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Endometrial pathology

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https://www.readbyqxmd.com/read/28442471/development-of-organoids-from-mouse-and-human-endometrium-showing-endometrial-epithelium-physiology-and-long-term-expandability
#1
Matteo Boretto, Benoit Cox, Manuel Noben, Nikolai Hendriks, Amelie Fassbender, Heleen Roose, Frédéric Amant, Dirk Timmerman, Carla Tomassetti, Arne Vanhie, Christel Meuleman, Marc Ferrante, Hugo Vankelecom
The endometrium, which is of crucial importance for reproduction, undergoes dynamic cyclic tissue remodeling. Knowledge of its molecular and cellular regulation is poor, primarily owing to a lack of study models. Here, we have established a novel and promising organoid model from both mouse and human endometrium. Dissociated endometrial tissue, embedded in Matrigel under WNT-activating conditions, swiftly formed organoid structures that showed long-term expansion capacity, and reproduced the molecular and histological phenotype of the tissue's epithelium...
April 25, 2017: Development
https://www.readbyqxmd.com/read/28441840/-atypical-polypoid-adenomyoma-of-the-uterus-a-clinicopathological-review-of-27-cases
#2
T J Bai, D M Bao, Y Li, Y Wang, H Cui, H L Zhu
Objective: To investigate the clinical and pathological characteristics of atypical polypoid adenomyoma (APA) for improvement of the diagnosis, different diagnosis and treatment of the disease. Methods: The clinical data, pathological characteristics, and the follow-up information were retrospectively analyzed in 27 cases of APA admitted in Peking Univeristy People's Hospital from 2007 to 2016. Results: The median age was 42.6 years old (range 25-60 years old). Fifteen patients were nullipara, 2 patients were postmenopausal...
April 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28440357/virtual-hysteroscopy-a-new-non-invasive-approach-for-the-assessment-of-uterine-cavity
#3
Paulo Sergio Cossi, Heron Werner, Alberto Borges Peixoto, Wellington P Martins, Edward Araujo Júnior
Endometrial pathology is frequent in premenopausal women and the diagnostic hysteroscopy is considered the gold standard for assessing endometrial cavity and congenital uterine anomalies. However it is an invasive and uncomfortable procedure. Saline contrast hysterosalgingography and hysterosalpingo-contrast sonography allow detailed assessment of the uterine cavity. We propose a virtual hysteroscopy from three-dimensional saline and three-dimensional hysterosalpingo-contrast sonography scan data to generate a virtual reality as a new noninvasive procedure for assessing the uterine cavity in uterine congenital anomaly and endometrial pathology cases as well...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28439599/agreement-of-histopathological-findings-of-uterine-curettage-and-hysterectomy-specimens-in-women-with-abnormal-uterine-bleeding
#4
Sanam Moradan, Raheb Ghorbani, Azita Lotfi
To examined the diagnostic value of  dilatation and curettage (D and C) in patients with abnormal uterine bleeding (AUB) by conducting a histopathological examination of endometrial tissues by D and C and hysterectomy. Methods: In this retrospective study, the medical records of 163 women who had been hospitalized  in the Obstetrics and Gynecology Ward, Amir-al-Momenin Hospital, Semnan, Iran between 2010 and 2015 for diagnostic curettage due to  AUB and who had undergone hysterectomy were investigated. The patients' characteristics and histopathologic results of curettage and hysterectomy were extracted, and sensitivity and specificity and positive and negative predictive values of curettage were calculated...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28433735/outpatient-endometrial-aspiration-an-alternative-to-methotrexate-for-pregnancy-of-unknown-location
#5
Iris G Insogna, Leslie V Farland, Stacey A Missmer, Elizabeth S Ginsburg, Paula C Brady
OBJECTIVE: To evaluate the utility of an endometrial sampling protocol for the diagnosis of pregnancies of unknown location following in vitro fertilization. STUDY DESIGN: A retrospective cohort study of 14,505 autologous fresh and frozen in vitro fertilization cycles from 10/2007 to 9/2015 was performed; 110 patients were diagnosed with pregnancy of unknown location, defined as a positive human chorionic gonadotropin (hCG) without ultrasound evidence of intrauterine or ectopic pregnancy, and an abnormal hCG trend (<53% rise or <15% fall in two days)...
