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https://www.readbyqxmd.com/read/27888401/the-impact-of-chronic-hepatitis-c-infection-on-cholesterol-metabolism-in-pbmcs-is-associated-with-microrna-146a-expression
#1
M Sidorkiewicz, M Grek, B Jozwiak, A Krol, A Piekarska
Chronic hepatitis C (CHC) infection is known to induce important changes in host cholesterol metabolism. MicroRNAs (miRNAs) regulate the expression of many genes and, in consequence, control various processes, including human metabolism and response to viral infection. Recently, the alteration of the immune-associated miR-146a, which is abundantly present in peripheral blood mononuclear cells (PBMCs), was found in some viral infections. The study aimed to analyse the influence of hepatitis C virus (HCV) infection on miR-146a expression in PBMCs in vivo and in vitro, as well as to assess the possible impact of miR-146a alteration on the intracellular cholesterol level in PBMCs...
November 25, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27882070/serological-patterns-and-molecular-characterization-of-occult-hepatitis-b-virus-infection-among-blood-donors
#2
Hong Lin, Hong Zhao, Xinyi Tang, Wenjia Hu, Nizheng Jiang, Shaowen Zhu, Chengyin Huang
BACKGROUND: Hepatitis B infections, characterized by the presence of a viral genome without detectable hepatitis B surface antigen (HBsAg; Occult hepatitis B infection [OBI]), have been reported recently. OBJECTIVES: We performed serological and molecular characterization of OBI among blood donors at Jiangsu province blood center during years 2013 and 2014. METHODS: All donor samples were routinely screened by double enzyme-linked immunosorbent assay (ELISA) for hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), Treponema pallidum (TP), and alanine aminotransferase (ALT)...
October 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27822257/co-infection-of-the-hepatitis-c-virus-with-other-blood-borne-and-hepatotropic-viruses-among-hemophilia-patients-in-poland
#3
Marta Kucharska, Malgorzata Inglot, Aleksandra Szymczak, Weronika Rymer, Malgorzata Zalewska, Krzysztof Malyszczak, Urszula Zaleska-Dorobisz, Malgorzata Kuliszkiewicz-Janus
BACKGROUND: The prevalence of HCV infection in people with hemophilia is substantially higher than that in the general population (63% - 98%). Multiple transfusions and substitutive therapy have also been linked to a high risk of HBV and HIV transmission. However, the prevalence of other blood-borne viral infections in this population is less well known. OBJECTIVES: This study aimed to assess the prevalence of co-infection with HBV and other blood-borne viruses in Polish HCV-infected hemophiliacs...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27788631/detection-of-occult-hepatitis-b-and-window-period-infection-among-blood-donors-by-individual-donation-nucleic-acid-testing-in-a-tertiary-care-center-in-south-india
#4
Cinzia S Keechilot, Veena Shenoy, Anil Kumar, Lalitha Biswas, Sukhithasri Vijayrajratnam, Kavitha Dinesh, Prem Nair
With the introduction of highly sensitive hepatitis B surface antigen immunoassay, transfusion associated HBV infection have reduced drastically but they still tend to occur due to blood donors with occult hepatitis B infection (OBI) and window period (WP) infection. Sera from, 24338 healthy voluntary blood donors were screened for HBsAg, HIV and HCV antibody using Vitros Enhanced Chemiluminescent Immunoassay. The median age of the donor population was 30 (range 18-54) with male preponderance (98%). All serologically negative samples were screened by nucleic acid testing (NAT) for viral DNA and RNA...
October 27, 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27773912/study-on-evaluation-of-alanine-aminotransferase-alt-as-surrogate-marker-in-hepatitis-virus-test
#5
Daisuke Ikeda, Makiko Sugawa, Kazuo Kawahara
Nucleic acid amplification test (NAT), which was introduced by the Japanese Red Cross Society in October 1999, began to be performed for screening of blood transfusion formulations in Japan in August 2014. In this study, the precision of immunological screenings of hepatitis B (HBsAg, HBcAb, and HBsAb), hepatitis C (HCVAb), and human immunodeficiency (HIVAb) virus antigens in donated blood were evaluated. In addition, the sensitivity of the alanine aminotransferase (ALT) test for detection of the hepatitis B and C viruses was re-evaluated...
