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https://www.readbyqxmd.com/read/29475131/factors-affecting-premature-plantarflexor-muscle-activity-during-hemiparetic-gait
#1
Kazuki Fujita, Hiroichi Miaki, Akira Fujimoto, Hideaki Hori, Hitomi Fujimoto, Yasutaka Kobayashi
In hemiparetic stroke survivors, premature plantarflexor muscle activity (PPF) often appears as a gait abnormality from terminal swing to the loading response on the paretic side. This study aimed to discern factors giving rise to PPF. Lower extremity function, spasticity magnitude, and gait electromyograms were assessed in 31 hemiparetic stroke survivors. Mean amplitudes during gait phases were determined for the paretic soleus, tibialis anterior, rectus femoris, and biceps femoris. The subjects were classified into PPF and non-PPF groups based on their relative soleus amplitude at different phases of gait, and group differences in each measurement were calculated and subjected to logistic regression...
February 14, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29475098/xq-1h-protects-against-ischemic-stroke-by-regulating-microglia-polarization-through-ppar%C3%AE-pathway-in-mice
#2
Rui Liu, Junjian Diao, Shucheng He, Binbin Li, Yuxiang Fei, Yunman Li, Weirong Fang
Cerebral ischemic and reperfusion injury often accompany with inflammation, and lead to severe neuronal damage, which further result in neurological disorders and memory disorders. In this study, we researched XQ-1H, a novel derivative of ginkgolide B, protecting against ischemic stroke in mice through regulation of microglia polarization. Middle cerebral artery occlusion (MCAO)/reperfusion in mice is applied to mimic ischemic stroke in vivo. Immediately after MCAO, mice are intragastric administrated with different dose (31 or 62 mg/kg) of XQ-1H for one or continuative three days...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475081/evaluation-of-neurosensory-disturbances-of-the-inferior-alveolar-nerve-after-intraoral-verticosagittal-ramus-osteotomy
#3
L A R Righesso, L F Gil, D S M C Pantoja, C Marin, R Granato, J N Gil
PURPOSE: To assess the incidence of Neurosensory Disturbances (NSD) of the Inferior Alveolar Nerve (IAN) after Intraoral Verticosagittal Ramus Osteotomy (IVSRO). MATERIALS AND METHODS: The sensibility of the chin and lower lip of ten consecutive patients undergoing IVSRO was assessed. Evaluations were performed at 7 days preoperatively, 7 days, one month and six months postoperatively. The chin was divided into four quadrants, which were tested separately. The tests used were: two-point discrimination (2-P), brush stroke direction discrimination (BSD) and thermal stimuli (TH)...
February 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29474995/evaluation-of-performance-based-outcome-measures-for-the-upper-limb-a-comprehensive-narrative-review
#4
REVIEW
Sophie Wang, Janice Hsu, Lauren Trent, Tiffany Ryan, Nathan Kearns, Eugene Civillico, Kimberly Kontson
Objective performance-based outcome measures (OMs) have the potential to provide unbiased and reproducible assessments of limb function. However, very few of these performance-based OMs have been validated for upper limb (UL) prosthesis users. OMs validated in other clinical populations (e.g. neurological or musculoskeletal conditions) could be used to fill gaps in existing performance-based OMs for UL amputees. Additionally, a joint review might reveal consistent gaps across multiple clinical populations. Therefore, the objective of this review was to systematically characterize prominent measures utilized in both sets of clinical populations with regard to (1) location of task performance around the body, (2) possible grips employed, (3) bilateral vs...
February 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29474816/coffee-for-cardioprotection-and-longevity
#5
REVIEW
James H O'Keefe, James J DiNicolantonio, Carl J Lavie
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee's effects on arrhythmias and hypertension are neutral...
