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https://www.readbyqxmd.com/read/28427072/anti-vascular-endothelial-growth-factor-injections-the-new-standard-of-care-in-proliferative-diabetic-retinopathy
#1
Xintong Li, Marco A Zarbin, Neelakshi Bhagat
For decades, panretinal photocoagulation (PRP) has been the standard of care for the treatment of proliferative diabetic retinopathy (PDR). The relatively recent advent of anti-vascular endothelial growth factor (VEGF) formulations for intravitreal injection has provided a fresh perspective on PDR treatment, especially in eyes with concurrent diabetic macular edema (DME). The anti-VEGF agent ranibizumab has demonstrated a potentially protective effect on eyes with DME in terms of progression to PDR in the RIDE/RISE trials, as has aflibercept in the VIVID/VISTA trials...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28418204/modeling-aesthetics-to-support-an-ecosystem-services-approach-for-natural-resource-management-decision-making
#2
Pieter N Booth, Sheryl A Law, Jane Ma, John Buonogurio, James Boyd, Jessica Turnley
This paper reviews literature on aesthetics and describes the development of vista and landscape aesthetics models. Spatially explicit variables were chosen to represent physical characteristics of natural landscapes that are important to aesthetic preferences. A vista aesthetics model evaluates the aesthetics of natural landscapes viewed from distances over 1,000 m. and a landscape aesthetics model evaluates the aesthetic value of wetlands and forests within 1,000 m from the viewer. Each of the model variables is quantified using spatially-explicit metrics on a pixel-specific basis within EcoAIM™, a GIS-based ecosystem services decision analysis support tool...
April 18, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28416578/quantitative-mass-spectrometry-analysis-of-pd-l1-protein-expression-n-glycosylation-and-expression-stoichiometry-with-pd-1-and-pd-l2-in-human-melanoma
#3
Carlos A Morales-Betanzos, Hyoungjoo Lee, Paula I Gonzalez-Ericsson, Justin M Balko, Douglas B Johnson, Lisa J Zimmerman, Daniel C Liebler
Quantitative assessment of key proteins that control the tumor-immune interface is one of the most formidable analytical challenges in immunotherapeutics. We developed a targeted mass spectrometry (MS) platform to quantify programmed cell death-1 (PD-1), programmed cell death 1 ligand 1 (PD-L1), and programmed cell death 1 ligand 2 (PD-L2) at fmol/microgram protein levels in formalin fixed, paraffin-embedded sections from 22 human melanomas. PD-L1 abundance ranged 50-fold, from approximately 0.03 to 1.5 fmol/microgram protein and the PRM data were largely concordant with total PD-L1-positive cell content, as analyzed by immunohistochemistry (IHC) with the E1L3N antibody...
April 17, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28416316/effect-of-passive-ultrasonic-activation-on-organic-tissue-dissolution-from-simulated-grooves-in-root-canals-using-sodium-hypochlorite-with-or-without-surfactants-and-edta
#4
Roberto Estevez, Antonio J Conde, Oliver Valencia de Pablo, Francisco de la Torre, Giampiero Rossi-Fedele, Rafael Cisneros
INTRODUCTION: The aim of this study was to evaluate the porcine palatal mucosa dissolution from artificial grooves using a final rinse with sodium hypochlorite (NaOCl) with or without a surfactant or ultrasonic activation (PUI). METHODS: The root canals of 130 human maxillary central incisors were chemomechanically prepared and the teeth split. A standardized longitudinal intracanal groove was created in 1 of the root halves. One hundred thirty porcine palatal mucosa samples were collected, adapted in order to fit into the grooves, and weighed...
