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https://www.readbyqxmd.com/read/29777867/antibiotic-exposure-prior-to-respiratory-viral-infection-is-associated-with-progression-to-lower-respiratory-tract-disease-in-allogeneic-hematopoietic-cell-transplant-recipients
#1
Chikara Ogimi, Elizabeth M Krantz, Jonathan L Golob, Alpana Waghmare, Catherine Liu, Wendy M Leisenring, Christopher R Woodard, Sara Marquis, Jane M Kuypers, Keith R Jerome, Steven A Pergam, David N Fredricks, Mohamed L Sorror, Janet A Englund, Michael Boeckh
INTRODUCTION: Recent publications note an association between antibiotic exposure and respiratory viral infections (RVIs). Antibiotics affect microbiota and impair immune response against RVIs in mice, and low microbiome diversity is associated with pulmonary complications including viral lower respiratory tract disease (LRTD) in hematopoietic cell transplantation (HCT) recipients. In this study, we examined whether antibiotic exposure was associated with increased risk of disease progression in RVIs post-transplantation...
May 16, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29774166/hemostatic-state-augmented-with-platelet-indices-among-sudanese-diabetic-septic-foot
#2
Bashir Abdrhman Bashir, Mohamed Salih Ali
Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot. Methods: A case-control study was conducted during the period from July to September 2017 at Dr...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29765530/mean-platelet-volume-as-a-predictive-marker-for-venous-thromboembolism-in-patients-treated-for-hodgkin-lymphoma
#3
Joanna Rupa-Matysek, Lidia Gil, Marta Barańska, Dominik Dytfeld, Mieczysław Komarnicki
Mean platelet volume (MPV) is reported to be associated with the risk of venous thromboembolism (VTE) and mortality in patients with cancer. We sought to determine the association of MPV with symptomatic VTE occurrence in patients treated for newly diagnosed Hodgkin lymphoma (HL) and their outcomes. We retrospectively studied 167 consecutive adult patients treated with HL. During first-line treatment 12 (7.2%) patients developed VTE and 14 (8%) died within the observation period. The pre-chemotherapy values of MPV were significantly lower in VTE patients than those without (p=0...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29762825/the-prognostic-role-of-platelet-to-lymphocyte-ratio-and-mean-platelet-volume-in-critically-ill-patients
#4
A Yildiz, A Yigit, A R Benli
OBJECTIVE: The aim of this study was to identify the relationship between complete blood count parameters, mean platelet volume (MPV), and platelet to lymphocyte ratio (PLR) with mortality and hospitalization duration in critically ill patients. PATIENTS AND METHODS: A retrospective analysis was made of patients admitted to our tertiary adult i̇ntensive Care Unit (ICU) between January 2015 and January 2016. Hemoglobin (Hb), white blood cell (WBC), lymphocyte and platelet counts were obtained from the complete blood count performed at the time of admission...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29752840/hematological-and-immunological-reference-intervals-for-adult-population-in-the-state-of-amhara-ethiopia
#5
Bamlaku Enawgaw, Wubet Birhan, Molla Abebe, Betelihem Terefe, Habtamu Wondifraw Baynes, Tekalign Deressa, Mulugeta Melku
OBJECTIVE: Reference intervals (RIs) currently being used in Ethiopia are derived from western populations. Thus, this study aimed to establish locally derived hematological and immunological RIs. METHOD: The study was conducted in Amhara State, Ethiopia with a total of 967 (55.2% males) participants. 56.9% of males and 43.1% of females were eligible for hematological and immunological RI determination. A non-parametric test was used for the determination of upper (97...
May 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29752673/lead-exposure-is-associated-with-risk-of-impaired-coagulation-in-preschool-children-from-an-e-waste-recycling-area
#6
Zhijun Zeng, Xia Huo, Yu Zhang, Zhehong Xiao, Yuling Zhang, Xijin Xu
Environmental lead exposure leads to various deleterious effects on multiple organs and systems, including the hematopoietic system. To explore the effects of lead exposure on platelet indices in preschool children from an informal, lead-contaminated electronic waste (e-waste) recycling area, we collected venous blood samples from 466 preschool children (331 from an e-waste area (Guiyu) and 135 from a non-e-waste area (Haojiang)). Child blood lead levels (BLLs) were determined by graphite furnace atomic absorption spectrophotometry, while platelet indices were quantified using a Sysmex XT-1800i hematology analyzer...
