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https://www.readbyqxmd.com/read/28091804/baseline-results-from-the-uk-signify-study-a-whole-body-mri-screening-study-in-tp53-mutation-carriers-and-matched-controls
#1
Sibel Saya, Emma Killick, Sarah Thomas, Natalie Taylor, Elizabeth K Bancroft, Jeanette Rothwell, Sarah Benafif, Alexander Dias, Christos Mikropoulos, Jenny Pope, Anthony Chamberlain, Ranga Gunapala, Louise Izatt, Lucy Side, Lisa Walker, Susan Tomkins, Jackie Cook, Julian Barwell, Vicki Wiles, Lauren Limb, Diana Eccles, Martin O Leach, Susan Shanley, Fiona J Gilbert, Helen Hanson, David Gallagher, Bala Rajashanker, Richard W Whitehouse, Dow-Mu Koh, S Aslam Sohaib, D Gareth Evans, Rosalind A Eeles
In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to investigate the role of one-off non-contrast whole-body MRI (WB MRI) in the screening of asymptomatic TP53 mutation carriers. 44 TP53 mutation carriers and 44 population controls were recruited. Scans were read by radiologists blinded to participant carrier status. The incidence of malignancies diagnosed in TP53 mutation carriers against general population controls was calculated...
January 16, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28091358/a-survey-of-exercise-advice-and-recommendations-in-united-kingdom-paediatric-cardiac-clinics
#2
Craig A Williams, Lucy Gowing, Richard Horn, Alan Graham Stuart
BACKGROUND: Physical activity and exercise have important health benefits for children and adolescents with CHD. The objective of this study was to survey the provision of advice and recommendations in United Kingdom paediatric CHD clinics. METHODS: A three-page questionnaire was sent out to paediatric cardiac consultants in the United Kingdom, paediatric consultants with expertise in cardiology, and nursing staff (Paediatricians with Expertise in Cardiology Special Interest Group), as well as all members of the British Congenital Cardiovascular Association...
January 16, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28089658/utility-of-body-mass-index-waist-to-height-ratio-and-cardiorespiratory-fitness-thresholds-for-identifying-cardiometabolic-risk-in-10-4-17-6-year-old-children
#3
Duncan S Buchan, Julien S Baker
OBJECTIVE: To examine the utility of Body Mass Index (BMI), Waist-to-Height-Ratio (WHtR) and cardiorespiratory fitness thresholds to identify cardiometabolic risk in youth. METHODS: Cross-sectional cardiometabolic risk factor variables on 534 children aged 10.4-17.6 years of age (52% boys) from the United Kingdom were used. Binary logistic regression and receiver operating characteristic curves were used to examine the utility of established age and gender specific thresholds for BMI, WHtR and cardiorespiratory fitness to identify individuals with increased cardiometabolic risk (increased clustered triglycerides, HDL-cholesterol, systolic blood pressure and glucose)...
January 12, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28089608/piloting-the-united-kingdom-prescribing-safety-assessment-with-pharmacist-prescribers-in-scotland
#4
Fiona Reid, Ailsa Power, Derek Stewart, Anne Watson, Leon Zlotos, Derna Campbell, Trudi McIntosh, Simon Maxwell
BACKGROUND: Prescribing is a complex task requiring considerable knowledge and skills. The Prescribing Safety Assessment (PSA) was developed by the British Pharmacological Society and the United Kingdom (UK) Medical Schools Council. Between February and June 2014, over 7000 final year medical students undertook the PSA, with an overall pass rate of 94%. Independent prescribing for suitably trained pharmacists was introduced in the UK in 2006. To date there has been little focus on any objective measures of prescribing safety...
January 6, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28088922/restricting-the-marketing-of-foods-and-non-alcoholic-beverages-to-children-in-south-africa-are-all-nutrient-profiling-models-the-same
#5
Mariaan Wicks, Hattie Wright, Edelweiss Wentzel-Viljoen
The WHO has called for governments to improve children's food environment by implementing restrictions on the marketing of 'unhealthy' foods to children. Nutrient profiling (NP) models are used to define 'unhealthy' foods and support child-directed food marketing regulations. The aim of the present study was to assess the suitability of the South African NP model (SANPM), developed and validated for health claim regulations, for child-directed food marketing regulations. The SANPM was compared with four NP models specifically developed for such regulations...
