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https://www.readbyqxmd.com/read/28734301/communication-influence-of-external-static-and-alternating-electric-fields-on-water-from-long-time-non-equilibrium-ab-initio-molecular-dynamics
#1
Zdenek Futera, Niall J English
The response of water to externally applied electric fields is of central relevance in the modern world, where many extraneous electric fields are ubiquitous. Historically, the application of external fields in non-equilibrium molecular dynamics has been restricted, by and large, to relatively inexpensive, more or less sophisticated, empirical models. Here, we report long-time non-equilibrium ab initio molecular dynamics in both static and oscillating (time-dependent) external electric fields, therefore opening up a new vista in rigorous studies of electric-field effects on dynamical systems with the full arsenal of electronic-structure methods...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28726904/vesicle-aggregates-as-a-model-for-primitive-cellular-assemblies
#2
Tereza Pereira de Souza, Guilherme Volpe Bossa, Pasquale Stano, Frank Steiniger, Sylvio May, Pier Luigi Luisi, Alfred Fahr
Primitive cell models help to understand the role that compartmentalization plays in origin of life scenarios. Here we present a combined experimental and modeling approach towards the construction of simple model systems for primitive cellular assemblies. Charged lipid vesicles aggregate in the presence of oppositely charged biopolymers, such as nucleic acids or polypeptides. Based on zeta potential measurements, dynamic light scattering and cryo-transmission electron-microscopy, we have characterized the behavior of empty and ferritin-filled large unilamellar POPC vesicles, doped with different amounts of cationic (DDAB, CTAB) and anionic (sodium oleate) surfactants, and their aggregation upon the addition of anionic (tRNA, poly-l-glutamic acid) and cationic (poly-l-arginine) biopolymers, respectively...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28704179/analytical-evaluation-of-the-new-beckman-coulter-access-high-sensitivity-cardiac-troponin-i-immunoassay
#3
Giuseppe Lippi, Anna Ferrari, Giorgio Gandini, Matteo Gelati, Claudia Lo Cascio, Gian Luca Salvagno
BACKGROUND: This study was aimed to evaluate the analytical performance of the novel chemiluminescent and fully-automated Beckman Coulter Access hsTnI high-sensitivity immunoassay for measurement of cardiac troponin I (cTnI). METHODS: The study, using lithium heparin samples, included assessment of limit of blank (LOB), limit of detection (LOD), functional sensitivity, linearity, imprecision (within run, between-run and total), calculation of 99th percentile upper reference limit (URL) in 175 healthy blood donors (mean age, 36±12 years; 47% women) and comparison with two other commercial cTnI immunoassays...
July 12, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28692416/immunoglobulin-g-n-glycans-as-potential-postgenomic-biomarkers-for-hypertension-in-the-kazakh-population
#4
Qing Gao, Mamatyusupu Dolikun, Jerko Štambuk, Hao Wang, Feifei Zhao, Nizam Yiliham, Youxin Wang, Irena Trbojević-Akmačić, Jie Zhang, Honghong Fang, Yang Sun, Hongli Peng, Zhongyao Zhao, Di Liu, Jiaonan Liu, Qihuan Li, Qi Sun, Lijuan Wu, Gordan Lauc, Wei Wang, Manshu Song
Next-generation (postgenomic) biomarkers from the nascent field of glycomics now offer fresh vistas for innovation in chronic disease biomarkers and system diagnostics in clinical medicine. Our previous work has shown an association between hypertension and immunoglobulin G (IgG) glycome composition, suggesting that individual variation in N-glycosylation of IgG might contribute to hypertension pathogenesis. The present study examined, for the first time to the best of our knowledge, the IgG N-glycans as potential biomarkers for hypertension in the Kazakh population...
July 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28680891/is-the-grafted-tendon-shifted-anteriorly-in-the-femoral-tunnel-at-the-postremodeling-phase-after-anterior-cruciate-ligament-reconstruction-a-clinical-mri-study
#5
Jun Onodera, Kazunori Yasuda, Tetsuro Masuda, Yoshie Tanabe, Nobuto Kitamura, Tomonori Yagi, Eiji Kondo
BACKGROUND: Based on previous in vitro studies, it has been commonly believed that during anterior cruciate ligament (ACL) reconstruction with hamstring tendon, the grafted tendon is shifted anteriorly in the tunnel permanently after the graft is anchored to the tunnel wall. However, this has not been proven by in vivo studies. HYPOTHESIS: At 1 year after anatomic double-bundle ACL reconstruction, the grafted tendons may not be shifted anteriorly in the femoral tunnel but anchored to the bony wall at the center of the tunnel...
