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JOURNAL ARTICLE
Thomas J Flotte, Stephanie A Derauf, Rachel K Byrd, Trynda N Kroneman, Debra A Bell, Lucas Stetzik, Seung-Yi Lee, Alireza Samiei, Steven N Hart, Joaquin J Garcia, Gillian Beamer, Thomas Westerling-Bui
CONTEXT.—: Artificial intelligence is a transforming technology for anatomic pathology. Involvement within the workforce will foster support for algorithm development and implementation. OBJECTIVE.—: To develop a supportive ecosystem that enables pathologists with variable expertise in artificial intelligence to create algorithms in a development environment with seamless transition to a production environment. RESULTS.—: The development team considered internal development and vended solutions...
April 23, 2024: Archives of Pathology & Laboratory Medicine
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JOURNAL ARTICLE
Ola A Elgamal, Sydney Fobare, Sandip Vibhute, Abeera Mehmood, Dennis C Vroom, Mariah L Johnson, Blaise Stearns, James R Lerma, Jean Truxall, Emily Stahl, Bridget Carmichael, Shelley J Orwick, Alice S Mims, Emily Curran, Ramasamy Santhanam, Susheela Tridandapani, Mitch A Phelps, Zhiliang Xie, Christopher C Coss, Sharyn D Baker, Jeffrey Patrick, Janel K Ezzell, Jayesh Rai, Jianmin Pan, Shesh N Rai, Cody Stillwell, Mark Wunderlich, Mouad Abdulrahim, Thomas E Goodwin, Gerard Hilinski, Chad E Bennett, Erin Hertlein, John C Byrd
Acute myeloid leukemia (AML) is a fatal disease characterized by the accumulation of undifferentiated myeloblasts, and agents that promote differentiation have been effective in this disease but are not curative. Dihydroorotate dehydrogenase inhibitors (DHODHi) have the ability to promote AML differentiation and target aberrant malignant myelopoiesis. We introduce HOSU-53, a DHODHi with significant monotherapy activity, which is further enhanced when combined with other standard-of-care therapeutics. We further discovered that DHODHi modulated surface expression of CD38 and CD47, prompting the evaluation of HOSU-53 combined with anti-CD38 and anti-CD47 therapies, where we identified a compelling curative potential in an aggressive AML model with CD47 targeting...
April 22, 2024: JCI Insight
#3
JOURNAL ARTICLE
Sydney Fobare, Ola A Elgamal, Mark Wunderlich, Emily Stahl, Abeera Mehmood, Casie Furby, James R Lerma, Thomas M Sesterhenn, Jianmin Pan, Jayesh Rai, Megan E Johnstone, Amina Abdul-Aziz, Mariah L Johnson, Shesh N Rai, John C Byrd, Erin Hertlein
BACKGROUND: Acute myeloid leukemia (AML) is the malignant proliferation of immature myeloid cells characterized by a block in differentiation. As such, novel therapeutic strategies to promote the differentiation of immature myeloid cells have been successful in AML, although these agents are targeted to a specific mutation that is only present in a subset of AML patients. In the current study, we show that targeting the epigenetic modifier enhancer of zeste homolog 2 (EZH2) can induce the differentiation of immature blast cells into a more mature myeloid phenotype and promote survival in AML murine models...
January 29, 2024: Cancers
#4
Blake Warner, Thomas Pranzatelli, Paola Perez, Anson Ku, Bruno Fernandes Matuck, Khoa Huynh, Shunsuke Sakai, Mehdi Abed, Shyh-Ing Jang, Eiko Yamada, Kalie Dominick, Zara Ahmed, Amanda Oliver, Rachael Wasikowski, Quinn Easter, M Teresa Magone, Alan Baer, Eileen Pelayo, Zohreh Khavandgar, Sarthak Gupta, David Kleiner, Christopher Lessard, A Farris, Daniel Martin, Robert Morell, Changyu Zheng, Nicholas Rachmaninoff, Jose Maldonado-Ortiz, Xufeng Qu, Marit Aure, Mohammad Dezfulian, Ross Lake, Sarah Teichmann, Daniel Barber, Lam Tsoi, Adam Sowalsky, Katarzyna Tyc, Johann Gudjonsson, Kevin Byrd, Philip Johnson, Jinze Liu, John Chiorini
Sjögren's Disease (SjD) is a systemic autoimmune disease without a clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health and disease we developed a comprehensive understanding of the cellular landscape of healthy salivary glands and how that landscape changes in SjD patients. We identified novel seromucous acinar cell types and identified a population of PRR4+CST3+WFDC2- seromucous acinar cells that are particularly targeted in SjD...
