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https://www.readbyqxmd.com/read/28895013/non-donors-attitudes-towards-sperm-donation-and-their-willingness-to-donate
#1
Veerle Provoost, Florence Van Rompuy, Guido Pennings
PURPOSE: The aim of this article is to study attitudes about sperm donation and willingness to donate sperm in students who have never shown an interest in sperm donation. METHODS: The method used in this study is an electronic survey of 1012 male students. RESULTS: Only one third of the respondents (34.3%) would consider donating sperm. Overall, 85.7% indicated a positive attitude towards sperm donation while 14.3% indicated a neutral or negative attitude...
September 11, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28865553/motivations-and-attitudes-of-candidate-sperm-donors-in-belgium
#2
Annelies Thijssen, Veerle Provoost, Eva Vandormael, Nathalie Dhont, Guido Pennings, Willem Ombelet
OBJECTIVE: To study the motivation and attitudes of a candidate sperm donor population in Belgium. DESIGN: Anonymous survey. SETTING: Tertiary referral infertility center. PATIENT(S): One hundred candidate sperm donors applying to the center for a first semen analysis between April 2013 and March 2016. INTERVENTION(S): Invitation to complete an anonymous questionnaire. MAIN OUTCOME MEASURE(S): Demographic characteristics, recruitment methods, motivations and attitudes toward payment, donor anonymity, disclosure to offspring, donation to lesbian couples and single women, views on the donor children and social aspects of sperm donation...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28857843/altruistic-nondirected-kidney-donation-attitudes-characteristics-and-ethical-implications
#3
Maja Ehlers, Frank Vitinius, Michael Langenbach
PURPOSE OF REVIEW: Altruistic nondirected kidney donation involves a person donating one of their kidneys to an unknown recipient. The donor's mental health and motives are frequently questioned. We want to highlight this topic and also encourage discussions about ethical implications. RECENT FINDINGS: The main topics are the mental health of altruistic nondirected kidney donors and the general attitude towards the practice of this form of donation as well as the willingness of the public to donate this way...
August 28, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28841764/how-do-people-become-plasma-and-platelet-donors-in-a-vnr-context
#4
Johanne Charbonneau, Marie-Soleil Cloutier, Balia Fainstein
BACKGROUND: The demand for therapeutic plasma-derived products poses a challenge to blood collection agencies (BCAs). In 2014-2015, the volume of plasma sent for fractionation met 17.7% of Quebec's needs for immunoglobulins. This article aims to offer an exploration of the paths blood donors follow in order to become plasma and platelet donors (PPDs). STUDY DESIGN AND METHOD: This analysis is based on semi-structured interviews with 50 PPDs in Quebec, Canada. Our analysis focused on the occurrence of events and the presence of contextual elements identified through: (1) factual data on PPDs; and (2) what PPDs identified as being an influence on their donation experience...
August 25, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28803004/-just-blood-donors-a-study-on-the-multi-affiliations-of-blood-donors
#5
Sara Alfieri, Maura Pozzi, Elena Marta, Vincenzo Saturni, Giovanni Aresi, Paolo Guiddi
BACKGROUND: The present work proposes to explore a phenomenon well known in the world of blood donation, but little explored by literature: multi-affiliations. By that term, in this paper we mean blood donors' engagement in multiple associations of various natures (donation, recreation, sports, etc.) simultaneously. The first objective proposes to explore the phenomenon of multi-affiliations in descriptive terms; the second is to look into the differences-in terms of motivations, family-work-volunteerism reconciliation, life satisfaction, and membership satisfaction-between those who "only" carry out blood donation activity and those who instead participate in multiple associative realities concurrently...
July 25, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28795746/pt-dipyridyl-tetrazine-metal-organic-network-on-the-au-100-surface-insights-from-first-principles-calculations
#6
Duy Le, Talat S Rahman
Metal-organic coordination networks with active metal centers are a promising class of materials for next-generation catalysts. Motivated by experimental observations of the formation of a Pt-Dipyridyl Tetrazine (DT) metal-organic network on the Au(100) surface [D. Skomski et al., J. Am. Chem. Soc., 2014, 136, 9862], we carried out density functional theory based calculations on the same system. In this discussion, we demonstrate that the strong interaction between DT ligands and Pt metal centers makes the network stable and that the Pt centers become positively charged by donating their electrons to the DT ligands, resulting in +2 oxidation states for the Pt centers...
