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https://www.readbyqxmd.com/read/29443072/extraction-of-ramie-fiber-in-alkali-hydrogen-peroxide-system-supported-by-controlled-release-alkali-source
#1
Chaoran Meng, Zhaoling Li, Chaoyun Wang, Chongwen Yu, Xuerong Bi, Siyi Wang
This protocol demonstrates a method for ramie fiber extraction by scouring raw ramie in an alkali hydrogen peroxide system supported by a controlled-release alkali source. The fiber extracted from ramie is a type of textile material of great importance. In previous studies, ramie fiber was extracted in an alkali hydrogen peroxide system supported only by sodium hydroxide.However, due to the strong alkalinity of sodium hydroxide, the oxidation reaction speed of hydrogen peroxide was difficult to control and thus resulted in great damage to the treated fiber...
February 6, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29443023/laser-microirradiation-to-study-in-vivo-cellular-responses-to-simple-and-complex-dna-damage
#2
Xiangduo Kong, Gladys M S Cruz, Bárbara A Silva, Nicole M Wakida, Nima Khatibzadeh, Michael W Berns, Kyoko Yokomori
DNA damage induces specific signaling and repair responses in the cell, which is critical for protection of genome integrity. Laser microirradiation became a valuable experimental tool to investigate the DNA damage response (DDR) in vivo. It allows real-time high-resolution single-cell analysis of macromolecular dynamics in response to laser-induced damage confined to a submicrometer region in the cell nucleus. However, various laser conditions have been used without appreciation of differences in the types of damage induced...
January 31, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29440469/air-drop-blood-supply-in-the-french-army
#3
Olivier Javaudin, A Baillon, N Varin, C Martinaud, T Pouget, C Civadier, B Clavier, A Sailliol
BACKGROUND: Haemorrhagic shock remains the leading cause of preventable death in overseas and austere settings. Transfusion of blood components is critical in the management of this kind of injury. For French naval and ground military units, this supply often takes too long considering the short shelf-life of red blood cell concentrates (RBCs) and the limited duration of transport in cooling containers (five to six days). Air-drop supply could be an alternative to overcome these difficulties on the condition that air-drop does not cause damage to blood units...
February 12, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29436195/impact-of-ambulatory-blood-pressure-on-early-cardiac-and-renal-dysfunction-in-hypertensive-patients-without-clinically-apparent-target-organ-damage
#4
Darae Kim, Chi Young Shim, Geu Ru Hong, Sungha Park, In Jeong Cho, Hyuk Jae Chang, Jong Won Ha, Namsik Chung
PURPOSE: Impaired left ventricular (LV) global longitudinal strain (GLS) and the presence of microalbuminuria indicate early cardiac and renal dysfunction. We aimed to determine the relationships among 24-h ambulatory blood pressure (BP) variables, LV GLS, and urine albumin creatinine ratio (UACR) in hypertensive patients. MATERIALS AND METHODS: A total of 130 hypertensive patients (mean age 53 years; 59 men) underwent 24-h ambulatory BP monitoring, measurements of peripheral and central BPs, and transthoracic echocardiography...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29426697/the-prognostic-value-of-basal-dna-damage-level-in-peripheral-blood-lymphocytes-of-patients-affected-by-bladder-cancer
#5
Alessandra Allione, Barbara Pardini, Clara Viberti, Marco Oderda, Marco Allasia, Paolo Gontero, Paolo Vineis, Carlotta Sacerdote, Giuseppe Matullo
BACKGROUND: Bladder cancer (BC) is one of the most aggressive malignancies of the urinary tract, with the highest lifetime treatment costs per patient of all cancers, due to the high rate of recurrences requiring continuous surveillance. An early diagnosis is essential to improve survival of patients with BC. Noninvasive and sensitive molecular biomarkers are needed to improve current strategies for the detection and monitoring of BC. Previous studies suggested that elevated DNA damage levels and suboptimal nucleotide excision DNA repair (NER) may be associated with BC...
