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https://www.readbyqxmd.com/read/28815219/conventional-nk-cells-and-ilc1-are-partially-ablated-in-the-livers-of-ncr1-icre-tbx21-fl-fl-mice
#1
Antonia O Cuff, Victoria Male
Mouse liver contains both Eomes-dependent conventional natural killer (cNK) cells and Tbet-dependent liver-resident type I innate lymphoid cells (ILC1). In order to better understand the role of ILC1, we attempted to generate mice that would lack liver ILC1, while retaining cNK, by conditional deletion of Tbet in NKp46+ cells. Here we report that the Ncr1 (iCre)Tbx21 (fl/fl) mouse has a roughly equivalent reduction in both the cNK and ILC1 compartments of the liver, limiting its utility for investigating the relative contributions of these two cell types in disease models...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28815050/a-case-of-azoospermia-in-a-non-destructive-testing%C3%A2-worker-exposed-to-radiation
#2
Jaechan Park, Sanggil Lee, Chulyong Park, Huisu Eom
BACKGROUND: Interest in radiation-related health problems has been growing with the increase in the number of workers in radiation-related jobs. Although an occupational level of radiation exposure would not likely cause azoospermia, several studies have reported the relation between radiation exposure and azoospermia after accidental or therapeutic radiation exposure. We describe a case of azoospermia in a non-destructive testing (NDT) worker exposed to radiation and discuss the problems of the related monitoring system...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28814615/single-cell-gene-expression-of-the-bovine-blastocyst
#3
Veronica M Negrón-Pérez, Yanping Zhang, Peter J Hansen
The first two differentiation events in the blastocyst result in three cell types - epiblast, trophectoderm (TE), and hypoblast. The purpose here was to identify molecular markers for each cell type in the bovine and evaluate differences in gene expression among individual cells of each lineage. The cDNA from 67 individual cells from dissociated blastocysts was used to determine transcript abundance for 96 genes implicated as cell lineage markers in other species or potentially involved in developmental processes...
August 16, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28811967/il-18-receptor-marks-functional-cd8-t-cells-in-non-small-cell-lung-cancer
#4
Eleonora Timperi, Chiara Focaccetti, Daniela Gallerano, Mariangela Panetta, Sheila Spada, Enzo Gallo, Paolo Visca, Federico Venuta, Daniele Diso, Arsela Prelaj, Flavia Longo, Francesco Facciolo, Paola Nisticò, Vincenzo Barnaba
IL-18 is an inflammasome-related cytokine, member of the IL-1 family, produced by a wide range of cells in response to signals by several pathogen- or damage-associated molecular patterns. It can be highly represented in tumor patients, but its relevance in human cancer development is not clear. In this study, we provide evidence that IL-18 is principally expressed in tumor cells and, in concert with other conventional Th1 cell-driven cytokines, has a pivotal role in establishing a pro-inflammatory milieu in the tumor microenvironment of human non-small cell lung cancer (NSCLC)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28810754/on-the-adiabatic-representation-of-meyer-miller-electronic-nuclear-dynamics
#5
Stephen J Cotton, Ruibin Liang, William H Miller
The Meyer-Miller (MM) classical vibronic (electronic + nuclear) Hamiltonian for electronically non-adiabatic dynamics-as used, for example, with the recently developed symmetrical quasiclassical (SQC) windowing model-can be written in either a diabatic or an adiabatic representation of the electronic degrees of freedom, the two being a canonical transformation of each other, thus giving the same dynamics. Although most recent applications of this SQC/MM approach have been carried out in the diabatic representation-because most of the benchmark model problems that have exact quantum results available for comparison are typically defined in a diabatic representation-it will typically be much more convenient to work in the adiabatic representation, e...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28808389/simultaneous-determination-of-four-compounds-campesterol-emodin8-o-%C3%AE-d-glucopyranoside-quercetin-and-isoquercitrin-in-reynoutria-sachalinensis-by-high-performance-liquid-chromatography-diode-array-detector
#6
Min Rye Eom, Jin Bae Weon, Youn Sik Jung, Ga Hee Ryu, Woo Seung Yang, Choong Je Ma
