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Naomi Konishi, Takao Iwanaga, Yoshito Ishino, Aya Sugisawa, Shozo Ide, Hiroko Kimura, Takashi Iwata, Hideki Watanabe, Takeshi Yokoe, Eiki Ojima, Hideki Ito, Tetsuya Ikeda, Hitoshi Tonouchi, Chika Shigemori
A 52-year-old woman presented with redness and swelling with a peau d'orange appearance in the whole right breast. Ultrasound revealed elevated subcutaneus fat density and a diffuse hypoechoic area. She was diagnosed with inflammatory breast cancer(T4dN2M0, Stage III B of the HER2 subtype). After 4 courses of EC treatment as primary systemic therapy, the hypoechoic area was still present. Subsequent chemotherapy with pertuzumab, trastuzumab, and docetaxel was effective, as hypoechoic area was not observed on ultrasound...
September 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kirk Barber
No abstract text is available yet for this article.
September 2016: Journal of Cutaneous Medicine and Surgery
Jacob Ninan, Vinay Naik, Gemy Maria George
A 67-year-old woman with a history of lung adenocarcinoma presented with 3 weeks of redness, pain, swelling and skin changes in her right breast. Her vital signs and physical examination were within physiological limits except for the right breast. She had extensive red streaks radiating from the right nipple with peau d'orange appearance of her overlying skin. Her breast was tender on examination and did not have any associated cervical or axillary lymphadenopathy. Her mammography revealed thickening of the skin, increased parenchymal markings and shrinkage the breast...
2016: BMJ Case Reports
L Provencher, J C Hogue, C Desbiens, B Poirier, E Poirier, D Boudreau, M Joyal, C Diorio, N Duchesne, J Chiquette
BACKGROUND: Screening clinical breast examination (cbe) is controversial; the use of cbe is declining not only as a screening tool, but also as a diagnostic tool. In the present study, we aimed to assess the value of cbe in breast cancer detection in a tertiary care centre for breast diseases. METHODS: This retrospective study of all breast cancers diagnosed between July 1999 and December 2010 at our centre categorized cases according to the mean of detection (cbe, mammography, or both)...
August 2016: Current Oncology
Aslı Aksu Çerman, Ezgi Aktaş, Ilknur Kıvanç Kıvanç Altunay, Cuyan Demirkesen
Connective tissue nevi (CTN) are dermal hamartomas characterized by an imbalance in the amount and distribution of the normal components of the extracellular dermal matrix, specifically collagen, elastin, and/or proteoglicans. The term "CTN" was first mentioned by Lewandowsky in 1921 (1), although it was not accepted until the review by Gutmann in 1926 (2). Classification of CTN was established by Uitto et al. (3) in 1980 according to clinical, genetic, and histopathological features. But this classification did not include zosteriform nevi...
June 2016: Acta Dermatovenerologica Croatica: ADC
Aliki Liaska, Petros Petrou, Constantinos D Georgakopoulos, Ramza Diamanti, Dimitris Papaconstantinou, Menelaos G Kanakis, Ilias Georgalas
BACKGROUND: Beta-thalassemia is a severe genetic blood disorder caused by a mutation in the gene encoding for the beta chains of hemoglobin. Individuals with beta-thalassemia major require regular lifelong Red Blood Cell transfusions to survive. Ocular involvement is quite common and may have serious implications. METHODS: Extensive review of observational studies on beta-thalassemia, to determine the prevalence and spectrum of ocular abnormalities, by clinical examination and multimodal imaging, and to investigate risk factors for their development...
2016: BMC Ophthalmology
A Bachir Cherif, A Taleb, A Bouraghda, A Atif, C Labat, A Chibane, M Temmar, A Benetos, M Bouafia
OBJECTIFS: Comparer le profil morpho-hémodynamique de la population noire du sud algérien avec celui de la population blanche des mêmes oasis algériennes. Comparer la morbi-mortalité cardiovasculaire et totale entre les deux populations. MéTHODES: 1 425 patients âgés de 40 ans et plus des 2 sexes et des 2 couleurs de peau, blanche et noire. L'étude consiste à réexaminer, avec un recul de 6 ans, les sujets de l'étude Oasis 1, réalisée à In Salah en 2002, et les sujets de l'étude SAHA 1, réalisée en 2004, dans 6 autres oasis...
