keyword
MENU ▼
Read by QxMD icon Read
search

Alzheimer Revision

keyword
https://www.readbyqxmd.com/read/27858710/app-mutations-in-cerebral-amyloid-angiopathy-with-or-without-cortical-calcifications-report-of-three-families-and-a%C3%A2-literature-review
#1
François Sellal, David Wallon, Laurent Martinez-Almoyna, Cecilia Marelli, Abhinav Dhar, Héléne Oesterlé, Anne Rovelet-Lecrux, Stéphane Rousseau, Christina E Kourkoulis, Jon Rosand, Zora Y DiPucchio, Matthew Frosch, Claudine Gombert, Bertrand Audoin, Manuéle Mine, Florence Riant, Thierry Frebourg, Didier Hannequin, Dominique Campion, Steven M Greenberg, Elisabeth Tournier-Lasserve, Gaël Nicolas
BACKGROUND: Specific APP mutations cause cerebral amyloid angiopathy (CAA) with or without Alzheimer's disease (AD). OBJECTIVE: We aimed at reporting APP mutations associated with CAA, describe the clinical, cerebrospinal fluid AD biomarkers, and neuroimaging features, and compare them with the data from the literature. METHODS: We performed a retrospective study in two French genetics laboratories by gathering all clinical and neuroimaging data from patients referred for a genetic diagnosis of CAA with an age of onset before 66 years and fulfilling the other Boston revised criteria...
November 14, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27847684/longitudinal-change-in-everyday-function-and-behavioral-symptoms-in-frontotemporal-dementia
#2
Claire M O'Connor, Lindy Clemson, Michael Hornberger, Cristian E Leyton, John R Hodges, Olivier Piguet, Eneida Mioshi
BACKGROUND: The relationship between behavioral changes and functional decline in frontotemporal dementia (FTD) is not well understood. METHODS: Thirty-nine patients (21 behavioral variant FTD [bvFTD], 18 semantic variant primary progressive aphasia [svPPA]) were followed up longitudinally (2-4 years follow-up). Functional (Disability Assessment for Dementia) and behavioral (Cambridge Behavioural Inventory Revised) assessments were included for between-group (pairwise comparisons, mixed model analysis) and within-group analyses (bivariate correlations)...
October 2016: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/27834781/do-cancer-drugs-counteract-neurodegeneration-repurposing-for%C3%A2-alzheimer-s-disease
#3
Fiammetta Monacelli, Michele Cea, Roberta Borghi, Patrizio Odetti, Alessio Nencioni
In spite of in depth investigations in the field of the amyloid cascade hypothesis, so far, no disease modifying therapy has been developed for Alzheimer's disease (AD). The pathophysiology provides some evidence of the inverse correlation between cancer and AD. Both AD and cancer are characterized by abnormal cellular behaviors; trigger factors along with a meta synchronously action is expected to drive cancer or neurodegeneration, supporting, respectively, progressive neuronal loss or uncontrolled cell proliferation in cancer cells...
November 7, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27802233/multimodal-cognitive-enhancement-therapy-for-patients-with-mild-cognitive-impairment-and-mild-dementia-a%C3%A2-multi-center-randomized-controlled-double-blind-crossover-trial
#4
Ji Won Han, Hyeonggon Lee, Jong Woo Hong, Kayoung Kim, Taehyun Kim, Hye Jin Byun, Ji Won Ko, Jong Chul Yoon, Seung-Ho Ryu, Nam-Jin Lee, Chi-Un Pae, Ki Woong Kim
We developed and evaluated the effect of Multimodal Cognitive Enhancement Therapy (MCET) consisting of cognitive training, cognitive stimulations, reality orientation, physical therapy, reminiscence therapy, and music therapy in combination in older people with mild cognitive impairment (MCI) or mild dementia. This study was a multi-center, double-blind, randomized, placebo-controlled, two-period cross-over study (two 8-week treatment phases separated by a 4-week wash-out period). Sixty-four participants with MCI or dementia whose Clinical Dementia Rating was 0...
