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Alzheimer Revision

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https://www.readbyqxmd.com/read/29776894/amyloid-pet-in-neurodegenerative-diseases-with-dementia
#1
V Camacho, A Gómez-Grande, P Sopena, D García-Solís, M Gómez Río, C Lorenzo, S Rubí, J Arbizu
Alzheimer's disease (AD) is a neurodegenerative condition characterized by progressive cognitive decline and memory loss, and is the most common form of dementia. Amyloid plaques with neurofibrillary tangles are a neuropathological hallmark of AD that produces synaptic dysfunction and culminates later in neuronal loss. Amyloid PET is a useful, available and non-invasive technique that provides in vivo information about the cortical amyloid burden. In the latest revised criteria for the diagnosis of AD biomarkers were defined and integrated: pathological and diagnostic biomarkers (increased retention on fibrillar amyloid PET or decreased Aβ1-42 and increased T-Tau or P-Tau in CSF) and neurodegeneration or topographical biomarkers (temporoparietal hypometabolism on 18 F-FDG PET and temporal atrophy on MRI)...
May 15, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29716643/tdp-43-pathology-in-anterior-temporal-pole-cortex-in-aging-and-alzheimer-s-disease
#2
Sukriti Nag, Lei Yu, Patricia A Boyle, Sue E Leurgans, David A Bennett, Julie A Schneider
TDP-43 pathology was investigated in the anterior temporal pole cortex (ATPC) and orbital frontal cortex (OFC), regions often degenerated in frontotemporal lobar degenerations (FTLD), in aging and Alzheimer's disease (AD). Diagnosis of dementia in the 1160 autopsied participants from 3 studies of community-dwelling elders was based on clinical evaluation and cognitive performance tests which were used to create summary measures of the five cognitive domains. Neuronal and glial TDP-43 cytoplasmic inclusions were quantitated in 8 brain regions by immunohistochemistry, and used in ANOVA and regression analyses...
May 1, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29689726/differentiating-between-alzheimer-s-disease-and-vascular-cognitive-impairment-is-the-memory-versus-executive-function-contrast-still-relevant
#3
Daniela Andriuta, Martine Roussel, Mélanie Barbay, Sandrine Despretz-Wannepain, Olivier Godefroy
BACKGROUND: The contrast between memory versus executive function impairments is commonly used to differentiate between neurocognitive disorders (NCDs) due to Alzheimer's disease (AD) and vascular cognitive impairment (VCI). We reconsidered this question because of the current use of AD biomarkers and the recent revision of the criteria for AD, VCI, and dysexecutive syndrome. OBJECTIVE: To establish and compare the neuropsychological profiles in AD (i.e., with positive CSF biomarkers) and in VCI...
April 17, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689725/a-systematic-review-and-aggregated-analysis-on-the-impact-of-amyloid-pet-brain-imaging-on-the-diagnosis-diagnostic-confidence-and-management-of-patients-being-evaluated-for-alzheimer-s-disease
#4
Enrico R Fantoni, Anastasia Chalkidou, John T O' Brien, Gill Farrar, Alexander Hammers
BACKGROUND: Amyloid PET (aPET) imaging could improve patient outcomes in clinical practice, but the extent of impact needs quantification. OBJECTIVE: To provide an aggregated quantitative analysis of the value added by aPET in cognitively impaired subjects. METHODS: Systematic literature searches were performed in Embase and Medline until January 2017. 1,531 cases over 12 studies were included (1,142 cases over seven studies in the primary analysis where aPET was the key biomarker; the remaining cases included as defined groups in the secondary analysis)...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29682230/cognitive-functional-and-physical-activity-impairment-in-elderly-with-alzheimer-s-disease
#5
Renata Valle Pedroso, Danilla Icassatti Corazza, Carla Andreza de Almeida Andreatto, Thays Martins Vital da Silva, José Luiz Riani Costa, Ruth Ferreira Santos-Galduróz
