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https://www.readbyqxmd.com/read/29889240/outcomes-of-patients-lost-to-follow-up-in-african-antiretroviral-therapy-programs-individual-patient-data-meta-analysis
#1
Frédérique Chammartin, Kathrin Zürcher, Olivia Keiser, Ralf Weigel, Kathryn Chu, Agnes N Kiragga, Cristina Ardura-Garcia, Nanina Anderegg, Christian Laurent, Morna Cornell, Hannock Tweya, Andreas D Haas, Brian D Rice, Elvin H Geng, Matthew P Fox, James R Hargreaves, Matthias Egger
Background: Low retention on combination antiretroviral therapy (cART) has emerged as a threat to the Joint United Nations Programme on human immunodeficiency virus (HIV)/AIDS (UNAIDS) 90-90-90 targets. We examined outcomes of patients who started cART but were subsequently lost to follow-up (LTFU) in African treatment programs. Methods: This was a systematic review and individual patient data meta-analysis of studies that traced patients who were LTFU. Outcomes were analyzed using cumulative incidence functions and proportional hazards models for the competing risks of (i) death, (ii) alive but stopped cART, (iii) silent transfer to other clinics, and (iv) retention on cART...
June 8, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29879908/mortality-and-associated-factors-of-patients-with-extensive-drug-resistant-tuberculosis-an-emerging-public-health-crisis-in-china
#2
Chengli Bei, Manjiao Fu, Yao Zhang, Hebin Xie, Ke Yin, Yanke Liu, Li Zhang, Bangruan Xie, Fang Li, Hua Huang, Yuhong Liu, Li Yang, Jing Zhou
BACKGROUND: Limited treatment options of extensive drug-resistant tuberculosis (XDR-TB) have led to its high mortality worldwide. Relevant data about mortality of XDR-TB patients in literature are limited and likely underestimate the real situation in China, since the majority of patients with XDR-TB are lost to follow-up after discharge from TB hospitals. In this study, we sought to investigate the mortality and associated risk factors of Human Immunodeficiency Virus (HIV)-negative patients with XDR-TB in China...
June 7, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29813169/outpatient-total-shoulder-arthroplasty-does-not-increase-the-90-day-risk-of-complications-compared-with-inpatient-surgery-in-prescreened-patients
#3
Chima D Nwankwo, Pascual Dutton, Jarrad A Merriman, Gio Gajudo, Kanwaljit Gill, Joshua Hatch
Outpatient total joint arthroplasty is becoming a more attractive option for hospitals, surgeons, and patients. In this study, the authors evaluated the safety of outpatient shoulder arthroplasty by comparing an outpatient cohort with an inpatient cohort. Ninety-day outcomes of consecutively performed elective shoulder arthroplasty cases from 2012 to 2016 were retrospectively reviewed. Patients were preoperatively assigned to outpatient or inpatient care. Primary outcomes were emergency department visits, readmissions, mortality, and surgical morbidity within 90 days of surgery...
May 29, 2018: Orthopedics
https://www.readbyqxmd.com/read/29805799/assessment-of-time-to-hospital-encounter-after-an-initial-hospitalization-for-heart-failure-results-from-a-tertiary-medical-center
#4
Nicolas W Shammas, Ryan Kelly, Jon Lemke, Ram Niwas, Sarah Castro, Christine Beuthin, Jackie Carlson, Marti Cox, Gail A Shammas, Terri DeClerck, Kathy Lenaghan, Sunny Arikat, Marcia Erickson
Background: Hospital inpatient readmissions for patients admitted initially with the primary diagnosis of heart failure (HF) can be as high as 20-25% within 30 days of discharge. This, however, does not include admissions for observations or emergency department (ED) visits within the same time frame and does not show a time-dependent hospital encounter following discharge after an index admission. We present data on time-dependent hospital encounter of HF patients discharged after an index admission for a primary diagnosis of HF...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29799328/real-world-economic-outcomes-during-time-on-treatment-among-patients-who-initiated-sunitinib-or-pazopanib-as-first-targeted-therapy-for-advanced-renal-cell-carcinoma-a-retrospective-analysis-of-medicare-claims-data
#5
Nicholas J Vogelzang, Sumanta K Pal, Sameer R Ghate, Nanxin Li, Elyse Swallow, Miranda Peeples, Miriam L Zichlin, Mark K Meiselbach, Jose Ricardo Perez, Neeraj Agarwal
BACKGROUND: The median age at renal cell carcinoma (RCC) diagnosis is 64 years. However, few studies have assessed the real-world time on treatment (TOT), health resource utilization (HRU), costs, or treatment compliance associated with targeted therapy use among patients in this age group with RCC. OBJECTIVE: To assess the HRU, costs, and compliance during TOT among Medicare patients aged ≥ 65 years with advanced RCC (aRCC) who initiated first targeted therapy with pazopanib or sunitinib...
