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https://www.readbyqxmd.com/read/29453537/toxicogenomics-a-new-paradigm-for-nanotoxicity-evaluation
#1
Sourabh Dwivedi, Quaiser Saquib, Bilal Ahmad, Sabiha M Ansari, Ameer Azam, Javed Musarrat
The wider applications of nanoparticles (NPs) has evoked a world-wide concern due to their possible risk of toxicity in humans and other organisms. Aggregation and accumulation of NPs into cell leads to their interaction with biological macromolecules including proteins, nucleic acids and cellular organelles, which eventually induce toxicological effects. Application of toxicogenomics to investigate molecular pathway-based toxicological consequences has opened new vistas in nanotoxicology research. Indeed, genomic approaches appeared as a new paradigm in terms of providing information at molecular levels and have been proven to be as a powerful tool for identification and quantification of global shifts in gene expression...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453446/environmental-genetic-and-epigenetic-contributions-to-cocaine-addiction
#2
REVIEW
R Christopher Pierce, Bruno Fant, Sarah E Swinford-Jackson, Elizabeth A Heller, Wade H Berrettini, Mathieu E Wimmer
Decades of research on cocaine has produced volumes of data that have answered many important questions about the nature of this highly addictive drug. Sadly, none of this information has translated into the development of effective therapies for the treatment of cocaine addiction. This review endeavors to assess the current state of cocaine research in an attempt to identify novel pathways for therapeutic development. For example, risk of cocaine addiction is highly heritable but genome-wide analyses comparing cocaine-dependent individuals to controls have not resulted in promising targets for drug development...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29447318/management-of-multiple-gingival-recessions-with-the-vista-technique-an-18-month-clinical-case-series
#3
Raja Rajeswari S, Tarun Ab Kumar, Triveni M Gowda, Dhoom S Mehta, Arun Kumar
The purpose of the present study was to evaluate the efficacy of the vestibular incision subperiosteal tunnel access (VISTA) technique with collagen membrane, bioactive glass, and platelet-rich fibrin. A total of 22 systemically and periodontally healthy subjects with multiple gingival recession defects (Miller Class I and II) in the maxillary esthetic zone were enrolled in the study. The primary outcome measures were mean root coverage and alteration in gingival thickness. There were no surgical complications; however, one patient reported swelling of the upper lip area on the first postoperative day, which resolved spontaneously...
March 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29430347/carica-papaya-papaya-latex-a-new-paradigm-to-combat-against-dengue-and-filariasis-vectors-aedes-aegypti-and-culex-quinquefasciatus-diptera-culicidae
#4
Rajkuberan Chandrasekaran, Prabukumar Seetharaman, Muthukumar Krishnan, Sathishkumar Gnanasekar, Sivaramakrishnan Sivaperumal
This study manifests the larvicidal efficacy of Carica papaya latex extract and silver nanoparticles (CPAgNPs) synthesized using latex, against developing immature juveniles of Aedes aegypti and Culex quinquefasciatus. Briefly, the latex was collected and fractioned with different solvents such as chloroform, methanol and aqueously. The obtained crude extracts were subjected to larvicidal activity in the dose-dependent method. After 24 h, the mortality rate was calculated and statistically analyzed. From the results, it was demonstrated that the chloroform extract displayed prominent activity in IInd and IIIrd instar larvae of A...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29427886/understanding-the-exfoliation-and-dispersion-of-mos2-nanosheets-in-pure-water
#5
Han Ma, Zhigang Shen, Shuang Ben
Exfoliation and dispersion of two dimensional (2D) transition metal dichacogenides (TMDCs) such as MoS2 in water are highly demanded. In this paper, we exfoliate MoS2 nanosheets in pure water via ultrasonication and attempt to understand the exfoliation process and the dispersion behavior of hydrophobic MoS2. Cavitation-induced exfoliation leads to thinning and fragmentation of MoS2 flakes. Formation of mesoporous MoS2 sheets suggests that the exfoliation initiates from the basal planes. As for the dispersion of MoS2 nanosheets in water, we find that higher centrifugation rate and thus smaller lateral size, results in improved stability...
