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https://www.readbyqxmd.com/read/27920905/an-unprecedented-binuclear-cadmium-di-thio-carbamate-adduct-bis-%C3%AE-2-n-2-hydroxy-eth-yl-n-iso-propyl-carbamodi-thio-ato-%C3%AE%C2%BA-3-s-s-s-bis-n-2-hydroxy-eth-yl-n-iso-propyl-carbamodi-thio-ato-%C3%AE%C2%BA-2-s-s-3-1e-e-2-pyridin-3-yl-methyl-idene-hydrazin-1-yl-idene-meth-yl
#1
Hadi D Arman, Pavel Poplaukhin, Edward R T Tiekink
The asymmetric unit in the title binuclear compound, [Cd(C6H12NOS2)2(C12H10N4)]2·2H2O, comprises a Cd(II) atom, two di-thio-carbamate (dtc) anions, a monodentate 3-pyridine-aldazine ligand and a lattice water mol-ecule. The binuclear mol-ecule is constructed by the application of inversion symmetry. One dtc ligand simultaneously chelates one cadmium atom and bridges the centrosymmetric mate, while the other dtc ligand is chelating only. This leads to a centrosymmetric [Cd(dtc)2]2 core to which are appended two 3-pyridine-aldazine ligands...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27893349/platelet-leucocyte-and-red-cell-derived-microparticles-in-stored-whole-blood-with-and-without-leucofiltration-with-and-without-ionising-radiation
#2
Shunnichi Saito, Kenneth E Nollet, Alain M Ngoma, Takako Ono, Hitoshi Ohto
BACKGROUND: Storage lesion, including microparticle formation, has been partially characterised in whole blood, but not in all combinations of pre-storage leucofiltration and/or irradiation. MATERIALS AND METHODS: Single-donor whole blood products were processed into four subunits: with and without leucofiltration, with and without X-irradiation (25 Gy). Platelet-, leucocyte-, and erythrocyte-derived microparticles and free haemoglobin were measured periodically throughout 42 days of storage...
November 7, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27881604/cd11d-%C3%AE-2-integrin-expression-on-human-nk-b-and-%C3%AE-%C3%AE-t-cells
#3
Gabrielle M Siegers, Christy R Barreira, Lynne-Marie Postovit, Gregory A Dekaban
The CD11d integrin is expressed on the cell surface of leukocytes that belong to the myeloid lineage, but its expression on lymphocytes remains unexplored. To test the hypothesis that CD11d is expressed on lymphocyte subsets, we employed a multicolor flow cytometry panel to identify CD11d expression on B, NK, CD4(+) and CD8(+) αβ T cells (αβTc), and γδ T cells (γδTc) in human PBMC samples. CD11d was highly expressed on NK cells, B cells, and γδTc, but not αβTc. CD11d expression was higher on freshly isolated γδTc compared with αβTc from healthy donors, yet both inter- and intradonor variability was evident...
November 23, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27859480/phospholipid-bilayer-affinities-and-solvation-characteristics-by-electrokinetic-chromatography-with-a-nanodisc-pseudostationary-phase
#4
William M Penny, Harmen B Steele, J B Alexander Ross, Chistopher P Palmer
Phospholipid bilayer nanodiscs composed of 1,2-dimyristoyl-sn-glycero-3- phosphocholine and synthetic maleic acid-styrene copolymer belts have been introduced as a pseudostationary phase (PSP) in electrokinetic chromatography and demonstrated good performance. The nanodiscs provide a suitable migration range and high theoretical plate counts. Using this nanodisc PSP, the affinity of the bilayer structure for probe solutes was determined and characterized. Good correlation is observed between retention factors and octanol water partition coefficients for particular categories of solutes, but the general correlation is weak primarily because the nanodiscs show stronger affinity than octanol for hydrogen bond donors...
November 14, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27855327/evaluation-of-anaerobic-sludge-volume-for-improving-azo-dye-decolorization-in-a-hybrid-anaerobic-reactor-with-built-in-bioelectrochemical-system
#5
Min-Hua Cui, Dan Cui, Lei Gao, Ai-Jie Wang, Hao-Yi Cheng
A hybrid anaerobic reactor with built-in bioelectrochemical system (BES) has been verified for efficiently treating mixed azo dye wastewater, yet still facing many challenges, such as uncertain reactor construction and insufficient electron donors. In this study, an up-flow hybrid anaerobic reactor with built-in BES was developed for acid orange 7 (AO7) containing wastewater treatment. Cathode and real domestic wastewater both served as electron donor for driving azo dye decolorization. The decolorization efficiency (DE) of AO7 (200 mg/L) in the hybrid reactor was 80...
