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https://www.readbyqxmd.com/read/28531951/identifying-and-quantifying-geochemical-and-mixing-processes-in-the-matanza-riachuelo-aquifer-system-argentina
#1
S Armengol, M Manzano, S A Bea, S Martínez
The Matanza-Riachuelo River Basin, in the Northeast of the Buenos Aires Province, is one of the most industrialized and populated region in Argentina and it is worldwide known for its alarming environmental degradation. In order to prevent further damages, the aquifer system, which consists of two overlaid aquifers, is being monitored from 2008 by the river basin authority, Autoridad de la Cuenca Matanza-Riachuelo. The groundwater chemical baseline has been established in a previous paper (Zabala et al., 2016), and this one is devoted to the identification of the main physical and hydrogeochemical processes that control groundwater chemistry and its areal distribution...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28530772/characteristics-of-the-injuries-of-syrian-refugees-sustained-during-the-civil-war
#2
Betül Kocamer Şimşek, Mehmet Dokur, Erdal Uysal, Necdet Çalıker, Oruç Numan Gökçe, İbrahim Kürşat Deniz, Murat Uğur, Murat Geyik, Mehmet Kaya, Güner Dağlı
BACKGROUND: During a war, many civilians are severely injured by firearms, bombs, and shrapnel. The triage of war injuries involves difficult and complicated processes requiring surgical procedures and patient monitoring in the Intensive Care Unit (ICU) of hospitals. In this study, we examine the demographic, traumatic, and critical care characteristics of cases injured during the civil war in Syria and requiring emergency surgery. METHODS: Electronic data of the traumatic, surgical, and ICU monitoring features of 707 patients admitted to Kilis Public Hospital between March 2012 and January 2013 were analyzed retrospectively RESULTS: Most of the patients reported having been injured due to firearms (83...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28525847/apoptosis-of-leukemia-k562-and-molt-4-cells-induced-by-emamectin-benzoate-involving-mitochondrial-membrane-potential-loss-and-intracellular-ca-2-modulation
#3
Xinming Yun, Wenbing Rao, Ciying Xiao, Qingchun Huang
Leukemia threatens millions of people's health and lives, and the pesticide-induced leukemia has been increasingly concerned because of the etiologic exposure. In this paper, cytotoxic effect of emamectin benzoate (EMB), an excellent natural-product insecticide, was evaluated through monitoring cell viability, cell apoptosis, mitochondrial membrane potential and intracellular Ca(2+) concentration ([Ca(2+)]i) in leukemia K562 and Molt-4 cells. Following the exposure to EMB, cell viability was decreased and positive apoptosis of K562 and Molt-4 cells was increased in a concentration- and time- dependent fashion...
April 19, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28513323/modulation-of-somatoparaphrenia-following-left-hemisphere-damage
#4
Daniela D'Imperio, Giampaolo Tomelleri, Giuseppe Moretto, Valentina Moro
Somatoparaphrenic symptoms after left-hemisphere damage are rare. To verify the potential role of body-related sensory (proprioceptive, visual, and somatosensory) manipulation in patients experiencing sensations of hand disownership, the symptoms of a patient suffering from right-hand somatoparaphrenia were monitored and clinical and neuropsychological variables were controlled. Four types of manipulation were administered: changes in spatial position of the hand, multisensory stimulation, and self-observation using video or mirrors...
May 17, 2017: Neurocase
https://www.readbyqxmd.com/read/28512753/serum-neurofilament-light-a-biomarker-of-neuronal-damage-in-multiple-sclerosis
#5
Giulio Disanto, Christian Barro, Pascal Benkert, Yvonne Naegelin, Sabine Schädelin, Antonella Giardiello, Chiara Zecca, Kaj Blennow, Henrik Zetterberg, David Leppert, Ludwig Kappos, Claudio Gobbi, Jens Kuhle
OBJECTIVE: Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the CSF and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in MS. METHODS: sNfL levels were measured in healthy controls (HC, n=254) and two independent MS cohorts: (1) cross-sectional with paired serum and CSF samples (n=142); (2) longitudinal with repeated serum sampling (n=246, median (IQR) follow-up 3...
