Colin Rosenau, Sebastian Köhler, Lion M Soons, Kaarin J Anstey, Carol Brayne, Henry Brodaty, Knut Engedal, Francesca R Farina, Mary Ganguli, Gill Livingston, Constantine G Lyketsos, Francesca Mangialasche, Laura E Middleton, Marcel G M Olde Rikkert, Ruth Peters, Perminder S Sachdev, Nikolaos Scarmeas, Geir Salbaek, Martin P J van Boxtel, Kay Deckers
A 2013 systematic review and Delphi consensus study identified 12 modifiable risk and protective factors for dementia, which were subsequently merged into the "LIfestyle for BRAin health" (LIBRA) score. We systematically evaluated whether LIBRA requires revision based on new evidence. To identify modifiable risk and protective factors suitable for dementia risk reduction, we combined an umbrella review of systematic reviews and meta-analyses with a two-round Delphi consensus study. The review of 608 unique primary studies and opinions of 18 experts prioritized six modifiable factors: hearing impairment, social contact, sleep, life course inequalities, atrial fibrillation, and psychological stress...
December 30, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association