Alzheimer's Disease (AD) is a progressive degenerative disorder that negatively affects quality of life of patients and family members. Objective: The aim of this study is to compare the cognition, level of physical activity and functioning of elderly individuals with mild AD and those without dementia. Methods: The study comprised 24 elderly with mild AD (mean age = 76.9 ± 5.3 years) and 30 elderly without dementia (mean age = 74.1 ± 5.6 years). The following instruments were applied to evaluate cognitive functions: MMSE; Frontal Assessment Battery; Clock Drawing Test; Corsi Blocks, and Verbal Paired Associates...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29656245/individual-differences-in-socioemotional-sensitivity-are-an-index-of-salience-network-function
#6
Gianina Toller, Jesse Brown, Marc Sollberger, Suzanne M Shdo, Laura Bouvet, Paul Sukhanov, William W Seeley, Bruce L Miller, Katherine P Rankin
Connectivity in intrinsically connected networks (ICNs) may predict individual differences in cognition and behavior. The drastic alterations in socioemotional awareness of patients with behavioral variant frontotemporal dementia (bvFTD) are presumed to arise from changes in one such ICN, the salience network (SN). We examined how individual differences in SN connectivity are reflected in overt social behavior in healthy individuals and patients, both to provide neuroscientific insight into this key brain-behavior relationship, and to provide a practical tool to diagnose patients with early bvFTD...
February 27, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29629495/lewy-body-disease-clinical-and-pathological-overlap-syndrome-between-synucleinopathies-parkinson-disease-and-tauopathies-alzheimer-disease
#7
REVIEW
Clovis Foguem, Patrick Manckoundia
Lewy body disease (LBD) is a neurodegenerative disease resulting in dementia. It shares clinical and pathological features with Parkinson disease (PD), the most frequent synucleinopathy, Parkinson disease dementia (PDD), and Alzheimer disease (AD), a tauopathy. Even though the diagnostic criteria for these neurodegenerative diseases are clearly established, and recently revised for LBD, their precise clinical diagnosis is often difficult because LBD, PD, PDD, and AD share epidemiological, clinical, and pathological characteristics...
April 8, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29601083/analysis-of-episodes-of-care-in-medicare-beneficiaries-newly-diagnosed-with-alzheimer-s-disease
#8
Rezaul K Khandker, Christopher M Black, Lin Xie, M Furaha Kariburyo, Baishali M Ambegaonkar, Onur Baser, Huseyin Yuce, Howard Fillit
OBJECTIVES: To study transitions between healthcare settings and quantify the cost burdens associated with different combinations of transitions during a 6-month period before initial Alzheimer's disease (AD) diagnosis so as to investigate how using an episode-of-care approach to payment for specific disease states might apply in AD. DESIGN: A retrospective observational cohort study. SETTING: United States. PARTICIPANTS: A random sample of 8,995 individuals aged 65 to 100 with a diagnosis of AD (International Classification of Diseases, Ninth Revision, Clinical Modification code 331...
March 30, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29587223/hallmarks-of-alzheimer-disease-are-evolving-relentlessly-in-metropolitan-mexico-city-infants-children-and-young-adults-apoe4-carriers-have-higher-suicide-risk-and-higher-odds-of-reaching-nft-stage-v-at-%C3%A2-40-years-of-age
#9
Lilian Calderón-Garcidueñas, Angélica Gónzalez-Maciel, Rafael Reynoso-Robles, Ricardo Delgado-Chávez, Partha S Mukherjee, Randy J Kulesza, Ricardo Torres-Jardón, José Ávila-Ramírez, Rodolfo Villarreal-Ríos
Exposures to fine particulate matter (PM2.5 ) and ozone (O3 ) above USEPA standards are associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) residents have life time exposures to PM2.5 and O3 above USEPA standards. We investigated AD intra and extracellular protein aggregates and ultrastructural neurovascular pathology in 203 MMC residents age 25.36 ± 9.23 y. Immunohistochemical methods were used to identify AT8 hyperphosphorilated tau (Htau) and 4G8 (amyloid β 17-24). Primary outcomes: staging of Htau and amyloid, per decade and cumulative PM2...
