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JOURNAL ARTICLE
Kamal El Abd, Valérie Pékus, Marie Fagnard, Caroline Hoeters, Charles Monfort, Julie Sterck, Isabelle Pirotte
Cow's milk protein allergy (CMPA) is the leading cause of food allergy in young children. Despite the spontaneous acquisition of tolerance in the majority of cases at school age, the impact of CMPA on the quality of life of the child and his/her family is clearly more deleterious than in other food allergies. The milk scale, a form of oral immunotherapy, accelerates the acquisition of tolerance such as to curb this negative impact, through a process of gradually reintroducing milk into the diet of the allergic patient...
April 2023: Revue Médicale de Liège
#22
REVIEW
Caoimhe Cronin, Yukta Ramesh, Carlo De Pieri, Roberto Velasco, Juan Trujillo
IgE-mediated cow's milk protein allergy (CMPA) is one of the most prevalent food allergies in early childhood. Though the cornerstone of management involves the strict avoidance of milk products while awaiting natural tolerance, research increasingly shows that the rates of resolution are slowing down. Therefore, there is a need to explore alternative pathways to promote tolerance to cow's milk in pediatric populations. This review aims to combine and appraise the scientific literature regarding the three CMPA management methods: avoidance, the milk ladder, and oral immunotherapy (OIT) and their outcomes in terms of efficacy, safety, and immunological effects...
March 14, 2023: Nutrients
#23
JOURNAL ARTICLE
Xing Zhang, HuaQiang Zhang, YingKui Gao, ZhongHua Hao, JingJing Liu, GuangWei Zhou, Fang Liu, Xiao Li, Chao Tong, XueBing Wang
Dairy cow mastitis is the most common disease encountered in dairy farming. Lipopolysaccharides (LPS), among the major virulence-related factors produced by Escherichia coli, stimulate mammary gland inflammation and cause its damage, thereby affecting milk yield and quality. Forsythoside A (FTA) is among the main active components of forsythia. Recent pharmacological studies have demonstrated that FTA possesses anti-inflammatory, antiviral, antioxidant, and other biological activities. This study investigated the effects of the FTA-activated AMP-activated protein kinase (AMPK) signaling pathway on LPS-induced autophagy, apoptosis, and inflammatory damage in bovine mammary epithelial (MAC-T) cells...
March 23, 2023: International Immunopharmacology
#24
REVIEW
Vanessza Emmert, Dominika Lendvai-Emmert, Kata Eklics, Viktória Prémusz, Gergely Péter Tóth
Cow's milk protein allergy is one of the most common pediatric food allergies. It poses a significant socioeconomic burden in industrialized countries and has a profound effect on the quality of life of affected individuals and their families. Diverse immunologic pathways can lead to the clinical symptoms of cow's milk protein allergy; some of the pathomechanisms are known in detail, but others need further elucidation. A comprehensive understanding of the development of food allergies and the features of oral tolerance could have the potential to unlock more precise diagnostic tools and novel therapeutic approaches for patients with cow's milk protein allergy...
March 6, 2023: International Journal of Molecular Sciences
#25
REVIEW
Guillaume Pouessel, Guillaume Lezmi
Oral immunotherapy (OIT) is now recognized as an alternative active treatment to strict food avoidance in certain patients with IgE-mediated food allergy. Studies have confirmed the efficacy of OIT to desensitize children with allergy to cow's milk, eggs, and peanuts. The benefits, risks, and constraints of OIT are becoming increasingly well understood. However, there is no consensual criteria to select patients to whom OIT could be proposed, and many issues remain to address including the definitions of desensitization and long-term efficacy, the assessment of patient's experience in real life, the optimization of buildup and maintenance protocols, and the utility of multiple food OIT...
February 2023: World Allergy Organization Journal
#26
JOURNAL ARTICLE
K Yamamoto-Hanada, M Sato, K Toyokuni, M Irahara, E Hiraide-Kotaki, N Harima-Mizusawa, H Morita, K Matsumoto, Y Ohya
Safer and more effective cow milk (CM)-oral immunotherapy that does not induce allergic reactions has not yet been standardised. We sought to explore the efficacy and feasibility of a combination of heat-killed Lactiplantibacillus plantarum YIT 0132 (LP0132) and oral immunotherapy for treating IgE-mediated cow milk allergy (CMA). We conducted a 24-week, double-blind, randomised (1:1), two-arm, parallel-group, placebo-controlled, phase 2 trial of LP0132 intervention for treating IgE-mediated CMA in children aged 1-18 years (n=60) from January 29, 2018 to July 12, 2019 in Tokyo, Japan...