February 6, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29424349/therapeutic-effects-of-n-acetyl-l-cysteine-on-liver-damage-induced-by-long-term-ccl4-administration
#6
REVIEW
Oľga Otrubová, Ladislav Turecký, Oľga Uličná, Pavol Janega, Ján Luha, Jana Muchová
N-acetyl-L-cysteine (NAC) is a drug routinely used in several health problems, e.g. liver damage. There is some information emerged on its negative effects in certain situations. The aim of our study was to examine its ability to influence liver damage induced by long-term burden. We induced liver damage by CCl4 (10 weeks) and monitored the impact of parallel NAC administration (daily 150 mg/kg of b.w.) on liver morphology and some biochemical parameters (triacylglycerols, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, bile acids, proteins, albumins and cholinesterase)...
January 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29415505/in-vivo-evaluation-of-cerebral-hemodynamics-and-tissue-morphology-in-rats-during-changing-fraction-of-inspired-oxygen-based-on-spectrocolorimetric-imaging-technique
#7
Afrina Mustari, Takuya Kanie, Satoko Kawauchi, Shunichi Sato, Manabu Sato, Yasuaki Kokubo, Izumi Nishidate
During surgical treatment for cerebrovascular diseases, cortical hemodynamics are often controlled by bypass graft surgery, temporary occlusion of arteries, and surgical removal of veins. Since the brain is vulnerable to hypoxemia and ischemia, interruption of cerebral blood flow reduces the oxygen supply to tissues and induces irreversible damage to cells and tissues. Monitoring of cerebral hemodynamics and alteration of cellular structure during neurosurgery is thus crucial. Sequential recordings of red-green-blue (RGB) images of in vivo exposed rat brains were made during hyperoxia, normoxia, hypoxia, and anoxia...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29412292/practice-of-use-of-diapers-in-hospitalized-adults-and-elderly-cross-sectional-study
#8
Graziele Ribeiro Bitencourt, Luise de Almeida Ferreira Alves, Rosimere Ferreira Santana
OBJECTIVE: analyze the practice of use of diapers in adults and elderly in hospital. METHOD: observational cross-sectional study, with a sample of 105 participants assigned according to the data collection period, from September 2013 to January 2014, in the surgical clinic wards in a University Hospital. RESULTS: it was observed that 38% of the 105 participants of the study did not need the use of diapers. 18% used it because they were disabled and 16% had their cognitive system damaged...
March 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29405568/microfabricated-probes-for-studying-brain-chemistry-a-review
#9
REVIEW
Thitaphat Ngernsutivorakul, Thomas S White, Robert T Kennedy
Probe techniques for monitoring in vivo chemistry (e.g., electrochemical sensors and microdialysis sampling probes) have significantly contributed to a better understanding of neurotransmission in correlation to behaviors and neurological disorders. Microfabrication allows construction of neural probes with high reproducibility, scalability, design flexibility, and multiplexed features. This technology has translated well into fabricating miniaturized neurochemical probes for electrochemical detection and sampling...
February 5, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29402285/18f-vc701-pet-and-mri-in-the-in-vivo-neuroinflammation-assessment-of-a-mouse-model-of-multiple-sclerosis
#10
Sara Belloli, Lucia Zanotti, Valentina Murtaj, Cristina Mazzon, Giuseppe Di Grigoli, Cristina Monterisi, Valeria Masiello, Leonardo Iaccarino, Andrea Cappelli, Pietro Luigi Poliani, Letterio Salvatore Politi, Rosa Maria Moresco
BACKGROUND: Positron emission tomography (PET) using translocator protein (TSPO) ligands has been used to detect neuroinflammatory processes in neurological disorders, including multiple sclerosis (MS). The aim of this study was to evaluate neuroinflammation in a mouse MS model (EAE) using TSPO-PET with 18F-VC701, in combination with magnetic resonance imaging (MRI). METHODS: MOG35-55/CFA and pertussis toxin protocol was used to induce EAE in C57BL/6 mice. Disease progression was monitored daily, whereas MRI evaluation was performed at 1, 2, and 4 weeks post-induction...
