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https://www.readbyqxmd.com/read/29909178/the-effect-of-apoe-genotype-on-alzheimer-s-disease-risk-is-influenced-by-sex-and-docosahexaenoic-acid-status
#1
REVIEW
Matthew Pontifex, David Vauzour, Anne-Marie Minihane
An apolipoprotein E ε4 (APOE-ε4) genotype is the strongest common genetic determinant of Alzheimer's disease (AD). The pleiotropic nature of apolipoprotein E has made elucidation of the aetiological basis difficult to establish, which is further complicated by the fact that the penetrance of the APOE-ε4 allele is modulated by sex, age, and nutrition. A greater metabolic consequence of the APOE-ε4 allele is likely to contribute to the fact that two-thirds of AD patients are female. A higher tissue status of the marine n-3 fatty acid docosahexaenoic acid (DHA) is associated with a lower AD risk...
May 21, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29908753/abdominal-obesity-and-insulin-resistance-after-an-episode-of-acute-pancreatitis
#2
Ruma G Singh, Sayali A Pendharkar, Aya Cervantes, Jaelim Cho, Victor Miranda-Soberanis, Maxim S Petrov
BACKGROUND: Emerging evidence indicates that individuals after an episode of acute pancreatitis (AP) are at an increased risk of developing metabolic derangements. While the link between general obesity and insulin resistance (IR) is well established, only a few studies have investigated the association between abdominal obesity and IR. The aim of this study was to investigate the associations between abdominal obesity and several indices of IR in individuals after an episode of AP. METHODS: Patients were eligible for this cross-sectional study if they were previously admitted with a primary diagnosis of AP based on the recent international guidelines...
May 1, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29908458/body-burden-of-toxic-metals-and-rare-earth-elements-in-non-smokers-cigarette-smokers-and-electronic-cigarette-users
#3
Mihaela Badea, Octavio P Luzardo, Ana González-Antuña, Manuel Zumbado, Liliana Rogozea, Laura Floroian, Dana Alexandrescu, Marius Moga, Laura Gaman, Mariana Radoi, Luis D Boada, Luis Alberto Henríquez-Hernández
Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov (Romania), divided into three groups (non-smokers, cigarette smokers and electronic cigarettes smokers) were recruited to disclose the role of smoking on the human exposure to inorganic elements...
June 13, 2018: Environmental Research
https://www.readbyqxmd.com/read/29908072/glycyrrhizin-has-a-high-likelihood-to-be-a-victim-of-drug-drug-interactions-mediated-by-hepatic-oatp1b1-1b3
#4
Jiajia Dong, Olajide E Olaleye, Rongrong Jiang, Jing Li, Chuang Lu, Feifei Du, Fang Xu, Junling Yang, Fengqing Wang, Weiwei Jia, Chuan Li
BACKGROUND AND PURPOSE: Intravenous glycyrrhizin, having anti-inflammatory and hepatoprotective properties, is incorporated into the management of liver diseases in China. This investigation was designed to elucidate the molecular mechanism underlying hepatobiliary excretion of glycyrrhizin and to investigate its potential for drug-drug interactions on organic anion-transporting polypeptides (OATP)1B. EXPERIMENTAL APPROACH: Human hepatic transporters were characterized for glycyrrhizin at the cellular and vesicular levels and compared with rat hepatic transporters...
June 16, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29908069/serum-neurofilament-light-chain-levels-as-a-marker-of-upper-motor-neuron-degeneration-in-patients-with-amyotrophic-lateral-sclerosis
#5
Benjamin Gille, Maxim De Schaepdryver, Janne Goossens, Lieselot Dedeene, Joke De Vocht, Emanuela Oldoni, An Goris, Ludo Van Den Bosch, Bart Depreitere, Kristl G Claeys, Jos Tournoy, Philip Van Damme, Koen Poesen
AIMS: Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron degeneration disease with a diagnostic delay of about one year after symptoms onset. In ALS, blood neurofilament light chain (NfL) levels are elevated, but it is not entirely clear what drives this increase and what the diagnostic performance of serum NfL is in terms of predictive values and likelihood ratios. The aims of this study were to further explore the prognostic and diagnostic performances of serum NfL to discriminate between patients with ALS and ALS mimics, and to investigate the relationship between serum NfL with motor neuron degeneration...
