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https://www.readbyqxmd.com/read/29045900/molecular-and-functional-characterization-of-lymphoid-progenitor-subsets-reveals-a-bipartite-architecture-of-human-lymphopoiesis
#1
Kutaiba Alhaj Hussen, Thien-Phong Vu Manh, Fabien Guimiot, Elisabeth Nelson, Emna Chabaane, Marc Delord, Maxime Barbier, Claire Berthault, Nicolas Dulphy, Antonio José Alberdi, Odile Burlen-Defranoux, Gerard Socié, Jean Christophe Bories, Jerôme Larghero, Valérie Vanneaux, Els Verhoeyen, Thierry Wirth, Marc Dalod, Jean Claude Gluckman, Ana Cumano, Bruno Canque
The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127(-) and CD127(+) early lymphoid progenitors (ELPs). Combining molecular analyses with in vitro and in vivo functional assays, we demonstrated that CD127(-) and CD127(+) ELPs emerged independently from lympho-mono-dendritic progenitors, responded differently to Notch1 signals, underwent divergent modes of lineage restriction, and displayed both common and specific differentiation potentials...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045670/impact-of-age-related-mitochondrial-dysfunction-and-exercise-on-intestinal-microbiota-composition
#2
David Houghton, Christopher J Stewart, Craig Stamp, Andrew Nelson, Nadim J Ajami, Joseph F Petrosino, Anil Wipat, Michael I Trenell, Douglass M Turnbull, Laura C Greaves
Mitochondrial dysfunction is prevalent in the ageing gastrointestinal tract. We investigated whether mitochondrial function in ageing colonic crypts and exercise influence microbial gut communities in mice. Twelve PolgAmut/mut mice were randomly divided into a sedentary and exercise group at 4 months. Seven aged matched PolgA+/+ mice remained sedentary throughout. Stool samples were collected at 4, 7 and 11 months, and bacterial profiling was achieved through 16S rDNA sequencing profiling. Mitochondrial enzyme activity was assessed in colonic epithelial crypts at 11 months for PolgAmut/mut and PolgA+/+ mice...
October 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29045548/bold-activity-during-correct-answer-feedback-in-cued-recall-predicts-subsequent-retrieval-performance-an-fmri-investigation-using-a-partial-trial-design
#3
Adrian W Gilmore, Steven M Nelson, Farah Naaz, Ruth A Shaffer, Kathleen B McDermott
Receiving correct answer feedback following a retrieval attempt has proven to be a highly effective means of learning new information, yet the mechanisms behind its efficacy remain poorly understood. Here, fMRI was used to examine how BOLD activity measured during a period of feedback could predict subsequent memory (SM) performance on a final test. Twenty-five human subjects studied pairs of associated words, and were then asked to covertly recall target words in response to provided cues. Correct answer feedback was provided immediately after covert retrieval attempts...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29045273/oneflorida-clinical-research-consortium-linking-a-clinical-and-translational-science-institute-with-a-community-based-distributive-medical-education-model
#4
Elizabeth Shenkman, Myra Hurt, William Hogan, Olveen Carrasquillo, Steven Smith, Andrew Brickman, David Nelson
PROBLEM: Developing a national pragmatic clinical trial infrastructure is central to understanding the effectiveness of interventions applied under usual conditions and where people receive health care. To address this challenge, three Florida universities- the University of Florida Clinical and Translational Science Institute, Florida State University (with its community-based distributive medical education model), and the University of Miami-created (2010-2013) a statewide consortium, the OneFlorida Clinical Research Consortium, to support the conduct of pragmatic clinical trials and provide mentored research experiences for medical and graduate students in real-world practice settings...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29045081/chasing-bubbles-for-cancer-diagnostics-cancer-researchers-are-pursuing-membrane-bound-microbubbles-and-exosomes-as-new-diagnostic-tools
#5
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#6
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29044894/immediate-implant-placement-and-provisionalization-following-tumor-resective-surgery-in-the-midfacial-region-a-case-series
#7
Nelson Fernandes, Jacobus van den Heever, Leanne Sykes
Surgical and prosthodontic restoration of the midfacial region following tumor resection has always posed a considerable challenge, as this area serves crucial functional and esthetic roles. Being diagnosed and subsequently treated for facial tumors can have an immense psychosocial impact on a patient, as the resulting defects are often disfiguring, and lead to an inability to masticate, swallow, and speak clearly. Provision of an immediate facial and dental prosthesis at the time of surgery can limit these side effects and help reduce mental duress on these patients and their families, as well as aid in the process of rehabilitation...
