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https://www.readbyqxmd.com/read/28237471/pesticide-exposure-in-the-local-community-of-vehari-district-in-pakistan-an-assessment-of-knowledge-and-residues-in-human-blood
#1
Muhammad Farhan Saeed, Mussarat Shaheen, Iftikhar Ahmad, Ali Zakir, Muhammad Nadeem, Arif Ali Chishti, Muhammad Shahid, Khuda Bakhsh, Christos A Damalas
The present study is based on cross-sectional data collected from rural and market areas of Vehari District in Pakistan to assess public awareness of pesticide risks and determine the levels of exposure to organochlorine pesticides (OCPs) in the local community. Blood samples were collected from 56 volunteer donors (VDs) including children, female workers, farm workers involved in pesticide business, farm workers involved in pesticide spraying activities, and people who were living away from agricultural fields...
February 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28229475/first-cases-of-zika-virus-infected-us-blood-donors-outside-states-with-areas-of-active-transmission
#2
Phillip C Williamson, Jeffrey M Linnen, Debra A Kessler, Beth H Shaz, Hany Kamel, Ralph R Vassallo, Valerie Winkelman, Kui Gao, Rainer Ziermann, Juscilene Menezes, Stephen Thomas, Jerry A Holmberg, Sonia Bakkour, Mars Stone, Kai Lu, Graham Simmons, Michael P Busch
BACKGROUND: Zika virus (ZIKV) is transmitted by Aedes mosquitos and can result in severe congenital and adult neurologic abnormalities. ZIKV has rapidly spread northward through Central America and the Caribbean and autochthonous cases have been identified in the continental United States. High rates of ZIKA RNA positivity were detected in blood donors during previous epidemics. ZIKV transmission by transfused blood from healthy donor components has been a growing concern. STUDY DESIGN AND METHODS: Individual-donation aliquots of plasma from volunteer blood donors were tested individually with an investigational Procleix ZIKV assay...
February 23, 2017: Transfusion
https://www.readbyqxmd.com/read/28205426/a-study-of-hla-b-15-02-in-9-different-chinese-ethnics-implications-for-carbamazepine-related-sjs-ten
#3
G J Ou, J Wang, X Ji, H Yu, L Jiang, L Li, Q Chen, P C Su, Z Liu
BACKGROUND: HLA-B*15:02 is a known biomarker for carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in some ethnic populations. The US FDA recommends B*15:02 screening for Asian and other populations with a high prevalence of B*15:02 prior to treatment with CBZ to prevent drug-related SJS/TEN. MATERIALS AND METHODS: A total of 1607 blood samples were collected from volunteer blood donors who were ethnic minorities living in the Yunnan province of southwestern China, including 153 Yi, 193 Naxi, 167 Miao, 156 Lisu, 166 Derung, 211 Bai, 184 Hani, 198 Dai, and 179 Zhuang...
February 15, 2017: HLA
https://www.readbyqxmd.com/read/28194856/the-association-of-elevated-alanine-aminotransferase-levels-with-hepatitis-e-virus-infections-among-blood-donors-in-china
#4
Meiyu Wang, Miao He, Binting Wu, Ling Ke, Tingting Han, Jingxing Wang, Hua Shan, Paul Ness, Nan Guo, Yu Liu, Kenrad E Nelson
BACKGROUND: Transfusion transmission of hepatitis E virus (HEV) is an emerging health risk, yet blood donors are rarely screened for this pathogen. Many blood centers instituted screening of blood donors for elevated levels of alanine aminotransferase (ALT) levels to prevent hepatitis C virus, which has continued in China. We evaluated whether elevated ALT levels were associated with HEV among blood donors in China. STUDY DESIGN AND METHODS: Blood samples were collected from 9069 qualified volunteer blood donors from four blood centers in China...
