keyword
MENU ▼
Read by QxMD icon Read
search

volunteer blood donor

keyword
https://www.readbyqxmd.com/read/29215846/-possibilities-of-correction-rheological-blood-svoytv-at-chipped-and-cut-wounds-of-the-breast
#1
V V Masljakov, O A Suhanova, V G Barsukov, K G Kurkin, S A Suhanov
The purpose: research objective: to study influence of electromagnetic oscillations of millimetric range on rheological properties of blood at patients with chipped and cut wounds of a breast for the purpose of their correction. Methods. For the solution of a research objective we have carried out studying of changes of rheological properties of blood at the 22nd patient with the getting chipped and cut wounds of a breast without internal injury during the next postoperative period. All patient has executed primary surgical processing and drainage of a pleural cavity...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29204089/subpopulations-of-natural-killer-t-like-cells-before-and-after-surgical-treatment-of-laryngeal-cancer
#2
Janusz Klatka, Ewelina Grywalska, Anna Hymos, Ewelina Krasowska, Michał Mielnik, Dorota Siwicka-Gieroba, Justyna Markowicz, Piotr Trojanowski, Witold Olszański, Jacek Roliński
Introduction: Tumours connected with head and neck comprise about 5% of all tumours. The most frequent histological type of laryngeal carcinoma is squamous cell carcinoma. Different research projects suggest that the role of T lymphocytes might be significant in tumour development. iNKT cells are a new subpopulation of T cells and show cytotoxic activity against tumours. iNKT cells participate in modulating the function of other cells which have anti-tumour properties and secrete cytokines, which have pro-inflammatory and anti-inflammatory effects...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29187094/organ-donation-registration-and-decision-making-among-current-blood-donors-in-the-netherlands
#3
Eva-Maria Merz, Katja van den Hurk, Wim L A M de Kort
INTRODUCTION: In the Netherlands, there is a constant shortage in donor organs, resulting in long waiting lists. The decision to register as organ donor is associated with several demographic, cultural, and personal factors. Previous research on attitudes and motivations toward blood and organ donations provided similar results. RESEARCH QUESTION: The current study investigated demographic, cultural, and personal determinants of organ donation registration among current Dutch blood donors...
September 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29146407/-hemogram-profile-and-interest-of-pre-donation-hemoglobin-measurement-in-blood-donors-in-the-northwest-region-of-morocco
#4
S Bakrim, A Ouarour, K Jaidann, M Benajiba, A Masrar
BACKGROUND: Blood donation in Morocco and more particularly in the northwest region is carried out without prior determination of the pre-donation hemoglobin. In addition, we note the lack of scientific research that reports data on the red blood cells, leukocytes and platelet lines in donated blood at the regional or even national level. AIMS: To study hemogram profile in blood donors taken from the Northwest region of Morocco in order to provide decision makers of the National Center of Blood Transfusion and Hematology with valid scientific arguments to complete the criteria to donate whole blood, by the hemogram...
November 13, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29102288/gene-identification-of-rare-b-a-blood-group
#5
Li-Xin Jiao, Jing-Ying Zhang, Lin Chen, Xiao-Li Yu, Yu Han, Fan Yang, Jiang-Hong Yu, Ling-Ling Liu, Yue Lang
OBJECTIVE: To study serologic and gene characteristics of the B(A) blood group of blood donation volunteers in Jilin Province, China. METHODS: ABO subgroups were identified by standard serologic techniques in ABO typing discrepancy samples from all donors at the Jilin Blood Center (410,354 non-repeat donors). DNA (deoxyribonucleic acid) was collected from each sample and PCR (polymerase chain reaction) was used to sequence exons 6 and 7 and intron 6, part 5 from the ABO subgroup samples...
September 11, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29097362/elevated-plasma-factor-ixa-activity-in-premenopausal-women-on-hormonal-contraception
#6
Pansakorn Tanratana, Paul Ellery, Pamela Westmark, Alan E Mast, John P Sheehan
OBJECTIVE: Combined oral contraceptives induce a reversible hypercoagulable state with an enhanced risk of venous thromboembolism, but the underlying mechanism(s) remain unclear. Subjects on combined oral contraceptives also demonstrate a characteristic resistance to APC (activated protein C) in the thrombin generation assay. Here, we report the potential role of plasma factor IXa (FIXa) as a mechanism for hormone-induced systemic hypercoagulability. APPROACH AND RESULTS: A novel assay was used to determine FIXa activity in plasma samples from volunteer blood donors...
