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https://www.readbyqxmd.com/read/29333408/is-long-term-storage-of-cryopreserved-stem-cells-for-hematopoietic-stem-cell-transplantation-a-worthwhile-exercise-in-developing-countries
#1
Santhosh Kumar Devadas, Minal Khairnar, Sumathi S Hiregoudar, Shashank Ojha, Sachin Punatar, Alok Gupta, Anant Gokarn, Pallavi Bhole, Sadhana Kannan, Navin Khattry
Background: Stem cell units (SCUs) that are cryopreserved prior to both autologous and allogeneic hematopoietic stem cell transplants (for donor lymphocyte infusion) remain unused or partially used several times, and become an increased burden to blood banks/SCU repositories. Because of the scarcity of data regarding the duration for which the storage is useful, there is no general consensus regarding disposal of SCUs. Methods: We conducted a retrospective audit of SCU utilization in 435 patients who planned to undergo either autologous stem cell transplantation (auto-SCT) (N=239) or allogeneic stem cell transplantation (allo-SCT) (N=196) at a tertiary cancer care center between November 2007 to January 2015...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29330877/characterization-of-biologic-response-modifiers-in-the-supernatant-of-conventional-refrigerated-and-cryopreserved-platelets
#2
Lacey Johnson, Shereen Tan, Emily Jenkins, Ben Wood, Denese C Marks
BACKGROUND: Alternatives to room temperature storage of platelets (PLTs) are of interest to support blood banking logistics. The aim of this study was to compare the presence of biologic response modifiers (BRMs) in PLT concentrates stored under conventional room temperature conditions with refrigerated or cryopreserved PLTs. STUDY DESIGN AND METHODS: A three-arm pool-and-split study was carried out using buffy coat-derived PLTs stored in 30% plasma/70% SSP+. The three matched treatment arms were as follows: room temperature (20-24°C), cold (2-6°C), and cryopreserved (-80°C with DMSO)...
January 12, 2018: Transfusion
https://www.readbyqxmd.com/read/29324488/storage-injury-and-blood-transfusions-in-trauma-patients
#3
Peter M Spieth, Haibo Zhang
PURPOSE OF REVIEW: The aim of the present review was to concisely summarize recent studies and current knowledge about effects of red blood cell storage injury in trauma patients. RECENT FINDINGS: Despite a pathophysiological rationale for older packed red blood cells (PRBCs) being associated with adverse events in the host organism, recent large clinical trials failed to show negative effects of transfusion with older PRBCs on clinically relevant outcomes in mixed patient population...
January 10, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29310562/programmatic-changes-to-reduce-mortality-and-morbidity-in-humanitarian-congenital-cardiac-surgery
#4
Tyler J Wallen, George J Arnaoutakis, Randa Blenden, Rodrigo Soto
BACKGROUND: This report documents the outcomes of cardiac surgical mission trips organized by the International Children's Heart Foundation (ICHF), a nongovernmental organization that provides congenital heart surgery services to the developing world, and discusses factors associated with a reduction of mortality and morbidity in this setting. METHODS: A retrospective review of a prospectively maintained database was conducted to identify any patient who underwent surgical intervention during the course of an ICHF mission trip...
January 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29296771/red-blood-cells-in-hemorrhagic-shock-a-critical-role-for-glutaminolysis-in-fueling-alanine-transamination-in-rats
#5
Julie A Reisz, Anne L Slaughter, Rachel Culp-Hill, Ernest E Moore, Christopher C Silliman, Miguel Fragoso, Erik D Peltz, Kirk C Hansen, Anirban Banerjee, Angelo D'Alessandro
Red blood cells (RBCs) are the most abundant host cell in the human body and play a critical role in oxygen transport and systemic metabolic homeostasis. Hypoxic metabolic reprogramming of RBCs in response to high-altitude hypoxia or anaerobic storage in the blood bank has been extensively described. However, little is known about the RBC metabolism following hemorrhagic shock (HS), the most common preventable cause of death in trauma, the global leading cause of total life-years lost. Metabolomics analyses were performed through ultra-high pressure liquid chromatography-mass spectrometry on RBCs from Sprague-Dawley rats undergoing HS (mean arterial pressure [MAP], <30 mm Hg) in comparison with sham rats (MAP, >80 mm Hg)...
