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https://www.readbyqxmd.com/read/29750674/evaluating-plutonium-intake-and-radiation-dose-following-extensive-chelation-treatment
#1
Sara Dumit, Maia Avtandilashvili, Sergei Y Tolmachev
A voluntary partial-body donor (U.S. Transuranium and Uranium Registries Case 0785) was accidentally exposed to Pu via inhalation and wounds. This individual underwent medical treatment including wound excision and extensive chelation treatment with calcium ethylenediaminetetraacetic acid and calcium diethylenetriaminepentaacetic acid. Approximately 2.2 kBq of Pu was measured in the wound site 44 y after the accident. Major soft tissues and selected bones were collected at autopsy and radiochemically analyzed for Pu, Pu, and Am...
May 4, 2018: Health Physics
https://www.readbyqxmd.com/read/29750175/towards-90-90-90-target-factors-influencing-availability-access-and-utilization-of-hiv-services-a-qualitative-study-in-19-ugandan-districts
#2
Francis Bajunirwe, Flora Tumwebaze, Denis Akakimpa, Cissy Kityo, Peter Mugyenyi, George Abongomera
Background: UNAIDS has set a new target 90-90-90 by 2020. To achieve this target, current programs need to address challenges that limit access, availability, and utilization of HIV testing and treatment services. Therefore, the aim of this study was to identify the barriers that influence access, availability, and utilization of HIV services in rural Uganda within the setting of a large donor funded program. Methods: We conducted key informant interviews with stakeholders at the district level, staff of existing HIV/AIDS projects, and health facilities in 19 districts...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29740456/newly-identified-wild-rice-accessions-conferring-high-salt-tolerance-might-use-a-tissue-tolerance-mechanism-in-leaf
#3
Manas R Prusty, Sung-Ryul Kim, Ricky Vinarao, Frederickson Entila, James Egdane, Maria G Q Diaz, Kshirod K Jena
Cultivated rice ( Oryza sativa L.) is very sensitive to salt stress. So far a few rice landraces have been identified as a source of salt tolerance and utilized in rice improvement. These tolerant lines primarily use Na+ exclusion mechanism in root which removes Na+ from the xylem stream by membrane Na+ and K+ transporters, and resulted in low Na+ accumulation in shoot. Identification of a new donor source conferring high salt tolerance is imperative. Wild relatives of rice having wide genetic diversity are regarded as a potential source for crop improvement...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29720200/splice-site-mutation-causing-partial-retention-of-intron-in-the-flcn-gene-in-birt-hogg-dub%C3%A3-syndrome-a-case-report
#4
Mitsuko Furuya, Hironori Kobayashi, Masaya Baba, Takaaki Ito, Reiko Tanaka, Yukio Nakatani
BACKGROUND: Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant disorder caused by germline mutations in the folliculin gene (FLCN). Nearly 150 pathogenic mutations have been identified in FLCN. The most frequent pattern is a frameshift mutation within a coding exon. In addition, splice-site mutations have been reported, and previous studies have confirmed exon skipping in several cases. However, it is poorly understood whether there are any splice-site mutations that cause translation of intron regions in FLCN...
May 2, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29719692/photosensitizer-synergistic-effects-d-a-d-structured-organic-molecule-with-enhanced-fluorescence-and-singlet-oxygen-quantum-yield-for-photodynamic-therapy
#5
Jianhua Zou, Zhihui Yin, Peng Wang, Dapeng Chen, Jinjun Shao, Qi Zhang, Liguo Sun, Wei Huang, Xiaochen Dong
The development of photosensitizers with high fluorescence intensity and singlet oxygen (1 O2 ) quantum yields (QYs) is of great importance for cancer diagnosis and photodynamic therapy (PDT). Diketopyrrolopyrrole (DPP) and boron dipyrromethene (BODIPY) are two kinds of building block with great potential for PDT. Herein, a novel donor-acceptor-donor (D-A-D) structured organic photosensitizer DPPBDPI with a benzene ring as a π bridge linking DPP and BODIPY has been designed and synthesized. The results indicate that the combination of DPP with BODIPY can simultaneously increase the fluorescence QY (5...