May 16, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28511498/antioxidant-oxidant-index-as-a-biomarker-in-oral-potentially-malignant-disorders-and-oral-squamous-cell-carcinoma-a-biochemical-study
#6
Saurabh Juneja, Ajit Singh Rathore, Kanika Sharma, Devicharan Shetty, Anshi Jain
INTRODUCTION: Oxidative stress has been implicated in tumourigenesis by affecting the actions of various protein kinases and transcription factors, and resulting in damage to DNA structure by the deamination of nucleotides and the generation of free radicals. Derangements in the antioxidant defence mechanism have been considered in the pathogenesis of oral cancer. AIM: To evaluate and compare the serum levels of nitric oxide and vitamin C in cases of Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCC) and healthy controls...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509355/lon-protease-modulates-virulence-traits-in-erwinia-amylovora-by-directly-monitoring-major-regulators-and-indirectly-through-the-rcs-and-gac-csr-regulatory-systems
#7
Jae Hoon Lee, Veronica Ancona, Youfu Zhao
Lon, an ATP-dependent protease in bacteria, influences diverse cellular processes by degrading damaged, misfolded and short-lived regulatory proteins. In this study, we characterized the effects of lon mutation and determined the molecular mechanisms underlying Lon-mediated virulence regulation in Erwinia amylovora, an enterobacterial pathogen of apple. E. amylovora depends on the type III secretion system (T3SS) and the exopolysaccharide (EPS) amylovoran to cause disease. Our results showed that mutation of the lon gene led to overproduction of amylovoran, increased T3SS gene expression and non-motile phenotype...
May 16, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28504828/improvement-in-solvent-tolerance-by-exogenous-glycerol-in-pseudomonas-sp-bcnu-106
#8
Hye Jung Choi, Bo Ra Lim, Yeo Jin Park, Woo Hong Joo
Solvent hyper-tolerant Pseudomonas sp. BCNU 106 still has some underlying growth limitation in solvents. Therefore, efficient mass cultivation methods are needed to pursue its applications in biotechnology. Pseudomonas sp. BCNU 106 was cultured in a medium supplemented with 0.05 mol l(-1) glycerol and cell survival was monitored during its cultivation in the presence of 1% (v/v) toluene. Exogenously-supplemented glycerol provided more protection against damage caused by toluene stress and conferred higher solvent tolerance of Pseudomonas sp...
May 15, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28497934/cerebral-autoregulation-monitoring-in-acute-traumatic-brain-injury-what-s-the-evidence
#9
Leanne A Calviello, Joseph Donnelly, Frederick A Zeiler, Eric P Thelin, Peter Smielewski, Marek Czosnyka
Cerebral autoregulation is conceptualized as a vascular self-regulatory mechanism within the brain. Controlled by elusive relationships between various biophysical processes, it functions to protect the brain against potential damages caused by sudden changes in cerebral perfusion pressures and flow. Following events such as traumatic brain injuries (TBI), autoregulation may be compromised, potentially leading to an unfavorable outcome. In spite of its complexity, autoregulation has been able to be quantified non-invasively within the neuro-critical care setting with the aid of transcranial Doppler...