May 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29749714/transcriptional-responses-of-the-marine-green-alga-micromonas-pusilla-and-an-infecting-prasinovirus-under-different-phosphate-conditions
#7
Charles Bachy, Christina J Charlesworth, Amy M Chan, Jan F Finke, Chee-Hong Wong, Chia-Lin Wei, Sebastian Sudek, Maureen L Coleman, Curtis A Suttle, Alexandra Z Worden
Prasinophytes are widespread marine algae for which responses to nutrient limitation and viral infection are not well understood. We studied the picoprasinophyte, Micromonas pusilla, grown under phosphate-replete (0.65±0.07 d-1 ) and 10-fold lower (low)-phosphate (0.11±0.04 d-1 ) conditions, and infected by the phycodnavirus MpV-SP1. Expression of 17% of Micromonas genes in uninfected cells differed by >1.5-fold (q<0.01) between nutrient conditions, with genes for P-metabolism and the uniquely-enriched Sel1-like repeat (SLR) family having higher relative transcript abundances, while phospholipid-synthesis genes were lower in low-P than P-replete...
May 11, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29735870/an-investigation-of-the-effects-of-the-mean-platelet-volume-platelet-distribution-width-platelet-lymphocyte-ratio-and-platelet-counts-on-mortality-in-patents-with-sepsis-who-applied-to-the-emergency-department
#8
M Orak, Y Karakoç, M Ustundag, Y Yildirim, M K Celen, C Güloglu
Aim: The aim of this study is to examine the role of the mean platelet volume (MPV), platelet distribution width (PDW), platelet/lymphocyte ratio (PLR), and platelet values for predicting mortality in patients with sepsis. Materials and Methods: This is a retrospective study, involving patients 18 years and above who were diagnosed with sepsis. Blood samples were analyzed for platelets characteristics (counts, MPV, PDW, and PLR). The patients were separated into two groups namely the survivors and deceased...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29725754/mean-platelet-volume-is-associated-with-serum-25-hydroxyvitamin-d-concentrations-in-patients-with-stable-coronary-artery-disease
#9
Ilona Korzonek-Szlacheta, Bartosz Hudzik, Justyna Nowak, Janusz Szkodzinski, Jolanta Nowak, Mariusz Gąsior, Barbara Zubelewicz-Szkodzinska
There is little published data on the association of platelet function and 25(OH)D concentration. We investigated the associations between mean platelet volume (MPV) and 25(OH)D concentration in patients with stable coronary artery disease. Study population was divided into three groups: group 1-25(OH)D < 10 ng/mL (N = 22), group 2-25(OH)D 10-20 ng/mL (N = 42), and group 3-25(OH)D > 20 ng/mL (N = 14). Study groups shared similar demographics. MPV values were the highest in group 1, moderate in group 2, and the lowest in group 3 (11...
May 3, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29720052/high-density-lipoprotein-mean-platelet-volume-and-uric-acid-as-biomarkers-for-outcomes-in-patients-with-sepsis-an-observational-study
#10
Luis Bolívar Montero-Chacón, Juan Ignacio Padilla-Cuadra, Sy Han Chiou, Gabriel Torrealba-Acosta
BACKGROUND: We conducted an observational study evaluating the association between uric acid, mean platelet volume (MPV), and high-density lipoprotein (HDL) with complications and outcomes of patients with sepsis in a critical care setting. METHODS: We followed patients with a diagnosis of severe sepsis and septic shock for a maximum of 28 days. Main outcomes assessed included length of stay (LOS), the need for renal replacement therapy (RRT), assisted mechanical ventilation (AMV), and vasopressor support as well as in-unit mortality...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29717406/effect-of-sleeve-gastrectomy-on-platelet-counts-and-mean-platelet-volumes
#11
Faruk Kutluturk, Zeki Ozsoy
BACKGROUND: Obesity is a chronic metabolic disorder associated with cardiovascular disease, characterized by a chronic proinflammatory and prothrombotic state. The size and hemostatic potential of circulating platelets (PLTs) differ, with larger PLTs containing more granules and producing greater amounts of vasoactive and prothrombotic factors. This study aimed to investigate the effect of laparoscopic sleeve gastrectomy (LSG) on PLT count and mean platelet volume (MPV) in morbidly obese patients...