December 19, 2023: Research Square
#5
JOURNAL ARTICLE
J W Thomas Byrd, Kay S Jones, Sharon Duncan
PURPOSE: The purpose of this study is to report the outcomes of endoscopic repair in a consecutive series of patients with follow-up ranging from five to ten years. METHODS: Sixty-five consecutive hips in 63 patients (2 bilateral) undergoing endoscopic abductor tendon repair with minimum five-year follow-up were assessed with modified Harris Hip Scores (mHHS). The minimal clinically important difference (MCID) was determined as one half the standard deviation of the amount of improvement...
December 11, 2023: Arthroscopy
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JOURNAL ARTICLE
Jared Becksfort, Jinsoo Uh, Andrew Saunders, Julia A Byrd, Hannah M Worrall, Matt Marker, Christian Melendez-Suchi, Yimei Li, Jenghwa Chang, Kavitha Raghavan, Thomas E Merchant, Chia-Ho Hua
This study quantifies setup uncertainty in brain tumor patients who received image-guided proton therapy. Patients analyzed include 165 children, adolescents, and young adults (median age at radiotherapy: 9 years (range: 10 months to 24 years); 80 anesthetized and 85 awake) enrolled in a single-institution prospective study from 2020 to 2023. Cone-beam computed tomography (CBCT) was performed daily to calculate and correct manual setup errors, once per course after setup correction to measure residual errors, and weekly after treatments to assess intrafractional motion...
November 20, 2023: Cancers
#7
JOURNAL ARTICLE
Michael A Gargano, Nicolas Matentzoglu, Ben Coleman, Eunice B Addo-Lartey, Anna V Anagnostopoulos, Joel Anderton, Paul Avillach, Anita M Bagley, Eduard Bakštein, James P Balhoff, Gareth Baynam, Susan M Bello, Michael Berk, Holli Bertram, Somer Bishop, Hannah Blau, David F Bodenstein, Pablo Botas, Kaan Boztug, Jolana Čady, Tiffany J Callahan, Rhiannon Cameron, Seth J Carbon, Francisco Castellanos, J Harry Caufield, Lauren E Chan, Christopher G Chute, Jaime Cruz-Rojo, Noémi Dahan-Oliel, Jon R Davids, Maud de Dieuleveult, Vinicius de Souza, Bert B A de Vries, Esther de Vries, J Raymond DePaulo, Beata Derfalvi, Ferdinand Dhombres, Claudia Diaz-Byrd, Alexander J M Dingemans, Bruno Donadille, Michael Duyzend, Reem Elfeky, Shahim Essaid, Carolina Fabrizzi, Giovanna Fico, Helen V Firth, Yun Freudenberg-Hua, Janice M Fullerton, Davera L Gabriel, Kimberly Gilmour, Jessica Giordano, Fernando S Goes, Rachel Gore Moses, Ian Green, Matthias Griese, Tudor Groza, Weihong Gu, Julia Guthrie, Benjamin Gyori, Ada Hamosh, Marc Hanauer, Kateřina Hanušová, Yongqun Oliver He, Harshad Hegde, Ingo Helbig, Kateřina Holasová, Charles Tapley Hoyt, Shangzhi Huang, Eric Hurwitz, Julius O B Jacobsen, Xiaofeng Jiang, Lisa Joseph, Kamyar Keramatian, Bryan King, Katrin Knoflach, David A Koolen, Megan L Kraus, Carlo Kroll, Maaike Kusters, Markus S Ladewig, David Lagorce, Meng-Chuan Lai, Pablo Lapunzina, Bryan Laraway, David Lewis-Smith, Xiarong Li, Caterina Lucano, Marzieh Majd, Mary L Marazita, Victor Martinez-Glez, Toby H McHenry, Melvin G McInnis, Julie A McMurry, Michaela Mihulová, Caitlin E Millett, Philip B Mitchell, Veronika Moslerová, Kenji Narutomi, Shahrzad Nematollahi, Julian Nevado, Andrew A Nierenberg, Nikola Novák Čajbiková, John I Nurnberger, Soichi Ogishima, Daniel Olson, Abigail Ortiz, Harry Pachajoa, Guiomar Perez de Nanclares, Amy Peters, Tim Putman, Christina K Rapp, Ana Rath, Justin Reese, Lauren Rekerle, Angharad M Roberts, Suzy Roy, Stephan J Sanders, Catharina Schuetz, Eva C Schulte, Thomas G Schulze, Martin Schwarz, Katie Scott, Dominik Seelow, Berthold Seitz, Yiping Shen, Morgan N Similuk, Eric S Simon, Balwinder Singh, Damian Smedley, Cynthia L Smith, Jake T Smolinsky, Sarah Sperry, Elizabeth