October 11, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27785004/psen1-l226f-mutation-in-a-patient-with-early-onset-alzheimer-s-disease-in-korea
#5
Eva Bagyinszky, Sun Ah Park, Hyung Jun Kim, Seong Hye Choi, Seong Soo A An, Sang Yun Kim
In this study, we report a first 226leucine (Leu) mutation to phenylalanine (Phe) in (PSEN1, CTC>TTC, L226F) in Asia from a Korean early-onset Alzheimer's disease (EOAD) patient. Polymerase chain reaction (PCR)-single strand conformation polymorphism, sequencing, and in silico predictions were performed. Previously, L226F was reported in EOAD patients by Zekanowski et al and Gómez-Tortosa et al. Disease phenotypes appeared in their thirties, and family history was positive in both cases. In our patient, age of onset was similar (37 years of age), but the mutation seemed to be de novo, since no affected family member was found...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27770234/soluble-pre-fibrillar-tau-and-%C3%AE-amyloid-species-emerge-in-early-human-alzheimer-s-disease-and-track-disease-progression-and-cognitive-decline
#6
David J Koss, Glynn Jones, Anna Cranston, Heidi Gardner, Nicholas M Kanaan, Bettina Platt
Post-mortem investigations of human Alzheimer's disease (AD) have largely failed to provide unequivocal evidence in support of the original amyloid cascade hypothesis, which postulated deposition of β-amyloid (Aβ) aggregates to be the cause of a demented state as well as inductive to tau neurofibrillary tangles (NFTs). Conflicting evidence suggests, however, that Aβ plaques and NFTs, albeit to a lesser extent, are present in a substantial subset of non-demented individuals. Hence, a range of soluble tau and Aβ species has more recently been implicated as the disease-relevant toxic entities...
December 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27732893/two-cholinesterase-inhibitors-trigger-dissimilar-effects-on-behavior-and-body-weight-in-c57bl-6-mice-the-case-of-chlorpyrifos-and-rivastigmine
#7
Pia Basaure, Fiona Peris-Sampedro, Maria Cabré, Ingrid Reverte, Maria Teresa Colomina
Cholinesterases (ChE) are common targets of organophosphate (OP) pesticides and play a critical role in the pathology of some dementias. While chlorpyrifos (CPF) remains one of the most commonly used OPs in the world, numerous investigations have reported its neurotoxic potential and highlighted behavioral disturbances upon its administration. Rivastigmine currently serves to treat Alzheimer's disease, but it may induce cholinergic overstimulation in non-demented individuals. The present investigation aimed to compare the acute and delayed effects caused by both ChE inhibitors in adult C57BL/6 male mice...
October 11, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27693131/timed-up-and-go-test-atrophy-of-medial-temporal-areas-and-cognitive-functions-in-community-dwelling-older-adults-with-normal-cognition-and-mild-cognitive-impairment
#8
Yujiro Kose, Masahiro Ikenaga, Yosuke Yamada, Kazuhiro Morimura, Noriko Takeda, Shinji Ouma, Yoshio Tsuboi, Tatsuo Yamada, Misaka Kimura, Akira Kiyonaga, Yasuki Higaki, Hiroaki Tanaka
AIM: This study aimed to ascertain if performance on the Timed Up and Go (TUG) test is associated with indicators of brain volume and cognitive functions among community-dwelling older adults with normal cognition or mild cognitive impairment. METHODS: Participants were 80 community-dwelling older adults aged 65-89years (44 men, 36 women), including 20 with mild cognitive impairment. Participants completed the TUG and a battery of cognitive assessments, including the Mini-Mental State Examination (MMSE), the Logical Memory I and II (LM-I, LM-II) subtests of the Wechsler Memory Scale-Revised; and the Trail Making Test A and B (TMT-A, TMT-B)...
September 28, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27687251/fully-automated-structural-mri-of-the-brain-in-clinical-dementia-workup
#9
Karin Persson, Geir Selbæk, Anne Brækhus, Mona Beyer, Maria Barca, Knut Engedal
BACKGROUND: The dementia syndrome has been regarded a clinical diagnosis but the focus on supplemental biomarkers is increasing. An automatic magnetic resonance imaging (MRI) volumetry method, NeuroQuant® (NQ), has been developed for use in clinical settings. PURPOSE: To evaluate the clinical usefulness of NQ in distinguishing Alzheimer's disease dementia (AD) from non-dementia and non-AD dementia. MATERIAL AND METHODS: NQ was performed in 275 patients diagnosed according to the criteria of ICD-10 for AD, vascular dementia and Parkinson's disease dementia (PDD); the Winblad criteria for mild cognitive impairment; the Lund-Manchester criteria for frontotemporal dementia; and the revised consensus criteria for Lewy body dementia (LBD)...
September 28, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27686019/neprilysin-inhibitors-emerging-therapy-for-heart-failure
#10
Anjali Tiku Owens, Susan Brozena, Mariell Jessup
Biologically active natriuretic peptides (NPs) are an integral part of cardiac homeostasis as they help to maintain sodium and fluid balance. When homeostasis is perturbed by neurohormonal activation in heart failure, levels of NPs rise in response. Neprilysin (NEP) is a naturally occuring enzyme that breaks down NPs. Scientists have recently discovered a novel pharmacologic agent that combines a NEP inhibitor and an angiotensin receptor blocker. In a large clinical trial, this new drug was found to reduce hospitalization and mortality in systolic heart failure...