February 5, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29401352/fibrinogen-concentrate-in-the-special-operations-forces-environment
#11
Steven Sanders, Homer Tien, Jeannie Callum, Barto Nascimento, Henry Peng, Chris Funk, Joanne Schmid, Sandro Rizoli, Shawn Rhind, Andrew Beckett
Introduction: Hemorrhage is the most common cause of death among Special Operations Force (SOF) soldiers. Bringing remote damage control resuscitation into the far-forward combat environment is logistically challenging, as it requires blood products that generally require a robust cold chain. Alternatively, lyophilized products such as fibrinogen concentrate, which does not require thawing or blood group compatibility testing before use, might be advantageous in damage control resuscitation in the battlefield...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29395641/the-burden-of-diabetes-and-the-chance-of-a-previous-stroke-thrombolysis-for-recurrent-stroke-in-diabetics
#12
Alexandra Filipov, Anne D Ebert, Eva Neumaier-Probst, Angelika Alonso
BACKGROUND: Intravenous thrombolysis with recombinant tissue plasminogen activator is still not approved by the European Medicines Agency for patients with diabetes mellitus and previous stroke. We assessed functional benefit and potential risk of thrombolysis in patients with diabetes and previous stroke and the influence of age, preexisting diabetic damage, as well as acute and chronic hyperglycemia on outcome, symptomatic intracranial hemorrhage, and in-hospital mortality. METHODS: We analyzed 527 consecutive patients treated with thrombolysis for acute stroke...
January 26, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29393689/zolpidem-efficacy-and-safety-in-disorders-of-consciousness
#13
Calixto Machado, Mario Estévez, Rafael Rodriguez-Rojas
Sutton and Clauss presented a detailed review about the effectiveness of zolpidem, discussing recoveries from brain damage due to strokes, trauma and hypoxia. A significant finding has been the unexpected and paradoxical increment of brain activity in vegetative state/unresponsive wakefulness syndrome (VS/UWS). On the contrary, zolpidem is considered one of the best sleep inducers in normal subjects. We have studied series of VS/UWS cases after zolpidem intake. We have demonstrated EEG activation, increment of BOLD signal in different brain regions, and an autonomic influence, mainly characterized by a vagolytic chronotropic effect without a significant increment of the vasomotor sympathetic tone...
February 2, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29393242/focus-on-the-involvement-of-the-nose-and-paranasal-sinuses-in-eosinophilic-granulomatosis-with-polyangiitis-churg-strauss-syndrome-nasal-cytology-reveals-infiltration-of-eosinophils-as-a-very-common-feature
#14
Veronica Seccia, Chiara Baldini, Manuela Latorre, Matteo Gelardi, Iacopo Dallan, Lodovica Cristofani-Mencacci, Stefano Sellari-Franceschini, Maria Laura Bartoli, Elena Bacci, Pierluigi Paggiaro
BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing vasculitis that predominantly affects small- to medium-sized vessels. It is characterized by a wide spectrum of extrapulmonary symptoms, including sinonasal and paranasal sinus abnormalities. These are the most common features of this disease, constituting diagnostic criteria for EGPA. However, the actual clinical features, cellular mechanisms and impact on patients' quality of life (QoL) are still a matter of study...