November 2, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29094617/effects-of-barium-chloride-adsorbed-to-polyethylene-glycol-peg-microspheres-on-co-culture-of-human-blood-mononuclear-cell-and-breast-cancer-cell-lines-mcf-7
#7
Fabiana Helen da Silva, Aliny Aparecida Lopes Ribeiro, Alessandra Lima Deluque, Aron Carlos de Melo Cotrim, Patrícia Gelli Feres de Marchi, Eduardo Luzía França, Adenilda Cristina Honorio-França
This study investigated the effects of BaCl2 adsorbed to polyethylene glycol (PEG) microspheres on human blood mononuclear cells (MN) co-cultured with breast cancer cell lines (MCF-7). The MCF-7 cells were obtained from the American Type Culture Collection and the blood mononuclear (MN) cells from volunteer donors. MN cells, MCF-7 cells and their co-culture (MN and MCF-7 cells) were pre-incubated for 24 h with or without 25 and 1000 pg L(-1) BaCl2 (Ba25 and Ba1000), PEG microspheres or 25 and 1000 pg L(-1) BaCl2 adsorbed to PEG microspheres (PEG-Ba25 and PEG-Ba1000)...
November 2, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29079593/hypoxia-modulates-the-purine-salvage-pathway-and-decreases-red-blood-cell-and-supernatant-levels-of-hypoxanthine-during-refrigerated-storage
#8
Travis Nemkov, Kaiqi Sun, Julie A Reisz, Anren Song, Tatsuro Yoshida, Andrew Dunham, Matthew J Wither, Richard O Francis, Robert C Roach, Monika Dzieciatkowska, Stephen C Rogers, Allan Doctor, Anastasios Kriebardis, Marianna Antonelou, Issidora Papassideri, Carolyn Young, Tiffany Thomas, Kirk C Hansen, Steven L Spitalnik, Yang Xia, James C Zimring, Eldad A Hod, Angelo D'Alessandro
Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and, most importantly, hydrogen peroxide. However, it is unclear whether accumulation of intracellular and supernatant hypoxanthine in stored RBC units is clinically relevant for transfused recipients. Leukoreduced RBCs from G6PD-normal or -deficient human volunteers were stored in AS-3 under normoxic, hyperoxic, or hypoxic conditions (with SO2 ranging from <3 to >95%). RBCs from healthy human volunteers were also collected at sea level or after 1-7 days at high altitude (>5000m)...
October 27, 2017: Haematologica
https://www.readbyqxmd.com/read/29078765/strain-dependent-interactions-of-streptococcus-gallolyticus-subsp-gallolyticus-with-human-blood-cells
#9
Imke Grimm, Melanie Weinstock, Ingvild Birschmann, Jens Dreier, Cornelius Knabbe, Tanja Vollmer
BACKGROUND: Streptococcus gallolyticus subsp. gallolyticus (S. gallolyticus) is the causative pathogen in up to 20% of streptococcal-induced infective endocarditis (IE) cases. However, the underlying mechanisms of pathogenesis in S. gallolyticus have not yet been solved. Pathogens causing IE need to employ virulent strategies to initiate and establish infections, such as escape the bloodstream, invade the host-cell, and persist intracellularly. In this study, we examined the induction of inflammation by different S...
October 27, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29053932/the-patterns-of-in-vitro-cell-death-and-inflammatory-cytokines-induced-by-distinct-bcg-vaccine-strains-are-differentially-induced-in-human-mononuclear-cells
#10
C Ponte, M Hacker, M Moraes, L Castello-Branco, F Silva, P Antas
Tuberculosis (TB) remains among the world's leading cause of mortality. For its control, studies of TB vaccines are needed. Since live-attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only TB vaccine currently in use, studies on the protective role of BCG are required. In this study, we analyzed host cells purified directly from whole blood of human immunodeficiency virus (HIV)-negative volunteers, comprising adult healthy donors (HD) and neonates (umbilical cord bloods, UCB), with the aim to directly compare in vitro immune responses with distinct BCG strains in human mononuclear cells...
