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https://www.readbyqxmd.com/read/29694958/current-mechanistic-concepts-in-ischemia-and-reperfusion-injury
#1
Meng-Yu Wu, Giou-Teng Yiang, Wan-Ting Liao, Andy Po-Yi Tsai, Yeung-Leung Cheng, Pei-Wen Cheng, Chia-Ying Li, Chia-Jung Li
Ischemia-reperfusion injury is associated with serious clinical manifestations, including myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal dysfunction, systemic inflammatory response syndrome, and multiple organ dysfunction syndrome. Ischemia-reperfusion injury is a critical medical condition that poses an important therapeutic challenge for physicians. In this review article, we present recent advances focusing on the basic pathophysiology of ischemia-reperfusion injury, especially the involvement of reactive oxygen species and cell death pathways...
April 20, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29694830/celastrol-attenuates-symptoms-of-preeclampsia-in-rats-by-inhibiting-matrix-metalloproteinase-9
#2
Sha Xiao, Ming Zhang, Zhenzhen He, Deling Wang
Preeclampsia is reported in pregnant women around the world and often causes maternal/fetal mortality and morbidity. In the current study, we assessed the efficacy of celastrol on a rat preeclampsia model induced by Nω -nitro-L-arginine methyl ester hydrochloride (L-NAME). Pregnant rats were administered L-NAME to establish preeclampsia. A total of 48 animals were randomly assigned into 4 groups (n=12 each): control, control plus celastrol treatment (control+celastrol), preeclampsia, and preeclampsia plus celastrol...
April 22, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29692708/paradigm-shift-to-neuroimmunomodulation-for-translational-neuroprotection-in-stroke
#3
REVIEW
Diana Amantea, Rosaria Greco, Giuseppe Micieli, Giacinto Bagetta
The treatment of acute ischemic stroke is still an unresolved clinical problem since the only approved therapeutic intervention relies on early blood flow restoration through pharmacological thrombolysis, mechanical thrombus removal, or a combination of both strategies. Due to their numerous complications and to the narrow time-window for the intervention, only a minority of stroke patients can actually benefit from revascularization procedures, highlighting the urgent need of identifying novel strategies to prevent the progression of an irreversible damage in the ischemic penumbra...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29692590/hemolysis-area-a-new-parameter-of-erythrocyte-osmotic-fragility-for-screening-of-thalassemia-trait
#4
Thanusak Tatu, Denis Sweatman
BACKGROUND: One-tube osmotic fragility test (OFT) is widely used for screening thalassemia traits. Interobserver variation may occur with 0.36% NaCl-based OFT due to the naked eye result reading style. PURPOSE: The purpose of this study was to establish and evaluate the novel numerical OFT-based parameter, so-called hemolysis area (HA), in screening thalassemia traits. MATERIALS AND METHODS: The portable spectrophotometer was invented capable of calculating the HA values...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29692274/isolating-the-direct-effects-of-adverse-developmental-conditions-on-in-vivo-cardiovascular-function-at-adulthood-the-avian-model
#5
K L Skeffington, C Beck, N Itani, D A Giussani
It is now well accepted that exposure to adverse environmental conditions in utero can predispose a fetus to disease later in life. Using an avian model to study the programming of disease has a unique advantage as it allows isolation of the direct effects of adverse conditions on fetal physiology, without any confounding effects via the mother or placenta. However, experiments in avian models are limited by the lack of well-established surgical protocols for the adult bird, which we have established in this study...
April 25, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29692206/pilot-investigation-of-the-effect-of-carvedilol-on-stress-precipitated-smoking-lapse-behavior
#6
Terril L Verplaetse, Andrea H Weinberger, Rebecca L Ashare, Brian P Pittman, Julia M Shi, Jeanette M Tetrault, Meaghan Lavery, Sherry A McKee
INTRODUCTION: Separate α1- and β-adrenergic antagonists have shown efficacy in reducing nicotine-motivated behaviors in rodents and humans, supporting a role for the noradrenergic system in mediating the reinforcing properties of drugs of abuse. However, the effect of the combined α1- and β-adrenergic antagonist, carvedilol, on stress-related smoking is unknown. METHODS: Using a well-established human laboratory model of stress-precipitated smoking-lapse behavior, we examined whether carvedilol (0 or 50 mg/day; between subject, n=17 per group), administered to steady-state, would attenuate the ability to resist smoking following stress imagery (vs...