November 14, 2016: Chemosphere
https://www.readbyqxmd.com/read/27809289/pretransplant-levels-of-crp-and-interleukin-6-family-cytokines-effects-on-outcome-after-allogeneic-stem-cell-transplantation
#6
Tor Henrik Tvedt, Stein Atle Lie, Håkon Reikvam, Kristin Paulsen Rye, Roald Lindås, Tobias Gedde-Dahl, Aymen Bushra Ahmed, Øystein Bruserud
Several pretransplant factors, including CRP (C-reactive protein) levels, reflect the risk of complications after allogeneic stem cell transplantation. IL-6 induces CRP increase, and we therefore investigated the effects of pretransplant IL-6, soluble IL-6 receptors, IL-6 family cytokines and CRP serum levels on outcome for 100 consecutive allotransplant recipients. All patients had related donors, none had active infections and 99 patients were in complete remission before conditioning. The incidence of acute graft versus host disease (aGVHD) requiring treatment was 40%, survival at Day +100 82%, and overall survival 48%...
November 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27798170/eomeshi-nk-cells-in-human-liver-are-long-lived-and-do-not-recirculate-but-can-be-replenished-from-the-circulation
#7
Antonia O Cuff, Francis P Robertson, Kerstin A Stegmann, Laura J Pallett, Mala K Maini, Brian R Davidson, Victoria Male
Human liver contains an Eomes(hi) population of NK cells that is not present in the blood. In this study, we show that these cells are characterized by a molecular signature that mediates their retention in the liver. By examining liver transplants where donors and recipients are HLA mismatched, we distinguish between donor liver-derived and recipient-derived leukocytes to show that Eomes(lo) NK cells circulate freely whereas Eomes(hi) NK cells are unable to leave the liver. Furthermore, Eomes(hi) NK cells are retained in the liver for up to 13 y...
December 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27777018/successful-derivation-of-xeno-free-mesenchymal-stem-cell-lines-from-endometrium-of-infertile-women
#8
Tatsanee Phermthai, Kittima Tungprasertpol, Suphakde Julavijitphong, Puttachart Pokathikorn, Sasiprapa Thongbopit, Suparat Wichitwiengrat
Transplantation of mesenchymal stem cells (MSC) can effectively repair endometrial deficiencies, including infertile patients with a problem of inadequate endometrium thickness. Although, MSC derived from different organ sources have a similarity of MSC specific characteristics, endometrial stem cells (EMSC) are temporally regulated throughout the menstrual cycle in a micro-environmental niche found only in endometrial tissue. Given the micro-environment niche, developing treatments for endometrial disorders with EMSC should be a top priority...
December 2016: Reproductive Biology
https://www.readbyqxmd.com/read/27774681/frequent-whole-blood-donors-understanding-this-population-and-predictors-of-lapse
#9
Carley N Gemelli, Jane Hayman, Daniel Waller
BACKGROUND: Frequent blood donors are an important resource as they contribute many donations over their lifetime. The aim of this research was to develop a demographic profile of Australian frequent whole blood donors and to determine predictors of lapse within this group. STUDY DESIGN AND METHODS: Routinely collected data were used to profile individuals who had donated whole blood frequently (three or more times) between December 2010 and November 2011. Two segments were identified: 1) existing donors who had donated before December 2010 and 2) new donors who had not donated before December 2010...
October 23, 2016: Transfusion
https://www.readbyqxmd.com/read/27741521/s-nitrosation-on-zinc-finger-motif-of-parp-1-as-a-mechanism-of-dna-repair-inhibition-by-arsenite
#10
Xixi Zhou, Karen L Cooper, Juliana Huestis, Huan Xu, Scott W Burchiel, Laurie G Hudson, Ke Jian Liu
Arsenic, a widely distributed carcinogen, is known to significantly amplify the impact of other carcinogens through inhibition of DNA repair. Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1). AsIII-induced ROS lead to oxidation of cysteine residues within the PARP-1 zinc finger DNA binding domain. However, the mechanism underlying RNS-mediated PARP inhibition by arsenic remains unknown...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27738605/failure-of-fecal-microbiota-transplantation-in-a-three-year-old-child-with-severe-refractory-ulcerative-colitis
#11
Hideki Kumagai, Koji Yokoyama, Tomoyuki Imagawa, Shun Inoue, Janyerkye Tulyeu, Mamoru Tanaka, Takanori Yamagata
Fecal microbiota transplantation (FMT) is a treatment designed to correct gut dysbiosis by administration of feces from a healthy volunteer. It is still unclear whether FMT for children with ulcerative colitis (UC) is effective or hazardous. Here we describe a young patient to have received FMT for UC. A three-year-old girl was admitted to our hospital with severe active UC, and treated with aminosalicylates and various immunosuppressive drugs. As remission was not achieved, we decided to try FMT before colectomy...