June 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28678931/vascular-aging-and-arterial-stiffness
#6
Luana de Rezende Mikael, Anelise Machado Gomes de Paiva, Marco Mota Gomes, Ana Luiza Lima Sousa, Paulo César Brandão Veiga Jardim, Priscila Valverde de Oliveira Vitorino, Maicon Borges Euzébio, Wátila de Moura Sousa, Weimar Kunz Sebba Barroso
Cardiovascular diseases (CVD) account annually for almost one third of all deaths worldwide. Among the CVD, systemic arterial hypertension (SAH) is related to more than half of those outcomes. Type 2 diabetes mellitus is an independent risk factor for SAH because it causes functional and structural damage to the arterial wall, leading to stiffness. Several studies have related oxidative stress, production of free radicals, and neuroendocrine and genetic changes to the physiopathogenesis of vascular aging. Indirect ways to analyze that aging process have been widely studied, pulse wave velocity (PWV) being considered gold standard to assess arterial stiffness, because there is large epidemiological evidence of its predictive value for cardiovascular events, and it requires little technical knowledge to be performed...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28676029/cardiovascular-concern-of-5-ht2b-receptor-and-recent-vistas-in-the-development-of-its-antagonists
#7
Komal Padhariya, Richie R Bhandare, Daniel Canney, Vinay Velingkar
The serotonin 2B receptor subtype (5-HT2BR), located in central nervous system (CNS), cardiovascular system (CVS) and the gastrointestinal tract (GIT), is an important target for the treatment of migraine, obesity and irritable bowel syndrome. 5-HT2BR is necessary for the myocardial cell proliferation and differentiation at the embroyonic stage for healthy development of heart. Recently, its involvement in drug induced valvulopathy and other myocardial disorders have paved a way for selective antagonist for the treatment of cardiac disorders...
July 3, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28664413/molecular-profiling-of-sarcomas-new-vistas-for-precision-medicine
#8
Tariq Al-Zaid, Wei-Lien Wang, Neeta Somaiah, Alexander J Lazar
Sarcoma is a large and heterogeneous group of malignant mesenchymal neoplasms with significant histological overlap. Accurate diagnosis can be challenging yet important for selecting the appropriate treatment approach and prognosis. The currently torrid pace of new genomic discoveries aids our classification and diagnosis of sarcomas, understanding of pathogenesis, development of new medications, and identification of alterations that predict prognosis and response to therapy. Unfortunately, demonstrating effective targets for precision oncology has been elusive in most sarcoma types...
June 29, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28662558/integrating-point-of-care-ultrasonography-into-the-osteopathic-medical-school-curriculum
#9
Brian A Russ, Danika Evans, Daniel Morrad, Codee Champney, Ashley M Woodworth, Lane Thaut, Molly Thiessen
Point-of-care ultrasonography has been shown to have pervasive clinical and educational utility in medicine. The need to provide medical students with training in point-of-care ultrasonography has been recognized by an increasing number of osteopathic and allopathic medical schools. A 4-year integrated ultrasonography curriculum was implemented at Rocky Vista University College of Osteopathic Medicine in 2015. A review of the curriculum design, content, educational methods, and student feedback are described...