June 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29799325/the-relationship-between-guideline-recommended-initiation-of-therapy-outcomes-and-cost-for-patients-with-metastatic-non-small-cell-lung-cancer
#6
Adrianne Casebeer, Dana Drzayich Antol, Richard W DeClue, Sari Hopson, Yong Li, Raya Khoury, Todd Michael, Marina Sehman, Aparna Parikh, Stephen Stemkowski, Mikele Bunce
BACKGROUND: Guideline-recommended therapy for metastatic non-small cell lung cancer (mNSCLC) encourages evidence-based treatment; however, there is a knowledge gap regarding the influence of guideline-recommended initiation of therapy on outcomes and cost. OBJECTIVE: To investigate if lack of guideline-recommended initiation of first-line systemic therapy was associated with worse patient outcomes and increased costs for patients with mNSCLC. METHODS: In this retrospective analysis, 1,344 Medicare patients with mNSCLC were identified from Humana data...
June 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29794038/perceived-social-isolation-and-outcomes-in-patients-with-heart-failure
#7
Sheila M Manemann, Alanna M Chamberlain, Véronique L Roger, Joan M Griffin, Cynthia M Boyd, Thomas K M Cudjoe, Daniel Jensen, Susan A Weston, Matteo Fabbri, Ruoxiang Jiang, Lila J Finney Rutten
BACKGROUND: Perceived social isolation has been shown to have a negative impact on health outcomes, particularly among older adults. However, these relationships have not been fully examined among patients with heart failure. METHODS AND RESULTS: Residents from 11 southeast Minnesota counties with a first-ever International Classification of Diseases, Ninth Revision ( ICD-9 ) code 428 for heart failure between January 1, 2013, and March 31, 2015 (N=3867), were prospectively surveyed to measure perceived social isolation...
May 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29777613/risk-of-injury-after-evening-and-night-work-findings-from-the-danish-working-hour-database
#8
Helena B Nielsen, Ann D Larsen, Johnny Dyreborg, Åse M Hansen, Lisa A Pompeii, Sadie H Conway, Johnni Hansen, Henrik A Kolstad, Kirsten Nabe-Nielsen, Anne H Garde
Objectives Evening and night work have been associated with higher risk of injury than day work. However, previous findings may be affected by recall bias and unmeasured confounding from differences between day, evening and night workers. This study investigates whether evening and night work during the past week increases risk of injury when reducing recall bias and unmeasured confounding. Methods We linked daily working hours at the individual level of 69 200 employees (167 726 person years from 2008-2015), primarily working at hospitals to registry information on 11 834 injuries leading to emergency room visits or death...
May 8, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29757869/end-of-life-care-for-patients-with-advanced-ovarian-cancer-is-aggressive-despite-hospice-intervention-a-population-based-study
#9
Jui-Kun Chiang, Chun-Shuo Hsu, Chih-Wen Lin, Yee-Hsin Kao
OBJECTIVE: To date, few studies have examined end-of-life (EOL) care and healthcare costs for patients with ovarian cancer. We evaluated the effects of hospice care on the quality of EOL care and healthcare costs for patients with ovarian cancer in the final month of life. MATERIALS AND METHODS: We conducted a population-based study and analyzed data from Taiwan's Longitudinal Health Insurance Database, which contains claims information for medical records of patients, healthcare costs, and insurance system exit dates: our proxy for death between 1997 and 2011...
