keyword
MENU ▼
Read by QxMD icon Read
search

Long acting injections

keyword
https://www.readbyqxmd.com/read/28921908/biphasic-insulin-aspart-30-reduces-glycemic-variability-to-a-greater-degree-than-insulin-detemir-a-randomized-controlled-trial-of-once-daily-insulin-regimens-using-continuous-glucose-monitoring
#1
Daisuke Tsujino, Rimei Nishimura, Yoshiko Onda, Chiaki Seo, Kiyotaka Ando, Kazunori Utsunomiya
INTRODUCTION: We compared the efficacy of insulin detemir and biphasic insulin aspart-30 given in the morning as an add-on to oral hypoglycemic agents (OHAs) in type 2 diabetic patients. MATERIALS AND METHODS: This study enrolled 30 patients with poorly controlled type 2 diabetes (8%≤HbA1c<11%) being treated with OHA mono- or combination therapy with biguanides, sulfonylureas, or thiazolidinediones. The patients were randomly assigned to insulin detemir (group D) or insulin aspart-30 (group A) given in the morning as add-on to OHAs...
September 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28919292/treatment-patterns-health-care-resource-utilization-and-spending-in-medicaid-beneficiaries-initiating-second-generation-long-acting-injectable-agents-versus-oral-atypical-antipsychotics
#2
Dominic Pilon, Neeta Tandon, Marie-Hélène Lafeuille, Rhiannon Kamstra, Bruno Emond, Patrick Lefebvre, Kruti Joshi
PURPOSE: Second-generation long-acting injectable therapies (SGA-LAIs) may reduce health care resource utilization (HRU) and health care costs compared with daily oral atypical antipsychotics (OAAs) in patients with schizophrenia due to reduced dosing frequency, delivery/monitoring by a health care provider, and improved adherence. The aim of the present study was to compare treatment patterns, HRU, and Medicaid spending in patients with schizophrenia initiated on SGA-LAIs (overall and according to agent) versus OAAs...
September 14, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28914803/achieving-congestion-mitigation-using-distributed-power-control-for-spectrum-sensor-nodes-in-sensor-network-aided-cognitive-radio-ad-hoc-networks
#3
Long Zhang, Haitao Xu, Fan Zhuo, Hucai Duan
The data sequence of spectrum sensing results injected from dedicated spectrum sensor nodes (SSNs) and the data traffic from upstream secondary users (SUs) lead to unpredictable data loads in a sensor network-aided cognitive radio ad hoc network (SN-CRN). As a result, network congestion may occur at a SU acting as fusion center when the offered data load exceeds its available capacity, which degrades network performance. In this paper, we present an effective approach to mitigate congestion of bottlenecked SUs via a proposed distributed power control framework for SSNs over a rectangular grid based SN-CRN, aiming to balance resource load and avoid excessive congestion...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28913659/will-gay-and-bisexual-men-taking-oral-pre-exposure-prophylaxis-prep-switch-to-long-acting-injectable-prep-should-it-become-available
#4
Steven A John, Thomas H F Whitfield, H Jonathon Rendina, Jeffrey T Parsons, Christian Grov
Oral pre-exposure prophylaxis (PrEP) is highly effective at reducing HIV transmission risk and is CDC recommended for many gay, bisexual, and other men who have sex with men (GBM). We sought to investigate awareness of and preference for using long-acting injectable PrEP (LAI-PrEP) among GBM currently taking oral PrEP (n = 104), and identify their concerns. About half of GBM had heard of LAI-PrEP, and 30.8% specifically preferred LAI-PrEP. GBM with more concerns about the level of protection and drug half-life of LAI-PrEP had lower odds of preferring LAI-PrEP...
