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https://www.readbyqxmd.com/read/29164313/genome-wide-analysis-of-a-recently-active-retrotransposon-au-sine-in-wheat-content-distribution-within-subgenomes-and-chromosomes-and-gene-associations
#1
Danielle Keidar, Chen Doron, Khalil Kashkush
Here, we show that Au SINE elements have strong associations with protein-coding genes in wheat. Most importantly Au SINE insertion within introns causes allelic variation and might induce intron retention. The impact of transposable elements (TEs) on genome structure and function is intensively studied in eukaryotes, especially in plants where TEs can reach up to 90% of the genome in some cases, such as in wheat. Here, we have performed a genome-wide in-silico analysis using the updated publicly available genome draft of bread wheat (T...
November 21, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/29154977/polymer-nitric-oxide-donors-potentiate-the-treatment-of-experimental-solid-tumours-by-increasing-drug-accumulation-in-the-tumour-tissue
#2
M Studenovsky, L Sivak, O Sedlacek, R Konefal, V Horkova, T Etrych, M Kovar, B Rihova, M Sirova
The delivery of nitric oxide (NO) specifically to solid tumours was explored in this study as a strategy to augment the passive accumulation of nanomedicines in tumours induced by the Enhanced Permeability and Retention (EPR) effect. An increase in accumulation was achieved by the binding of the chemical precursor of NO, based on an organic nitrate, to a water-soluble synthetic polymer drug carrier. Four structurally different N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer NO donors were synthesized...
November 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29149965/comparision-of-ureteral-stent-colonization-between-deceased-and-live-donor-renal-transplant-recipients
#3
M Sarier, D Seyman, S Tekin, I Duman, B Uygun, M Demir, E Kukul, A H Yavuz
BACKGROUND: The use of a ureteral stent can cause a urinary tract infection (UTI), although it reduces urologic complications. UTIs are associated with a higher rate of ureteral stent colonization (USC). The aim of this study was to compare USC in living and deceased donor renal transplant recipients. MATERIAL AND METHODS: We conducted a prospective study of 48 patients who underwent renal transplantation between January and December 2016. The stents were removed aseptically, the inner surface of proximal and distal ends of stents were irrigated with liquid culture medium, and then they were vortexed for bacteriological investigation...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29148749/glycosyl-cross-coupling-of-anomeric-nucleophiles-scope-mechanism-and-applications-in-the-synthesis-of-aryl-c-glycosides
#4
Feng Zhu, Jacob Rodriguez, Tianyi Yang, Ilia Kevlishvili, Eric Miller, Duk Yi, Sloane O'Neill, Michael Rourke, Peng Liu, Maciej A Walczak
Stereoselective manipulations at the C1 anomeric position of saccharides are one of the central goals of preparative carbohydrate chemistry. Historically, the majority of reactions forming a bond with anomeric carbon has focused on reactions of nucleophiles with saccharide donors equipped with a leaving group. Here, we describe a novel approach to stereoselective synthesis of C-aryl glycosides capitalizing on the highly stereospecific reaction of anomeric nucleophiles. First, methods for the preparation of anomeric stannanes have been developed and optimized to afford both anomers of common saccharides in high anomeric selectivities...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29141214/partitioning-of-one-carbon-units-in-folate-and-methionine-metabolism-is-essential-for-neural-tube-closure
#5
Kit-Yi Leung, Yun Jin Pai, Qiuying Chen, Chloe Santos, Enrica Calvani, Sonia Sudiwala, Dawn Savery, Markus Ralser, Steven S Gross, Andrew J Copp, Nicholas D E Greene
Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and, therefore, represents a key nexus in partitioning one-carbon units between FOCM functional outputs. Methionine cycle inhibitors prevent neural tube closure in mouse embryos. Similarly, the inability to use glycine as a one-carbon donor to the folate cycle causes NTDs in glycine decarboxylase (Gldc)-deficient embryos...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29131594/primary-amine-clustered-dna-aptamer-for-dna-protein-conjugation-catalyzed-by-microbial-transglutaminase
#6
Mari Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya
DNA-protein conjugates are promising biomolecules for use in areas ranging from therapeutics to analysis because of the dual functionalities of DNA and protein. Conjugation requires site-specific and efficient covalent bond formation without impairing the activity of both biomolecules. Herein, we have focused on the use of a microbial transglutaminase (MTG) that catalyzes the cross-linking reaction between a glutamine residue and a primary amine. In a model bioconjugation, a highly MTG-reactive Gln (Q)-donor peptide (FYPL<u>Q</u>MRG, FQ) was fused to enhanced green fluorescent protein (FQ-EGFP) and a primary amine-clustered DNA aptamer was enzymatically synthesized as a novel acyl-acceptor substrate of MTG, whose combination leads to efficient and convenient preparation of DNA-protein conjugates with high purity...