October 18, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29044736/multiscale-humidity-visualization-by-environmentally-sensitive-fluorescent-molecular-rotors
#8
Yanhua Cheng, Jianguo Wang, Zijie Qiu, Xiaoyan Zheng, Nelson L C Leung, Jacky W Y Lam, Ben Zhong Tang
Building humidity sensors possessing the features of diverse-configuration compatibility, and capability of measurement of spatial and temporal humidity gradients is of great interest for highly integrated electronics and wearable monitoring systems. Herein, a visual sensing approach based on fluorescent imaging is presented, by assembling aggregation-induced-emission (AIE)-active molecular rotors into a moisture-captured network; the resulting AIE humidity sensors are compatible with diverse applications, having tunable geometries and desirable architectures...
October 16, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29044627/managing-making-sense-of-and-finding-meaning-in-advanced-illness-a-qualitative-exploration-of-the-coping-and-wellbeing-experiences-of-patients-with-lung-cancer
#9
Emily Harrop, Simon Noble, Michelle Edwards, Stephanie Sivell, Barbara Moore, Annmarie Nelson
Coping plays an essential role in maintaining the wellbeing of patients with cancer. A number of different coping responses and strategies have been identified in the literature. The value and relevance of meaning based coping theory has also been emphasised, including Antonovosky's Sense of Coherence (SoC) theory. Ten patients with advanced lung cancer were interviewed up to three times. A total of twenty in depth interviews were carried out, fully transcribed and data were analysed following a methodology of Interpretative Phenomenological Analysis...
October 16, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29043885/first-report-of-hb-kent-%C3%AE-37-c3-trp%C3%A2-cys-tgg-tgc-hbb-c-114g-c-in-a-chinese-family
#10
Nelson C N Chan, King-Ho Chow, Rico F Y Leung, Sequence S H Tang, Michelle F W Chiu, Rosalind Lie, Kelvin C K Cheng, Kin-Mang Lau, Natalie P H Chan, Margaret H L Ng
We report a novel HBB: c.114G>C mutation in a Chinese family. This mutation resulted in a β37(C3)Trp→Cys amino acid substitution and was synonymous with Hb Kent, a hemoglobin (Hb) variant that was reported exclusively in patients of European descent. Though Hb Kent has a normal oxygen affinity and molecular stability, it has a characteristic dual variant appearance on cellulose acetate electrophoresis (CAE) and high performance liquid chromatography (HPLC) caused by the posttranslational modification of cysteine...
October 18, 2017: Hemoglobin
https://www.readbyqxmd.com/read/29043096/sex-determination-using-humeral-dimensions-in-a-sample-from-kwazulu-natal-an-osteometric-study
#11
Oluwatosin Olalekan Ogedengbe, Sunday Adelaja Ajayi, Omobola Aderibigbe Komolafe, Aung Khaing Zaw, Edwin Coleridge Stephen Naidu, Onyemaechi Okpara Azu
The morphological characteristics of the humeral bone has been investigated in recent times with studies showing varying degrees of sexual dimorphism. Osteologists and forensic scientists have shown that sex determination methods based on skeletal measurements are population specific, and these population-specific variations are present in many body dimensions. The present study aims to establish sex identification using osteometric standards for the humerus in a contemporary KwaZulu-Natal population. A total of 11 parameters were measured in a sample of n=211 humeri (males, 113; females, 98) from the osteological collection in the Discipline of Clinical Anatomy, Nelson R...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042406/what-data-sources-do-ophthalmologists-trust
#12
William C Stewart, Jeanette A Stewart, Lindsay A Nelson
To survey ophthalmologists regarding sources they trust when incorporating new medical knowledge into their practice. The survey was distributed primarily to US-based ophthalmologists. Questions were derived based on the lead author's research experience from congresses and discussions and from mentions in the medical literature. In total, 77 physicians completed the survey of 1886 sent (4% response rate). Regarding study design, physicians preferred a well-controlled, randomised, double-masked trial (99%) with multicentred investigational site across a wide geographical area (80%)...
