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Cow milk allergy immunotherapy

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https://www.readbyqxmd.com/read/27931280/safety-profile-of-oral-immunotherapy-with-cows-milk-and-hen-egg-a-10-year-experience-in-controlled-trials
#1
Giovanni B Pajno, Lucia Caminiti, Fernanda Chiera, Giuseppe Crisafulli, Giuseppina Salzano, Stefania Arasi, Giovanni Passalacqua
BACKGROUND: Oral immunotherapy (OIT) for food allergy is gaining interest due to the favorable clinical results reported with cow's milk, hen egg and peanut. The safety of the procedure remains a critical aspect that can limit the introduction of OIT in clinical practice. OBJECTIVE: We described herein, in detail, the occurrence and characteristics of adverse events (AE) with OIT in children who participated in controlled trials at our unit. METHODS: The clinical records of 68 children who received active treatment (40 for cow's milk and 28 for hen egg) were carefully reviewed...
September 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27826960/oral-food-desensitization-in-children-with-ige-mediated-cow-s-milk-allergy-immunological-changes-underlying-desensitization
#2
Laura Perezábad, Marta Reche, Teresa Valbuena, Rosina López-Fandiño, Elena Molina, Iván López-Expósito
PURPOSE: This study aimed to evaluate the safety and efficacy to induce clinical desensitization to cow's milk (CM) of an oral immunotherapy (OIT) protocol in a pediatric population with cow's milk allergy (CMA). In addition, the immune responses against β-casein, of peripheral blood mononuclear cells (PBMCs) from CMA patients, before and after the protocol were evaluated and compared to a nonallergic population. METHODS: A group of 20 children with IgE-mediated CMA and 15 nonallergic children were recruited...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27822230/erratum-to-two-weeks-sustained-unresponsiveness-by-oral-immunotherapy-using-microwave-heated-cow-s-milk-for-children-with-cow-s-milk-allergy
#3
Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi, Kazuanri Kaneko
[This corrects the article DOI: 10.1186/s13223-016-0150-0.].
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27763871/induction-of-tolerance-by-oral-immunotherapy-in-patients-with-cow-s-milk-allergy
#4
M Ebrahimi, M Gharagozlou, A Khalili, K Magaji Hamid, G Azizi, M Movahedi
No abstract text is available yet for this article.
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27733914/basophil-activation-test-in-oral-desensitization-to-cow-s-milk-allergy
#5
Salvatore Chirumbolo
The recent paper by Nucera et al., showed that the basophil activation test (BAT) in flow cytometry is able to monitor an acquired tolerance induced by a desensitization treatment in food allergy. The paper by Nucera et al. reported two standpoints in the CD63 response to food allergy and OAT and their large difference in CD63 response before and after suggests for the optimal performance of a CD123/HLADR/CD63 BAT in oral food allergy immunotherapy.
October 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27570533/two-weeks-sustained-unresponsiveness-by-oral-immunotherapy-using-microwave-heated-cow-s-milk-for-children-with-cow-s-milk-allergy
#6
Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi, Kazuanri Kaneko
BACKGROUND: Several studies have reported that oral immunotherapy (OIT) is effective for children with cow's milk (CM) allergy. These studies reported the efficacy of OIT in terms of desensitization, but did not describe sustained unresponsiveness to CM. The aim of this study was to evaluate the efficacy of the OIT protocol using microwave heated cow's milk (MH-CM) in terms of 2-weeks-sustained unresponsiveness (2-weeks-SU) and safety. METHODS: Forty-eight children were enrolled in this study...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27540712/t-cell-epitope-containing-hypoallergenic-%C3%AE-lactoglobulin-for-oral-immunotherapy-in-milk-allergy
#7
Hiroshi M Ueno, Teruhiko Kato, Hidenori Ohnishi, Norio Kawamoto, Zenichiro Kato, Hideo Kaneko, Naomi Kondo, Taku Nakano
BACKGROUND: Optimally hydrolyzed β-Lactoglobulin (βLg) is a promising milk oral immunotherapy (OIT) candidate with respect to showing reduced B-cell reactivity but retaining the T-cell epitope. To demonstrate that an edible hypoallergenic βLg hydrolysate containing the T-cell epitope is suitable for OIT. We tested how chymotrypsin affected the retention of the T-cell epitope of βLg when preparing βLg hydrolysates using food-grade trypsin. METHODS: We investigated the effect of chymotrypsin activity on the formation of the T-cell epitope-containing peptide of βLg (βLg102-124 ) and prepared an edible βLg hydrolysate containing βLg102-124 using screened food-grade trypsins...