BACKGROUND: Reynoutria sachalinensis is a well-known and used herbal medicine to treatment of arthralgia, jaundice, amenorrhea, coughs, carbuncles, and sores. OBJECTIVE: We have developed high-performance liquid chromatography analysis method for simultaneous determination of isolated four compounds, campesterol, emodin8-O-β-D-glucopyranoside, quercetin, and isoquercitrin from R. sachalinensis is. MATERIALS AND METHODS: The four compounds were separated on Shiseido C18 column (S-5 μm, 4...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28808206/the-effect-of-sunblock-against-oxidative-stress-in-farmers-a-pilot-study
#7
Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Ji Yeoun Lee, Heon Kim
Farmers are frequently exposed to ultraviolet (UV) radiation which causes various diseases by inducing oxidative stress. This study aimed to assess the effects of sunblock on oxidative stress in the body. Eighty-seven farmers were divided into two groups: those who wore sunblock for five days and those who did not. The total antioxidant capacity (TAC) in urine, which is an antioxidant indicator, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in urine, an oxidative stress indicator, were measured. The urinary TAC of sunblock users was significantly higher than that of non-users, but urinary 8-OHdG levels were not significantly different...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28806520/tailoring-the-doping-mechanisms-at-oxide-interfaces-in-nanoscale
#8
Weitao Dai, Ming Yang, Hyungwoo Lee, Jung-Woo Lee, Chang-Beom Eom, Cheng Cen
Here, we demonstrate the nanoscale manipulations of two types of charge transfer to the LaAlO3/SrTiO3 interfaces: one from surface adsorbates and another from oxygen vacancies inside LaAlO3 films. This method can be used to produce multiple insulating and metallic interface states with distinct carrier properties that are highly stable in air. By reconfiguring the patterning and comparing interface structures formed from different doping sources, effects of extrinsic and intrinsic material characters on the transport properties can be distinguished...
August 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28803022/short-communication-antioxidative-and-antibacterial-activities-on-staphylococcus-aureus-and-escherichia-coli-o157-h4-in-milk-with-added-ginseng-marc-extract-fermented-by-lactobacillus-plantarum-kccm-11613p
#9
S J Eom, J E Hwang, J Jung, H-S Jee, K-T Kim, H-D Paik
Ginseng marc, a by-product of the extraction of fresh ginseng, is known to have bioactive compounds, but is frequently discarded as agriculture waste. The objectives of our study were to assess the antioxidative activity of fermented ginseng marc extract using Lactobacillus plantarum KCCM 11613P and to evaluate antibacterial activity of fermented milk with added ginseng marc extract during fermentation. After 24 h of fermentation of ginseng marc extract, the viable cell number was increased to 7.7 ± 0.1 log cfu/mL, and the pH and total titratable acidity were 4...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28790368/signs-of-innate-immune-activation-and-premature-immunosenescence-in-psoriasis-patients
#10
Liisi Šahmatova, Elena Sügis, Marina Šunina, Helen Hermann, Ele Prans, Maire Pihlap, Kristi Abram, Ana Rebane, Hedi Peterson, Pärt Peterson, Külli Kingo, Kai Kisand
Psoriasis is a chronic inflammatory disease that affects skin and is associated with systemic inflammation and many serious comorbidities ranging from metabolic syndrome to cancer. Important discoveries about psoriasis pathogenesis have enabled the development of effective biological treatments blocking the T helper 17 pathway. However, it has not been settled whether psoriasis is a T cell-mediated autoimmune disease or an autoinflammatory disorder that is driven by exaggerated innate immune signalling. Our comparative gene expression and hierarchical cluster analysis reveal important gene circuits involving innate receptors...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783000/multiclass-mycotoxin-analysis-in-edible-oils-using-a-simple-solvent-extraction-method-and-liquid-chromatography-with-tandem-mass-spectrometry
#11
Taeyong Eom, Hyun-Deok Cho, Junghyun Kim, Mihee Park, Jinyoung An, Moosung Kim, Sheen-Hee Kim, Sang Beom Han
A simple and rapid method for the simultaneous determination of eleven mycotoxins-aflatoxins B1, B2, G1, and G2; fumonisins B1, B2, and B3; ochratoxin A; zearalenone; deoxynivalenol; and T-2 toxin-in edible oils was established using liquid chromatography tandem mass spectrometry (LC-MS/MS). In this study, QuEChERS, QuEChERS with dispersive liquid-liquid microextraction, and solvent extraction were examined for sample preparation. Among these methods, solvent extraction with a mixture of formic acid/acetonitrile (5/95, v/v) successfully extracted all target mycotoxins...