September 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28903828/pharmacokinetics-of-single-bolus-subcutaneous-cefovecin-in-c57bl-6-mice
#5
Kevin L Sanders, Esperanza Bas, Sherry K Cox, Daniel E Rothen
Because of its extended half-life, cefovecin is a broad-spectrum cephalosporin antibiotic commonly used to treat dermatitis in dogs and cats. A single injection in dogs can yield an effective plasma concentration for as long as 14 d, depending on the strain of Staphylococcus and for as long as 7 d in cats for the treatment of Pasteurella multocida. In the laboratory animal setting, C57BL/6 mice are commonly affected with dermatologic conditions that make these animals unsuitable for experiments. Therefore, we performed this pharmacokinetic study to determine whether cefovecin would be of benefit in mice...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28895766/adherence-persistence-and-inpatient-utilization-among-adult-schizophrenia-patients-using-once-monthly-versus-twice-monthly-long-acting-atypical-antipsychotics
#6
Dominic Pilon, Matthew Alcusky, Yongling Xiao, Philippe Thompson-Leduc, Marie-Hélène Lafeuille, Patrick Lefebvre, Carmela Benson
AIMS: We compared healthcare resource utilization (HRU), healthcare costs, adherence, and persistence among adult patients with schizophrenia using once-monthly (OM) versus twice-monthly (TM) atypical long-acting injectable (LAI) antipsychotic (AP) therapy. MATERIALS AND METHODS: A longitudinal retrospective cohort study was conducted using Medicaid claims data. Patients initiated on aripiprazole or paliperidone palmitate were assigned to the OM cohort; risperidone-treated patients were assigned to the TM cohort...
September 12, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28895758/medication-adherence-and-discontinuation-of-long-acting-injectable-versus-oral-antipsychotics-in-patients-with-schizophrenia-or-bipolar-disorder
#7
Mallik Greene, Jessie Tingjian Yan, Eunice Chang, Ann Hartry, Maëlys Touya, Michael S Broder
AIMS: To examine medication adherence and discontinuation in two separate groups of patients with schizophrenia or bipolar disorder (BD), who initiated a long-acting injectable (LAI) antipsychotic versus those who changed to a different oral antipsychotic monotherapy. MATERIALS AND METHODS: The Truven Health Analytics MarketScan Multi-State Medicaid claims database was used to identify patients with schizophrenia. Both Truven Health Analytics MarketScan Commercial and Medicaid claims databases were used to identify patients with BD...
September 12, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28894357/advances-in-the-delivery-of-buprenorphine-for-opioid-dependence
#8
REVIEW
Richard N Rosenthal, Viral V Goradia
Opioid use disorders (OUDs) have long been a global problem, but the prevalence rates have increased over 20 years to epidemic proportions in the US, with concomitant increases in morbidity and all-cause mortality, but especially opioid overdose. These increases are in part attributable to a several-fold expansion in the prescription of opioid pain medications over the same time period. Opioid detoxification and psychosocial treatments alone have each not yielded sufficient efficacy for OUD, but μ-opioid receptor agonist, partial agonist, and antagonist medications have demonstrated the greatest overall benefit in OUD treatment...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28888334/preparation-characterization-and-application-of-long-acting-fsh-analogs-for-assisted-reproduction
#9
David Ben-Menahem
Assisted reproduction technologies are widely used in humans and domestic animals and often include follicle stimulating hormone (FSH) in the protocol. One limitation with most of the available FSH preparations is the relative short half-life in the circulation that dictates multiple daily injections for the desired follicle development and superovulation. The development of bioactive long-acting structurally modified FSH analogs is desirable for human and veterinary use. In addition, optimal preparations and/or formulations are expected to improve the regimen and efficiency of the treatment...
September 6, 2017: Theriogenology
https://www.readbyqxmd.com/read/28886016/twelve-month-contraceptive-continuation-among-women-initiating-short-and-long-acting-reversible-contraceptives-in-north-kivu-democratic-republic-of-the-congo
#10
Sara E Casey, Amy Cannon, Benjamin Mushagalusa Balikubirhi, Jean-Bosco Muyisa, Ribka Amsalu, Maria Tsolka
CONTEXT: Despite the inclusion of sexual and reproductive health (SRH) services in the minimum standards of health care in humanitarian settings, access to SRH services, and especially to contraception, is often compromised in war. Very little is known about continuation and switching of contraceptive methods in these settings. An evaluation of a contraceptive services program in North Kivu, Democratic Republic of the Congo (DRC) was conducted to measure 12-month contraceptive continuation by type of contraceptive method (short-acting or long-acting)...
