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Lotte Christine Groth Hoegberg, Cecilie Christiansen, Jesper Soe, Rasmus Telving, Mette Findal Andreasen, Dan Staerk, Lona Louring Christrup, Kenneth Thermann Kongstad
OBJECTIVE: The spread of new psychoactive substances (NPS) has expanded rapidly in the last decade. The complexity of the pharmacological effects of NPS challenges the traditional treatment guidelines, and information of the emergence of new arrivals is valuable. Our knowledge on the actual range of recreational drugs used and NPS available in Denmark is limited as identification is possible only when consumers become patients in the healthcare system or through drug seizures. We aimed to detect classical recreational drugs and NPS in the urine of music festival attendees and evaluate if the use of NPS could have been predicted by comparing study data with drug seizure data from the previous year published by European and Danish health authorities...
August 17, 2017: Clinical Toxicology
(no author information available yet)
Eric Woolf, Ajai Chaudhary and Sheila Breidinger from Merck, spoke to Sankeetha Nadarajah (Commissioning Editor, Bioanalysis) about outsourcing strategy implementation.
August 10, 2017: Bioanalysis
(no author information available yet)
Christopher Bailey (AstraZeneca) and Lee Goodwin (Covance) speak to Sankeetha Nadarajah (Managing Commissioning Editor, Bioanalysis) about the evolution of the Pharma-CRO working relationship between AstraZeneca and Covance.
August 10, 2017: Bioanalysis
Jia-Li Liu, Zhi-Ling Tang, Ying Zhuo, Yaqin Chai, Ruo Yuan
As the only endogenous co-reactant in ECL system, the dissolved O2 was the ideal candidate due to the mild reaction and easy operation, but compared to S2O82-, the dissolved O2 with weaker redox activity suffers from the poor enhancement effect of luminophore, which restricted the further application in bioanalysis. Here, a high-intense ECL signal was gained by the employing of Pt nanomaterials as co-reaction accelerator to generate more intermediate of dissolved O2 to promote the co-reaction efficiency. Based on a new ternary ECL system of Pt nanomaterials as the co-reaction accelerator, dissolved O2 as co-reactant, and a neotype rubrene microrods as luminophore, an efficient "on-off-on" solid-state ECL switch platfrom was designed for ultrasensitive microRNA (miRNA) detection with a background reduction strategy of ferrocene-labeled single-stranded DNA (Fc-DNA) as a quencher...
August 7, 2017: Analytical Chemistry
Haiyin Li, Chuanfeng Wang, Ting Hou, Feng Li
The development of ultrasensitive and highly selective fluorescence biosensors for diverse analytes is highly desirable but remains a challenge. It is attributable to the scarcity of fluorogens with promising brightness, stability, and nontoxicity, which primarily determine the performance of fluorescence biosensors. Herein, we report the design and preparation of aggregation induced emission (AIE) dots with high brightness, exceptional colloidal stability, ultrasmall size, and functional groups for developing ultrasensitive biosensor through the electrostatic conjugation to biological molecules, and use blemycin (BLM) as the proof-of-concept analyte...
August 18, 2017: Analytical Chemistry
Jens Sydor, Grace Kim
No abstract text is available yet for this article.
August 2, 2017: Bioanalysis
Amy Craddock, Sankeetha Nadarajah
No abstract text is available yet for this article.
August 2, 2017: Bioanalysis
Barry van der Strate, Robin Longdin, Marie Geerlings, Nora Bachmayer, Maria Cavallin, Virginia Litwin, Minesh Patel, Wilfried Passe-Coutrin, Corinna Schoelch, Arjen Companjen, Marianne Scheel Fjording
Flow cytometry is a powerful tool that can be used for the support of (pre)clinical studies. Although various white papers are available that describe the set-up and validation of the instrumentation (the flow cytometer) and validation of flow cytometry methods, to date no guidelines exist that address the requirements for performing flow cytometry in a regulated environment. In this manuscript, the European Bioanalysis Forum presents additional practice guidance on the use of flow cytometry in the support of drug development programs and addresses areas that are not covered in the previous publications...
August 2, 2017: Bioanalysis
Neil Spooner, Melanie Anderson, Lieve Dillen, Luca Ferrari, Martijn Hilhorst, Zamas Lam, Marco Michi, James Munday, John Smeraglia, Scott Summerfield, Dieter Zimmer
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
Yunlong Bai, Yapiao Li, Dapeng Zhang, Hailin Wang, Qiang Zhao
Aptamer affinity capillary electrophoresis-laser-induced fluorescence (CE-LIF) for protein detection takes advantage of aptamers for their ease of synthesis and labeling, small size, and having many negative charges. Its success relies on the high binding affinity of aptamers. One 15-mer DNA aptamer (5'-GGT TGG TGT GGT TGG-3', Apt15) shows desirable specificity for human α-thrombin, an important enzyme with multiple functions in blood. However, Apt15 has weak binding affinity, and the use of Apt15 in affinity CE-LIF analysis remains challenging...