February 2017: Transfusion
https://www.readbyqxmd.com/read/28137274/seroprevalence-and-geographical-distribution-of-human-t-lymphotropic-virus-type-1-among-volunteer-blood-donors-in-endemic-areas-of-iran
#5
Gharib Karimi, Maryam Zadsar, Ali Akbar Pourfathollah
BACKGROUND: Human T-cell lymphotrophic virus type 1 (HTLV-1) has a worldwide distribution and it is endemic in some regions of Iran. One of the most important routes of HTLV-1 transmission is via transfusion of contaminated blood components. The risk of transmission through asymptomatic blood donors, particularly in endemic areas should be considered and appropriately managed. The main objective of this study was to determine the seroprevalence and description the geographic distribution of HTLV-1 among voluntary blood donors in Iran...
January 30, 2017: Virology Journal
https://www.readbyqxmd.com/read/28112988/platelet-bioreactor-accelerated-evolution-of-design-and-manufacture
#6
Jonathan N Thon, Brad J Dykstra, Lea M Beaulieu
Platelets, responsible for clot formation and blood vessel repair, are produced by megakaryocytes in the bone marrow. Platelets are critical for hemostasis and wound healing, and are often provided following surgery, chemotherapy, and major trauma. Despite their importance, platelets today are derived exclusively from human volunteer donors. They have a shelf life of just five days, making platelet shortages common during long weekends, civic holidays, bad weather, and during major emergencies when platelets are needed most...
January 23, 2017: Platelets
https://www.readbyqxmd.com/read/28111924/awareness-of-cord-blood-collection-and-the-impact-on-banking
#7
Rusha Bhandari, Amy Lindley, Deepika Bhatla, Aleksandar Babic, Kathy Mueckl, Rakesh Rao, Paula Brooks, Vicki Geiler, Gilad Gross, Mohamad Al-Hosni, Shalini Shenoy
BACKGROUND: Umbilical cord blood (UCB) is an important source of hematopoietic stem cells for transplantation especially in minority populations with limited chances of finding a histocompatible volunteer donor in the registry. UCB has the advantages of early availability, successful outcomes despite some histocompatibility mismatch, and low incidence of chronic graft-versus-host disease. Public cord blood banks that disseminate UCB products for transplant depend on voluntary donation at participating hospitals and obstetrical providers for collection...
January 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28095288/cytomegalovirus-immunoglobulin-g-avidity-index-among-blood-donors-in-alexandria-egypt
#8
Aleya Abdel Gawad, Mona Hashish, Amani Abaza, Aisha El-Kayal
BACKGROUND: Transfusion transmitted diseases (TTD) are a major challenge to transfusion services all over the world. Cytomegalovirus (CMV) is considered one of the main viruses associated with blood transfusion. As CMV screening is not included in routine screening tests done for donated blood in blood banks in Egypt, the detection of CMV Immunoglobulin G (IgG) avidity needs to be tested for being a useful tool to diagnose recent infection among blood donors. The aim of this work was to study CMV IgG avidity index (AI) among blood donors...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28081120/epidemiology-of-chikungunya-virus-outbreaks-in-guadeloupe-and-martinique-2014-an-observational-study-in-volunteer-blood-donors
#9
Pierre Gallian, Isabelle Leparc-Goffart, Pascale Richard, Françoise Maire, Olivier Flusin, Rachid Djoudi, Jacques Chiaroni, Remi Charrel, Pierre Tiberghien, Xavier de Lamballerie
BACKGROUND: During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected cases. METHODS/PRINCIPAL FINDINGS: Individual testing for CHIKV RNA of all (n = 16,386) blood donations between Feb-24th 2014 and Jan-31st 2015 identified 0·36% and 0·42% of positives in Guadeloupe and Martinique, respectively...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28012709/the-history-and-challenges-of-blood-donor-screening-in-china
#10
REVIEW
Ling Li, Ka Yi Li, Ke Yan, Guojin Ou, Wenhui Li, Jue Wang, Ning Song, Li Tian, Xin Ji, Yongjun Chen, Xiaohua Liang, Zhong Liu, Yanyun Wu
Since the establishment of People's Republic of China in 1949, the Chinese government has encountered several catastrophes related to transfusion transmitted diseases. The government's increasing attention to blood safety has prompted the initiation of a series of policies and measures that have enhanced the level of safety for the blood supply and met the basic clinical demands of blood for 1.3 billion people in the country. Blood donation screening strategies in China predominantly comprise donor screening and donor testing...