May 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28491065/osphyb-mediating-novel-regulatory-pathway-for-drought-tolerance-in-rice-root-identified-by-a-global-rna-seq-transcriptome-analysis-of-rice-genes-in-response-to-water-deficiencies
#10
Yo-Han Yoo, Anil K Nalini Chandran, Jong-Chan Park, Yun-Shil Gho, Sang-Won Lee, Gynheung An, Ki-Hong Jung
Water deficiencies are one of the most serious challenges to crop productivity. To improve our understanding of soil moisture stress, we performed RNA-Seq analysis using roots from 4-week-old rice seedlings grown in soil that had been subjected to drought conditions for 2-3 d. In all, 1,098 genes were up-regulated in response to soil moisture stress for 3 d, which causes severe damage in root development after recovery, unlikely that of 2 d. Comparison with previous transcriptome data produced in drought condition indicated that more than 68% of our candidate genes were not previously identified, emphasizing the novelty of our transcriptome analysis for drought response in soil condition...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28491039/daily-moderate-exercise-is-beneficial-and-social-stress-is-detrimental-to-disease-pathology-in-murine-lupus-nephritis
#11
Saba I Aqel, Jeffrey M Hampton, Michael Bruss, Kendra T Jones, Giancarlo R Valiente, Lai-Chu Wu, Matthew C Young, William L Willis, Stacy Ardoin, Sudha Agarwal, Brad Bolon, Nicole Powell, John Sheridan, Naomi Schlesinger, Wael N Jarjour, Nicholas A Young
Daily moderate exercise (DME) and stress management are underemphasized in the care of patients with lupus nephritis (LN) due to a poor comprehensive understanding of their potential roles in controlling the inflammatory response. To investigate these effects on murine LN, disease progression was monitored with either DME or social disruption stress (SDR) induction in NZM2410/J mice, which spontaneously develop severe, early-onset LN. SDR of previously established social hierarchies was performed daily for 6 days and DME consisted of treadmill walking (8...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28481908/effect-of-intravenous-immunoglobulin-on-the-function-of-treg-cells-derived-from-immunosuppressed-mice-with-pseudomonas-aeruginosa-pneumonia
#12
Junlu Li, Tingsang Chen, Congcong Yuan, Guoqiang Zhao, Min Xu, Xiaoyan Li, Jie Cao, Lihua Xing
AIM: The present study aimed to investigate the effect of intravenous immunoglobulin (IVIG) on regulatory T (Treg) cells derived from immunosuppressed mice with Pseudomonas aeruginosa (PA) pneumonia. METHODS: A total of 108 BALB/c mice were randomly divided into the following groups: control group (Control), immunosuppressed group (IS), PA pneumonia group (PA), PA pneumonia in immunosuppressed group (IS + PA), PA pneumonia with IVIG treatment in immunocompetent group (PA + IVIG) and PA pneumonia with IVIG treatment in immunosuppressed group (IS + PA + IVIG)...
2017: PloS One
https://www.readbyqxmd.com/read/28477129/phenotypic-analysis-of-atm-protein-kinase-in-dna-double-strand-break-formation-and-repair
#13
Elisabeth Mian, Lisa Wiesmüller
Ataxia telangiectasia mutated (ATM) encodes a serine/threonine protein kinase, which is involved in various regulatory processes in mammalian cells. Its best-known role is apical activation of the DNA damage response following generation of DNA double-strand breaks (DSBs). When DSBs appear, sensor and mediator proteins are recruited, activating transducers such as ATM, which in turn relay a widespread signal to a multitude of downstream effectors. ATM mutation causes Ataxia telangiectasia (AT), whereby the disease phenotype shows differing characteristics depending on the underlying ATM mutation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28477057/real-time-prediction-of-temperature-elevation-during-robotic-bone-drilling-using-the-torque-signal
#14
Arne Feldmann, Kate Gavaghan, Manuel Stebinger, Tom Williamson, Stefan Weber, Philippe Zysset
Bone drilling is a surgical procedure commonly required in many surgical fields, particularly orthopedics, dentistry and head and neck surgeries. While the long-term effects of thermal bone necrosis are unknown, the thermal damage to nerves in spinal or otolaryngological surgeries might lead to partial paralysis. Previous models to predict the temperature elevation have been suggested, but were not validated or have the disadvantages of computation time and complexity which does not allow real time predictions...
May 5, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28475469/higher-ambulatory-systolic-blood-pressure-independently-associated-with-enlarged-perivascular-spaces-in-basal-ganglia
#15
Shuna Yang, Junliang Yuan, Xiaoyu Zhang, Huimin Fan, Yue Li, Jiangmei Yin, Wenli Hu
BACKGROUNDS: Enlarged perivascular spaces (EPVS) have been identified as a marker of cerebral small vessel diseases (CSVD). Ambulatory blood pressure (ABP) is the strongest predictor of hypertension-related brain damage. However, the relationship between ABP levels and EPVS is unclear. OBJECTIVES: This study aimed to investigate the association between ABP levels and EPVS by 24-hour ambulatory blood pressure monitoring (ABPM). METHODS: We prospectively recruited inpatients for physical examinations in our hospital from May 2013 to Jun 2016...