February 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29713582/association-analysis-of-drought-tolerance-in-cut-chrysanthemum-chrysanthemum-morifolium-ramat-at-seedling-stage
#6
Pirui Li, Jiangshuo Su, Zhiyong Guan, Weimin Fang, Fadi Chen, Fei Zhang
Understanding the genetic architecture is a prerequisite for crop improvement. The current research aimed to characterize the extent of genetic variation of drought tolerance harbored in a global collection of 159 chrysanthemum cultivars over 2 years. An average subordinate function value (ASFV), integrating the wilting index, the fresh weight retention rate, and the survival rate after re-watering under two drought-stressed trials, was used to quantify the level of drought tolerance. The performance of ASFV was generally correlated between the 2 years; and a high magnitude (0...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29710589/effects-of-influent-nitrogen-loads-on-nitrogen-and-cod-removal-in-horizontal-subsurface-flow-constructed-wetlands-during-different-growth-periods-of-phragmites-australis
#7
Xuelan Liu, Yan Zhang, Xinhua Li, Chunyan Fu, Tianhong Shi, Peipei Yan
Horizontal subsurface constructed wetlands (HSSF-CWs) planted with Phragmites australis were established to examine the effect of influent nitrogen loads on the removal efficiencies of nitrogen and chemical oxygen demand (COD) during different plant growth periods of plants. Under low influent nitrogen loads, most of the dissolved oxygen was consumed during the oxidation of organic matter in the wetland systems, and a dissimilatory nitrate reduction to ammonium (DNRA) may have occurred in HSSF-CWs when excessive amounts of organic matter were present, which limited the nitrification of ammonium nitrogen (NH4 -N) and hindered the NH4 -N removal...
April 24, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29708754/quantitative-attachment-of-bimetal-combinations-of-transition-metal-ions-to-the-surface-of-tio-2-nanorods
#8
Choumini Balasanthiran, Stephanie Jensen, Charles S Spanjers, Shelton J P Varapragasam, Robert M Rioux, Dmitri Kilin, James D Hoefelmeyer
We report the sequential, quantitative loading of transition-metal ions (Cr3+ , Mn2+ , Fe2+ , Co2+ , Ni2+ , and Cu2+ ) onto the surface of rod-shaped anatase TiO2 nanocrystals in bimetallic combinations (6 C2 = 15) to form M,M'-TiO2 nanocrystals. The materials were characterized with transmission electron microscopy (TEM), powder X-ray diffraction (XRD), elemental analysis, X-ray photoelectron spectroscopy (XPS), and UV-visible spectroscopy. TEM and XRD data indicate that the sequential adsorption of metal ions occurs with the retention of the phase and morphology of the nanocrystal...
April 30, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29676558/utilizing-intramolecular-photoinduced-electron-transfer-to-enhance-photothermal-tumor-treatment-of-aza-bodipy-based-nir-nanoparticles
#9
Yunjian Xu, Teng Feng, Tianshe Yang, Huanjie Wei, Huiran Yang, Guo Li, Menglong Zhao, Shujuan Liu, Wei Huang, Qiang Zhao
Photothermal therapy (PTT) as a kind of noninvasive tumor treatment has attracted increasing research interest. However, the efficiency of existing PTT agents in the near-infrared (NIR) region is the major problem that has hindered further development of PTT. Herein, we present an effective strategy to construct the efficient photothermal agent by utilizing an intramolecular photoinduced electron transfer (PeT) mechanism, which is able to dramatically improve photothermal conversion efficiency in NIR region...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29673061/decellularization-and-characterization-of-a-whole-intervertebral-disc-xenograft-scaffold
#10
Austin Hensley, Jess Rames, Victor Casler, Christopher Rood, Joshua Walters, Christopher Fernandez, Sanjitpal Gill, Jeremy Mercuri
Intervertebral disc (IVD) degeneration is a multi-factor process that results in the physical destruction of the nucleus pulposus (NP) and annulus fibrosus (AF). This compromises IVD function and causes significant disability and economic burden. Strategies to replace the entire composite structure of the IVD are limited and most approaches do not recapitulate the heterogenous biochemical composition, micro-architecture or mechanical properties of the native tissue. Our central hypothesis was that donor IVDs which resemble the size and biochemistry of human lumbar IVDs could be successfully decellularized while retaining the tissue's structure and function with the long-term goal of creating a composite scaffold for tissue engineering the human IVD...
