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JOURNAL ARTICLE
Mengzhe Lyu, Ryo Torii, Ce Liang, Thomas W Peach, Pervinder Bhogal, Levansri Makalanda, Qiaoqiao Li, Yiannis Ventikos, Duanduan Chen
Endovascular treatment has become the standard therapy for cerebral aneurysms, while the effective treatment for middle cerebral artery (MCA) bifurcation aneurysms remains a challenge. Current flow-diverting techniques with endovascular coils cover the aneurysm orifice as well as adjacent vessel branches, which may lead to branch occlusion. Novel endovascular flow disruptors, such as the Contour device (Cerus Endovascular), are of great potential to eliminate the risk of branch occlusion. However, there is a lack of valid comparison between novel flow disruptors and conventional (intraluminal) flow-diverters...
April 8, 2024: Biomechanics and Modeling in Mechanobiology
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JOURNAL ARTICLE
Yan Wu, Syed Mahfuzul Aziz, Mohammed H Haque
This article presents travel datasets of privately used vehicles for the determination of the daily charging demand of electric vehicles (EV) at a university campus and to analyse strategies to minimise the annual energy cost. The datasets have been used in the primary research article published in the Renewable Energy journal [1]. The original raw data of vehicle usage is sourced from the Victorian Integrated Survey of Travel & Activity (VISTA) [2], which is an ongoing survey led by the Department of Transport and Planning of the Victorian State Government...
June 2024: Data in Brief
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REVIEW
Shumon T Hussain, Chris Baumann
Today's biodiversity crisis fundamentally threatens the habitability of the planet, thus ranking among the primary human challenges of our time. Much emphasis is currently placed on the loss of biodiversity in the Anthropocene, yet these debates often portray biodiversity as a purely natural phenomenon without much consideration of its human dimensions and frequently lack long-term vistas. This paper offers a deep-time perspective on the key role of the evolving human niche in ecosystem functioning and biodiversity dynamics...
May 27, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
#4
JOURNAL ARTICLE
Thomas Thisted, F Donelson Smith, Arnab Mukherjee, Yuliya Kleschenko, Feng Feng, Zhi-Gang Jiang, Timothy Eitas, Kanam Malhotra, Zuzana Biesova, Adejumoke Onumajuru, Faith Finley, Anokhi Cifuentes, Guolin Zhang, Gaëlle H Martin, Yoshiko Takeuchi, Kader Thiam, Robert D Schreiber, Edward H van der Horst
VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VISTA antibodies. Here we demonstrate that SNS-101, a newly developed pH-selective VISTA antibody, addresses these challenges. Structural and biochemical analyses confirmed the pH-selectivity and unique epitope targeted by SNS-101. These properties confer favorable pharmacokinetic and safety profiles on SNS-101...
April 4, 2024: Nature Communications
#5
REVIEW
Gia Han Le, Sabrina Wong, Sebastian Badulescu, Hezekiah Au, Joshua D Di Vincenzo, Hartej Gill, Lee Phan, Taeho Greg Rhee, Roger Ho, Kayla M Teopiz, Angela T H Kwan, Joshua D Rosenblat, Rodrigo B Mansur, Roger S McIntyre
BACKGROUND: Electrophysiologic measures provide an opportunity to inform mechanistic models and possibly biomarker prediction of response. Serotonergic psychedelics (SPs) (i.e., psilocybin, lysergic acid diethylamide (LSD)) and ketamine represent new investigational and established treatments in mood disorders respectively. There is a need to better characterize the mechanism of action of these agents. METHODS: We conducted a systematic review investigating the spectral signatures of psilocybin, LSD, and ketamine in persons with major depressive disorder (MDD), treatment-resistant depression (TRD), and healthy controls...