May 5, 2017: Neurological Research
https://www.readbyqxmd.com/read/28475168/deformation-monitoring-of-waste-rock-backfilled-mining-gob-for-ground-control
#16
Tongbin Zhao, Yubao Zhang, Zhenyu Zhang, Zhanhai Li, Shuqi Ma
Backfill mining is an effective option to mitigate ground subsidence, especially for mining under surface infrastructure, such as buildings, dams, rivers and railways. To evaluate its performance, continual long-term field monitoring of the deformation of backfilled gob is important to satisfy strict public scrutiny. Based on industrial Ethernet, a real-time monitoring system was established to monitor the deformation of waste-rock-backfilled gob at -700 m depth in the Tangshan coal mine, Hebei Province, China...
May 5, 2017: Sensors
https://www.readbyqxmd.com/read/28473308/sa%C3%A3%C2%BAde-na-copa-the-world-s-first-application-of-participatory-surveillance-for-a-mass-gathering-at-fifa-world-cup-2014-brazil
#17
Onicio Leal Neto, George Santiago Dimech, Marlo Libel, Wayner Vieira de Souza, Eduarda Cesse, Mark Smolinski, Wanderson Oliveira, Jones Albuquerque
BACKGROUND: The 2005 International Health Regulations (IHRs) established parameters for event assessments and notifications that may constitute public health emergencies of international concern. These requirements and parameters opened up space for the use of nonofficial mechanisms (such as websites, blogs, and social networks) and technological improvements of communication that can streamline the detection, monitoring, and response to health problems, and thus reduce damage caused by these problems...
May 4, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28472342/the-non-stop-decay-mrna-surveillance-pathway-is-required-for-oxidative-stress-tolerance
#18
Nur H Jamar, Paraskevi Kritsiligkou, Chris M Grant
Reactive oxygen species (ROS) are toxic by-products of normal aerobic metabolism. ROS can damage mRNAs and the translational apparatus resulting in translational defects and aberrant protein production. Three mRNA quality control systems monitor mRNAs for translational errors: nonsense-mediated decay, non-stop decay (NSD) and no-go decay (NGD) pathways. Here, we show that factors required for the recognition of NSD substrates and components of the SKI complex are required for oxidant tolerance. We found an overlapping requirement for Ski7, which bridges the interaction between the SKI complex and the exosome, and NGD components (Dom34/Hbs1) which have been shown to function in both NSD and NGD...
May 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28470591/high-intensity-interval-training-in-facioscapulohumeral-muscular-dystrophy-type-1-a-randomized-clinical-trial
#19
Grete Andersen, Karen Heje, Astrid Emile Buch, John Vissing
Increasing evidence suggests that high-intensity training (HIT) is a time-efficient exercise strategy to improve fitness. HIT has never been explored in neuromuscular diseases, likely because it may seem counterintuitive. A single session of high-intensity exercise has been studied without signs of muscle damage in facioscapulohumeral muscular dystrophy type 1 (FSHD1). We aimed to determine whether HIT is safe and effective in FSHD1 in a randomized, controlled parallel study. Untrained adults with genetically verified FSHD1 (n = 13) able to perform cycle-ergometer exercise were randomized to 8 weeks of supervised HIT (n = 6) (3 × 10-min cycle-ergometer-HIT/week) or 8 weeks of usual care (n = 7)...
May 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28464973/evaluation-of-fipronil-and-imidacloprid-as-bait-active-ingredients-against-fungus-growing-termites-blattodea-termitidae-macrotermitinae
#20
N Iqbal, T A Evans
Fungus-growing termites (Macrotermitinae) are important pests in tropical countries. They are difficult to control with existing baiting methods, as chitin synthesis inhibitors are not effectual as active ingredients. We tested two neurotoxins, fipronil and imidacloprid, as potential bait active ingredients against Macrotermes gilvus (Hagen) in Singapore. In laboratory bioassays, M. gilvus showed no preference for doses of 0-64 ppm fipronil, or for doses of 0-250 ppm imidacloprid, indicating no repellence. We tested each insecticide in toilet paper as a bait matrix in a field experiment...
May 3, 2017: Bulletin of Entomological Research
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