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Cow milk tolerance

M Ebrahimi, M Gharagozlou, A Khalili, K Magaji Hamid, G Azizi, M Movahedi
No abstract text is available yet for this article.
October 2016: Journal of Investigational Allergology & Clinical Immunology
Salvatore Chirumbolo
The recent paper by Nucera et al., showed that the basophil activation test (BAT) in flow cytometry is able to monitor an acquired tolerance induced by a desensitization treatment in food allergy. The paper by Nucera et al. reported two standpoints in the CD63 response to food allergy and OAT and their large difference in CD63 response before and after suggests for the optimal performance of a CD123/HLADR/CD63 BAT in oral food allergy immunotherapy.
October 2016: United European Gastroenterology Journal
J B Garner, M L Douglas, S R O Williams, W J Wales, L C Marett, T T T Nguyen, C M Reich, B J Hayes
Dairy products are a key source of valuable proteins and fats for many millions of people worldwide. Dairy cattle are highly susceptible to heat-stress induced decline in milk production, and as the frequency and duration of heat-stress events increases, the long term security of nutrition from dairy products is threatened. Identification of dairy cattle more tolerant of heat stress conditions would be an important progression towards breeding better adapted dairy herds to future climates. Breeding for heat tolerance could be accelerated with genomic selection, using genome wide DNA markers that predict tolerance to heat stress...
September 29, 2016: Scientific Reports
J E Rico, A T Mathews, J Lovett, N J Haughey, J W McFadden
Reduced insulin action is a key adaptation that facilitates glucose partitioning to the mammary gland for milk synthesis and enhances adipose tissue lipolysis during early lactation. The progressive recovery of insulin sensitivity as cows advance toward late lactation is accompanied by reductions in circulating nonesterified fatty acids (NEFA) and milk yield. Because palmitic acid can promote insulin resistance in monogastrics through sphingolipid ceramide-dependent mechanisms, palmitic acid (C16:0) feeding may enhance milk production by restoring homeorhetic responses...
September 13, 2016: Journal of Dairy Science
A T Mathews, J E Rico, N T Sprenkle, A L Lock, J W McFadden
Feeding saturated fatty acids may enhance milk yield in part by decreasing insulin sensitivity and shifting glucose utilization toward the mammary gland. Our objective was to evaluate the effects of palmitic acid (C16:0) on milk production and insulin sensitivity in cows. Twenty multiparous mid-lactation Holstein cows were enrolled in a study consisting of a 5-d covariate, 49-d treatment, and 14-d posttreatment period. All cows received a common sorghum silage-based diet and were randomly assigned to a diet containing no supplemental fat (control; n = 10; 138 ± 45 d in milk) or C16:0 at 4% of ration DM (PALM; 98% C16:0; n = 10; 136 ± 44 d in milk)...
September 13, 2016: Journal of Dairy Science
L H Oliveira, A B Nascimento, P L J Monteiro, M M Guardieiro, M C Wiltbank, R Sartori
The objective of this study was to test the hypothesis that high-producing dairy cows become increasingly resistant to insulin throughout lactation and that, consequently, oocyte quality is compromised. We used Holstein cows at 50 (51.5 ± 3.7; n = 30), 100 (102.3 ± 9.4; n = 30), and 150 (154.5 ± 18.9; n = 30) days in milk (DIM). We measured circulating insulin and glucose and performed a glucose tolerance test (GTT) after 5 h of fasting. To evaluate oocyte quality, we performed ovum pickup on the day before the GTT (581 oocytes)...
August 24, 2016: Journal of Dairy Science
Jean Christoph Caubet, Ramon Bencharitiwong, Andrew Ross, Hugh A Sampson, M Cecilia Berin, Anna Nowak-Węgrzyn
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy manifesting within 1 to 4 hours of food ingestion with repetitive emesis and lethargy. OBJECTIVE: We sought to characterize immune responses to casein in children with FPIES caused by cow's milk (CM). METHODS: Total IgE and IgM, CM-specific IgG, and casein-specific IgE, IgG, IgG4, and IgM levels, as well as immunoglobulin free light chains, were measured in both patients with active and those with resolved CM-FPIES...