September 21, 2016: Annual Review of Medicine
https://www.readbyqxmd.com/read/27620855/motivating-mature-adults-to-be-physically-active
#11
Jennifer L Etnier, William B Karper, Se-Yun Park, Chia-Hao Shih, Aaron T Piepmeier, Laurie Wideman
As a population, middle-aged and older adults are not meeting national guidelines for exercise. The purpose of this study was to describe factors associated with exercise adherence in an 8-month program offered as part of a research study testing the effects of exercise on cognitive performance for persons with a family history of Alzheimer's disease (AD). After completion of the program, participants provided open-ended responses indicating their reasons for adhering to the exercise program, and they completed the Motives for Physical Activities Measure-Revised...
September 6, 2016: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/27598537/lesion-topography-and-microscopic-white-matter-tract-damage-contribute-to-cognitive-impairment-in-symptomatic-carotid-artery-disease
#12
Dewen Meng, Akram A Hosseini, Richard J Simpson, Quratulain Shaikh, Christopher R Tench, Robert A Dineen, Dorothee P Auer
Purpose To investigate associations between neuroimaging markers of cerebrovascular disease, including lesion topography and extent and severity of strategic and global cerebral tissue injury, and cognition in carotid artery disease (CAD). Materials and Methods All participants gave written informed consent to undergo brain magnetic resonance imaging and the Addenbrooke's Cognitive Examination-Revised. One hundred eight patients with symptomatic CAD but no dementia were included, and a score less than 82 represented cognitive impairment...
September 6, 2016: Radiology
https://www.readbyqxmd.com/read/27589525/disrupted-brain-network-in-progressive-mild-cognitive-impairment-measured-by-eigenvector-centrality-mapping-is-linked-to-cognition-and-cerebrospinal-fluid-biomarkers
#13
Tiantian Qiu, Xiao Luo, Zhujing Shen, Peiyu Huang, Xiaojun Xu, Jiong Zhou, Minming Zhang
Mild cognitive impairment (MCI) is a heterogeneous condition associated with a high risk of progressing to Alzheimer's disease (AD). Although functional brain network alterations have been observed in progressive MCI (pMCI), the underlying pathological mechanisms of network alterations remain unclear. In the present study, we evaluated neuropsychological, imaging, and cerebrospinal fluid (CSF) data at baseline across a cohort of: 21 pMCI patients, 33 stable MCI (sMCI) patients, and 29 normal controls. Fast eigenvector centrality mapping (fECM) based on resting-state functional MRI (rsfMRI) was used to investigate brain network organization differences among these groups, and we further assessed its relation to cognition and AD-related pathology...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27579672/reference-measurement-procedure-for-csf-amyloid-beta-a%C3%AE-1-42-and-the-csf-a%C3%AE-1-42-a%C3%AE-1-40-ratio-a-cross-validation-study-against-amyloid-pet
#14
Josef Pannee, Erik Portelius, Lennart Minthon, Johan Gobom, Ulf Andreasson, Henrik Zetterberg, Oskar Hansson, Kaj Blennow
A clinical diagnosis of Alzheimer's disease is currently made on the basis of results from cognitive tests in combination with medical history and general clinical evaluation, but the peptide amyloid-beta (Aβ) in cerebrospinal fluid (CSF) is increasingly used as a biomarker for amyloid pathology in clinical trials and in recently proposed revised clinical criteria for Alzheimer's disease. Recent analytical developments have resulted in mass spectrometry (MS) reference measurement procedures for absolute quantification of Aβ1-42 in CSF...
November 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27578455/comprehensive-effects-of-galantamine-and-cilostazol-combination-therapy-on-patients-with-alzheimer-s-disease-with-asymptomatic-lacunar-infarction
#15
Nozomi Hishikawa, Yusuke Fukui, Kota Sato, Yasuyuki Ohta, Toru Yamashita, Koji Abe
AIM: The coexistence of Alzheimer's disease (AD) and cerebrovascular disease pathology increases age-dependently. We comprehensively analyzed the clinical effects of galantamine or cilostazol monotherapy to the add-on combination therapy on three major factors of dementia, such as cognitive, affective and activities of daily living functions in AD patients with asymptomatic lacunar infarction. METHODS: We divided 101 AD patients with asymptomatic lacunar infarction into two subgroups: group A (n = 61, first treated with galantamine and then cilostazol added) and group B (n = 40, first treated with cilostazol and galantamine added)...
August 31, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27567869/so-close-yet-so-far-executive-contribution-to-memory-processing-in-behavioral-variant-frontotemporal-dementia
#16
Maxime Bertoux, Siddharth Ramanan, Andrea Slachevsky, Stephanie Wong, Fernando Henriquez, Gada Musa, Carolina Delgado, Emma Flanagan, Michel Bottlaender, Marie Sarazin, Michael Hornberger, Bruno Dubois
BACKGROUND: Memory impairment in behavioral variant frontotemporal dementia (bvFTD) is traditionally considered to be mild and attributed to prefrontal cortex dysfunction. Recent studies, however, indicated that some patients can present with a memory impairment of the hippocampal type, showing storage and consolidation deficits in addition to the more executive/prefrontal related encoding and strategic difficulties. OBJECTIVE: This study aimed to study the relationship between executive functions (EF) and memory processes in bvFTD via a data-driven approach...