February 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29474699/rationale-and-design-of-the-eacvi-afib-echo-europe-registry-for-assessing-relationships-of-echocardiographic-parameters-with-clinical-thrombo-embolic-and-bleeding-risk-profile-in-non-valvular-atrial-fibrillation
#6
Maurizio Galderisi, Erwan Donal, Julien Magne, Francesco Lo Iudice, Eustachio Agricola, Leyla Elif Sade, Matteo Cameli, Ehud Schwammenthal, Nuno Cardim, Bernard Cosyns, Andreas Hagendorff, Alexandar N Neskovic, Josè Luis Zamorano, Patrizio Lancellotti, Gilbert Habib, Thor Edvardsen, Bogdan A Popescu
The European Society of Cardiology (ESC) guidelines for management of atrial fibrillation (AF) recommend the use of CHA2DS2VASc risk score for assessment of thromboembolic (TE) risk, whereas the stratification of bleeding risk should be obtained by HAS-Bleed to balance the most appropriate anticoagulation (OAC) therapy. However, men with CHA2DS2VASc score = 1 and women with CHA2DS2VASc = 2, who are at intermediate TE risk, represent a grey zone where guidelines do not provide a definite OAC indication...
March 1, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29474482/prevalence-of-several-somatic-diseases-depends-on-the-presence-and-severity-of-obstructive-sleep-apnea
#7
Ragnhild L Tveit, Sverre Lehmann, Bjørn Bjorvatn
STUDY OBJECTIVES: The objective was to investigate the prevalence of heart attack, angina pectoris, stroke, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, asthma and obesity in relation to the presence and severity of obstructive sleep apnea. METHODS: The sample consisted of 1887 patients, with mean age of 48.6 years (range 16-83 years), referred to a university hospital on suspicion of obstructive sleep apnea. The patients filled out a questionnaire asking whether they were previously diagnosed with the comorbidities in interest...
2018: PloS One
https://www.readbyqxmd.com/read/29474453/detection-of-mitochondrial-dna-with-4977-bp-deletion-in-leukocytes-of-patients-with-ischemic-stroke
#8
Yu-Hua Huang, Chiung-Mei Chen, Yun-Shien Lee, Kuo-Hsuan Chang, Huei-Wen Chen, Yi-Chun Chen
BACKGROUND: Coronary artery disease is associated with a common mitochondrial DNA alteration, a 4977 bp deletion (mtDNA4977). The role of mtDNA4977 in ischemic stroke is unknown. METHODS: Real-time quantitative PCR was performed to quantify total mtDNA and mtDNA4977 in leukocytes in 283 ischemic stroke cases and 135 controls. Ratios of mtDNA4977 to total-mtDNA and total-mtDNA to nuclear-DNA were calculated. Nested PCR and Sanger sequencing were used to confirm undetectable levels of mtDNA4977...
2018: PloS One
https://www.readbyqxmd.com/read/29474391/support-service-utilization-and-out-of-pocket-payments-for-health-services-in-a-population-based-sample-of-adults-with-neurological-conditions
#9
Adebimpe O Obembe, Charlie H Goldsmith, Lisa A Simpson, Brodie M Sakakibara, Janice J Eng
BACKGROUND: Social support can help to deal with the consequences of neurological conditions and promote functional independence and quality of life. Our aim was to evaluate the impact of neurological conditions on the use of support and health-care services in a population-based sample of community-dwelling adults with neurological conditions. METHODS: Data were from the Survey of Living with Neurological Conditions in Canada, which was derived from a representative sample of household residents...
2018: PloS One
https://www.readbyqxmd.com/read/29474205/perioperative-management-of-a-patient-with-glanzmann-thrombasthenia-undergoing-a-coronary-artery-bypass-graft-surgery-a-case-report
#10
Mohamad Kurdi, Corinne Frère, Julien Amour, Caren Brumpt, Josée Delort, Guillaume Lebreton, Laure Croisille, Roseline d'Oiron, Isabelle Martin-Toutain
: We report herein the successful perioperative management of a 57-year-old man with a type I Glanzmann thrombasthenia undergoing coronary artery bypass graft surgery and right carotid endarterectomy. The patient suffered from several lesions in the three major coronary arteries and in the right carotid necessitating surgery. Prophylactic human leukocyte antigen (HLA)-matched platelets transfusions were continuous administrated before, and through the immediate perioperative period. Posttransfusion platelet recovery was monitored using flow cytometry to determine the percentage of circulating platelet expressing CD61 (β3)...