July 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28659048/blocking-the-vista-pathway-enhances-disease-progression-in-nzb%C3%A2-%C3%A3-%C3%A2-nzw-f1-female-mice
#10
P A Sergent, S F Plummer, J Pettus, R Mabaera, J K DeLong, D A Pechenick, C M Burns, R J Noelle, S Ceeraz
V-domain Ig suppressor of T-cell activation (VISTA) is a critical negative checkpoint molecule involved in regulating the immune response. Targeting the pathway with an antagonist anti-VISTA antibody designated 13F3 has been shown to enhance disease severity in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. To determine if VISTA plays a role in murine lupus, New Zealand Black × New Zealand White (BWF1) mice were treated with 13F3 or control hamster Ig and disease monitored...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28658342/robotic-transversus-abdominis-release-tar-is-it-possible-to-offer-minimally-invasive-surgery-for-abdominal-wall-complex-defects
#11
Maria Vitória França DO Amaral, José Ricardo Guimarães, Paula Volpe, Flávio Malcher Martins DE Oliveira, Carlos Eduardo Domene, Sérgio Roll, Leandro Totti Cavazzola
We describe the preliminary national experience and the early results of the use of robotic surgery to perform the posterior separation of abdominal wall components by the Transversus Abdominis Release (TAR) technique for the correction of complex defects of the abdominal wall. We performed the procedures between 04/2/2015 and 06/15/2015 and the follow-up time was up to six months, with a minimum of two months. The mean surgical time was five hours and 40 minutes. Two patients required laparoscopic re-intervention, since one developed hernia by peritoneal migration of the mesh and one had mesh extrusion...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28649908/linear-perspective-and-framing-in-the-vista-paradox
#12
Marco Costa, Leonardo Bonetti
The vista paradox is the illusion in which an object seen through an aperture appears to shrink in apparent size as the observer approaches the aperture. In four studies, we tested the effect of framing and fixating on the target object. The first two studies assessed the vista paradox in a large scale naturalistic setting in which a 162.26 -m long corridor was aligned to a 97.2 -m high tower (1,407 m away). In the first study, the results showed, for each 16 m section, a mean 9.95% tower enlargement in the moving backward condition, and a mean 11...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28640813/identification-of-a-sj%C3%A3-gren-s-syndrome-susceptibility-locus-at-oas1-that-influences-isoform-switching-protein-expression-and-responsiveness-to-type-i-interferons
#13
He Li, Tove Ragna Reksten, John A Ice, Jennifer A Kelly, Indra Adrianto, Astrid Rasmussen, Shaofeng Wang, Bo He, Kiely M Grundahl, Stuart B Glenn, Corinne Miceli-Richard, Simon Bowman, Sue Lester, Per Eriksson, Maija-Leena Eloranta, Johan G Brun, Lasse G Gøransson, Erna Harboe, Joel M Guthridge, Kenneth M Kaufman, Marika Kvarnström, Deborah S Cunninghame Graham, Ketan Patel, Adam J Adler, A Darise Farris, Michael T Brennan, James Chodosh, Rajaram Gopalakrishnan, Michael H Weisman, Swamy Venuturupalli, Daniel J Wallace, Kimberly S Hefner, Glen D Houston, Andrew J W Huang, Pamela J Hughes, David M Lewis, Lida Radfar, Evan S Vista, Contessa E Edgar, Michael D Rohrer, Donald U Stone, Timothy J Vyse, John B Harley, Patrick M Gaffney, Judith A James, Sean Turner, Ilias Alevizos, Juan-Manuel Anaya, Nelson L Rhodus, Barbara M Segal, Courtney G Montgomery, R Hal Scofield, Susan Kovats, Xavier Mariette, Lars Rönnblom, Torsten Witte, Maureen Rischmueller, Marie Wahren-Herlenius, Roald Omdal, Roland Jonsson, Wan-Fai Ng, Gunnel Nordmark, Christopher J Lessard, Kathy L Sivils
Sjögren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debilitating fatigue. Dysregulation of type I interferon (IFN) pathway is a prominent feature of SS and is correlated with increased autoantibody titers and disease severity. To identify genetic determinants of IFN pathway dysregulation in SS, we performed cis-expression quantitative trait locus (eQTL) analyses focusing on differentially expressed type I IFN-inducible transcripts identified through a transcriptome profiling study...
June 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28635181/buprenorphine-requires-concomitant-activation-of-nop-and-mop-receptors-to-reduce-cocaine-consumption
#14
Marsida Kallupi, Qianwei Shen, Giordano de Guglielmo, Dennis Yasuda, V Blair Journigan, Nurulain T Zaveri, Roberto Ciccocioppo
Buprenorphine's clinical use is approved for the treatment of heroin addiction; however, evidence supporting its efficacy in cocaine abuse also exists. While for heroin it has been demonstrated that the effect of buprenorphine is mediated by its ability to activate μ-opioid peptide receptor (MOP) receptors, the mechanism through which it attenuates cocaine intake remains elusive. We explored this mechanism using operant models where rodents were trained to chronically self-administer cocaine for 2 hours daily...
