keyword
MENU ▼
Read by QxMD icon Read
search

Alzheimer Revision

keyword
https://www.readbyqxmd.com/read/29133284/the-association-of-health-literacy-and-electronic-health-literacy-with-self-efficacy-coping-and-caregiving-perceptions-among-carers-of-people-with-dementia-research-protocol-for-a-descriptive-correlational-study
#1
Areti Efthymiou, Nicos Middleton, Andreas Charalambous, Evridiki Papastavrou
BACKGROUND: In the last decade, electronic health (eHealth) literacy has attracted the attention of the scientific community, as it is associated with the self-management of patients with chronic diseases and the quality and cost of care. It is estimated that 80% of people with chronic diseases are cared for at home by a family member, friend, or relative. Informal carers are susceptible to physical and mental health problems, as well as social and financial hardships. Nevertheless, there seems to be a research gap in terms of carers' needs, skills, and available resources in the age of new technologies, with the vital role of eHealth literacy of the carers remaining unexplored...
November 13, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29130150/predictors-of-adverse-psychological-experiences-surrounding-genome-wide-profiling-for-disease-risk
#2
K M Broady, K E Ormond, E J Topol, N J Schork, Cinnamon S Bloss
This study aimed to identify predictors of adverse psychological experiences among direct-to-consumer (DTC) genomic test consumers. We performed a secondary analysis on data from the Scripps Genomic Health Initiative (SGHI), which studied 2037 individuals tested with commercially available tests yielding personalized risk estimates for 23 common, genetically complex diseases. As part of the original study, the participants completed baseline and follow-up survey measures assessing demographics, personal and family health history, attitudes toward genetic testing, anxiety (State-Trait Anxiety Inventory (STAI)), test-related distress (Impact of Event Scale-Revised (IES-R)), and reactions to receipt of results...
November 13, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/29130020/what-do-we-know-from-clinical-trials-on-exercise-and-alzheimer-s-disease
#3
Yong Shen, Rena Li
Alzheimer's disease (AD) is the most common form of dementia in elderly with major symptoms of a general term for memory loss and other intellectual abilities impairment which are serious enough to interfere with daily life. While there is no treatment can prevent and revise the cognitive function impairment in AD, physical activity becomes a potential beneficial intervention for AD. Multiple evidences suggested that exercise in general plays beneficial roles in improving brain function. Most common mechanisms of exercise-induced enhancement of brain function are including alteration of neurogenesis, neuron plasticity, neuronal signaling and receptors, as well as neuronal networks...
December 2016: Journal of Sport and Health Science
https://www.readbyqxmd.com/read/29106805/innate-immunity-and-neurodegeneration
#4
Larisa I Labzin, Michael T Heneka, Eicke Latz
The innate immune system plays diverse roles in health and disease. It represents the first line of defense against infection and is involved in tissue repair, wound healing, and clearance of apoptotic cells and cellular debris. Excessive or nonresolving innate immune activation can lead to systemic or local inflammatory complications and cause or contribute to the development of inflammatory diseases. In the brain, microglia represent the key innate immune cells, which are involved in brain development, brain maturation, and homeostasis...