February 22, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29474174/the-economic-costs-of-cardiovascular-disease-diabetes-mellitus-and-associated-complications-in-south-asia-a-systematic-review
#11
REVIEW
Ian F Walker, Fredrike Garbe, Judy Wright, Ian Newell, Naveen Athiraman, Nida Khan, Helen Elsey
BACKGROUND: More than 80% of global deaths caused by cardiovascular disease (CVD) and diabetes mellitus (DM) occur in developing countries. The burden of noncommunicable disease in South Asia is increasing rapidly. OBJECTIVES: To estimate the costs of CVD and the costs of DM to individuals and society in Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka. METHODS: We systematically searched six health and economic databases for studies identifying costs related to CVD or DM and their respective complications...
July 3, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29474129/reliability-validity-and-minimal-detectable-change-of-the-mini-bestest-in-greek-participants-with-chronic-stroke
#12
Sofia I Lampropoulou, Evdokia Billis, Ingrid A Gedikoglou, Christina Michailidou, Alexander V Nowicky, Dimitra Skrinou, Fotini Michailidi, Danae Chandrinou, Margarita Meligoni
OBJECTIVES: This study aimed to investigate the psychometric characteristics of reliability, validity and ability to detect change of a newly developed balance assessment tool, the Mini-BESTest, in Greek patients with stroke. DESIGN: A prospective, observational design study with test-retest measures was conducted. METHODS: A convenience sample of 21 Greek patients with chronic stroke (14 male, 7 female; age of 63 ± 16 years) was recruited...
February 23, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29473778/assessment-of-the-praxis-circuit-in-glioma-surgery-to-reduce-the-incidence-of-postoperative-and-long-term-apraxia-a-new-intraoperative-test
#13
Marco Rossi, Luca Fornia, Guglielmo Puglisi, Antonella Leonetti, Gianmarco Zuccon, Enrica Fava, Daniela Milani, Alessandra Casarotti, Marco Riva, Federico Pessina, Gabriella Cerri, Lorenzo Bello
OBJECTIVE Apraxia is a cognitive-motor deficit affecting the execution of skilled movements, termed praxis gestures, in the absence of primary sensory or motor disorders. In patients affected by stroke, apraxia is associated with lesions of the lateral parietofrontal stream, connecting the posterior parietal areas with the ventrolateral premotor area and subserving sensory-motor integration for the hand movements. In the neurosurgical literature to date, there are few reports regarding the incidence of apraxia after glioma surgery...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29473531/diabetic-complications-and-insight-into-antidiabetic-potentialities-of-ethno-medicinal-plants-a-review
#14
Muhammad Bilal, Muhammad Sarfaraz Iqbal, Syed Bilal Shah, Tahir Rasheed, Hafiz M N Iqbal
BACKGROUND: The naturally inspired treatment options for several disease conditions and human-health related disorders such as diabetes mellitus have gained considerable research interest. In this context, naturally occurring plants and herbs with medicinal functionalities have gained special place than ever before in the current medicinal world. OBJECTIVE: The objective of this review is to extend the current knowledge in the clinical field related to the diabetic complications...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29473512/the-role-of-inflammatory-response-in-stroke-associated-programmed-cell-death
#15
K Duris, Z Splichal, M Jurajda
Stroke represents devastating pathology which is associated with a high morbidity and mortality. Initial damage caused directly by the onset of stroke, primary injury, may be eclipsed by secondary injury which may have a much more devastating effect on the brain. Primary injury is predominantly associated with necrotic cell death due to fatal insufficiency of oxygen and glucose. Secondary injury may on the contrary, lead apoptotic cell death due to structural damage which is not compatible with cellular functions or which may even represent the danger of malign transformation...