April 19, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28421714/endometrial-cells-on-pap-tests-ideal-reporting-is-more-complex-than-just-finding-the-right-age-ideal-reporting-of-endometrial-cells-on-pap-tests
#6
Gabor Fischer, Maha Haddad, Karen Cormier
BACKGROUND: The age for reporting normal endometrial cells (EMCs) on Pap tests was changed to ≥ 45 years in the latest Bethesda update (2014). This recommendation is solely based on age with no consensus on optimal reporting guidelines. METHODS: Pap tests with EMCs for women ≥40 years were retrieved from our Laboratory Information System (LIS). Patient age, last menstrual period (LMP) and available follow-up histology were recorded. Follow-up diagnoses were categorized as: no significant pathology, benign, hyperplasia ± atypia, or malignant...
April 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28408123/rna-binding-proteins-in-female-reproductive-pathologies
#7
REVIEW
Kasra Khalaj, Jessica E Miller, Christian R Fenn, SooHyun Ahn, Rayana L Luna, Lindsey Symons, Stephany P Monsanto, Madhuri Koti, Chandrakant Tayade
RNA-binding proteins are key regulatory molecules involved primarily in post-transcriptional gene regulation of RNAs. Post-transcriptional gene regulation is critical for adequate cellular growth and survival. Recent reports have shown key interactions between these RNA-binding proteins and other regulatory elements, such as miRNAs and long noncoding RNAs, either enhancing or diminishing their response to RNA stabilization. Many RNA-binding proteins have been reported to play a functional role in mediation of cytokines involved in inflammation and immune dysfunction, and some have been classified as global post-transcriptional regulators of inflammation...
April 10, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28405864/g-csf-and-stem-cell-therapy-for-the-treatment-of-refractory-thin-lining-in-assisted-reproductive-technology
#8
REVIEW
Youssef Mouhayar, Fady I Sharara
PURPOSE: The study aims to describe two promising therapeutic options for resistant "thin" endometrium in fertility treatment: granulocyte colony-stimulating factor (G-CSF) and stem cell therapy. METHODS: A review of the scientific literature related to patients with thin endometrium undergoing fertility treatment. RESULTS: Sufficient endometrial growth is fundamental for embryo implantation. Whether idiopathic or resulting from an underlying pathology, a thin endometrium of <7 mm is associated with lower probability of pregnancy; however, no specific thickness excludes the occurrence of pregnancy...
April 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28405119/figo-s-palm-coein-classification-of-abnormal-uterine-bleeding-a-clinico-histopathological-correlation-in-indian-setting
#9
Devanshi Mishra, Shabana Sultan
INTRODUCTION: Abnormal uterine bleeding (AUB) is the commonest menstrual problem during perimenopause. The International Federation of Gynaecology and Obstetrics working group on menstrual disorders has developed a classification system (PALM-COEIN) for causes of the AUB in non-gravid women. The present study was conducted with the aim to study the two components of this system in clinical practice in general and to establish a clinico-pathological correlation of AUB with context of PALM component in particular...
April 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28401338/serum-he4-is-correlated-to-prognostic-factors-and-survival-in-patients-with-endometrial-cancer
#10
A Stiekema, Car Lok, C M Korse, W J van Driel, V van der Noort, G G Kenter, K K Van de Vijver
The extent of surgery and the decision for adjuvant treatment in patients with endometrial cancer (EC) depend on the presence of risk factors for lymph node metastases and disease recurrence. Postoperative markers such as myometrial infiltration and specific mutations can select patients for adjuvant treatment but will not influence surgical planning. A biomarker stratifying patients into low-risk and high-risk groups before surgery could identify patients who benefit from more extensive surgery. Therefore, we evaluated the correlation of serum biomarker HE4 with clinical and recently identified prognostic pathological variables and survival...
