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https://www.readbyqxmd.com/read/28814412/long-term-outcomes-with-as-needed-aflibercept-in-diabetic-macular-oedema-2-year-outcomes-of-the-endurance-extension-study
#1
Charles C Wykoff, William C Ou, Rahul N Khurana, David M Brown, W Lloyd Clark, David S Boyer
BACKGROUND/AIMS: To evaluate the efficacy and safety of individualised 2.0 mg intravitreal aflibercept retreatment for diabetic macular oedema (DME) through the fifth year of management. METHODS: This is a phase IV, 2-year, open-label extension study. Sixty patients completing the 3-year VISTA DME (Study of Intravitreal Aflibercept Injection in Patients With Diabetic Macular Edema) phase III trial enrolled in the ENDURANCE (Long-Term Efficacy and Safety of Intravitreal Aflibercept for the Treatment of DME in Subjects Who Completed the VISTA DME Trial) extension study...
August 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28803962/post-analytical-stability-of-23-common-chemistry-and-immunochemistry-analytes-in-incurred-samples
#2
Betina Klint Nielsen, Tina Frederiksen, Lennart Friis-Hansen, Pia Bükmann Larsen
BACKGROUND: Storage of blood samples after centrifugation, decapping and initial sampling allows ordering of additional blood tests. The pre-analytic stability of biochemistry and immunochemistry analytes has been studied in detail, but little is known about the post-analytical stability in incurred samples. METHODS: We examined the stability of 23 routine analytes on the Dimension Vista® (Siemens Healthineers, Denmark): 42-60 routine samples in lithium-heparin gel tubes (Vacutainer, BD, USA) were centrifuged at 3000×g for 10min...
August 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28794250/validating-and-comparing-stroke-prognosis-scales
#3
Terence J Quinn, Sarjit Singh, Kennedy R Lees, Philip M Bath, Phyo K Myint
OBJECTIVE: To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS: We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute Stroke Registry and Analysis of Lausanne [ASTRAL]; iSCORE; iSCORE-revised; preadmission comorbidities, level of consciousness, age, and neurologic deficit [PLAN]; stroke subtype, Oxfordshire Community Stroke Project, age, and prestroke modified Rankin Scale [mRS] [SOAR]; modified SOAR; Stroke Prognosis Instrument 2 [SPI2]; and Totaled Health Risks in Vascular Events [THRIVE]) using individual patient-level data from a clinical trials archive (Virtual International Stroke Trials Archive [VISTA])...
August 9, 2017: Neurology
https://www.readbyqxmd.com/read/28776578/negative-immune-checkpoint-regulation-by-vista-a-mechanism-of-acquired-resistance-to-anti-pd-1-therapy-in-metastatic-melanoma-patients
#4
Hojabr Kakavand, Louise A Jackett, Alexander M Menzies, Tuba N Gide, Matteo S Carlino, Robyn P M Saw, John F Thompson, James S Wilmott, Georgina V Long, Richard A Scolyer
Understanding the mechanisms of acquired resistance to anti-PD-1 will allow development of better treatment strategies for cancer patients. This study evaluated potential mechanisms of acquired resistance to anti-PD-1 in longitudinally collected metastatic melanoma patient biopsies. Thirty-four metastatic melanoma biopsies were collected from 16 patients who had initially responded to either anti-PD-1 (n=13) alone or combination of anti-PD-1 and ipilimumab (n=3) and then progressed. Biopsies were taken prior to treatment (PRE, n=12) and following progression of disease (PROG, n=22)...
August 4, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28774584/ictal-cardiac-activity-towards-a-wider-dynamical-vista
#5
EDITORIAL
Ivan Osorio
No abstract text is available yet for this article.
July 18, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28767925/autism-spectrum-disorders-an-updated-guide-for-genetic-counseling
#6
Karina Griesi-Oliveira, Andréa Laurato Sertié
Autism spectrum disorder is a complex and genetically heterogeneous disorder, which has hampered the identification of the etiological factors in each patient and, consequently, the genetic counseling for families at risk. However, in the last decades, the remarkable advances in the knowledge of genetic aspects of autism based on genetic and molecular research, as well as the development of new molecular diagnostic tools, have substantially changed this scenario. Nowadays, it is estimated that using the currently available molecular tests, a potential underlying genetic cause can be identified in nearly 25% of cases...