July 25, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296737/retrospective-analysis-of-capillary-hemoglobin-recovery-in-nearly-1%C3%A2-200%C3%A2-000-blood-donor-returns
#6
Pia Niittymäki, Mikko Arvas, Antti Larjo, Pirkko Mattila, Jarkko Ihalainen, Martti Syrjälä, Johanna Castrén, Jukka Partanen
Measuring the concentration of capillary hemoglobin (cHb) is a standard procedure before blood donation. To further assess the time period needed for cHb recovery after blood donation and to have a more in-depth understanding of features of recovery, we used data-mining tools in a large, retrospective data pool containing all 1 163 524 donor returns that took place in Finland in 2010 to 2015. The results show that the average recovery times for cHb to return back to the level preceding donation were substantially longer, over 200 days in all age groups, than were the minimum allowed donation intervals...
June 13, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289740/sequence-based-hla-a-b-c-dp-dq-and-dr-typing-of-714-adults-from-colombo-sri-lanka
#7
Alba Grifoni, Daniela Weiskopf, Cecilia S Lindestam Arlehamn, Michael Angelo, Shay Leary, John Sidney, April Frazier, Elizabeth Phillips, Simon Mallal, Steven J Mack, Rashmi Tippalagama, Suraj Goonewardana, Sunil Premawansa, Gayani Premawansa, Ananda Wijewickrama, Aruna D De Silva, Alessandro Sette
DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were not detected at any locus. Several alleles were found in more than 30% of individuals, including the class II alleles DPB1∗04:01, DPB1∗02:01, DQB1∗06:01 and DRB1∗07:01, and the class I alleles A∗33:03 and A∗24:02...
December 28, 2017: Human Immunology
https://www.readbyqxmd.com/read/29288009/borrelia-persica-infection-in-rock-hyraxes
#8
Gabriela Kleinerman, Roni King, Yaarit Nachum-Biala, Gad Baneth
Tick-borne relapsing fever (TBRF) is an acute infectious disease caused by arthropod-borne spirochetes of the genus Borrelia and characterized by recurrent episodes of fever. Borrelia persica, the causative agent of this disease in Israel, is transmitted by the argasid tick Ornithodoros tholozani. There is little information about the maintenance and possible vertebrate reservoirs of B. persica in nature, but the tick O. tholozani is known to feed on animals that enter its habitat in caves, rock crevices and shady environments...
December 9, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29287058/activities-of-the-thor-aabb-working-party
#9
Mark H Yazer, Philip C Spinella
The AABB (formerly the American Association of Blood Banks) is an international authority on transfusion medicine and tissue banking. The Trauma, Hemostasis and Oxygenation Research (THOR) Network is an international multidisciplinary network of civilian and military providers ranging from first responders and medics to critical care physicians, and from basic scientists to clinical trialists. The THOR Network's vision is to improve outcomes from traumatic hemorrhagic shock by optimizing the acute phase of resuscitation...
December 28, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29285804/centrifugation-free-washing-a-novel-approach-for-removing-iga-from-stored-red-blood-cells
#10
Eszter Vörös, Nathaniel Z Piety, Briony C Strachan, Madeleine Lu, Sergey S Shevkoplyas
Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation-based cell processors commonly used by hospital blood banks cannot consistently reduce IgA below the recommended levels, hence double washing is frequently required. Here we describe a prototype of a simple, portable, disposable system capable of washing stored RBCs without centrifugation, while reducing IgA below 0.05 mg/dL in a single run. Samples from RBC units (n = 8, leukoreduced, 4-6 weeks storage duration) were diluted with normal saline to a hematocrit of 10%, and then washed using either the prototype washing system, or via conventional centrifugation...