October 17, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/29042008/risky-business-investigating-outcomes-of-patients-undergoing-urgent-laparoscopic-appendectomy-on-antithrombotic-therapy
#13
Christopher Pearcy, Khalid Almahmoud, Theresa Jackson, Cassie Hartline, Anthony Cahill, Lara Spence, Dennis Kim, Oluwabukola Olatubosun, S Rob Todd, Eric M Campion, Clay Cothren Burlew, Justin Regner, Richard Frazee, David Michaels, Sharmila Dissanaike, Collin Stewart, Neal Foley, Paul Nelson, Vaidehi Agrawal, Michael S Truitt
No abstract text is available yet for this article.
October 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29041977/perceptions-of-and-barriers-to-family-planning-services-in-the-poorest-regions-of-chiapas-mexico-a-qualitative-study-of-men-women-and-adolescents
#14
Emily Dansereau, Alexandra Schaefer, Bernardo Hernández, Jennifer Nelson, Erin Palmisano, Diego Ríos-Zertuche, Alex Woldeab, Maria Paola Zúñiga, Emma Margarita Iriarte, Ali H Mokdad, Charbel El Bcheraoui
BACKGROUND: In the poorest regions of Chiapas, Mexico, 50.2% of women in need of contraceptives do not use any modern method. A qualitative study was needed to design effective and culturally appropriate interventions. METHODS: We used purposive maximum-variation sampling to select eight municipalities with a high proportion of residents in the poorest wealth quintile, including urban, rural, indigenous, and non-indigenous communities. We conducted 44 focus group discussions with 292 women, adolescent women, and men using semi-structured topic guides...
October 17, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29039892/step-by-step-male-to-female-transsexual-surgery
#15
Rodrigo Uliano Moser da Silva, Fernando Jahn da Silva Abreu, Gabriel M V da Silva, João Vitor Quadra Vieira Dos Santos, Nelson Sivonei da Silva Batezini, Brasil Silva, Tiago Elias Rosito
INTRODUCTION: After the diagnosis of transsexualism is confirmed therapy commences with psychotherapeutic preparation for the conversion, and after conversion, long-term patient rehabilitation is maintained for at least two years. The indication for surgery is chronic discomfort caused by discord with the patient's natural gender, intense dislike of developing secondary sex characteristics and the onset of puberty. The surgical conversion of transsexuals is the main step in the complex care of these problematic patients (1)...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29039747/development-of-useful-biomaterial-for-bone-tissue-engineering-by-incorporating-nano-copper-zinc-alloy-ncuzn-in-chitosan-gelatin-nano-hydroxyapatite-ch-g-nhap-scaffold
#16
Juan Carlos Forero, Eduardo Roa, Juan G Reyes, Cristian Acevedo, Nelson Osses
Ceramic and metallic nanoparticles can improve the mechanical and biological properties of polymeric scaffolds for bone tissue engineering (BTE). In this work, nanohydroxyapatite (nHAp) and nano-copper-zinc alloy (nCuZn) were added to a chitosan/gelatin (Ch/G) scaffold in order to investigate the effects on morphological, physical, and biocompatibility properties. Scaffolds were fabricated by a freeze-drying technique using different pre-freezing temperatures. Microstructure and morphology were studied by scanning electron microscopy (SEM), glass transition (Tg) was studied using differential scanning calorimetry (DSC), cell growth was estimated by MTT assay, and biocompatibility was examined in vitro and in vivo by histochemistry analyses...