August 19, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27537244/changes-in-biomarkers-during-a-six-month-oral-immunotherapy-intervention-for-cow-s-milk-allergy
#8
Susanna Salmivesi, Marita Paassilta, Heini Huhtala, Riina Nieminen, Eeva Moilanen, Matti Korppi
AIM: Oral immunotherapy (OIT) is a promising but still experimental method to treat children with cow's milk (CM) allergy (CMA). We evaluated changes in allergic, immunological and inflammatory parameters, which happened during the six-month OIT for CMA. METHODS: We treated 28 school-aged children with CMA using OIT with a double-blind placebo-controlled design. After the controlled study finished, the placebo group was treated with the same but open-label OIT protocol...
November 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27324376/-allergen-specific-immunotherapy-for-food-allergies-in-childhood-current-options-and-future-perspectives
#9
Valérie Trendelenburg, Katharina Blümchen
During recent years increasing research has been conducted on casual treatment options for food allergy, with focus on oral immunotherapy (OIT) for hen's egg, cow's milk and peanut allergy. Several studies could show that OIT leads to desensitization or an increase of threshold. However, severe adverse events during this treatment are not uncommon. Whether OIT leads to a sustained, 'robust' development of tolerance in patients has not yet been thoroughly investigated. Besides OIT, some studies on sublingual (SLIT) and epicutaneous immunotherapy (EPIT) were performed, aiming to improve the safety profile...
July 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27286276/markers-of-tolerance-development-to-food-allergens
#10
REVIEW
M Ponce, S C Diesner, Z Szépfalusi, T Eiwegger
IgE-mediated reactions to food allergens are the most common cause of anaphylaxis in childhood. Although allergies to cow's milk, egg, or soy proteins, in contrast to peanut and tree nut allergens, resolve within the first 6 years of life in up to 60% due to natural tolerance development, this process is not well understood. At present, there is no cure or treatment for food allergy that would result in an induction of tolerance to the symptom-eliciting food. Avoidance, providing an emergency plan and education, is the standard of treatment...
October 2016: Allergy
https://www.readbyqxmd.com/read/27207693/-food-allergy-in-childhood
#11
Kirsten Beyer, Bodo Niggemann
IgE-mediated immediate type reactions are the most common form of food allergy in childhood. Primary (often in early childhood) and secondary (often pollen-associated) allergies can be distinguished by their level of severity. Hen's egg, cow's milk and peanut are the most common elicitors of primary food allergy. Tolerance development in hen's egg and cow's milk allergy happens frequently whereas peanut allergy tends toward a lifelong disease. For the diagnostic patient history, detection of sensitization and (in many cases) oral food challenges are necessary...
June 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/26683057/a-single-center-case-control-study-of-low-dose-induction-oral-immunotherapy-with-cow-s-milk
#12
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Yu Okada, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: This study aimed to investigate the efficacy and safety of low-dose-induction oral immunotherapy (OIT) with 3 ml of milk, which is a lower target volume than is conventionally used. METHODS: Children aged ≥5 years with milk allergies [confirmed by oral food challenge (OFC) against 3 ml of milk] were enrolled. The OIT group was admitted to the hospital for 5 days for build-up. Subsequently, at home, the volume was gradually increased by up to a maximum of 3 ml every 5 days...
2015: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/26617227/oral-immunotherapy-for-food-allergy
#13
REVIEW
Allison J Burbank, Puja Sood, Brian P Vickery, Robert A Wood
Food allergy is a potentially life-threatening condition with no approved therapies, apart from avoidance and injectable epinephrine for acute allergic reactions. Oral immunotherapy (OIT) is an experimental treatment in which food-allergic patients consume gradually increasing quantities of the food to increase their threshold for allergic reaction. This therapy carries significant risk of allergic reactions. The ability of OIT to desensitize patients to particular foods is well-documented, although the ability to induce tolerance has not been established...
February 2016: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/26595763/food-allergy-in-childhood-phenotypes-prevention-and-treatment
#14
REVIEW
Silvia Sánchez-García, Francesca Cipriani, Giampaolo Ricci
The prevalence of food allergy in childhood increased in the last decades, especially in Westernized countries where this phenomenon has been indicated as a second wave of the allergic epidemic. In parallel, scientific interest also increased with the effort to explain the reasons of this sudden rise and to identify potential protective and risk factors. A great attention has been focused on early exposures to allergenic foods, as well as on other nutritional factors or supplements that may influence the immune system in a positive direction...
