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https://www.readbyqxmd.com/read/29785115/management-and-outcomes-of-pregnancy-with-or-without-lupus-nephritis-a-systematic-review-and-meta-analysis
#1
REVIEW
Jiayue Wu, Jinghang Ma, Wei-Hong Zhang, Wen Di
Background: Although it is well established that systemic lupus erythematosus (SLE) negatively affects pregnancy outcomes, there is insufficient evidence on the effect of lupus nephritis (LN) on antenatal management and pregnancy outcomes. We performed a systematic review and meta-analysis to determine the association of LN with management and pregnancy outcomes in SLE patients. Methods: Embase, Medline, Cochrane, and ClinicalTrials.gov were carefully searched for relevant English and Chinese language studies...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29783266/multiorgan-failure-syndrome-in-newborns-role-of-social-and-anatomico-functional-features-literature-review
#2
Dmytro A Skurupii, Evgeniy G Sonnyk, Vitaliy M Sizonenko
Protection of maternal health as well as protection of fetal and newborn health is a strategic objective in all countries. It ensures the formation of healthy generation as the basis of gene pool preservation and further development of the nation. It is known that the progress of critical conditions in newborns is different from classical concepts. Аnatomicofunctional features of the newborns (especially premature newborns), the effect of prenatal pathological factors are provocative and background factors of the multiorgan failure syndrome begining in these patients, which probably affects frequency of appearance of this syndrome, the mechanisms of development, clinical manifestations, the final of the disease and makes doctors to consider newborns in critical conditions as high-risk group for multiorgan failure syndrome appearance...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29779467/calcium-sodium-and-trp-channel-expression-in-human-fetal-midbrain-derived-neural-progenitor-cells
#3
Nancy Stanslowsky, Salini Tharmarasa, Selma Staege, Norman Kalmbach, Martin Klietz, Sigrid Schwarz, Andreas Leffler, Florian Wegner
Voltage-gated sodium and calcium channels as well as transient receptor potential (TRP) channels are expressed during the differentiation of human neural progenitor cells (hNPCs) and are likely to be involved in regulating neurogenesis. However, the molecular composition of these ion channels in proliferating and differentiating hNPCs is largely unknown. Here, we investigated fetal mesencephalic hNPCs in respect to their sodium, calcium, and TRP channel subunit expression and function. Quantitative real-time PCR indicated a significant upregulation of voltage-gated sodium and calcium channel subunits in hNPCs after differentiation for 3 weeks in vitro...
May 19, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29778368/oral-dydrogesterone-for-luteal-phase-support-in-fresh-in-vitro-fertilization-cycles-a-new-standard
#4
REVIEW
Georg Griesinger, Christophe Blockeel, Herman Tournaye
Oral dydrogesterone has been used for luteal phase support on an empirical basis since the early days of in vitro fertilization (IVF) treatment. Systematic comparisons of oral dydrogesterone with vaginal progesterone, so far considered to be the standard of care, started to appear in the middle 2000s. Recently, a large, randomized, double-blind, double-dummy phase III trial on the use of daily 30 mg oral dydrogesterone versus daily 600 mg micronized vaginal progesterone for LPS in IVF was published. This company-sponsored trial confirmed the efficacy findings from previous independent researchers and firmly established the noninferiority of daily 30 mg oral dydrogesterone for luteal phase support...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29775476/maternal-asthma-is-associated-with-increased-risk-of-perinatal-mortality
#5
Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen
BACKGROUND: Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. OBJECTIVES: Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. METHODS: The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93...
2018: PloS One
https://www.readbyqxmd.com/read/29775414/venoarterial-communication-mediates-arterial-wall-shear-stress-induced-maternal-uterine-vascular-remodeling-during-pregnancy
#6
Nga Ling Ko, Liam John, Aaron Gelinne, Maurizio Mandala, George Osol
Although expansive remodeling of the maternal uterine circulation during pregnancy is essential for maintaining uteroplacental perfusion and normal fetal growth, the underlying physiological mechanisms are not well understood. Using a rat model, surgical approaches were used to alter uterine hemodynamics and wall shear stress (WSS) in order to evaluate the effects of WSS and venoarterial communication (e.g. transfer of placentally derived growth signals from post-placental veins to pre-placental arteries) on gestational uterine vascular remodeling...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29775039/update-on-neonatal-cardiopulmonary-resuscitation
#7
(no author information available yet)
An update of the national recommendations on neonatal resuscitation elaborated by the Neonatal Resuscitation Work Area of the Fetal-Neonatal Studies Committee (CEFEN) of the Argentine Society of Pediatrics (SAP) is presented. These recommendations are original and in their elaboration, we have taken into account the best available evidence gathered by the International Liaison Committee on Resuscitation (ILCOR) as well as an exhaustive review of publications and discussions in the area to define controversial issues...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29774532/the-fetus-at-the-tipping-point-modifying-the-outcome-of-fetal-asphyxia
#8
Simerdeep K Dhillon, Christopher A Lear, Robert Galinsky, Guido Wassink, Joanne O Davidson, Sandra Juul, Nicola J Robertson, Alistair J Gunn, Laura Bennet
Brain injury around birth is associated with nearly half of all cases of cerebral palsy. Although brain injury is multifactorial, particularly after preterm birth, acute hypoxia-ischaemia is a major contributor to injury. It is now well established that the severity of injury after HI is determined by a dynamic balance between injurious and protective processes. In addition, mothers who are at risk of premature delivery have high rates of diabetes and antepartum infection/inflammation and are almost universally given treatments such as antenatal glucocorticoids and magnesium sulphate to reduce the risk of death and complications after preterm birth...
