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https://www.readbyqxmd.com/read/29474993/biomechanical-changes-and-recovery-of-gait-function-after-total-hip-arthroplasty-for-osteoarthritis-a-systematic-review-and-meta-analysis
#1
REVIEW
Jasvir S Bahl, Maximillian J Nelson, Mark Taylor, Lucian B Solomon, John B Arnold, Dominic Thewlis
OBJECTIVE: To determine the change in walking gait biomechanics after total hip arthroplasty (THA) for osteoarthritis (OA) compared to the pre-operative gait status, and to compare the recovery of gait following THA with healthy individuals. METHODS: Systematic review with meta-analysis of studies investigating changes in gait biomechanics after THA compared to (1) preoperative levels and (2) healthy individuals. Data were pooled at commonly reported time points and standardised mean differences (SMDs) were calculated in meta-analyses for spatiotemporal, kinematic and kinetic parameters...
February 20, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29474662/radiographic-analysis-of-the-vidian-canal-and-its-utility-in-petrous-internal-carotid-artery-localization
#2
Eric C Mason, Patricia A Hudgins, Gustavo Pradilla, Nelson M Oyesiku, C Arturo Solares
BACKGROUND: Endoscopic endonasal surgery of the skull base requires expert knowledge of the anatomy and a systematic approach. The vidian canal is regarded as a reliable landmark to localize the petrous internal carotid artery (pICA) near the second genu, which can be used for orientation in deep skull base approaches. There is controversy about the relationship between the vidian canal and the pICA. OBJECTIVE: To further establish the vertical relationship between the vidian canal and the pICA to aid in surgical approaches to the skull base...
February 21, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29474529/epic-coge-managing-and-analyzing-genomic-data
#3
Andrew D L Nelson, Asher K Haug-Baltzell, Sean Davey, Brian D Gregory, Eric Lyons
Summary: The EPIC-CoGe browser is a web-based genome visualization utility that integrates the GMOD JBrowse genome browser with the extensive CoGe genome database (currently containing over 30,000 genomes). In addition, the EPIC-CoGe browser boasts many additional features over basic JBrowse, including enhanced search capability and on-the-fly analyses for comparisons and analyses between all types of functional and diversity genomics data. There is no installation required and data (genome, annotation, functional genomic, and diversity data) can be loaded by following a simple point and click wizard, or using a REST API, making the browser widely accessible and easy to use by researchers of all computational skill levels...
February 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29474461/distinct-susceptibility-of-hiv-vaccine-vector-induced-cd4-t-cells-to-hiv-infection
#4
Sarah Auclair, Fengliang Liu, Qingli Niu, Wei Hou, Gavin Churchyard, Cecilia Morgan, Nicole Frahm, Sorachai Nitayaphan, Punnee Pitisuthithum, Supachai Rerks-Ngarm, Jason T Kimata, Lynn Soong, Genoveffa Franchini, Merlin Robb, Jerome Kim, Nelson Michael, Haitao Hu
The concerns raised from adenovirus 5 (Ad5)-based HIV vaccine clinical trials, where excess HIV infections were observed in some vaccine recipients, have highlighted the importance of understanding host responses to vaccine vectors and the HIV susceptibility of vector-specific CD4 T cells in HIV vaccination. Our recent study reported that human Ad5-specific CD4 T cells induced by Ad5 vaccination (RV156A trial) are susceptible to HIV. Here we further investigated the HIV susceptibility of vector-specific CD4 T cells induced by ALVAC, a canarypox viral vector tested in the Thai trial RV144, as compared to Ad5 vector-specific CD4 T cells in the HVTN204 trial...
February 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29474371/correction-antibiotic-resistance-rates-and-physician-antibiotic-prescription-patterns-of-uncomplicated-urinary-tract-infections-in-southern-chinese-primary-care
#5
Carmen Ka Man Wong, Kenny Kung, Philip Lung Wai Au-Doung, Margaret Ip, Nelson Lee, Alice Fung, Samuel Yeung Shan Wong
[This corrects the article DOI: 10.1371/journal.pone.0177266.].
2018: PloS One
https://www.readbyqxmd.com/read/29474071/identification-of-gibberellic-acid-derivatives-that-deregulate-cholesterol-metabolism-in-prostate-cancer-cells
#6
Folake A Egbewande, Martin C Sadowski, Claire Levrier, Kaylyn D Tousignant, Jonathan M White, Mark J Coster, Colleen C Nelson, Rohan A Davis
The naturally occurring pentacyclic diterpenoid gibberellic acid (1) was used in the generation of a drug-like amide library using parallel-solution-phase synthesis. Prior to the synthesis, a virtual library was generated and prioritized based on drug-like physicochemical parameters such as log P, hydrogen bond donor/acceptor counts, and molecular weight. The structures of the synthesized analogues (2-13) were elucidated following analysis of the NMR, MS, UV, and IR data. Compound 12 afforded crystalline material, and its structure was confirmed by X-ray crystallographic analysis...