August 7, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28772644/design-optimization-and-structural-performance-evaluation-of-plate-girder-bridge-constructed-using-a-turn-over-process
#12
Gi-Ha Eom, Sung Jae Kim, Tae-Hee Lee, Jang-Ho Jay Kim
A recent trend in bridge construction has been the optimization of the cost-to-performance ratio. The most effective way to optimize the cost-to-performance ratio is to maximize the efficiency of the superstructure. Currently, many bridge engineers and designers favor two- or three- girder plate superstructures, due to their cost advantages. However, research on the performance enhancements of the I-type girder in two- or three- girder plate bridges is lacking. One of the most important performance improvement technologies for the I-type girder is the "preflex" method...
March 13, 2017: Materials
https://www.readbyqxmd.com/read/28766978/comparison-of-variability-in-breast-density-assessment-by-bi-rads-category-according-to-the-level-of-experience
#13
Hye-Joung Eom, Joo Hee Cha, Ji-Won Kang, Woo Jung Choi, Han Jun Kim, EunChae Go
Background Only few studies have assessed variability in the results obtained by the readers with different experience levels in comparison with automated volumetric breast density measurements. Purpose To examine the variations in breast density assessment according to BI-RADS categories among readers with different experience levels and to compare it with the results of automated quantitative measurements. Material and Methods Density assignment was done for 1000 screening mammograms by six readers with three different experience levels (breast-imaging experts, general radiologists, and students)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28765163/epigenome-profiling-and-editing-of-neocortical-progenitor-cells-during-development
#14
Mareike Albert, Nereo Kalebic, Marta Florio, Naharajan Lakshmanaperumal, Christiane Haffner, Holger Brandl, Ian Henry, Wieland B Huttner
The generation of neocortical neurons from neural progenitor cells (NPCs) is primarily controlled by transcription factors binding to DNA in the context of chromatin. To understand the complex layer of regulation that orchestrates different NPC types from the same DNA sequence, epigenome maps with cell type resolution are required. Here, we present genomewide histone methylation maps for distinct neural cell populations in the developing mouse neocortex. Using different chromatin features, we identify potential novel regulators of cortical NPCs...
August 1, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28764500/note-a-four-pass-acousto-optic-modulator-system-for-laser-cooling-of-sodium-atoms
#15
Bo Lu, Dajun Wang
We present a four-pass acousto-optic modulator (AOM) system for providing the repumping light for laser cooling of sodium atoms. With only one 400 MHz AOM, we achieve a tunable laser frequency shift around 1.6 GHz with total efficiency up to 30%. This setup provides an alternative over conventional methods to generate a sodium repumping light using more expensive high frequency AOMs or electro-optical modulators (EOMs) in the GHz domain. This compact and reliable setup can be easily adapted to other frequencies and may find applications in laser spectroscopy, laser cooling and trapping, and coherent manipulation of atomic quantum states...
July 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28759001/tumor-immunoevasion-by-the-conversion-of-effector-nk-cells-into-type-1-innate-lymphoid-cells
#16
Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel, Michele W L Teng, Gabrielle T Belz, Christian R Engwerda, Nicholas D Huntington, Kyohei Nakamura, Michael Hölzel, Mark J Smyth
Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a(-)CD49b(+)Eomes(+)) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a(+)CD49b(+)Eomes(+)) populations and ILC1 (CD49a(+)CD49b(-)Eomes(int)) populations in the tumor microenvironment...