April 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29691899/droplet-digital-pcr-for-bcr-abl-p210-detecting-of-cml-a-high-sensitive-method-of-the-minimal-residual-disease-disease-progression
#7
Wen-Jun Wang, Chao-Feng Zheng, Zhuang Liu, Yan-Hong Tan, Xiu-Hua Chen, Bin-Liang Zhao, Guo-Xia Li, Zhi-Fang Xu, Fang-Gang Ren, Yao-Fang Zhang, Jian-Mei Chang, Hong-Wei Wang
OBJECTIVE: The present study intended to establish a droplet digital PCR (dd-PCR) for monitoring minimal residual disease (MRD) in patients with BCR/ABL (P210)-positive CML, thereby achieving deep-level monitoring of tumor load and determining the efficacy for guided clinically individualized treatment. METHODS: Using dd-PCR and RT-qPCR, two cell suspensions were obtained from K562 cells and normal peripheral blood mononuclear cells by gradient dilution and were measured at the cellular level...
April 25, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29691787/the-role-of-circle-of-willis-anatomy-variations-in-cardio-embolic-stroke-a-patient-specific-simulation-based-study
#8
Debanjan Mukherjee, Neel D Jani, Jared Narvid, Shawn C Shadden
We describe a patient-specific simulation based investigation on the role of Circle of Willis anatomy in cardioembolic stroke. Our simulation framework consists of medical image-driven modeling of patient anatomy including the Circle, 3D blood flow simulation through patient vasculature, embolus transport modeling using a discrete particle dynamics technique, and a sampling based approach to incorporate parametric variations. A total of 24 (four patients and six Circle anatomies including the complete Circle) models were considered, with cardiogenic emboli of varying sizes and compositions released virtually and tracked to compute distribution to the brain...
April 24, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29691426/quantitative-shadow-compensated-optical-coherence-tomography-of-choroidal-vasculature
#9
Kiran Kumar Vupparaboina, Kunal K Dansingani, Abhilash Goud, Mohammed Abdul Rasheed, Fayez Jawed, Soumya Jana, Ashutosh Richhariya, Bailey K Freund, Jay Chhablani
Conventionally rendered optical coherence tomography (OCT) images of the posterior segment contain shadows which influence the visualization of deep structures such as the choroid. The purpose of this study was to determine whether OCT shadow compensation (SC) alters the appearance of the choroid and the apparent choroidal vascularity index (CVI), an OCT-derived estimated ratio of luminal to total choroidal volume. All scans were shadow compensated using a previously published algorithm, binarized using a novel validated algorithm and extracted binarized choroid to estimate CVI...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691297/validation-of-a-plasma-based-comprehensive-cancer-genotyping-assay-utilizing-orthogonal-tissue-and-plasma-based-methodologies
#10
Justin I Odegaard, John J Vincent, Stefanie Mortimer, James V Vowles, Bryan C Ulrich, Kimberly C Banks, Stephen R Fairclough, Oliver A Zill, Marcin Sikora, Reza Mokhtari, Diana Abdueva, Rebecca J Nagy, Christine E Lee, Lesli A Kiedrowski, Cloud P Paweletz, Helmy Eltoukhy, Richard B Lanman, Darya I Chudova, AmirAli Talasaz
PURPOSE: Liquid biopsies are powerful tools that enable non-invasive genotyping of advanced solid tumors; however, comprehensive, structured validation studies employing validated orthogonal comparator methods are lacking. EXPERIMENTAL DESIGN: Analytical validation was conducted according to established principles and guidelines. Blood-to-blood clinical validation comprised blinded external comparison to clinical digital droplet PCR across 222 consecutive biomarker-positive clinical samples...