April 2017: Einstein
https://www.readbyqxmd.com/read/28764888/baseline-factors-affecting-changes-in-diabetic-retinopathy-severity-scale-score-after-intravitreal-aflibercept-or-laser-for-diabetic-macular-edema-post-hoc-analyses-from-vista-and-vivid
#7
Dilsher S Dhoot, Keith Baker, Namrata Saroj, Robert Vitti, Alyson J Berliner, Carola Metzig, Desmond Thompson, Rishi P Singh
PURPOSE: To evaluate whether select baseline systemic and ocular factors influence ≥2-step improvement in the Diabetic Retinopathy Severity Scale (DRSS) score at week 100 in VISTA and VIVID. DESIGN: Post hoc analysis of 2 similarly designed phase 3 trials, VISTA and VIVID. PARTICIPANTS: Total of 456 patients with center-involved diabetic macular edema (DME). METHODS: VISTA and VIVID randomized 872 DME patients to receive intravitreal aflibercept injection (IAI) 2 mg every 4 weeks (2q4), IAI 2 mg every 8 weeks after 5 monthly doses (2q8), or macular laser photocoagulation...
July 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28761757/mechanisms-of-action-and-rationale-for-the-use-of-checkpoint-inhibitors-in-cancer
#8
REVIEW
Clemence Granier, Eleonore De Guillebon, Charlotte Blanc, Helene Roussel, Cecile Badoual, Elia Colin, Antonin Saldmann, Alain Gey, Stephane Oudard, Eric Tartour
The large family of costimulatory molecules plays a crucial role in regulation of the immune response. These molecules modulate TCR signalling via phosphorylation cascades. Some of the coinhibitory members of this family, such as PD-1 and CTLA-4, already constitute approved targets in cancer therapy and, since 2011, have opened a new area of antitumour immunotherapy. Many antibodies targeting other inhibitory receptors (Tim-3, VISTA, Lag-3 and so on) or activating costimulatory molecules (OX40, GITR and so on) are under evaluation...
2017: ESMO Open
https://www.readbyqxmd.com/read/28753305/mimicking-a-natural-enzyme-system-cytochrome-c-oxidase-like-activity-of-cu2o-nanoparticles-by-receiving-electrons-from-cytochrome-c
#9
Ming Chen, Zhonghua Wang, Jinxia Shu, Xiaohui Jiang, Wei Wang, Zhen-Hua Shi, Ying-Wu Lin
Inorganic nanomaterials-based artificial enzymes (nanozymes) have received considerable attention over the past years. However, the substrates studied for nanozymes have so far been limited to small organic molecules. The catalytic oxidation of biomacromolecules, such as proteins, by nanozymes has not yet been reported to date. In this study, we report that cuprous oxide nanoparticles (Cu2O NPs) possess cytochrome c oxidase (CcO)-like activity and catalyze the oxidation of cytochrome c (Cyt c), converting it from the ferrous state to the ferric state under atmospheric oxygen conditions...