October 17, 2017: Materials
https://www.readbyqxmd.com/read/29039638/a-citywide-assessment-of-oral-hygiene-needs-of-5-to-7-year-old-children
#17
Marjorie R Arnett, Bonnie Nelson, Erin Stephens
The purpose of this study was to assess the oral hygiene needs of 6,957 kindergarten and first-grade children enrolled in the San Bernardino City Unified School District. The findings from this study revealed that 9 percent of first-graders did not own a toothbrush, 15 percent shared a toothbrush and 25.3 percent self-reported mouth pain. In one school, 30 percent of the first-graders did not own a toothbrush and overall 38 percent of kindergarteners shared a toothbrush.
March 13, 2017: Journal of the California Dental Association
https://www.readbyqxmd.com/read/29038503/gastric-acid-suppression-promotes-alcoholic-liver-disease-by-inducing-overgrowth-of-intestinal-enterococcus
#18
Cristina Llorente, Peter Jepsen, Tatsuo Inamine, Lirui Wang, Sena Bluemel, Hui J Wang, Rohit Loomba, Jasmohan S Bajaj, Mitchell L Schubert, Masoumeh Sikaroodi, Patrick M Gillevet, Jun Xu, Tatiana Kisseleva, Samuel B Ho, Jessica DePew, Xin Du, Henrik T Sørensen, Hendrik Vilstrup, Karen E Nelson, David A Brenner, Derrick E Fouts, Bernd Schnabl
Chronic liver disease is rising in western countries and liver cirrhosis is the 12th leading cause of death worldwide. Simultaneously, use of gastric acid suppressive medications is increasing. Here, we show that proton pump inhibitors promote progression of alcoholic liver disease, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis in mice by increasing numbers of intestinal Enterococcus spp. Translocating enterococci lead to hepatic inflammation and hepatocyte death. Expansion of intestinal Enterococcus faecalis is sufficient to exacerbate ethanol-induced liver disease in mice...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29038260/meropenem-vaborbactam-resistance-selection-prevention-and-molecular-mechanisms-in-mutants-of-kpc-producing-klebsiella-pneumoniae
#19
Dongxu Sun, Debora Rubio-Aparicio, Kirk Nelson, Michael N Dudley, Olga Lomovskaya
Vaborbactam (formerly RPX7009) is a new beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniaecarbapenemases (KPC). It has been developed in combination with meropenem. The objective of these studies was to identify concentrations of both agents associated with selecting or preventing single-step mutations leading to reduced sensitivity to the combination, and to characterize the selected mutations. Eighteen strains of KPC-producing Klebsiella pneumoniae with varying degrees of sensitivity to meropenem (MIC 8-512 μg/ml) and meropenem-vaborbactam (≤0...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29038127/the-genital-tract-virulence-factor-pgp3-is-essential-for-chlamydia-muridarum-colonization-in-the-gastrointestinal-tract
#20
Lili Shao, Tianyuan Zhang, Jose Melero, Yumeng Huang, Yuanjun Liu, Quanzhong Liu, Cheng He, David E Nelson, Guangming Zhong
The cryptic plasmid is essential for Chlamydia muridarum dissemination from the genital tract to the gastrointestinal tract. Following intravaginal inoculation, C. muridarum deficient in plasmid-encoded pGP3 or 4, but not pGP5, 7 or 8, failed to spread to the mouse gastrointestinal tract, although mice infected with these strains developed productive genital tract infections. pGP3- or pGP4-deficient strains also failed to colonize the gastrointestinal tract when delivered intragastrically. pGP4 regulates pGP3, while pGP3 does not affect pGP4 expression, indicating that pGP3 is critical for C...
October 16, 2017: Infection and Immunity
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