November 6, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/29067333/accelerating-drug-development-for-alzheimer-s-disease-through-the-use-of-data-standards
#5
Jon Neville, Steve Kopko, Klaus Romero, Brian Corrigan, Bob Stafford, Elizabeth LeRoy, Steve Broadbent, Martin Cisneroz, Ethan Wilson, Eric Reiman, Hugo Vanderstichele, Stephen P Arnerić, Diane Stephenson
INTRODUCTION: The exceedingly high rate of failed trials in Alzheimer's disease (AD) calls for immediate attention to improve efficiencies and learning from past, ongoing, and future trials. Accurate, highly rigorous standardized data are at the core of meaningful scientific research. Data standards allow for proper integration of clinical data sets and represent the essential foundation for regulatory endorsement of drug development tools. Such tools increase the potential for success and accuracy of trial results...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29032807/a-comparison-of-the-severe-cognitive-impairment-rating-scale-with-the-mini-mental-state-examination-and-delirium-rating-scale-revised-98-for-delirium-a-cross-sectional-study
#6
So-Hyun Ahn, Jin-Hoon Choi, Chae-Sung Im, Tae-Sung Kim, Jeong Lan Kim
BACKGROUND: Cognitive impairment including attention deficits, disorientation, memory impairment, language disturbance, and impaired visuospatial ability are core symptoms of delirium. The Severe Cognitive Impairment Rating Scale (SCIRS) was developed to assess cognition in patients with severe dementia, but may also be useful in elderly people with delirium. OBJECTIVE: We investigated the use of the SCIRS to assess cognition in elderly patients with delirium. METHODS: We recruited 147 participants, aged ≥65 years, referred for psychiatric consultation at a tertiary-care university hospital...
August 5, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29032015/possible-positive-effect-of-the-apoe-%C3%AE%C2%B52-allele-on-cognition-in-early-to-mid-adult-life
#7
Lindsey I Sinclair, Christopher W Pleydell-Pearce, Ian N M Day
BACKGROUND: ε4 allele possession is associated with an increased risk of Alzheimer's disease. Its effects earlier in life are less well understood. Previous studies have reported both detrimental effects and a lack of effect on cognition outside dementia. We used genotype based recall from the ALSPAC study to investigate whether APOE genotype influences cognition in earlier adult life. METHODS: We invited all individuals with the rarer ε22 or ε44 genotypes and equal numbers of those with ε32, ε33 or ε34 APOE genotypes (total n invited = 1936, ages 23-67)...
October 12, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28990871/cultural-adaptation-of-a-dyadic-intervention-for-korean-couples-coping-with-alzheimer-s-disease
#8
Minyoung Kwak, Jung-Hwa Ha, So-Yeon Hwang, Berit Ingersoll-Dayton, Beth Spencer
OBJECTIVES: The Couples Life Story Approach (CLSA) was recently reveloped in the U.S. for older couples dealing with dementia to improve their quality of life. The purpose of this article is to describe how the CLSA was adapted to be culturally appropriate for older Korean couples and to discuss cultural htemes that emerged during the implementation process. METHODS: The intervention was adapted using the Cultural Adaptation Process Model. The revised materials were implemented on 56 Korean couples...
August 16, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28977092/mild-cognitive-impairment-and-progression-to-dementia-of-alzheimer-s-disease
#9
Ana Beatriz Quintes Steiner, Alessandro Ferrari Jacinto, Vânia Ferreira de Sá Mayoral, Sonia Maria Dozzi Brucki, Vanessa de Albuquerque Citero
The increase in life expectancy in the Brazilian population raises questions about the preparation of the public health system in identifying elderly patients with signs of cognitive impairment. Currently, as a consequence of the long duration of preclinical phase of Alzheimer's disease, efforts of early detection have been emphasized. Clinical dementia presents an important impact on the individual's caregivers, family, society and economy. Identifying individuals who already have some cognitive impairment, despite remaining functional, as well as analyzing associated comorbidities, constitutes an opportunity to analyze possibilities for future interventions...
July 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28975188/personality-change-in-the-preclinical-phase-of-alzheimer-disease
#10
Antonio Terracciano, Yang An, Angelina R Sutin, Madhav Thambisetty, Susan M Resnick
Importance: Changes in behavior and personality are 1 criterion for the diagnosis of dementia. It is unclear, however, whether such changes begin before the clinical onset of the disease. Objective: To determine whether increases in neuroticism, declines in conscientiousness, and changes in other personality traits occur before the onset of mild cognitive impairment or dementia. Design, Setting, and Participants: A cohort of 2046 community-dwelling older adults who volunteered to participate in the Baltimore Longitudinal Study of Aging were included...