December 29, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29283125/factors-affecting-the-serological-testing-of-cadaveric-donor-cornea
#11
Anuradha Raj, Garima Mittal, Harsh Bahadur
PURPOSE: The purpose of this study was to evaluate the serological profile of the eye donors and to study the influence of various factors on serological test results. METHODS: A cross-sectional, observational study was conducted, and data of 509 donors were reviewed from the records of eye bank from December 2012 to June 2017. Various details of donors analyzed included the age, sex of the donor, cause of death, source of tissue, time since blood collection after death, macroscopic appearance of blood sample, and details of discarded tissues...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29282441/platelet-transfusion-thresholds-among-children-admitted-to-a-pediatric-intensive-care-unit
#12
Batool Alsheikh, Madhuradhar Chegondi, Balagangadhar Totapally
Objective To evaluate the threshold for platelet transfusion in children admitted to a pediatric intensive care unit (PICU). This is a retrospective chart review study, conducted at our tertiary level PICU and is related to critically ill pediatric patients who required platelet transfusion. Methods We retrieved the target patient population data from our blood bank database. The patients were subdivided into four subgroups: hematologic (hematologic malignancies, bone marrow suppression, hemolytic anemia, and sickle cell disease), surgical (post-surgical, trauma and acute bleeding), the unstable fraction of inspired oxygen (FiO2 > 0...
October 24, 2017: Curēus
https://www.readbyqxmd.com/read/29280988/induced-pluripotent-stem-cell-derived-red-blood-cells-and-platelet-concentrates-from-bench-to-bedside
#13
REVIEW
Daniele Focosi, Giovanni Amabile
Red blood cells and platelets are anucleate blood components indispensable for oxygen delivery and hemostasis, respectively. Derivation of these blood elements from induced pluripotent stem (iPS) cells has the potential to develop blood donor-independent and genetic manipulation-prone products to complement or replace current transfusion banking, also minimizing the risk of alloimmunization. While the production of erythrocytes from iPS cells has challenges to overcome, such as differentiation into adult-type phenotype that functions properly after transfusion, platelet products are qualitatively and quantitatively approaching a clinically-applicable level owing to advances in expandable megakaryocyte (MK) lines, platelet-producing bioreactors, and novel reagents...
December 27, 2017: Cells
https://www.readbyqxmd.com/read/29279199/anti-m%C3%A3-llerian-hormone-amh-antral-follicle-count-afc-external-morphometrics-and-fertility-in-tabapu%C3%A3-cows
#14
Renata Maculan, Tássia Louregiani Carvalho Pinto, Gabriel Miranda Moreira, Gisvani Lopes de Vasconcelos, Jesus Afonso Sanches, Ricardo Garcia Rosa, Rafael Ribeiro Bonfim, Tarcisio de Moraes Gonçalves, José Camisão de Souza
The intense selection of characteristics related to animal performance may affect the reproductive efficiency of beef cows negatively. Selection for fertility along with production traits is, therefore, readily justifiable. The objective of the present study was to evaluate possible relationships among AFC, serum AMH concentrations and external morphometrics with reproductive efficiency in Tabapuã (a Brazilian Bos indicus beef breed) females. Antral follicle counts and external morphometrics were measured in nulliparous (n = 162), primiparous (n = 80) and multiparous (n = 351) cows, from four farms...
December 23, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29277913/unrelated-donor-choices-for-allogeneic-hematopoietic-cell-transplantation-in-canada-an-evaluation-of-factors-influencing-donor-selection
#15
Valerie Greco-Stewart, Jeffrey Kiernan, Donna Killeen, Sherry Haun, Dena Mercer, Kimberly Young, Robert S Liwski, David S Allan
BACKGROUND: Utilization of unrelated donors and cord blood units (CBUs) for allogeneic hematopoietic cell transplantation continues to increase. Understanding the practices of donor selection by transplant centers is critical for unrelated donor registries and cord blood banks to optimize registry composition and inventory to meet patient need. STUDY DESIGN AND METHODS: Unrelated donor and CBU selection practices of Canadian transplant centers served by Canadian Blood Services' OneMatch Stem Cell & Marrow Network (OM) were reviewed, including HLA match level, locus of disparity, age, sex, and product choice (donor vs...