May 1, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29716700/prognostic-value-of-blood-count-parameters-in-patients-with-acute-coronary-syndrome
#12
Arsalan Majeed Adam, Ather Hasan Rizvi, Amna Haq, Rabia Naseem, Aiman Rehan, Ali Tariq Shaikh, Abdul Haseeb Abbas, Ansab Godil, Arif Ali, Muhammad Saad Ali Mallick, Muhammad Shahzeb Khan, Muhammad Nawaz Lashari
BACKGROUND: Recent studies have shown that complete blood count (CBC) parameters can effectively predict long-term mortality and re-infarction rates in acute coronary syndrome (ACS). However, the role of these parameters in predicting short term mortality has not been studied extensively. The main objective of this study was to determine whether CBC parameters can predict 30-days mortality and the incidence of major adverse cardiac event (MACE) in ACS patients. METHODOLOGY: A total of 297 patients with ACS were recruited in this prospective study...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29713769/optic-radiations-are-thinner-and-show-signs-of-iron-deposition-in-patients-with-long-standing-remitting-relapsing-multiple-sclerosis-an-enhanced-t-2-weighted-angiography-imaging-study
#13
Chun Zeng, Silin Du, Yongliang Han, Jialiang Fu, Qi Luo, Yayun Xiang, Xiaoya Chen, Tianyou Luo, Yongmei Li, Yineng Zheng
OBJECTIVE: This study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T2 * -weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions. METHODS: Fifty-one RRMS patients (42 patients with a disease duration [DD] ≥ 2 years [group Mor], nine patients with a DD < 2 years [group Les]) and 51 healthy controls (group Con) underwent conventional magnetic resonance imaging (MRI) and ESWAN at 3...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29713159/the-impact-of-exposure-to-biomass-smoke-versus-cigarette-smoke-on-inflammatory-markers-and-pulmonary-function-parameters-in-patients-with-chronic-respiratory-failure
#14
Birsen Ocakli, Eylem Acarturk, Emine Aksoy, Sinem Gungor, Fulya Ciyiltepe, Selahattin Oztas, Ipek Ozmen, Meltem Coban Agca, Cuneyt Salturk, Nalan Adiguzel, Zuhal Karakurt
Purpose: The aim of this study was to evaluate the impact of exposure to biomass smoke vs cigarette smoke on serum inflammatory markers and pulmonary function parameters in patients with chronic respiratory failure (CRF). Patients and methods: A total of 106 patients with CRF divided into age and gender-matched groups of cigarette-smoke exposure (n=55, mean [SD] age: 71.0 [12.0] years, 92.7% were females) and biomass smoke exposure (n=51, mean [SD] age: 73.0 [11...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29713026/low-mean-platelet-volume-is-associated-with-critical-limb-ischemia-in-peripheral-arterial-occlusive-disease
#15
Peter Rief, Reinhard B Raggam, Alexander Avian, Franz Hafner, Mahdi Sareban, Martin Wehrschuetz, Marianne Brodmann, Thomas Gary
Mean platelet volume (MPV) was recently published as a possible marker of coronary artery disease in patients at high risk for major adverse cardiac events. Because platelets play an important role in atherosclerosis, we examined the relationship between critical limb ischemia (CLI) and MPV in patients with peripheral arterial occlusive disease (PAOD). Our study comprised 2124 PAOD patients. Univariate logistic regression was performed to analyze potential predictors for CLI. Nagelkerke's R² is reported. Cross validation was performed using the leave-one-out principle...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29701174/mean-platelet-volume-platelet-count-ratio-and-mortality-in-patients-on-peritoneal-dialysis
#16
Yan Zhu, Fenfen Peng, Yihua Chen, Wenjing Chen, Weidong Zhou, Peilin Li, Hongxin Niu, Haibo Long
OBJECTIVES: The association between mean platelet volume/platelet count ratio (MPV/PC) and mortality has been demonstrated in various populations but not in peritoneal dialysis (PD) patients. This study investigated the association between MPV/PC and all-cause and cardiovascular mortality in PD patients. MATERIALS AND METHODS: In this single-center retrospective cohort study, 338 patients who underwent incident PD from January 2006 to June 2014 and had baseline MPV/PC were enrolled and followed until June 30, 2015...
