aram Lee, Kyungho Choi, Hai-Joong Kim, Jeong Jae Lee, Gyuyeon Choi, Sungjoo Kim, Su Young Kim, Geum Joon Cho, Eunsook Suh, Sung Koo Kim, So-Hee Eun, Soyong Eom, Seunghyo Kim, Gun-Ha Kim, Hyo-Bang Moon, Sungkyoon Kim, Sooran Choi, Young Don Kim, Jinho Kim, Jeongim Park
Mercury and lead are naturally occurring toxicants and are responsible for various health issues including neurobehavioral and developmental disorders. Because of crucial synchronized developmental processes occurring at the early stage of life, infancy and childhood are considered as among the most susceptible windows to the exposure to these metals. Breastmilk is often the only source of nutrition during the first months of life. As breastmilk can be contaminated with these metals, breastfeeding may serve as a significant route of heavy metal exposure among infants...
September 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28884981/ultrastructural-changes-in-skeletal-muscle-of-infants-with-mitochondrial-respiratory-chain-complex-i-defects
#10
Ji Young Mun, Min Kyo Jung, Se Hoon Kim, Soyong Eom, Sung Sik Han, Young Mock Lee
BACKGROUND AND PURPOSE: The pathogenesis of mitochondrial disease (MD) involves the disruption of cellular energy metabolism, which results from defects in the mitochondrial respiratory chain complex (MRC). We investigated whether infants with MRC I defects showed ultrastructural changes in skeletal muscle. METHODS: Twelve infants were enrolled in this study. They were initially evaluated for unexplained neurodegenerative symptoms, myopathies, or other progressive multiorgan involvement, and underwent muscle biopsies when MD was suspected...
September 4, 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28880706/identification-of-cellular-responses-to-low-dose-radiation-by-the-profiling-of-phosphorylated-proteins-in-human-b-lymphoblast-im-9-cells
#11
Hyeon Soo Eom, Hyung Sun Park, Ga Eun You, Ji Young Kim, Seon Young Nam
PURPOSE: The aim of this study was to explore the potential for radiation-specific signaling of various LDIR-induced effects in human B-lymphoblast IM-9 cells. MATERIALS AND METHODS: Human lymphoblast IM-9 cells were exposed to ionization radiation at 0.1 and 2 Gy using a (137)Cs γ-irradiator at a dose rate of 0.8 Gy/min. Cell viability and DNA fragmentation was determined using MTT assay and TUNEL assay at 24 hr after irradiation. Profiling of protein phosphorylation by radiation was identified using a phospho-antibody array at 4 hr after irradiation and Dataset of the profiling was analyzed by IPA...
September 7, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28877574/sparganosis-of-the-unilateral-breast-a-case-report
#12
Hyung Suk Kim, Man Sik Shin, Chang Jong Kim, Sun Hyung You, Yong Hwa Eom, Tae Kyung Yoo, Ahwon Lee, Byung Joo Song, Byung Joo Chae
Sparganosis is a parasitic infection caused by the sparganum, the plercercoid of the genus Spirometra. The preoperative diagnosis of breast sparganosis is difficult in most cases because it is a rare parasitic infection less than 2% of all cases. We report a 62-year-old woman case of breast sparganosis that were confirmed by surgical removal of worms from the right breast. The radiologic images of the patient also revealed characteristic features of breast sparganosis. The patient described the migrating palpable breast mass, which strongly suggested the possibility of breast sparganosis...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28876460/viral-etiology-of-sporadic-cases-of-parotitis-among-children-in-korea-during-2013-2014
#13
Hae Ji Kang, Sun Hee Kim, Jae Keun Chung, Soon Won Lee, Seung Bong Choi, Hye Eun Eom, Ok Park, Kisoon Kim, Sung Soon Kim
Recent years have seen a high incidence of mumps, which is generally diagnosed based on clinical features, especially parotitis, without laboratory confirmation in Korea. To better understand the epidemiology of mumps in Korean children, we investigated sporadic suspected mumps cases with parotitis. In total, 237 buccal swabs or throat swabs collected from children with parotitis who had been clinically diagnosed with mumps were tested using real-time PCR for the detection of six viruses (Epstein-Barr virus, Human herpesvirus 6, Mumps virus, Human parainfluenza virus-1, -2, -3, Human adenovirus, Human bocavirus)...
September 6, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28875552/diphenylpyridine-amine-substituted-porphyrins-as-hole-transporting-materials-for-perovskite-solar-cells
#14
Un-Hak Lee, Randi Azmi, Septy Sinaga, Sunbin Hwang, Seung Hun Eom, Tae-Wook Kim, Sung Cheol Yoon, Sung-Yeon Jang, In Hwan Jung
The susceptibility of porphyrin derivatives to light-harvesting and charge-transport operations have enabled these materials to be employed in solar cell applications. The potential of porphyrin derivatives as hole-transporting materials (HTMs) for perovskite solar cells (PSCs) has recently been demonstrated, but research on the relationships between the porphyrin structure and device performance remains insufficient. In this work, a series of novel porphyrin derivatives, PZn-TPA-O, PZn-TPA, PZn-DPPA-O and PZn-DPPA, are developed and employed as HTMs for low-temperature processed PSCs...