June 16, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29908030/cutaneous-involvement-in-an-8-year-old-boy-with-ras-associated-autoimmune-leucoproliferative-disorder-rald
#6
A Giacaman, A Bauzá Alonso, J A Salinas Sanz, J L Dapena Díaz, R Ramos Asensio, L Ferrés Ramis, M A Durán Pastor, A Martín-Santiago
Ras-associated autoimmune leucoproliferative disorder (RALD) is a nonmalignant syndrome associated with somatic KRAS mutations. We report a patient with RALD and cutaneous lesions, the first such case reported, to our knowledge. An 8-year-old boy presented with erythematous plaques on his face and body, along with lymphadenopathies and spleen enlargement without systemic symptoms. An increased number of monocytes were found in skin biopsy, peripheral blood and bone marrow (BM). Juvenile myelomonocytic leukaemia (JMML) was suspected...
June 16, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29907185/density-measurement-of-demodex-canis-by-qpcr-and-analysis-of-serum-cytokine-levels-in-dogs-with-different-clinical-forms-of-demodicosis
#7
Naiani Domingos Gasparetto, Arleana do Bom Parto Ferreira Almeida, Luciano Nakazato, Eduardo Luzía França, Adenilda Cristina Honorio França, Danny Laura Gomes Fagundes, Juliano Bortolini, Valéria Régia Franco Sousa
OBJECTIVES: To quantify (by qPCR) the density of Demodex canis mites in the skin of dogs with demodicosis and in healthy dogs, as well as measuring the serum concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, and tumour necrosis factor-alfa (TNF-α). METHODS: Fifty-four dogs were divided into three groups: localized demodicosis (LD, n = 16), generalized demodicosis (GD, n = 22), and control group (CG, n = 16). All dogs were subjected to skin scraping, blood collection, and skin biopsy...
June 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29907164/optimizing-the-method-for-generation-of-integration-free-induced-pluripotent-stem-cells-from-human-peripheral-blood
#8
Haihui Gu, Xia Huang, Jing Xu, Lili Song, Shuping Liu, Xiao-Bing Zhang, Weiping Yuan, Yanxin Li
BACKGROUND: Generation of induced pluripotent stem cells (iPSCs) from human peripheral blood provides a convenient and low-invasive way to obtain patient-specific iPSCs. The episomal vector is one of the best approaches for reprogramming somatic cells to pluripotent status because of its simplicity and affordability. However, the efficiency of episomal vector reprogramming of adult peripheral blood cells is relatively low compared with cord blood and bone marrow cells. METHODS: In the present study, integration-free human iPSCs derived from peripheral blood were established via episomal technology...
June 15, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29907122/detection-of-bacterial-pathogens-in-clade-e-head-lice-collected-from-niger-s-refugees-in-algeria
#9
Meriem Louni, Nadia Amanzougaghene, Nassima Mana, Florence Fenollar, Didier Raoult, Idir Bitam, Oleg Mediannikov
BACKGROUND: Head lice, Pediculus humanus capitis, are obligate blood-sucking parasites. Phylogenetically, they occur in five divergent mitochondrial clades (A, D, B, C and E), each having a particular geographical distribution. Recent studies have revealed that head lice, as is the case of body lice, can act as a vector for louse-borne diseases. Here, we aimed to study the genetic diversity of head lice collected from Niger's refugees (migrant population) arriving in Algeria, northern Africa, and to look for louse-borne pathogens...
June 15, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29906498/discovering-time-trends-of-the-german-populations-exposure-to-contaminants-by-analysis-of-human-samples-of-the-german-environmental-specimen-bank-esb
#10
Thomas Göen, Dominik Lermen, Jörg Hildebrand, Martina Bartel-Steinbach, Till Weber, Marike Kolossa-Gehring
The German Environmental Specimen Bank (ESB) is a monitoring instrument of the German Federal Ministry for the Environment, Nature Conservationand Nuclear Safety. The permanent biobank facility is run since 1981 containing environmental and human samples from Germany. All samples are collected according to standard operating procedures (SOP). An annually standardized collection of human samples at four different regional sites of the country has been established since 1997. Routine sampling is done once a year, recruiting healthy non occupationally exposed students aged 20-29 years, in an equal gender distribution...