November 13, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29127860/human-embryonic-stem-cell-derived-cardiovascular-progenitor-cells-efficiently-colonize-in-bfgf-tethered-natural-matrix-to-construct-contracting-humanized-rat-hearts
#7
Sarah Rajabi, Sara Pahlavan, Mohammad Kazemi Ashtiani, Hassan Ansari, Saeed Abbasalizadeh, Forough Azam Sayahpour, Fahimeh Varzideh, Sawa Kostin, Nasser Aghdami, Thomas Braun, Hossein Baharvand
Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to overcome organ donor shortage threatening millions of patients awaiting for heart transplantation. Here, we developed a novel strategy for generation of heart constructs by repopulating engineered decellularized rat hearts using hESCs-derived CPCs. Careful expansion of CPCs in a scalable stirred-suspension bioreactor combined with step-wise seeding (60 million cells in 3 steps of 20 million per 1...
November 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/29126567/the-role-of-different-functional-groups-in-a-novel-adsorption-complexation-reduction-multi-step-kinetic-model-for-hexavalent-chromium-retention-by-undissolved-humic-acid
#8
Jia Zhang, Huilin Yin, Linpeng Chen, Fei Liu, Honghan Chen
Undissolved humic acid (HA) has a great retention effect on the migration of hexavalent chromium [Cr(VI)] in soil, and HA functional groups play a predominant role in this process. However, the coupled mode between Cr(VI) retention and HA functional groups reaction is still unclear. In this study, it was found that a fair amount of Cr on HA existed in the forms of ion exchangeable and binding Cr(VI) during the reaction resulting from the ion exchange adsorption and complexation of Cr(VI). According to the results of two-dimensional correlation spectroscopic analysis (2DCOS), HA functional groups participated in the reaction with Cr(VI) in the order of carboxyl ≈ chelated carboxyl > phenol > polysaccharide > methyl, and all the functional groups were more likely to be located at aromatic domains...
November 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29117575/self-assembling-peptide-hydrogel-enables-instant-epicardial-coating-of-the-heart-with-mesenchymal-stromal-cells-for-the-treatment-of-heart-failure
#9
Yuki Ichihara, Masahiro Kaneko, Kenichi Yamahara, Marinos Koulouroudias, Nobuhiko Sato, Rakesh Uppal, Kenji Yamazaki, Satoshi Saito, Ken Suzuki
Transplantation of mesenchymal stromal cells (MSCs) is an emerging therapy for the treatment of heart failure. However, the delivery method of MSC is currently suboptimal. The use of self-assembling peptide hydrogels, including PuraMatrix(®) (PM; 3-D Matrix, Ltd), has been reported for clinical hemostasis and in research models. This study demonstrates the feasibility and efficacy of an advanced approach for MSC-therapy, that is coating of the epicardium with the instantly-produced PM hydrogel incorporating MSCs (epicardial PM-MSC therapy)...
October 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/29106732/a-systematic-review-of-incentives-in-blood-donation
#10
Kathleen Chell, Tanya E Davison, Barbara Masser, Kyle Jensen
BACKGROUND: Incentives are often used to enhance the effectiveness of recruitment and retention campaigns targeting blood donors. However, the degree to which incentives succeed in attracting and facilitating repeat donation is unclear. A systematic literature review, following PRISMA guidelines, investigated the existing empirical evidence regarding the use of monetary and nonmonetary incentives within blood donation. STUDY DESIGN AND METHODS: A comprehensive search of relevant databases identified a total of 71 papers for inclusion in the review for defining and operationalizing incentives (Objective 1), of which nine papers empirically investigated attitudes toward incentives (Objective 2), 31 papers investigated the impact on blood donation behavior (Objective 3), and eight papers investigated the impact on blood safety (Objective 4)...