April 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28412813/singlet-oxygen-detection-on-a-nanostructured-porous-silicon-thin-film-via-photonic-luminescence-enhancements
#5
S N Aisyiyah Jenie, Sally E Plush, Nicolas H Voelcker
Because reactive oxygen species are involved in a range of pathologies, developing analytical tools for this group of molecules opens new vistas for biomedical diagnostics. Herein, we fabricate a porous silicon microcavity (pSiMC) functionalized with luminescent singlet oxygen ((1)O2) probe EuA ((Eu(III)-2,2',2″-(10-(2-((4-(2-((4-(2-((anthracen-9-ylmethyl)amino)ethyl)-1H-1,2,3-triazol-1-yl)amino)-2-oxoethyl)-2-oxo-1,2-dihydroquinolin-7-yl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid) as proof of concept of an optical sensor for reactive oxygen species...
April 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28411205/vista-upregulation-may-promote-resistance-to-ctla-4-blockade
#6
(no author information available yet)
CTLA-4 blockade with ipilimumab activates the immune inhibitory VISTA checkpoint in prostate cancer.
April 14, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28399140/collinear-hox-hox-interactions-are-involved-in-patterning-the-vertebrate-anteroposterior-a-p-axis
#7
Kongju Zhu, Herman P Spaink, Antony J Durston
Investigating regulation and function of the Hox genes, key regulators of positional identity in the embryo, opened a new vista in developmental biology. One of their most striking features is collinearity: the temporal and spatial orders of expression of these clustered genes each match their 3' to 5' order on the chromosome. Despite recent progress, the mechanisms underlying collinearity are not understood. Here we show that ectopic expression of 4 different single Hox genes predictably induces and represses expression of others, leading to development of different predictable specific sections of the body axis...
2017: PloS One
https://www.readbyqxmd.com/read/28398408/-uno-studio-sul-processo-di-riconciliazione-terapeutica-del-paziente-in-un-ospedale-oncologico
#8
Frida Gorreja, Vera Damuzzo, Umberto Gallo, Alberto Russi, Francesco Lo Re, Susanna Ciampalini, Lucia Guidotti, Marta Serena, Angelo Claudio Palozzo
Riassunto. Obiettivi. Lo scopo di questo studio è stato valutare l'impatto della riconciliazione terapeutica nella pratica clinica dal punto di vista del farmacista ospedaliero. Metodi. È stata condotta un'indagine riguardante i trattamenti farmacologici assunti dai pazienti al momento dell'ammissione e della dimissione in un ospedale oncologico. Il farmacista ha inserito i dati raccolti in un supporto informatico che, impiegando i criteri di STOPP (Screening Tool of Older Persons' Potentially Inappropriate Prescriptions) e il database Micromedex™, utile per valutare le interazioni farmacologiche, ha prodotto automaticamente un report che indicava le possibili incongruenze farmacologiche...
March 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28388299/innovation-analysis-on-postgenomic-biomarkers-glycomics-for-chronic-diseases
#9
Eric Adua, Alyce Russell, Peter Roberts, Youxin Wang, Manshu Song, Wei Wang
Despite decades of investment in biomarker research, we still do not have robust and field-tested biomarkers for many chronic diseases so as to anticipate clinical outcomes and thus move toward personalized medicine. Biomarker innovations have tended to focus on genomics, but next-generation biomarkers from the nascent field of glycomics now offer fresh vistas for innovation in chronic disease biomarkers and systems diagnostics. Glycosylation, regarded as a complex enzymatic process where sugars (glycans) bind to proteins and lipids, affects many human biological functions, including cell signaling, adhesion, and motility...
April 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28384618/microwave-dielectric-spectroscopy-study-of-water-dynamics-in-normal-and-contaminated-raw-bovine-milk
#10
Daniel Agranovich, Paul Ben Ishai, Gil Katz, Dror Bezman, Yuri Feldman
The role of water in bovine milk is more complicated than that of a background solvent. To understand the interaction between water and the constituents of milk, an extensive dielectric study of the γ-dispersion of raw bovine milk was carried out over the frequency range 0.1-50GHz and the interval of temperatures (10°C-42°C). Samples were provided by utilizing an extended donor pool. The results reveal that the temperature dependence of the characteristic relaxation times is described by the Arrhenius law...