December 2015: Annales de Cardiologie et D'angéiologie
A Bachir Cherif, A Taleb, A Bouraghda, A Atif, C Labat, A Chibane, M Temmar, A Benetos, M Bouafia
OBJECTIFS: Étude de l'observance thérapeutique. Étude de l'efficacité des différentes classes thérapeutiques anti-hypertensives dans cette population. Comparer avec la population blanche des mêmes oasis algériennes. MéTHODES: 1 550 sujets, des deux sexes et des deux couleurs de peau, âgés de 40 ans et plus, habitant le Sahara algérien ont été revu après 6 ans de recul. Le contrôle a consisté à remplir un questionnaire orienté sur l'état civil, complété par un examen clinique incluant la morphométrie, la mesure de la PA avec appareil électronique validé (OMRON 705CP)...
December 2015: Annales de Cardiologie et D'angéiologie
X Girerd, F Villeneuve, C H Gury, D Rosenbaum
OBJECTIFS: L'hypertension du sujet noir est réputée comme étant plus difficile à prendre en charge. L'objectif de cette étude est d'évaluer si chez l'hypertendu la couleur de la peau est associée à des difficultés d'obtention du contrôle de la pression artérielle. MéTHODES: En 2015, des patients vus de façon consécutive pour la première fois en consultation dans une unité spécialisée en HTA d'un CHU d'Île-de-France ont été inclus. Chez 108 patients un suivi a été proposé comportant un bilan étiologique et du retentissement...
December 2015: Annales de Cardiologie et D'angéiologie
Lily Koo Lin
BACKGROUND: Surgical videography can provide analytical self-examination for the surgeon, teaching opportunities for trainees, and allow for surgical case presentations. This study examined if a modified GoPro Hero 4 camera with a 25 mm lens could prove to be a cost-effective method of surgical videography with enough detail for oculoplastic and strabismus surgery. METHOD: The stock lens mount and lens were removed from a GoPro Hero 4 camera, and was refitted with a Peau Productions SuperMount and 25 mm lens...
2016: Clinical Ophthalmology
Shadi Rezai, Jenna T Nakagawa, John Tedesco, Annika Chadee, Sri Gottimukkala, Ray Mercado, Cassandra E Henderson
Background. Gestational gigantomastia is a rare disorder without clear etiology or well-established risk factors. Several pathogenic mechanisms contributing to the disease process have been proposed, all of which can lead to a similar phenotype of breast hypertrophy. Case. A 28-year-old Guinean woman presented at 37 weeks of gestation with bilateral gigantomastia, mastalgia, peau d'orange, and back pain. Prolactin levels were 103.3 μg/L (with a normal reference value for prolactin in pregnancy being 36-372 μg/L)...
2015: Case Reports in Obstetrics and Gynecology
Anthony H Loewen, Spencer D Schilling, Mary Milroy, Mary Lee Villanueva
Inflammatory breast cancer is a rare and aggressive disease found almost exclusively in women. We present a case of a 51-year-old male with inflammatory breast carcinoma. The patient presented with a mass measuring roughly 7 cm with overlying erythema, peau d'orange appearance, and prominent nipple retraction. Core biopsy analysis demonstrated estrogen and progesterone receptor positive, HER2/neu receptor negative invasive ductal carcinoma. A PET scan revealed contralateral supraclavicular lymph node metastasis...
October 2015: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Dipti Das, Anupam Das, Debabrata Bandyopadhyay, Dhiraj Kumar
Nevus lipomatosus cutaneous superficialis (NLCS) is a benign dermatosis, histologically characterized by the presence of mature ectopic adipocytes in the dermis. We hereby report a case of a 10-year-old boy who presented with multiple huge swellings on the scapular regions and lower back. The lesions were surmounted by small papules, along with peau-d orange appearance at places. Histology showed features consistent with NLCS. The case is being reported for the unusual clinical presentation.
May 2015: Indian Journal of Dermatology
Jason K Rivers
No abstract text is available yet for this article.