August 16, 2017: Analytical Chemistry
Lee Abberley
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
Cecilia Arfvidsson, Paul Severin, Victoria Holmes, Richard Mitchell, Christopher Bailey, Stephanie Cape, Yan Li, Tammy Harter
The AstraZeneca and Covance Laboratories Clinical Bioanalysis Alliance (CBioA) was launched in 2011 after a period of global economic recession. In this challenging environment, AstraZeneca elected to move to a full and centralized outsourcing model that could optimize the number of people supporting bioanalytical work and reduce the analytical cost. This paper describes the key aspects of CBioA, the innovative operational model implemented, and our ways of ensuring this was much more than simply a cost reduction exercise...
August 1, 2017: Bioanalysis
Neil Simmons, John Lowe, Annelies Coddens
The 11th WRIB held in Los Angeles, CA, USA in April 2017. It drew over 750 professionals representing large Pharmas, Biotechs, CROs and multiple regulatory agencies from around the world, from the global bioanalytical community. Bioanalysis and Bioanalysis Zone are very proud to be supporting the WRIB Poster Awards again this year, and we feature the profiles of the authors of the winning posters. Visit to see the winning posters in full.
July 2017: Bioanalysis
Peng Zhang, Yuxin Liu
Sample enrichment or molecules concentration is considered as an essential step for sample processing in miniaturized devices aiming at biosensing and bioanalysis. Among all the means involved to achieve this aim, dielectrophoresis (DEP) is increasingly employed in molecules manipulation and concentration because it is non-destructive and high efficiency. This paper presents a methodology to achieve protein concentration utilizing the combination effects of electrokinetics and low frequency insulator-based dielectrophoresis (iDEP) generated within a microfluidic device, in which a submicron constricted channel was fabricated using DNA molecular combing and replica molding...
July 28, 2017: Biofabrication
Luís Pinto da Silva, Rui F J Pereira, Carla M Magalhães, Joaquim C G Esteves da Silva
The bioluminescent reaction of the "sea firefly" Cypridina hilgen-dorfii is a prototypical system for marine bioluminescence, as its substrate possesses an imidazopyrazinone core that is a common link among organisms of eight phyla. The elucidation of the mecha-nism behind Cypridina bioluminescence is essential for future applications in bioimaging, biomedicine and bioanalysis. In this study we have investigated the key step of chemiexcitation with a combined experimental and theoretical approach. The obtained results indicate that neutral dioxetanone is responsible for efficient chemiexcitation, as the thermolysis of this species gives access to a long region of the potential energy surface (PES), where the ground and excited singlet states are degenerated...
July 27, 2017: Journal of Physical Chemistry. B
Yuanjin Zhan, Jingjing Yan, Mei Wu, Longhua Guo, Zhenyu Lin, Bin Qiu, Guonan Chen, Kwok-Yin Wong
Hexagonal boron nitride nanosheets (BNNS), one kind of inorganic graphene analogue, exhibit high fluorescence quenching ability via the photo-induced electron transfer (PET) and different affinity toward single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). As a proof of concept, the BNNS was first used as a sensing platform for the rapid detection of DNA and small molecules with high sensitivity and selectivity in this study. This strategy is versatile and quick fluorescence sensing of DNA and extensive DNA related analytes such as metal cations and small molecules...
November 1, 2017: Talanta
Vinita Hooda, Anjum Gahlaut, Ashish Gothwal, Vikas Hooda
Bilirubin detection plays a major role in healthcare. Its high concentration in human serum is lethal and must be determined accurately. Clinically, it is vital for assessing patients with deleterious health conditions such as jaundice or icterus, hepatitis, mental disorders, cerebral palsy and brain damage especially in the case of neonates. In evaluating the drawbacks regarding the conventional methodology of bilirubin detection, there is need for a superior analytical tool. Bilirubin oxidase (BOx)-based sensors have been designed for the ultrasensitive analysis of bilirubin and quality deliverance of treatment and this review highlights the different mechanisms of bilirubin detection using different modified electrodes...
July 19, 2017: Biotechnology Letters
Ding Ding, Yiting Xu, Yuxiu Zou, Long Chen, Zhuo Chen, Weihong Tan
Graphitic nanocapsules are emerging nanomaterials which are gaining popularity along with the development of carbon nanomaterials. Their unique physical and chemical properties, as well as good biocompatibility, make them desirable agents for biomedical and bioanalytical applications. Through rational design, integrating graphitic nanocapsules with other materials provides them with additional properties which make them versatile nanoplatforms for bioanalysis. In this feature article, we present the use and performance of graphitic nanocapsules in a variety of bioanalytical applications...
August 3, 2017: Nanoscale
Ute Resch-Genger, Hans H Gorris
Lanthanide-doped photon-upconversion nanoparticles (UCNPs) have been the focus of many research activities in materials and life sciences in the last 15 years because of their potential to convert light between different spectral regions and their unique photophysical properties. To fully exploit the application potential of these fascinating nanomaterials, a number of challenges have to be overcome, such as the low brightness, particularly of small UCNPs, and the reliable quantification of the excitation-power-density-dependent upconversion luminescence...
July 14, 2017: Analytical and Bioanalytical Chemistry
Nozomu Koseki, Hiroko Ashizawa, Takuho Ishii, Takahide Uchimura, Keita Ono, Saori Kuriyama, Akiko Toda, Kuretake Soejima, Naoko Nakai, Naohiro Nishimura, Tsuyoshi Mayumi, Yutaka Yasuda, Tatsuya Yamakawa, Makoto Niwa
No abstract text is available yet for this article.
July 2017: Bioanalysis
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