October 20, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29039348/the-impact-of-agonists-and-antagonists-of-tlr3-and-tlr9-on-concentrations-of-il-6-il10-and-sil-2r-in-culture-supernatants-of-peripheral-blood-mononuclear-cells-derived-from-patients-with-systemic-lupus-erythematosus
#11
Agnieszka Klonowska-Szymczyk, Liliana Kulczycka-Siennicka, Tadeusz Robak, Piotr Smolewski, Barbara Cebula-Obrzut, Ewa Robak
Toll-like receptors (TLR), especially TLR3, 7 and 9, play an important role in the pathogenesis of systemic lupus erythematosus (SLE). In our study blood was collected from 16 patients with SLE and from 8 healthy volunteers. Concentrations of IL-6, IL-10 and sIL-2R were measured by ELISA in mononuclear cell culture supernatant after 24 hours of stimulation by agonists and antagonists of TLR3 and 9 (for TLR3-poli I/C, resveratrol and for TLR9-ODN2006, IRS 945). Stimulation of TLR9 by ODN2006 led to an increase of IL-6 concentration in cell culture supernatants from the cells of healthy volunteers compared with unstimulated cells from controls...
October 13, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29039102/analysis-of-pro-inflammatory-cytokine-and-type-ii-interferon-induction-by-nanoparticles
#12
Timothy M Potter, Barry W Neun, Jamie C Rodriguez, Anna N Ilinskaya, Marina A Dobrovolskaia
Cytokines, chemokines, and interferons are released by the immune cells in response to cellular stress, damage and/or pathogens, and are widely used as biomarkers of inflammation. Certain levels of cytokines are needed to stimulate an immune response in applications such as vaccines or immunotherapy where immune stimulation is desired. However, undesirable elevation of cytokine levels, as may occur in response to a drug or a device, may lead to severe side effects such as systemic inflammatory response syndrome or cytokine storm...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29036415/transfusion-transmissible-infections-among-walk-in-blood-donors-at-kisumu-regional-blood-transfusion-centre-kisumu-county-kenya-2015
#13
Dominic Wamamba, Dickens Onyango, Elvis Oyugi, Evalyne Kanyina, Mark Obonyo, Jane Githuku, James Ransom
Background: Transfusion transmissible infections (TTIs) are threats to blood safety. This study investigated TTIs among volunteer blood donors at the Kisumu Regional Blood Transfusion Centre (KRBTC) in Kenya. Methods: We performed a retrospective record review of blood donor registers at KRBTC, 2015. Walk-in donors accepted for donation were analyzed to determine prevalence of human immunodeficiency virus (HIV), hepatitis B (HBV), hepatitis C (HCV), and syphilis...
November 8, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29029634/is-mmtv-associated-with-human-breast-cancer-maybe-but-probably-not
#14
Raisa Perzova, Lynn Abbott, Patricia Benz, Steve Landas, Seema Khan, Jordan Glaser, Coleen K Cunningham, Bernard Poiesz
BACKGROUND: Conflicting results regarding the association of MMTV with human breast cancer have been reported. Published sequence data have indicated unique MMTV strains in some human samples. However, concerns regarding contamination as a cause of false positive results have persisted. METHODS: We performed PCR assays for MMTV on human breast cancer cell lines and fresh frozen and formalin fixed normal and malignant human breast epithelial samples. Assays were also performed on peripheral blood mononuclear cells from volunteer blood donors and subjects at risk for human retroviral infections...
October 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/29028283/implementation-of-buffy-coat-derived-pooled-platelet-concentrates-for-internal-quality-control-of-light-transmission-aggregometry-a-proof-of-concept-study
#15
F Prüller, K Rosskopf, H Mangge, E Mahla, D von Lewinski, E C Weiss, A Riegler, D Enko
BACKGROUND: Standardized commercially available control material for internal quality control (IQC) of light transmission aggregometry (LTA) is still lacking. Moreover, the provision of normal blood donors to provide fresh platelets is difficult in small laboratories, where "volunteers" may be of short supply. OBJECTIVES: To evaluate the implementation of buffy-coat-derived pooled platelet concentrates (PCs) for IQC material of LTA. METHODS: We used buffy-coat-derived pooled PCs from the blood bank as IQC material for LTA...