April 1, 2024: Journal of Affective Disorders
#6
JOURNAL ARTICLE
Bahar Naseri, Amirhossein Mardi, Arezou Khosrojerdi, Elham Baghbani, Leili Aghebati-Maleki, Amirhossein Hatami-Sadr, Javad Ahmadian Heris, Shabnam Eskandarzadeh, Mahshid Kafshdouz, Nazila Alizadeh, Behzad Baradaran
BACKGROUND: Antigen-specific T-cell immunity is provided by dendritic cells (DCs), which are specialized antigen-presenting cells. Furthermore, they establish a link between innate and adaptive immune responses. Currently, DC modification is a new approach for the therapy of several disorders. During solid organ transplantation, Everolimus, which is a mammalian target of rapamycin (mTOR) inhibitor, was initially utilized to suppress the immune system's functionality. Due to the intervention of Everolimus in various signaling pathways in cells and its modulatory properties on the immune system, this study aims to investigate the effect of treatment with Everolimus on the maturation and expression of immune checkpoint genes in monocyte-derived DCs...
April 1, 2024: Human Immunology
#7
JOURNAL ARTICLE
Valerio Da Ros, Federico Sabuzi, Francesco D'Argento, Alessandro Pedicelli, Vladimir Gavrilovic, Massimo Sponza, Francesca Di Giuliano, Francesco Biraschi, Marta Iacobucci, Giovanni Grillea, Andrea Bartolo, Mirko Patassini, Paolo Remida, Luca Quilici, Giuseppe Faragò, Marco Varrassi, Nicola Cavasin, Roberto Arpesani, Aldo Victor Giordano, Giuseppe Umana, Francesco Garaci, Roberto Floris
PURPOSE: The aim of this registry was to assess technical success, procedural safety and mid- to long-term follow-up results of the Silk Vista "Mama" (SVM) flow diverter (BALT, Montmorency, France) for the treatment of proximal intracranial aneurysms. METHODS: Between August 2020 and March 2022, data from nine Italian neurovascular centres were collected. Data included patients' clinical presentation, aneurysms' size, location and status, technical details, overall complications and mid- to long-term angiographic follow-up...
April 2, 2024: Neuroradiology
#8
REVIEW
Prachi Mhettar, Niraj Kale, Jidnyasa Pantwalawalkar, Sopan Nangare, Namdeo Jadhav
BACKGROUND AND PURPOSE: Metal-organic frameworks (MOFs) have gained incredible consideration in the biomedical field due to their flexible structural configuration, tunable pore size and tailorable surface modification. These inherent characteristics of MOFs portray numerous merits as potential drug carriers, depicting improved drug loading, site-specific drug delivery, biocompatibility, biodegradability, etc. REVIEW APPROACH: The current review article sheds light on the synthesis and use of MOFs in drug delivery applications...
2024: ADMET & DMPK
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JOURNAL ARTICLE
Yusheng Lin, Ghizlane Choukrani, Lena Dubbel, Lena Rockstein, Jimena Alvarez Freile, Yuzhu Qi, Valerie Wiersma, Hao Zhang, Karl-Wilhelm Koch, Emanuele Ammatuna, Jan Jacob Schuringa, Tom van Meerten, Gerwin Huls, Edwin Bremer
BACKGROUND: VISTA is a well-known immune checkpoint in T cell biology, but its role in innate immunity is less established. Here, we investigated the role of VISTA on anticancer macrophage immunity, with a focus on phagocytosis, macrophage polarization and concomitant T cell activation. METHODS: Macrophages, differentiated from VISTA overexpressed THP-1 cells and cord blood CD34+ cell-derived monocytes, were used in phagocytosis assay using B lymphoma target cells opsonized with Rituximab...
March 29, 2024: Experimental Hematology & Oncology
#10
JOURNAL ARTICLE
Norikazu Koori, Hiroki Kamekawa, Takehiro Naito, Yasuo Takatsu, Hiraku Fuse, Shin Miyakawa, Kenji Yasue, Masato Takahashi, Kazuma Kurata
BACKGROUND: We devised a method that combines the 3D-Dixon-gradientecho (GRE) method with an improved motion-sensitized driven-equilibrium (iMSDE) to suppress blood flow signals. PURPOSE: The purpose of this study was to evaluate the effectiveness of the new method we developed plaque imaging method (3D-Dixon-GRE with the iMSDE method). STUDY TYPE: Retrospective cohort. POPULATION: Thirty-nine patients who underwent cervical plaque imaging...