September 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/27723455/red-blood-cell-use-in-switzerland-trends-and-demographic-challenges
#12
Thomas Volken, Andreas Buser, Damiano Castelli, Stefano Fontana, Beat M Frey, Ilka Rüsges-Wolter, Amira Sarraj, Jörg Sigle, Jutta Thierbach, Tina Weingand, Behrouz Mansouri Taleghani
BACKGROUND: Several studies have raised concerns that future demand for blood products may not be met. The ageing of the general population and the fact that a large proportion of blood products is transfused to elderly patients has been identified as an important driver of blood shortages. The aim of this study was to collect, for the first time, nationally representative data regarding blood donors and transfusion recipients in order to predict the future evolution of blood donations and red blood cell (RBC) use in Switzerland between 2014 and 2035...
September 30, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27708133/selective-inhibition-of-adam17-efficiently-mediates-glycoprotein-ib%C3%AE-retention-during-ex-vivo-generation-of-human-induced-pluripotent-stem-cell-derived-platelets
#13
Shinji Hirata, Takahiko Murata, Daisuke Suzuki, Sou Nakamura, Ryoko Jono-Ohnishi, Hidenori Hirose, Akira Sawaguchi, Satoshi Nishimura, Naoshi Sugimoto, Koji Eto
: : Donor-independent platelet concentrates for transfusion can be produced in vitro from induced pluripotent stem cells (iPSCs). However, culture at 37°C induces ectodomain shedding on platelets of glycoprotein Ibα (GPIbα), the von Willebrand factor receptor critical for adhesive function and platelet lifetime in vivo, through temperature-dependent activation of a disintegrin and metalloproteinase 17 (ADAM17). The shedding can be suppressed by using inhibitors of panmetalloproteinases and possibly of the upstream regulator p38 mitogen-activated protein kinase (p38 MAPK), but residues of these inhibitors in the final platelet products may be accompanied by harmful risks that prevent clinical application...
October 5, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27692647/the-effect-of-charged-groups-on-hydrophilic-monolithic-stationary-phases-on-their-chromatographic-properties
#14
Haibin Li, Chusheng Liu, Qiqin Wang, Haibo Zhou, Zhengjin Jiang
In order to investigate the effect of charged groups present in hydrophilic monolithic stationary phases on their chromatographic properties, three charged hydrophilic monomers, i.e. N,N-dimethyl-N-acryloyloxyethyl-N-(3-sulfopropyl)ammonium betaine (SPDA), [2-(acryloyloxy)ethyl]trimethylammonium chloride (AETA), and 3-sulfopropyl acrylate potassium salt (SPA) were co-polymerized with the crosslinker N,N'-methylenebisacrylamide (MBA), respectively. The physicochemical properties of the three resulting charged hydrophilic monolithic columns were evaluated using scanning electron microscopy, ζ-potential analysis and micro-HPLC...
October 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27660293/restoration-of-hydrogen-sulfide-production-in-diabetic-mice-improves-reparative-function-of-bone-marrow-cells
#15
Zhongjian Cheng, Venkata Naga Srikanth Garikipati, Emily Nickoloff, Chunlin Wang, David J Polhemus, Jibin Zhou, Cynthia Benedict, Mohsin Khan, Suresh K Verma, Joseph E Rabinowitz, David Lefer, Raj Kishore
BACKGROUND: Bone marrow cell (BMC)-based treatment for critical limb ischemia in diabetic patients yielded a modest therapeutic effect resulting from cell dysfunction. Therefore, approaches that improve diabetic stem/progenitor cell functions may provide therapeutic benefits. Here, we tested the hypothesis that restoration of hydrogen sulfide (H2S) production in diabetic BMCs improves their reparative capacities. METHODS: Mouse BMCs were isolated by density-gradient centrifugation...
