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https://www.readbyqxmd.com/read/28208057/vertical-alveolar-distraction-osteogenesis-of-the-atrophic-posterior-mandible-before-dental-implant-insertion
#1
Adi Rachmiel, Dekel Shilo, Dror Aizenbud, Omri Emodi
PURPOSE: Augmentation of deficient mandibular posterior alveolar ridges poses a great challenge because of extensive bone deficiency and the presence of the inferior alveolar nerve. This study sets its focus on vertical alveolar distraction osteogenesis (ADO) at the posterior mandible before dental implant placement. MATERIALS AND METHODS: The study included 21 sites in 18 patients with severe mandibular posterior alveolar ridge deficiency. A trapezoidal osteotomy was performed, and an extraosseous alveolar distraction device was fixed and activated after a 4-day latency period at a rate of 0...
January 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28198077/translation-strategies-contradiction-and-the-theory-of-social-representations-why-discussing-needles-may-improve-blood-donor-retention
#2
Gail Moloney, Jane Hayman, Marguerite Gamble, Geoff Smith, Rob Hall
Retaining blood donors is a cost-effective way of ensuring a safe blood supply, yet despite the plethora of research, only 5.1% of the eligible population in Australia donate blood and 40% of these do not make a second donation. We offer an alternative to traditional approaches by conceptualizing blood donation within social representations theory as socially derived symbolic knowledge with a specific focus on cognitive polyphasia and Guimelli's (1998) normative and functional dimensions. An online survey, completed by 703 residents from NSW Australia, comprised a blood donation word association task, Likert-style questions constructed from previous word association data and contextualized blood donation statements...
February 15, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28194142/respiratory-ammonification-of-nitrate-coupled-to-anaerobic-oxidation-of-elemental-sulfur-in-deep-sea-autotrophic-thermophilic-bacteria
#3
Galina B Slobodkina, Andrey V Mardanov, Nikolai V Ravin, Anastasia A Frolova, Nikolay A Chernyh, Elizaveta A Bonch-Osmolovskaya, Alexander I Slobodkin
Respiratory ammonification of nitrate is the microbial process that determines the retention of nitrogen in an ecosystem. To date, sulfur-dependent dissimilatory nitrate reduction to ammonium has been demonstrated only with sulfide as an electron donor. We detected a novel pathway that couples the sulfur and nitrogen cycles. Thermophilic anaerobic bacteria Thermosulfurimonas dismutans and Dissulfuribacter thermophilus, isolated from deep-sea hydrothermal vents, grew autotrophically with elemental sulfur as an electron donor and nitrate as an electron acceptor producing sulfate and ammonium...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28183597/preparation-and-characterization-of-dox-loaded-keratin-nanoparticles-for-ph-gsh-dual-responsive-release
#4
Yanmei Li, Xuelian Zhi, Jiantao Lin, Xin You, Jiang Yuan
Smart drug carriers are the current need of the hour in controlled drug delivery applications. In this work, pH and redox dual responsive keratin based drug-loaded nanoparticles (KDNPs) were fabricated through two-step strategies. Keratin nanoparticles were first prepared by desolvation method and chemical crosslinking, followed by electrostatic adsorbing doxorubicin (DOX) to afford drug loaded keratin nanoparticles (KDNPs). The size, size distribution, and morphology of the KDNPs were characterized with dynamic light scattering (DLS) and Scan electronic microscope (SEM)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28182624/socio-demographic-characteristics-of-danish-blood-donors
#5
Kristoffer Sølvsten Burgdorf, Jacob Simonsen, Anna Sundby, Klaus Rostgaard, Ole Birger Pedersen, Erik Sørensen, Kaspar René Nielsen, Mie Topholm Bruun, Morten Frisch, Gustaf Edgren, Christian Erikstrup, Henrik Hjalgrim, Henrik Ullum
BACKGROUND: Blood transfusion is an essential component of a modern healthcare system. Because knowledge about blood donor demography may inform the design of strategies for donor recruitment and retention, we used nationwide registers to characterize the entire population of blood donors in Denmark in 2010. METHODS: The study population comprised all Danes in the age range eligible for blood donation (N = 3,236,753) at the end of 2010. From the Scandinavian Donations and Transfusions (SCANDAT) register, we identified 174,523 persons who donated blood in Danish blood banks at least once in 2010...