March 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28380468/orthodontic-traction-of-impacted-upper-canines-using-the-vista-technique
#11
Rita Catia Bras Bariani, Rodrigo Milani, Carlos H Guimaraes Junior, Wilana S Moura, Cristina Lucia Feijo Ortolani
No abstract text is available yet for this article.
February 2017: Journal of Clinical Orthodontics: JCO
https://www.readbyqxmd.com/read/28377153/clinical-performance-of-cardiac-troponin-i-a-comparison-between-the-poct-aqt90-flex-and-the-dimension-vista-analyzer-in-an-emergency-setting
#12
Monica Maria Mion, Giada Bragato, Alessandra Casarotti, Chiara Cosma, Stefania Vigolo, Gianna Vettore, Franco Tosato, Martina Zaninotto, Mario Plebani
BACKGROUND: Cardiac troponin [cTn (I or T)] is the preferred biomarker for the diagnosis of myocardial infarction (MI). AIM: We studied the analytical performance of the POCT AQT90 FLEX cTnI assay and its diagnostic accuracy, in comparison to the Dimension Vista cTnI method, in patients presenting to the Emergency Department (ED) with suspect of acute coronary syndrome (ACS). METHODS: 786 consecutive patients were enrolled. cTnI was measured at admission to the ED and about 3 and 6 hours later...
April 1, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28373077/new-vistas-on-cannabis-use-disorder
#13
REVIEW
Miriam Melis, Roberto Frau, Peter W Kalivas, Sade Spencer, Vivian Chioma, Erica Zamberletti, Tiziana Rubino, Daniela Parolaro
Cannabis sativa preparations are the most consumed illicit drugs for recreational purposes worldwide, and the number of people seeking treatment for cannabis use disorder has dramatically increased in the last decades. Due to the recent decriminalization or legalization of cannabis use in the Western Countries, we may predict that the number of people suffering from cannabis use disorder will increase. Despite the increasing number of cannabis studies over the past two decades, we have gaps of scientific knowledge pertaining to the neurobiological consequences of long-term cannabis use...
March 31, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28368577/classics-in-chemical-neuroscience-aripiprazole
#14
Austen B Casey, Clinton E Canal
Aripiprazole was the first antipsychotic developed to possess agonist properties at dopamine D2 autoreceptors, a groundbreaking strategy that presented a new vista for schizophrenia drug discovery. The dopamine D2 receptor is the crucial target of all extant antipsychotics, and all developed prior to aripiprazole were D2 receptor antagonists. Extensive blockade of these receptors, however, typically produces extrapyramidal (movement) side effects, which plagued first-generation antipsychotics, such as haloperidol...
April 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28364571/3d-multislice-and-cone-beam-computed-tomography-systems-for-dental-identification
#15
REVIEW
Hana Eliášová, Taťjana Dostálová
3D Multislice and Cone-beam computed tomography (CBCT) in forensic odontology has been shown to be useful not only in terms of one or a few of dead bodies but also in multiple fatality incidents. 3D Multislice and Cone-beam computed tomography and digital radiography were demonstrated in a forensic examination form. 3D images of the skull and teeth were analysed and validated for long ante mortem/post mortem intervals. The image acquisition was instantaneous; the images were able to be optically enlarged, measured, superimposed and compared prima vista or using special software and exported as a file...
2017: Prague Medical Report
https://www.readbyqxmd.com/read/28364186/effect-of-nerve-growth-factor-on-neural-differentiation-of-mouse-embryonic-stem-cells
#16
S A Antonov, E S Manuilova, O V Dolotov, A G Kobylyansky, D R Safina, I A Grivennikov
The cholinergic, GABAergic, and catecholaminergic neurons derived from mouse embryonic stem cells in a culture medium supplemented with recombinant NGF were phenotyped and scored. NGF stimulated generation of neurons, but not neuronal progenitors from embryonic stem cells and affected the proportion of specific types of neurons in cultures of differentiating embryonic stem cells. These findings open vista to employ NGF for generation of specific neuron types from embryonic stem cells for fundamental and toxicological studies...