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29774380/-thyroid-and-pregnancy
#9
REVIEW
K A Iwen, H Lehnert
During pregnancy thyroid hormones have profound effects on embryonal/fetal development and maternal health. Therefore, thyroid gland disorders should be immediately diagnosed and adequately treated. Pregnancy-specific physiological alterations during pregnancy cause changes in the reference interval for thyroid-stimulating hormone levels and trimester-specific thresholds must be taken into account. This article summarizes the most important diagnostic and therapeutic aspects before, during and after pregnancy...
May 17, 2018: Der Internist
https://www.readbyqxmd.com/read/29772083/effects-of-prenatal-stress-on-anxiety-and-depressive-like-behaviors-are-sex-specific-in-prepubertal-rats
#10
Ann Mary Iturra-Mena, Marcia Arriagada-Solimano, Ariane Luttecke-Anders, Alexies Dagnino-Subiabre
The fetal brain is highly susceptible to stress in late pregnancy, with lifelong effects of stress on physiology and behavior. The aim of this study was to determine the physiological and behavioral effects of prenatal stress during the prepubertal period of female and male rats. We subjected pregnant Sprague-Dawley rats to a restraint stress protocol from gestational day 14 until 21, a critical period for fetal brain susceptibility to stress effects. Male and female offspring were subsequently assessed at postnatal day 24 for anxiety- and depressive-like behaviors, and spontaneous social interaction...
May 17, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29771870/hyperfibrinolysis-is-an-important-cause-of-early-hemorrhage-in-patients-with-acute-promyelocytic-leukemia
#11
Yu-Hua Song, Chun Qiao, Li-Chan Xiao, Run Zhang, Hua - Lu
BACKGROUND The objective of the current study was to guide the early clinical treatment strategies by assessing the recovery of abnormal coagulation in acute promyelocytic leukemia (APL) patients during induction therapy. MATERIAL AND METHODS Retrospective analysis was performed in 112 newly-diagnosed patients with APL during induction treatment. RESULTS The early death (ED) rate in our study was 5.36% and the main cause was fetal hemorrhage. The presence of bleeding symptoms was significantly correlated with low platelet and fibrinogen levels...
May 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29770967/developmental-programming-of-renal-function-nephron-endowment-and-beyond
#12
Andrew G Woodman, Stephane L Bourque
In the face of adversity, the fetal kidney doesn't fare well. When resources are limiting due to pregnancy complications such as placental insufficiency, maternal hypoxia, or nutrient deficiencies, kidney development is often compromised, showing signs of reduced growth, defective nephrogenesis, and abnormal morphology. This article is protected by copyright. All rights reserved.
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29770755/body-composition-during-early-infancy-and-developmental-progression-from-1-to-5-years-of-age-the-infant-anthropometry-and-body-composition-iabc-cohort-study-among-ethiopian-children
#13
Mubarek Abera, Markos Tesfaye, Bitiya Admassu, Charlotte Hanlon, Christian Ritz, Rasmus Wibaek, Kim F Michaelsen, Henrik Friis, Jonathan C Wells, Gregers S Andersen, Tsinuel Girma, Pernille Kæstel
Early nutrition and growth have been found to be important early exposures for later development. Studies of crude growth in terms of weight and length/height, however, cannot elucidate how body composition (BC) might mediate associations between nutrition and later development. In this study, we aimed to examine the relation between fat mass (FM) or fat-free mass (FFM) tissues at birth and their accretion during early infancy, and later developmental progression. In a birth cohort from Ethiopia, 455 children who have BC measurement at birth and 416 who have standardised rate of BC growth during infancy were followed up for outcome variable, and were included in the statistical analysis...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29769646/long-term-impacts-of-prenatal-synthetic-glucocorticoids-exposure-on-functional-brain-correlates-of-cognitive-monitoring-in-adolescence
#14
Liesa Ilg, Manousos Klados, Nina Alexander, Clemens Kirschbaum, Shu-Chen Li
The fetus is highly responsive to the level of glucocorticoids in the gestational environment. Perturbing glucocorticoids during fetal development could yield long-term consequences. Extending prior research about effects of prenatally exposed synthetic glucocorticoids (sGC) on brain structural development during childhood, we investigated functional brain correlates of cognitive conflict monitoring in term-born adolescents, who were prenatally exposed to sGC. Relative to the comparison group, behavioral response consistency (indexed by lower reaction time variability) and a brain correlate of conflict monitoring (the N2 event-related potential) were reduced in the sGC exposed group...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769009/mesenchymal-stem-cell-research-in-veterinary-medicine
#15
Mudasir Bashir Gugjoo, Amarpal, Vikash Chandra, Mohd Yaqoob Wani, Kuldeep Dhama, Gutulla Taru Sharma
BACKGROUND: The stem cells due to their unique characteristic features like self-renewal, multiplication, immuno-modulation and differentiation, are seen and hoped to bring new horizons in the field of biology, in general and medicine, in particular. OBJECTIVE: Among various stem cell types, currently mesenchymal stem cells (MSCs) are extensively studied in regenerative medicine owing to their readily available sources, easy harvesting and ability to differentiate both into mesodermal as well as non-mesodermal tissues with little associated ethical issues...