2016: Journal of Medical and Dental Sciences
https://www.readbyqxmd.com/read/27723770/deciding-on-interferon-free-treatment-for-chronic-hepatitis-c-updating-liver-stiffness-cut-off-values-to-maximize-benefit
#6
Agostino Colli, Mirella Fraquelli, Daniele Prati, Alessia Riva, Alessandra Berzuini, Dario Conte, Alessio Aghemo, Massimo Colombo, Giovanni Casazza
INTRODUCTION: In a perspective of economic constraints the prioritizing of patients to IFN-free regimens is mainly based on the determination of liver stiffness by transient elastography (TE). Being a continuous variable the interpretation of TE results requires the identification of cut-off values, to date set to maximize diagnostic accuracy even if such values should be better based on more helpful outcome prediction endpoints. AIM: To define the TE cut-off values in different clinical scenarios, including new IFN-free regimens, and to balance the clinical benefits versus harms in treated and untreated patients...
2016: PloS One
https://www.readbyqxmd.com/read/27723449/selection-strategies-for-newly-registered-blood-donors-in-european-countries
#7
Ryanne W Lieshout-Krikke, Dragoslav Domanovic, Wim De Kort, Wolfgang Mayr, Giancarlo M Liumbruno, Simonetta Pupella, Johann Kurz, Folke Knutson, Sheila Maclennan, Gilles Folléa
BACKGROUND: Two selection strategies for newly-registered blood donors are available: a single-visit selection called the standard selection procedure (SSP), and a two-stage selection named pre-donation and donation screening (PDS). This study reviews the selection strategies for newly-registered donors currently applied in European countries. MATERIAL AND METHODS: We collected data on donor selection procedures, blood donation, laboratory screening and HIV, HCV and HBV positive donors/donations from 2010 to 2013 in 30 European countries by using questionnaires...
September 27, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27716251/seroprevalence-of-human-immunodeficiency-virus-hepatitis-b-and-c-viruses-and-treponema-pallidum-infections-among-blood-donors-at-shiyan-central-china
#8
Shuguo Yang, Danmei Jiao, Changjun Liu, Ming Lv, Shan Li, Zongyun Chen, Yao Deng, Yanqing Zhao, Jian Li
BACKGROUND: Ordinary screening of transfusion-transmissible infections (TTIs) among blood donors is essential for blood transfusion. Although there is several TTIs studies focus on human immunodeficiency virus, hepatitis B and C viruses, and Treponema pallidum infections in China, it is no data to illustrate any firm conclusion from Shiyan City, Central China. It aims to verify the seroprevalence of TTIs among blood donors at Shiyan. METHODS: A retrospective analysis of blood donors' information was conducted for the presence of HIV, HBV, HCV and T...
October 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27696441/cost-effectiveness-of-adding-nucleic-acid-testing-to-hepatitis-b-hepatitis-c-and-human-immunodeficiency-virus-screening-of-blood-donations-in-zimbabwe
#9
Nyashadzaishe Mafirakureva, Tonderai Mapako, Star Khoza, Jean C Emmanuel, Lucy Marowa, David Mvere, Maarten J Postma, Marinus van Hulst
BACKGROUND: The aim of this study was to assess the cost effectiveness of introducing individual-donation nucleic acid testing (ID-NAT), in addition to serologic tests, compared with the exclusive use of serologic tests for the identification of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) I and II among blood donors in Zimbabwe. STUDY DESIGN AND METHODS: The costs, health consequences, and cost effectiveness of adding ID-NAT to serologic tests, compared with serologic testing alone, were estimated from a health care perspective using a decision-analytic model...
October 2, 2016: Transfusion
https://www.readbyqxmd.com/read/27679708/the-prevalence-of-sen-virus-and-occult-hepatitis-b-obi-virus-infection-among-blood-donors-in-ahvaz-city
#10
Samaneh Abbasi, Manoochehr Makvandi, Gharib Karimi, Niloofar Neisi
BACKGROUND: The SEN virus (SENV) is a prevalent blood borne pathogen that has a worldwide incidence. SENV is comprised of eight genotypes; genotypes H and D are frequently associated with the pathogenesis of non-A - E hepatitis and post-transfusion hepatitis in blood donors and hepatitis patients. So far, no SENV pathogenesis has been reported in the liver biopsies of SENV carriers, but the frequency of SENV and its related genotypes requires further molecular epidemiology studies in different regions of the world...