August 10, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28777537/pushing-chemical-boundaries-with-n-heterocyclic-olefins-nhos-from-catalysis-to-main-group-element-chemistry
#7
Matthew M D Roy, Eric Rivard
N-Heterocyclic olefins (NHOs) have gone from the topic of a few scattered (but important) reports in the early 1990s to very recently being a ligand/reagent of choice in the far-reaching research fields of organocatalysis, olefin and heterocycle polymerization, and low oxidation state main group element chemistry. NHOs are formally derived by appending an alkylidene (CR2) unit onto an N-heterocyclic carbene (NHC), and their pronounced ylidic character leads to high nucleophilicity and soft Lewis basic character at the ligating carbon atom...
August 4, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28766619/magnetic-circular-dichroism-and-density-functional-theory-studies-of-electronic-structure-and-bonding-in-cobalt-ii-n-heterocyclic-carbene-complexes
#8
Theresa E Iannuzzi, Yafei Gao, Tessa M Baker, Liang Deng, Michael L Neidig
The combination of simple cobalt salts and N-heterocyclic carbene (NHC) ligands has been highly effective in C-H functionalization, hydroarylation and cross-coupling catalysis, though displaying a strong dependence on the identity of the NHC ligand. In addition, reactions effective with NHC ligands are often ineffective with phosphine ligands, further motivating the evaluation of the fundamental electronic structure and bonding differences in well-defined distorted tetrahedral Co(ii) complexes. Magnetic circular dichroism (MCD) studies indicate that Co(ii)-bisphosphines have larger ligand fields than Co(ii)-NHC complexes...
August 2, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28750535/evaluation-of-dna-methyltransferase-activity-and-inhibition-via-isothermal-enzyme-free-concatenated-hybridization-chain-reaction
#9
Qing Wang, Min Pan, Jie Wei, Xiaoqing Liu, Fuan Wang
Methyltransferase (MTase)-catalyzed DNA methylation plays a vital role in the biological epigenetic processes of key diseases and has attracted increasing attention, making the amplified detection of MTase activity of great significance in clinical disease diagnosis and treatment. Herein, we developed an isothermal, enzyme-free, and autonomous strategy for analyzing MTase activity based on concatenated hybridization chain reaction (C-HCR)-mediated Förster resonance energy transfer (FRET). In a typical C-HCR procedure without MTase (Dam), Y-shaped initiator DNA activates upstream HCR-1 to assemble a double-stranded DNA (dsDNA) copolymeric nanowire consisting of multiple tandem DNA trigger units that motivate downstream HCR-2 to successively bring a fluorophore donor/acceptor (FAM/TAMRA) pair into close proximity, leading to the generation of an amplified FRET readout signal...
July 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28712934/donor-lymphocyte-infusions-used-to-treat-mixed-chimeric-and-high-risk-patient-populations-in-the-relapsed-and-nonrelapsed-settings-after-allogeneic-transplantation-for-hematologic-malignancies-are-associated-with-high-five-year-survival-if-persistent-full-donor
#10
Lauren E Caldemeyer, Luke P Akard, John R Edwards, Anand Tandra, Dawn R Wagenknecht, Michael J Dugan
Mixed chimerism (MC), a persistent or increasing number of host cells after allogeneic hematopoietic stem cell transplantation (HSCT), is a predictor of disease relapse. Donor lymphocyte infusions (DLI) have the potential to enhance the graft-versus-malignancy (GVM) effect, reducing the risk of relapse in patients with MC. Hence, in addition to utilizing DLI in the relapsed setting, there is a motivation to pursue pre-emptive DLI for patients in complete remissions after HSCT. To assess the safety and efficacy of DLI, records of 86 patients who received DLI between 2003 and 2015 at a single institution were studied retrospectively...