November 8, 2016: Circulation
https://www.readbyqxmd.com/read/27650329/enhanced-in-utero-allogeneic-engraftment-in-mice-after-mobilizing-fetal-hscs-by-%C3%AE-4%C3%AE-1-7-inhibition
#16
Aimee G Kim, Jesse D Vrecenak, Matthew M Boelig, Linda Eissenberg, Michael P Rettig, John S Riley, Matthew S Holt, Michael A Conner, Stavros P Loukogeorgakis, Haiying Li, John F DiPersio, Alan W Flake, William H Peranteau
In utero hematopoietic cell transplantation (IUHCT) is a novel nonmyeloablative approach that results in donor-specific tolerance and mixed allogeneic chimerism. Clinical application is limited by low levels of donor cell engraftment. Competition from endogenous hematopoietic stem cells (HSCs) for limited "space" in fetal hematopoietic organs remains a significant barrier to successful IUHCT. AMD3100, a CXCR4 inhibitor, and firategrast, an α4β1 and α4β7 integrin inhibitor (α4β1/7), have been shown to disrupt HSC retention in the postnatal hematopoietic niche...
November 17, 2016: Blood
https://www.readbyqxmd.com/read/27644593/maintenance-of-age-in-human-neurons-generated-by-microrna-based-neuronal-conversion-of-fibroblasts
#17
Christine J Huh, Bo Zhang, Matheus B Victor, Sonika Dahiya, Luis Fz Batista, Steve Horvath, Andrew S Yoo
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that using a recently demonstrated microRNA-based cellular reprogramming approach, human fibroblasts from postnatal to near centenarian donors can be efficiently converted into neurons that maintain multiple age-associated signatures...
September 20, 2016: ELife
https://www.readbyqxmd.com/read/27642838/effect-of-nitrate-concentration-ph-and-hydraulic-retention-time-on-autotrophic-denitrification-efficiency-with-fe-ii-and-mn-ii-as-electron-donors
#18
Jun-Feng Su, Jing-Xin Shi, Ting-Lin Huang, Fang Ma, Jin-Suo Lu, Shao-Fei Yang
The role of electron donors (Fe(2+) and Mn(2+)) in the autotrophic denitrification of contaminated groundwater by bacterial strain SY6 was characterized based on empirical laboratory-scale analysis. Strain SY6 can utilize Fe(2+) more efficiently than Mn(2+) as an electron donor. This study has shown that the highest nitrate removal ratio, observed with Fe(2+) as the electron donor, was approximately 88.89%. An immobilized biological filter reactor was tested by using three levels of influent nitrate (10, 30, and 50 mg/L), three pH levels (6, 7, and 8), and three levels of hydraulic retention time (HRT; 6, 8, and 12 h), respectively...
September 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27625675/a-natural-light-dark-cycle-regulation-of-carbon-nitrogen-metabolism-and-gene-expression-in-rice-shoots
#19
Haixing Li, Zhijun Liang, Guangda Ding, Lei Shi, Fangsen Xu, Hongmei Cai
Light and temperature are two particularly important environmental cues for plant survival. Carbon and nitrogen are two essential macronutrients required for plant growth and development, and cellular carbon and nitrogen metabolism must be tightly coordinated. In order to understand how the natural light/dark cycle regulates carbon and nitrogen metabolism in rice plants, we analyzed the photosynthesis, key carbon-nitrogen metabolites, and enzyme activities, and differentially expressed genes and miRNAs involved in the carbon and nitrogen metabolic pathway in rice shoots at the following times: 2:00, 6:00, 10:00, 14:00, 18:00, and 22:00...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27620954/folylpoly-%C3%AE-glutamate-synthetase-a-key-determinant-of-folate-homeostasis-and-antifolate-resistance-in-cancer
#20
Shachar Raz, Michal Stark, Yehuda G Assaraf
Mammalians are devoid of autonomous biosynthesis of folates and hence must obtain them from the diet. Reduced folate cofactors are B9-vitamins which play a key role as donors of one-carbon units in the biosynthesis of purine nucleotides, thymidylate and amino acids as well as in a multitude of methylation reactions including DNA, RNA, histone and non-histone proteins, phospholipids, as well as intermediate metabolites. The products of these S-adenosylmethionine (SAM)-dependent methylations are involved in the regulation of key biological processes including transcription, translation and intracellular signaling...
September 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
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