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https://www.readbyqxmd.com/read/28712934/donor-lymphocyte-infusions-used-to-treat-mixed-chimeric-and-high-risk-patient-populations-in-the-relapsed-and-non-relapsed-settings-after-allogeneic-transplant-for-hematologic-malignancies-are-associated-with-high-5-year-survival-if-persistent-full-donor-chimerism
#1
Lauren E Caldemeyer, Luke P Akard, John R Edwards, Anand Tandra, Dawn R Wagenknecht, Michael J Dugan
Mixed chimerism (MC), a persistent or increasing number of host cells after allogeneic hematopoietic stem cell transplant (HSCT), is a predictor of disease relapse. Donor lymphocyte infusions (DLI) have the potential to enhance the graft vs. malignancy (GvM) effect, reducing the risk of relapse in patients with MC. Hence, in addition to utilizing DLI in the relapsed setting, there is a motivation to pursue pre-emptive DLI for patients in complete remissions (CR) after HSCT. To assess the safety and efficacy of DLI, records of 86 patients who received DLI between 2003 and 2015 at a single institution were studied retrospectively...
July 13, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28686202/coinage-metal-complexes-of-the-carbenic-tautomer-of-a-conjugated-mesomeric-betaine-akin-to-nitron
#2
Charlotte Thie, Clemens Bruhn, Michael Leibold, Ulrich Siemeling
This study was motivated by our recent observation that the analytical reagent Nitron (2) is an "instant carbene", whose reaction with coinage metal salts MX afforded complexes of its carbenic tautomer 1,4-diphenyl-3-phenylamino-1,2,4-triazol-5-ylidene (2'). Our aim was to establish an alkyl homologue of 2 in order to achieve a carbenic tautomer of higher donicity. For this purpose 1-tert-butyl-4-methyl-1,2,4-triazol-4-ium-3-tert-butylaminide (6) was synthesized. Its reactions with MX afforded complexes of the carbenic tautomer 1-tert-butyl-3-tert-butylamino-4-methyl-1,2,4-triazol-5-ylidene (6')...
July 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28686151/individual-contextual-and-network-characteristics-of-blood-donors-and-non-donors-a-systematic-review-of-recent-literature
#3
REVIEW
Tjeerd W Piersma, René Bekkers, Elisabeth F Klinkenberg, Wim L A M De Kort, Eva-Maria Merz
BACKGROUND: The ageing population and recent migration flows may negatively affect the blood supply in the long term, increasing the importance of targeted recruitment and retention strategies to address donors. This review sought to identify individual, network and contextual characteristics related to blood donor status and behaviour, to systematically discuss differences between study results, and to identify possible factors to target in recruitment and retention efforts. METHODS: The systematic review was conducted in accordance with a predefined PROSPERO protocol (CRD42016039591)...
June 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28683736/security-controls-in-an-integrated-biobank-to-protect-privacy-in-data-sharing-rationale-and-study-design
#4
Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura, Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi, Shigeo Kure, Gen Tamiya, Yoshio Kawaguchi, Hiroshi Tanaka, Masayuki Yamamoto
BACKGROUND: With the goal of realizing genome-based personalized healthcare, we have developed a biobank that integrates personal health, genome, and omics data along with biospecimens donated by volunteers of 150,000. Such a large-scale of data integration involves obvious risks of privacy violation. The research use of personal genome and health information is a topic of global discussion with regard to the protection of privacy while promoting scientific advancement. The present paper reports on our plans, current attempts, and accomplishments in addressing security problems involved in data sharing to ensure donor privacy while promoting scientific advancement...
July 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28681588/response-of-linear-and-cyclic-electron-flux-to-moderate-high-temperature-and-high-light-stress-in-tomato
#5
Tao Lu, Jie-Wei Shi, Zhou-Ping Sun, Ming-Fang Qi, Yu-Feng Liu, Tian-Lai Li
OBJECTIVE: To evaluate the possible photoprotection mechanisms of cyclic and linear electron flux (CEF and LEF) under specific high temperature and high light (HH) stress. METHODS: Six-leaf-stage tomato seedlings ("Liaoyuanduoli", n=160) were divided into four parts: Part 1, served as control under 25 °C, 500 µmol/(m(2)·s); Part 2, spayed with distilled water (H2O) under 35 °C, 1000 µmol/(m(2)·s) (HH); Part 3, spayed with 100 µmol/L diuron (DCMU, CEF inhibitor) under HH; Part 4, spayed with 60 µmol/L methyl viologen (MV, LEF inhibitor) under HH...
