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https://www.readbyqxmd.com/read/29684348/crystal-structure-of-a-thermophilic-o-6-alkylguanine-dna-alkyltransferase-derived-self-labeling-protein-tag-in-covalent-complex-with-a-fluorescent-probe
#1
Franca Rossi, Castrese Morrone, Alberto Massarotti, Davide Maria Ferraris, Anna Valenti, Giuseppe Perugino, Riccardo Miggiano
The self-labeling protein tags are robust and versatile tools for studying different molecular aspects of cell biology. In order to be suitable for a wide spectrum of experimental conditions, it is mandatory that these systems are stable after the fluorescent labeling reaction and do not alter the properties of the fusion partner. SsOGT-H5 is an engineered variant alkylguanine-DNA-alkyl-transferase (OGT) of the hyperthermophilic archaeon Sulfolobus solfataricus, and it represents an alternative solution to the SNAP-tag® technology under harsh reaction conditions...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678842/biotin-at-high-concentration-interferes-with-the-loci-digoxin-assay-but-the-petinia-phenytoin-assay-is-not-affected
#2
Joe J Rodriguez, Fernando Acosta, Lavern Bourgeois, Amitava Dasgupta
Many automated immunoassays incorporate biotinylated antibodies and streptavidin-coated magnetic beads in the assay design. Biotin at elevated concentrations may interfere with these immunoassays. We evaluated potential interference of biotin on serum digoxin (LOCI assay utilizing biotinylated antibody) and phenytoin (PETINIA assay; no biotinylated antibody) measurements using the Vista 1500 analyzer. Aliquots of drug-free serum pool were supplemented with various biotin concentrations (range: 1 ng/mL to 250 ng/mL) followed by measuring apparent digoxin and phenytoin levels using appropriate immunoassays...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29676169/thirty-minutes-of-running-exercise-decreases-t2-signal-intensity-but-not-thickness-of-the-knee-joint-cartilage-a-3-0-t-magnetic-resonance-imaging-study
#3
Yiğitcan Karanfil, Naila Babayeva, Gürhan Dönmez, H Barış Diren, Muzaffer Eryılmaz, Mahmut Nedim Doral, Feza Korkusuz
Objective Recent studies showed a potential of magnetic resonance imaging (MRI), which can be used as an additional tool for diagnosing cartilage degeneration in the early stage. We designed a cross-sectional study in order to evaluate knee joint cartilage adaptation to running, using 3.0-T MRI equipped with the 3-dimensional turbo spin echo (VISTA = Volume ISotropic Turbo spin echo Acquisition) software. By this thickness (mm) and signal intensity (mean pixel value) can be quantified, which could be closely related to the fluid content of the knee joint cartilage, before and after running...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29673722/density-spectral-array-of-bis-vista%C3%A2-monitoring-system-in-a-functional-hemispherectomy
#4
C Luis, E Vilà, L Moltó, A Pardo, J L Fernández Candila, S Pacreu
We present the case of an adult patient with drug-resistant epilepsy caused by extensive inflammation in the right cerebral hemisphere. She was scheduled to undergo right functional hemispherectomy, which is common in pediatric surgery, but about which few studies have been published with respect to adult patients. During the intraoperative period, the density spectral array of the bilateral bispectral index (BIS) VISTATM monitoring system was used. We observed a power increase in low frequency (0.1-4Hz) and alpha bands (8-12Hz) in the right hemisphere, where the epileptogenic focus was...
April 16, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29629341/role-of-curcumin-in-disease-prevention-and-treatment
#5
REVIEW
Arshad Husain Rahmani, Mohammed A Alsahli, Salah M Aly, Masood A Khan, Yousef H Aldebasi
Treatment based on traditional medicine is very popular in developing world due to inexpensive properties. Nowadays, several types of preparations based on medicinal plants at different dose have been extensively recognized in the diseases prevention and treatment. In this vista, latest findings support the effect of Curcuma longa and its chief constituents curcumin in a broad range of diseases cure via modulation of physiological and biochemical process. In addition, various studies based on animal mode and clinical trials showed that curcumin does not cause any adverse complications on liver and kidney function and it is safe at high dose...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29590225/periodontal-regenerative-treatment-of-intrabony-defects-in-the-esthetic-zone-using-modified-vestibular-incision-subperiosteal-tunnel-access-m-vista
#6
Babak Najafi, Parisa Kheirieh, Alireza Torabi, Emil G Cappetta
Periodontal regenerative treatment of intrabony defects in the esthetic zone often poses a significant challenge to clinicians. Various materials and techniques have been proposed to achieve periodontal regeneration. This article presents modified vestibular incision subperiosteal tunnel access (M-VISTA) for treatment of intrabony defects in the esthetic zone. Two cases were treated using the proposed approach with enamel matrix derivatives and demineralized freeze-dried bone allograft to optimize the regenerative outcomes without affecting the soft tissue profile in the esthetic zone...