July 15, 2016: Journal of Allergy and Clinical Immunology
M L Santana, A B Bignardi, R J Pereira, G Stefani, L El Faro
Tropical and sub-tropical climates are characterized by high temperature and humidity, during at least part of the year. Consequently, heat stress is common in Holstein cattle and productive and reproductive losses are frequent. Our objectives were as follows: (1) to quantify losses in production and quality of milk due to heat stress; (2) to estimate genetic correlations within and between milk yield (MY) and milk quality traits; and (3) to evaluate the trends of genetic components of tolerance to heat stress in multiple lactations of Brazilian Holstein cows...
August 17, 2016: Animal: An International Journal of Animal Bioscience
Lorella Paparo, Rita Nocerino, Linda Cosenza, Rosita Aitoro, Valeria D'Argenio, Valentina Del Monaco, Carmen Di Scala, Antonio Amoroso, Margherita Di Costanzo, Francesco Salvatore, Roberto Berni Canani
BACKGROUND: DNA methylation of the Th1 and Th2 cytokine genes is altered during cow's milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. RESULTS: Forty children (aged 3-18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4)...
2016: Clinical Epigenetics
J A R MacPherson, H Berends, L N Leal, J P Cant, J Martín-Tereso, M A Steele
The objective of this study was to investigate how preweaning plane of milk replacer intake and age can affect insulin and glucose kinetics as well as abomasal emptying rate in dairy calves fed twice a day. A total of 12 female Holstein Friesian calves were blocked by cow parity, paired by colostrum origin, and were randomly assigned to a high plane of milk replacer intake (8 L/d, 1.2kg of milk replacer/d; n=6) or a low plane of nutrition (4 L/d, 0.6kg of milk replacer/d; n=6). All calves received 4 L of colostrum over 2 meals (1 and 6h after birth) and were then directly transferred to their assigned feeding plans until they were stepped-down from milk by 50% during wk 7 and weaned on wk 8...
October 2016: Journal of Dairy Science
P J Gorden, J A Ydstie, M D Kleinhenz, L W Wulf, R Gehring, C J Lee, C Wang, J F Coetzee
Metritis is a frequent problem in postpartum dairy cows. Intrauterine therapy with the antimicrobial oxytetracycline (OTC) is often used, although this therapy has not been shown to be superior to systemic therapy. The objectives of this study were to (1) determine the plasma and milk concentrations of OTC following intrauterine infusion in postpartum dairy cows with varying degrees of metritis severity; (2) determine the depletion time of OTC in an attempt to provide veterinarians withdrawal guidelines, should they use this therapy; and (3) correlate metritis severity scores with OTC concentrations in plasma and milk...
October 2016: Journal of Dairy Science
L Chini, V Pacciani, S Corrente, E Monteferrario, M L Romiti, V Moschese, F Angelini
No abstract text is available yet for this article.
2016: Journal of Investigational Allergology & Clinical Immunology
Karthiyaini Damodharan, Sasikumar Arunachalam Palaniyandi, Seung Hwan Yang, Joo-Won Suh
We characterized the probiotic properties of Lactobacillus helveticus strains KII13 and KHI1 isolated from fermented cow milk by in vitro and in vivo studies. The strains exhibited tolerance to simulated oro-gastrointestinal (OGT) condition, adherence to Caco-2 cells, and antimicrobial activity. Both the L. helveticus strains produced bioactive tripeptides isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) during fermentation of milk. KII13 showed higher in vitro cholesterol-lowering activity (47%) compared to KHI1 (28%) and L...
July 19, 2016: Journal of Microbiology and Biotechnology
Christophe Dupont, Elena Bradatan, Pascale Soulaines, Rita Nocerino, Roberto Berni-Canani
BACKGROUND: In case of cow's milk allergy (CMA), pediatric guidelines recommend for children the use of extensively hydrolyzed formulas (eHFs) as elimination diet. According to the American Academy of Pediatrics, the hypoallergenicity of each specific eHF should be tested in subjects with CMA. METHODS: A prospective, multicenter trial was performed to assess the tolerance/hypoallergenicity of a thickened casein-based eHF (eHCF, Allernova AR®, United Pharmaceuticals, France) in infants aged <12 months with CMA proven by a double-blind placebo-controlled food challenge...