November 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29101192/fecal-microbiota-transplant-from-highly-feed-efficient-donors-shows-little-effects-on-age-related-changes-in-feed-efficiency-associated-fecal-microbiota-in-chickens
#11
Sina-Catherine Siegerstetter, Renée M Petri, Elizabeth Magowan, Peadar G Lawlor, Qendrim Zebeli, Niamh E O'Connell, Barbara U Metzler-Zebeli
Chickens of good and poor feed efficiency (FE) have been shown to differ in their intestinal microbiota composition. This study investigated differences in the fecal bacterial community of good and poor feed efficient chickens at 16 and 29 days post-hatch (dph) and evaluated whether a fecal microbiota transplant (FMT) from feed efficient donors early in life can affect the fecal microbiota in chickens at 16 and 29 dph, chicken's FE and nutrient retention at four weeks of age. One-hundred-ten chickens were inoculated with a FMT or a control transplant (CT) on 1, 6 and 9 dph and ranked according to residual feed intake (RFI; metric for FE) on 30 dph...
November 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29069333/plant-mediated-horizontal-transmission-of-rickettsia-endosymbiont-between-different-whitefly-species
#12
Yi-Han Li, Muhammad Z Ahmed, Shao-Jian Li, Ning Lv, Pei-Qiong Shi, Xiao-Sheng Chen, Bao-Li Qiu
A growing number of studies have revealed the presence of closely related endosymbionts in phylogenetically distant arthropods, underlying the horizontal transmission of these bacteria. Here we investigated the interspecific horizontal transmission of Rickettsia between two globally invasive whitefly species, Bemisia tabaci MEAM1 and B. tabaci MED, via cotton plants. We found both scattered and confined distribution patterns of Rickettsia in these whiteflies. After entering cotton leaves, Rickettsia was restricted to the leaf phloem vessels and could be taken up by both species of the Rickettsia -free whitefly adults, but only the scattered pattern was observed in the recipient whiteflies...
October 23, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29051852/single-near-infrared-emissive-polymer-nanoparticles-as-versatile-phototheranostics
#13
Liang Guo, Guangle Niu, Xiuli Zheng, Jiechao Ge, Weimin Liu, Qingyan Jia, Panpan Zhang, Hongyan Zhang, Pengfei Wang
Attaining consistently high performance of diagnostic and therapeutic functions in one single nanoplatform is of great significance for nanomedicine. This study demonstrates the use of donor-acceptor (D-A) structured polymer (TBT) to develop a smart "all-five-in-one" theranostic that conveniently integrates fluorescence/photoacoustic/thermal imaging and photodynamic/photothermal therapy into single nanoparticle. The prepared nanoparticles (TBTPNPs) exhibit near-infrared emission, high water solubility, excellent light resistance, good pH stability, and negligible toxicity...
October 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29051810/controlled-dexamethasone-delivery-via-double-walled-microspheres-to-enhance-long-term-adipose-tissue-retention
#14
Arta Kelmendi-Doko, J Peter Rubin, Katarina Klett, Christopher Mahoney, Sheri Wang, Kacey G Marra
Current materials used for adipose tissue reconstruction have critical shortcomings such as suboptimal volume retention, donor-site morbidity, and poor biocompatibility. The aim of this study was to examine a controlled delivery system of dexamethasone to generate stable adipose tissue when mixed with disaggregated human fat in an athymic mouse model for 6 months. The hypothesis that the continued release of dexamethasone from polymeric microspheres would enhance both adipogenesis and angiogenesis more significantly when compared to the single-walled microsphere model, resulting in long-term adipose volume retention, was tested...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29039791/synthesis-of-chiral-tfa-protected-%C3%AE-amino-aryl-ketone-derivatives-with-friedel-crafts-acylation-of-%C3%AE-amino-acid-n-hydroxysuccinimide-ester
#15
Zetryana Puteri Tachrim, Kazuhiro Oida, Haruka Ikemoto, Fumina Ohashi, Natsumi Kurokawa, Kento Hayashi, Mami Shikanai, Yasuko Sakihama, Yasuyuki Hashidoko, Makoto Hashimoto
Chiral N-protected α-amino aryl-ketones are one of the useful precursors used in the synthesis of various biologically active compounds and can be constructed via Friedel-Crafts acylation of N-protected α-amino acids. One of the drawbacks of this reaction is the utilization of toxic, corrosive and moisture-sensitive acylating reagents. In peptide construction via amide bond formation, N-hydroxysuccinimide ester (OSu), which has high storage stability, can react rapidly with amino components and produces fewer side reactions, including racemization...