March 28, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29582108/underestimation-of-large-distances-in-active-and-passive-locomotion
#7
Heiko Hecht, Max Ramdohr, Christoph von Castell
Our ability to estimate distances, be it verbally or by locomotion, is exquisite at close range (action space). At distances above 100 m (vista space), verbal estimates continue to be quite accurate, whereas locomotor estimates have been found to be grossly underestimated. Until now, however, the latter have been performed on a treadmill, which might not translate to real-world walking. We investigated if the motor underestimation found on the treadmill holds up in a natural environment. Observers viewed pictures of objects at distances between 10 and 245 m and were asked to reproduce these distances in a blindfolded walking task (using passive movement or an active production method)...
March 26, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29577695/-enhancer-trapping-nearby-rps26-gene-in-zebrafish-mediated-by-the-tol2-transposon-and-it-s-annotation
#8
Yatong Sang, Dan Shen, Wei Chen, Shuheng Chan, Hao Gu, Bo Gao, Chengyi Song
With the completion of large-scale genome sequencing of human beings and other organisms, understanding the expression of control elements on the genome has become an important research task in the post-genome era. The enhancer trapping technology is an effective method for identifying enhancer elements in the genome and understanding its mechanism for gene expression regulation. In this study, we selected the stable enhancer trapping line TK4 (head and trunk specific GFP expression), which is generated with the mediation of Tol2 transposon system, and analyzed the trapped enhancers with the techniques of Splinkerette PCR (sp-PCR), in situ hybridization and comparative genomics...
March 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29561332/abstracts-presented-at-the-20th-joint-meeting-of-the-international-society-of-dermatopathology-march-1-2-2017-hilton-orlando-lake-buena-vista-in-the-walt-disney-world-resort-lake-buena-vista-florida-usa-erratum
#9
https://www.readbyqxmd.com/read/29550951/stone-tool-use-by-wild-capuchin-monkeys-sapajus-libidinosus-at-serra-das-confus%C3%A3%C2%B5es-national-park-brazil
#10
Tiago Falótico, Paulo Henrique M Coutinho, Carolina Q Bueno, Henrique P Rufo, Eduardo B Ottoni
Capuchin monkeys (Sapajus spp.) are proficient tool users, and the use of stone tools occurs in several populations, mostly to crack open encased foods. Two well-studied Brazilian populations of Sapajus libidinosus inhabit Fazenda Boa Vista and Serra da Capivara National Park and present different behavioral sets regarding tool use. Serra das Confusões National Park (SCoNP) lies between those sites, but little is known about the capuchin monkey population that lives there. To begin unraveling the capuchin behavior in this area, we conducted a brief survey for tool use sites...
March 17, 2018: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/29544515/next-generation-of-immune-checkpoint-therapy-in-cancer-new-developments-and-challenges
#11
REVIEW
Julian A Marin-Acevedo, Bhagirathbhai Dholaria, Aixa E Soyano, Keith L Knutson, Saranya Chumsri, Yanyan Lou
Immune checkpoints consist of inhibitory and stimulatory pathways that maintain self-tolerance and assist with immune response. In cancer, immune checkpoint pathways are often activated to inhibit the nascent anti-tumor immune response. Immune checkpoint therapies act by blocking or stimulating these pathways and enhance the body's immunological activity against tumors. Cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1(PD-L1) are the most widely studied and recognized inhibitory checkpoint pathways...
March 15, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29538501/-leprosy-trends-in-children-under-15-years-of-age-in-brazil-2001-2016
#12
Priscila Barros Schneider, Bruna Hinnah Borges Martins de Freitas
The aim of this study was to analyze trends in the detection rate of leprosy in children under 15 years of age in Brazil from 2001 to 2016. A time series study used the Prais-Winsten procedure for generalized linear regression analysis, with significance set at 5%. The mean detection rate was 5.77 per 100,000 inhabitants. However, a downward trend was observed in this rate, with an annual percent change (APC) of -5% (95%CI: -6.7; -3.3). There was a downward trend in all regions of Brazil. Among the regions, the North maintained a hyperendemic mean detection rate (≥ 10...
March 12, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29536387/validation-of-fluorescence-devices-for-evaluation-of-white-spot-lesions-in-orthodontic-patients
#13
K Kavvadia, K Seremidi, C Reppa, M Makou, P Lagouvardos
AIM: To clinically validate the fluorescence devices, DIAGNOdent Pen™ and Vista Proof™ for the evaluation of non-cavitated white spot lesions (WSL) in orthodontic patients and using direct visual examination after the brackets removal, as the gold standard. METHODS: The sample consisted of 31 patients, 13-28 years old, under fixed appliance orthodontic treatment. Teeth (N = 619) were evaluated with the brackets on, after cleaning and air drying, by direct, indirect visual examination and using the DIAGNOdent Pen™ device...