July 13, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28686202/coinage-metal-complexes-of-the-carbenic-tautomer-of-a-conjugated-mesomeric-betaine-akin-to-nitron
#11
Charlotte Thie, Clemens Bruhn, Michael Leibold, Ulrich Siemeling
This study was motivated by our recent observation that the analytical reagent Nitron (2) is an "instant carbene", whose reaction with coinage metal salts MX afforded complexes of its carbenic tautomer 1,4-diphenyl-3-phenylamino-1,2,4-triazol-5-ylidene (2'). Our aim was to establish an alkyl homologue of 2 in order to achieve a carbenic tautomer of higher donicity. For this purpose 1-tert-butyl-4-methyl-1,2,4-triazol-4-ium-3-tert-butylaminide (6) was synthesized. Its reactions with MX afforded complexes of the carbenic tautomer 1-tert-butyl-3-tert-butylamino-4-methyl-1,2,4-triazol-5-ylidene (6')...
July 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28686151/individual-contextual-and-network-characteristics-of-blood-donors-and-non-donors-a-systematic-review-of-recent-literature
#12
REVIEW
Tjeerd W Piersma, René Bekkers, Elisabeth F Klinkenberg, Wim L A M De Kort, Eva-Maria Merz
BACKGROUND: The ageing population and recent migration flows may negatively affect the blood supply in the long term, increasing the importance of targeted recruitment and retention strategies to address donors. This review sought to identify individual, network and contextual characteristics related to blood donor status and behaviour, to systematically discuss differences between study results, and to identify possible factors to target in recruitment and retention efforts. METHODS: The systematic review was conducted in accordance with a predefined PROSPERO protocol (CRD42016039591)...
September 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28683736/security-controls-in-an-integrated-biobank-to-protect-privacy-in-data-sharing-rationale-and-study-design
#13
Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura, Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi, Shigeo Kure, Gen Tamiya, Yoshio Kawaguchi, Hiroshi Tanaka, Masayuki Yamamoto
BACKGROUND: With the goal of realizing genome-based personalized healthcare, we have developed a biobank that integrates personal health, genome, and omics data along with biospecimens donated by volunteers of 150,000. Such a large-scale of data integration involves obvious risks of privacy violation. The research use of personal genome and health information is a topic of global discussion with regard to the protection of privacy while promoting scientific advancement. The present paper reports on our plans, current attempts, and accomplishments in addressing security problems involved in data sharing to ensure donor privacy while promoting scientific advancement...
July 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28681588/response-of-linear-and-cyclic-electron-flux-to-moderate-high-temperature-and-high-light-stress-in-tomato
#14
Tao Lu, Jie-Wei Shi, Zhou-Ping Sun, Ming-Fang Qi, Yu-Feng Liu, Tian-Lai Li
OBJECTIVE: To evaluate the possible photoprotection mechanisms of cyclic and linear electron flux (CEF and LEF) under specific high temperature and high light (HH) stress. METHODS: Six-leaf-stage tomato seedlings ("Liaoyuanduoli", n=160) were divided into four parts: Part 1, served as control under 25 °C, 500 µmol/(m(2)·s); Part 2, spayed with distilled water (H2O) under 35 °C, 1000 µmol/(m(2)·s) (HH); Part 3, spayed with 100 µmol/L diuron (DCMU, CEF inhibitor) under HH; Part 4, spayed with 60 µmol/L methyl viologen (MV, LEF inhibitor) under HH...
July 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28671899/clinicians-perception-and-experience-of-organ-donation-from-brain-dead-patients
#15
Nancy Kentish-Barnes, Jacques Duranteau, Claire Montlahuc, Julien Charpentier, Laurent Martin-Lefevre, Liliane Joseph, Jean-Yves Lefrant, Fabienne Fieux, Anne Renault, Marie Thuong, Sylvie Chevret, Elie Azoulay
OBJECTIVE: ICU clinicians are primarily involved in organ donation after brain death of ICU patients. Their perceptions of organ donation may affect outcomes. Our objective was to describe ICU clinician's perceptions and experience of organ donation. DESIGN AND SETTING: Cross-sectional study among physicians and nurses (90 ICUs in France). We used factorial correspondence analysis to describe categories of clinicians regarding their perceptions and experience of organ donation...