2017: PloS One
https://www.readbyqxmd.com/read/28168852/hemoglobin-screening-in-blood-donors-a-prospective-study-assessing-the-value-of-an-invasive-and-a-noninvasive-point-of-care-device-for-donor-safety
#6
Dorien De Clippel, Leen Van Heddegem, Giovani Vandewalle, Philippe Vandekerckhove, Veerle Compernolle
BACKGROUND: Low hemoglobin (Hb) levels are a common reason for whole blood donor deferral. As some of the deferred donors do not return to donate blood later, the development of accurate tools to reliably detect low Hb levels is therefore important for donor safety and retention. STUDY DESIGN AND METHODS: In a prospective study, 1483 whole blood donors were enrolled in three study arms. In each study arm the Hb results measured with a point-of-care testing device were compared with the venous Hb results obtained in our central laboratory...
February 6, 2017: Transfusion
https://www.readbyqxmd.com/read/28133899/effect-of-water-on-the-retention-on-diol-and-amide-columns-in-hydrophilic-interaction-liquid-chromatography
#7
Pavel Jandera, Petr Janás, Veronika Škeříková, Jiří Urban
The amount of water adsorbed on polar columns plays important role in hydrophilic interaction liquid chromatography. It may strongly differ for individual types of polar columns used in this separation mode. We measured adsorption isotherms of water on an amide and three diol bonded stationary phases that differ in the chemistry of the bonded ligands and properties of the silica gel support. We studied the effects of the adsorbed water on the retention of aromatic carboxylic acids, flavonoids, benzoic acid derivatives, nucleic bases and nucleosides in aqueous-acetonitrile mobile phases over the full composition range...
January 29, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28125805/characterization-of-an-acellular-scaffold-for-a-tissue-engineering-approach-to-the-nipple-areolar-complex-reconstruction
#8
Nicholas C Pashos, Michelle E Scarritt, Zachary R Eagle, Jeffrey M Gimble, Abigail E Chaffin, Bruce A Bunnell
A significant number of patients undergo mastectomies and breast reconstructions every year using many surgical-based techniques to reconstruct the nipple-areolar complex (NAC). Described herein is a tissue engineering approach that may permit a human NAC onlay graft during breast reconstruction procedures. By applying decellularization, which is the removal of cellular components from tissue, to an intact whole donor NAC, the extracellular matrix (ECM) structure of the NAC is preserved. This creates a biologically derived scaffold for cells to repopulate and regenerate the NAC...
January 27, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28102070/well-ordered-oxygen-deficient-comoo4-and-fe2o3-nanoplate-arrays-on-3d-graphene-foam-towards-flexible-asymmetric-supercapacitor-with-enhanced-capacitive-properties
#9
Kai Chi, Zheye Zhang, Qi-Ying Lv, Chuyi Xie, Jian Xiao, Fei Xiao, Shuai Wang
In this work, we report the development of well-ordered hydrogenated CoMoO4 (H-CoMoO4) and hydrogenated Fe2O3 (H-Fe2O3) nanoplate arrays on 3D graphene foam (GF), and explore their practice application as binder-free electrodes in assembling flexible all-solid-state asymmetric supercapacitor (ASC) device. Our results show that the monolithic 3D porous GF prepared by solution casting method using Ni foam template possesses large surface area, superior electrical conductivity, and sufficient surface functional groups, which not only facilitate in situ growth of CoMoO4 and Fe2O3 nanoplates on it, but also contribute the double-layer capacitance of resultant supercapacitor...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28051363/effects-of-hydraulic-retention-time-and-formula-see-text-ratio-on-thiosulfate-driven-autotrophic-denitrification-for-nitrate-removal-from-micro-polluted-surface-water
#10
Zheng Wang, Xiang Fei, Sheng-Bing He, Jung-Chen Huang, Wei-Li Zhou
This study was carried out to investigate the possibility of a thiosulfate-driven autotrophic denitrification for nitrate-N removal from micro-polluted surface water. The aim was to study the effects of [Formula: see text] ratio (S/N molar ratio) and hydraulic retention time (HRT) on the autotrophic denitrification performance. Besides, utilization efficiencies of [Formula: see text] along the biofilter and the restart-up of the bioreactor were also investigated. Autotrophic denitrification using thiosulfate as an electron donor for treating micro-polluted surface water without the addition of external alkalinity proved to be feasible and the biofilter could be readied in two weeks...