April 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29690700/-the-state-of-the-art-research-findings-on-the-relationship-between-chronic-periodontitis-and-alzheimer-s-disease-a-review
#11
X S Qian, S Ge
Along with the development of periodontal medicine, there is a growing number of evidence showing that periodontitis could influence systemic health. Periodontitis is a chronic inflammatory disease caused by microbial infection mediated by dental plaque. Periodontal pathogenic microorganisms and its toxic products can disseminate through the blood stream or may cause the host immune response, which may lead to pathological changes of cerebral vessels and brain tissues to establish connection with Alzheimer's disease (AD)...
April 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29690697/-experimental-study-on-the-transforming-growth-factor-%C3%AE-3-combined-with-dental-pulp-stem-cells-in-early-bone-integration-of-implant
#12
Ababaikeli Guzalinuer, Huojia Muhetaer, H Wu, Abudureheman Paerhati
Objective: To establish the experimental model of rabbit mandibular anterior implant repair and evaluate the effects of transforming growth factor (TGF)-β3 and dental pulp stem cells (DPSC) in promoting the bone integration of implant. Methods: The New Zealand rabbits were randomly divided into experimental group, control group and blank group (6 rabbits for each group) . In the experimental group, the implant area was filled with the mixture of TGF-β3, DPSC and Bio-oss powder. In the control group, the implant area was filled with the mixture of DPSC and Bio-oss powder...
April 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29687876/the-intervention-of-enalapril-maleate-and-folic-acid-tablet-on-the-expressions-of-the-grp78-and-chop-and-vascular-remodeling-in-the-vascular-smooth-muscle-cells-of-h-hypertensive-rats-with-homocysteine
#13
F Lu, L-Y Zhao, Z-M Zhang, Q Zou, X-L Yu, C-Y Wei
OBJECTIVE: GRP78 and CHOP play essential roles in endoplasmic reticulum stress (ERS) of the vascular smooth muscle cells. We aim to investigate the effect of enalapril maleate and folic acid tablet on the expressions of GRP78 and CHOP and vascular remodeling in a homocysteine (HCY)-treated hypertensive rat model. MATERIALS AND METHODS: The hypertensive rat model was established with the technique of coarctation in the abdominal aorta, and the blood pressure of the rat was measured with the non-destructive tail-cuff method two weeks after operation...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687874/effects-of-platelet-rich-plasma-on-angiogenesis-and-osteogenesis-associated-factors-in-rabbits-with-avascular-necrosis-of-the-femoral-head
#14
X-L Zhang, K-Q Shi, P-T Jia, L-H Jiang, Y-H Liu, X Chen, Z-Y Zhou, Y-X Li, L-S Wang
OBJECTIVE: Platelet-rich plasma (PRP) contains various growth factors and cytokines that can enhance the recovery of the damaged tissues. The present study aimed to examine the effects of PRP on the recovery of avascular necrosis of the femoral head (ANFH), and to provide novel insights into the clinical treatment of this disease. MATERIALS AND METHODS: A total of 24 New Zealand white rabbits were randomly divided into the normal control group, ANFH model and PRP-treated groups (n =1 2 each)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687788/new-records-of-philometrids-nematoda-philometridae-from-marine-fishes-off-australia-including-description-of-four-new-species-and-erection-of-digitiphilometroides-gen-n
#15
Frantisek Moravec, Diane P Barton
The following six species of the Philometridae (Nematoda: Dracunculoidea) were recorded from marine fishes off the northern coast of Australia in 2015 and 2016: Philometra arafurensis sp. n. and Philometra papillicaudata sp. n. from the ovary and the tissue behind the gills, respectively, of the emperor red snapper Lutjanus sebae (Cuvier); Philometra mawsonae sp. n. and Dentiphilometra malabarici sp. n. from the ovary and the tissue behind the gills, respectively, of the Malabar blood snapper Lutjanus malabaricus (Bloch et Schneider); Philometra sp...