July 2018: Environmental Research
https://www.readbyqxmd.com/read/29531518/detection-of-maltreatment-of-people-with-dementia-in-spain-usefulness-of-the-caregiver-abuse-screen-case
#10
Jesús Rivera-Navarro, Rosa Sepúlveda, Israel Contador, Bernardino Fernández-Calvo, Francisco Ramos, Miguel Ángel Tola-Arribas, Miguel Goñi
The objective of our study is to validate the Caregiver Abuse Screen (CASE) as an instrument for detecting the maltreatment of people with dementia in Spain. In total, 326 informal caregivers of people with different types of dementia were interviewed in several cities in northwest Spain. The caregivers were selected from outpatient neurology clinics and associations of relatives of people with Alzheimer's disease and other dementias. A comprehensive sociodemographic questionnaire was administered to all participants, and several standardized scales were used to assess burden, anxiety, depression, social support and resilience...
March 2018: European Journal of Ageing
https://www.readbyqxmd.com/read/29519961/-practice-guideline-for-dementia-2017-critical-point-of-revision
#11
Hidekazu Tomimoto, Kenji Nakashima
A revised version of guideline for dementia has been published in 2017 by the guideline committee under the supervision of Japanese Society of Neurology. This guideline was elaborated for 3 years, and introduces recent understanding of Alzheimer's pathoetiology and major diagnostic guidelines on dementia, being reported later than 2010. Furthermore, this guideline covers new diagnostic tests for dementia, therapeutic algorism for the use of anti-dementia drugs, and full description on the medical resource and social system for dementia care...
March 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29515618/verbal-or-visual-memory-score-and-regional-cerebral-blood-flow-in-alzheimer-disease
#12
Satoshi Hayashi, Seishi Terada, Etsuko Oshima, Shuhei Sato, Kairi Kurisu, Shintaro Takenoshita, Osamu Yokota, Norihito Yamada
Objective: Among many cognitive function deficits, memory impairment is an initial and cardinal symptom in Alzheimer disease (AD). In most cases, verbal and visual memory scores correlate highly, but in some cases the deficit of verbal or visual memory is very different from that of the other memory. In this study, we examined the neural substrates of verbal and visual memory in patients with AD. Methods: One hundred eighty-eight consecutive patients with AD were recruited from outpatient units...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29490200/chemical-kinetics-for-bridging-molecular-mechanisms-and-macroscopic-measurements-of-amyloid-fibril-formation
#13
Thomas C T Michaels, Anđela Šarić, Johnny Habchi, Sean Chia, Georg Meisl, Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles
Understanding how normally soluble peptides and proteins aggregate to form amyloid fibrils is central to many areas of modern biomolecular science, ranging from the development of functional biomaterials to the design of rational therapeutic strategies against increasingly prevalent medical conditions such as Alzheimer's and Parkinson's diseases. As such, there is a great need to develop models to mechanistically describe how amyloid fibrils are formed from precursor peptides and proteins. Here we review and discuss how ideas and concepts from chemical reaction kinetics can help to achieve this objective...
April 20, 2018: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/29475810/contribution-of-alcohol-use-disorders-to-the-burden-of-dementia-in-france-2008-13-a-nationwide-retrospective-cohort-study
#14
Michaël Schwarzinger, Bruce G Pollock, Omer S M Hasan, Carole Dufouil, Jürgen Rehm
BACKGROUND: Dementia is a prevalent condition, affecting 5-7% of people aged 60 years and older, and a leading cause of disability in people aged 60 years and older globally. We aimed to examine the association between alcohol use disorders and dementia risk, with an emphasis on early-onset dementia (<65 years). METHODS: We analysed a nationwide retrospective cohort of all adult (≥20 years) patients admitted to hospital in metropolitan France between 2008 and 2013...