November 12, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/27999757/ccl22-specific-t-cells-modulating-the-immunosuppressive-tumor-microenvironment
#11
Evelina Martinenaite, Shamaila Munir Ahmad, Morten Hansen, Özcan Met, Marie Wulff Westergaard, Stine Kiaer Larsen, Tobias Wirenfeldt Klausen, Marco Donia, Inge Marie Svane, Mads Hald Andersen
Tumor cells and tumor-infiltrating macrophages produce the chemokine CCL22, which attracts regulatory T cells (Tregs) into the tumor microenvironment, decreasing anticancer immunity. Here, we investigated the possibility of targeting CCL22-expressing cells by activating specific T cells. We analyzed the CCL22 protein signal sequence, identifying a human leukocyte antigen A2- (HLA-A2-) restricted peptide epitope, which we then used to stimulate peripheral blood mononuclear cells (PMBCs) to expand populations of CCL22-specific T cells in vitro...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27984397/donor-screening-experience-for-fecal-microbiota-transplantation-in-patients-with-recurrent-c-difficile-infection
#12
Raseen Tariq, Renee Weatherly, Patricia Kammer, Darrell S Pardi, Sahil Khanna
GOALS: To evaluate our experience with stool donor recruitment, screening, retention, and donor perception for fecal microbiota transplantation (FMT). BACKGROUND: Multiply recurrent Clostridium difficile infection is being increasingly managed with FMT from donor stools. However, donor selection and recruitment is challenging due to lack of standard evidence-based guidelines, donor exclusion criteria, frequency of screening and donor commitment. METHODS: Data on donors screened using institutional guidelines with history, blood and stool testing and their perspectives on donation were analyzed...
December 14, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27976504/a-novel-flow-cytometry-based-method-of-analyzing-heinz-bodies
#13
D Palasuwan, A Palasuwan, A Charoensappakit, E Noulsri
INTRODUCTION: Heinz bodies are important to diagnosing and managing patients. However, microscopic examination of Heinz bodies has several disadvantages, demonstrating the need for a better method. We explored the potential use of flow cytometry to examine Heinz bodies. METHODS: Whole-blood samples were collected from patients deficient in G6PD and healthy volunteers. Acetylphenylhydrazine was used to induce formation of Heinz bodies in red blood cells (RBCs). Then, RBCs positive for Heinz bodies were examined using a FACSCanto II cytometer...
February 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27959920/evaluation-of-stem-cell-derived-red-blood-cells-as-a-transfusion-product-using-a-novel-animal-model
#14
Sandeep N Shah, Monique P Gelderman, Emily M A Lewis, John Farrel, Francine Wood, Michael Brad Strader, Abdu I Alayash, Jaroslav G Vostal
Reliance on volunteer blood donors can lead to transfusion product shortages, and current liquid storage of red blood cells (RBCs) is associated with biochemical changes over time, known as 'the storage lesion'. Thus, there is a need for alternative sources of transfusable RBCs to supplement conventional blood donations. Extracorporeal production of stem cell-derived RBCs (stemRBCs) is a potential and yet untapped source of fresh, transfusable RBCs. A number of groups have attempted RBC differentiation from CD34+ cells...
2016: PloS One
https://www.readbyqxmd.com/read/27900761/the-effect-of-iron-balance-on-platelet-counts-in-blood-donors
#15
Anne F Eder, Yu Ying Yau, Kamille West
BACKGROUND: Thrombocytosis (or, less commonly, thrombocytopenia) is associated with iron-deficiency anemia and resolves with iron therapy. Many volunteer blood donors have low iron stores, with or without anemia. Iron balance could affect platelet counts in blood donors. STUDY DESIGN AND METHODS: Whole blood donors deferred for finger-stick hemoglobin levels less than 12.5 g/dL were evaluated by complete blood count and serum iron panel before and after oral iron treatment...