February 23, 2023: Beneficial Microbes
#27
JOURNAL ARTICLE
Keiko Kameda, Etsuhisa Takahashi, Takashi Kimoto, Ryoko Morita, Satoko Sakai, Mizuho Nagao, Takao Fujisawa, Hiroshi Kido
Food allergy is one of the major existing health problems, but no effective treatment is available. In the current work, a murine model that closely mimics pathogenesis of human food allergy and its quantifiable diagnostic parameter design, even for mild hypersensitivity reactions, were established. BALB/c mice were epicutaneously sensitized with 1 mg chicken egg ovomucoid (OVM) or cow's milk casein, free of adjuvants, five times a week for two consecutive weeks. Eleven days later, allergen-specific IgG1 and IgE in serum were measured by ELISA...
February 2, 2023: Nutrients
#28
JOURNAL ARTICLE
Angélica Torres-Arroyo, Juan Martínez-Aguilar, Adriana Castillo-Villanueva, Flora Zárate-Mondragón, Roberto Cervantes-Bustamante, Genaro Patiño-López, Oscar Medina-Contreras, Sara Elva Espinosa-Padilla, Silvia Valencia-Rojas, Lina Romero-Guzmán, Jesús Oria-Hernández, Horacio Reyes-Vivas
Immunological mechanisms of non-IgE-mediated cow's milk protein allergy (CMPA) are not well understood. Such a circumstance requires attention with the aim of discovering new biomarkers that could lead to better diagnostic assays for early treatment. Here, we sought both to investigate the mechanism that underlies non-IgE-mediated CMPA and to identify cow's milk immunoreactive proteins in a Mexican pediatric patient group (n = 34). Hence, we determined the IgE and IgG1 - 4 subclass antibody levels against cow's milk proteins (CMP) by ELISA...
December 29, 2022: Journal of Proteomics
#29
JOURNAL ARTICLE
Maria Angela Tosca, Roberta Olcese, Guido Marinelli, Irene Schiavetti, Giorgio Ciprandi
Cow milk allergy (CMA) is a prevalent disease in childhood. Natural history is usually favorable as CMA can disappear by school age in many subjects. Diagnosis corresponds to treatment, as an elimination diet is a solution. However, cow's milk (CM) is real food, hardly replaceable. Thus, CM reintroduction represents a demanding challenge in clinical practice. The induction of CM tolerance could be achievable using oral immunotherapy (OIT), such as the administration of increasing milk quantities until reaching tolerance...
November 30, 2022: Children
#30
REVIEW
Lu Qin, Lan-Fang Tang, Lei Cheng, Hui-Ying Wang
IgG4 is a subclass of IgG antibody with a unique molecular feature of (Fragment antigen- binding) Fab-arm exchange, allowing bi specific antigen binding in a mono -valent manner. With low binding affinity to C1q and Fcγreceptors, IgG4 is incapable of forming immune complexes and activating the complement pathway, exhibiting a non-inflammatory feature. IgG4 is produced similarly to IgE and is considered a modified reaction to IgE class-switching response under certain conditions. It could also counteract IgE-activated inflammation...
2022: Frontiers in Immunology
#31
JOURNAL ARTICLE
Yitzhak Katz, Michal Melchior, Arnon Elizur, Liat Nachshon, Benjamin Carl Remington, Moshe Leshno
BACKGROUND: The safe consumption of foods depends on their allergen content in relation to patient Lowest Observed Adverse Effect Level (LOAEL) and No Observed Adverse Effect Level (NOAEL), and other factors. In the case of milk, data on LOAEL and NOAEL is limited and conflicting. OBJECTIVE: To determine the threshold dose distribution and the lowest individual ED for milk in a large group of milk allergic patients METHODS: Individuals with confirmed cow's milk allergy who underwent either a diagnostic or pre-oral immunotherapy (OIT) open milk oral food challenge in The Institute of Allergy, Immunology, and Pediatric Pulmonology at Shamir Medical Center, between 2010 and 2015 were included...