November 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29406021/a-simple-vista-en-este-n%C3%A3%C2%BAmero
#6
Sandeep Ravindran
No abstract text is available yet for this article.
January 2018: Ophthalmology
https://www.readbyqxmd.com/read/29396936/flow-cytometry-in-pediatric-malignancies
#7
Anil Handoo, Tina Dadu
The utility of flow cytometry as a useful diagnostic modality for the assessment of hematopoietic neoplasms has been established beyond doubt. In fact, it is now an integral part of the diagnosis and classification of various diseases like leukemias and lymphomas along with molecular studies and cytogenetics. Prognostication and disease monitoring by flow cytometry is also being recognized increasingly as one of the important fortes. This is evident by the number of articles in the published in literature on the minimal residual disease detection by flow cytometry especially in the last decade or so...
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29391199/leishmanicidal-and-cytotoxic-activity-from-plants-used-in-tacana-traditional-medicine-bolivia
#8
Diandra Arévalo-Lopéz, Nélida Nina, Juan C Ticona, Ivan Limachi, Efrain Salamanca, Enrique Udaeta, Crispin Paredes, Boris Espinoza, Alcides Serato, David Garnica, Abigail Limachi, Dayana Coaquira, Sarah Salazar, Ninoska Flores, Olov Sterner, Alberto Giménez
ETNOPHARMACOLOGICAL RELEVANCE: thirty-eight Tacana medicinal plant species used to treat skin problems, including leishmania ulcers, skin infections, inflammation and wound healing, were collected in the community of Buena Vista, Bolivia, with the Tacana people. Twenty two species are documented for the first time as medicinal plants for this ethnic group living in the northern area of the Department of La Paz. AIM OF THE STUDY: To evaluate the leishmanicidal effect (IC50) and cytotoxicity (LD50) of the selected plants...
January 29, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29388254/wave-caipi-vista-highly-accelerated-whole-brain-direct-myelin-water-imaging-with-zero-padding-reconstruction
#9
Zhe Wu, Berkin Bilgic, Hongjian He, Qiqi Tong, Yi Sun, Yiping Du, Kawin Setsompop, Jianhui Zhong
PURPOSE: This study introduces a highly accelerated whole-brain direct visualization of short transverse relaxation time component (ViSTa) imaging using a wave controlled aliasing in parallel imaging (CAIPI) technique, for acquisition within a clinically acceptable scan time, with the preservation of high image quality and sufficient spatial resolution, and reduced residual point spread function artifacts. METHODS: Double inversion RF pulses were applied to preserve the signal from short T1 components for directly extracting myelin water signal in ViSTa imaging...
February 1, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29375120/the-structure-expression-and-multifaceted-role-of-immune-checkpoint-protein-vista-as-a-critical-regulator-of-anti-tumor-immunity-autoimmunity-and-inflammation
#10
REVIEW
Wenwen Xu, TạMinh Hiếu, Subramaniam Malarkannan, Li Wang
Among various immunoregulatory molecules, the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy. Antibodies targeting two B7 family co-inhibitory receptors, CTLA-4 and PD-1, have elicited long-term clinical outcomes in previously refractory cancer types and are considered a breakthrough in cancer therapy. Despite the success, the relatively low response rate (20-30%) warrants efforts to identify and overcome additional immune-suppressive pathways. Among the expanding list of T cell inhibitory regulators, V domain immunoglobulin suppressor of T cell activation (VISTA) is a unique B7 family checkpoint that regulates a broad spectrum of immune responses...
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29357455/non-sinusoidal-neuronal-oscillations-bug-or-feature
#11
Diego Lozano-Soldevilla
There is compiling evidence suggesting that independent neuronal ensembles are coordinated in time and space through cross-frequency coupling (CFC). However, recent studies have convincingly demonstrated that non-sinusoidal oscillations produce serious biases in state of the art CFC metrics. Although most of studies treat non-sinusoidal waves as a nuisance or just ignore them, fortunately, some scientists are starting to exploit their neurophysiological relevance opening new research vistas with critical implications...