April 27, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29698349/a-relationship-between-clinical-and-laboratory-characteristics-in-children-with-severe-scorpion-envenomation-in-%C3%A3-ukurova-turkey
#17
Sinem S Gökay, Hayri L Yilmaz, Riza D Yildizdaş, Tuğçe Çelik, Faruk Ekinci, Özlem T Kendir, Özden Ö Horoz
OBJECTIVE: Scorpion stings are an important health problem in many parts of the world. The aim of this study was to retrospectively examine cases of scorpion stings to evaluate their epidemiological, clinical, and laboratory features and to determine strategies that can reduce morbidity and mortality in these cases. METHODS: Scorpion stings experienced by children between 2007 and 2013 were retrospectively reviewed. The patients were categorized into groups based on severities of toxicities, and demographic, clinical, and laboratory features were compared between the groups...
April 24, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29697933/comparison-of-inflammatory-markers-between-brucella-and-non-brucella-epididymo-orchitis
#18
Ali Cift, Mehmet Ozgur Yucel
OBJECTIVES: Brucellosis is a multi-system infectious disease that is associated with inflammation, which causes an increase in acute phase reactants. Hematological inflammatory markers of brucellosis include mean platelet volume (MPV), red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). In this study, we aimed to evaluate the diagnostic value of hematological inflammatory markers in Brucella epididymo-orchitis (BEO), and to investigate the utility of these markers for differential diagnosis from non-Brucella epididymo-orchitis (non-BEO)...
April 15, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29689031/platelet-distribution-width-in-hepatocellular-carcinoma
#19
Fenfen Guo, Xuan Zhu, Xue Qin
BACKGROUND Platelets and platelet activation are involved in the critical steps of tumor cell growth, metastasis, and angiogenesis. In this study, we analyzed the correlation between platelet distribution width (PDW) and hepatocellular carcinoma (HCC). MATERIAL AND METHODS HCC patients at the First Affiliated Hospital of Guangxi Medical University, China, from January 2017 to October 2017, were analyzed retrospectively. The control group comprised healthy persons at the hospital for medical check-ups during the same period...
April 24, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29687547/inflammatory-cell-indexes-as-preoperative-predictors-of-hospital-stay-in-open-elective-thoracic-surgery
#20
Panagiotis Paliogiannis, Giorgio C Ginesu, Cinzia Tanda, Claudio F Feo, Alessandro Fancellu, Alessandro G Fois, Arduino A Mangoni, Salvatore Sotgia, Ciriaco Carru, Alberto Porcu, Angelo Zinellu
BACKGROUND: Shorter and safer hospital stay (HS) is a desired outcome for patients undergoing thoracic surgery. The aim of the present study was to evaluate the predictive capacity of a series of pre-defined inflammatory cell indexes based on preoperative complete blood counts, towards length of HS in open elective thoracic surgery. METHODS: We retrospectively studied 157 consecutive patients undergoing open elective thoracic surgery. Preoperative neutrophil to lymphocyte, platelet to lymphocyte and lymphocyte to monocyte ratios were calculated, and the red cell distribution width and mean platelet volume were registered...
April 24, 2018: ANZ Journal of Surgery
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