April 11, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28399028/pathologic-and-treatment-outcomes-among-a-geriatric-population-of-endometrial-cancer-patients-an-nrg-oncology-gynecologic-oncology-group-ancillary-data-analysis-of-lap2
#11
Erin A Bishop, James J Java, Kathleen N Moore, Joan L Walker
OBJECTIVES: Elderly endometrial cancer patients have worse disease-specific survival than their younger counterparts, but the cause for this discrepancy is unknown. The goal of this analysis is to compare outcomes by age in a fully staged elderly endometrial cancer population. METHODS/MATERIALS: This is an analysis of patients on Gynecologic Oncology Group Study (GOG) LAP2, which included clinically early stage endometrial cancer patients randomized to laparotomy versus laparoscopy for surgical staging...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28397763/endoplasmic-reticulum-stress-and-homeostasis-in-reproductive-physiology-and-pathology
#12
REVIEW
Elif Guzel, Sefa Arlier, Ozlem Guzeloglu-Kayisli, Mehmet Selcuk Tabak, Tugba Ekiz, Nihan Semerci, Kellie Larsen, Frederick Schatz, Charles Joseph Lockwood, Umit Ali Kayisli
The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts directly or indirectly with several cell organelles i.e., Golgi bodies, mitochondria and proteasomes. The ER is usually associated with large numbers of attached ribosomes. During evolution, ER developed as the specific cellular site of synthesis, folding, modification and trafficking of secretory and cell-surface proteins. The ER is also the major intracellular calcium storage compartment that maintains cellular calcium homeostasis...
April 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28395052/assessment-of-the-intraoperative-consultation-service-rendered-by-general-pathologists-in-a-scenario-where-a-well-defined-decision-algorithm-is-followed
#13
Mahmoud A Khalifa, Sherine Salama, Rachel I Vogel, Molly E Klein, James Richter, Tanya Pulver, Sally A Mullany, Boris Winterhoff
Objectives: Intraoperative consultation (IOC) remains an area of general practice even within subspecialized pathology departments. This study assesses the IOCs rendered in a general pathology setting where surgeons integrate these results in a well-defined algorithm, developed with the input of specialized pathologists. Methods: The surgical decisions to perform lymphadenectomy in patients with endometrial adenocarcinoma operated on at our institution between January 2003 and June 2015 as a result of the IOC assessment of tumor size, histologic grade, and depth of invasion in the hysterectomy specimen were analyzed...
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28392124/surgical-pathological-findings-in-type-1-and-2-endometrial-cancer-an-nrg-oncology-gynecologic-oncology-group-study-on-gog-210-protocol
#14
William T Creasman, Shamshad Ali, David G Mutch, Richard J Zaino, Matthew A Powell, Robert S Mannel, Floor J Backes, Paul A DiSilvestro, Peter A Argenta, Michael L Pearl, Shashikant B Lele, Saketh R Guntupalli, Steven Waggoner, Nick Spirtos, John F Boggess, Robert P Edwards, Virginia L Filiaci, David S Miller
OBJECTIVE: To report clinical and pathologic relationships with disease spread in endometrial cancer patients. METHODS: Surgical candidates with uterine cancer (adenocarcinoma or carcinosarcoma) who were eligible to participate in a surgical pathological study to create a clinically annotated tissue biorepository to support translational and clinical research studies. All patients were to undergo a hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy...