2017: PloS One
https://www.readbyqxmd.com/read/28880541/selenomethionine-as-a-safer-substitute-for-barium-selenate-in-long-acting-injectable-se-supplements-for-food-producing-animals
#11
Scott O Knowles, Neville D Grace
Nutritional supplementation with selenium (Se) can prevent Se deficiency in food-producing animals. Injection with slow-release formulations is a preferred method for free-range grazing sheep and cattle, and barium selenate (BaSeO4) provides optimal efficacy. This chemical can become a health risk to humans if the concentrated depot of an injection site is consumed, and consequently such use is recently banned in the EU. A possible replacement is selenomethionine (SeMet), a naturally occurring form of Se supplementation hitherto only administered orally...
September 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28875478/erratum-to-effectiveness-adverse-effects-and-drug-compliance-of-long-acting-injectable-risperidone-in-children-and-adolescents
#12
Mehmet Fatih Ceylan, Betül Erdogan, Selma Tural Hesapcioglu, Esra Cop
No abstract text is available yet for this article.
October 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28869705/long-acting-injectable-antipsychotics-for-prevention-and-management-of-violent-behaviour-in-psychotic-patients
#13
REVIEW
Pavel Mohr, Pavel Knytl, Veronika Voráčková, Anna Bravermanová, Tomáš Melicher
BACKGROUND AND AIMS: It has been well established that long-term antipsychotic treatment prevents relapse, lowers number of rehospitalisations, and also effectively reduces violent behaviour. Although violent behaviour is not a typical manifestation of schizophrenia or other psychotic disorders, the diagnosis of psychosis increases the overall risk of violence. One of the few modifiable factors of violence risk is adherence with medication. In contrast, non-adherence with drug treatment and subsequent relapse increases risk of violent acts...
September 4, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28858839/axonal-excitability-and-conduction-alterations-caused-by-levobupivacaine-in-rat
#14
Seçkin Tuncer, Tülay Tuncer Peker, İlksen Burat, Erhan Kiziltan, Barkin İlhan, Nizamettin Dalkiliç
In this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action potential (CNAP) recordings were performed using the suction method over sciatic nerves of Wistar rats before and after administration of 0.05 % (1.7 mmol L-1) levobupivacaine. Levobupivacaine caused complete CNAP area and amplitude depression by blocking conduction in a time-dependent manner...
September 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28857071/oleic-acid-in-the-ventral-tegmental-area-inhibits-feeding-food-reward-and-dopamine-tone
#15
Cecile Hryhorczuk, Zhenyu Sheng, Léa Décarie-Spain, Nicolas Giguère, Charles Ducrot, Louis-Éric Trudeau, Vanessa Routh, Thierry Alquier, Stephanie Fulton
Long-chain fatty acids (FA) act centrally to decrease food intake and hepatic glucose production and alter hypothalamic neuronal activity in a manner that depends on FA type and cellular transport proteins. However, it is not known if FA are sensed by ventral tegmental area (VTA) dopamine (DA) neurons to control food-motivated behavior and DA neurotransmission. We investigated the impact of the monounsaturated FA oleate in the VTA on feeding, locomotion, food reward and DA neuronal activity and DA neuron expression of FA handling proteins and FA uptake...