May 11, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29756746/factors-influencing-consent-to-organ-donation-after-brain-death-certification-a-survey-of-29-intensive-care-units
#10
Guya Piemonte, Maria L Migliaccio, Stefano Bambi, Marco Bombardi, Lorenzo D'antonio, Andrea Guazzini, Caterina Di Pasquale, Laura Tadini-Buoninsegni, Cristiana Guetti, Manuela Bonizzoli, Sara Bagatti, Paolo Lopane, Anna Nativi, Laura Rasero, Adriano Peris
BACKGROUND: Family refusal (FR) to heart beating donation (HBD) in Intensive Care Unit (ICU) is increasing in recent years with a significant impact on the number of transplantable organs. Fostering setting humanization, quality of relationships, respect for will and family reliance towards ICU could be relevant in containing FR to organ donation (OD) in ICU. Our aims were to highlight the effects of structural features of ICUs and humanization determinants on FR in HBD process, and to describe visiting policies, structure and modalities of support in ICUs...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29747934/predictors-of-critical-care-and-mortality-in-bronchiolitis-after-emergency-department-discharge
#11
Suzanne Schuh, Jeffrey C Kwong, Laura Holder, Erin Graves, Erin M Macdonald, Yaron Finkelstein
OBJECTIVES: To identify the epidemiologic predictors and stratify the risk of critical care unit (CCU) admission or death in bronchiolitis following emergency department discharge. This information has not yet been explored. STUDY DESIGN: A population-based cohort study using Ontario-wide demographic and healthcare databases linked at the individual level. We assessed all infants with bronchiolitis discharged home from all emergency departments in Ontario, Canada, 2003-2014...
April 24, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29723341/impact-of-discharge-medication-counseling-in-the-cardiology-unit-of-a-tertiary-hospital-in-brazil-a-randomized-controlled-trial
#12
Aline F Bonetti, Bruna Q Bagatim, Antonio M Mendes, Inajara Rotta, Renata C Reis, Maria Luiza D Fávero, Fernando Fernandez-Llimós, Roberto Pontarolo
OBJECTIVES: This study aimed to evaluate the impact of pharmacist-provided discharge counseling on mortality rate, hospital readmissions, emergency department visits, and medication adherence at 30 days post discharge. METHODS: This randomized controlled trial was approved by the local ethics committee and included patients aged 18 years or older admitted to the cardiology ward of a Brazilian tertiary hospital. The intervention group received a pharmacist-led medication counseling session at discharge and a telephone follow-up three and 15 days after discharge...
2018: Clinics
https://www.readbyqxmd.com/read/29689595/potentially-inappropriate-medication-use-in-older-patients-with-breast-and-colorectal-cancer
#13
Meghan S Karuturi, Holly M Holmes, Xiudong Lei, Michael Johnson, Carlos H Barcenas, Scott B Cantor, Gary E Gallick, Robert C Bast, Sharon H Giordano
BACKGROUND: The objective of this study was to determine patient characteristics associated with potentially inappropriate medication (PIM) use and its impact on outcomes for patients with breast or colorectal cancer receiving adjuvant chemotherapy. METHODS: The Surveillance, Epidemiology, and End Results database, linked to Medicare claims, was used. The cohort included patients who were 66 years old or older and were diagnosed with stage II or III breast or colorectal cancer between July 1, 2007, and December 31, 2009...
April 24, 2018: Cancer
https://www.readbyqxmd.com/read/29672398/evaluating-quality-metrics-and-cost-after-discharge-a-population-based-cohort-study-of-value-in-health-care-following-elective-major-vascular-surgery
#14
Charles de Mestral, Konrad Salata, Mohamad A Hussain, Ahmed Kayssi, Mohammed Al-Omran, Graham Roche-Nagle
BACKGROUND: Early readmission to hospital after surgery is an omnipresent quality metric across surgical fields. We sought to understand the relative importance of hospital readmission among all health services received after hospital discharge. OBJECTIVE: The aim of this study was to characterize 30-day postdischarge cost and risk of an emergency department (ED) visit, readmission, or death after hospitalization for elective major vascular surgery. METHODS: This is a population-based retrospective cohort study of patients who underwent elective major vascular surgery - carotid endarterectomy, EVAR, open AAA repair, bypass for lower extremity peripheral arterial disease - in Ontario, Canada, between 2004 and 2015...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29661050/healthcare-resource-use-and-costs-associated-with-chronic-kidney-disease-in-us-private-insurance-patients-with-multiple-myeloma
#15
Debajyoti Bhowmik, Xue Song, Michele Intorcia, Shia T Kent, Nianwen Shi