April 19, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29651303/reproducible-high-yielding-biological-caproate-production-from-food-waste-using-a-single-phase-anaerobic-reactor-system
#11
Corine Orline Nzeteu, Anna Christine Trego, Florence Abram, Vincent O'Flaherty
Background: Nowadays, the vast majority of chemicals are either synthesised from fossil fuels or are extracted from agricultural commodities. However, these production approaches are not environmentally and economically sustainable, as they result in the emission of greenhouse gases and they may also compete with food production. Because of the global agreement to reduce greenhouse gas emissions, there is an urgent interest in developing alternative sustainable sources of chemicals. In recent years, organic waste streams have been investigated as attractive and sustainable feedstock alternatives...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29625577/gene-therapy-in-rare-diseases-the-benefits-and-challenges-of-developing-a-patient-centric-registry-for-strimvelis-in-ada-scid
#12
Heide Stirnadel-Farrant, Mahesh Kudari, Nadia Garman, Jessica Imrie, Bikramjit Chopra, Stefania Giannelli, Michela Gabaldo, Ambra Corti, Stefano Zancan, Alessandro Aiuti, Maria Pia Cicalese, Rohit Batta, Jonathan Appleby, Mario Davinelli, Pauline Ng
BACKGROUND: Strimvelis (autologous CD34+ cells transduced to express adenosine deaminase [ADA]) is the first ex vivo stem cell gene therapy approved by the European Medicines Agency (EMA), indicated as a single treatment for patients with ADA-severe combined immunodeficiency (ADA-SCID) who lack a suitable matched related bone marrow donor. Existing primary immunodeficiency registries are tailored to transplantation outcomes and do not capture the breadth of safety and efficacy endpoints required by the EMA for the long-term monitoring of gene therapies...
April 6, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29623643/reduction-mechanism-of-hexavalent-chromium-by-functional-groups-of-undissolved-humic-acid-and-humin-fractions-of-typical-black-soil-from-northeast-china
#13
Jia Zhang, Huilin Yin, Hui Wang, Lin Xu, Barnie Samuel, Fei Liu, Honghan Chen
Soil organic matters (SOM) have a great retention effect on Cr(VI) migration in subsurface environment, which act as the main electron donors for Cr(VI) reduction; however, Cr(VI) reduction mechanism by different SOM fractions is still unclear, such as undissolved humic acid (HA) and humin (HM). In this study, HA and HM fractions extracted from typical black soil from Northeast China were used to investigate the reaction mechanism between humus functional groups and Cr(VI). According to the results, phenol and hydroxyl were determined as the main electron donors for Cr(VI) reduction by HA and HM instead of carboxyl and carbonyl, which were more likely involved in Cr complexation...
April 5, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29617055/-development-of-a-large-volume-human-derived-adipose-acellular-allogenic-flap-aafs-by-perfusion-decellularization
#14
Giorgio Giatsidis, Jacques P Guyette, Harald C Ott, Dennis P Orgill
In reconstructive surgery, transfer of patients' tissue (autologous flaps) is routinely used to repair large soft tissue defects caused by surgery, trauma, chronic diseases, or malformations; unfortunately, this strategy is not always possible and often creates a secondary defect in the donor site of the tissue. Tissue-engineered synthetic flaps are currently unable to repair clinically-relevant, large-volume defects; allogenic flaps from cadaveric donors could provide a ready-to-use biological alternative if treated with methods to avoid the immune-rejection of the donor's cells...