February 22, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29473480/dual-task-training-effects-on-motor-and-cognitive-functional-abilities-in-individuals-with-stroke-a-systematic-review
#16
Ying He, Lei Yang, Jing Zhou, Liqing Yao, Marco Yiu Chung Pang
OBJECTIVE: This systematic review aimed to examine the effects of dual-task balance and mobility training in people with stroke. METHODS: An extensive electronic databases literature search was conducted using MEDLINE, PubMed, EBSCO, The Cochrane Library, Web of Science, SCOPUS, and Wiley Online Library. Randomized controlled studies that assessed the effects of dual-task training in stroke patients were included for the review (last search in December 2017). The methodological quality was evaluated using the Cochrane Collaboration recommendation, and level of evidence was determined according to the criteria described by the Oxford Center for Evidence-Based Medicine...
February 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29473479/distinguishing-statistical-and-clinical-significance-in-meta-analysis-comment-on-the-effectiveness-of-hydrokinesiotherapy-on-postural-balance-of-hemiplegic-patients-after-stroke-a-systematic-review-and-meta-analysis-by-iatridou-g-et-al
#17
https://www.readbyqxmd.com/read/29473463/markers-of-neutrophil-extracellular-traps-are-associated-with-adverse-clinical-outcome-in-stable-coronary-artery-disease
#18
Miriam Sjåstad Langseth, Trine Baur Opstad, Vibeke Bratseth, Svein Solheim, Harald Arnesen, Alf Åge Pettersen, Ingebjørg Seljeflot, Ragnhild Helseth
Background Neutrophil extracellular traps, comprising chromatin and granule proteins, have been implicated in atherothrombosis. Design and methods We investigated whether the circulating neutrophil extracellular traps markers, double-stranded DNA and myeloperoxidase-DNA were associated with clinical outcome and hypercoagulability in patients with stable coronary artery disease. Patients with angiographically verified stable coronary artery disease ( n = 1001) were included. Follow-up was 2 years, recording 106 clinical endpoints (unstable angina, non-haemorrhagic stroke, myocardial infarction or death)...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29473456/peripheral-somatosensory-stimulation-and-postural-recovery-after-stroke-a-systematic-review
#19
Jonas Schröder, Steven Truijen, Tamaya Van Criekinge, Wim Saeys
Purpose It is hypothesized that peripheral somatosensory stimulation (PSS) can promote postural recovery after stroke by increasing afferent input and postural contribution of the paretic leg. Therefore, this systematic review aims to investigate which PSS approaches are documented and investigated on effectiveness. Methods Five databases (PubMed, Web of Science, PEDro, Cochrane Library Trials, RehabData) have been searched on clinical studies in stroke rehabilitation, investigating PSS, which is defined as a non-motor and focal stimulation to the paretic leg aiming an increase in somatosensory input...
February 23, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29473447/u0126-protects-hippocampal-ca1-neurons-against-forebrain-ischemia-induced-apoptosis-via-the-erk1-2-signaling-pathway-and-nmda-receptors
#20
Jianguo Li, Deping Yan, Xiaoyan Liu, Ye Wang, Xin Zhao, Yu Zhang, Ce Zhang
OBJECTIVE: Cerebral ischemia can trigger the ERK1/2 signaling cascade that enables the brain to adapt to ischemic injury. However, the mechanism of ERK1/2 in ischemic brain injury remains unclear. The aim of this study was to examine the roles of the ERK1/2 signaling pathway and NMDA receptors in the apoptosis of CA1 pyramidal neurons after ischemia/reperfusion (I/R). METHODS: Male Wistar rats were subjected to a sham or transient forebrain ischemia procedure. Animals received the intracerebroventricular injection of U0126 (5 μl, 0...
February 23, 2018: Neurological Research
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