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https://www.readbyqxmd.com/read/28818116/distinct-white-matter-microstructural-abnormalities-and-extracellular-water-increases-relate-to-cognitive-impairment-in-alzheimer-s-disease-with-and-without-cerebrovascular-disease
#1
Fang Ji, Ofer Pasternak, Siwei Liu, Yng Miin Loke, Boon Linn Choo, Saima Hilal, Xin Xu, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Juan Zhou
BACKGROUND: Mixed vascular and neurodegenerative dementia, such as Alzheimer's disease (AD) with concomitant cerebrovascular disease, has emerged as the leading cause of age-related cognitive impairment. The brain white matter (WM) microstructural changes in neurodegeneration well-documented by diffusion tensor imaging (DTI) can originate from brain tissue or extracellular free water changes. The differential microstructural and free water changes in AD with and without cerebrovascular disease, especially in normal-appearing WM, remain largely unknown...
August 17, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28816833/perioperative-use-of-erythromycin-reduces-cognitive-decline-after-coronary-artery-bypass-grafting-surgery-a-pilot-study
#2
Evanthia Thomaidou, Helena Argiriadou, Georgios Vretzakis, Kalliopi Megari, Nikolaos Taskos, Georgios Chatzigeorgiou, Kyriakos Anastasiadis
OBJECTIVES: Adverse neurologic outcome can be a debilitating complication after cardiac surgery. The aim of this study was to investigate the potential neuroprotective action of erythromycin, a well known antibiotic agent, regarding postoperative cognitive decline in patients undergoing cardiac surgery. METHODS: Forty patients scheduled for elective coronary artery bypass grafting surgery were prospectively randomly assigned in 2 groups: the erythromycin group (n = 19) who received erythromycin at a dose of 25 mg/kg before and after surgery and the control group (n = 21) who did not receive it...
August 14, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28816229/plasma-expression-level-of-mirna-let-7-is-positively-correlated-with-carotid-intima-media-thickness-in-patients-with-essential-hypertension
#3
Y-Q Huang, C Huang, J-Y Chen, J Li, Y-Q Feng
MicroRNAs (miRNA, miR) play vital part in the pathophysiology of arterial remodeling in hypertension patients, and are increasingly becoming novel biomarkers in cardiovascular disease. The study was designed to evaluate the correlation between let-7 expression level and subclinical atherosclerosis in untreated patients with newly diagnosed essential hypertension. We assessed 240 participants including 60 healthy volunteers with normal carotid intima-media thickness (nCIMT), 60 healthy volunteers with increased CIMT (iCIMT), 60 hypertension patients with nCIMT and 60 hypertension patients with iCIMT...
August 17, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28810961/resuscitation-of-hypotensive-traumatic-brain-injured-animals-with-spray-dried-plasma-does-not-adversely-alter-physiology-and-improves-blood-brain-barrier-function
#4
Steven McDaniel, Stephanie Golla, Anthony N Moore, Joe DaCorta, Arthur Bode, Shibani Pati, Pramod K Dash, Jing Zhao
INTRODUCTION: According to the Defense and Veterans Brain Injury Center and the Armed Forces Health Surveillance Center, the number of soldiers who have sustained a traumatic brain injury (TBI) has risen dramatically over the past decade. Studies have shown that brain damage can be exacerbated if blood loss occurs (often occurring in polytrauma). As blood supply is critical for brain function and survival, TBI patients must be properly resuscitated to maintain blood volume, blood pressure, and cerebral perfusion...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28804814/factors-associated-with-cardiovascular-target-organ-damage-in-children-after-renal-transplantation
#5
Bianca Borchert-Mörlins, Daniela Thurn, Bernhard M W Schmidt, Anja K Büscher, Jun Oh, Tanja Kier, Elena Bauer, Sabrina Baig, Nele Kanzelmeyer, Markus J Kemper, Rainer Büscher, Anette Melk
BACKGROUND: Cardiovascular disease is the second-most common cause of death in pediatric renal transplant recipients. The aim of this study was to evaluate subclinical cardiovascular target organ damage defined as the presence of arterio- and atherosclerotic lesions and cardiac remodeling and to analyze contributing risk factors in a large cohort of children after renal transplantation (RT). METHODS: A total of 109 children aged 13.1 ± 3.3 years who had undergone RT at one of three German transplant centers were enrolled in this study...