September 20, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28943198/incidence-of-dementia-in-elderly-latin-americans-results-of-the-maracaibo-aging-study
#11
Gladys E Maestre, Luis J Mena, Jesus D Melgarejo, Daniel C Aguirre-Acevedo, Gloria Pino-Ramírez, Milady Urribarrí, Inara J Chacon, Carlos A Chávez, Luis Falque-Madrid, Ciro A Gaona, Joseph D Terwilliger, Joseph H Lee, Nikolaos Scarmeas
INTRODUCTION: There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. METHODS: The Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) was used to diagnose dementia, which was classified as Alzheimer's disease, vascular dementia, or other. Age- and sex-specific incidence was estimated as the number of new cases of dementia divided by person-years (p-y) of follow-up...
September 21, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28912299/the-test-your-memory-for-mild-cognitive-impairment-tym-mci
#12
Jeremy M Brown, Claire J Lansdall, Julie Wiggins, Kate E Dawson, Kristina Hunter, James B Rowe, Richard A Parker
BACKGROUND: To validate a short cognitive test: the Test Your Memory for Mild Cognitive Impairment (TYM-MCI) in the diagnosis of patients with amnestic mild cognitive impairment or mild Alzheimer's disease (aMCI/AD). METHODS: Two hundred and two patients with mild memory problems were recruited. All had 'passed' the Mini-Mental State Examination (MMSE). Patients completed the TYM-MCI, the Test Your Memory test (TYM), MMSE and revised Addenbrooke's Cognitive Examination (ACE-R), had a neurological examination, clinical diagnostics and multidisciplinary team review...
September 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28901834/association-between-gait-and-dual-task-with-cognitive-domains-in-older-people-with-cognitive-impairment
#13
Juliana Hotta Ansai, Larissa Pires de Andrade, Paulo Giusti Rossi, Mariana Luciano Almeida, Francisco Assis Carvalho Vale, José Rubens Rebelatto
The authors investigated whether impaired gait and dual-task performances are associated with specific cognitive domains among older people with preserved cognition (PC), mild cognitive impairment (MCI), and mild Alzheimer's disease (AD). The sample comprised 40 older adults with PC, 40 with MCI, and 38 with mild AD. The assessment consisted of gait (measured by 10-m walk test and Timed Up and Go Test [TUGT]), dual task (measured by TUGT associated with a cognitive-motor task of calling a phone number), and cognition (domains of the Addenbrooke Cognitive Examination-Revised and Frontal Assessment Battery [FAB])...
September 13, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28899416/alzheimer-s-disease-prevention-from-risk-factors-to-early-intervention
#14
REVIEW
Marta Crous-Bou, Carolina Minguillón, Nina Gramunt, José Luis Molinuevo
Due to the progressive aging of the population, Alzheimer's disease (AD) is becoming a healthcare burden of epidemic proportions for which there is currently no cure. Disappointing results from clinical trials performed in mild-moderate AD dementia combined with clear epidemiological evidence on AD risk factors are contributing to the development of primary prevention initiatives. In addition, the characterization of the long asymptomatic stage of AD is allowing the development of intervention studies and secondary prevention programmes on asymptomatic at-risk individuals, before substantial irreversible neuronal dysfunction and loss have occurred, an approach that emerges as highly relevant...
September 12, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28892572/deconstructing-normal-pressure-hydrocephalus-ventriculomegaly-as-early-sign-of-neurodegeneration
#15
REVIEW
Alberto J Espay, Gustavo A Da Prat, Alok K Dwivedi, Federico Rodriguez-Porcel, Jennifer E Vaughan, Michela Rosso, Johnna L Devoto, Andrew P Duker, Mario Masellis, Charles D Smith, George T Mandybur, Aristide Merola, Anthony E Lang
Idiopathic normal pressure hydrocephalus (NPH) remains both oversuspected on clinical grounds and underconfirmed when based on immediate and sustained response to cerebrospinal fluid diversion. Poor long-term postshunt benefits and findings of neurodegenerative pathology in most patients with adequate follow-up suggest that hydrocephalic disorders appearing in late adulthood may often result from initially unapparent parenchymal abnormalities. We critically review the NPH literature, highlighting the near universal lack of blinding and controls, absence of specific clinical, imaging, or pathological features, and ongoing dependence for diagnostic confirmation on variable cutoffs of gait response to bedside fluid-drainage testing...
