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Hirofumi Shimada, Toshiyasu Ogata, Koichi Takano, Hiroshi Abe, Toshio Higashi, Takaaki Yamashita, Akira Matsunaga, Tooru Inoue
BACKGROUND: The association of carotid plaque enhancement on contrast-enhanced carotid ultrasound (CEUS) and plaque vulnerability evaluated by magnetic resonance imaging (MRI) was to be determined. MATERIALS AND METHODS: The 103 patients underwent CEUS from May 2013 until June 2016. CEUS images of the carotid plaque were obtained offline. Plaque images obtained at 1, 3, 5, and 10 minutes were compared with the reference image, defined as the image obtained at 0 minute...
October 10, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
A T Djami-Tchatchou, K Ntushelo
BACKGROUND: Pectobacterium carotovorum subsp. carotovorum (Pcc) is a soft rot bacterium which upon entry into the plant macerates plant tissues by producing plant cell wall degrading enzymes. It has a wide host range which includes carrot, potato, tomato, leafy greens, squash and other cucurbits, onion, green peppers and cassava. During plant-microbe interactions, one of the ways of plant response to pathogen infection is through the small RNA silencing mechanism. Under pathogen attack the plant utilizes microRNAs to regulate gene expression by means of mediating gene silencing at transcriptional and post-transcriptional level...
2017: Pakistan Journal of Biological Sciences: PJBS
Christopher R McCudden, John Brooks, Priya Figurado, Pierre R Bourque
BACKGROUND: Reference intervals are vital for interpretation of laboratory results. Many existing reference intervals for cerebrospinal fluid total protein (CSF-TP) are derived from old literature because of the invasive nature of sampling. The objective of this study was to determine reference intervals for CSF-TP using available patient data. METHODS: Twenty years of hospital database information was mined for previously reported CSF-TP results. Associated demographic, laboratory, and clinical diagnosis (International Classification of Diseases 9/10 codes) details were extracted...
October 11, 2017: Clinical Chemistry
Arshad H Rahmani, Mohammed A Alsahli, Saleh A Almatroodi
The treatment based on plant or plant derivatives is a promising strategy in the killing of cancers cells. Moreover, wide-ranging finding has established that medicinal plant and its ingredient modulate several cells signaling pathways or inhibiting the carcinogenesis process. In this vista, pomegranates fruits, seeds and peels illustrate cancer preventive role seems to be due to rich source of antioxidant and other valuable ingredients. Furthermore, anti-tumour activities of pomegranates have been evidences through the modulation of cell signaling pathways including transcription factor, apoptosis and angiogenesis...
July 2017: Pharmacognosy Reviews
Samantha Burugu, Amanda R Dancsok, Torsten O Nielsen
The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1) targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor immune responses. These agents led to unprecedented results in patients with previously incurable metastatic disease and may become first-line therapies for some advanced cancers. However, these agents are efficacious in only a minority of patients. Newer strategies are becoming available that target additional immunomodulatory mechanisms to activate patients' own anti-tumor immune responses...
October 5, 2017: Seminars in Cancer Biology
Utaru Tanaka, Yoshiko Ueno, Yukiko Morinaga, Hideaki Miyake, Katsusuke Kyotani, Yu Ueda, Kazuhiro Kitajima, Keitaro Sofue, Yuko Suenaga, Kazuro Sugimura, Satoru Takahashi
PURPOSE: To investigate the impact of three-dimensional (3D) T2-weighted turbo spin-echo imaging (TSE-T2WI) with tissue-specific variable refocusing flip angle (TS-VRFA) on image quality and prostate cancer (PCa) detection and extraprostatic extension (EPE) evaluation compared to 2D TSE-T2WI and conventional 3D TSE-T2WI with volume isotropic TSE acquisition (VISTA). MATERIALS AND METHODS: Image data sets of 40 patients who underwent 3-T MRI before prostatectomy, including multiplane 2D T2WI, 3D T2WI with TS-VRFA and VISTA, and diffusion-weighted images were independently evaluated by two radiologists...
October 5, 2017: Japanese Journal of Radiology
Bony De Kumar, Hugo J Parker, Ariel Paulson, Mark E Parrish, Julia Zeitlinger, Robb Krumlauf
Hoxa1 has important functional roles in neural crest specification, hindbrain patterning and heart and ear development, yet the enhancers and genes that are targeted by Hoxa1 are largely unknown. In this study, we performed a comprehensive analysis of Hoxa1 target genes using genome-wide Hoxa1 binding data in mouse ES cells differentiated with retinoic acid (RA) into neural fates in combination with differential gene expression analysis in Hoxa1 gain- and loss-of-function mouse and zebrafish embryos. Our analyses reveal that Hoxa1-bound regions show epigenetic marks of enhancers, occupancy of Hox cofactors and differential expression of nearby genes, suggesting that these regions are enriched for enhancers...
