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HCV BLOOD DONORS

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https://www.readbyqxmd.com/read/29020289/a-novel-human-pegivirus-hpgv-2-hhpgv-1-is-tightly-associated-with-hcv-infection-and-hcv-hiv-1-co-infection
#1
Haiying Wang, Zhengwei Wan, Ru Xu, Yujuan Guan, Nalin Zhu, Jianping Li, Zhiwei Xie, Aiqi Lu, Fuchun Zhang, Yongshui Fu, Shixing Tang
Background: HPgV-2 is a novel blood-borne human pegivirus that mainly infects HCV-infected subjects. We have investigated the prevalence of HPgV-2 in China, its association with HCV and HIV-1, and the impact on HCV viral load and liver damage. Methods: A cross-sectional study was conducted with both blood donors and HCV- and HIV-1-infected patients in Guangzhou, China. All subjects were screened for antiHPgV-2 and HPgV-2 RNA. Demographic and clinical information were obtained from electronic medical records...
August 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28994164/utilization-of-increased-risk-for-transmission-of-infectious-disease-donor-organs-in-solid-organ-transplantation-retrospective-analysis-of-disease-transmission-and-safety
#2
Linda Irwin, Camille N Kotton, Nahel Elias, Julie Palafox, Debra Basler, Sarah H Shao, William Lester, Xiaofeng Zhang, Brendan Kimball, Carrie Trencher, Jay A Fishman
The inadequate supply of transplantable organs necessitates new approaches to organ availability. Serologies and nucleic acid testing (NAT) for hepatitis C virus (HCV), hepatitis B virus (HBV), and human immunodeficiency virus (HIV) are used in microbiologic screening of potential organ donors. Organs from donors considered at "high risk" (Centers for Disease Control and Prevention, CDC 1994) or "increased risk" (U.S. Public Health Service, PHS 2013) for transmission of viral infection to recipients may provide an expanded source of organs for transplantation...
October 10, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28982042/evaluation-of-clinical-sensitivity-and-specificity-of-hepatitis-b-virus-hbv-hepatitis-c-virus-and-human-immunodeficiency-virus-1-by-cobas-mpx-detection-of-occult-hbv-infection-in-an-hbv-endemic-area
#3
Jihye Ha, Younhee Park, Hyon-Suk Kim
BACKGROUND: Transfusion-transmitted infectious diseases remain a major concern for blood safety, particularly with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). Nucleic acid testing (NAT) in donor screening shortens the serologically negative window period and reduces virus transmission. The cobas MPX (Roche Molecular Systems, Inc., Branchburg, New Jersey) is a recently developed multiplex qualitative PCR system that enables the simultaneous detection of HBV, HCV, and HIV with improved sensitivity and throughput using cobas 6800 and 8800 instruments...
September 21, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28966492/seroprevalence-of-transfusion-transmitted-infections-in-healthy-blood-donors-a-5-year-tertiary-care-hospital-experience
#4
Sushama A Chandekar, Gaythri P Amonkar, Heena M Desai, Nitin Valvi, Gururaj V Puranik
INTRODUCTION: Transfusion transmitted infections (TTIs) can cause threat to bloody safety as blood transfusion is an important mode of transmission of TTI to the recipient, hence, to prevent transmission of these diseases, screening tests on blood bags is an important step for blood safety. AIM: This study was undertaken with the aim of determining the seroprevalence of TTI in healthy blood donors in a tertiary care blood bank. MATERIALS AND METHODS: A retrospective study was carried out over a period of 5 years from January 2007 to December 2011...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28941882/investigation-of-an-algorithm-for-anti-hcv-eia-reactivity-in-blood-donor-screening-in-turkey-in-the-absence-of-nucleic-acid-amplification-screening
#5
Ayse Esra Karakoc, Rukiye Berkem, Hasan Irmak, Ali Pekcan Demiroz, Idil Yenicesu, Nigar Ertugrul, Önder Arslan, Sabri Kemahli, Sevinc Yilmaz, Osman Ozcebe, Abdurrahman Kara, Gulsum Ozet, Ziya Cibali Acikgoz, Tulin Acikgoz
PURPOSE: In this study we aimed to propose an algorithm for initial anti HCV EIA reactive blood donations in Turkey where nucleic acid amplification tests are not yet obligatory for donor screening. METHODS: A total of 416 anti HCV screening test reactive donor samples collected from 13 blood centers from three cities in Turkey were tested in duplicate by Ortho HCV Ab Version 3.0 and Radim HCV Ab. All the repeat reactive samples were tested by INNO-LIA HCV Ab 3...
