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https://www.readbyqxmd.com/read/29775405/the-mouse-heart-attack-research-tool-mhart-1-0-database
#1
Kristine Y DeLeon-Pennell, Rugmani Padmanabhan Iyer, Yonggang Ma, Andriy Yabluchanskiy, Rogelio Zamilpa, Ying Ann Chiao, Presley Cannon, Courtney Cates, Elizabeth R Flynn, Ganesh V Halade, Lisandra E de Castro Bras, Merry L Lindsey
The generation of Big Data has enabled systems-level dissections into the mechanisms of cardiovascular pathology. Integration of genetic, proteomic, and pathophysiological variables across platforms and laboratories fosters discoveries through multidisciplinary investigations and minimizes unnecessary redundancy in research efforts. The Mouse Heart Attack Research Tool (mHART) consolidates a large dataset of over 10 years of experiments from a single laboratory for cardiovascular investigators to generate novel hypotheses and identify new predictive markers of progressive left ventricular remodeling following myocardial infarction (MI) in mice...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29773939/retinopathy-and-mortality
#2
Emily Frith, Paul D Loprinzi
Objective: We evaluated the specific association between retinopathy and all-cause mortality among a national sample of the broader U.S. adult population. Methods: Data from the 2005-2008 National Health and Nutrition Examination Survey were used to identify 4,777 adults with complete data regarding screening for nonproliferative retinopathy using Early Treatment Diabetic Retinopathy Study grading criteria, as well as objective retinal imaging assessments using the Canon Non-Mydriatic Retinal Camera CR6-45NM...
May 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29772570/undertreatment-of-vascular-risk-factors-in-patients-with-monocular-ischaemic-visual-loss
#3
Angeliki Zarkali, Suk Fun Cheng, Agnes Dados, Robert Simister, Arvind Chandratheva
BACKGROUND AND PURPOSE: Ischaemic visual loss is often considered a lower risk factor than other transient ischaemic attacks (TIA). We aimed to determine the recurrence risk, prevalence and management of vascular risk factors in these patients. METHODS: The study took place in the University College Hospital London daily TIA clinic, main referral centre for North-Central London and Moorfields Eye Hospital. Consecutive records for patients with transient (< 24 h) or permanent (> 24 h) ischaemic visual loss were reviewed during the period January 2014-October 2016...
May 17, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29767706/associations-between-vigorous-physical-activity-and-chronic-diseases-in-older-adults-a-study-in-13-european-countries
#4
Adilson Marques, Miguel Peralta, Hugo Sarmento, João Martins, Miguel González Valeiro
Background: This study aimed to assess cross-sectional and prospective relationships between vigorous physical activity (VPA) and the risk of major chronic diseases among European older adults. Methods: Participants were 37 524 older adults who responded to the fourth (in 2011) and fifth (in 2013) wave of the SHARE project, from 13 European countries. Participants answered interview questions about the presence of chronic conditions and VPA. The cross-sectional and prospective association between PA and the number of chronic diseases was assessed using logistic regression models...
May 14, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29759064/propolis-ethanolic-extracts-reduce-adenosine-diphosphate-induced-platelet-aggregation-determined-on-whole-blood
#5
Mirza Bojić, Andrea Antolić, Maja Tomičić, Željko Debeljak, Željan Maleš
BACKGROUND: Propolis is a well-known bee product containing more than 2000 identified compounds. It has many beneficial effects on human health that include antibacterial, antiviral, anticancer and hepatoprotective justifying its use as a dietary supplement. Platelet aggregation plays crucial role in thrombus formation that can cause stroke or heart attacks. As cardiovascular diseases, including those caused by thrombus formation, are related to 50% of deaths of Western population, the objective of this study was to determine antiaggregatory activity of propolis on platelet aggregation on the whole blood samples...
May 14, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29755162/bayesian-regression-model-for-recurrent-event-data-with-event-varying-covariate-effects-and-event-effect
#6
Li-An Lin, Sheng Luo, Barry R Davis
In the course of hypertension, cardiovascular disease events (e.g., stroke, heart failure) occur frequently and recurrently. The scientific interest in such study may lie in the estimation of treatment effect while accounting for the correlation among event times. The correlation among recurrent event times come from two sources: subject-specific heterogeneity (e.g., varied lifestyles, genetic variations, and other unmeasurable effects) and event dependence (i.e., event incidences may change the risk of future recurrent events)...
2018: Journal of Applied Statistics
https://www.readbyqxmd.com/read/29753188/risk-assessment-of-total-mercury-and-methylmercury-in-aquatic-products-from-offshore-farms-in-china
#7
Wei Zhang, Xue Zhang, Yuling Tian, Yan Zhu, Yindong Tong, Ying Li, Xuejun Wang
Contamination of methylmercury (MeHg) in aquatic products has been a wide spread health concern. The objective of this study is to determine total mercury (THg) and MeHg concentrations in different species of aquatic products from major offshore farms in China, and to assess health impacts from consumption. Results showed that the concentrations of THg and MeHg ranged 5.6-328.4 ng/g (wet weight) and 4.3-303.6 ng/g (wet weight) in aquatic products, respectively, and were very variable among species and origin sources...