April 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28389908/validation-of-rem-score-to-predict-endometrial-cancer-in-patients-with-ultrasound-endometrial-abnormalities-results-of-a-new-independent-dataset
#15
Francesco Plotti, Stella Capriglione, Corrado Terranova, Roberto Montera, Giuseppe Scaletta, Salvatore Lopez, Daniela Luvero, Antonelli Gianina, Alessia Aloisi, Pierluigi Benedetti Panici, Roberto Angioli
The risk of endometrial malignancy (REM) score is a model formulated in a previous single-center validation study, which has been shown to predict endometrial cancer in women with ultrasound endometrial abnormalities based on multiple features (clinical, ultrasound and laboratorial). The purpose of this study was to validate the performance of REM score in an external validation setting. A population-based database with patients, who underwent elective hysteroscopy for ultrasound endometrial abnormalities between 2013 and 2016 at Department of Obstetrics and Gynecology of Campus Bio-medico of Rome, was used...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28373922/a-64-year-old-woman-with-chest-pain-limb-weakness-and-endometrial-cancer
#16
Simon Ponthus, Omar Kherad, Nicole Petriccioli, Johannes Alexander Lobrinus, Pierre-André A Guerne
Necrotizing autoimmune myopathy (NAM) is a rare subgroup of idiopathic inflammatory myopathies (IIM). This pathology usually affects proximal limb muscles and in some cases the myocardium. Patients usually display proximal limb weakness. Muscular biopsy is required to confirm the diagnosis. We report the case of a 64-year-old woman with an atypical first presentation of NAM, manifested by chest pain in the context of metastatic endometrial cancer. The diagnosis of NAM was however made when she returned a second time with proximal limb weakness...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/28368791/-fertility-sparing-management-of-endometrial-cancer-and-atypical-hyperplasia
#17
C Gonthier, A Trefoux-Bourdet, D Luton, M Koskas
The fertility sparing management of endometrial cancer and atypical hyperplasia concern women in childbearing age with stage 1, grade 1, endometrioid adenocarcinoma confined to endometrium or atypical hyperplasia (simple or complex). These pathologies affecting more frequently postmenopausal women, the number of people involved is relatively low. The main risk factor is hyperestrogenism and these patients often present a history of infertility with a desire for pregnancy. The recommendations for this conservative management are scarce and unclear...
February 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28365933/preoperative-assessment-in-endometrial-cancer-is-triage-for-lymphadenectomy-possible
#18
Panagiotis Tsikouras, Zacharoula Koukouli, Anastasia Bothou, Bachar Manav, George Iatrakis, Stefanos Zervoudis, George Galazios, Alexander Tobias Teichmann
PURPOSE: We sought to examine whether a preoperative assessment with usual means, available in most hospitals (preoperative histology, pelvic MRI, serum CA-125) can confidently exclude from a full staging surgical procedure low-risk endometrial carcinoma (EC) patients according to ESMO-ESTRO-ESGO criteria (stage I endometrioid EC, grade 1 or 2, myometrial invasion <50% and negative lymphovascular space invasion). METHODS: We retrospectively identified all EC patients that underwent total hysterectomy with bilateral salpingo-oophorectomy (TH-BSO) plus lymph node dissection (LND) as primary treatment for endometrioid tumors from January, 2000 to December, 2010...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28355107/pathology-of-aging-in-nod-scid-gamma-female-mice
#19
Sara F Santagostino, Rodolfo J Ricart Arbona, Melissa A Nashat, Julie R White, Sebastien Monette
In the past decade, NOD.Cg- Prkdc(scid) Il2rg(tm1Wjl)/SzJ (NSG, NOD scid gamma) mice have become a model of choice in several areas of biomedical research; however, comprehensive data on their spontaneous age-related pathology are not currently available in the literature. The prevalence of spontaneous morbidity affecting aged NSG female breeders enrolled in a parasitology study was documented with classification of neoplastic and non-neoplastic (inflammatory, metabolic, degenerative) lesions. Malignant mammary neoplasms were most commonly diagnosed, often accompanied by pulmonary metastases, while a low frequency of lymphoma and histiocytic sarcoma was documented...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28353387/recent-developments-in-surgical-pathology-of-the-uterine-corpus
#20
REVIEW
Krisztina Z Hanley, George G Birdsong, Marina B Mosunjac
There have been several updates recently on the classification of uterine tumors. Endometrial carcinomas have traditionally been divided into 2 types, but some are difficult to classify and do not fit readily into either of the currently recognized categories. The Cancer Genome Atlas Research Network has recently defined 4 new categories of endometrial cancer on the basis of mutational spectra, copy number alteration, and microsatellite instability, which might provide independent prognostic information beyond established risk factors...
April 2017: Archives of Pathology & Laboratory Medicine
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