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https://www.readbyqxmd.com/read/29671690/application-of-a-novel-murine-ear-vein-model-to-evaluate-the-effects-of-a-vascular-radioprotectant-on-radiation-induced-vascular-permeability-and-leukocyte-adhesion
#1
Kathleen A Ashcraft, Kingshuk Roy Choudhury, Sam R Birer, Hansford C Hendargo, Pranalee Patel, Gary Eichenbaum, Mark W Dewhirst
Vascular injury after radiation exposure contributes to multiple types of tissue injury through a cascade of events. Some of the earliest consequences of radiation damage include increased vascular permeability and promotion of inflammation, which is partially manifested by increased leukocyte-endothelial (L/E) interactions. We describe herein a novel intravital imaging method to evaluate L/E interactions, as a function of shear stress, and vascular permeability at multiple time points after local irradiation to the ear...
April 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29671042/hyperbaric-oxygen-therapy-reduces-astrogliosis-and-helps-to-recovery-brain-damage-in-hydrocephalic-young-rats
#2
Stephanya Covas da Silva, Omar Feres, Pâmella da Silva Beggiora, Hélio Rubens Machado, Rafael Menezes-Reis, João Eduardo Araújo, Ricardo Andrade Brandão, Luiza da Silva Lopes
PURPOSE: We investigated the possible beneficial effects that hyperbaric oxygen therapy could offer in different brain structures affected by ventriculomegaly in pup rats submitted to experimental hydrocephalus. METHODS: Seven-day-old Wistar rats were submitted to hydrocephalus by intracisternal injection of 10% kaolin into the cisterna magna. The animals were divided into four groups: control (n = 5); control with HBOT (3ATA/2 h/day) (n = 5); untreated hydrocephalic (n = 10); hydrocephalic treated with HBOT (3ATA/2 h/day) (n = 10)...
April 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29670339/twenty-four-hour-systolic-blood-pressure-variability-and-renal-function-decline-in-elderly-male-hypertensive-patients-with-well-controlled-blood-pressure
#3
Xi Wang, Fan Wang, Minzhi Chen, Xiaona Wang, Jin Zheng, Aimei Qin
Purpose: Increased variability in blood pressure (BP) is known to be closely associated with the development, progression and severity of renal damage in patients with chronic kidney disease. However, little is known about the association of BP variability (BPV) with the decline of renal function in elderly hypertensive patients with well-controlled BP. We, therefore, aimed to investigate the association between BPV and glomerular filtration rate in hypertensive elderly (age >60 years) and very elderly (age >80 years) male patients with BP controlled within the normal range by antihypertensive therapy...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29667748/accumulation-and-sublethal-effects-of-triclosan-and-its-transformation-product-methyl-triclosan-in-the-earthworm-eisenia-andrei-exposed-to-environmental-concentrations-in-an-artificial-soil
#4
Fanny Chevillot, Mélanie Guyot, Mélanie Desrosiers, Nicole Cadoret, Éloïse Veilleux, Hubert Cabana, Jean-Philippe Bellenger
Municipal biosolids are increasingly used as a low-cost fertilizer in agricultural soil. Biosolids are contaminated by low concentrations (ng g-1 dw range) of a large variety of organic contaminants, such as triclosan (TCS). The effect of exposure to low concentrations of organic contaminants on soil biota remains largely undocumented. We evaluated the sublethal effects of TCS on the earthworm Eisenia andrei using an artificial soil amended with a nominal concentration of TCS of 50 ng g-1 dry weight soil...
April 18, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29665131/autophagy-and-its-implications-against-early-full-nutrition-support-in-critical-illness
#5
Lisa Van Dyck, Michaël P Casaer, Jan Gunst
The timing, dose, and route of early nutrition support in critically ill patients have been highly controversial for years. Despite the association of a caloric deficit with adverse outcome, several recent large, randomized, controlled trials have demonstrated a prolongation of organ failure and increased muscle weakness with increasing doses of nutrition in the acute phase of critical illness. A potential explanation for the negative impact of early, full feeding on outcome is feeding-induced suppression of autophagy, a cellular repair process that is necessary to clear intracellular damage...
