keyword
https://read.qxmd.com/read/38468526/increased-cyclic-adenosine-monophosphate-responsive-element-is-closely-associated-with-the-pathogenesis-of-drug-resistant-epilepsy
#1
JOURNAL ARTICLE
Jing-Xuan Li, Dai Shi, Si-Ying Ren, Guo-Feng Wu
BACKGROUND: Drug-resistant epilepsy (DRE) is a refractory neurological disorder. There is ample evidence that suggest that γ-aminobutyric acid-a (GABAA) receptors could be one of the mechanisms responsible for the development of drug resistance in epilepsy. It is also known that the cAMP response element binding protein (CREB) plays a possible key role in the transcriptional regulation of GABAA. OBJECTIVE: This study explores the role of CREB in the development of DRE and the effect of CREB on GABA-related receptors in DRE...
March 8, 2024: Current Neurovascular Research
https://read.qxmd.com/read/38446345/long-term-effect-of-multichannel-tdcs-protocol-in-patients-with-central-cortex-epilepsies-associated-with-epilepsia-partialis-continua
#2
JOURNAL ARTICLE
M Daoud, C Durelle, A Fierain, El Youssef N, F Wendling, G Ruffini, P Benquet, F Bartolomei
Epilepsia partialis continua (EPC) is a rare type of focal motor status epilepticus that causes continuous muscle jerking in a specific part of the body. Experiencing this type of seizure, along with other seizure types, such as focal motor seizures and focal to bilateral tonic-clonic seizures, can result in a disabling situation. Non-invasive brain stimulation methods like transcranial direct current stimulation (tDCS) show promise in reducing seizure frequency (SF) when medications are ineffective. However, research on tDCS for EPC and related seizures is limited...
March 6, 2024: Brain Topography
https://read.qxmd.com/read/38441162/status-epilepticus-what-s-new-for-the-intensivist
#3
JOURNAL ARTICLE
Sarah Benghanem, Estelle Pruvost Robieux, Aidan Neligan, Matthew C Walker
PURPOSE OF REVIEW: Status epilepticus (SE) is a common neurologic emergency affecting about 36.1/100 000 person-years that frequently requires intensive care unit (ICU) admission. There have been advances in our understanding of epidemiology, pathophysiology, and EEG monitoring of SE, and there have been large-scale treatment trials, discussed in this review. RECENT FINDINGS: Recent changes in the definitions of SE have helped guide management protocols and we have much better predictors of outcome...
February 14, 2024: Current Opinion in Critical Care
https://read.qxmd.com/read/38406728/anti-epileptic-drug-aed-loading-in-status-epilepticus-an-audit-and-introduction-of-levetiracetam-loading-protocol
#4
JOURNAL ARTICLE
Jessie Gew
No abstract text is available yet for this article.
November 2023: Future Healthcare Journal
https://read.qxmd.com/read/38384587/inhaled-volatiles-for-status-asthmaticus-epilepsy-and-difficult-sedation-in-adult-icu-and-picu-a-systematic-review
#5
REVIEW
Kevin Gorsky, Sean Cuninghame, Kesikan Jayaraj, Marat Slessarev, Conall Francoeur, Davinia E Withington, Jennifer Chen, Brian H Cuthbertson, Claudio Martin, Martin Chapman, Saptharishi Lalgudi Ganesan, Nicole McKinnon, Angela Jerath
OBJECTIVES: Inhaled volatile anesthetics support management of status asthmaticus (SA), status epilepticus (SE), and difficult sedation (DS). This study aimed to evaluate the effectiveness, safety, and feasibility of using inhaled anesthetics for SA, SE, and DS in adult ICU and PICU patients. DATA SOURCES: MEDLINE, Cochrane Central Register of Controlled Trials, and Embase. STUDY SELECTION: Primary literature search that reported the use of inhaled anesthetics in ventilated patients with SA, SE, and DS from 1970 to 2021...
February 2024: Critical care explorations
https://read.qxmd.com/read/38142368/picu-admission-of-children-for-status-epilepticus-is-there-a-different-approach-between-referral-and-second-level-hospitals-in-an-italian-region
#6
JOURNAL ARTICLE
Claudia Maria Bonardi, Margherita Nosadini, Giulia Lorenzoni, Anna Tessari, Lorenza Santoro, Andrea Pettenazzo, Dario Gregori, Stefano Sartori, Angela Amigoni
Appropriate status epilepticus (SE) management is key to minimize admission to the pediatric intensive care unit (PICU). We retrospectively describe 115 children admitted to the PICU of the tertiary-care referral hospital of Padova for seizures, SE, and SE-related complications (59% from second-level hospitals, 41% from the referral hospital) and compare SE management among hospitals. Compared with the referral center, in second-level hospitals, anesthetics were more often administered as first/second drug ( P < ...