July 28, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28734301/communication-influence-of-external-static-and-alternating-electric-fields-on-water-from-long-time-non-equilibrium-ab-initio-molecular-dynamics
#10
Zdenek Futera, Niall J English
The response of water to externally applied electric fields is of central relevance in the modern world, where many extraneous electric fields are ubiquitous. Historically, the application of external fields in non-equilibrium molecular dynamics has been restricted, by and large, to relatively inexpensive, more or less sophisticated, empirical models. Here, we report long-time non-equilibrium ab initio molecular dynamics in both static and oscillating (time-dependent) external electric fields, therefore opening up a new vista in rigorous studies of electric-field effects on dynamical systems with the full arsenal of electronic-structure methods...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28726904/vesicle-aggregates-as-a-model-for-primitive-cellular-assemblies
#11
Tereza Pereira de Souza, Guilherme Volpe Bossa, Pasquale Stano, Frank Steiniger, Sylvio May, Pier Luigi Luisi, Alfred Fahr
Primitive cell models help to understand the role that compartmentalization plays in origin of life scenarios. Here we present a combined experimental and modeling approach towards the construction of simple model systems for primitive cellular assemblies. Charged lipid vesicles aggregate in the presence of oppositely charged biopolymers, such as nucleic acids or polypeptides. Based on zeta potential measurements, dynamic light scattering and cryo-transmission electron-microscopy, we have characterized the behavior of empty and ferritin-filled large unilamellar POPC vesicles, doped with different amounts of cationic (DDAB, CTAB) and anionic (sodium oleate) surfactants, and their aggregation upon the addition of anionic (tRNA, poly-l-glutamic acid) and cationic (poly-l-arginine) biopolymers, respectively...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28704179/analytical-evaluation-of-the-new-beckman-coulter-access-high-sensitivity-cardiac-troponin-i-immunoassay
#12
Giuseppe Lippi, Anna Ferrari, Giorgio Gandini, Matteo Gelati, Claudia Lo Cascio, Gian Luca Salvagno
BACKGROUND: This study was aimed to evaluate the analytical performance of the novel chemiluminescent and fully-automated Beckman Coulter Access hsTnI high-sensitivity immunoassay for measurement of cardiac troponin I (cTnI). METHODS: The study, using lithium heparin samples, included assessment of limit of blank (LOB), limit of detection (LOD), functional sensitivity, linearity, imprecision (within run, between-run and total), calculation of 99th percentile upper reference limit (URL) in 175 healthy blood donors (mean age, 36±12 years; 47% women) and comparison with two other commercial cTnI immunoassays...
July 12, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28692416/immunoglobulin-g-n-glycans-as-potential-postgenomic-biomarkers-for-hypertension-in-the-kazakh-population
#13
Qing Gao, Mamatyusupu Dolikun, Jerko Štambuk, Hao Wang, Feifei Zhao, Nizam Yiliham, Youxin Wang, Irena Trbojević-Akmačić, Jie Zhang, Honghong Fang, Yang Sun, Hongli Peng, Zhongyao Zhao, Di Liu, Jiaonan Liu, Qihuan Li, Qi Sun, Lijuan Wu, Gordan Lauc, Wei Wang, Manshu Song
Next-generation (postgenomic) biomarkers from the nascent field of glycomics now offer fresh vistas for innovation in chronic disease biomarkers and system diagnostics in clinical medicine. Our previous work has shown an association between hypertension and immunoglobulin G (IgG) glycome composition, suggesting that individual variation in N-glycosylation of IgG might contribute to hypertension pathogenesis. The present study examined, for the first time to the best of our knowledge, the IgG N-glycans as potential biomarkers for hypertension in the Kazakh population...
July 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28680891/is-the-grafted-tendon-shifted-anteriorly-in-the-femoral-tunnel-at-the-postremodeling-phase-after-anterior-cruciate-ligament-reconstruction-a-clinical-mri-study
#14
Jun Onodera, Kazunori Yasuda, Tetsuro Masuda, Yoshie Tanabe, Nobuto Kitamura, Tomonori Yagi, Eiji Kondo
BACKGROUND: Based on previous in vitro studies, it has been commonly believed that during anterior cruciate ligament (ACL) reconstruction with hamstring tendon, the grafted tendon is shifted anteriorly in the tunnel permanently after the graft is anchored to the tunnel wall. However, this has not been proven by in vivo studies. HYPOTHESIS: At 1 year after anatomic double-bundle ACL reconstruction, the grafted tendons may not be shifted anteriorly in the femoral tunnel but anchored to the bony wall at the center of the tunnel...