November 12, 2022: Journal of Allergy and Clinical Immunology in Practice
#32
JOURNAL ARTICLE
Miguel Gonzalez-Visiedo, Michael D Kulis, David M Markusic
Loss of oral tolerance (OT) to food antigens results in food allergies. One component of achieving OT is the symbiotic microorganisms living in the gut (microbiota). The composition of the microbiota can drive either pro-tolerogenic or pro-inflammatory responses against dietary antigens though interactions with the local immune cells within the gut. Products from bacterial fermentation, such as butyrate, are one of the main communication molecules involved in this interaction, however, this is released by a subset of bacterial species...
October 22, 2022: Cellular Immunology
#33
JOURNAL ARTICLE
Cristina Benítez Provedo, María Angeles Martínez Ibeas, Rebeca Losada Del Pozo, Ana María Montes Arjona, Miriam Blanco Rodríguez, Genoveva Del Río Camacho
Introduction: ketogenic diet is a treatment with proven efficacy in drug-refractory childhood epilepsy. Cow's milk protein allergy may be a limitation for treating infants with ketogenic diet, as they need a product that contains cow's milk protein (Ketocal®). Case report: we report the case of an infant with a drug-refractory epileptic encephalopathy and IgE-mediated cow's milk protein allergy, who started a classic ketogenic diet. Oral desensitization was achieved with Ketocal 3:1®, allowing its use in the diet and achieving a clinical improvement with seizure control...
December 20, 2022: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
#34
JOURNAL ARTICLE
Cristina Morales-Cabeza, Sonsoles Infante, Paula Cabrera-Freitag, Victoria Fuentes-Aparicio, José Manuel Zubeldia, Alberto Álvarez-Perea
OBJECTIVES: Oral immunotherapy (OIT) is an effective treatment for children with persistent food allergy, and has concerns about its safety, including eosinophilic esophagitis (EoE). The aim of this study was to evaluate the prevalence of EoE in a large cohort of children who underwent OIT in our center, and to determine if there were any clinical, endoscopic, or histologic differences depending on the food employed for the OIT. METHODS: A retrospective study was performed over a 15-year period (2005-2020)...
January 1, 2023: Journal of Pediatric Gastroenterology and Nutrition
#35
JOURNAL ARTICLE
Antonio Bognanni, Derek K Chu, Ramon T Firmino, Stefania Arasi, Siw Waffenschmidt, Arnav Agarwal, Piotr Dziechciarz, Andrea Horvath, Rime Jebai, Hanako Mihara, Yetiani Roldan, Maria Said, Raanan Shamir, Martin Bozzola, Sami Bahna, Alessandro Fiocchi, Susan Waserman, Holger J Schünemann, Jan L Brożek
Background: Allergy to cow's milk is the most common food allergy in infants and it is usually outgrown by 5 years of age. In some individuals it persists beyond early childhood. Oral immunotherapy (OIT, oral desensitization, specific oral tolerance induction) has been proposed as a promising therapeutic strategy for persistent IgE-mediated cow's milk allergy. We previously published the systematic review of OIT for cow's milk allergy (CMA) in 2010 as part of the World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines...
September 2022: World Allergy Organization Journal
#36
REVIEW
Lujing Tang, Yu Yu, Xiangyuan Pu, Jie Chen
BACKGOUND: Cow's milk allergy (CMA) is the most common allergy in infants that decreases the quality of life of patients and their families. Standard treatment for CMA is the strict avoidance of milk; new treatment strategies such as oral immunotherapy (OIT) have been sought for patients with CMA. We aimed to assess the clinical efficacy and safety of OIT in the treatment of children with immunoglobulin E-mediated CMA (IMCMA). METHODS: We searched all randomized controlled trials in which OIT is used to treat children with IMCMA from five international electronic databases...