September 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28935848/clinical-relevance-of-silent-red-blood-cell-autoantibodies
#6
Francesca R Mauro, Fabio Trastulli, Cristiano Alessandri, Guido Valesini, Gianluca Giovannetti, Costantino Riemma, Marika Porrazzo, Sara Pepe, Gioia Colafigli, Maria D Caputo, Maria S De Propris, Anna R Guarini, Gabriella Girelli, Serelina Coluzzi, Robin Foà
To evaluate the clinical significance of RBC autoantibodies in the absence of clinical signs of autoimmune hemolytic anemia (AHIA), we retrospectively analyzed the clinical course of 60 subjects with silent RBC autoantibodies (IgG, 24; IgM, 35; IgG+IgM, 1) diagnosed and followed at our institute. Asymptomatic RBC autoantibodies were detected in 5 (8.3%) pregnant females, 34 (56.7%) healthy individuals (blood donors, 32; subjects with abnormal agglutination of blood samples, 2) and 21 (35%) patients screened prior to surgery (benign disorders, 16; tumors, 5)...
September 21, 2017: Haematologica
https://www.readbyqxmd.com/read/28891457/current-prevalence-of-chronic-hepatitis-b-and-c-virus-infection-in-the-general-population-blood-donors-and-pregnant-women-in-the-eu-eea-a-systematic-review
#7
S H I Hofstraat, A M Falla, E F Duffell, S J M Hahné, A J Amato-Gauci, I K Veldhuijzen, L Tavoschi
This systematic review aimed at estimating chronic hepatitis B (HBV) and C virus (HCV) prevalence in the European Union (EU) and Economic Area (EEA) countries in the general population, blood donors and pregnant women. We searched PubMed©, Embase© and Cochrane Library databases for reports on HBV and HCV prevalence in the general population and pregnant women in EU/EEA countries published between 2005 and 2015. Council of Europe data were used for HBV and HCV blood donor prevalence. HBV general population estimates were available for 13 countries, ranging from 0·1% to 4·4%...
September 11, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28891069/use-of-supplemental-anti-hbc-testing-of-donors-showing-non-discriminating-reactive-results-in-multiplex-nucleic-acid-testing
#8
J W Kang, J H Seo, K W Youn, Y I Seo, K Huh, G R Choi, H K Min, D J Oh, H J Jo, J N Kim
BACKGROUND AND OBJECTIVES: The Korean Red Cross began nucleic acid amplification testing (NAT) for HIV and HCV in February 2005, and added HBV NAT beginning in June 2012. The current NAT system utilizes a multiplex assay for simultaneous detection of HBV DNA, HCV RNA and HIV-1 RNA. For samples that are reactive in the multiplex assay, we do specific tests for each virus. However, there have been cases of non-discriminated reactive (NDR) results which appear to be the result of non-specific reactions or cross-contamination, although some cases are considered to arise from the presence of low levels of HBV DNA due to occult hepatitis B infection...
September 10, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28866696/multiplex-real-time-rt-pcr-assay-for-transfusion-transmitted-viruses-in-sero-negative-allogeneic-blood-donors-an-experience-from-southern-pakistan
#9
S Sultan, M I Nasir, S Rafiq, M A Baig, S Akbani, S M Irfan
BACKGROUND: Blood transfusion safety commences with healthy donor recruitment. The threat of transfusion transmitted infections is greatly minimized by serological tools but not entirely eliminated. Recently, nucleic-acid testing for blood donor screening has virtually eliminated this jeopardy. METHODS: This prospective study was conducted from February 2015 to February 2016. Samples from seronegative donors were run on multiplex assay (Cobas, S-201 system platform, Roche) in a batch of six [MP-NAT]...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28859680/prevalence-of-human-pegivirus-1-and-sequence-variability-of-its-e2-glycoprotein-estimated-from-screening-donors-of-fetal-stem-cell-containing-material
#10
Yakov Vitrenko, Iryna Kostenko, Kateryna Kulebyakina, Khrystyna Sorochynska
BACKGROUND: Human pegivirus-1 (HPgV-1) is a member of the Flaviviridae family whose genomic organization and mode of cellular entry is similar to that of hepatitis C virus (HCV). The E2 glycoprotein of HPgV-1 is the principle mediator in the virus-cell interaction and as such harbors most of HPgV-1's antigenic determinants. HPgV-1 persists in blood cell precursors which are increasingly used for cell therapy. METHODS: We studied HPgV-1 prevalence in a large cohort of females donating fetal tissues for clinical use...