October 2, 2017: Developmental Biology
Aswathy Kaimal, Poojya Ramdev, C S Shruthi
INTRODUCTION: Yttria stabilised tetragonal zirconia opens new vistas for all ceramic restoration by the mechanism of transformation toughening, making it much stronger compared to all other ceramic materials. Currently, it is the most recent core material for all ceramic fixed partial dentures due to its ability to withstand high simulated masticatory loads. Problems which have been reported with zirconia restorations involve the core cement interface leading to loss of retention of the prosthesis...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
F Silva Pinto, R Cunha Marques
Water utilities face different challenges that may force them to seek prioritized objectives. When doing so, particular projects may have to be developed, being important to understand their impact on water tariffs, and thus, on customers. Such consequences may bear an increased relevance in cases stressed with, e.g., resource scarcity, poverty, and the need for infrastructure investments. The resulting cost and revenue variability demand a comprehensive study. If the first may require a stochastic modeling (in major cost components) in order to consider its inherent uncertainty, the second needs to be modeled following context-specific objectives set by the relevant stakeholders...
September 13, 2017: Water Research
E Ann Yeh, Jay Greenberg, Oussama Abla, Giulia Longoni, Eli Diamond, Michelle Hermiston, Brandon Tran, Carlos Rodriguez-Galindo, Carl E Allen, Kenneth L McClain
Central nervous system (CNS) involvement in Langerhans cell histiocytosis (LCH) can include mass lesions of the hypothalamic pituitary axis, choroid plexus, cerebrum, and cerebellum or magnetic resonance imaging (MRI) signal abnormalities of the cerebellum, pons, and basal ganglia. The term neurodegenerative (ND) CNS-LCH has been given to the MRI signal abnormalities and neurologic dysfunction, although initially patients may have no clinical symptoms. Standardized evaluations to better understand the natural history and response to therapy are needed...
September 25, 2017: Pediatric Blood & Cancer
Aaron Prodeus, Aws Abdul-Wahid, Amanda Sparkes, Nicholas W Fischer, Marzena Cydzik, Nicholas Chiang, Mays Alwash, Alessandra Ferzoco, Nathalie Vacaresse, Michael Julius, Reginald M Gorczysnki, Jean Gariépy
V-domain immunoglobulin suppressor of T cell activation (VISTA) is a recently discovered immune checkpoint ligand that functions to suppress T cell activity. The therapeutic potential of activating this immune checkpoint pathway to reduce inflammatory responses remains untapped, largely due to the inability to derive agonists targeting its unknown receptor. A dimeric construct of the IgV domain of VISTA (VISTA-Fc) was shown to suppress the activation of T cells in vitro. However, this effect required its immobilization on a solid surface, suggesting that VISTA-Fc may display limited efficacy as a VISTA-receptor agonist in vivo...
September 21, 2017: JCI Insight
Cristine A Roberts, Jennifer Hunter, An-Lin Cheng
PURPOSE: About 80% of children with autism spectrum disorder (ASD) have sleep problems that may disrupt optimal family functioning. We explored the impact of sleep problems on families' resilience. DESIGN AND METHODS: An explanatory sequential mixed methods design was used to discern whether resilience differed between families whose children with ASD have or do not have sleep problems, to seek predictors for family hardiness/resilience, and to determine whether narrative findings support, expand, or conflict quantitative findings...
September 12, 2017: Journal of Pediatric Nursing
G Shwetha, Prakash Chandra, Latha Anandakrishna, G Dhananjaya, Ashmitha K Shetty, Punitha S Kamath
AIM AND OBJECTIVE: To estimate the accuracy and assess the sensitivity and specificity of direct visual examination (DVE), computerized radiograph (VISTA SCAN mini), and DIAGNOdent (DD) for caries diagnosis in primary molars as compared to histological examination of the teeth. MATERIALS AND METHODS: An in vitro comparative study was carried out on 40 freshly extracted primary molars with questionable pit and fissures that yielded 89 examination sites. These samples were mounted on plaster and were subjected to examination methods for caries detection on the occlusal surface by two trained and calibrated examiners...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
Alessandro De Stefano, Liliana Mannucci, Renato Massoud, Sergio Bernardini, Claudio Cortese
INTRODUCTION: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a marker of vascular inflammation associated with coronary heart disease and stroke. We evaluated analytical performance of the PLAC® Activity Test on Siemens Dimension Vista® 1500 analyzer and measured Lp-PLA2 activity in Italian adults to establish reference intervals (RIs) and evaluate correlation with circulating lipids and age. MATERIALS AND METHODS: The evaluation protocol consisted of precision, linearity, sensitivity, method comparison, substrate depletion ("hook") effect and interference assessment...