January 16, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28088673/relationship-between-neonatal-gastroschisis-and-maternal-body-mass-index-in-a-united-kingdom-population
#6
Joann Hale, Abigail Derbyshire, Alexander Taylor, Clive Osmond, Diana Wellesley, David T Howe
OBJECTIVE: It has been reported that gastroschisis is associated with low maternal body mass index (BMI). We tested this hypothesis in the UK. STUDY DESIGN: We studied cases of gastroschisis ascertained from the regional fetal congenital anomaly register. We compared each affected mother with two controls from the birth register and maternity database. The first control was the next mother to deliver in the hospital, representing the normal population of mothers...
December 15, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28088420/exploring-expert-opinion-on-the-practicality-and-effectiveness-of-biosecurity-measures-on-dairy-farms-in-the-united-kingdom-using-choice-modeling
#7
Orla Shortall, Martin Green, Marnie Brennan, Wendela Wapenaar, Jasmeet Kaler
Biosecurity, defined as a series of measures aiming to stop disease-causing agents entering or leaving an area where farm animals are present, is very important for the continuing economic viability of the United Kingdom dairy sector, and for animal welfare. This study gathered expert opinion from farmers, veterinarians, consultants, academics, and government and industry representatives on the practicality and effectiveness of different biosecurity measures on dairy farms. The study used best-worst scaling, a technique that allows for greater discrimination between choices and avoids the variability in interpretation associated with other methods, such as Likert scales and ranking methods...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28088109/carbetocin-versus-oxytocin-for-prevention-of-post-partum-haemorrhage-at-caesarean-section-in-the-united-kingdom-an-economic-impact-analysis
#8
Helen A van der Nelson, Tim Draycott, Dimitrios Siassakos, Christopher W H Yau, Anthony J Hatswell
OBJECTIVE: To determine the economic impact of the introduction of carbetocin for the prevention of postpartum haemorrhage (PPH) at caesarean section, compared to oxytocin. STUDY DESIGN: The model is a decision tree conducted from a UK National Health Service perspective. 1500 caesarean sections (both elective and emergency) were modelled over a 12 month period. Efficacy data was taken from a published Cochrane meta-analysis, and costs from NHS Reference costs, the British National Formulary and the NHS electronic Medicines Information Tool...
January 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28087404/mood-and-anxiety-disorders-precede-development-of-functional-gastrointestinal-disorders-in-patients-but-not-in-the-population
#9
Michael P Jones, Jan Tack, Lukas Van Oudenhove, Marjorie M Walker, Gerald Holtmann, Natasha A Koloski, Nicholas J Talley
BACKGROUND & AIMS: Understanding the interactions between brain and gastrointestinal disorders requires analysis of the order of disease onset. We analyzed data from 2 independent studies to determine the proportion of individuals with diagnoses of functional gastrointestinal disorders (FGIDs) before diagnoses of mood or anxiety disorders (gut to brain), and vice versa (brain to gut). METHODS: We collected data from a retrospective study of 4966 patients diagnosed with a FGID (irritable bowel syndrome, dyspepsia, or constipation) and mood or anxiety disorder at general practices in the United Kingdom (health care seekers) over an average period of 13...
January 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28086826/offering-patients-therapy-options-in-unplanned-start-options-implementation-of-an-educational-program-is-feasible-and-effective
#10
Anna Machowska, Mark Dominik Alscher, Satyanarayana Reddy Vanga, Michael Koch, Michael Aarup, Abdul Rashid Qureshi, Bengt Lindholm, Peter Rutherford
BACKGROUND: Patients with unplanned dialysis start (UPS) have worse clinical outcomes than non-UPS patients, and receive peritoneal dialysis (PD) less frequently. In the OPTiONS study of UPS patients, an educational programme (UPS-EP) aiming at improving care of UPS patients by facilitating care pathways and enabling informed choice of dialysis modality was implemented. We here report on impact of UPS-EP on modality choice and clinical outcomes in UPS patients. METHODS: This non-interventional, prospective, multi-center, observational study included 270 UPS patients from 26 centers in 6 European countries (Austria, Germany, Denmark, France, United Kingdom and Sweden) who prior to inclusion presented acutely, or were being followed by nephrologists but required urgent dialysis commencement by an acutely placed CVC or PD catheter...
