Weimin Zhang, Qi Li, Yuchen Zhang, Zhiming Wang, Shushu Yuan, Xinyun Zhang, Meifang Zhao, Wenzhuo Zhuang, Bingzong Li
Ferroptosis, a nonapoptotic form of cell death marked by iron-dependent peroxidation of phospholipids, is associated with the occurrence and progression of tumors. Erastin, a selective inhibitor of the cystine/glutamate transporter system Xc- , can induce the ferroptosis of cancer cells. Multiple myeloma (MM) has been reported to be insensitive to erastin-induced ferroptosis. However, we found the erastin sensitivity of different MM cells varied widely. Specifically, SLC7A11 abundance determined the sensitivity of MM cells to erastin-induced ferroptosis...
November 24, 2023: Apoptosis: An International Journal on Programmed Cell Death