June 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28633030/human-navigation-occipital-place-area-detects-potential-paths-in-a-scene
#15
E Z Patai, H J Spiers
Navigation - determining how to get from where you are to somewhere else - has obvious importance for the survival of motile animals. A new neuroimaging study has revealed that, in the human brain, the occipital place area detects the number of possible paths in a vista.
June 19, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28608363/misynpat-an-integrated-knowledge-base-linking-clinical-genetic-and-structural-data-for-disease-causing-mutations-in-human-mitochondrial-aminoacyl-trna-synthetases
#16
Luc Moulinier, Raymond Ripp, Gaston Castillo, Olivier Poch, Marie Sissler
Numerous mutations in each of the mitochondrial aminoacyl-tRNA synthetases have been implicated in human diseases. The mutations are autosomal and recessive and lead mainly to neurological disorders, although with pleiotropic effects. The processes and interactions that drive the etiology of the disorders associated with mitochondrial aminoacyl-tRNA synthetases are far from understood. The complexity of the clinical, genetic and structural data requires concerted, interdisciplinary efforts to understand the molecular biology of these disorders...
June 12, 2017: Human Mutation
https://www.readbyqxmd.com/read/28601036/light-pollution-affects-nesting-behavior-of-loggerhead-turtles-and-predation-risk-of-nests-and-hatchlings
#17
Elton Silva, Adolfo Marco, Jesemine da Graça, Héctor Pérez, Elena Abella, Juan Patino-Martinez, Samir Martins, Corrine Almeida
The introduction of artificial light into wildlife habitats is a rapidly expanding aspect of global change, which has many negative impacts on a wide range of taxa. In this experimental study, which took place on a beach located on the island of Boa Vista (Cabo Verde), three types of artificial light were tested on nesting loggerhead sea turtles as well as on ghost crabs, which intensively predate on nests and hatchlings, to determine the effects they would produce on the behavior of both species. Over the course of 36days, female loggerheads and ghost crabs were studied under yellow, orange and red lights, with observations also being made on dark nights that served as a control treatment...
June 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28585852/%C3%A2-podemos-integrar-la-atenci%C3%A3-n-nutricional-en-los-distintos-niveles-asistenciales-reflexiones-desde-la-cronicidad-y-la-complejidad-cl%C3%A3-nica
#18
Carles Blay Pueyo
En los tiempos actuales, en los que la cronicidad es el argumento casi hegemónico de los sistemas de salud, la multimorbilidad y la gestión asistencial de las necesidades complejas aparecen como retos prioritarios de las sociedades del bienestar.En un 5% de la población la dificultad de los profesionales y de los agentes para identificar y responder a lo que estos pacientes necesitan -en términos de salud- es especialmente significativa. Ello conlleva un impacto muy relevante no solo desde el punto de vista clínico, sino también en cuanto a la resiliencia de los sistemas públicos de atención a las personas...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28585851/update-en-abordaje-de-la-desnutrici%C3%A3-n-del-paciente-cr%C3%A3-nico-complejo
#19
Julia Álvarez Hernández
Este año hemos elegido como tema central del curso el "Abordaje nutricional del paciente crónico complejo", por entender que se trata de uno de los retos más importantes que tenemos los profesionales sanitarios que formamos parte de un sistema sanitario que tiene amenazada su sostenibilidad.El envejecimiento de la población es una realidad de cifras abrumadoras. Como lo es también el aumento de prevalencia de pacientes crónicos. En 2016, el 19,9% de la población española tenía 65 años o más y en 2050 se estima que un 30%-35% será mayor de 65 años y habrá algo más de 4 millones de octogenarios...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28577962/free-active-chlorine-in-sodium-hypochlorite-solutions-admixed-with-octenidine-smearoff-chlorhexidine-and-edta
#20
Unni Krishnan, Sreeja Saji, Roger Clarkson, Ratilal Lalloo, Alex J Moule
INTRODUCTION: The therapeutic effects of sodium hypochlorite (NaOCl) solutions are dependent on the levels of free available chlorine (FAC). Mixing these solutions with irrigants can result in significant reductions in FAC. Although the effect of some irrigants on FAC is known, the effect of other commonly used irrigants is not. Thus, the therapeutic ramifications of the concurrent use of these on the efficiency of NaOCl solutions is not known. METHODS: Aliquots of 5...
May 31, 2017: Journal of Endodontics
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