Daniel Mukadi-Bamuleka, Junior Bulabula-Penge, Bart K M Jacobs, Anja De Weggheleire, François Edidi-Atani, Fabrice Mambu-Mbika, Anaïs Legand, John D Klena, Peter N Fonjungo, Placide Mbala-Kingebeni, Sheila Makiala-Mandanda, Masahiro Kajihara, Ayato Takada, Joel M Montgomery, Pierre Formenty, Jean-Jacques Muyembe-Tamfum, Kevin K Ariën, Johan van Griensven, Steve Ahuka-Mundeke
BACKGROUND: Ebola virus disease (EVD) outbreaks have emerged in Central and West Africa. EVD diagnosis relies principally on RT-PCR testing with GeneXpert®, which has logistical and cost restrictions at the peripheral level of the health system. Rapid diagnostic tests (RDTs) would offer a valuable alternative at the point-of-care to reduce the turn-around time, if they show good performance characteristics. We evaluated the performance of four EVD RDTs against the reference standard GeneXpert® on stored EVD positive and negative blood samples collected between 2018 and 2021 from outbreaks in eastern Democratic Republic of the Congo (DRC)...
April 19, 2023: EBioMedicine