April 26, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29752776/influence-of-prehospital-airway-management-on-neurological-outcome-in-patients-transferred-to-a-heart-attack-centre-following-out-of-hospital-cardiac-arrest
#8
Timothy Edwards, Julia Williams, Michaela Cottee
OBJECTIVE: To describe the association between prehospital airway management and neurological outcomes in patients transferred by the ambulance service directly to a heart attack centre (HAC) post-return of spontaneous circulation (ROSC). METHODS: A retrospective observational cohort study in which ambulance records were reviewed to determine prehospital airway management strategy and collect physiological and demographic data. HAC notes were obtained to determine in-hospital management and quantify neurological outcome via the cerebral performance category (CPC) scale...
May 11, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29747915/prognostic-and-practical-validation-of-current-definitions-of-myocardial-infarction-associated-with-percutaneous-coronary-intervention
#9
Pierluigi Tricoci, L Kristin Newby, Robert M Clare, Sergio Leonardi, C Michael Gibson, Robert P Giugliano, Paul W Armstrong, Frans Van de Werf, Gilles Montalescot, David J Moliterno, Claes Held, Philip E Aylward, Lars Wallentin, Robert A Harrington, Eugene Braunwald, Kenneth W Mahaffey, Harvey D White
OBJECTIVES: In 13,038 patients with non-ST-segment elevation acute coronary syndrome undergoing index percutaneous coronary intervention (PCI) in the EARLY ACS (Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Coronary Syndrome) and TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) trials, the relationship between PCI-related myocardial infarction (MI) and 1-year mortality was assessed. BACKGROUND: The definition of PCI-related MI is controversial...
May 14, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29747747/tiger-nut-and-walnut-extracts-modulate-extracellular-metabolism-of-atp-and-adenosine-through-the-nos-cgmp-pkg-signalling-pathway-in-kidney-slices
#10
Ayodeji A Olabiyi, Fabiano B Carvalho, Nathieli B Bottari, Vera M Morsch, Ademir F Morel, Ganiyu Oboh, Maria Rosa Schetinger
BACKGROUND: Tiger nut (Cyperus esculentus L.) and walnut (Tetracarpidium conophorum Müll. Arg.) have been reportedly used in the treatment of inflammatory diseases such as atherosclerosis, prevent heart attack and improve blood circulation, reduce serum cholesterol level as well as inhibit oxidation reactions. PURPOSE: This study investigated the effect of tiger nut and walnut hydro-alcoholic extracts on extracellular metabolism of ATP through the NOS/cGMP/PKG signaling pathway induced by Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) in kidney slices...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746650/age-dependent-morbidity-and-mortality-outcomes-after-surgical-aortic-valve-replacement
#11
Amjad I Hussain, Andreas Auensen, Cathrine Brunborg, Jan Otto Beitnes, Lars Gullestad, Kjell I Pettersen
OBJECTIVES: This study addressed the assumption of increased morbidity and mortality after surgical aortic valve replacement in patients older than 80 years with severe aortic stenosis. METHODS: This prospective study was performed in consecutive patients referred for aortic valve replacement. The age-dependent change in cognitive and physical function, quality of life and rehospitalization and complication rates during the following year and 5-year all-cause mortality were documented...
May 9, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29745996/how-do-anticoagulated-atrial-fibrillation-patients-who-suffer-ischemic-stroke-or-spontaneous-intracerebral-hemorrhage-differ
#12
Heidi Lehtola, Juha Hartikainen, Päivi Hartikainen, Tuomas Kiviniemi, Ilpo Nuotio, Antti Palomäki, Antti Ylitalo, K E Juhani Airaksinen, Pirjo Mustonen
BACKGROUND: Atrial fibrillation (AF) increases risk of ischemic stroke, and oral anticoagulation (OAC) increases risk of intracerebral hemorrhage (ICH). This study aimed to compare OAC-treated AF patients with an ischemic stroke/transient ischemic attack (TIA) or spontaneous ICH as their first lifetime cerebrovascular event, especially focusing on patients with therapeutic international normalized ratio (INR). HYPOTHESIS: We assumed that in AF patients suffering ischemic stroke/TIA or ICH, patient characteristics could be different in patients with therapeutic INR than in patients with warfarin...
May 10, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29741779/n1-methylnicotinamide-mnam-as-a-guardian-of-cardiovascular-system
#13
REVIEW
Hamid Reza Nejabati, Aynaz Mihanfar, Masoud Pezeshkian, Amir Fattahi, Zeinab Latifi, Naser Safaie, Mohammad Valiloo, Ahmad Reza Jodati, Mohammad Nouri
Atherosclerosis is identified as the formation of atherosclerotic plaques, which could initiate the formation of a blood clot in which its growth to coronary artery can lead to a heart attack. N-methyltransferase (NNMT) is an enzyme that converts the NAM (nicotinamide) to its methylated form, N1-methylnicotinamide (MNAM). Higher levels of MNAM have been reported in cases with coronary artery disease (CAD). Further, MNAM increases endothelial prostacyclin (PGI2) and nitric oxide (NO) and thereby causes vasorelaxation...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29740816/the-impact-of-the-hospital-readmissions-reduction-program-across-insurance-types-in-california
#14
David S Zingmond, Li-Jung Liang, Punam Parikh, José J Escarce
OBJECTIVE: Examine 30-day readmission rates for indicator conditions before and after adoption of the Hospital Readmissions Reduction Program (HRRP). DATA: California hospital discharge data, 2005 to 2014. STUDY DESIGN: Estimated difference between pre-HRRP trends and post-HRRP rates of hospital readmissions after hospitalization for indicator conditions targeted by the HRRP (heart attack, heart failure, and pneumonia) by payer among insured adults...