December 24, 2023: Clinical Pediatrics
https://read.qxmd.com/read/37972419/external-validation-of-newly-modified-status-epilepticus-severity-score-for-predicting-mortality-in-patients-with-status-epilepticus-in-a-regional-hospital-in-taiwan
#7
JOURNAL ARTICLE
Tzu-Hsin Huang, Tsang-Shan Chen, Chin-Wei Huang
PURPOSE: To evaluate and compare the performance of the status epilepticus severity score (STESS), modified STESS (mSTESS), and the newly modified STESS (nSTESS) in predicting mortality in patients with status epilepticus (SE) at a regional hospital in Taiwan. METHODS: Data were collected from 81 patients with SE, aged over 18 years at a regional medical hospital in Tainan from January 2012 to December 2022. SE were treated following the standard treatment protocol...
November 14, 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/37941351/electroencephalography-prediction-of-neurological-outcomes-after-hypoxic-ischemic-brain-injury-a-systematic-review-and-meta-analysis
#8
JOURNAL ARTICLE
Xina Ding, Zhixiao Shen
Background. Predicting neurological outcomes after hypoxic-ischemic brain injury (HIBI) is difficult. Objective. Electroencephalography (EEG) can identify acute and subacute brain abnormalities after hypoxic brain injury and predict HIBI recovery. We examined EEG's ability to predict neurologic outcomes following HIBI. Method. A PRISMA-compliant search was conducted in the Medline, Embase, Cochrane, and Central databases until January 2023. EEG-predicted neurological outcomes in HIBI patients were selected from relevant perspective and retrospective cohort studies...
November 8, 2023: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://read.qxmd.com/read/37855691/non-convulsive-status-epilepticus-versus-periodic-eeg-pattern-in-sporadic-creutzfeldt-jakob-disease-two-sides-of-the-same-coin
#9
JOURNAL ARTICLE
Martina Fanella, Giada Valente, Laura Borrello, Fabiana Marinelli, Martina Bracaglia, Ottavio Di Marco, Filippo Costanzo, Fabrizio Apponi, Roberto De Simone
Sporadic Creutzfeldt-Jakob disease is characterized by rapid cognitive and neuropsychiatric impairment. The Heidenhain variant of Creutzfeldt-Jakob disease is known for isolated visual disturbance that precedes other features. Periodic sharp wave complexes on EEG are typical of sporadic Creutzfeldt-Jakob disease, but at the onset, the electroclinical pattern may be unclear and suggest the hypothesis of a non-convulsive status epilepticus. Furthermore, non-convulsive status epilepticus and sporadic Creutzfeldt-Jakob disease could coexist simultaneously...
October 19, 2023: International Journal of Neuroscience
https://read.qxmd.com/read/37793283/differential-impact-of-a-ghrelin-receptor-antagonist-or-inverse-agonist-in-the-electrical-kindling-model-of-epilepsy
#10
JOURNAL ARTICLE
Siamak Beheshti, Shiva Ershadi, Fatemeh Zamani, Mansour Azimzadeh, Mohammad Wasil Wesal
Ghrelin is a peptide, which has been shown to affect seizures. However, there is not a consensus about its real impact on the control of seizure severity. We assessed the influence of intra-amygdala injections of a ghrelin receptor (GHSR) antagonist, as well as a GHSR inverse agonist on the electrical kindling-induced seizures. Two unipolar electrodes and a tripolar electrode twisted with a guide cannula were implanted in the skull surface or the basolateral amygdala of adult male rats, respectively. A rapid electrical kindling protocol was applied for kindling epileptogenesis...
September 30, 2023: Epilepsy Research
https://read.qxmd.com/read/37750463/dravet-syndrome-a-systematic-literature-review-of-the-illness-burden
#11
REVIEW
Adam Strzelczyk, Lieven Lagae, Jo M Wilmshurst, Andreas Brunklaus, Pasquale Striano, Felix Rosenow, Susanne Schubert-Bast
We performed a systematic literature review and narrative synthesis according to a pre-registered protocol (Prospero: CRD42022376561) to identify the evidence associated with the burden of illness in Dravet syndrome (DS), a developmental and epileptic encephalopathy characterized by drug-resistant epilepsy with neurocognitive and neurobehavioral impairment. We searched MEDLINE, Embase, and APA PsychInfo, Cochrane's database of systematic reviews, and Epistemonikos from inception to June 2022. Non-interventional studies reporting on epidemiology (incidence, prevalence, and mortality), patient and caregiver health-related quality of life (HRQoL), direct and indirect costs and healthcare resource utilization were eligible...