June 12, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29906300/new-treatment-criteria-for-preterm-hyperbilirubinemic-infants-in-japan
#11
Ichiro Morioka
In 1992, Kobe University proposed treatment criteria for hyperbilirubinemic newborns using total serum bilirubin and serum unbound bilirubin reference values. In the last decade, chronic bilirubin encephalopathy has found to develop in preterm infants in Japan because it can now be clinically diagnosed based on an abnormal signal of the globus pallidus in T2-weighted magnetic resonance imaging and abnormal findings of the auditory brainstem response with or without apparent hearing loss, along with physical findings of kinetic disorders with athetosis...
June 15, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29906223/new-mouse-model-of-pulmonary-hypertension-induced-by-respiratory-syncytial-virus-bronchiolitis
#12
Dai Kimura, Jordy Saravia, Sridhar Jaligama, Isabella McNamara, Luan D Vu, Ryan D Sullivan, Salvatore Mancarella, Dahui You, Stephania A Cormier
Pulmonary hypertension (PH) has been observed in up to 75% of infants with moderate to severe respiratory syncytial virus (RSV) bronchiolitis and is associated with significant morbidity and mortality in infants with congenital heart disease. The purpose of this study was to establish a mouse model of PH secondary to RSV bronchiolitis that mimics the disease etiology as it occurs in infants. Neonatal mice were infected with RSV at 5 days of age, and then re-infected 4 weeks later. Serum free medium was administered to age-matched mice as control...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905797/crucial-role-for-nox2-and-sleep-deprivation-in-aircraft-noise-induced-vascular-and-cerebral-oxidative-stress-inflammation-and-gene-regulation
#13
Swenja Kröller-Schön, Andreas Daiber, Sebastian Steven, Matthias Oelze, Katie Frenis, Sanela Kalinovic, Axel Heimann, Frank P Schmidt, Antonio Pinto, Miroslava Kvandova, Ksenija Vujacic-Mirski, Konstantina Filippou, Markus Dudek, Markus Bosmann, Matthias Klein, Tobias Bopp, Omar Hahad, Philipp S Wild, Katrin Frauenknecht, Axel Methner, Erwin R Schmidt, Steffen Rapp, Hanke Mollnau, Thomas Münzel
Aims: Aircraft noise causes endothelial dysfunction, oxidative stress, and inflammation. Transportation noise increases the incidence of coronary artery disease, hypertension, and stroke. The underlying mechanisms are not well understood. Herein, we investigated effects of phagocyte-type NADPH oxidase (Nox2) knockout and different noise protocols (around-the-clock, sleep/awake phase noise) on vascular and cerebral complications in mice. Methods and results: C57BL/6j and Nox2-/- (gp91phox-/-) mice were exposed to aircraft noise (maximum sound level of 85 dB(A), average sound pressure level of 72 dB(A)) around-the-clock or during sleep/awake phases for 1, 2, and 4 days...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29905681/time-domain-diffuse-correlation-spectroscopy-modeling-the-effects-of-laser-coherence-length-and-instrument-response-function
#14
Xiaojun Cheng, Davide Tamborini, Stefan A Carp, Oleg Shatrovoy, Bernhard Zimmerman, Danil Tyulmankov, Andrew Siegel, Megan Blackwell, Maria Angela Franceschini, David A Boas
Diffuse correlation spectroscopy (DCS) is an optical technique that non-invasively quantifies an index of blood flow (BFi ) by measuring the temporal autocorrelation function of the intensity fluctuations of light diffusely remitted from the tissue. Traditional DCS measurements use continuous wave (CW) lasers with coherence lengths longer than the photon path lengths in the sample to ensure that the diffusely remitted light is coherent and generates a speckle pattern. Recently, we proposed time domain DCS (TD-DCS) to allow measurements of the speckle fluctuations for specific path lengths of light through the tissue, which has the distinct advantage of permitting an analysis of selected long path lengths of light to improve the depth sensitivity of the measurement...