September 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28671313/context-and-social-perceptions-of-blood-donation-in-donors-found-positive-for-human-immunodeficiency-virus-in-france
#16
Alice Duquesnoy, Bruno Danic, Aurélie Santos, Christophe Martinaud, Geneviève Woimant, Syria Laperche, Pierre Tiberghien, Marie Jauffret-Roustide, Josiane Pillonel
BACKGROUND: In France, information collected during postdonation interviews showed that a majority of human immunodeficiency virus (HIV)-infected donors were not eligible to donate as per donor selection criteria. In the interest of blood safety, this study aimed to explore the mechanisms of noncompliance with blood donor selection criteria, notably the permanent deferral of men who have sex with men (MSM). STUDY DESIGN AND METHODS: Semistructured individual interviews were conducted with 32 blood donors found positive for HIV between mid-2011 and 2014...
July 3, 2017: Transfusion
https://www.readbyqxmd.com/read/28671277/a-motivational-interview-promotes-retention-of-blood-donors-with-high-internal-motivation
#17
Christopher R France, Janis L France, Bruce W Carlson, Lina K Himawan, Debra A Kessler, Mark Rebosa, Beth H Shaz, Katrala Madden, Patricia M Carey, P Maxwell Slepian, Brett Ankawi, Irina E Livitz, Kristen R Fox
BACKGROUND: Based on the hypothesis that self-determined motivation is associated with an increased likelihood of future behavior, the present study examined the ability of a motivational interview to promote internal motivation for giving blood and future donation attempts. STUDY DESIGN AND METHODS: A sample of 484 recent whole-blood and double red blood cell donors (62.4% female; age = 30.2 ± 11.8 years) were randomly assigned to either a telephone-delivered motivational interview or a control call approximately 6 weeks after donating...
July 3, 2017: Transfusion
https://www.readbyqxmd.com/read/28655844/demotivating-incentives-and-motivation-crowding-out-in-charitable-giving
#18
Matthew Chao
Research has shown that extrinsic incentives can crowd out intrinsic motivation in many contexts. Despite this, many nonprofits offer conditional thank-you gifts, such as mugs or tote bags, in exchange for donations. In collaboration with a nonprofit, this study implements a direct mail field experiment and demonstrates that thank-you gifts reduced donation rates in a fundraising campaign. Attention-based multiattribute choice models suggest that this is because prospective donors shift attention to the salient gift offer, causing them to underweight less salient intrinsic motives...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28586527/generation-of-the-membrane-potential-and-its-impact-on-the-motility-atp-production-and-growth-in-campylobacter-jejuni
#19
Anne-Xander van der Stel, Fred C Boogerd, Steven Huynh, Craig T Parker, Linda van Dijk, Jos P M van Putten, Marc M S M Wösten
The generation of a membrane potential (Δψ), the major constituent of the proton motive force (pmf), is crucial for ATP synthesis, transport of nutrients and flagellar rotation. Campylobacter jejuni harbors a branched electron transport chain, enabling respiration with different electron donors and acceptors. Here, we demonstrate that a relatively high Δψ is only generated in the presence of either formate as electron donor or oxygen as electron acceptor, in combination with an acceptor/donor respectively...
June 6, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28579040/autonomy-and-self-esteem-of-women-who-donate-to-an-oocyte-cryopreservation-bank-in-the-netherlands
#20
Marjolein R Bakker, Joyce Maas, Marrie H Bekker, Annelien L Bredenoord, Bart C Fauser, Annelies M Bos
Worldwide, oocyte donors donate voluntarily or receive varying amounts of money for donation. This raises ethical questions regarding the appropriateness of financial compensation, and the possibility of undue inducement and exploitation of oocyte donors. Are these donors capable of making an independent, well-considered decision? Regarding this matter, it is important to examine aspects such as autonomy-connectedness and self-esteem. In this cross-sectional study, demographic characteristics and donation motivations were assessed in 92 women who attended the University Medical Center (UMC) Utrecht as potential oocyte donors between June 2012 and July 2016...
May 17, 2017: Reproductive Biomedicine Online
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