August 13, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28792613/peripheral-perfusion-and-oxygenation-in-areas-of-risk-of-skin-integrity-impairment-exposed-to-pressure-patterns-a-phase-i-trial-poter-study
#6
Silvia Garcia-Mayor, Juan Carlos Morilla-Herrera, Inmaculada Lupiáñez-Pérez, Shakira Kaknani Uttumchandani, Álvaro Leon Campos, Marta Aranda-Gallardo, Ana Belén Moya-Suárez, José Miguel Morales-Asencio
AIM: To analyse the changes in peripheral oxygenation and microvascular flow in tissues subjected to different pressure regimes in healthy subjects and in hospitalised patients. BACKGROUND: The presence of pressure ulcers in hospitalised patients is a common complication that has a negative impact on health and often prolongs hospital stay and increases health care costs. DESIGN: Experimental non-controlled, non-randomised study in two phases: preclinical and clinical...
August 9, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28791975/comparison-of-ckd-epi-versus-mdrd-and-cockcroft-gault-equations-to-estimate-glomerular-filtration-rate-among-stable-homozygous-sickle-cell-patients-in-southwest-nigeria
#7
C L Uche, I D Osegbe
BACKGROUND: Homozygous sickle cell patients are prone to renal damage which can be on-going in and out of crises, therefore, there is a need to monitor renal status using glomerular filtration rate. Equations to estimate GFR are readily available. Cockcroft-Gault equation is widely used, while the MDRD formula is the currently accepted equation. The CKD-EPI equation is recently being recommended but has not been validated among HbSS patients. Therefore, we aim to compare estimated GFR using CKD-EPI versus MDRD and Cockcroft-Gault equations among HbSS patients...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28783096/c-di-amp-an-essential-molecule-in-the-signaling-pathways-that-regulate-the-viability-and-virulence-of-gram-positive-bacteria
#8
REVIEW
Tazin Fahmi, Gary C Port, Kyu Hong Cho
Signal transduction pathways enable organisms to monitor their external environment and adjust gene regulation to appropriately modify their cellular processes. Second messenger nucleotides including cyclic adenosine monophosphate (c-AMP), cyclic guanosine monophosphate (c-GMP), cyclic di-guanosine monophosphate (c-di-GMP), and cyclic di-adenosine monophosphate (c-di-AMP) play key roles in many signal transduction pathways used by prokaryotes and/or eukaryotes. Among the various second messenger nucleotides molecules, c-di-AMP was discovered recently and has since been shown to be involved in cell growth, survival, and regulation of virulence, primarily within Gram-positive bacteria...
August 7, 2017: Genes
https://www.readbyqxmd.com/read/28780627/primary-pediatric-hypertension-current-understanding-and-emerging-concepts
#9
REVIEW
Andrew C Tiu, Michael D Bishop, Laureano D Asico, Pedro A Jose, Van Anthony M Villar
The rising prevalence of primary pediatric hypertension and its tracking into adult hypertension point to the importance of determining its pathogenesis to gain insights into its current and emerging management. Considering that the intricate control of BP is governed by a myriad of anatomical, molecular biological, biochemical, and physiological systems, multiple genes are likely to influence an individual's BP and susceptibility to develop hypertension. The long-term regulation of BP rests on renal and non-renal mechanisms...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28780562/rationale-and-design-of-a-multicentre-prospective-randomised-controlled-clinical-trial-to-evaluate-the-efficacy-of-the-adipose-graft-transposition-procedure-in-patients-with-a-myocardial-scar-the-agtp-ii-trial
#10