March 13, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29526824/immunohistochemical-and-image-analysis-based-study-demonstrate-that-several-immune-checkpoints-are-co-expressed-in-non-small-cell-lung-carcinoma-tumors
#14
Edwin Roger Parra, Pamela Villalobos, Jiexin Zhang, Carmen Behrens, Barbara Mino, Stephen Swisher, Boris Sepesi, Annika Weissferdt, Neda Kalhor, John Victor Heymach, Cesar Moran, Jianjun Zhang, Jack Lee, Jaime Rodriguez-Canales, Don Gibbons, Ignacio Ivan Wistuba
BACKGROUND: The understanding of immune checkpoint molecules' co-expression in non-small cell lung carcinoma (NSCLC) is important to potentially design combinatorial immunotherapy approaches. MATERIAL AND METHODS: We studied 225 formalin-fixed, paraffin-embedded tumor tissues from stage I-III NSCLCs-142 adenocarcinomas (ADCs) and 83 squamous cell carcinomas (SCCs)-placed in tissue microarrays. Nine immune checkpoint markers were evaluated; 4 (PD-L1, B7-H3, B7-H4, and IDO-1) expressed predominantly in malignant cells (MCs) and 5 (ICOS, VISTA, TIM3, LAG3, and OX40) expressed mostly in stromal tumor-associated inflammatory cells (TAICs)...
March 8, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29520483/immune-cell-landscape-in-therapy-na%C3%A3-ve-squamous-cell-and-adenocarcinomas-of-the-lung
#15
Luka Brcic, Stefanie Stanzer, Dagmar Krenbek, Ulrike Gruber-Moesenbacher, Gudrun Absenger, Franz Quehenberger, Arschang Valipour, Joerg Lindenmann, Herbert Stoeger, Mohamed Al Effah, Melanie Fediuk, Marija Balic, Helmut H Popper
Squamous cell and adenocarcinomas of the lung develop different mechanisms during carcinogenesis to evade attacks of the immune system. Besides the well-known check-point control programmed death 1 and its ligand, many more mechanisms, acting either tumoricidal or in favor of tumor progression, exist. Analysis of the immune cell profiles in resected tissues and bronchoalveolar lavage samples and correlation between them and with overall survival data was performed. In all tumor samples in this study, cells of the immune system expressed a tumor-cooperating phenotype...
March 8, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29514927/a-vcp-inhibitor-substrate-trapping-approach-vista-enables-proteomic-profiling-of-endogenous-erad-substrates
#16
Edmond Y Huang, Milton To, Erica Tran, Lorraine T Ador Dionisio, Hyejin J Cho, Katherine L M Baney, Camille I Pataki, James A Olzmann
Endoplasmic reticulum (ER)-associated degradation (ERAD) mediates the proteasomal clearance of proteins from the early secretory pathway. In this process, ubiquitinated substrates are extracted from membrane-embedded dislocation complexes by the AAA ATPase VCP and targeted to the cytosolic 26S proteasome. In addition to its well-established role in the degradation of misfolded proteins, ERAD also regulates the abundance of key proteins such as enzymes involved in cholesterol synthesis. However, due to the lack of generalizable methods, our understanding of the scope of proteins targeted by ERAD remains limited...
March 7, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29512239/the-changing-vista-of-pleural-effusion-management-indwelling-pleural-catheters-ipc
#17
Sarah Jane Messeder, Mahendran Chetty, Megan C Thomson, Graeme P Currie
No abstract text is available yet for this article.
March 7, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29497089/author-correction-immune-checkpoint-protein-vista-critically-regulates-the-il-23-il-17-inflammatory-axis
#18
Na Li, Wenwen Xu, Ying Yuan, Natarajan Ayithan, Yasutomo Imai, Xuesong Wu, Halli Miller, Michael Olson, Yunfeng Feng, Yina H Huang, Mary Jo Turk, Samuel T Hwang, Subramaniam Malarkannan, Li Wang
A correction has been published and is linked to the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29495044/-head-neck-mri-what-ent-specialists-should-know
#19
Gerlig Widmann
Magnetic resonance imaging (MRI) has become an important imaging technique for otorhinolaryngology. The aim of the present CME contribution for ENT physicians is to provide an overview of the advantages and disadvantages as well as the possibilities of head and neck MRI and to summarize the main clinical applications of the various MRI sequences. Basic sequences (T1w, T2w, T1wC+) and fat suppression sequences (TIRM/STIR, Dixon, Spectral Fat sat) are the basis for evaluating inflammation, congenital lesions and tumors...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29484121/novel-mutational-landscapes-and-expression-signatures-of-lung-squamous-cell-carcinoma
#20
Donghai Xiong, Jing Pan, Yuxin Yin, Hui Jiang, Eva Szabo, Ronald A Lubet, Yian Wang, Ming You
Lung squamous cell carcinoma (LUSC) is a major subtype of Non-Small Cell Lung Cancer. To increase our understanding of the LUSC pathobiology, we performed exome sequencing and RNA-seq in 16 murine carcinogen-induced LUSC tumors and 8 normal murine lung tissue samples. Additionally, we conducted single-cell RNA-seq on two independent tumors from the same murine model. We identified a list of 59 cancer genes recurrently mutated in the mice LUSC tumors, 47 (80%) of which were also mutated in human LUSCs. At the single cell level, we detected unique clonal mutation patterns for each of the two LUSC tumors, being initiated from clones carrying the mutant Igfbp7 and Trp53 genes, respectively...
January 26, 2018: Oncotarget
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