October 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Urmila U Tambewagh, Amit D Kandhare, Varsha S Honmore, Parag P Kadam, Vijay M Khedkar, Subhash L Bodhankar, Supada R Rojatkar
BACKGROUND: Inflammation activated by oxidative stress can cause various diseases, such as asthma, rheumatoid arthritis, cancer, diabetes, etc. Plant constituents with sesquiterpene lactones possess antioxidant and anti-inflammatory properties. AIM: To determine the antioxidant and anti-inflammatory potential of isolated phytoconstituent from Cyathocline purpurea Buch-Ham ex D (CP). Don in laboratory animals. Furthermore, to understand the interactions involved in the binding of this compound to cyclooxygenase-2 (COX-2) via computational docking...
November 2017: International Immunopharmacology
Reza M Moghadam, Zhiyong Xiao, Kamyar Ahmadi-Majlan, Everett D Grimley, Mark Bowden, Phuong-Vu Ong, Scott A Chambers, James M Lebeau, Xia Hong, Peter V Sushko, Joseph H Ngai
The epitaxial growth of multifunctional oxides on semiconductors has opened a pathway to introduce new functionalities to semiconductor device technologies. In particular, the integration of gate materials that enable nonvolatile or hysteretic functionality in field-effect transistors could lead to device technologies that consume less power or allow for novel modalities in computing. Here we present electrical characterization of ultrathin single crystalline SrZrxTi1-xO3 (x = 0.7) films epitaxially grown on a high mobility semiconductor, Ge...
October 11, 2017: Nano Letters
Wei Yang, Søren Berg Padkjær, Jishu Wang, Zhe Sun, Bing Shan, Li Yang, Haibin Chen, Lishan Kang, Dennis Madsen, Xun Li, Chenxi Shen, Bingke Yu, Haisun Zhu, Tzu-Yuan Chao, Zhuoxiao Cao, Dapeng Li, Wei Liu, Yanping Du, Jinjing Xu, Dongxia Hao, Fengting Xu, Lujia Peng, Tengkun Li, Lin Wang, Lin Li, Haimei Xing, Di Liu, Zibing Liu, Zhishuang Guan, Wan Wang, Hong Cheng, Henrik Østergaard, Chihchuan Chang, Zhiru Yang, Esper Boel, Jing Su
Interactions between protein ligands and receptors play crucial roles in cell-cell signalling. Most of the human cell surface receptors have been identified in the post-Human Genome Project era but many of their corresponding ligands remain unknown. To facilitate the pairing of orphan receptors, 2762 sequences encoding all human single-pass transmembrane proteins were selected for inclusion into a mammalian-cell expression library. This expression library, consisting of all the individual extracellular domains (ECDs), was constructed as a Fab fusion for each protein...
September 1, 2017: Journal of Biotechnology
Jung Eun Lee, Hee Jin Park, So Yeon Lee, Jin Hwan Ahn, Jai Hyung Park, Ji Yeon Park
OBJECTIVE: The purpose of this study was to compare the diagnostic utility of oblique sagittal and oblique coronal 3D volume isotropic turbo spin-echo acquisition (VISTA) images with that of 2D fast spin-echo (FSE) T2-weighted images in the diagnosis of selective bundle tears of the anterior cruciate ligament (ACL). MATERIALS AND METHODS: This retrospective study included 56 patients who underwent 2D FSE and 3D VISTA 3-T MRI of the knee before arthroscopic procedures...
August 31, 2017: AJR. American Journal of Roentgenology
Pierfrancesco Maria Balducci, Chiara Gobbicchi, Patrizia Moretti, Alfonso Tortorella
RIASSUNTO. La folie à deux (FAD) è una condizione clinica osservata per la prima volta nella storia da Lasègue e Falret nel XIX secolo. Descrissero una rara circostanza nella quale due o più persone si ritrovarono a condividere idee deliranti gli uni dagli altri. Oggigiorno tracce di questa diagnosi del passato e del suo substrato psicopatologico si ritrovano nell'ICD-10, in cui la FAD viene codificata come "Disturbo Psicotico Condiviso". Considerando la scarsa letteratura in merito e la mancanza di una ben precisa definizione sintomatologica, risulta difficile circoscrivere i confini clinici della FAD...
July 2017: Rivista di Psichiatria
Elwira Bisz, Michal Szostak
Oxygen-based electrophiles have emerged as some of the most valuable cross-coupling partners in organic synthesis due to several major strategic and environmental benefits such as abundance and potential to avoid toxic halide waste. In this context, iron-catalyzed C-O activation/cross-coupling holds particular promise to achieve sustainable catalytic protocols due to its natural abundance, inherent low toxicity, an excellent economic and ecological profile. Recently, tremendous progress has been achieved in the development of new methods for functional group tolerant iron-catalyzed cross-coupling reactions by selective C-O cleavage...
August 24, 2017: ChemSusChem
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