Stafford, Ray Stefancsik, Robin Steinhaus, Rebecca Strawbridge, Jagadish Chandrabose Sundaramurthi, Polina Talapova, Jair A Tenorio Castano, Pavel Tesner, Rhys H Thomas, Audrey Thurm, Marek Turnovec, Marielle E van Gijn, Nicole A Vasilevsky, Markéta Vlčková, Anita Walden, Kai Wang, Ron Wapner, James S Ware, Addo A Wiafe, Samuel A Wiafe, Lisa D Wiggins, Andrew E Williams, Chen Wu, Margot J Wyrwoll, Hui Xiong, Nefize Yalin, Yasunori Yamamoto, Lakshmi N Yatham, Anastasia K Yocum, Allan H Young, Zafer Yüksel, Peter P Zandi, Andreas Zankl, Ignacio Zarante, Miroslav Zvolský, Sabrina Toro, Leigh C Carmody, Nomi L Harris, Monica C Munoz-Torres, Daniel Danis, Christopher J Mungall, Sebastian Köhler, Melissa A Haendel, Peter N Robinson
The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English...
January 5, 2024: Nucleic Acids Research
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JOURNAL ARTICLE
John Soghigian, Charles Sither, Silvia Andrade Justi, Gen Morinaga, Brian K Cassel, Christopher J Vitek, Todd Livdahl, Siyang Xia, Andrea Gloria-Soria, Jeffrey R Powell, Thomas Zavortink, Christopher M Hardy, Nathan D Burkett-Cadena, Lawrence E Reeves, Richard C Wilkerson, Robert R Dunn, David K Yeates, Maria Anice Sallum, Brian D Byrd, Michelle D Trautwein, Yvonne-Marie Linton, Michael H Reiskind, Brian M Wiegmann
Mosquitoes have profoundly affected human history and continue to threaten human health through the transmission of a diverse array of pathogens. The phylogeny of mosquitoes has remained poorly characterized due to difficulty in taxonomic sampling and limited availability of genomic data beyond the most important vector species. Here, we used phylogenomic analysis of 709 single copy ortholog groups from 256 mosquito species to produce a strongly supported phylogeny that resolves the position of the major disease vector species and the major mosquito lineages...
October 6, 2023: Nature Communications
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JOURNAL ARTICLE
Dallas J Smith, Jeremy A W Gold, Tom Chiller, Nirma D Bustamante, Maria Julia Marinissen, Gabriel Garcia Rodriquez, Vladimir Brian Gonzalez Cortes, Celida Duque Molina, Samantha Williams, Axel A Vazquez Deida, Katrina Byrd, Peter G Pappas, Thomas F Patterson, Nathan P Wiederhold, George R Thompson Iii, Luis Ostrosky-Zeichner
BACKGROUND: Public health officials are responding to an outbreak of fungal meningitis among patients who received procedures under epidural anesthesia at two clinics (River Side Surgical Center and Clinica K-3) in Matamoros, Mexico, during January 1-May 13, 2023. This report describes outbreak epidemiology and outlines interim diagnostic and treatment recommendations. METHODS: Interim recommendations for diagnosis and management were developed by the Mycoses Study Group Research Education and Consortium (MSGERC) based on the clinical experience of clinicians caring for patients during the current outbreak or during previous outbreaks of healthcare-associated fungal meningitis in Durango, Mexico, and the United States...
September 22, 2023: Clinical Infectious Diseases
#10
JOURNAL ARTICLE
J W Thomas Byrd, Kay S Jones, Tandy R Freeman
Bull riders represent a microcosm of athletes in whom severe consequences of femoroacetabular impingement may challenge the limits of arthroscopic intervention. Observations of this cohort may provide meaningful insight into the treatment of other populations. All patients undergoing hip arthroscopy are prospectively assessed with a modified Harris Hip Score. Sixteen consecutive bull riders (21 hips) with minimum 2-year follow-up are reported. The average age was 26 years, duration of symptoms was 33 months, and follow-up was 57 months...