March 31, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28363835/functional-dynamics-of-hippocampal-glutamate-during-associative-learning-assessed-with-in-vivo-1-h-functional-magnetic-resonance-spectroscopy
#17
Jeffrey A Stanley, Ashley Burgess, Dalal Khatib, Karthik Ramaseshan, Muzamil Arshad, Helen Wu, Vaibhav A Diwadkar
fMRI has provided vibrant characterization of regional and network responses associated with associative learning and memory; however, their relationship to functional neurochemistry is unclear. Here, we introduce a novel application of in vivo proton functional magnetic resonance spectroscopy ((1)H fMRS) to investigate the dynamics of hippocampal glutamate during paired-associated learning and memory in healthy young adults. We show that the temporal dynamics of glutamate differed significantly during processes of memory consolidation and retrieval...
March 29, 2017: NeuroImage
https://www.readbyqxmd.com/read/28346412/vista-is-an-inhibitory-immune-checkpoint-that-is-increased-after-ipilimumab-therapy-in-patients-with-prostate-cancer
#18
Jianjun Gao, John F Ward, Curtis A Pettaway, Lewis Z Shi, Sumit K Subudhi, Luis M Vence, Hao Zhao, Jianfeng Chen, Hong Chen, Eleni Efstathiou, Patricia Troncoso, James P Allison, Christopher J Logothetis, Ignacio I Wistuba, Manuel A Sepulveda, Jingjing Sun, Jennifer Wargo, Jorge Blando, Padmanee Sharma
To date, anti-CTLA-4 (ipilimumab) or anti-PD-1 (nivolumab) monotherapy has not been demonstrated to be of substantial clinical benefit in patients with prostate cancer. To identify additional immune-inhibitory pathways in the prostate-tumor microenvironment, we evaluated untreated and ipilimumab-treated tumors from patients in a presurgical clinical trial. Levels of the PD-L1 and VISTA inhibitory molecules increased on independent subsets of macrophages in treated tumors. Our data suggest that VISTA represents another compensatory inhibitory pathway in prostate tumors after ipilimumab therapy...
March 27, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28339617/searching-for-the-smoker-s-paradox-in-acute-stroke-patients-treated-with-intravenous-thrombolysis
#19
Haitham M Hussein, Nicki Niemann, Emily D Parker, Adnan I Qureshi
Background: Inconsistent evidence supports better outcome in smokers after stroke. Our study examines this association in a large sample of ischemic stroke treated with intravenous thrombolysis. Method: Virtual International Stroke Trials Archive (VISTA) database, composed of individual patient data of multiple clinical trials, was queried. The primary outcome was functional independence at 3 months noted by modified Rankin Scale (mRS; a 7-point scale ranging from 0 [no deficit] to 6 [death]) score≤ 2...
January 28, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28336784/evaluation-of-the-effect-of-fingolimod-treatment-on-microglial-activation-using-serial-pet-imaging-in-multiple-sclerosis
#20
Marcus Sucksdorff, Eero Rissanen, Jouni Tuisku, Salla Nuutinen, Teemu Paavilainen, Johanna Rokka, Juha Rinne, Laura Airas
Traditionally, multiple sclerosis (MS) has been considered a white matter (WM) disease with focal inflammatory lesions. It is, however, becoming clear that significant pathology, such as microglial activation, also takes place outside the plaque areas, i.e. in areas of normal appearing white matter (NAWM) and gray matter (GM). Microglial activation can be detected in vivo using an 18 kDa translocator protein (TSPO) binding radioligands and positron emission tomography (PET). It is unknown whether fingolimod affects microglial activation in MS...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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