April 4, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29615807/an-intronic-mutation-in-chd7-creates-a-cryptic-splice-site-causing-aberrant-splicing-in-a-mouse-model-of-charge-syndrome
#15
Jacqueline M Ogier, Benedicta D Arhatari, Marina R Carpinelli, Bradley K McColl, Michael A Wilson, Rachel A Burt
Alternate splicing is a critical regulator of gene expression in eukaryotes, however genetic mutations can cause erroneous splicing and disease. Most recorded splicing disorders are caused by mutations of splice donor/acceptor sites, however intronic mutations can affect splicing. Clinical exome analyses largely ignore intronic sequence, limiting the detection of mutations to within coding regions. We describe 'Trooper', a novel mouse model of CHARGE syndrome harbouring a pathogenic point mutation in Chd7. The mutation is 18 nucleotides upstream of exon 10 and creates a cryptic acceptor site, causing exon skipping and partial intron retention...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608324/the-devil-is-in-the-details-retention-of-recipient-group-a-type-5-years-after-a-successful-allogeneic-bone-marrow-transplant-from-a-group-o-donor
#16
Laura L W Cooling, Michelle Herrst, Sherri L Hugan
ABO-incompatible (ABOi) hematopoietic stem cell transplants (HSCTs) can present challenges in the blood bank. During transplantation, patients receive components that are ABO-compatible with both the donor graft and recipient; this practice can strain group O red blood cell (RBC) inventories.1 In addition, there are risks for acute hemolysis at the time of infusion and in the early post-transplant period.1,2 In ABO major-incompatible bone marrow HSCTs, which contain significant quantities of donor RBCs that are ABOi with recipient plasma, it is common to perform a RBC depletion of the bone marrow in an effort to minimize hemolysis at the time of infusion...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29574766/in-vitro-evaluation-of-di-2-ethylhexyl-terephthalate-plasticized-polyvinyl-chloride-blood-bags-for-red-blood-cell-storage-in-as-1-and-paggsm-additive-solutions
#17
Sharon Graminske, Kathleen Puca, Anna Schmidt, Scott Brooks, Amanda Boerner, Sybil Heldke, Monika de Arruda Indig, Mark Brucks, David Kossor
BACKGROUND: Di(2-ethylhexyl)phthalate (DEHP) makes polyvinyl chloride flexible for use in blood bags and stabilizes the red blood cell (RBC) membrane preventing excessive hemolysis. DEHP migrates into the blood product and rodent studies have suggested that DEHP exposure may be associated with adverse health effects albeit at high dosages. Although structurally and functionally similar to DEHP, di(2-ethylhexyl)terephthalate (DEHT; or Eastman 168 SG [Eastman Chemical Company]) is metabolically distinct with a comprehensive and benign toxicology profile...
May 2018: Transfusion
https://www.readbyqxmd.com/read/29565633/effect-of-the-piastra-benchtop-flash-heating-pasteurizer-on-immune-factors-of-donor-human-milk
#18
Brodie Daniels, Penny Reimers, Tracy King, Stefan Schmidt, Anna Coutsoudis
INTRODUCTION: PiAstra is a simulated flash-heat (FH) pasteurization temperature monitoring system designed using Raspberry Pi technology for the pasteurization of human milk. This study analyzed the effect of the PiAstra FH method on human milk immune components (immunoglobulin A [IgA] and lactoferrin activity). METHODS: Donor milk samples (N = 45) were obtained from a human milk bank, and pasteurized. Concentrations of IgA and lactoferrin activity were compared to their unpasteurized controls using the Student's t test...
March 22, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29517525/where-hospital-boards-often-fail-auditing-leadership-performance
#19
Susan Y Friedman, Mitchell T Rabkin
Hospital boards address quality of care and patient safety as well as financial performance through long-accepted practices. By contrast, a hospital's administrative operations and institutional culture are not usually subject to such detailed scrutiny. Yet, despite a healthy bottom line and patient commendations, hospital personnel can be underperforming, burdened with poor morale, and suffering from less than optimal leadership, unwarranted inefficiency, and ethically questionable management practices. The resulting employee dissatisfaction or disengagement can affect productivity, quality, turnover, innovation, patient and donor attraction and retention, public image, etc...
March 6, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29512198/design-and-development-of-biomimetic-nanovesicles-using-a-microfluidic-approach
#20
Roberto Molinaro, Michael Evangelopoulos, Jessica R Hoffman, Claudia Corbo, Francesca Taraballi, Jonathan O Martinez, Kelly A Hartman, Donato Cosco, Giosue' Costa, Isabella Romeo, Michael Sherman, Donatella Paolino, Stefano Alcaro, Ennio Tasciotti
The advancement of nanotechnology toward more sophisticated bioinspired approaches has highlighted the gap between the advantages of biomimetic and biohybrid platforms and the availability of manufacturing processes to scale up their production. Though the advantages of transferring biological features from cells to synthetic nanoparticles for drug delivery purposes have recently been reported, a standardizable, batch-to-batch consistent, scalable, and high-throughput assembly method is required to further develop these platforms...
April 2018: Advanced Materials
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