April 17, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29665012/wavelet-pressure-reactivity-index-a-validation-study
#6
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Peter J Hutchinson, Xiao Hu, Peter Smielewski, Ken Brady
KEY POINTS: The brain is vulnerable to damage from too little or too much blood flow. A physiological mechanism called cerebral autoregulation (CA) exists to maintain stable blood flow even if cerebral perfusion pressure (CPP) is changing. A robust method for assessing CA is not yet available. There are still some problems with the traditional measure, the pressure reactivity index (PRx). We introduced a new method, wavelet transform method (wPRx) to assess CA using data from two sets of controlled hypotension experiments in piglets: One set with artificially manipulated ABP oscillations; the other group were spontaneous ABP waves...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29664094/analysis-of-poly-adp-ribose-polymerase-1-by-enzyme-initiated-auto-parylation-controlled-aggregation-of-hemin-graphene-nanocomposites
#7
Yong Liu, Xiaolin Xu, Haitang Yang, Ensheng Xu, Shuangshuang Wu, Wei Wei, Jin Chen
Poly(ADP-ribose) polymerase-1 (PARP-1) is a highly conserved nuclear enzyme, which binds tightly to damaged DNA and plays a key role in DNA repair, recombination, proliferation, and genomic stability. However, due to the poor electrochemical and optical activity of PARP-1 and its product PAR, only a few studies on its activity detection method have been reported. Herein, we report a simple and sensitive colorimetric strategy to monitor PARP-1 activity based on enzyme-initiated auto-PARylation-controlled aggregation of hemin-graphene nanocomposites (H-GNs)...
April 17, 2018: Analyst
https://www.readbyqxmd.com/read/29660615/biochemical-and-molecular-alterations-in-freshwater-mollusks-as-biomarkers-for-petroleum-product-domestic-heating-oil
#8
Ali Abdulhamza Al-Fanharawi, Adel M Rabaa, Ayad M J Al-Mamoori
To investigate the effect one of the oil products, domestic heating oil (DHO), on freshwater mollusks, Unio tigridis and Viviparous bengalensis were exposed to three DHO concentrations for each species (5.8, 8.7, and 17.4 ml L-1 for mussels; 6.5, 9.7, and 19.5 mlL-1 for snails, respectively). Antioxidant enzymes (superoxide dismutase, catalase), malondialdehyde, acetylcholinesterase and DNA damage in both species tissues were monitored over 21 days. The results showed that both antioxidant enzymes concentration (SOD and CAT) increased in the lowest DHO concentrations (5...
April 13, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29658050/aggregation-pheromone-of-the-bearded-weevil-rhinostomus-barbirostris-coleoptera-curculionidae-identification-synthesis-absolute-configuration-and-bioactivity
#9
Analú C Reis, Palmira L S Neta, Jéssica P Jordão, José Inácio L Moura, Diogo M Vidal, Paulo H G Zarbin, Carla F Fávaro
The bearded weevil, Rhinostomus barbirostris (Coleoptera: Curculionidae: Dryophthorinae), attacks coconut trees, oil palms and other species of Arecaceae. Besides direct damage, R. barbirostris may be a vector of diseases in coconut and oil palms, such as stem bleeding (resinosis) and red ring disease. Currently, the only method to control this weevil is by visual observation of damage and removal of infected plants. Semiochemical-based trapping could improve the effectiveness of monitoring and management of R...
April 16, 2018: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29656192/in-vitro-bioanalysis-of-drinking-water-from-source-to-tap
#10
Anna Kjerstine Rosenmai, Johan Lundqvist, Théo le Godec, Åsa Ohlsson, Rikard Tröger, Björn Hellman, Agneta Oskarsson
The presence of chemical pollutants in sources of drinking water is a key environmental problem threatening public health. Efficient removal of pollutants in drinking water treatment plants (DWTPs) is needed as well as methods for assessment of the total impact of all present chemicals on water quality. In the present study we have analyzed the bioactivity of water samples from source to tap, including effects of various water treatments in a DWTP, using a battery of cell-based bioassays, covering health-relevant endpoints...