October 13, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28992132/dna-strand-breaks-in-peripheral-blood-leucocytes-of-polish-blood-donors
#16
Malgorzata M Dobrzynska, Krzysztof A Pachocki, Katarzyna Owczarska
Knowledge about the basal level of DNA damage in leucocytes of healthy control populations is essential before estimation of the effects of exposure to external agents in biomonitoring studies. The aim of this study was to analyse the effects of some lifestyle factors on baseline DNA damage in leucocytes of humans. The material consisted of the peripheral blood from 276 healthy volunteer blood donors. In addition to the standard blood donation questionnaire, they were asked about age, gender, occupation, radiological history, smoking habit, alcohol consumption, medicine use and pet ownership...
September 13, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28969566/herbal-mixture-adsorbed-to-polyethylene-glycol-microspheres-induces-apoptotic-effects-on-breast-cancer-cells
#17
Aliny Aparecida Lopes Ribeiro, Fabiana Helen da Silva, Aron Carlos de Melo Cotrim, Alessandra Lima Deluque, Patrícia Gelli Feres de Marchi, Danny Laura Gomes Fagundes, Claudia de Sousa Pereira, Eduardo Luzía França, Adenilda Cristina Honorio-França
The combination of medicinal plants and polymeric matrices raised the possibility of obtaining new drugs to treat a number of diseases, including cancer. Breast cancer is one of the most frequent diseases among women, but the effective treatments is still a challenge. Thus, this study investigated the effect of herbal mixture adsorbed to PEG microspheres on MCF-7 human breast cancer cells and these cells in co-culture of blood MN cells. The MCF-7 cells and the blood mononuclear [MN] Cells from volunteer donors...
October 2, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28967462/myophosphorylase-pygm-mutations-determined-by-next-generation-sequencing-in-a-cohort-from-turkey-with-mcardle-disease
#18
Güldal Inal-Gültekin, Bahar Toptaş-Hekimoğlu, Zeliha Görmez, Özlem Gelişin, Hacer Durmuş, Bekir Ergüner, Hüseyin Demirci, Mahmut Ş Sağıroğlu, Yeşim Parman, Feza Deymeer, Hülya Yılmaz-Aydoğan, Sadrettin Pençe, Can Ebru Bekircan-Kurt, Ersin Tan, Sevim Erdem-Özdamar, Duran Üstek, Urs Giger, Oğuz Öztürk, Piraye Serdaroğlu-Oflazer
This study aimed to identify PYGM mutations in patients with McArdle disease from Turkey by next generation sequencing (NGS). Genomic DNA was extracted from the blood of the McArdle patients (n = 67) and unrelated healthy volunteers (n = 53). The PYGM gene was sequenced with NGS and the observed mutations were validated by direct Sanger sequencing. A diagnostic algorithm was developed for patients with suspected McArdle disease. A total of 16 deleterious PYGM mutations were identified, of which 5 were novel, including 1 splice-site donor, 1 frame-shift, and 3 non-synonymous variants...
November 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28962103/erythrocyte-sedimentation-rate-and-fibrinogen-concentration-of-whole-blood-influences-the-cellular-composition-of-platelet-rich-plasma-obtained-from-centrifugation-methods
#19
Wenjing Yin, Zhengliang Xu, Jiagen Sheng, Xuetao Xie, Changqing Zhang
Erythrocyte sedimentation rate (ESR), which reflects the sedimentation rate of platelets, leukocytes and erythrocytes in response to centrifugal force, may influence the cellular composition of platelet-rich plasma (PRP) obtained via centrifugation methods. However, no relevant studies have substantiated this. In the present study, blood was collected from 40 healthy volunteers and used to prepare PRP with two plasma-based preparation systems [YinPRP and Plasma Rich in Growth Factor (PRGF) systems] and two buffy coat-based systems (RegenPRP and WEGOPRP systems) in a single-donor model...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28960897/a-uniform-shear-rate-microfluidic-bioreactor-for-real-time-study-of-proplatelet-formation-and-rapidly-released-platelets
#20
Andres F Martinez, Richard D McMahon, Marc Horner, William M Miller
Platelet transfusions, with profound clinical importance in blood clotting and wound healing, are entirely derived from human volunteer donors. Hospitals rely on a steady supply of donations, but these methods are limited by a 5-day shelf life, the potential risk of contamination, and differences in donor/recipient histocompatibility. These challenges invite the opportunity to generate platelets ex vivo. Although much progress has been made in generating large numbers of culture-derived megakaryocytes (Mks, the precursor cells to platelets), stimulating a high percentage of Mks to undergo platelet release remains a major challenge...
September 27, 2017: Biotechnology Progress
keyword
keyword
62799
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"