October 4, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27546055/the-choroid-plexus-in-health-and-in-disease-dialogues-into-and-out-of-the-brain
#17
Fernanda Marques, João Carlos Sousa, Alexandra Brito, Jens Pahnke, Cecilia Santos, Margarida Correia-Neves, Joana Almeida Palha
This article brings the choroid plexus into the context of health and disease. It is remarkable that the choroid plexus, composed by the monolayer of epithelial cells that lie in a highly vascularized stroma, floating within the brain ventricles, gets so little attention in major physiology and medicine text books and in the scientific literature in general. Consider that it is responsible for producing most of the about 150mL of cerebrospinal fluid that fills the brain ventricles and the subarachnoid space and surrounds the spinal cord in the adult human brain, which is renewed approximately 2-3 times daily...
August 18, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27535304/revising-the-resistiveness-to-care-scale
#18
Rita A Jablonski-Jaudon, Vicki Winstead, Corteza Jones-Townsend, Andres Azuero, Ellen Mahoney, Ann M Kolanowski
BACKGROUND AND PURPOSE: The Resistiveness to Care Scale for Dementia of the Alzheimer's Type was developed to quantify care-resistant behavior. The purpose of this article is to explain how the instrument was modified and tested in two clinical studies that examined interventions to improve the oral hygiene of persons with dementia who resist care. METHODS: After pilot testing, the revised instrument (RTC-r) was used in 7 facilities (N = 83 residents). Systematic training procedures were implemented to preserve reliability...
2016: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/27513513/-not-available
#19
Marta Baena González, Guillermo Molina Recio
Introducción: la disfagia es un síntoma que se refiere a la dificultad para mover el bolo alimentario desde la boca al estómago. A pesar de su relevancia y de la gravedad de sus posibles complicaciones, es poco conocida y estudiada. La prevalencia de la disfagia orofaríngea en enfermosde alzhéimer es de un 84% y puede originar complicaciones de gran trascendencia clínica como consecuencia de las alteraciones en la eficacia de la deglución, y en la seguridad de la misma.Objetivo: conocer el estado actual del conocimiento en relación al abordaje de la disfagia en enfermos de alzhéimer, localizando aquellos factores que permitan un diagnóstico precoz que facilite la prevención de complicaciones y la elección de la pauta de actuación más adecuada...
June 30, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27490018/metacohorts-for-the-study-of-vascular-disease-and-its-contribution-to-cognitive-decline-and-neurodegeneration-an-initiative-of-the-joint-programme-for-neurodegenerative-disease-research
#20
Martin Dichgans, Joanna Wardlaw, Eric Smith, Vera Zietemann, Sudha Seshadri, Perminder Sachdev, Geert Jan Biessels, Franz Fazekas, Oscar Benavente, Leonardo Pantoni, Frank-Erik De Leeuw, Bo Norrving, Paul Matthews, Christopher Chen, Vincent Mok, Marco Düring, Will Whiteley, Kirsten Shuler, Alvaro Alonso, Sandra E Black, Carol Brayne, Hugues Chabriat, Charlotte Cordonnier, Fergus Doubal, Emrah Duzel, Michael Ewers, Richard Frayne, Vladimir Hachinski, Mohammad Arfan Ikram, Frank Jessen, Eric Jouvent, Jennifer Linn, John O'Brien, Robert van Oostenbrugge, Rainer Malik, Bernard Mazoyer, Reinhold Schmidt, Luciano A Sposato, Blossom Stephan, Richard H Swartz, Meike Vernooij, Anand Viswanathan, David Werring, Koji Abe, Louise Allan, Francesco Arba, H-C Diener, S Davis, G Hankey, K R Lees, B Ovbiagele, C Weir, Hee-Joon Bae, Philip Mw Bath, Regis Bordet, Monique Breteler, Seong Choi, Ian Deary, Charles DeCarli, Klaus Ebmeier, Lei Feng, Steven M Greenberg, Masafumi Ihara, Rajesh Kalaria, SanYun Kim, Jae-Sung Lim, Richard I Lindley, Gillian Mead, Alison Murray, Terry Quinn, Craig Ritchie, Ralph Sacco, Rustam Al-Shahi Salman, Nikola Sprigg, Cathie Sudlow, Alan Thomas, Martin van Boxtel, Jeroen van der Grond, Aad van der Lugt, Yuan-Han Yang
Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically "silent" cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors...
August 1, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
keyword
keyword
62790
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"