February 23, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29473245/does-training-people-to-administer-take-home-naloxone-increase-their-knowledge-evidence-from-australian-programs
#7
Paul M Dietze, Bridget Draper, Anna Olsen, Karen J Chronister, Ingrid van Beek, Nicholas Lintzeris, Robyn Dwyer, Marina Nelson, Simon Lenton
INTRODUCTION AND AIMS: Take-home naloxone (THN) programs have been operating in Australia since 2012 in a variety of settings. We examine whether THN programs were effective in increasing knowledge about opioid overdose and appropriate responses in program participants. DESIGN AND METHODS: Data were obtained from pre- and post-training questionnaires administered as part of the early evaluations of THN naloxone programs operated in Sydney (n = 67), Melbourne (n = 280), Perth (n = 153) and Canberra (n = 183)...
February 22, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29473172/ceftriaxone-induced-drug-reaction-mimicking-acute-splenic-sequestration-crisis-in-a-child-with-hemoglobin-sc-disease
#8
Nancy L Van Buren, Jed B Gorlin, Robyn C Reed, Jerome L Gottschall, Stephen C Nelson
BACKGROUND: Acute splenic sequestration crisis is a complication of sickle cell disease (SCD) occurring when intrasplenic red blood cell (RBC) sickling prevents blood from leaving the spleen, causing acute splenic enlargement. Although typically seen in young children, it has been reported in older children with hemoglobin (Hb)SC disease, eventually resulting in functional asplenia. Ceftriaxone is a frequently used antibiotic of choice for children with SCD, because of its efficacy against invasive pneumococcal disease...
February 22, 2018: Transfusion
https://www.readbyqxmd.com/read/29473051/ap4-deficiency-a-novel-form-of-neurodegeneration-with-brain-iron-accumulation
#9
Agathe Roubertie, Nelson Hieu, Charles-Joris Roux, Nicolas Leboucq, Gael Manes, Majida Charif, Bernard Echenne, Cyril Goizet, Claire Guissart, Pierre Meyer, Cecilia Marelli, François Rivier, Lydie Burglen, Rita Horvath, Christian P Hamel, Guy Lenaers
Objective: To describe the clinico-radiological phenotype of 3 patients harboring a homozygous novel AP4M1 pathogenic mutation. Methods: The 3 patients from an inbred family who exhibited early-onset developmental delay, tetraparesis, juvenile motor function deterioration, and intellectual deficiency were investigated by magnetic brain imaging using T1-weighted, T2-weighted, T2*-weighted, fluid-attenuated inversion recovery, susceptibility weighted imaging (SWI) sequences...
February 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29472515/development-of-a-standardized-approach-for-managing-opioids-in-adults-with-chronic-noncancer-pain
#10
Jessica M Downes, Donald G Klepser, Jennifer Foster, Maggie Nelson
PURPOSE: The implementation of a chronic pain protocol (CPP) and its effects on the management of long-term opioid therapy are described. SUMMARY: The CPP used at a federally qualified health center and primary care clinic was updated in 2015 and included a prescribing ceiling in morphine equivalent dose (MED) per day and standardized the prescribing of chronic opioids. Intermittent urine drug screening performed at least once annually was added as a requirement of the pain management contract between the provider and the patient...
March 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29471733/the-influence-of-lotteries-on-employees-workplace-hiv-testing-behaviour
#11
Martin Weihs, Anna Meyer-Weitz, Friederike Baasner-Weihs
The aim of the study was to understand how lottery incentives influenced the HIV counselling and testing (HCT) behaviour and behaviour intention of shop-floor workers who participated in a workplace HCT campaign initiative in two companies in the Nelson Mandela Bay municipality, South Africa. A post-test only quasi-experimental approach was used. The data were first collected, using a self-administered cross-sectional survey instrument, among the control group (n = 88) followed by the experimental group (n = 110) after the advent of HIV testing and lotteries was announced...
February 22, 2018: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29471254/uplc-ms-ms-assay-validation-for-tacrolimus-quantitative-determination-in-peripheral-blood-t-cd4-and-b-cd19-lymphocytes
#12
Paschoalina Romano, Maria da Luz Fernandes, Pérsio de Almeida Rezende Ebner, Nayara Duarte de Oliveira, Larissa Mitsue Okuda, Fabiana Agena, Maria Elizabete Mendes, Nairo Massakazu Sumita, Verônica Coelho, Elias David-Neto, Nelson Zocoler Galante
Monitoring tacrolimus (Tac) exposure in cell matrices enriched with lymphocytes can improve Tac therapeutic drug monitoring (TDM) in solid organ transplant recipients. An UPLC-MS/MS based assay for Tac quantification in peripheral blood T CD4+ and B CD19+ lymphocytes was developed. Peripheral blood mononuclear cells (PBMC) were obtained by density gradient centrifugation and highly purified (purity >90%) T CD4+ and B CD19+ cell suspensions were acquired by magnetic negative selection from whole blood of 6 healthy volunteers...