September 6, 2023: Orthopedics
#11
JOURNAL ARTICLE
Yasser F M Karar, Charles K Blend, Norman O Dronen, Asmaa Adel
The restricted concept of Astiotrema Looss, 1900 has been revised to include only eight species and various representative synonyms. However, several remaining taxa of Astiotrema (sensu lato) still need more inspection and scrutiny to determine their correct taxonomic position. Following a comprehensive review, four new genera are erected to accommodate some taxa excluded from Astiotrema (sensu stricto), three of which are closely related to this restricted concept of Astiotrema. Plesioastiotrema n. gen. is erected to accommodate Plesioastiotrema monticellii (Stossich, 1904) n...
May 12, 2023: Zootaxa
#12
JOURNAL ARTICLE
Thomas F Byrd, Bronwyn Southwell, Adarsh Ravishankar, Travis Tran, Abhinab Kc, Tom Phelan, Genevieve B Melton-Meaux, Michael G Usher, Daren Scheppmann, Sean Switzer, Gyorgy Simon, Christopher J Tignanelli
IMPORTANCE: The Deterioration Index (DTI), used by hospitals for predicting patient deterioration, has not been extensively validated externally, raising concerns about performance and equitable predictions. OBJECTIVE: To locally validate DTI performance and assess its potential for bias in predicting patient clinical deterioration. DESIGN, SETTING, AND PARTICIPANTS: This retrospective prognostic study included 13 737 patients admitted to 8 heterogenous Midwestern US hospitals varying in size and type, including academic, community, urban, and rural hospitals...
July 3, 2023: JAMA Network Open
#13
JOURNAL ARTICLE
Zeni Wu, Ruth M Pfeiffer, Doratha A Byrd, Yunhu Wan, Daniel Ansong, Joe-Nat Clegg-Lamptey, Beatrice Wiafe-Addai, Lawrence Edusei, Ernest Adjei, Nicholas Titiloye, Florence Dedey, Francis Aitpillah, Joseph Oppong, Verna Vanderpuye, Ernest Osei-Bonsu, Casey L Dagnall, Kristine Jones, Amy Hutchinson, Belynda D Hicks, Thomas U Ahearn, Rob Knight, Richard Biritwum, Joel Yarney, Seth Wiafe, Baffour Awuah, Kofi Nyarko, Montserrat Garcia-Closas, Rashmi Sinha, Jonine D Figueroa, Louise A Brinton, Britton Trabert, Emily Vogtmann
The human fecal and oral microbiome may play a role in the etiology of breast cancer through modulation of endogenous estrogen metabolism. This study aimed to investigate associations of circulating estrogens and estrogen metabolites with the fecal and oral microbiome in postmenopausal African women. A total of 117 women with fecal (N = 110) and oral (N = 114) microbiome data measured by 16S rRNA gene sequencing, and estrogens and estrogen metabolites data measured by liquid chromatography tandem mass spectrometry were included...
June 21, 2023: Microbiology Spectrum
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REVIEW
Ashley Disantis, Antonio J Andrade, Alexander Baillou, Nicolas Bonin, Thomas Byrd, Ashley Campbell, Benjamin Domb, Holly Doyle, Keelan Enseki, Barry Getz, Lucie Gosling, Louise Grant, Victor M Ilizaliturri, Dave Kohlrieser, Jovan Laskovski, Liran Lifshitz, Ryan P McGovern, Katie Monnington, John O'Donnell, Amir Takla, Tim Tyler, Mike Voight, Thomas Wuerz, RobRoy L Martin
The 2022 International Society of Hip Preservation (ISHA) physiotherapy agreement on assessment and treatment of greater trochanteric pain syndrome (GTPS) was intended to present a physiotherapy consensus on the assessment and surgical and non-surgical physiotherapy management of patients with GTPS. The panel consisted of 15 physiotherapists and eight orthopaedic surgeons. Currently, there is a lack of high-quality literature supporting non-operative and operative physiotherapy management. Therefore, a group of physiotherapists who specialize in the treatment of non-arthritic hip pathology created this consensus statement regarding physiotherapy management of GTPS...