April 6, 2018: Water Research
https://www.readbyqxmd.com/read/29656163/myofibrilar-functional-dysregulation-in-fish-a-new-biomarker-of-damage-to-pesticides
#11
Andrea C Crupkin, Fernando G Iturburu, Marcos Crupkin, Mirta L Menone
Endosulfan (ES) modifies the ultrastructure of skeletal muscle fibers and causes changes to the swimming behavior of fish. The objectives of the present work were to evaluate, in fishes of Australoheros facetus, 1) the integrity of myofibrils (Mf) by the analysis of SDS-PAGE profiles, and 2) the functionality of Mf through the microscopically monitoring of the contraction and changes in Mg2+ Ca2+ - ATPase and Mg2+ (EGTA) -ATPase activities. As expected, after the addition of the contraction buffer, control fish Mf contracted...
April 12, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29652184/dioxin-like-compounds-in-lake-fish-species-evaluation-by-dr-calux-bioassay
#12
S Sciuto, M Prearo, R Desiato, C Bulfon, E A V Burioli, G Esposito, C Guglielmetti, L Dell'atti, G Ru, D Volpatti, P L Acutis, F Martucci
Fish consumption is the principal source of intake of organochlorinated compounds in humans. Compared with other types of foods of animal origin, fish contain the highest levels of polychlorinated biphenyls (PCBs), polychlorinated dibenzo- p-dioxins, and polychlorinated dibenzofurans, all of which are classified as highly toxic organochlorine compounds. Currently, lakes and fish farms in northern Italy are not regularly monitored for PCBs and dioxins in areas contaminated by industrial sources, partially because of the high costs of traditional analytical methods that limit the number of samples to be analyzed...
April 13, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29649274/present-day-monitoring-underestimates-the-risk-of-exposure-to-pathogenic-bacteria-from-cold-water-storage-tanks
#13
Aji Peter, Edwin Routledge
Water-borne bacteria, found in cold water storage tanks, are causative agents for various human infections and diseases including Legionnaires' disease. Consequently, regular microbiological monitoring of tank water is undertaken as part of the regulatory framework used to control pathogenic bacteria. A key assumption is that a small volume of water taken from under the ball valve (where there is easy access to the stored water) will be representative of the entire tank. To test the reliability of this measure, domestic water samples taken from different locations of selected tanks in London properties between November 2015 and July 2016 were analysed for TVCs, Pseudomonas and Legionella at an accredited laboratory, according to regulatory requirements...
2018: PloS One
https://www.readbyqxmd.com/read/29628753/motorized-micro-forceps-with-active-motion-guidance-based-on-common-path-ssoct-for-epiretinal-membranectomy
#14
Gyeong Woo Cheon, Berk Gonenc, Russell H Taylor, Peter L Gehlbach, Jin U Kang
In this study, we built and tested a handheld motion-guided micro-forceps system using common-path swept source optical coherence tomography (CP-SSOCT) for highly accurate depth controlled epiretinal membranectomy. A touch sensor and two motors were used in the forceps design to minimize the inherent motion artifact while squeezing the tool handle to actuate the tool and grasp, and to independently control the depth of the tool-tip. A smart motion monitoring and a guiding algorithm were devised to provide precise and intuitive freehand control...
December 2017: IEEE/ASME Transactions on Mechatronics
https://www.readbyqxmd.com/read/29625197/a-single-subconvulsant-dose-of-domoic-acid-at-mid-gestation-does-not-cause-temporal-lobe-epilepsy-in-mice
#15
Fanny Demars, Kristen Clark, Megan S Wyeth, Emily Abrams, Paul S Buckmaster
Harmful blooms of domoic acid (DA)-producing algae are a problem in oceans worldwide. DA is a potent glutamate receptor agonist that can cause status epilepticus and in survivors, temporal lobe epilepsy. In mice, one-time low-dose in utero exposure to DA was reported to cause hippocampal damage and epileptiform activity, leading to the hypothesis that unrecognized exposure to DA from contaminated seafood in pregnant women can damage the fetal hippocampus and initiate temporal lobe epileptogenesis. However, development of epilepsy (i...