May 2015: Journal of Cutaneous Medicine and Surgery
Yuko Adachi, Yoko Mizutani, En Shu, Hiroyuki Kanoh, Tatsuhiko Miyazaki, Mariko Seishima
Eosinophilic fasciitis is clinically characterized by symmetrical scleroderma-like indurations of the skin with pain. The histological features are fascial inflammation with lymphocytes and eosinophils as well as thickened and fibrotic fascia. Lymphocytic infiltration and degeneration of the underlying muscle are rarely observed. We report a 69-year-old Japanese woman who presented with multiple areas of glossy induration and painful peau d'orange-like lesions on the chest and four extremities. T2-weighted magnetic resonance imaging showed significant hyperintense thickening of the fascia of the lower extremities...
January 2015: Case Reports in Dermatology
Lara Lacerda, Bisrat G Debeb, Daniel Smith, Richard Larson, Travis Solley, Wei Xu, Savitri Krishnamurthy, Yun Gong, Lawrence B Levy, Thomas Buchholz, Naoto T Ueno, Ann Klopp, Wendy A Woodward
INTRODUCTION: Inflammatory breast cancer (IBC) is an aggressive type of breast cancer, characterized by very rapid progression, enlargement of the breast, skin edema causing an orange peel appearance (peau d'orange), erythema, thickening, and dermal lymphatic invasion. It is characterized by E-cadherin overexpression in the primary and metastatic disease, but to date no robust molecular features that specifically identify IBC have been reported. Further, models that recapitulate all of these clinical findings are limited and as a result no studies have demonstrated modulation of these clinical features as opposed to simply tumor cell growth...
2015: Breast Cancer Research: BCR
Jennifer MacRitchie, Giulia Nuti
This article investigates the extent of production and perception of dynamic differences on a French historical harpsichord, extensively revised in 1788 by Pascal Taskin. A historical review reports on the descriptions of two different types of touch found in treatises of the 18th century. These two touches (loud/struck and soft/pressed) were used to perform single tones on the lower, upper, peau de buffle (PDB) registers (the last of which Taskin is credited with having invented) and the coupled 8-foot registers to investigate differences in dynamics...
2015: Frontiers in Psychology
Martin Gliem, Doris Hendig, Robert P Finger, Frank G Holz, Peter Charbel Issa
IMPORTANCE: Reticular pseudodrusen (RPD) are frequently associated with age-related macular degeneration and considered to be an independent risk factor for disease progression, but the pathophysiologic mechanisms are only incompletely understood. Therefore, it may be helpful to identify the associations of RPD with other diseases that have defined pathophysiologic mechanisms. OBJECTIVE: To describe the phenotype, prevalence, and topographic distribution of RPD in patients with pseudoxanthoma elasticum (PXE) and their association with a diseased Bruch membrane...
May 2015: JAMA Ophthalmology
Chitra Clive Ganta, Soumya Chatterjee, Brad Pohlman, Mehrnaz Hojjati
Chronic graft-versus-host disease (cGVHD) is one of the main late complications of allogeneic hematopoietic stem cell transplant and a major contributor to the mortality and morbidity in surviving recipients. Skin is the most common involved organ in cGVHD and may mimic a wide spectrum of dermatological conditions in its clinical and histopathologic manifestations. Some of the commonly simulated diseases are scleroderma, morphea, and lichen sclerosus. Chronic GVHD simulating eosinophilic fasciitis (EF) is relatively rare, frequently presenting with skin induration, a typical "peau d'orange" appearance, peripheral blood eosinophilia, myalgia, arthralgia, and arthritis leading to joint contractures in severe cases...
March 2015: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Martin A Nzegwu, Emmanuel Sule, Joseph Uzoigwe, Franklyn Achi
Metaplastic breast carcinoma (MBC) is a rare heterogeneous malignancy, accounting for <1% of all invasive breast carcinomas, in which adenocarcinoma is found to coexist with an admixture of spindle, squamous, chondroid or bone-forming neoplastic cells. Melanocytic variant was first described by Ruffolo et al. in 1997. We report a case of MBC, melanocytic variant, in a 57-year-old Nigerian female who presented with a left breast mass 8 cm in diameter in the upper outer quadrant, hard and gradually increase in size to become painful...
2015: Journal of Surgical Case Reports
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