January 18, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28049741/integrating-omics-and-alternative-splicing-reveals-insights-into-grape-response-to-high-temperature
#11
Jianfu Jiang, Xinna Liu, Guotian Liu, Chonghuai Liu, Shaohua Li, Lijun Wang
Heat stress is one of the primary abiotic stresses that limit crop production. Grape is a cultivated fruit with high economic value throughout the world, with its growth and development often influenced by high temperature. Alternative splicing (AS) is a widespread phenomenon increasing transcriptome and proteome diversity. We conducted high temperature treatments (35oC, 40oC and 45oC) on grapevines (Vitis vinifera), and assessed transcriptomic (especially AS) and proteomic changes in leaves. We found that nearly 70% of the genes were alternatively spliced under high temperature...
January 3, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28041753/modified-reversed-superficial-peroneal-artery-flap-in-the-reconstruction-of-ankle-and-foot-defects-following-severe-burns-or-trauma
#12
Shi-Ji Li, Hao Cheng, Xu Fang, Jian-Yang Xu, Fei Wang, Sheng Liu, Xu-Lin Chen, Xiong-Wen Lv
OBJECTIVE: Challenges persist in the reconstruction of the ankle and the foot with exposed tendons, joints, and bones as a result of severe burns and trauma. In flap elevation involving the sensitive superficial nerve, the local nerve was always sacrificed to obtain an anesthetic donor site; however, such a procedure introduced the possibility of painful neuromas. In this study, we present a desired clinical application of a modified reversed superficial peroneal artery flap, in which the superficial peroneal nerve is preserved...
December 29, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28033465/diketopyrrolopyrrole-triphenylamine-organic-nanoparticles-as-multifunctional-reagents-for-photoacoustic-imaging-guided-photodynamic-photothermal-synergistic-tumor-therapy
#13
Yu Cai, Pingping Liang, Qianyun Tang, Xiaoyan Yang, Weili Si, Wei Huang, Qi Zhang, Xiaochen Dong
Herein, a donor-acceptor-donor (D-A-D) structured small molecule (DPP-TPA) is designed and synthesized for photoacoustic imaging (PAI) guided photodynamic/photothermal synergistic therapy. In the diketopyrrolopyrrole (DPP) molecule, a thiophene group is contained to increase the intersystem crossing (ISC) ability through the heavy atom effect. Simultaneously, triphenylamine (TPA) is introduced for bathochromic shift absorption as well as charge transport capacity enhancement. After formation of nanoparticles (NPs, ∼76 nm) by reprecipitation, the absorption of DPP-TPA NPs further displays obvious bathochromic-shift with the maximum absorption peak at 660 nm...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28027576/human-macrophage-ferroportin-biology-and-the-basis-for-the-ferroportin-disease
#14
Manuela Sabelli, Giuliana Montosi, Cinzia Garuti, Angela Caleffi, Stefania Oliveto, Stefano Biffo, Antonello Pietrangelo
: Ferroportin (FPN1) is the sole iron-exporter in mammals but its cell-specific function and regulation are still elusive. This study aims at studying FPN1 expression in human macrophages, the cells that mostly contribute on a daily basis to plasma iron turnover and are central in the pathogenesis of the disease due to lack-of-function FPN1 mutations, the Ferroportin Disease (FD). We characterized FPN1 protein expression and traffic by confocal microscopy, western blot, gel-filtration and immunoprecipitation studies in macrophages from blood donors and patients with either FPN1 p...