July 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27673429/prevalence-of-anti-hepatitis-c-cirus-antibody-among-pregnant-women-and-blood-donors-at-bowen-university-teaching-hospital-ogbomoso-oyo-state-nigeria
#11
Awoyelu E Hilda, Oloke Julius Kola, Oladipo E Kolawole
Hepatitis C virus is one of the emerging infectious diseases that can be transmitted through blood-to-blood contact. This study was carried out to determine the prevalence of anti-HCV antibodies among potential blood donors and pregnant women attending Bowen University Teaching Hospital (BUTH), Ogbomoso, Oyo State. Hospital based study was conducted from December 2014 to September 2015. The study group (N = 279) included potential blood donors and pregnant women. Data on socio-demographic characteristics and potential risk factors were collected using a structured questionnaire...
September 27, 2016: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/27672281/dried-blood-spots-valid-screening-for-viral-hepatitis-and-human-immunodeficiency-virus-in-real-life
#12
Belinda K Mössner, Benjamin Staugaard, Janne Jensen, Søren Thue Lillevang, Peer B Christensen, Dorte Kinggaard Holm
AIM: To detect chronic hepatitis B (CHB), chronic hepatitis C (CHC) and human immunodeficiency virus (HIV) infections in dried blood spot (DBS) and compare these samples to venous blood sampling in real-life. METHODS: We included prospective patients with known viral infections from drug treatment centers, a prison and outpatient clinics and included blood donors as negative controls. Five drops of finger capillary blood were spotted on filter paper, and a venous blood sample was obtained...
September 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27641977/preferential-association-of-hepatitis-c-virus-with-cd19-b-cells-is-mediated-by-complement-system
#13
Richard Y Wang, Patricia Bare, Valeria De Giorgi, Kentaro Matsuura, Kazi Abdus Salam, Teresa Grandinetti, Cathy Schechterly, Harvey J Alter
: Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood. Recent studies have found that HCV in peripheral blood mononuclear cells from chronically infected patients is mainly associated with cluster of differentiation 19-positive (CD19(+) ) B cells. To further elucidate this preferential association of HCV with B cells, we used in vitro cultured virus and uninfected peripheral blood mononuclear cells from healthy blood donors to investigate the necessary serum components that activate the binding of HCV to B cells...
December 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27640362/cd14-monocyte-derived-galectin-9-induces-nk-cell-cytotoxicity-in-chronic-hepatitis-c
#14
Akira Nishio, Tomohide Tatsumi, Takatoshi Nawa, Takahiro Suda, Teppei Yoshioka, Yoshiki Onishi, Satoshi Aono, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Daisuke Okuzaki, Takasuke Fukuhara, Yoshiharu Matsuura, Naoki Hiramatsu, Tetsuo Takehara
: NK cell activation is associated with both liver injury and persistent infection in chronic hepatitis C (CHC); however, the detail mechanism of this activation has not yet been fully elucidated. As Galectin-9 (Gal-9) is reported to be increased in the serum and liver tissue of CHC patients, we investigated the function of Gal-9 in NK cell activation in CHC. First, we evaluated the function of Gal-9 on NK cytotoxicity in vitro. Gal-9 treatment resulted in increased cytotoxicity of naïve NK cells, and the Gal-9-activated NK cells demonstrated cytotoxicity toward hepatoma cells and T cells...
September 19, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27636506/analytical-performance-of-the-veris-mdx-system-hcv-assay-for-detecting-and-quantifying-hcv-rna
#15
Karine Sauné, Florence Abravanel, Catherine Haslé, Jérôme Boineau, Catherine Mengelle, Jacques Izopet
BACKGROUND: The diagnosis of HCV relies on the detection of viral RNA. OBJECTIVE: To evaluate the performance of the VERIS/MDx System HCV Assay, a new automated system for quantifying HCV RNA, and to compare with the COBAS(®) Ampliprep/COBAS(®) Taqman™ (CAPCTM) HCV Test version 2.0. STUDY DESIGN: The limit of detection was determined by Probit analysis with the 3rd International WHO HCV standard and precision by assaying in duplicate control samples with HCV RNA concentrations of 7...