March 26, 2024: Magnetic Resonance Imaging
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JOURNAL ARTICLE
Jun Ho Hwang, Chang Kyu Park, Seok Bin Kang, Man Kyu Choi, Won Hee Lee
This study aimed to implement a deep learning-based super-resolution (SR) technique that can assist in the diagnosis and surgery of trigeminal neuralgia (TN) using magnetic resonance imaging (MRI). Experimental methods applied SR to MRI data examined using five techniques, including T2-weighted imaging (T2WI), T1-weighted imaging (T1WI), contrast-enhancement T1WI (CE-T1WI), T2WI turbo spin-echo series volume isotropic turbo spin-echo acquisition (VISTA), and proton density (PD), in patients diagnosed with TN...
March 7, 2024: Life
#12
JOURNAL ARTICLE
Hamed Ekhtiari, Arash Khojasteh Zonoozi, Parnian Rafei, Fateme Sadat Abolghasemi, Dan Pemstein, Tarek Abdelgawad, Sophia Achab, Hamad Al Ghafri, Mustafa Al'Absi, Michaël Bisch, Aldo Alberto Conti, Atul Ambekar, Shalini Arunogiri, Roshan Bhad, Rabia Bilici, Kathleen Brady, Gregory Bunt, Anja Busse, Jenna L Butner, Ahmad Danesh, Joseph El-Khoury, Fatima El Omari, Darius Jokūbonis, Cor de Jong, Geert Dom, Mohsen Ebrahimi, Ali Fathi Jouzdani, Marica Ferri, Susanna Galea-Singer, Dario Gigena Parker, Susumu Higuchi, Preethy Kathiresan, Emira Khelifa, Christos Kouimtsidis, Evgeny M Krupitsky, Jiang Long, Icro Maremmani, Garrett McGovern, Hossein Mohaddes Ardabili, Afarin Rahimi-Movaghar, Solomon Tshimong Rataemane, Arshiya Sangchooli, Goodman Sibeko, Anna Maria Vella, Salvador Benjamin D Vista, Mehran Zare-Bidoky, Min Zhao, Afzal Javed, Marc N Potenza, Alexander Mario Baldacchino
Addiction medicine is a dynamic field that encompasses clinical practice and research in the context of societal, economic, and cultural factors at the local, national, regional, and global levels. This field has evolved profoundly during the past decades in terms of scopes and activities with the contribution of addiction medicine scientists and professionals globally. The dynamic nature of drug addiction at the global level has resulted in a crucial need for developing an international collaborative network of addiction societies, treatment programs and experts to monitor emerging national, regional, and global concerns...
2024: Frontiers in Psychiatry
#13
JOURNAL ARTICLE
Madeline D Mott, Briana Trusiano, Irving Coy Allen
No abstract text is available yet for this article.
March 25, 2024: Journal of Leukocyte Biology
#14
EDITORIAL
Roger S McIntyre
No abstract text is available yet for this article.
March 23, 2024: Expert Opinion on Drug Safety
#15
JOURNAL ARTICLE
Suguru Saito, Najmeh Bozorgmehr, Wendy Sligl, Mohammed Osman, Shokrollah Elahi
Severe SARS-CoV-2 infection is associated with significant immune dysregulation involving different immune cell subsets. In this study, when analyzing critically ill COVID-19 patients versus those with mild disease, we observed a significant reduction in total and memory B cell subsets but an increase in naive B cells. Moreover, B cells from COVID-19 patients displayed impaired effector functions, evidenced by diminished proliferative capacity, reduced cytokine, and Ab production. This functional impairment was accompanied by an increased apoptotic potential upon stimulation in B cells from severely ill COVID-19 patients...