August 31, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28854082/protein-engineering-to-increase-the-potential-of-a-therapeutic-antibody-fab-for-long-acting-delivery-to-the-eye
#16
Devin Tesar, Jacob Luoma, Emily A Wyatt, Catherine Shi, Whitney Shatz, Philip E Hass, Mary Mathieu, Li Yi, Jacob E Corn, Katie F Maass, Kathryn Wang, Michelle Z Dion, Nisana Andersen, Kelly M Loyet, Menno van Lookeren Campagne, Karthikan Rajagopal, Leslie Dickmann, Justin M Scheer, Robert F Kelley
To date, ocular antibody therapies for the treatment of retinal diseases rely on injection of the drug into the vitreous chamber of the eye. Given the burden for patients undergoing this procedure, less frequent dosing through the use of long-acting delivery (LAD) technologies is highly desirable. These technologies usually require a highly concentrated formulation and the antibody must be stable against extended exposure to physiological conditions. Here we have increased the potential of a therapeutic antibody antigen-binding fragment (Fab) for LAD by using protein engineering to enhance the chemical and physical stability of the molecule...
August 30, 2017: MAbs
https://www.readbyqxmd.com/read/28851326/dilemma-of-treating-schizophrenia-during-pregnancy-a-case-series-and-a-review-of-literature
#17
Andreea Teodorescu, Petru Ifteni, Marius Alexandru Moga, Victoria Burtea, Nicusor Bigiu
BACKGROUND: The choice of antipsychotic treatment during pregnancy remains controversial, mainly due to a lack of exposure and outcome data. Randomized clinical trials are practically impossible due to ethical reasons. Our reports describe three cases of closely monitored female patients with schizophrenia who were treated with olanzapine during pregnancy. The novelty of reports is that all patients were previously treated with olanzapine long acting injectable (LAI) for an average period of 3...
August 29, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28846912/impact-of-estradiol-cypionate-prior-to-tai-and-progesterone-supplementation-at-initial-diestrus-on-ovarian-and-fertility-responses-in-beef-cows
#18
T Martins, J P Talamoni, M Sponchiado, J R G Maio, G P Nogueira, G Pugliesi, M Binelli
In cattle, early diestrus progesterone (P4) supplementation modulates endometrial function to exert pro- and anti-pregnancy establishment effects; specifically, P4 stimulates conceptus growth, but also induces early onset of luteolysis. This paradoxical effect is frequently related to the inconsistent fertility outcomes that result from P4 supplementation experiments. Aim was to investigate the impact of exogenous estradiol (E2) treatment at the end of timed fixed AI (TAI) on frequency of early luteolysis and pregnancy of beef cows supplemented with P4...
August 19, 2017: Theriogenology
https://www.readbyqxmd.com/read/28846769/collaborative-care-for-opioid-and-alcohol-use-disorders-in-primary-care-the-summit-randomized-clinical-trial
#19
Katherine E Watkins, Allison J Ober, Karen Lamp, Mimi Lind, Claude Setodji, Karen Chan Osilla, Sarah B Hunter, Colleen M McCullough, Kirsten Becker, Praise O Iyiewuare, Allison Diamant, Keith Heinzerling, Harold Alan Pincus
Importance: Primary care offers an important and underutilized setting to deliver treatment for opioid and/or alcohol use disorders (OAUD). Collaborative care (CC) is effective but has not been tested for OAUD. Objective: To determine whether CC for OAUD improves delivery of evidence-based treatments for OAUD and increases self-reported abstinence compared with usual primary care. Design, Setting, and Participants: A randomized clinical trial of 377 primary care patients with OAUD was conducted in 2 clinics in a federally qualified health center...
August 28, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28843143/effects-of-oral-versus-long-acting-antipsychotics-on-social-functioning-a-psychiatrists-survey-in-india
#20
Prasad Rao Gundugurti, Rajesh Nagpal, Ashit Sheth, Prashant Narang, Sonal Gawande, Vikram Singh
BACKGROUND: Schizophrenia is associated with functional challenges for patients; relapses in schizophrenia may lead to increased treatment costs and poor quality of life. OBJECTIVE: This SUSTAIN-I study was conducted to establish psychiatrists' perspective on impact of long-acting injectables (LAIs) antipsychotics on the socio-economic and functional burden of schizophrenia. METHODS: This cross-sectional, survey-based study was conducted in 5 cities in India...
August 9, 2017: Asian Journal of Psychiatry
keyword
keyword
62763
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"