September 13, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27611688/epidemic-history-of-hepatitis-c-virus-among-patients-with-inherited-bleeding-disorders-in-iran
#16
Katayoun Samimi-Rad, Ramin Rahimnia, Mahdi Sadeghi, Seyed Amir Malekpour, Mona Marzban, Maryam Keshvari, Seyed Jalal Kiani, Seyed-Moayed Alavian
The high rate of hepatitis C virus (HCV) infection among transfusion related risk groups such as patients with inherited bleeding disorders highlighting the investigation on prevalent subtypes and their epidemic history among this group. In this study, 166 new HCV NS5B sequences isolated from patients with inherited bleeding disorders together with 29 sequences related to hemophiliacs obtained from a previous study on diversity of HCV in Iran were analyzed. The most prevalent subtype was 1a (65%), followed by 3a (18...
2016: PloS One
https://www.readbyqxmd.com/read/27610403/hepatitis-c-virus-in-north-africa-an-emerging-threat
#17
REVIEW
Mohamed A Daw, Abdallah El-Bouzedi, Mohamed O Ahmed, Aghnyia A Dau, Mohamed M Agnan
Hepatitis C virus is a major public health threat associated with serious clinical consequences worldwide. North Africa is a unique region composed of seven countries that vary considerably in the predisposing factors to microbial diseases both historically and at the present time. The dynamics of HCV in the region are not well documented. The data are both limited and controversial in most of the countries in the region. In North Africa, the epidemiology of HCV is disparate and understanding it has been hampered by regional "epidemiological homogeneity" concepts...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27605850/a-study-on-confidential-unit-exclusion-at-shiraz-blood-transfusion-center-iran
#18
Leila Kasraian, Mohammad Hossein Karimi
BACKGROUND: Confidential unit exclusion (CUE) system has been designed to enhance transfusion safety as an extra additive approach. AIMS: This study was designed to survey demographic characteristics, prevalence of serologic markers, and reasons of opting CUE. MATERIALS AND METHODS: The cross-sectional study was performed at Shiraz Blood Transfusion Center (Southern Iran). CUE is used for all individuals who refer for blood donation, and donors can choose their blood not to be used if they have any doubt about their blood suitability for transfusion...
July 2016: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/27601496/cost-effectiveness-of-screening-for-hepatitis-c-virus-a-systematic-review-of-economic-evaluations
#19
Stephanie Coward, Laura Leggett, Gilaad G Kaplan, Fiona Clement
OBJECTIVES: With the developments of near-cures for hepatitis C virus (HCV), who to screen has become a high-priority policy issue in many western countries. Cost-effectiveness of screening programmes should be one consideration when developing policy. The objective of this work is to synthesise the cost-effectiveness of HCV screening programmes. SETTING: A systematic review was completed. 5 databases were searched until May 2016 (NHSEED, MEDLINE, the HTA Health Technology Assessment Database, EMBASE, EconLit)...
2016: BMJ Open
https://www.readbyqxmd.com/read/27597875/transfusion-transmissible-infections-among-voluntary-blood-donors-at-wolaita-sodo-university-teaching-referral-hospital-south-ethiopia
#20
Fithamlak Solomon Bisetegen, Fanuel Belayneh Bekele, Temesgen Anjulo Ageru, Fiseha Wadilo Wada
Background. Transfusion-transmissible infections, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis are among the greatest threats to blood safety and pose a serious public health problem. Objective. To determine the magnitude of blood borne infections among blood donors at Wolaita Sodo University Teaching Referral Hospital. Methods and Materials. A cross-sectional study was conducted from 10/11/2015 up to 10/12/2015. 390 donors were consecutively included and data on donor's age, sex, blood type, and serum screening results were obtained by structured questionnaire and laboratory investigation...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
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