November 29, 2016: Transfusion
https://www.readbyqxmd.com/read/27866583/transfusion-medicine
#16
REVIEW
Nathan T Connell
Transfusion of various blood components can provide relief from symptomatic anemia and reduce the bleeding risks associated with low platelet counts or presence of coagulopathy. Blood components are collected from volunteer donors and processed into separate components to maximize efficient utilization of a scarce resource while also providing maximum clinical benefit. Tests including blood type and screening for clinically significant alloantibodies increase the likelihood of successful transfusion. Risks of transfusion include hypersensitivity and hemolytic transfusion reactions, transfusion-related acute lung injury, transfusion-associated circulatory overload, and transmission of infection...
December 2016: Primary Care
https://www.readbyqxmd.com/read/27814278/functional-analysis-of-serum-micrornas-mir-21-and-mir-106a-in-renal-cell-carcinoma
#17
Hamulati Tusong, Naibijiang Maolakuerban, Jin Guan, Mulati Rexiati, Wen-Guang Wang, Baihetiya Azhati, Yiliyaer Nuerrula, Yu-Jie Wang
OBJECTIVE: microRNAs (miRNAs) plays an important role in tumor development and progression and act as oncogenes or tumor suppressor genes in the carcinogenesis process. miRNA is stable in serum, and recent studies have demonstrated the feasibility of using circulating miRNA as biomarkers in cancer patients. However, currently, no serum biomarkers for the early diagnosis and prognosis of renal cell carcinoma (RCC) have been reported. Therefore, a new molecular marker for early diagnosis and evaluation of recurrence after surgery is required...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27809712/first-report-of-the-point-of-care-teg-a-technical-validation-study-of-the-teg-6s-system
#18
Paul A Gurbel, Kevin P Bliden, Udaya S Tantry, Amy L Monroe, Adina A Muresan, Norman E Brunner, Carlos G Lopez-Espina, Peter R Delmenico, Eli Cohen, Gabriel Raviv, DeAnna L Haugen, Mark H Ereth
Thrombelastography (TEG) measured by the TEG5000 Hemostasis Analyzer is an established but the labor-intensive method for assessing global hemostasis. The first true point-of-care TEG, the TEG6s system, uses resonance-frequency viscoelasticity measurements and a disposable multi-channel microfluidic cartridge to assess hemostasis and response to antiplatelet therapy. TEG assays (n = 5,100) were performed on the blood of healthy volunteers (n = 157) and patients undergoing coronary revascularization at three hospitals (n = 300)...
November 2016: Platelets
https://www.readbyqxmd.com/read/27802417/blood-pressure-lowering-effect-of-orally-ingested-nitrite-is-abolished-by-a-proton-pump-inhibitor
#19
Marcelo F Montenegro, Michaela L Sundqvist, Filip J Larsen, Zhengbing Zhuge, Mattias Carlström, Eddie Weitzberg, Jon O Lundberg
Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence the systemic effects of this anion. In a randomized, double-blind, placebo-controlled crossover study, we tested the effects of a proton pump inhibitor on the acute cardiovascular effects of nitrite. Fifteen healthy nonsmoking, normotensive subjects, aged 19 to 39 years, were pretreated with placebo or esomeprazole (3×40 mg) before ingesting sodium nitrite (0...
January 2017: Hypertension
https://www.readbyqxmd.com/read/27788761/umbilical-cord-blood-cells-from-unrelated-donor-as-an-alternative-source-of-hematopoietic-stem-cells-for-transplantation-in-children-and-adults
#20
REVIEW
Vanderson Rocha
Umbilical cord blood (CB) is an alternative source of hematopoietic stem cells (HSC) for patients requiring allogeneic HSC transplantation but lacking a suitable human leukocyte antigen (HLA)-matched donor. Using CB has many advantages, including lower HLA-matching requirements, increased donor availability, and low rates of graft-versus-host disease. Furthermore, with over 630,000 cryopreserved volunteer CB units currently stored in international CB banks worldwide, CB is rapidly available for those patients requiring urgent transplantation...
October 2016: Seminars in Hematology
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