August 31, 2017: Virology Journal
https://www.readbyqxmd.com/read/28854790/neopterin-and-soluble-cd14-levels-as-indicators-of-immune-activation-in-cases-with-low-anti-hcv-reactivity-and-true-hcv-infection
#11
Z Habip, P Sohrabi, S Saribas, R Caliskan, M Demirci, A Karakullukcu, K Atalik, P Yuksel, O Uysal, E Kosan, H Bahar Tokman, B Kocazeybek
Neopterin and soluble CD14 (sCD14) are detected at high levels in hepatitis C virus (HCV) infections. We aimed to evaluate the role of these plasma immune activation biomarkers, for the indirect assessment of immune activation status of patients with low anti-HCV reactivity and a HCV infection. Low anti-HCV reactivity group (LRG, n: 70), true positive HCV infection group (THG, 30) and healthy control group (HCG, 30) were analyzed in this study. We have used ELISA, HCV RIBA/LIA and HCV-RNA methods. Mean neopterin levels were significantly lower in LRG than THG (p <0...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28851778/seroprevalence-of-hepatitis-c-virus-infection-in-cameroon-a-systematic-review-and-meta-analysis
#12
Jean Joel Bigna, Marie A Amougou, Serra Lem Asangbeh, Angeladine Malaha Kenne, Jobert Richie Nansseu
OBJECTIVE: Better knowledge of hepatitis C virus (HCV) seroprevalence at the national level can help to implement pertinent strategies to address the HCV-related burden. The aim of this paper was to estimate the seroprevalence of HCV infection in Cameroon. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: People residing in Cameroon. DATA SOURCES: Electronic databases including PubMed/MEDLINE, AJOL, WHO-Afro Library, Africa Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon from 1 January 2000 to 15 December 2016 were searched...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28838454/acute-graft-rejection-and-formation-of-de-novo-donor-specific-antibodies-triggered-by-low-cyclosporine-levels-and-interferon-therapy-for-recurrent-hepatitis-c-infection-after-liver-transplantation-a-case-report
#13
R Nakano, M Ohira, K Ishiyama, K Ide, T Kobayashi, H Tahara, S Shimizu, K Arihiro, M Imamura, K Chayama, Y Tanaka, H Ohdan
BACKGROUND: We report a case of acute rejection of a liver graft, together with the occurrence of de novo donor-specific antibodies (DSAs), in a 53-year-old Japanese man who had undergone deceased-donor liver transplantation. METHODS: The graft rejection was triggered by low cyclosporine levels and pegylated interferon treatment for the recurrence of hepatitis C virus (HCV) infection 18 months after transplantation. Although the graft was ABO-compatible, pre-formed DSA B51 was detected; therefore, total plasma exchange was performed and intravenous rituximab (500 mg/body) was administered before transplantation...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28795466/reduced-prevalence-of-hepatitis-b-surface-antigen-positivity-among-pregnant-women-born-after-the-national-implementation-of-immunoprophylaxis-for-babies-born-to-hepatitis-b-virus-carrier-mothers-in-japan
#14
Aya Sugiyama, Masayuki Ohisa, Shintaro Nagashima, Chikako Yamamoto, Chuon Channarena, Toshiko Fujii, Tomoyuki Akita, Keiko Katayama, Yoshiki Kudo, Junko Tanaka
AIM: We aimed to estimate hepatitis B surface antigen (HBsAg) positivity among birth year-stratified pregnant women in Hiroshima, Japan, and compare prevalence rates among women between born before and after implementation of a national immunoprophylactic vaccination program for babies born to hepatitis B virus (HBV) carrier mothers in Japan. METHODS: Pregnant women who gave birth at all delivery hospitals/clinics in Hiroshima prefecture between April 1, 2010 and March 31, 2011 were eligible...