July 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28671899/clinicians-perception-and-experience-of-organ-donation-from-brain-dead-patients
#6
Nancy Kentish-Barnes, Jacques Duranteau, Claire Montlahuc, Julien Charpentier, Laurent Martin-Lefevre, Liliane Joseph, Jean-Yves Lefrant, Fabienne Fieux, Anne Renault, Marie Thuong, Sylvie Chevret, Elie Azoulay
OBJECTIVE: ICU clinicians are primarily involved in organ donation after brain death of ICU patients. Their perceptions of organ donation may affect outcomes. Our objective was to describe ICU clinician's perceptions and experience of organ donation. DESIGN AND SETTING: Cross-sectional study among physicians and nurses (90 ICUs in France). We used factorial correspondence analysis to describe categories of clinicians regarding their perceptions and experience of organ donation...
June 30, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28671313/context-and-social-perceptions-of-blood-donation-in-donors-found-positive-for-human-immunodeficiency-virus-in-france
#7
Alice Duquesnoy, Bruno Danic, Aurélie Santos, Christophe Martinaud, Geneviève Woimant, Syria Laperche, Pierre Tiberghien, Marie Jauffret-Roustide, Josiane Pillonel
BACKGROUND: In France, information collected during postdonation interviews showed that a majority of human immunodeficiency virus (HIV)-infected donors were not eligible to donate as per donor selection criteria. In the interest of blood safety, this study aimed to explore the mechanisms of noncompliance with blood donor selection criteria, notably the permanent deferral of men who have sex with men (MSM). STUDY DESIGN AND METHODS: Semistructured individual interviews were conducted with 32 blood donors found positive for HIV between mid-2011 and 2014...
July 3, 2017: Transfusion
https://www.readbyqxmd.com/read/28671277/a-motivational-interview-promotes-retention-of-blood-donors-with-high-internal-motivation
#8
Christopher R France, Janis L France, Bruce W Carlson, Lina K Himawan, Debra A Kessler, Mark Rebosa, Beth H Shaz, Katrala Madden, Patricia M Carey, P Maxwell Slepian, Brett Ankawi, Irina E Livitz, Kristen R Fox
BACKGROUND: Based on the hypothesis that self-determined motivation is associated with an increased likelihood of future behavior, the present study examined the ability of a motivational interview to promote internal motivation for giving blood and future donation attempts. STUDY DESIGN AND METHODS: A sample of 484 recent whole-blood and double red blood cell donors (62.4% female; age = 30.2 ± 11.8 years) were randomly assigned to either a telephone-delivered motivational interview or a control call approximately 6 weeks after donating...
July 3, 2017: Transfusion
https://www.readbyqxmd.com/read/28655844/demotivating-incentives-and-motivation-crowding-out-in-charitable-giving
#9
Matthew Chao
Research has shown that extrinsic incentives can crowd out intrinsic motivation in many contexts. Despite this, many nonprofits offer conditional thank-you gifts, such as mugs or tote bags, in exchange for donations. In collaboration with a nonprofit, this study implements a direct mail field experiment and demonstrates that thank-you gifts reduced donation rates in a fundraising campaign. Attention-based multiattribute choice models suggest that this is because prospective donors shift attention to the salient gift offer, causing them to underweight less salient intrinsic motives...
June 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28586527/generation-of-the-membrane-potential-and-its-impact-on-the-motility-atp-production-and-growth-in-campylobacter-jejuni
#10
Anne-Xander van der Stel, Fred C Boogerd, Steven Huynh, Craig T Parker, Linda van Dijk, Jos P M van Putten, Marc M S M Wösten
The generation of a membrane potential (Δψ), the major constituent of the proton motive force (pmf), is crucial for ATP synthesis, transport of nutrients and flagellar rotation. Campylobacter jejuni harbors a branched electron transport chain, enabling respiration with different electron donors and acceptors. Here, we demonstrate that a relatively high Δψ is only generated in the presence of either formate as electron donor or oxygen as electron acceptor, in combination with an acceptor/donor, respectively...