January 3, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29340973/reference-intervals-for-thyrotropin-in-an-area-of-northern-italy-the-pordenone-thyroid-study-tripp
#12
R Tozzoli, F D'Aurizio, P Metus, A Steffan, C Mazzon, M Bagnasco
PURPOSE: Thyrotropin (TSH) is the most accurate marker of thyroid dysfunction in the absence of pituitary or hypothalamic disease. Studies on TSH reference intervals (RIs) showed wide inter-individual variability and prompted an intense debate about the best estimation of TSH RIs. DESIGN: We performed a population study on TSH RIs, using current data stored in the laboratory information system (LIS), at the Hospital Department of Laboratory Medicine, Pordenone (Italy), historically an area of mild-moderate iodine deficiency with a relatively high goiter prevalence...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29331587/il-23-il-17-immune-axis-in-guillain-barr%C3%A3-syndrome-exploring-newer-vistas-for-understanding-pathobiology-and-therapeutic-implications
#13
REVIEW
Monojit Debnath, Madhu Nagappa, Geetanjali Murari, Arun B Taly
Guillain Barré Syndrome (GBS) is a severe disorder of the peripheral nervous system with an inadequately known etiopathology. It is a post infectious immune mediated disorder, characterized by autoantibody production, complement activation as well as T reactivity against gangliosides. However, the precise etiopathogenesis remains poorly understood in a majority of the patients. Th17 cells, a recently identified lineage of Th cells have emerged as a predominant inducer of autoimmunity and inflammation in various immunological disorders...
January 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29324045/neuroparasitology-of-parasite-insect-associations
#14
David P Hughes, Frederic Libersat
Insect behavior can be manipulated by parasites, and in many cases, such manipulation involves the central and peripheral nervous system. Neuroparasitology is an emerging branch of biology that deals with parasites that can control the nervous system of their host. The diversity of parasites that can manipulate insect behavior ranges from viruses to macroscopic worms and also includes other insects that have evolved to become parasites (notably, parasitic wasps). It is remarkable that the precise manipulation observed does not require direct entry into the insect brain and can even occur when the parasite is outside the body...
January 7, 2018: Annual Review of Entomology
https://www.readbyqxmd.com/read/29310966/improving-the-anesthetic-process-by-a-fuzzy-rule-based-medical-decision-system
#15
Juan Albino Mendez, Ana Leon, Ayoze Marrero, Jose M Gonzalez-Cava, Jose Antonio Reboso, Jose Ignacio Estevez, José F Gomez-Gonzalez
OBJECTIVE: The main objective of this research is the design and implementation of a new fuzzy logic tool for automatic drug delivery in patients undergoing general anesthesia. The aim is to adjust the drug dose to the real patient needs using heuristic knowledge provided by clinicians. A two-level computer decision system is proposed. The idea is to release the clinician from routine tasks so that he can focus on other variables of the patient. METHODS: The controller uses the Bispectral Index (BIS) to assess the hypnotic state of the patient...
January 5, 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29303797/lack-of-early-improvement-predicts-poor-outcome-following-acute-intracerebral-hemorrhage
#16
Vignan Yogendrakumar, Eric E Smith, Andrew M Demchuk, Richard I Aviv, David Rodriguez-Luna, Carlos A Molina, Yolanda Silva Blas, Imanuel Dzialowski, Adam Kobayashi, Jean-Martin Boulanger, Cheemun Lum, Gord Gubitz, Vasantha Padma, Jayanta Roy, Carlos S Kase, Rohit Bhatia, Myzoon Ali, Patrick Lyden, Michael D Hill, Dar Dowlatshahi
OBJECTIVES: There are limited data as to what degree of early neurologic change best relates to outcome in acute intracerebral hemorrhage. We aimed to derive and validate a threshold for early postintracerebral hemorrhage change that best predicts 90-day outcomes. DESIGN: Derivation: retrospective analysis of collated clinical stroke trial data (Virtual International Stroke Trials Archive). VALIDATION: retrospective analysis of a prospective multicenter cohort study (Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign [PREDICT])...