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28024356/ultrasound-triggered-nitric-oxide-release-platform-based-on-energy-transformation-for-targeted-inhibition-of-pancreatic-tumor
#15
Kun Zhang, Huixiong Xu, Xiaoqing Jia, Yu Chen, Ming Ma, Liping Sun, Hangrong Chen
Inspired by considerable application potential in various diseases, nitric oxide (NO) has gained increasing attention. Nevertheless, current NO release scaffolds suffer from some inevitable drawbacks, for example, high toxicity for NO donor byproducts, poor specificity, shallow penetration depth, and strong ionizing irradiation for triggers, all of which remain obstacles to clinical application. Herein, an ultrasound-triggered NO on-demand release system is constructed using natural l-arginine as NO donor and local ultrasound as trigger...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28011613/spinal-arachnoiditis-as-a-complication-of-cryptococcal-meningoencephalitis-in-non-hiv-previously-healthy-adults
#16
Anil A Panackal, Mika Komori, Peter Kosa, Omar Khan, Dima A Hammoud, Lindsey B Rosen, Sarah K Browne, Yen-Chih Lin, Elena Romm, Charu Ramaprasad, Bettina C Fries, John E Bennett, Bibiana Bielekova, Peter R Williamson
BACKGROUND: Cryptococcus can cause meningoencephalitis (CM) among previously healthy non-HIV adults. Spinal arachnoiditis is under-recognized, since diagnosis is difficult with concomitant central nervous system (CNS) pathology. METHODS: We describe 6 cases of spinal arachnoiditis among 26 consecutively recruited CM patients with normal CD4 counts who achieved microbiologic control. We performed detailed neurological exams, cerebrospinal fluid (CSF) immunophenotyping and biomarker analysis before and after adjunctive immunomodulatory intervention with high dose pulse corticosteroids, affording causal inference into pathophysiology...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28009814/a-novel-pathogenic-brca1-splicing-variant-produces-partial-intron-retention-in-the-mature-messenger-rna
#17
Maria Valeria Esposito, Marcella Nunziato, Flavio Starnone, Antonella Telese, Alessandra Calabrese, Giuseppe D'Aiuto, Pietro Pucci, Massimiliano D'Aiuto, Francisco Baralle, Valeria D'Argenio, Francesco Salvatore
About 10% of all breast cancers arise from hereditary mutations that increase the risk of breast and ovarian cancers; and about 25% of these are associated with the BRCA1 or BRCA2 genes. The identification of BRCA1/BRCA2 mutations can enable physicians to better tailor the clinical management of patients; and to initiate preventive measures in healthy carriers. The pathophysiological significance of newly identified variants poses challenges for genetic counseling. We characterized a new BRCA1 variant discovered in a breast cancer patient during BRCA1/2 screening by next-generation sequencing...
December 21, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27989855/formulation-and-evaluation-of-chitosan-polyethylene-oxide-nanofibers-loaded-with-metronidazole-for-local-infections
#18
Špela Zupančič, Tanja Potrč, Saša Baumgartner, Petra Kocbek, Julijana Kristl
Nanofibers combined with an antimicrobial represent a powerful strategy for treatment of various infections. Local infections usually have a low fluid volume available for drug release, whereas pharmacopoeian dissolution tests include a much larger receptor volume. Therefore, the development of novel drug-release methods that more closely resemble the in-vivo conditions is necessary. We first developed novel biocompatible and biodegradable chitosan/polyethylene oxide nanofibers using environmentally friendly electrospinning of aqueous polymer solutions, with the inclusion of the antimicrobial metronidazole...
October 29, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27984397/donor-screening-experience-for-fecal-microbiota-transplantation-in-patients-with-recurrent-c-difficile-infection
#19
Raseen Tariq, Renee Weatherly, Patricia Kammer, Darrell S Pardi, Sahil Khanna
GOALS: To evaluate our experience with stool donor recruitment, screening, retention, and donor perception for fecal microbiota transplantation (FMT). BACKGROUND: Multiply recurrent Clostridium difficile infection is being increasingly managed with FMT from donor stools. However, donor selection and recruitment is challenging due to lack of standard evidence-based guidelines, donor exclusion criteria, frequency of screening and donor commitment. METHODS: Data on donors screened using institutional guidelines with history, blood and stool testing and their perspectives on donation were analyzed...
December 14, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27979752/applying-self-determination-theory-to-the-blood-donation-context-the-blood-donor-competence-autonomy-and-relatedness-enhancement-blood-donor-care-trial
#20
Christopher R France, Janis L France, Bruce W Carlson, Victoria Frye, Louisa Duffy, Debra A Kessler, Mark Rebosa, Beth H Shaz
The Blood Donor Competency, Autonomy, and Relatedness Enhancement (Blood Donor CARE) project was designed as a practical application of self-determination theory to encourage retention of first-time donors. Self-determination theory proposes that people are more likely to persist with behaviors that are internally-motivated, and that externally-motivated behavior can evolve and become internalized given the appropriate socio-environmental conditions. According to self-determination theory, motivation to engage in blood donation may become increasingly self-determined if the behavior satisfies fundamental human needs for competence (a sense of self-efficacy to achieve specific goals), autonomy (a sense of volitional control over one's behavior), and relatedness (a sense of connection to a larger group)...
February 2017: Contemporary Clinical Trials
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