March 22, 2024: Journal of Immunology
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JOURNAL ARTICLE
Patrick S Forsythe, Justice A Saxby, Haillee R Fritsch, Noah P Hoffmann, Teona T Ditzman, Deakyn J Suess, Kelsey A Radobicky, Bennett A Schmitz, Samantha D Amasone, Charles K Buchmann, Laken T Schultz, Addison L Clauer, Allison S Vista, April M Kienbaum, Megan R Ryan-Rabe, Brooklyn A M Monfils, Bryan A Lara, Michael L Draney
It is important to have reliable information on the presence/absence, population structure, and density of animals across their natural range. Detecting small organisms, however, such as the Nearctic tree trunk sheetweaver spider Drapetisca alteranda Chamberlin 1909 (Araneae: Linyphiidae), presents challenges due to its diminutive size and cryptic nature. We used a capture/recapture study to determine the detection and recapture probabilities of this spider using a standard beat sheet technique adopted for surveying tree trunks...
March 21, 2024: Environmental Entomology
#17
JOURNAL ARTICLE
Stan Floresco, Angela Roberts, Emma Robinson, Diego A Pizzagalli
Preclinical research is an essential aspect of biomedical science that aids in clarifying the pathophysiology of underlying illness and devising new treatments. This special issues brings together original research and review papers that pertain to the development of novel models and behavioral assays of symptoms of neuropsychiatric disorders, which may help to refine preclinical studies and to improve their translatability to the human condition.
March 19, 2024: Cognitive, Affective & Behavioral Neuroscience
#18
JOURNAL ARTICLE
D Nishizaki, R Kurzrock, H Miyashita, J J Adashek, S Lee, M Nikanjam, R N Eskander, H Patel, G P Botta, M K Nesline, S Pabla, J M Conroy, P DePietro, J K Sicklick, S Kato
BACKGROUND: Optimizing immune checkpoint inhibitor (ICI) therapy may require identification of co-targetable checkpoint pathways via immune profiling. Herein, we analyzed the transcriptomic expression and clinical correlates of V-domain immunoglobulin suppressor of T-cell activation (VISTA), a promising targetable checkpoint. PATIENTS AND METHODS: RNA sequencing was carried out on 514 tissues reflecting diverse advanced/metastatic cancers. Expression of eight immune checkpoint markers [lymphocyte-activation gene 3 (LAG-3), tumor necrosis factor receptor superfamily 14 (TNFRSF14), programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), programmed death-ligand 2 (PD-L2), B- and T-lymphocyte attenuator (BTLA), T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), cytotoxic T-lymphocyte antigen 4 (CTLA-4)], in addition to VISTA, was analyzed, along with clinical outcomes...
March 18, 2024: ESMO Open
#19
JOURNAL ARTICLE
Florian Schuster, Benedikt W Grau, Hong-Gui Xu, Andriy Mokhir, Svetlana B Tsogoeva
Reactions for drug synthesis under cell-like conditions or even inside living cells can potentially be used e.g., to minimize toxic side effects, to maximize bioactive compound efficacy and/or to address drug delivery problems. Those reactions should be bioorthogonal to enable the generation of drug-like compounds with sufficiently good yields. In the known bioorthogonal Michael reactions, using thiols and phosphines as nucleophiles (e.g., in CS and CP bond formation reactions) is very common. No bioorthogonal Michael addition with a carbon nucleophile is known yet...
February 22, 2024: Bioorganic & Medicinal Chemistry
#20
JOURNAL ARTICLE
Nicolas Skalicky, Katja Hatz-Wurziger
BACKGROUND: The goals of this study are to evaluate potential long-term visual deterioration associated with retinal pigment epithelial (RPE) tears in patients with neovascular age-related macular degeneration (nAMD) and to find treatment-related and morphological factors that might influence the outcomes. PATIENTS AND METHODS: This retrospective study enrolled 21 eyes of 21 patients from the database of Vista Eye Clinic Binningen, Switzerland, diagnosed with RPE tears, as confirmed by spectral domain optical coherence tomography (SD-OCT), with a minimum follow-up period of 12 months...
March 14, 2024: Klinische Monatsblätter Für Augenheilkunde
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