Paloma Gastelurrutia, Carolina Gálvez-Montón, Maria Luisa Cámara, Juan Bustamante-Munguira, Pablo García-Pavia, Pablo Avanzas, J Alberto San Román, Domingo Pascual-Figal, Eduardo de Teresa, Maria G Crespo-Leiro, Nicolás Manito, Julio Núñez, Francisco Fernández-Avilés, Ángel Caballero, Albert Teis, Josep Lupón, Ramón Brugada, Carlos Martín, Jacobo Silva, Ana Revilla-Orodea, Sergio J Cánovas, Jose M Melero, Jose J Cuenca-Castillo, Angel Gonzalez-Pinto, Antoni Bayes-Genis
INTRODUCTION: Cardiac adipose tissue is a source of progenitor cells with regenerative capacity. Studies in rodents demonstrated that the intramyocardial delivery of cells derived from this tissue improves cardiac function after myocardial infarction (MI). We developed a new reparative approach for damaged myocardium that integrates the regenerative properties of cardiac adipose tissue with tissue engineering. In the adipose graft transposition procedure (AGTP), we dissect a vascularised flap of autologous pericardial adipose tissue and position it over the myocardial scarred area...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28775003/interference-with-gs%C3%AE-coupled-receptor-signaling-in-renin-producing-cells-leads-to-renal-endothelial-damage
#11
Peter Lachmann, Linda Hickmann, Anne Steglich, Moath Al-Mekhlafi, Michael Gerlach, Niels Jetschin, Steffen Jahn, Brigitte Hamann, Monika Wnuk, Kirsten Madsen, Valentin Djonov, Min Chen, Lee S Weinstein, Bernd Hohenstein, Christian P M Hugo, Vladimir T Todorov
Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate this possibility, we generated mice with inducible knockout of Gsα in JG cells and monitored them for 6 months after induction at 6 weeks of age. The knockout mapped exclusively to the JG cells of the Gsα-deficient animals. Progressive albuminuria occurred in Gsα-deficient mice...
August 3, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28767178/chemokine-receptor-7-ccr7-deficiency-leads-to-delayed-development-of-joint-damage-and-functional-deficits-in-a-murine-model-of-osteoarthritis
#12
Nisha Sambamurthy, Vu Nguyen, Ryan Smalley, Rui Xiao, Kurt Hankenson, Justin Gan, Rachel E Miller, Anne-Marie Malfait, George R Dodge, Carla R Scanzello
Elevated chemokine receptor Ccr7 is observed in knee osteoarthritis (OA) and associated with severity of symptoms. In this study, we confirmed that CCR7 protein expression is elevated in synovial tissue from OA patients by immunohistochemical staining. We then investigated whether Ccr7 deficiency impacted structural and functional joint degeneration utilizing a murine model of OA. OA-like disease was induced in male C57BL/6 and Ccr7-deficient (Ccr7(-/-) ) mice by destabilization of the medial meniscus (DMM)...
August 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28762916/-predictors-of-electrical-myocardial-instability-in-men-with-arterial-hypertension-and-obstructive-sleep-apnea-hypopnea-syndrome
#13
O V Lyshova, N V Borodin, I I Kostenko
OBJECTIVE: To access the detectability of corrected QT interval (QTc) prolongation ( more or equal 450 ms) and increased QT dispersion (QTd more or equal 60 ms) in men with obstructive sleep apnea-hypopnea syndrome (OSAS) and newly diagnosed arterial hypertension (AH). MATERIAL AND METHODS: We included in this study 138 men (mean age 40.5+/-6.9 years, body mass index 34.5+/-4.7 kg/m2, all with more or equal 3 risk factors of AH development, 34% with subclinical target organs damage)...
May 2017: Kardiologiia
https://www.readbyqxmd.com/read/28758299/host-modulation-controlling-the-inflammation-to-control-the-infection
#14
REVIEW
P Mark Bartold, Thomas E Van Dyke
Historically, periodontal disease (gingivitis and periodontitis) has been recognized as being primarily of bacterial origin. However, recent evidence indicates that while bacteria are necessary for disease development they are not sufficient for the clinical manifestation of the many and varied forms of periodontal disease. It is becoming increasingly apparent that it is the host inflammatory response to the subgingival bacteria that is responsible for the tissue damage and, most likely, progression of the disease...