January 23, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29391793/ultrasound-mediated-cavitation-does-not-decrease-the-activity-of-small-molecule-antibody-or-viral-based-medicines
#15
Rachel Myers, Megan Grundy, Cliff Rowe, Christian M Coviello, Luca Bau, Philippe Erbs, Johann Foloppe, Jean-Marc Balloul, Colin Story, Constantin C Coussios, Robert Carlisle
The treatment of cancer using nanomedicines is limited by the poor penetration of these potentially powerful agents into and throughout solid tumors. Externally controlled mechanical stimuli, such as the generation of cavitation-induced microstreaming using ultrasound (US), can provide a means of improving nanomedicine delivery. Notably, it has been demonstrated that by focusing, monitoring and controlling the US exposure, delivery can be achieved without damage to surrounding tissue or vasculature. However, there is a risk that such stimuli may disrupt the structure and thereby diminish the activity of the delivered drugs, especially complex antibody and viral-based nanomedicines...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29384857/heart-rate-variability-in-normal-tension-glaucoma-a-case-control-study
#16
Natalia Ivanovna Kurysheva, Vitaliy Nikiforovich Shlapak, Tamara Yakovlevna Ryabova
Primary vascular dysregulation (PVD) is believed to be a main cause of local vasospasm and impaired autoregulation as a possible contributing factor in the pathogenesis of normal tension glaucoma (NTG). Subjects with PVD respond stronger to psychological stress. Autonomic dysfunction is another reason of instable ocular blood flow and may be studied by means of assessment of heart rate variability (HRV) especially during a hand-cold provocation test (CPT).To compare the shift of HRV parameters in NTG and healthy subjects after a cold provocation test and to assess the relation between structural damage, circulatory parameters and autonomic dysfunction in NTG...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29372366/lethal-and-sublethal-effects-of-metal-polluted-sediments-on-chironomus-sancticaroli-strixino-and-strixino-1981
#17
Frederico Guilherme de Souza Beghelli, Julio César Lopez-Dovál, André Henrique Rosa, Marcelo Pompêo, Viviane Moschini Carlos
The Cantareira Complex is one of the most important water supplies of the metropolitan region of São Paulo, Brazil. Previously, it was demonstrated that the sediments in this complex were polluted with metals and that Paiva Castro Reservoir-the last reservoir in the sequence, which receives water from the five previous reservoirs-was the reservoir with the greatest concentration of pollutants. Based on field data, it was noticed that copper concentrations in sediments were related to morphological alterations in chironomids...
January 25, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29371995/fluorescence-detection-of-cell-death-in-liver-of-mice-treated-with-thioacetamide
#18
Jin Seok Kang
The purpose of this study was to detect cell death in the liver of mice treated with thioacetamide (TAA) using fluorescence bioimaging and compare this outcome with that using conventional histopathological examination. At 6 weeks of age, 24 mice were randomly divided into three groups: group 1 (G1), control group; group 2 (G2), fluorescence probe control group; group 3 (G3), TAA-treated group. G3 mice were treated with TAA. Twenty-two hours after TAA treatment, G2 and G3 mice were treated with Annexin-Vivo 750...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29361834/the-effect-of-moderate-versus-high-intensity-resistance-training-on-systemic-redox-state-and-dna-damage-in-healthy-older-women
#19
Pedro Gargallo, Juan C Colado, Alavaro Juesas, Amaya Hernando-Espinilla, Nuria Estañ-Capell, Lidia Monzó-Beltran, Paula García-Pérez, Omar Cauli, Guillermo T Sáez
This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women. METHODS: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8-9 on the OMNI-Resistance Exercise Scale for use with elastic bands...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29358002/the-effect-of-a-natural-food-based-tube-feeding-in-minimizing-diarrhea-in-critically-ill-neurological-patients
#20
Simone B Schmidt, Willibald Kulig, Ralph Winter, Antje S Vasold, Anette E Knoll, Jens D Rollnik
BACKGROUND & AIMS: Diarrhea has negative consequences for patients, health care staff and health care costs when neurological patients are fed enterally over long periods. We examined the effect of tube feeding with natural foods in reducing the number of fluid stool evacuations and diarrhea in critically ill neurological patients. METHODS: A multicenter, prospective, open-label and randomized controlled trial (RCT) was conducted at facilities in Germany specializing in early rehabilitation after neurological damage...
January 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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