June 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28678931/vascular-aging-and-arterial-stiffness
#15
Luana de Rezende Mikael, Anelise Machado Gomes de Paiva, Marco Mota Gomes, Ana Luiza Lima Sousa, Paulo César Brandão Veiga Jardim, Priscila Valverde de Oliveira Vitorino, Maicon Borges Euzébio, Wátila de Moura Sousa, Weimar Kunz Sebba Barroso
Cardiovascular diseases (CVD) account annually for almost one third of all deaths worldwide. Among the CVD, systemic arterial hypertension (SAH) is related to more than half of those outcomes. Type 2 diabetes mellitus is an independent risk factor for SAH because it causes functional and structural damage to the arterial wall, leading to stiffness. Several studies have related oxidative stress, production of free radicals, and neuroendocrine and genetic changes to the physiopathogenesis of vascular aging. Indirect ways to analyze that aging process have been widely studied, pulse wave velocity (PWV) being considered gold standard to assess arterial stiffness, because there is large epidemiological evidence of its predictive value for cardiovascular events, and it requires little technical knowledge to be performed...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28676029/cardiovascular-concern-of-5-ht2b-receptor-and-recent-vistas-in-the-development-of-its-antagonists
#16
Komal Padhariya, Richie R Bhandare, Daniel Canney, Vinay Velingkar
The serotonin 2B receptor subtype (5-HT2BR), located in central nervous system (CNS), cardiovascular system (CVS) and the gastrointestinal tract (GIT), is an important target for the treatment of migraine, obesity and irritable bowel syndrome. 5-HT2BR is necessary for the myocardial cell proliferation and differentiation at the embroyonic stage for healthy development of heart. Recently, its involvement in drug induced valvulopathy and other myocardial disorders have paved a way for selective antagonist for the treatment of cardiac disorders...
July 3, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28664413/molecular-profiling-of-sarcomas-new-vistas-for-precision-medicine
#17
Tariq Al-Zaid, Wei-Lien Wang, Neeta Somaiah, Alexander J Lazar
Sarcoma is a large and heterogeneous group of malignant mesenchymal neoplasms with significant histological overlap. Accurate diagnosis can be challenging yet important for selecting the appropriate treatment approach and prognosis. The currently torrid pace of new genomic discoveries aids our classification and diagnosis of sarcomas, understanding of pathogenesis, development of new medications, and identification of alterations that predict prognosis and response to therapy. Unfortunately, demonstrating effective targets for precision oncology has been elusive in most sarcoma types...
June 29, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28662558/integrating-point-of-care-ultrasonography-into-the-osteopathic-medical-school-curriculum
#18
Brian A Russ, Danika Evans, Daniel Morrad, Codee Champney, Ashley M Woodworth, Lane Thaut, Molly Thiessen
Point-of-care ultrasonography has been shown to have pervasive clinical and educational utility in medicine. The need to provide medical students with training in point-of-care ultrasonography has been recognized by an increasing number of osteopathic and allopathic medical schools. A 4-year integrated ultrasonography curriculum was implemented at Rocky Vista University College of Osteopathic Medicine in 2015. A review of the curriculum design, content, educational methods, and student feedback are described...
July 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28659048/blocking-the-vista-pathway-enhances-disease-progression-in-nzb%C3%A2-%C3%A3-%C3%A2-nzw-f1-female-mice
#19
P A Sergent, S F Plummer, J Pettus, R Mabaera, J K DeLong, D A Pechenick, C M Burns, R J Noelle, S Ceeraz
V-domain Ig suppressor of T-cell activation (VISTA) is a critical negative checkpoint molecule involved in regulating the immune response. Targeting the pathway with an antagonist anti-VISTA antibody designated 13F3 has been shown to enhance disease severity in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. To determine if VISTA plays a role in murine lupus, New Zealand Black × New Zealand White (BWF1) mice were treated with 13F3 or control hamster Ig and disease monitored...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28658342/robotic-transversus-abdominis-release-tar-is-it-possible-to-offer-minimally-invasive-surgery-for-abdominal-wall-complex-defects
#20
Maria Vitória França DO Amaral, José Ricardo Guimarães, Paula Volpe, Flávio Malcher Martins DE Oliveira, Carlos Eduardo Domene, Sérgio Roll, Leandro Totti Cavazzola
We describe the preliminary national experience and the early results of the use of robotic surgery to perform the posterior separation of abdominal wall components by the Transversus Abdominis Release (TAR) technique for the correction of complex defects of the abdominal wall. We performed the procedures between 04/2/2015 and 06/15/2015 and the follow-up time was up to six months, with a minimum of two months. The mean surgical time was five hours and 40 minutes. Two patients required laparoscopic re-intervention, since one developed hernia by peritoneal migration of the mesh and one had mesh extrusion...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
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