April 16, 2018: Folia Parasitologica
https://www.readbyqxmd.com/read/29687768/diagnostics-and-antibiotic-therapy-for-spondylodiscitis
#16
Franka Lestin-Bernstein, Marc Tietke, Lutz Briedigkeit, Oliver Heese
PURPOSE: Spondylodiscitis as a rare disease has increased in recent years; there are only a few recommendations regarding the diagnostics and treatment. The objective of this retrospective study was to characterise these patients and identify factors for a favourable healing process - with an emphasis on antibiotic therapy. METHODOLOGY: Findings/treatment regimens for all patients with spondylodiscitis treated at a tertiary care hospital in 2012/2013 were recorded...
April 23, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29687617/noninvasive-assessment-of-autonomic-function-in-human-neonates-born-at-the-extremes-of-fetal-growth-spectrum
#17
Hasthi U Dissanayake, Rowena L McMullan, Adrienne Gordon, Ian D Caterson, David S Celermajer, Melinda Phang, Camille Raynes-Greenow, Michael R Skilton, Jaimie W Polson
Birth weight is associated with adult cardiovascular disease, such that those at both ends of the spectrum are at increased risk. This may be driven in part by modification to autonomic control, a mechanistic contributor to hypertension. However, birth weight is a relatively crude surrogate of fetal growth; and newborn body composition may more accurately identify the "at risk" infant. Accordingly, we sought to determine whether newborns with high or low body fat have altered autonomic control of vasomotor function and cardiac contractility...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29686815/the-effect-of-positive-end-expiratory-pressure-during-anesthesia-on-arterial-oxygen-saturation-after-surgery-in-patient-undergoing-cesarean-section
#18
Mahmood Ganjifard, Masoumeh Samii, Samaneh Kouzegaran, Amir Sabertanha
One of the major complications of general anesthesia in the recovery room is arterial oxygen desaturation and hypoxemia. Positive end-expiratory pressure (PEEP) can improve arterial oxygen saturation by increasing FRC. This study aims to evaluate the effects of applying PEEP on arterial oxygen saturation and hemodynamic parameters in the patient undergoing cesarean section in VALIASR hospital. In this double blind clinical trial we randomly allocated 120 patients of class1 and 2 ASA scheduled to undergoing cesarean section into 3 group (in 40)...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29686814/an-innovative-way-to-highlight-the-power-of-each-polymorphism-on-elite-athletes-phenotype-expression
#19
Valentina Contrò, Gabriella Schiera, Antonino Abbruzzo, Antonino Bianco, Alessandra Amato, Alessia Sacco, Alessandra Macchiarella, Antonio Palma, Patrizia Proia
The purpose of this study was to determine the probability of soccer players having the best genetic background that could increase performance, evaluating the polymorphism that are considered Performance Enhancing Polymorphism (PEPs) distributed on five genes: PPARα, PPARGC1A, NRF2, ACE e CKMM. Particularly, we investigated how each polymorphism works directly or through another polymorphism to distinguish elite athletes from non-athletic population. Sixty professional soccer players (age 22.5 ± 2.2) and sixty healthy volunteers (age 21...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29686791/lung-consolidation-as-a-rare-presentation-of-lymphoplasmacytic-lymphoma-with-extramedullary-waldenstr%C3%A3-m-s-macroglobulinemia
#20
Omar Abdulfattah, Ebad Ur Rahman, Bikash Bhattarai, Sumit Dahal, Zainab Alnafoosi, David Trauber, Danilo Enriquez, Frances Schmidt
Objectives : Lymphoplasmacytic lymphoma (LPL) is a mature B cell lymphoma that usually involves the bone marrow, spleen and lymph nodes. Extramedullary involvement, including the lung, is rarely reported. Case description : A 73-year-old female initially presented to our hospital complaining of productive cough of white-colour sputum for three weeks duration. She reported unintentional weight loss of ten pounds over the last five months. There was no history of haemoptysis, fever, night sweats, chills, recent infections or hospitalization...
2018: Journal of Community Hospital Internal Medicine Perspectives
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