2016: BMC Pediatrics
M F Martín-Muñoz, F Pineda, G García Parrado, D Guillén, D Rivero, T Belver, S Quirce
BACKGORUND: Food allergy is a rare disorder among breastfeeding babies. OBJECTIVE: Our aim was to identify responsible allergens in human milk. METHODS: We studied babies developing allergic symptoms at the time they were breastfeeding. Skin prick tests (SPT) were performed with breast milk and food allergens. Specific IgE was assessed and IgE Immunoblotting experiments with breast milk were carried out to identify food allergens. Clinical evolution was evaluated after a maternal free diet...
July 2016: European Annals of Allergy and Clinical Immunology
Julian F Guest, Diana Weidlich, Maciej Kaczmarski, Elzbieta Jarocka-Cyrta, Natalia Kobelska-Dubiel, Agnieszka Krauze, Iwona Sakowska-Maliszewska, Anna Zawadzka-Krajewska
OBJECTIVE: To estimate the cost-effectiveness of using an extensively hydrolyzed casein formula (eHCF) containing the probiotic Lactobacillus rhamnosus GG (eHCF + LGG; Nutramigen LGG) as an initial treatment for cow's milk allergy compared with eHCF alone and amino acid formulas (AAF) in Poland from the perspective of the Polish National Health Fund (Narodowy Fundusz Zdrowia [NFZ]) and parents. METHODS: Decision modeling was used to estimate the probability of cow's milk allergic infants developing tolerance to cow's milk by 18 months...
2016: ClinicoEconomics and Outcomes Research: CEOR
Laura Pieper, Rudolf Staufenbiel, Jana Christ, Lothar Panicke, Uwe Müller, Gudrun A Brockmann
Selection for improved health and welfare in farm animals is of increasing interest worldwide. Peripartum energy balance is a key factor for pathogenesis of diseases in dairy cows. The intravenous glucose tolerance test (ivGTT) can be used to study the metabolic response to a glucose stimulus. The aim of this study was to estimate heritability of ivGTT traits in German Holstein bulls. A total of 541 Holstein bulls aged 7 to 17 mo from 2 breeding stations were subjected to the ivGTT. Serum glucose concentrations were measured at 0, 7, 14, 21, 28, 35, 42, 49, 56, and 63 min relative to glucose infusion...
September 2016: Journal of Dairy Science
Silvia Salvatore, Yvan Vandenplas
Hydrolyzed proteins are used worldwide in the therapeutic management of infants with allergic manifestations and have long been proposed as a dietetic measure to prevent allergy in at risk infants. The degree and method of hydrolysis, protein source and non-nitrogen components characterize different hydrolyzed formulas (HFs) and may determine clinical efficacy, tolerance and nutritional effects. Cow's milk (CM)-based HFs are classified as extensively (eHF) or partially HF (pHF) based on the percentage of small peptides...
2016: Nestlé Nutrition Institute Workshop Series
Valérie Trendelenburg, Katharina Blümchen
During recent years increasing research has been conducted on casual treatment options for food allergy, with focus on oral immunotherapy (OIT) for hen's egg, cow's milk and peanut allergy. Several studies could show that OIT leads to desensitization or an increase of threshold. However, severe adverse events during this treatment are not uncommon. Whether OIT leads to a sustained, 'robust' development of tolerance in patients has not yet been thoroughly investigated. Besides OIT, some studies on sublingual (SLIT) and epicutaneous immunotherapy (EPIT) were performed, aiming to improve the safety profile...
July 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Mignon T van den Elzen, Harmieke van Os-Medendorp, Heike Röckmann-Helmbach, Els van Hoffen, Ans F M Lebens, Helma van Doorn, Rob J B Klemans, Carla A F M Bruijnzeel-Koomen, C Erik Hack, Leonard Kaufman, Anurag Relan, André C Knulst
BACKGROUND: Recombinant human C1 inhibitor (rhC1INH) for on-demand treatment of hereditary angioedema is purified from milk of transgenic rabbits. It contains low amounts (<0.002%) of host-related impurities, which could trigger hypersensitivity reactions in patients with rabbit allergy (RA) and/or cow's milk allergy (CMA). OBJECTIVE: This study is an assessment of allergenicity and safety of rhC1INH in patients with RA and/or CMA. METHODS: Patients with CMA and/or RA underwent skin prick test (SPT), intracutaneous test (ICT), and, when results for both were negative, subcutaneous (SC) challenge with up to 2100U (14 mL) rhC1INH...
August 2016: Journal of Allergy and Clinical Immunology
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