January 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28081569/gender-incongruence-of-childhood-clinical-utility-and-stakeholder-agreement-with-the-world-health-organization-s-proposed-icd-11-criteria
#11
Titia F Beek, Peggy T Cohen-Kettenis, Walter P Bouman, Annelou L C de Vries, Thomas D Steensma, Gemma L Witcomb, Jon Arcelus, Christina Richards, Griet De Cuypere, Baudewijntje P C Kreukels
The World Health Organization (WHO) is revising the tenth version of the International Classification of Diseases and Related Health Problems (ICD-10). This includes a reconceptualization of the definition and positioning of Gender Incongruence of Childhood (GIC). This study aimed to: 1) collect the views of transgender individuals and professionals regarding the retention of the diagnosis; 2) see if the proposed GIC criteria were acceptable to transgender individuals and health care providers; 3) compare results between two countries with two different healthcare systems to see if these differences influence opinions regarding the GIC diagnosis; and 4) determine whether healthcare providers from high-income countries feel that the proposed criteria are clinically useful and easy to use...
2017: PloS One
https://www.readbyqxmd.com/read/28079863/the-modified-patient-enablement-instrument-a-portuguese-cross-cultural-adaptation-validity-and-reliability-study
#12
Mafalda Remelhe, Pedro M Teixeira, Irene Lopes, Luís Silva, Jaime Correia de Sousa
Enabling patients with asthma to obtain the knowledge, confidence and skills they need in order to assume a major role in the management of their disease is cost effective. It should be an integral part of any plan for long-term control of asthma. The modified Patient Enablement Instrument (mPEI) is an easily administered questionnaire that was adapted in the United Kingdom to measure patient enablement in asthma, but its applicability in Portugal is not known. Validity and reliability of questionnaires should be tested before use in settings different from those of the original version...
January 12, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28078205/reasoning-and-rehabilitation-cognitive-skills-programme-for-mentally-disordered-offenders-predictors-of-outcome
#13
Susan Young, Mrigendra Das, Gisli H Gudjonsson
AIM: To investigate factors predicting treatment completion and treatment outcome of the Reasoning and Rehabilitation Mental Health Programme (R&R2MHP) cognitive skills programme for mentally disordered offenders. METHODS: Secondary analysis of data previously obtained from 97 male patients who were sectioned and detained under the United Kingdom Mental Health Act in low, medium and high security hospitals and who had completed R&R2MHP. Predictors of treatment completion included background variables and five outcome measures: Four self-reported measures of violent attitudes, social problem-solving skills, reactive anger and locus of control and an objective measure of behaviour on the ward that was completed by staff...
December 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28077608/-holiday-sickness-reported-exploratory-outcome-of-over-500-united-kingdom-holidaymakers-with-travellers-diarrhoea
#14
Prof Aali J Sheen, M Saad B Zahid, Andrew Fagbemi, Catherine Fullwood, Kathryn Whitehead
AIMS: To ascertain any predictors of potential food poisoning pathogens and development of post-infective irritable bowel syndrome (IBS) in UK travellers. An analysis was undertaken on prospectively collected data on 527 patients reporting symptoms of suspected food poisoning between June 2012 and June 2015. MAIN OUTCOME MEASURES: Positive stool sample indicative of food poisoning pathogens and diagnosis of post-infective IBS. RESULTS: Data on 527 patients were examined...
January 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28077588/first-in-human-evaluation-of-the-safety-and-immunogenicity-of-an-intranasally-administered-replication-competent-sendai-virus-vectored-hiv-type-1-gag-vaccine-induction-of-potent-t-cell-or-antibody-responses-in-prime-boost-regimens
#15
Julien Nyombayire, Omu Anzala, Brian Gazzard, Etienne Karita, Philip Bergin, Peter Hayes, Jakub Kopycinski, Gloria Omosa-Manyonyi, Akil Jackson, Jean Bizimana, Bashir Farah, Eddy Sayeed, Christopher L Parks, Makoto Inoue, Takashi Hironaka, Hiroto Hara, Tsugumine Shu, Tetsuro Matano, Len Dally, Burc Barin, Harriet Park, Jill Gilmour, Angela Lombardo, Jean-Louis Excler, Patricia Fast, Dagna S Laufer, Josephine H Cox