October 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28884752/alzheimer-disease-revising-the-risk-of-alzheimer-disease-in-women
#16
Mitesh Patel
No abstract text is available yet for this article.
October 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28869481/alzheimer-s-disease-diagnosis-relies-on-a-twofold-clinical-biological-algorithm-three-memory-clinic-case-reports
#17
Marcel Levy Nogueira, Dalila Samri, Stéphane Epelbaum, Simone Lista, Per Suppa, Lothar Spies, Harald Hampel, Bruno Dubois, Marc Teichmann
The International Working Group recently provided revised criteria of Alzheimer's disease (AD) proposing that the diagnosis of typical amnesic AD should be established by a clinical-biological signature, defined by the phenotype of an "amnesic syndrome of the hippocampal type" (ASHT) combined with positive in vivo evidence of AD pathophysiology in the cerebrospinal fluid (CSF) or on amyloid PET imaging. The application and clinical value of this refined diagnostic algorithm, initially intended for research purposes, is explored in three memory clinic cases presenting with different cognitive profiles including an ASHT, hippocampal atrophy, and CSF AD-biomarker data...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28806917/study-protocol-pragmatic-randomized-control-trial-of-an-internet-based-intervention-my-tools-4-care-for-family-carers
#18
Wendy Duggleby, Jenny Ploeg, Carrie McAiney, Kathryn Fisher, Jenny Swindle, Tracey Chambers, Sunita Ghosh, Shelley Peacock, Maureen Markle-Reid, Jean Triscott, Allison Williams, Dorothy Forbes, Lori Pollard
BACKGROUND: Family carers of older persons with Alzheimer's' disease and related dementia (ADRD) and multiple chronic conditions (MCC) experience significant, complex, and distressing transitions such as changes to their environment, roles and relationships, physical health, and mental health. An online intervention (My Tools 4 Care) was developed for family carers of persons with ADRD and MCC living at home, with the aim of supporting these carers through transitions and increasing their self-efficacy, hope, and health related quality of life (HRQoL)...
August 14, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28793933/can-cognitive-assessment-really-discriminate-early-stages-of-alzheimer-s-and-behavioural-variant-frontotemporal-dementia-at-initial-clinical-presentation
#19
Sophia Reul, Hubertus Lohmann, Heinz Wiendl, Thomas Duning, Andreas Johnen
BACKGROUND: Neuropsychological testing is considered crucial for differential diagnosis of Alzheimer's disease (AD) and behavioural variant frontotemporal dementia (bvFTD). In-depth neuropsychological assessment revealed specific dysfunctions in the two dementia syndromes. However, a significant overlap of cognitive impairments exists in early disease stages. We questioned whether a standard neuropsychological assessment at initial clinical presentation can delineate patients with AD versus bvFTD...
August 9, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28731443/accuracy-of-clinical-diagnosis-of-dementia-with-lewy-bodies-versus-neuropathology
#20
Ragnhild Skogseth, Tibor Hortobágyi, Hogne Soennesyn, Luiza Chwiszczuk, Dominic Ffytche, Arvid Rongve, Clive Ballard, Dag Aarsland
BACKGROUND: The first consensus criteria for dementia with Lewy bodies (DLB) published in 1996 were revised in 2005, partly because the original clinical criteria had suboptimal sensitivity. Few studies have assessed the accuracy of the 2005 criteria applied prospectively in newly diagnosed patients who have been followed longitudinally. OBJECTIVE: To explore the correlation between clinical and pathological diagnoses in patients with DLB and Parkinson's disease with dementia (PDD)...
2017: Journal of Alzheimer's Disease: JAD
keyword
keyword
62790
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"