December 25, 2017: Transfusion
https://www.readbyqxmd.com/read/29277499/-association-between-the-viruses-of-the-acquired-immunodeficiency-syndrome-and-the-hepatitis-c-virus-among-young-blood-donors-in-kinshasa-retrospective-analysis-of-10-years
#16
B M M Sumbu, B Longo-Mbenza, S Ahuka-Mundeke, J M Muwonga, G Mvumbi-Lelo, H M Maphana, D Kayembe Nzongola-Nkasu, F M Kalumbu
STUDY OBJECTIVES: The screening of anti-Human Immunodeficiency Virus antibodies is mandatory in every blood donor admitted to the Blood Bank of Kinshasa University Clinics since 1984. However, no compiled data are available to date. The objective of this study was to establish the trend, prevalence, viral co-infections, and determinants of Human Immunodeficiency anti-Virus serology in blood donors admitted between 2003-2006 and 2008-2013. PATIENTS AND METHODS: A retrospective analysis was carried out at University Kinshasa Clinics, using blood donors' records during 2003-2006 and 2008-2013...
December 22, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29276094/measures-of-blood-hemoglobin-and-hematocrit-during-cardiac-surgery-comparison-of-three-point-of-care-devices
#17
Nikolai V Kolotiniuk, Gerald R Manecke, Michael R Pinsky, Dalia Banks
OBJECTIVE: The primary objective was to compare I-Stat, HemoCue, and RapidLab in measurements of the hemoglobin concentration during cardiac surgeries using cardiopulmonary bypass. DESIGN: Prospective analysis. SETTING: Single-center, academic, tertiary care cardiovascular center. PARTICIPANTS: Thirty-four consecutive patients undergoing cardiac surgery requiring cardiopulmonary bypass. INTERVENTIONS: Blood samples have been collected intraoperatively, and the hemoglobin concentration in each sample was measured, or calculated, simultaneously by the 3 point-of-care devices, HemoCue, RapidLab, and I-Stat...
November 16, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29274116/risk-of-hla-homozygous-cord-blood-transplantation-implications-for-induced-pluripotent-stem-cell-banking-and-transplantation
#18
Yasuo Morishima, Fumihiro Azuma, Koichi Kashiwase, Kayoko Matsumoto, Takeshi Orihara, Hiromasa Yabe, Shunichi Kato, Koji Kato, Shunro Kai, Tetsuo Mori, Kazunori Nakajima, Satoko Morishima, Masahiro Satake, Minoko Takanashi, Toshio Yabe
Clinical application of induced pluripotent stem cells (iPS) in autologous settings has just begun. To overcome the high time and cost barriers in the individual production of autologous iPS, the use of allogeneic iPS with a homozygous human leukocyte antigen (HLA) haplotype (HLA-homo HP) has been proposed. Cord blood transplantation (CBT) is a suitable model for evaluating the allogeneic immunogenicity of iPS transplantation from HLA-homo donors. We analyzed 1,374 Japanese single cord blood transplant pairs who were retrospectively typed as HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1...
December 23, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29251713/microparticles-formed-during-storage-of-red-blood-cell-units-support-thrombin-generation
#19
Beth A Bouchard, Thomas Orfeo, Hollis N Keith, Elizabeth M Lavoie, Matthew Gissel, Mark Fung, Kenneth G Mann
BACKGROUND: Intact red blood cells (RBCs) appear to support thrombin generation in in vitro models of blood coagulation. During storage of RBC units, biochemical, structural and physiological changes occur including alterations to RBC membranes and release of microparticles, which are collectively known as storage lesion. The clinical consequences of microparticle formation in RBC units are unclear. This study was performed to assess thrombin generation via the prothrombinase complex by washed RBCs and RBC-derived microparticles as a function of RBC unit age...
December 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29251646/use-of-uncrossmatched-erythrocytes-in-emergency-bleeding-situations
#20
Mark H Yazer, Jonathan H Waters, Philip C Spinella, Col Andrew Cap, Capt Roland L Fahie, Emmett Gourdine, Donald H Jenkins, Steven Kleinman, Ernest E Moore, Paul Ness, Eilat Shinar, Steve R Sloan, James R Stubbs, Kevin R Ward
No abstract text is available yet for this article.
December 15, 2017: Anesthesiology
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