BACKGROUND:  We report the first-in-human safety and immunogenicity assessment of a prototype intranasally administered, replication-competent Sendai virus (SeV)-vectored, human immunodeficiency virus type 1 (HIV-1) vaccine. METHODS:  Sixty-five HIV-1-uninfected adults in Kenya, Rwanda, and the United Kingdom were assigned to receive 1 of 4 prime-boost regimens (administered at 0 and 4 months, respectively; ratio of vaccine to placebo recipients, 12:4): priming with a lower-dose SeV-Gag given intranasally, followed by boosting with an adenovirus 35-vectored vaccine encoding HIV-1 Gag, reverse transcriptase, integrase, and Nef (Ad35-GRIN) given intramuscularly (SLA); priming with a higher-dose SeV-Gag given intranasally, followed by boosting with Ad35-GRIN given intramuscularly (SHA); priming with Ad35-GRIN given intramuscularly, followed by boosting with a higher-dose SeV-Gag given intranasally (ASH); and priming and boosting with a higher-dose SeV-Gag given intranasally (SHSH)...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28074681/community-based-exercise-in-the-context-of-hiv
#16
Anna Li, Taylor McCabe, Erin Silverstein, Stephanie Dragan, Nancy M Salbach, Mehdi Zobeiry, Sarah Beldick, Chris Godi, Kelly K O'Brien
OBJECTIVE: To identify factors to consider for developing and implementing a community-based exercise (CBE) program for people living with HIV (PLWH). METHODS: We conducted a qualitative descriptive study using semi-structured interviews with PLWH, rehabilitation professionals, and recreation providers from Canada and the United Kingdom. We asked participants to describe their experience with exercise, facilitators, and barriers to accessing and participating in exercise, and factors to consider in developing a CBE program for PLWH...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28072796/incidence-of-spontaneous-resorption-of-lumbar-disc-herniation-a-meta-analysis
#17
Ming Zhong, Jin-Tao Liu, Hong Jiang, Wen Mo, Peng-Fei Yu, Xiao-Chun Li, Rui Rui Xue
BACKGROUND: Lumbar disc herniation (LDH), a common disease, is often treated conservatively, frequently resulting in spontaneous resorption of the herniated disc. The incidence of this phenomenon, however, remains unknown. OBJECTIVE: To analyze the incidence of spontaneous resorption after conservative treatment of LDH using computed tomography and magnetic resonance imaging. STUDY DESIGN: Meta-analysis and systematic review of cohort studies...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072761/immediate-chest-x-ray-for-patients-at-risk-of-lung-cancer-presenting-in-primary-care-randomised-controlled-feasibility-trial
#18
Richard D Neal, Allan Barham, Emily Bongard, Rhiannon Tudor Edwards, Jim Fitzgibbon, Gareth Griffiths, Willie Hamilton, Kerenza Hood, Annmarie Nelson, David Parker, Cath Porter, Hayley Prout, Kirsty Roberts, Trevor Rogers, Emma Thomas-Jones, Angela Tod, Seow Tien Yeo, Chris N Hurt
BACKGROUND: Achieving earlier stage diagnosis is one option for improving lung cancer outcomes in the United Kingdom. Patients with lung cancer typically present with symptoms to general practitioners several times before referral or investigation. METHODS: We undertook a mixed methods feasibility individually randomised controlled trial (the ELCID trial) to assess the feasibility and inform the design of a definitive, fully powered, UK-wide, Phase III trial of lowering the threshold for urgent investigation of suspected lung cancer...
January 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28070853/is-the-association-between-education-and-fertility-postponement-causal-the-role-of-family-background-factors
#19
Felix C Tropf, Jornt J Mandemakers
A large body of literature has demonstrated a positive relationship between education and age at first birth. However, this relationship may be partly spurious because of family background factors that cannot be controlled for in most research designs. We investigate the extent to which education is causally related to later age at first birth in a large sample of female twins from the United Kingdom (N = 2,752). We present novel estimates using within-identical twin and biometric models. Our findings show that one year of additional schooling is associated with about one-half year later age at first birth in ordinary least squares (OLS) models...
January 9, 2017: Demography
https://www.readbyqxmd.com/read/28070339/approval-status-and-evidence-for-who-essential-medicines-for-children-in-the-united-states-united-kingdom-and-japan-a-cross-sectional-study
#20
Rumiko Shimazawa, Masayuki Ikeda
BACKGROUND: The WHO Model List of Essential Medicines for Children (EMLc) covers medicines for globally high-burden diseases. Regulatory approval in high-income countries ensures evidence and dosage form but usually focuses on diseases common in those countries and not in low- and middle-income countries. METHODS: This cross-sectional study assessed supporting evidence for the 346 medicines in the 5th WHO EMLc and their approval data from the United States, United Kingdom, and Japan...
2017: Journal of Pharmaceutical Policy and Practice
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