December 2015: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/26593873/improving-the-safety-of-oral-immunotherapy-for-food-allergy
#15
REVIEW
Marta Vazquez-Ortiz, Paul J Turner
Food allergy is a major public health problem in children, impacting upon the affected individual, their families and others charged with their care, for example educational establishments, and the food industry. In contrast to most other paediatric diseases, there is no established cure: current management is based upon dietary avoidance and the provision of rescue medication in the event of accidental reactions, which are common. This strategy has significant limitations and impacts adversely on health-related quality of life...
March 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/26581915/a-randomized-double-blind-placebo-controlled-study-of-omalizumab-combined-with-oral-immunotherapy-for-the-treatment-of-cow-s-milk-allergy
#16
RANDOMIZED CONTROLLED TRIAL
Robert A Wood, Jennifer S Kim, Robert Lindblad, Kari Nadeau, Alice K Henning, Peter Dawson, Marshall Plaut, Hugh A Sampson
BACKGROUND: Although studies of oral immunotherapy (OIT) for food allergy have shown promise, treatment is frequently complicated by adverse reactions and, even when successful, has limited long-term efficacy because benefits usually diminish when treatment is discontinued. OBJECTIVE: We sought to examine whether the addition of omalizumab to milk OIT reduces treatment-related reactions, improves outcomes, or both. METHODS: This was a double-blind, placebo-controlled trial with subjects randomized to omalizumab or placebo...
April 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26503614/children-who-were-treated-with-oral-immunotherapy-for-cows-milk-allergy-showed-long-term-desensitisation-seven-years-later
#17
Marita Paassilta, Susanna Salmivesi, Tiina Mäki, Mika Helminen, Matti Korppi
AIM: This was a follow-up of 28 schoolchildren with cows' milk allergy (CMA) who attended a randomised double-blind placebo-controlled oral immunotherapy (OIT) study. In the original study, 26 (92.9%) completed the six-month escalation phase, and 25 (89.3%) used milk daily at 12 months and 24 (85.7%) at 36 months. This study evaluated the outcome seven years later, with special attention paid to milk consumption and symptoms. METHODS: Outcome data were collected through a postal questionnaire completed three, four and five years after enrolment and by a phone questionnaire after seven years...
February 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26194541/efficacy-of-baked-milk-oral-immunotherapy-in-baked-milk-reactive-allergic-patients
#18
Michael R Goldberg, Liat Nachshon, Michael Y Appel, Arnon Elizur, Michael B Levy, Eli Eisenberg, Hugh A Sampson, Yitzhak Katz
BACKGROUND: Patients with IgE-mediated cow's milk allergy who are nonreactive to baked milk (BM) can be desensitized with BM to promote tolerance to unheated milk (UM). OBJECTIVE: We sought to test whether patients who are BM reactive can progress in BM oral immunotherapy (OIT) and become desensitized to UM as well. METHODS: Fifteen patients (>4 years) who previously failed to complete our milk OIT program were enrolled into the BM OIT protocol...
December 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26194477/half-of-the-children-who-received-oral-immunotherapy-for-a-cows-milk-allergy-consumed-milk-freely-after-2-5-years
#19
Juho E Kivistö, Matti Korppi, Mika Helminen, Tiina Mäki, Marita Paassilta
AIM: Strict milk protein avoidance has been the standard therapy of cows' milk allergy (CMA) in children, but oral immunotherapy (OIT) seems to provide an alternative treatment. The aim of this study was to evaluate the impact of OIT on milk consumption during the first 2.5 years after a start of OIT. METHODS: This open-label, noncontrolled, real-life OIT study was conducted in 74 children with CMA, who were aged 5-15. It included a 6-month induction phase and a 2-year maintenance phase...
November 2015: Acta Paediatrica
https://www.readbyqxmd.com/read/26064142/successful-desensitization-in-a-boy-with-severe-cow-s-milk-allergy-by-a-combination-therapy-using-omalizumab-and-rush-oral-immunotherapy
#20
Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi, Kazunari Kaneko
BACKGROUND: Rush oral immunotherapy (OIT) combined with omalizumab (OMB) has been reported to be an effective and safe treatment for severe milk allergies. However, no report has described long-term follow-up observations after OMB discontinuation. The purpose of this case report was to evaluate the safety and efficacy of rush OIT in combination with OMB during a long period of treatment. CASE PRESENTATION: A 5-year-old boy presented with a past history of two severe episodes of anaphylaxis (at the age of 2 and 3 years) after consuming small amounts of cow's milk (CM)...
2015: Allergy, Asthma, and Clinical Immunology
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