October 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29036025/the-fate-of-the-adipose-derived-stromal-cells-during-angiogenesis-and-adipogenesis-after-cell-assisted-lipotransfer
#16
Ki Yong Hong, Sangjun Yim, Hyun Jung Kim, Ung Sik Jin, SooA Lim, SuRak Eo, Hak Chang, Kyung Won Minn
BACKGROUND: Cell-assisted lipotransfer (CAL) is a process in which fat grafting is supplemented with autologous adipose-derived stromal cells (ASCs). Since the efficacy of the technique was demonstrated, studies have focused on the mechanism by which CAL enhances the rate of graft survival. However, the microenvironmental changes in donor and recipient tissue associated with CAL remain unclear. METHODS: We introduced an animal model of CAL using two different transgenic reporter mice...
October 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28985407/ustur-whole-body-case-0212-17-year-follow-up-of-plutonium-contaminated-wound
#17
Maia Avtandilashvili, Sara Dumit, Sergei Y Tolmachev
The National Council of Radiation Protection and Measurements' (NCRP) wound model was applied to the bioassay data from a United States Transuranium and Uranium Registries' whole-body tissue donor, Case 0212. This individual was exposed to plutonium nitrate as a result of an occupational wound injury and he underwent extensive chelation treatment with Ca-DTPA. All major soft tissues and bones were collected post-mortem and radiochemically analyzed for 238Pu, 239,240Pu and 241Am. The 239,240Pu activity in the total body was estimated to be 232...
July 7, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28979255/ph-control-enables-simultaneous-enhancement-of-nitrogen-retention-and-n2o-reduction-in-shewanella-loihica-strain-pv-4
#18
Hayeon Kim, Doyoung Park, Sukhwan Yoon
pH has been recognized as one of the key environmental parameters with significant impacts on the nitrogen cycle in the environment. In this study, the effects of pH on NO3(-)/NO2(-) fate and N2O emission were examined with Shewanella loihica strain PV-4, an organism with complete denitrification and respiratory ammonification pathways. Strain PV-4 was incubated at varying pH with lactate as the electron donor and NO3(-)/NO2(-) and N2O as the electron acceptors. When incubated with NO3(-) and N2O at pH 6.0, transient accumulation of N2O was observed and no significant NH4(+) production was observed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28968094/quantifying-technetium-and-strontium-bioremediation-potential-in-flowing-sediment-columns
#19
Clare L Thorpe, Gareth T W Law, Jonathan R Lloyd, Heather A Williams, Nick Atherton, Katherine Morris
The high-yield fission products (99)Tc and (90)Sr are found as problematic radioactive contaminants in groundwater at nuclear sites. Treatment options for radioactively contaminated land include bioreduction approaches, and this paper explores (99m)Tc and (90)Sr behavior and stability under a range of biogeochemical conditions stimulated by electron donor addition methods. Dynamic column experiments with sediment from the Sellafield nuclear facility, completed at site relevant flow conditions, demonstrated that Fe(III)-reducing conditions had developed by 60 days...
November 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28960760/structural-snapshots-of-%C3%AE-1-3-galactosyltransferase-with-native-substrates-insight-into-the-catalytic-mechanism-of-retaining-glycosyltransferases
#20
David Albesa-Jové, M Ángela Sainz-Polo, Alberto Marina, Marcelo E Guerin
Glycosyltransferases (GTs) are a key family of enzymes that catalyze the synthesis of glycosidic bonds in all living organisms. The reaction involves the transfer of a glycosyl moiety and can proceed with retention or inversion of the anomeric configuration. To date, the catalytic mechanism of retaining GTs is a topic of great controversy, particularly for those enzymes containing a putative nucleophilic residue in the active site, for which the occurrence of a double-displacement mechanism has been suggested...
September 28, 2017: Angewandte Chemie
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