January 2023: Journal of Hip Preservation Surgery
#15
JOURNAL ARTICLE
W Michael Pullen, Kinsley Pierre, Ivan Wong, Stephen K Aoki, T Sean Lynch, Richard C Mather, Olufemi R Ayeni, J W Thomas Byrd, Marc R Safran
BACKGROUND: Magnetic resonance imaging (MRI) scans and radiographs are often utilized in assessing for preoperative osteoarthritis in patients undergoing hip preservation surgery. PURPOSE: To determine if MRI scans improve inter- or intrarater reliabilities over radiographs for findings of hip arthritis. STUDY DESIGN: Cohort study (Diagnosis); Level of evidence, 3. METHODS: Anteroposterior and cross-table lateral radiographs as well as a representative coronal and sagittal T2-weighted MRI scan were reviewed for 50 patients by 7 experienced subspecialty hip preservation surgeons, with a minimum experience of 10 years...
April 27, 2023: American Journal of Sports Medicine
#16
JOURNAL ARTICLE
W Michael Pullen, Dominic S Carreira, Ivan Wong, Stephen K Aoki, T Sean Lynch, Richard C Mather, Olufemi R Ayeni, J W Thomas Byrd, Marc R Safran
BACKGROUND: The presence of pre-existing osteoarthritis (OA) has been associated with poor results after hip arthroscopic surgery. There is limited evidence validating the currently available grading systems of hip OA in patients undergoing hip preservation. PURPOSE/HYPOTHESIS: Our purpose was to evaluate the interobserver and intraobserver reliabilities of 2 grading systems in a group of patients undergoing hip preservation: the Tönnis grading system and a simple 4-choice Likert scale...
January 16, 2023: American Journal of Sports Medicine
#17
JOURNAL ARTICLE
Marina S Boukhvalova, Emma Mortensen, Jessica Caple, John Joseph, Fatoumata Sylla, Arash Kamali, Daniel Stylos, Diego Lopez, Thomas March, Kevin Matthew Byrd, Gregory A Prince, Ariel Arndt, Adriana Kajon, Jorge C G Blanco
Heterogeneity of COVID-19 manifestations in human population is vast, for reasons unknown. Cotton rats are a clinically relevant small animal model of human respiratory viral infections. Here, we demonstrate for the first time that SARS-CoV-2 infection in cotton rats affects multiple organs and systems, targeting species- and age-specific biological processes. Infection of S. fulviventer, which developed a neutralizing antibody response and were more susceptible to SARS-CoV-2 replication in the upper respiratory tract, was accompanied by hyperplasia of lacrimal drainage-associated lymphoid tissue (LDALT), a first known report of mucosa-associated lymphoid tissue activation at the portal of SARS-CoV-2 entry...
January 14, 2023: Scientific Reports
#18
JOURNAL ARTICLE
Marlyn P Langford, Lana Srur, Thomas B Redens, William A Byrd
Noninfectious exudative conjunctivitis can be experimentally produced in rabbits by application of the apoptogenic bacterial cell wall peptidoglycan, muramyl dipeptide (MDP) to the ocular surface. The purpose of this study was to investigate the acute conjunctival cytopathology induced by unilateral ocular surface exposure to MDP. Hematoxylin and eosin staining assessed bilateral tear cytopathology and conjunctival histopathology. The caspases levels in conjunctival tissue and tears were measured in standard assays utilizing p-nitroanaline tagged caspase-specific substrates...
January 10, 2023: Experimental Eye Research
#19
REVIEW
Tanner M Johnson, Thomas F Byrd, Wendi K Drummond, Lindsey M Childs-Kean, Monica V Mahoney, Jeffrey C Pearson, Christina G Rivera
Nontuberculous mycobacteria (NTM) are a group of atypical bacteria that may cause a spectrum of clinical manifestations, including pulmonary, musculoskeletal, skin and soft tissue, and cardiac infections. Antimycobacterial medication regimens for NTM infections require multiple agents with prolonged treatment courses and are often associated with poor tolerance in patients and suboptimal clinical outcomes. This review summarizes NTM pharmacotherapy, including treatment concepts, preferred medication regimens according to NTM species and site of infection, and emerging treatment methods for difficult-to-treat species...
February 2023: Infectious Diseases and Therapy
#20
JOURNAL ARTICLE
Audrey Nava, Andrew C Hahn, Terry H Wu, Thomas F Byrd
INTRODUCTION: Human pulmonary infection with non-tuberculous mycobacteria (NTM) such as Mycobacterium abscessus (Mabs) occurs in seemingly immunocompetent patients with underlying structural lung disease such as bronchiectasis in which normal ciliary function is perturbed. In addition to alterations in mucociliary clearance, the local immunologic milieu may be altered in patients with structural lung disease, but the nature of these changes and how they relate to NTM persistence remain unclear...
2022: Frontiers in Immunology
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