Objectives Within a median 1.2 years after patients have an initial diagnosis with multiple myeloma, up to 61% were diagnosed with renal impairment and 50% were diagnosed with chronic kidney disease. This study estimated economic burden associated with chronic kidney disease in multiple myeloma patients in the US. Methods In this retrospective cohort study, patients ≥18 years old with ≥1 inpatient or ≥ 2 outpatient multiple myeloma diagnoses between 1 January 2008 and 31 March 2015 were identified from MarketScan® Commercial and Medicare Supplemental Databases...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29656265/classification-of-attempted-suicide-by-cluster-analysis-a-study-of-888-suicide-attempters-presenting-to-the-emergency-department
#16
Hyeyoung Kim, Bora Kim, Se Hyun Kim, C Hyung Keun Park, Eun Young Kim, Yong Min Ahn
BACKGROUND: It is essential to understand the latent structure of the population of suicide attempters for effective suicide prevention. The aim of this study was to identify subgroups among Korean suicide attempters in terms of the details of the suicide attempt. METHODS: A total of 888 people who attempted suicide and were subsequently treated in the emergency rooms of 17 medical centers between May and November of 2013 were included in the analysis. The variables assessed included demographic characteristics, clinical information, and details of the suicide attempt assessed by the Suicide Intent Scale (SIS) and Columbia-Suicide Severity Rating Scale (C-SSRS)...
August 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29652166/ambulance-use-distance-and-outcomes-in-patients-with-suspected-cardiovascular-disease-a-registry-based-geographic-information-system-study
#17
Nariman Sepehrvand, Wendimagegn Alemayehu, Padma Kaul, Rick Pelletier, Aminu K Bello, Robert C Welsh, Paul W Armstrong, Justin A Ezekowitz
BACKGROUND: Despite guideline recommendations, the majority of patients with symptoms suggestive of acute coronary syndrome do not use emergency medical services to reach the emergency department (ED). The aim of this study was to investigate the factors associated with EMS utilisation and subsequent patient outcomes. METHODS: Using administrative data, all patients who presented to an ED in the metropolitan areas of Edmonton and Calgary in the years of 2007-2013 with main ED diagnosis of acute coronary syndrome, stable angina or chest pain were included...
April 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29650872/-examination-of-patients-that-died-within-48-hours-after-urgent-hospitalization
#18
Kazuhiro Kawada, Ryota Yanaizumi, Osamu Takahashi
We offer inpatient support for end-stage cancer patients, not only in palliative care units, but also in general medical and long-term care units. We also provide outpatient palliative care and offer emergent backup for the regional home care clinics. From January 2014 to December 2016, 1,832 patients were hospitalized, and among them, 983 patients visited our hospital on an emergency basis. Among the urgent hospitalized patients, 378 patients returned home after adequate palliative care. But 605 patients had to stay admitted in the hospital until their time of death...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29626743/examining-racial-ethnic-differences-in-patterns-of-benzodiazepine-prescription-and-misuse
#19
Benjamin Cook, Timothy Creedon, Ye Wang, Chunling Lu, Nicholas Carson, Piter Jules, Esther Lee, Margarita Alegría
BACKGROUND: Benzodiazepines (BZDs) are widely prescribed during psychiatric treatment. Unfortunately, their misuse has led to recent surges in overdose emergency visits and drug-related deaths. METHODS: Electronic health record data from a large healthcare system were used to describe racial/ethnic, sex, and age differences in BZD use and dependence. Among patients with a BZD prescription, we assessed differences in the likelihood of subsequently receiving a BZD dependence diagnosis, number of BZD prescriptions, receiving only one BZD prescription, and receiving 18 or more BZD prescriptions...
June 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29610668/hcfc-123-induced-toxic-hepatitis-and-death-at-a-korean-fire-extinguisher-manufacturing-facility-a-case-series
#20
Mu Young Shin, Jong Soo Park, Hae Dong Park, Jihye Lee
Background: Exposure to sustained high concentrations of HCFC-123 is known to be hepatotoxic. We report two simultaneous cases of toxic hepatitis related to exposure to 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123), a common refrigerant, at a Korean fire extinguisher manufacturing facility. Case presentation: Patients A and B were men aged 21 and 22 years, respectively, with no notable medical histories. They had recently started working for a manufacturer of fire extinguishers...
2018: Annals of Occupational and Environmental Medicine
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