October 2017: Periodontology 2000
https://www.readbyqxmd.com/read/28757939/correlation-between-parodontal-indexes-and-orthodontic-retainers-prospective-study-in-a-group-of-16-patients
#15
D DI Venere, F Pettini, G M Nardi, A Laforgia, G Stefanachi, V Notaro, B Rapone, F R Grassi, M Corsalini
PURPOSE: Fixed retainers are used to stabilize dental elements after orthodontic treatment. Being it a permanent treatment, it is necessary to instruct patients about a constant and continuous monitoring of their periodontal conditions and a correct oral hygiene. The aim of this study was to highlight the possible adverse effects of bonded retainers on parameters correlated to the health conditions of periodontal tissues. MATERIALS AND METHODS: We selected 16 patients, under treatment in the Orthodontics Department of University of Bari Dental School, who had undergone a lingual retainer insertion at the end of the orthodontic treatment...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28757906/lumbosacral-dorsal-rhizotomy-for-spastic-cerebral-palsy-a-health-technology-assessment
#16
(no author information available yet)
BACKGROUND: Cerebral palsy, a spectrum of neuromuscular conditions caused by abnormal brain development or early damage to the brain, is the most common cause of childhood physical disability. Lumbosacral dorsal rhizotomy is a neurosurgical procedure that permanently decreases spasticity and is always followed by physical therapy. The objectives of this health technology assessment were to evaluate the clinical effectiveness, safety, cost effectiveness, and family perspectives of dorsal rhizotomy...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28749774/assessment-of-risk-of-cholera-in-haiti-following-hurricane-matthew
#17
Rakib Khan, Rifat Anwar, Shafqat Akanda, Michael D McDonald, Anwar Huq, Antarpreet Jutla, Rita Colwell
Damage to the inferior and fragile water and sanitation infrastructure of Haiti after Hurricane Matthew has created an urgent public health emergency in terms of likelihood of cholera occurring in the human population. Using satellite-derived data on precipitation, gridded air temperature, and hurricane path and with information on water and sanitation (WASH) infrastructure, we tracked changing environmental conditions conducive for growth of pathogenic vibrios. Based on these data, we predicted and validated the likelihood of cholera cases occurring past hurricane...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28746411/selection-and-validation-of-reference-genes-for-quantitative-real-time-pcr-analysis-under-different-experimental-conditions-in-the-leafminer-liriomyza-trifolii-diptera-agromyzidae
#18
Ya-Wen Chang, Jing-Yun Chen, Ming-Xing Lu, Yuan Gao, Zi-Hua Tian, Wei-Rong Gong, Wei Zhu, Yu-Zhou Du
Liriomyza trifolii is a highly-invasive leafmining insect that causes significant damage to vegetables and horticultural crops worldwide. Relatively few studies have quantified gene expression in L. trifolii using real-time quantitative PCR (RT-qPCR), which is a reliable and sensitive technique for measuring gene expression. RT-qPCR requires the selection of reference genes to normalize gene expression data and control for internal differences between samples. In this study, nine housekeeping genes from L. trifolii were selected for their suitability in normalizing gene expression using geNorm, Normfinder, BestKeeper, the ΔCt method and RefFinder...
2017: PloS One
https://www.readbyqxmd.com/read/28741137/protection-of-the-proximal-articular-cartilage-during-percutaneous-thermal-ablation-of-acetabular-metastasis-using-temperature-monitoring
#19
Salem Bauones, Julien Garnon, Basavaraj Chari, Roberto L Cazzato, Georgia Tsoumakidou, Jean Caudrelier, Guillaume Koch, Afshin Gangi
OBJECTIVE: To review our initial experience in acetabular cartilage protection from thermal injury with temperature monitoring during percutaneous image-guided tumor thermal ablation. MATERIALS AND METHODS: Between June 2015 and December 2016, three consecutive oncologic patients (mean age 58 years; range 48-67 years) with acetabular bone metastasis underwent percutaneous image-guided thermal ablation procedures along with hip joint cartilage thermal monitoring...
July 24, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28740326/on-line-laser-radiation-controlled-to-the-removal-of-adhesive-on-teeth-after-bracket-debonding
#20
Clara Gómez, Juan Carlos Palma, Ángel Costela
BACKGROUND AND AIMS: After bracket debonding a correct removal of the adhesive from tooth surfaces without causing any iatrogenic damage to the enamel is needed. However, conventional techniques do not allow a selective removal process. The present article focuses on the removal of adhesive on teeth after bracket debonding by using laser radiation at 355 nm (third harmonic wavelength of a Q-switched Nd:YAG). MATERIAL AND METHODS: Brackets were bonded to 10 extracted human premolars from young patients and removed after a storage period of 2 months...
March 31, 2017: Laser Therapy
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