September 5, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28875118/multimodality-management-of-cavernous-sinus-hemangiomas-an-institutional-experience
#15
Dwarakanath Srinivas, Pragyan Sarma, Dhaval Shukla, Dhananjay Bhat, Paritosh Pandey, Sampath Somanna, Ananthakrishna Chandramouli
Objective  Cavernous sinus hemangiomas (CSHs) are benign lesions accounting for less than 2% of the cavernous sinus tumors. They provide a formidable surgical challenge because of their vascularity and their being surrounded by critical neurovascular structures. In this study, one of the largest in available literature, we analyze our experience in the management of these unusual tumors and review the available literature. Materials  This is a retrospective analysis of patients who were managed surgically (both microsurgical and Gamma knife radiosurgery [GKRS]) for CSH at our Institution from 2007 to 2015...
October 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28868922/second-look-arthroscopic-evaluation-and-clinical-outcome-after-supramalleolar-osteotomy-for-medial-compartment-ankle-osteoarthritis
#16
Hong-Geun Jung, Dong-Oh Lee, Sang-Hun Lee, Joon-Sang Eom
BACKGROUND: The aim of this study was to evaluate the clinical and radiologic outcomes of medial compartment ankle osteoarthritis after supramalleolar osteotomy (SMO) without the bone marrow stimulation procedure and confirm cartilage recovery by second-look arthroscopy. METHODS: Twenty-two ankles that were followed for more than 1 year after SMO were retrospectively reviewed. Visual analog scale pain scores and American Orthopaedic Foot & Ankle Society ankle-hindfoot scores were used for functional evaluations...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28865348/prediction-of-muscle-activation-for-an-eye-movement-with-finite-element-modeling
#17
Abbas Karami, Mohammad Eghtesad, Seyyed Arash Haghpanah
In this paper, a 3D finite element (FE) modeling is employed in order to predict extraocular muscles' activation and investigate force coordination in various motions of the eye orbit. A continuum constitutive hyperelastic model is employed for material description in dynamic modeling of the extraocular muscles (EOMs). Two significant features of this model are accurate mass modeling with FE method and stimulating EOMs for motion through muscle activation parameter. In order to validate the eye model, a forward dynamics simulation of the eye motion is carried out by variation of the muscle activation...
August 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28860954/distinct-clinical-outcomes-between-paramedullary-and-extramedullary-lesions-in-newly-diagnosed-multiple-myeloma
#18
Khishigjargal Batsukh, Sung-Eun Lee, Gi June Min, Sung Soo Park, Young-Woo Jeon, Jae-Ho Yoon, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Hee-Je Kim, Seok Lee, Seok-Goo Cho, Dong-Wook Kim, Jong Wook Lee, Woo-Sung Min, Chang-Ki Min
This retrospective study aimed to compare the clinical features of paramedullary lesions (PLs) and extramedullary lesions (ELs) of plasmacytomas at diagnosis, using positron emission tomography integrated with computed tomography, using glucose labeled with the positron-emitting radionuclide (18)F ((18)F-FDG-PET/CT) in newly diagnosed multiple myeloma (NDMM), and to address their prognostic impact. Sixty-four patients with NDMM presenting ELs (n=22) and/or PLs (n=42) were included. Patients with ELs at initial presentation had unfavorable laboratory parameters of calcium and lactate dehydrogenase, a higher percentage of bone marrow plasma cells, and showed a trend toward advanced international staging system (ISS), compared to patients with PLs...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28859395/association-of-high-dose-postoperative-opioids-with-recurrence-risk-in-esophageal-squamous-cell-carcinoma-reinterpreting-eras-protocols-for-long-term-oncologic-surgery-outcomes
#19
T K Oh, J H Jeon, J M Lee, M S Kim, J H Kim, H Lim, S-E Kim, W Eom
Esophageal squamous cell carcinoma (ESCC) is associated with a poor prognosis and high postoperative recurrence rate. Although postoperative opioid use has been associated with cancer recurrence, its relevance in ESCC has not been determined. Therefore, this study investigated whether high-dose postoperative opioid use was associated with recurrence risk in patients with ESCC. For this retrospective analysis, the medical records of patients who were diagnosed with ESCC and who underwent surgery between January 2006 and December 2010 in the National Cancer Center, Korea were evaluated...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28856705/effect-of-solvation-on-the-ionization-of-guanine-nucleotide-a-hybrid-qm-efp-study
#20
Rahul Chakraborty, Samik Bose, Debashree Ghosh
Ionization of nucleobases is affected by their biological environment, which includes both the effect of adjacent nucleotides as well as the presence of water around it. Guanine and its nucleotide have the lowest ionization potentials among the various DNA bases. Therefore, the threshold of ionization is dependent on that of guanine and its characterization is crucial to the prediction of interaction of light with DNA. We investigate the effect of solvation on the vertical ionization energies (VIEs) of guanine and its nucleotide...
August 30, 2017: Journal of Computational Chemistry
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