March 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29441654/effect-of-rivastigmine-on-plasma-butyrylcholine-esterase-activity-and-plasma-ghrelin-levels-in-patients-with-dementia-in-alzheimer-s-disease
#15
Atsushi Kuroda, Manabu Setoguchi, Yasushi Uchino, Kazuya Nagata, Daisuke Hokonohara
AIM: Alzheimer's disease causes loss of appetite, resulting in bodyweight reduction. This, in turn, causes progression of cognitive dysfunction and physical complications that hasten death. Earlier care for loss of appetite is essential in Alzheimer's disease management. Rivastigmine is a therapeutic agent for Alzheimer's disease that has dual inhibition effects on acetylcholine esterase and butyrylcholine esterase. Butyrylcholine esterase is known to degrade the gastric hormone, ghrelin, which regulates appetite; therefore, we considered that rivastigmine might have an effect on appetite...
February 14, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29361072/long-term-care-workforce-issues-practice-principles-for-quality-dementia-care
#16
Susan D Gilster, Marie Boltz, Jennifer L Dalessandro
Purpose: This article is one in a series of articles in this supplement addressing best practice for quality dementia care. The Alzheimer's Association, in revising their Dementia Care Practice Recommendations for 2017 has identified staff across the long-term care spectrum as a distinct and important determinant of quality dementia care. The purpose of this article is to highlight areas for developing and supporting a dementia-capable workforce. Methods: The Alzheimer's Association Principles For Advocacy To Assure Quality Dementia Care Across Settings provide a framework to examine interventions to support the dementia care workforce in long-term care settings...
January 18, 2018: Gerontologist
https://www.readbyqxmd.com/read/29350557/omega-3-polyunsaturated-fatty-acids-and-their-health-benefits
#17
Fereidoon Shahidi, Priyatharini Ambigaipalan
Omega-3 polyunsaturated fatty acids (PUFAs) include α-linolenic acid (ALA; 18:3 ω-3), stearidonic acid (SDA; 18:4 ω-3), eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3). In the past few decades, many epidemiological studies have been conducted on the myriad health benefits of omega-3 PUFAs. In this review, we summarized the structural features, properties, dietary sources, metabolism, and bioavailability of omega-3 PUFAs and their effects on cardiovascular disease, diabetes, cancer, Alzheimer's disease, dementia, depression, visual and neurological development, and maternal and child health...
March 25, 2018: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/29346523/timed-up-and-go-test-and-future-dementia-occurrence
#18
Ji Eun Lee, Dong Wook Shin, Su-Min Jeong, Ki Young Son, Belong Cho, Jong Lull Yoon, Byung Joo Park, In Soon Kwon, Jinkook Lee, SangYun Kim
Background: This study evaluated whether baseline results of the Timed Up and Go (TUG) test is associated with future dementia occurrence. Methods: Using the Korean National Health Insurance Service-National Health Screening Cohort database, we identified 49 283 subjects without a dementia diagnosis who participated in the National Screening Program for Transitional Ages at 66 years of age during 2007-2012. Gait impairment was defined as taking longer than 10 seconds to perform the TUG test...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29341070/personality-changes-during-the-transition-from-cognitive-health-to-mild-cognitive-impairment
#19
Richard J Caselli, Blake T Langlais, Amylou C Dueck, Bruce R Henslin, Travis A Johnson, Bryan K Woodruff, Charlene Hoffman-Snyder, Dona E C Locke
BACKGROUND/OBJECTIVES: Behavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether personality changes that predispose to behavioral disorders arise during the transition from preclinical AD to mild cognitive impairment (MCI). DESIGN: Longitudinal observational cohort study...
January 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29261338/caenorhabditis-elegans-a-convenient-in-vivo-model-for-assessing-the-impact-of-food-bioactive-compounds-on-obesity-aging-and-alzheimer-s-disease
#20
Peiyi Shen, Yiren Yue, Jolene Zheng, Yeonhwa Park
Caenorhabditis elegans is a small free-living nematode that lives in temperate soil environments. It has been widely employed as an animal model in research involving obesity, aging, and neurodegenerative diseases, including Alzheimer's disease, because of its various advantages, such as small size, large number of progeny, completely sequenced genome, and short life span, over traditional animal models of vertebrates. These benefits contribute to an ideal research model organism. In this review, we provide an introduction to C...
March 25, 2018: Annual Review of Food Science and Technology
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