January 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29470937/renal-lesion-characterization-with-spectral-ct-determining-the-optimal-energy-for-virtual-monoenergetic-reconstruction
#13
Christoph Schabel, Bhavik Patel, Scott Harring, Petar Duvnjak, Juan Carlos Ramírez-Giraldo, Konstantin Nikolaou, Rendon C Nelson, Alfredo E Farjat, Daniele Marin
Purpose To investigate the relationship between energy level of virtual monoenergetic (VM) imaging and sensitivity in the detection of minimally enhancing renal lesions. Materials and Methods Phantoms simulating unenhanced and contrast material-enhanced renal parenchyma were equipped with inserts containing different concentrations of iodine (range, 0-1.15 mg iodine per milliliter). A total of 180 patients (117 men; mean age, 65.2 years ± 13.0 [standard deviation]) with 194 (62 solid, 132 cystic) renal lesions larger than 10 mm in diameter underwent unenhanced single-energy CT and contrast-enhanced dual-energy CT...
February 22, 2018: Radiology
https://www.readbyqxmd.com/read/29470382/a-tool-to-identify-key-behaviors-and-attributes-of-high-performing-nurses
#14
Linda B Cain, Sherill Nones Cronin, Debbie Nelson, Darla A Meredith, Karen Profitt Newman, Steven Rudolf
OBJECTIVE: The purpose of this project was to identify key behaviors and attributes that distinguish high-performing nurses to develop a tool for employment screening, staff development, and performance management. BACKGROUND: Selecting nurses who will complement an organization's mission and philosophy is a key step toward achieving quality and safety goals, ensuring patient and family satisfaction, and improving retention rates and overall costs. METHODS: Focus group methodology was used to determine perceptions of high-performing nurses' behaviors and attributes...
February 21, 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29470208/the-cdc-s-hi-5-initiative
#15
Roxanne Nelson
A plan to improve community health in five years.
March 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29469957/the-effect-of-urine-concentration-and-ph-on-the-growth-of-escherichia-coli-in-canine-urine-in-vitro
#16
L A Thornton, R K Burchell, S E Burton, N Lopez-Villalobos, D Pereira, I MacEwan, C Fang, A C Hatmodjo, M A Nelson, A Grinberg, N Velathanthiri, A Gal
BACKGROUND: Lower urinary tract infections are common in dogs, and Escherichia coli is the most common bacterial pathogen isolated. The literature has conflicting evidence regarding the inhibitory effects of urine concentration and pH on E. coli growth. HYPOTHESIS/OBJECTIVES: To determine the effect of different pH and urine concentrations on E. coli growth in vitro. ANIMALS: Voided urine samples from 10 apparently healthy spayed female dogs were used...
February 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29469720/erythema-multiforme-major-in-a-patient-with-metastatic-melanoma-treated-with-nivolumab
#17
Swami Sundaresan, Kathleen T Nguyen, Kelly C Nelson, Doina Ivan, Anisha B Patel
Nivolumab, a relatively novel immune checkpoint inhibitor with FDA approval in 2014, is gaining greater utilization due to its efficacy in treating metastatic melanoma. Many of the cutaneous immune-related adverse events (irAEs) being catalogued do not necessitate discontinuation of immunotherapy and are managed with supportive therapy. We present a case of erythema multiforme major secondary to nivolumab requiring hospitalization and discontinuation of treatment. This is only the second reported case of nivolumab-induced erythema multiforme in the literature we are aware of, and emphasizes the importance of oncologists working in conjunction with dermatologists for prompt diagnosis and management...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29467823/in-vitro-and-in-vivo-characterization-of-three-cellvibrio-japonicus-glycoside-hydrolase-family-5-members-reveals-potent-xyloglucan-backbone-cleaving-functions
#18
Mohamed A Attia, Cassandra E Nelson, Wendy A Offen, Namrata Jain, Gideon J Davies, Jeffrey G Gardner, Harry Brumer
Background: Xyloglucan (XyG) is a ubiquitous and fundamental polysaccharide of plant cell walls. Due to its structural complexity, XyG requires a combination of backbone-cleaving and sidechain-debranching enzymes for complete deconstruction into its component monosaccharides. The soil saprophyte Cellvibrio japonicus has emerged as a genetically tractable model system to study biomass saccharification, in part due to its innate capacity to utilize a wide range of plant polysaccharides for growth...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29467506/a-thirst-for-advancement
#19
Benjamin S Hsiao, Samuel Chigome, Nelson Torto
No abstract text is available yet for this article.
March 2018: Nature Materials
https://www.readbyqxmd.com/read/29467462/hipsc-derived-neural-stem-cells-from-patients-with-schizophrenia-induce-an-impaired-angiogenesis
#20
Bárbara S Casas, Gabriela Vitória, Marcelo N do Costa, Rodrigo Madeiro da Costa, Pablo Trindade, Renata Maciel, Nelson Navarrete, Stevens K Rehen, Verónica Palma
Schizophrenia is a neurodevelopmental disease characterized by cerebral connectivity impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) that concentration of VEGFA, a master angiogenic factor, is decreased. Recent evidence suggests cerebral hypoperfusion related to a dysfunctional Blood Brain Barrier (BBB) in SZP. Since neurogenesis and blood-vessel formation occur in a coincident and coordinated fashion, a defect in neurovascular development could result in increased vascular permeability and, therefore, in poor functionality of the SZP's neurons...
February 22, 2018: Translational Psychiatry
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