June 6, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28579040/autonomy-and-self-esteem-of-women-who-donate-to-an-oocyte-cryopreservation-bank-in-the-netherlands
#11
Marjolein R Bakker, Joyce Maas, Marrie H Bekker, Annelien L Bredenoord, Bart C Fauser, Annelies M Bos
Worldwide, oocyte donors donate voluntarily or receive varying amounts of money for donation. This raises ethical questions regarding the appropriateness of financial compensation, and the possibility of undue inducement and exploitation of oocyte donors. Are these donors capable of making an independent, well-considered decision? Regarding this matter, it is important to examine aspects such as autonomy-connectedness and self-esteem. In this cross-sectional study, demographic characteristics and donation motivations were assessed in 92 women who attended the University Medical Center (UMC) Utrecht as potential oocyte donors between June 2012 and July 2016...
May 17, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28558214/substitution-effects-on-the-photoinduced-charge-transfer-properties-of-novel-perylene-3-4-9-10-tetracarboxylic-acid-derivatives
#12
Damla Inan, Rajeev K Dubey, Nick Westerveld, Jorrit Bleeker, Wolter F Jager, Ferdinand C Grozema
We report here the synthesis and photophysical study of a series of electron donor-acceptor molecules, in which electron-donating 4-methoxyphenoxy groups are attached to the 1,7-bay positions of four different perylene tetracarboxylic acid derivatives, namely, perylene tetraesters 1, perylene monoimide diesters 2, perylene bisimides 3, and perylene monobenzimidazole monoimides 4. These perylene derivatives are used because of their increasing order of electron-accepting capability upon moving from 1 to 4. Two additional donor-acceptor molecules are synthesized by linking electron-donating 4-methoxyphenyl groups to the imide position of perylene monoimide diester 2 and perylene bisimide 3...
June 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28557101/the-association-between-interval-from-acceptance-to-first-time-donation-missed-first-appointment-and-future-donation-behaviour
#13
S A Mousavi, B Hermundstad, T R Knutsen, A H Llohn
BACKGROUND AND OBJECTIVES: We examined the association of the interval between the date an individual is accepted for blood donation and the date of first donation (IFD-interval, index-to-first-time donation interval) and missed first appointment with future donation behaviour among new donors. These two variables have not been analysed in previous studies of donation behaviour among new donors. METHODS: Categories were generated for age (18-29 vs 30-65 years), missed-appointment status (no-show vs same-day cancellation) and the IFD-interval [short (≤median time) vs long (>median time)]...
May 29, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28550979/status-of-blood-transfusion-in-world-health-organization-eastern-mediterranean-region-who-emr-successes-and-challenges
#14
REVIEW
Arezoo Darbandi, Pargol Mashati, Amir Yami, Arshia Gharehbaghian, Mehdi Tabrizi Namini, Ahmad Gharehbaghian
BACKGROUND: Blood products are used for patient treatment and survival in the cases of major surgery, hematological disorders or cancer therapy. Presently the main blood components are not yet replaceable by artificial products and all activities related to blood transfusion is highly dependent on the healthcare development of each country. The World Health Organization Eastern Mediterranean Region (WHO-EMR) comprises of 21 member states with variable socio-economic status effective on blood transfusion activities...
May 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28549399/a-systematic-review-investigating-psychosocial-aspects-of-egg-sharing-in-the-united-kingdom-and-their-potential-effects-on-egg-donation-numbers
#15
Timothy Bracewell-Milnes, Srdjan Saso, Hossam Abdalla, Meen-Yau Thum
This review aims to provide an up-to-date knowledge of the psychosocial aspects of egg donation from the perspectives of the egg share donor and their recipient. It explores the motives, experiences and attitudes of egg sharers and their views towards donor anonymity and disclosure. Conclusions are made on how these findings can guide clinical practice and improve egg sharing numbers. A systematic search of peer-reviewed journals of four computerized databases was undertaken. Eleven studies were included in the review...