May 16, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29768688/ppar-%C3%AE-in-innate-and-adaptive-lung-immunity
#16
REVIEW
Samuel Philip Nobs, Manfred Kopf
The transcription factor PPAR-γ (peroxisome proliferator-activated receptor-γ) is a key regulator of lung immunity exhibiting multiple cell type specific roles in controlling development and function of the lung immune system. It is strictly required for the generation of alveolar macrophages by controlling differentiation of fetal lung monocyte precursors. Furthermore, it plays an important role in lung allergic inflammation by licensing lung dendritic cell t helper 2 (Th2) priming capacity as well as acting as a master transcription factor for pathogenic Th2 cells...
May 16, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29768660/validation-of-a-computerized-algorithm-to-quantify-fetal-heart-rate-deceleration-area
#17
Erika Gyllencreutz, Ke Lu, Kaj Lindecrantz, Pelle G Lindqvist, Lennart Nordstrom, Malin Holzmann, Farhad Abtahi
INTRODUCTION: Reliability in visual cardiotocography interpretation is unsatisfying, which has led to development of computerized cardiotocography. Computerized analysis is well established for antenatal fetal surveillance, but has yet not performed sufficiently during labor. We aimed to investigate the capacity of a new computerized algorithm compared to visual assessment in identifying intrapartum fetal heart rate baseline and decelerations. MATERIAL AND METHODS: Three-hundred-and-twelve intrapartum cardiotocography tracings with variable decelerations were analysed by the computerized algorithm and visually examined by two observers, blinded to each other and the computer analysis...
May 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29767745/preconception-maternal-iodine-status-is-positively-associated-with-iq-but-not-with-measures-of-executive-function-in-childhood
#18
Sian M Robinson, Sarah R Crozier, Elizabeth A Miles, Catharine R Gale, Philip C Calder, Cyrus Cooper, Hazel M Inskip, Keith M Godfrey
Background: Adverse effects of severe maternal iodine deficiency in pregnancy on fetal brain development are well-established, but the effects of milder deficiency are uncertain. Most studies examine iodine status in pregnancy; less is known about iodine nutrition before conception. Objective: We examined relations between maternal preconception iodine status and offspring cognitive function, within a prospective mother-offspring cohort. Methods: Maternal iodine status was assessed through the use of the ratio of iodine:creatinine concentrations (I/Cr) in spot urine samples [median (IQR) period before conception 3...
May 15, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29766818/cell-free-fetal-dna-a-novel-biomarker-for-early-prediction-of-pre-eclampsia-and-other-obstetric-complications
#19
Naina Kumar, Amit Kant Singh
Hypertensive disorder of pregnancy, especially Pre-eclampsia is one of the major causes of increased maternal and perinatal morbidity and mortality all over the world. Early prediction of pre-eclampsia is the need of modern obstetrics, as this can timely prevent the progress of disease as well as related fetal and maternal morbidity and mortality. In addition to the screening of fetal aneuploidies, Rhesus-D status, fetal sex, single gene disorders, the cell-free fetal Deoxyribonucleic acid (DNA) quantification has emerged out as a promising biomarker for prediction of pre-eclampsia...
May 16, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29766563/the-effects-of-gestational-diabetes-mellitus-on-fetal-growth-and-neonatal-birth-measures-in-an-african-cohort
#20
S Macaulay, R J Munthali, D B Dunger, S A Norris
AIM: Fetal exposure to gestational diabetes mellitus (GDM) is said to alter fetal growth and increase the risk of macrosomia. However, little research on GDM exists in African populations. This study aimed to assess longitudinal fetal growth and neonatal birth measures among Black African babies exposed to GDM. METHODS: Pregnant women (Soweto, South Africa) enrolled into a cohort study were followed up with repeated fetal ultrasounds. At 24-28 weeks' gestation a 2-h 75 g oral glucose tolerance test was performed and GDM was diagnosed using the World Health Organization's 2013 criteria...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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