April 3, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29624855/evaluation-of-movement-behaviors-to-inform-toxic-baiting-strategies-for-invasive-wild-pigs-sus-scrofa
#16
Michael J Lavelle, Nathan P Snow, Joseph M Halseth, Eric H VanNatta, Heather N Sanders, Kurt C VerCauteren
BACKGROUND: Invasive wild pigs damage agriculture, property, and natural ecosystems. To curtail damage, an effective and humane toxic bait containing microencapsulated sodium nitrite is under development. Strategies for delivering the toxic bait are needed to establish adequate spacing of bait sites, and for simultaneously accustoming wild pigs to the novel bait and wild pig-specific bait stations designed to exclude non-target species. RESULTS: We monitored movements of 32 GPS collared wild pigs relative to 41 bait sites containing placebo bait...
April 6, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29623845/is-treat-to-target-in-lupus-nephritis-realistic-in-clinical-practice
#17
Chi Chiu Mok
The treat-to-target (T2T) principle has been advocated in a number of inflammatory and non-inflammatory medical illnesses. Tight control of disease activity has been shown to improve the outcome of rheumatoid arthritis and psoriatic arthritis as compared to the conventional approach. However, whether T2T can be applied to patients with lupus nephritis is still under hot discussion. Treatment of lupus nephritis should target at inducing and maintaining remission of the kidney inflammation so as to preserve renal function and improve survival in the long-term...
April 5, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29604176/deficits-in-prospective-memory-following-damage-to-the-medial-subdivision-of-the-mediodorsal-thalamic-nucleus
#18
Giorgia Cona, Gianvito Laera, Nicola Edelstyn, Patrizia S Bisiacchi
Identifying the neurocognitive mechanisms that lead individuals remembering to execute an intention at the right moment (prospective memory, PM) and how such mechanisms are influenced by the features of that intention is a fundamental theoretical challenge. In particular, the functional contribution of subcortical regions to PM is still unknown. This study was aimed at investigating the role of the medial subdivision of the mediodorsal thalamic nucleus (mMDT) in PM, with particular focus on the processes that are mediated by the projections from/to this structure...
March 31, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29601929/6-ohbde-47-induces-transcriptomic-alterations-of-cyp1a1-xrcc2-hspa1a-egr1-genes-and-trigger-apoptosis-in-hepg2-cells
#19
Quaiser Saquib, Maqsood A Siddiqui, Javed Ahmad, Sabiha M Ansari, Hend A Al-Wathnani, Christopher Rensing
In this study, HepG2 cells were exposed to 6-hydroxy- 2,2',4,4'-tetrabromodiphenyl ether (6-OHBDE-47) for 3 and 6 days for monitoring cytotoxic effects and alterations in its transcriptomic profile. MTT assay showed that cells exposed to 6-OHBDE-47 (50 nM) exhibited 48.5% and 53.7% decline in cell survival after 3 and 6 days. Neutral red uptake (NRU) assay also demonstrated 47.1% and 56% reduction in cell survival at 50 nM, indicating lysosomal toxicity. The flow cytometric data confirmed an increase in intracellular reactive oxygen species (ROS) and mitochondrial dysfunction (ΔYm)...
March 27, 2018: Toxicology
https://www.readbyqxmd.com/read/29595916/the-complement-system-in-hypertension-and-renal-damage-in-the-dahl-ss-rat
#20
Jean F Regal, Connor F Laule, Luke McCutcheon, Kate M Root, Hayley Lund, Shireen Hashmat, David L Mattson
Evidence indicates the immune system is important in development of hypertension and kidney disease. In the Dahl Salt-Sensitive (SS) rat model, lymphocytes play a role in development of hypertension and kidney damage after increased sodium intake. Recent transcriptomic analyses demonstrate upregulation of the innate immune complement system in the kidney of Dahl SS rat fed a high-salt diet, leading us to hypothesize that inhibition of complement activation would attenuate development of hypertension and kidney damage...
March 2018: Physiological Reports
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