May 26, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28547759/blood-donors-attitudes-towards-voluntary-non-remunerated-donation-in-trinidad-and-tobago
#16
K S Charles, A Poon King, A Ramai, K Rajnath, D Ramkissoon, S Ramkissoon, C Ramlal, K Ramnarine, K Rampersad, G Legall, S Pooransingh, A D Chantry
OBJECTIVES: To assess the attitude towards voluntary non-remunerated blood donation among blood donors in Trinidad and Tobago (TRT). BACKGROUND: Blood donors in TRT are either family replacement (F/R, 87%) or remunerated (13%). There is chronic blood shortage and high seroreactivity for transfusion-transmissible infections (TTI) in donors. Converting existing to voluntary non-remunerated donors (VNRD) reduces the need to recruit news donors in achieving 100% VNRD...
May 26, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28542841/blood-donors-perceptions-motivators-and-deterrents-in-sub-saharan-africa-a-scoping-review-of-evidence
#17
REVIEW
Lucy Asamoah-Akuoko, Oliver W Hassall, Imelda Bates, Henrik Ullum
Achieving an adequate blood supply in Sub-Saharan Africa (SSA) through donor mobilization and retention is crucial. Factors that motivate or deter blood donors vary according to beliefs and social norms. Understanding the factors that influence blood donation behaviour in SSA is vital to developing effective strategies to address blood donor motivation and retention. This review of 35 studies from 16 SSA countries collates available evidence concerning the perceptions, motivators and deterrents that influence blood donors in SSA...
June 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28527046/on-harm-thresholds-and-living-organ-donation-must-the-living-donor-benefit-on-balance-from-his-donation
#18
Nicola Jane Williams
For the majority of scholars concerned with the ethics of living organ donation, inflicting moderate harms on competent volunteers in order to save the lives or increase the life chances of others is held to be justifiable provided certain conditions are met. These conditions tend to include one, or more commonly, some combination of the following: (1) The living donor provides valid consent to donation. (2) Living donation produces an overall positive balance of harm-benefit for donors and recipients which cannot be obtained in a less harmful manner...
May 19, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28515024/knowledge-attitude-and-practice-towards-blood-donation-among-health-care-providers-in-hospitals-at-bahir-dar-city-ethiopia
#19
Bayeh Abera, Beyan Mohammed, Wendmagegn Betela, Reshid Yimam, Adam Oljira, Merhab Ahmed, Wubet Tsega, Wondemagegn Mulu, Endalew Yizengaw
Like other sub-Saharan Africa, in Ethiopia there is a shortage of adequate and safe blood supplies. Health care providers are potential resource and promoter of voluntary blood donation. This study was conducted to determine the knowledge, attitude and practice towards blood donation among health care providers in Bahir Dar City, Ethiopia. Paper based questionnaire was distributed to 276 health care providers from May 01 to June 30, 2016. Overall, 42.8% had donated blood at least once. Of these, males accounted for 60%...
April 26, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28510355/the-national-landscape-of-living-kidney-donor-follow-up-in-the-united-states
#20
Macey L Henderson, Alvin G Thomas, Ashton Shaffer, Allan B Massie, Xun Luo, Courtenay M Holscher, Tanjala S Purnell, Krista Lentine, Dorry L Segev
In 2013, OPTN/UNOS mandated that transplant centers collect data on living kidney donors (LKDs) at 6-months, 1-year, and 2-years post-donation, with policy-defined thresholds for the proportion of complete living donor follow-up (LDF) data submitted in a timely manner (60 days before or after the expected visit date). While mandated, it was unclear how centers across the country would perform in meeting thresholds, given potential donor and center-level challenges of LDF. To better understand the impact of this policy, we studied SRTR data for 31,615 LKDs between 1/2010-6/2015, comparing proportions of complete and timely LDF form submissions pre- and post-policy implementation...
May 16, 2017: American Journal of Transplantation
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