January 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29303766/no-additional-value-of-conventional-and-high-sensitivity-cardiac-troponin-over-clinical-scoring-systems-in-the-differential-diagnosis-of-type-1-versus-type-2-myocardial-infarction
#17
Luciano Consuegra-Sánchez, Juan José Martínez-Díaz, Luis García de Guadiana-Romualdo, Samantha Wasniewski, Patricia Esteban-Torrella, Francisco Guillermo Clavel-Ruipérez, Alfredo Bardají, Juan Antonio Castillo-Moreno, Juan Carlos Kaski
BACKGROUND: The distinction of type 1 and type 2 myocardial infarction (MI) is of major clinical importance. Our aim was to evaluate the diagnostic ability of absolute and relative conventional cardiac troponin I (cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) in the distinction between type 1 and type 2 MI in patients presenting at the emergency department with non-ST-segment elevation acute chest pain within the first 12 h. METHODS: We measured cTnI (Dimension Vista) and hs-cTnT (Cobas e601) concentrations at presentation and after 4 h in 200 patients presenting with suspected acute MI...
January 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29297902/-la-combinazione-di-gemcitabina-e-oxaliplatino-gemox-nel-trattamento-del-carcinoma-pancreatico-in-fase-avanzata-di-malattia-le-notizie-sulla-mia-morte-sono-state-esagerate
#18
Jacopo Giuliani, Andrea Bonetti
Riassunto. L'analisi è stata condotta al fine di valutare l'effetto sia sulla sopravvivenza globale (OS) sia sulla sopravvivenza libera da progressione di malattia (PFS) della chemioterapia di combinazione in prima linea per il carcinoma pancreatico in fase avanzata di malattia. La presente analisi è limitata agli studi randomizzati controllati (RCT) di fase III. Successivamente è stata applicata la European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) agli RCT di fase III analizzati per ricavare uno score relativo all'entità del beneficio clinico ottenuto per ciascun RCT...
December 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29279367/cell-specific-and-region-specific-transcriptomics-in-the-multiple-sclerosis-model-focus-on-astrocytes
#19
Noriko Itoh, Yuichiro Itoh, Alessia Tassoni, Emily Ren, Max Kaito, Ai Ohno, Yan Ao, Vista Farkhondeh, Hadley Johnsonbaugh, Josh Burda, Michael V Sofroniew, Rhonda R Voskuhl
Changes in gene expression that occur across the central nervous system (CNS) during neurological diseases do not address the heterogeneity of cell types from one CNS region to another and are complicated by alterations in cellular composition during disease. Multiple sclerosis (MS) is multifocal by definition. Here, a cell-specific and region-specific transcriptomics approach was used to determine gene expression changes in astrocytes in the most widely used MS model, experimental autoimmune encephalomyelitis (EAE)...
January 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29260880/comparison-of-two-dimensional-fast-spin-echo-t2-weighted-sequences-and-three-dimensional-volume-isotropic-t2-weighted-fast-spin-echo-vista-mri-in-the-evaluation-of-triangular-fibrocartilage-of-the-wrist
#20
Hee Jin Park, So Yeon Lee, Kyung A Kang, Eun Young Kim, Hun Kyu Shin, Se Jin Park, Jai Hyung Park, Eugene Kim
OBJECTIVE: To compare image quality of three-dimensional volume isotropic T2-weighted fast spin-echo (3D VISTA) and 2D T2 weighted images (T2WI) for evaluation of triangular fibrocartilage (TFC) and to investigate whether 3D VISTA can replace 2D T2WI in evaluating TFC injury. METHODS: This retrospective study included 69 patients who received wrist MRIs using both 2D T2WI and 3D VISTA techniques for assessment of wrist pathology, including TFC injury. Two radiologists measured the signal-to-noise ratio (SNR) and the contrast-to-noise ratio (CNR) of the two sequences...
December 20, 2017: British Journal of Radiology
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