July 31, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28758191/il-27-signaling-induces-stem-cell-antigen-1-expression-in-t-lymphocytes-in-vivo
#17
Zhihao Liu, Lisha Wu, Jing Zhu, Xiaotong Zhu, Jianmin Zhu, Jin-Qing Liu, Jianchao Zhang, Jonathan P Davis, Sanjay Varikuti, Abhay R Satoskar, Jie Zhou, Ming-Song Li, Xue-Feng Bai
Stem cell antigen-1 (Sca-1/Ly6A/E) is a cell surface glycoprotein that is often used as a biomarker for stem cells and cell stemness. However, it is not clear what factors can directly induce the expression of Sca-1/Ly6A/E in T lymphocytes in vivo, and if induction of Sca-1 is associated with T cell stemness. In this study, we show that IL-27, a member of the IL-12 family of cytokines, directly induces Sca-1 expression in T cells in vivo. We found that mice-deficient for IL-27 (either P28 or EBI3) or its signaling (IL-27Rα) had profound reduction of Sca-1 expression in naïve (CD62L(+) CD44(-) ), memory (CD62L(+) CD44(+) ) and effector (CD62L(-) CD44(+) ) T cells...
July 31, 2017: Immunology
https://www.readbyqxmd.com/read/28754997/dual-function-au-y2o3-eu-3-smart-film-for-enhanced-power-conversion-efficiency-and-long-term-stability-of-perovskite-solar-cells
#18
Chang Woo Kim, Tae Young Eom, In Seok Yang, Byung Su Kim, Wan In Lee, Yong Soo Kang, Young Soo Kang
In the present study, a dual-functional smart film combining the effects of wavelength conversion and amplification of the converted wave by the localized surface plasmon resonance has been investigated for a perovskite solar cell. This dual-functional film, composed of Au nanoparticles coated on the surface of Y2O3:Eu(3+) phosphor (Au@Y2O3:Eu(3+)) nanoparticle monolayer, enhances the solar energy conversion efficiency to electrical energy and long-term stability of photovoltaic cells. Coupling between the Y2O3:Eu(3+) phosphor monolayer and ultraviolet solar light induces the latter to be converted into visible light with a quantum yield above 80%...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751785/ctla4-cd28-chimera-gene-modification-of-t-cells-enhances-the-therapeutic-efficacy-of-donor-lymphocyte-infusion-for-hematological-malignancy
#19
Hyung Bae Park, Ji Eun Lee, Yu Mi Oh, Sang Jin Lee, Hyeon-Seok Eom, Kyungho Choi
Donor lymphocyte infusion (DLI) followed by hematopoietic stem cell transplantation has served as an effective prevention/treatment modality against the relapse of some hematologic tumors, such as chronic myeloid leukemia (CML). However, the therapeutic efficacies of DLI for other types of leukemia, including acute lymphocytic leukemia (ALL), have been limited thus far. Therefore, we examined whether increasing the reactivity of donor T cells by gene modification could enhance the therapeutic efficacy of DLI in a murine model of ALL...
July 28, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28749677/nature-inspired-construction-of-two-dimensionally-self-assembled-peptide-on-pristine-graphene
#20
Young Hyun No, Nam Hyeong Kim, Bramaramba Gnapareddy, Bumjoon Choi, Yong-Tae Kim, Sreekantha Reddy Dugasani, One-Sun Lee, Kook-Han Kim, Young-Seon Ko, Seungwoo Lee, Sang Woo Lee, Sung Ha Park, Kilho Eom, Yong Ho Kim
Peptide assemblies have received significant attention because of their important role in biology and applications in bionanotechnology. Despite recent efforts to elucidate the principles of peptide self-assembly for developing novel functional devices, peptide self-assembly on two-dimensional nanomaterials has remained challenging. Here, we report nature-inspired two-dimensional peptide self-assembly on pristine graphene via optimization of peptide-peptide and peptide-graphene interactions. Two-dimensional peptide self-assembly was designed based on statistical analyses of >10(4) protein structures existing in nature and atomistic simulation-based structure predictions...
July 31, 2017: Journal of Physical Chemistry Letters
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