August 9, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28792071/high-prevalence-of-hbv-infection-detection-of-subgenotypes-f1b-a2-and-d4-and-differential-risk-factors-among-mexican-risk-populations-with-low-socioeconomic-status
#15
Alexis Jose-Abrego, Arturo Panduro, Nora A Fierro, Sonia Roman
Hepatitis B virus (HBV) infection may be underestimated among high-risk individuals in regions of low HBs antigenemia. This study aimed to assess HBV serological markers, genotypes, and risk factors in Mexican patients with risk of HBV infection and low socioeconomic status. Demographics, clinical, and risk factor data were collected in patients with HIV (n = 289), HCV (n = 243), deferred blood donors (D-BD) (n = 83), and two native populations, Mixtecos (n = 57) and Purepechas (n = 44)...
December 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28780074/intra-hepatic-depletion-of-mucosal-associated-invariant-t-cells-in-hepatitis-c-virus-induced-liver-inflammation
#16
Fabian J Bolte, Ashley C O'Keefe, Lauren M Webb, Elisavet Serti, Elenita Rivera, T Jake Liang, Marc Ghany, Barbara Rehermann
BACKGROUND & AIMS: Chronic hepatitis affects phenotypes of innate and adaptive immune cells. Mucosal associated invariant T (MAIT) cells are enriched in the liver as compared to the blood, respond to intra-hepatic cytokines, and (via the semi-invariant T-cell receptor) to bacteria translocated from the gut. Little is known about the role of MAIT cells in livers of patients with chronic hepatitis C virus (HCV) infection and their fate after antiviral therapy. METHODS: We collected blood samples from 42 patients with chronic HCV infection who achieved a sustained virologic response after 12 weeks of treatment with sofosbuvir and velpatasvir...
August 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28750638/erratum-to-prevalence-of-anelloviruses-ttv-ttmdv-and-ttmv-in-healthy-blood-donors-and-in-patients-infected-with-hbv-or-hcv-in-qatar
#17
Ahmed A Al-Qahtani, Enas S Alabsi, Raed AbuOdeh, Lukman Thalib, Mohamed E El Zowalaty, Gheyath K Nasrallah
No abstract text is available yet for this article.
July 27, 2017: Virology Journal
https://www.readbyqxmd.com/read/28736010/predictors-of-mortality-in-living-donor-liver-transplantation
#18
S Elkholy, S Mogawer, A Hosny, M El-Shazli, U M Al-Jarhi, S Abdel-Hamed, A Salah, N El-Garem, A Sholkamy, M El-Amir, M S Abdel-Aziz, A Mukhtar, A El-Sharawy, A Nabil
BACKGROUND: Egypt has the highest prevalence of the world hepatitis C virus (HCV) load. Hence, the problem of end-stage liver disease (ESLD) is considered a huge burden on the community. Living donor liver transplantation (LDLT) is the only source of donation in Egypt till now. Survival rates had shown significant improvement in the past decades. This study provides analysis of the mortality rates and possible predictors of mortality following LDLT. It also aids in developing a practical and easy-to-apply risk index for prediction of early mortality...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28709845/fifteen-years-of-nucleic-acid-testing-in-france-results-and-lessons
#19
S Laperche, P Tiberghien, C Roche-Longin, J Pillonel
Of the 40 million donations screened with Nucleic acid testing (NAT) between July 2001 and December 2015 in France, 20 HIV-positive, 13 HCV-positive and 17 HBV (HBV-NAT was initiated in 2005 and extended to the whole country in 2010) donations were discarded thanks to NAT. The main benefit in terms of discarded donations is related to HBV with a yield of 0.88 per million donations, which is 12.5 and 1.8 times higher than for HCV and HIV respectively. The main risk factor found in these donors during the post donation interview was having sex with men for males (n=11, all repeat blood donors), having a partner HCV positive (n=6) or at-risk partner (originated from endemic area or HBV positive) for HBV (n=8) for HIV, HCV and HBV, respectively...
July 11, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28702098/hepatitis-b-and-c-seroprevalence-in-patients-with-diabetes-mellitus-and-its-relationship-with-microvascular-complications
#20
Kadir Gisi, Ali Cetinkaya, Mesut Ozkaya, Bulent Kantarceken, Gokce Gisi, Sedat Koroglu
INTRODUCTION: Diabetic patients are susceptible to bacterial, viral and fungal infections because of various deficiencies in the immune system. AIM: To investigate a possible link between hepatitis B/C prevalence and microvascular complications as well as duration of diabetes. MATERIAL AND METHODS: In total 1263 diabetic patients (1149 type 2, 114 type 1) were enrolled in the study. The control group consisted of 1482 healthy blood donors who were over 40 years old...
2017: Przegla̜d Gastroenterologiczny
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