October 2022: Immunity, Inflammation and Disease
#37
REVIEW
Antonella Muraro, Debra de Silva, Susanne Halken, Margitta Worm, Ekaterina Khaleva, Stefania Arasi, Audrey Dunn-Galvin, Bright I Nwaru, Nicolette W De Jong, Pablo Rodríguez Del Río, Paul J Turner, Pete Smith, Philippe Begin, Elizabeth Angier, Hasan Arshad, Barbara Ballmer-Weber, Kirsten Beyer, Carsten Bindslev-Jensen, Antonella Cianferoni, Céline Demoulin, Antoine Deschildre, Motohiro Ebisawa, Maria Montserrat Fernandez-Rivas, Alessandro Fiocchi, Bertine Flokstra-de Blok, Jennifer Gerdts, Josefine Gradman, Kate Grimshaw, Carla Jones, Susanne Lau, Richard Loh, Montserrat Alvaro Lozano, Mika Makela, Mary Jane Marchisotto, Rosan Meyer, Clare Mills, Caroline Nilsson, Anna Nowak-Wegrzyn, Ulugbek Nurmatov, Giovanni Pajno, Marcia Podestà, Lars K Poulsen, Hugh A Sampson, Angel Sanchez, Sabine Schnadt, Hania Szajewska, Ronald Van Ree, Carina Venter, Berber Vlieg-Boerstra, Amena Warner, Gary Wong, Robert Wood, Torsten Zuberbier, Graham Roberts
Food allergy affects approximately 2-4% of children and adults. This guideline provides recommendations for managing food allergy from the Global Allergy and Asthma European Network (GA2 LEN). A multidisciplinary international Task Force developed the guideline using the Appraisal of Guidelines for Research and Evaluation (AGREE) II framework and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We reviewed the latest available evidence as of April 2021 (161 studies) and created recommendations by balancing benefits, harms, feasibility, and patient and clinician experiences...
September 2022: World Allergy Organization Journal
#38
Izabela Knyziak-Mędrzycka, Monika Szychta, Emilia Majsiak, Andrzej M Fal, Zbigniew Doniec, Bożena Cukrowska
The case of a 9-month-old boy with an initial diagnosis of atopic dermatitis and confirmed allergy to hen's egg, cow's milk allergens with episodes of anaphylaxis who developed birch allergy whilst under observation with asthma symptoms was presented. The precision allergy molecular diagnosis (PAMD @) allowed for individualisation of dietary recommendations and observing the early progression of food sensitisation to the main birch molecule. The presented identification of major allergic molecules with PAMD@ in the preclinical phase of asthma contributes to the discussion related to early specific immunotherapy to suppress molecular spread and allergic march...
2022: Journal of Asthma and Allergy
#39
JOURNAL ARTICLE
Jianhua Zeng, Kai Lin, Xiaoqian Zhang, Junzhe Zou, Lanwei Zhang, Pimin Gong, Jinlong Zhao, Chunhua Han, Yuhai Liu, Huaxi Yi, Tongjie Liu
αs1-Casein (αs1-CN) is a major cow milk allergen, while the tertiary structure of αs1-CN and conformational epitopes of αs1-CN have not been clarified. Here, a reasonable three-dimensional structure of αs1-CN was established using ab initio methods, and hot-spot residues and epitopes were investigated by combining molecular dynamics simulation, peptides synthesis, and ELISA. Obtained results demonstrated that the binding mechanism between αs1-CN and IgG was located on three main regions: a helical structure zone (E77-Q97), the flexible loop zone (Y154-T174), and a flexible C-terminal (N190-L198), mainly connecting via hydrogen bond and ionic bonds...
August 22, 2022: Food Chemistry
#40
JOURNAL ARTICLE
Tiina Kaisa Kauppila, Victoria Hinkkanen, Terhi Savinko, Piia Karisola, Anna Kaarina Kukkonen, Marita Paassilta, Anna S Pelkonen, Mika J Mäkelä
BACKGROUND: Milk oral immunotherapy (OIT) may increase the amount of milk protein that can be ingested without triggering an allergic reaction. It is important to understand why some patients benefit from the treatment while others do not. OBJECTIVE: The aim was to define the differences in the milk allergen component-specific (casein, α-lactalbumin, ß-lactoglobulin) immunoglobulin (sIg [sIgE, sIgG4, and sIgA]) levels relative to the long-term outcomes of milk OIT...
August 15, 2022: Allergy
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