June 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29905559/-clinical-and-immunological-criteria-for-the-adverse-course-of-infectious-mononucleosis-in-children
#15
Ya Kolesnik, T Zharkova, O Rzhevskaya, T Kvaratskheliya, O Sorokina
The article presents the results of our own studies to determine the criteria for the adverse variants of the course of infectious mononucleosis (IM) in children. The study was conducted in the regional children's infectious clinical hospital in Kharkov. 161 children aged three to fifteen years were under observation with diagnosis of infectious moninucleosis. Out of 161 ill children, 140 (86.9%) had moderate severity of disease, and 21 (13.1%) had severe forms. All children were prescribed standard clinical and laboratory-instrumental examinations...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905053/-effect-of-human-adipose-derived-stem-cells-on-pressure-ulcer-healing-in-mouse
#16
Chengliang Deng, Zhiyuan Liu, Yuanzhen Yao, Ruichi Liu, Zairong Wei, Dali Wang
Objective: To investigate the effect of human adipose-derived stem cells (hADSCs) on pressure ulcers in mouse. Methods: The subcutaneous adipose tissue from voluntary donation was harvested. Then the hADSCs were isolated and cultured by mechanical isolation combined with typeⅠcollagenase digestion. The 3rd generation cells were identified by osteogenic, adipogenic, chondrogenic differentiations and flow cytometry. The platelet rich plasma (PRP) from peripheral blood donated by healthy volunteers was prepared by centrifugation...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904439/multiplexed-microsphere-suspension-array-assay-for-urine-mitochondrial-dna-typing-by-c-stretch-length-in-hypervariable-regions
#17
Kimiko Aoki, Hiroyuki Tanaka, Takashi Kawahara
Background: The standard method for personal identification and verification of urine samples in doping control is short tandem repeat (STR) analysis using nuclear DNA (nDNA). The DNA concentration of urine is very low and decreases under most conditions used for sample storage; therefore, the amount of DNA from cryopreserved urine samples may be insufficient for STR analysis. We aimed to establish a multiplexed assay for urine mitochondrial DNA typing containing only trace amounts of DNA, particularly for Japanese populations...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904410/influencing-factors-of-nt-probnp-level-inheart-failure-patients-with-different-cardiacfunctions-and-correlation-with-prognosis
#18
Liang Xu, Yanchun Chen, Yanni Ji, Song Yang
Factors influencing N-terminal pro-brain natriuretic peptide (NT-proBNP) level in heart failure patients with different cardiac functions were identified to explore the correlations with prognosis. Eighty heart failure patients with different cardiac functions treated in Yixing People's Hospital from January 2016 to June 2017 were selected, and divided into two groups (group with cardiac function in class II and below and group with cardiac function in class III and above), according to the cardiac function classification established by New York Heart Association (NYHA)...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904055/quantitative-in-vivo-whole-genome-motility-screen-reveals-novel-therapeutic-targets-to-block-cancer-metastasis
#19
Konstantin Stoletov, Lian Willetts, Robert J Paproski, David J Bond, Srijan Raha, Juan Jovel, Benjamin Adam, Amy E Robertson, Francis Wong, Emma Woolner, Deborah L Sosnowski, Tarek A Bismar, Gane Ka-Shu Wong, Andries Zijlstra, John D Lewis
Metastasis is the most lethal aspect of cancer, yet current therapeutic strategies do not target its key rate-limiting steps. We have previously shown that the entry of cancer cells into the blood stream, or intravasation, is highly dependent upon in vivo cancer cell motility, making it an attractive therapeutic target. To systemically identify genes required for tumor cell motility in an in vivo tumor microenvironment, we established a novel quantitative in vivo screening platform based on intravital imaging of human cancer metastasis in ex ovo avian embryos...
June 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29903719/electroacupuncture-a-new-approach-to-open-the-blood-brain-barrier-in-rats-recovering-from-middle-cerebral-artery-occlusion
#20
Jiangsong Zhang, Xianming Lin, Hui Zhou, Yuanyuan Chen, Shuangkai Xiao, Junyue Jiao, Yibin Zhao, Zhong Di
OBJECTIVE: To examine for an opening effect on the blood-brain barrier (BBB) in intact rats and rats with experimental ischaemia-reperfusion (I/R) during the recovery period after various electroacupuncture (EA) treatments with different time courses, and to determine whether there is a time-dependent effect. An additional objective was to determine whether this method could induce the penetration of nerve growth factor (NGF) through the BBB. METHODS: A middle cerebral artery occlusion (MCAO) model was first established...
June 14, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
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