May 8, 2018: Health Services Research
https://www.readbyqxmd.com/read/29735474/the-detroit-young-adult-asthma-project-proposal-for-a-multicomponent-technology-intervention-for-african-american-emerging-adults-with-asthma
#15
Karen MacDonell, Sylvie Naar, Wanda Gibson-Scipio, Jean-Marie Bruzzese, Bo Wang, Aaron Brody
BACKGROUND: Racial and ethnic minority youth have poorer asthma status than white youth, even after controlling for socioeconomic variables. Proper use of asthma controller medications is critical in reducing asthma mortality and morbidity. The clinical consequences of poor asthma management include increased illness complications, excessive functional morbidity, and fatal asthma attacks. There are significant limitations in research on interventions to improve asthma management in racial minority populations, particularly minority adolescents and young adults, although illness management tends to deteriorate after adolescence during emerging adulthood, the unique developmental period beyond adolescence but before adulthood...
May 7, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29732223/comparison-of-the-clinical-efficacy-of-salbutamol-with-jet-and-mesh-nebulizers-in-asthmatic-children
#16
Norihide Murayama, Kikuno Murayama
Background: Ultrasonic, jet, and mesh nebulizers have all been used in the treatment for asthma. Mesh nebulizers reportedly offer the best inhalation efficiency. Methods: This study aimed to clarify the utility of the mesh nebulizer, compared to jet nebulizers, in the treatment of pediatric asthma patients. Participants included 88 children <6 years old who were receiving treatment for asthma at Murayama Pediatric Clinic. Heart rate, peripheral oxygen saturation in arterial blood, and Mitsui symptom scores were compared before and after treatment with a mesh nebulizer ( n = 43) or jet nebulizer ( n = 45) using a salbutamol inhalation solution (0...
2018: Pulmonary Medicine
https://www.readbyqxmd.com/read/29730481/age-threshold-for-proper-definition-of-premature-coronary-artery-disease-in-males
#17
REVIEW
Hasan A Abderrahman, Imad M Al-Abdallat, Ahmed K Idhair
BACKGROUND: There is no universally accepted definition for the cut point age before which atherosclerosis is considered "premature." This is a retrospective study aimed to utilize the medico legal autopsy information for finding a proper definition of the age threshold of premature atherosclerosis in males. OBJECTIVES: This work aimed to utilize autopsy reports data that were issued at Jordan University Hospital to evaluate age-related differences in the distribution of coronary atherosclerotic and myocardial lesions and the determination of the age threshold at which such differences became apparent in male deaths...
April 30, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29721002/should-atrial-fibrillation-patients-with-hypertension-as-an-additional-risk-factor-of-the-cha2ds2-vasc-score-receive-oral-anticoagulation
#18
REVIEW
Juan Wang, Da-Peng Zhang, Hong-Bin Liu, Jiu-Chang Zhong, Xin-Chun Yang
Hypertension has been found to be increased a risk of stroke in atrial fibrillation (AF). Both the European and U.S. guidelines advocate the use of the CHA2 DS2 -VASc (congestive heart failure, hypertension, age > 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category) scheme for risk stratification. Although vitamin K antagonists is more effective than acetylsalicylic acid at preventing ischaemic stroke, its benefit is offs by an increased haemorrhage risk...
March 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29716889/gp-who-sexually-assaulted-patient-who-thought-she-was-having-a-heart-attack-is-jailed-for-15-months
#19
Clare Dyer
No abstract text is available yet for this article.
May 1, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29715505/the-exceptional-sensitivity-of-brain-mitochondria-to-copper
#20
Sabine Borchard, Francesca Bork, Tamara Rieder, Carola Eberhagen, Bastian Popper, Josef Lichtmannegger, Sabine Schmitt, Jerzy Adamski, Martin Klingenspor, Karl-Heinz Weiss, Hans Zischka
Wilson disease (WD) is characterized by a disrupted copper homeostasis resulting in dramatically increased copper levels, mainly in liver and brain. While copper damage to mitochondria is an established feature in WD livers, much less is known about such detrimental copper effects in other organs. We therefore assessed the mitochondrial sensitivity to copper in a tissue specific manner, namely of isolated rat liver, kidney, heart, and brain mitochondria. Brain mitochondria presented with exceptional copper sensitivity, as evidenced by a comparatively early membrane potential loss, profound structural changes already at low copper dose, and a dose-dependent reduced capacity to produce ATP...
April 28, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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