September 26, 2023: Epilepsia Open
https://read.qxmd.com/read/37732629/association-of-seizure-with-covid-19-vaccines-in-persons-with-epilepsy-a-systematic-review-and-meta-analysis
#12
REVIEW
Ali Rafati, Melika Jameie, Mobina Amanollahi, Mana Jameie, Yeganeh Pasebani, Delaram Sakhaei, Saba Ilkhani, Sina Rashedi, Mohammad Yazdan Pasebani, Mohammadreza Azadi, Mehran Rahimlou, Churl-Su Kwon
Seizure aggravation following coronavirus disease 2019 (COVID-19) vaccines is a major cause behind vaccine hesitancy among persons with epilepsy (PwE), resulting in lower immunization rates. We systematically reviewed seizure-activity-related events in PwE following COVID-19 vaccination. We systematically searched PubMed, Web of Science, Scopus, and Cochrane Library, until January 31, 2023, and included articles reporting seizure activity-related events in PwE receiving COVID-19 vaccination. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses were followed...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37717459/predicting-seizure-clustering-in-the-epilepsy-monitoring-unit-a-multivariable-analysis
#13
JOURNAL ARTICLE
Leya Maliekal, Deepti Zutshi, Scott Millis, Maysaa M Basha
INTRODUCTION: Seizure clustering, is the most frequently reported adverse event in epilepsy monitoring unit (EMU) safety studies which, can also potentiate other adverse events, such as falls, status epilepticus, and increased length of stay. The purpose of this study is to determine variables associated with increased risk of seizure clustering among patients admitted to the EMU. METHODS: A retrospective review of patients admitted to the EMU over a two-year period was completed...
September 15, 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/37715318/sex-and-gonadectomy-modify-behavioral-seizure-susceptibility-and-mortality-in-a-repeated-low-dose-kainic-acid-systemic-injection-paradigm-in-mice
#14
JOURNAL ARTICLE
Niraj V Lawande, Elisabeth A Conklin, Catherine A Christian-Hinman
OBJECTIVE: Sex differences in epilepsy appear driven in part due to effects of gonadal steroids, with varying results in experimental models based on species, strain, and method of seizure induction. Furthermore, removing a main source of these steroids via gonadectomy may impact seizure characteristics differently in males and females. Repeated low-dose kainic acid (RLDKA) systemic injection paradigms were recently shown to reliably induce status epilepticus (SE) and hippocampal histopathology in C57BL/6J mice...
September 15, 2023: Epilepsia Open
https://read.qxmd.com/read/37675074/duration-of-constant-rate-infusion-with-diazepam-or-propofol-for-canine-cluster-seizures-and-status-epilepticus
#15
JOURNAL ARTICLE
Giulia Cagnotti, Sara Ferrini, Giorgia Di Muro, Eleonora Avilii, Alessandra Favole, Antonio D'Angelo
INTRODUCTION: Constant rate infusion (CRI) of benzodiazepines or propofol (PPF) is a therapeutic option for cluster seizures (CS) and status epilepticus (SE) in canine patients non-responding to first-line benzodiazepines or non-anesthetics. However, specific indications for optimal duration of CRI are lacking. The aim of this study was to determine the effect of duration of anesthetic CRI on outcome and length of hospital stay in dogs with refractory seizure activity of different etiology...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37624689/continuous-electroencephalography-eeg-protocol-improves-seizure-detection-in-children-on-extracorporeal-membrane-oxygenation
#16
JOURNAL ARTICLE
Danielle deCampo, Khalil S Husari, Melania M Bembea, Christa W Habela, Eva K Ritzl
BACKGROUND / OBJECTIVE: Seizures are a complication for pediatric patients requiring extracorporeal membrane oxygenation (ECMO). There are no standardized guidelines regarding continuous electroencephalography (EEG) monitoring to detect seizures in these patients, and the impact of protocolized monitoring has not been evaluated. Here we examined the effects of continuous EEG protocol implementation in our pediatric ECMO population. METHODS: Retrospective chart reviews were conducted on 57 patients who underwent extracorporeal membrane oxygenation and concurrent continuous EEG out of 165 patients supported on extracorporeal membrane oxygenation...
October 2023: Journal of Child Neurology
https://read.qxmd.com/read/37572532/alice-in-wonderland-syndrome-through-the-looking-glass-in-a-rare-presentation-of-non-convulsive-status-epilepticus-in-cerebral-venous-sinus-thrombosis-and-covid-19
#17
M Biggi, M Contento, M Magliani, G Giovannelli, A Barilaro, V Bessi, I Lombardo, L Massacesi, E Rosati
Alice in Wonderland Syndrome (AIWS) is a rare perceptual disorder, rarely associated with epileptic etiology. We report the case of a 23-year-old man with subacute onset of right peri-orbital headache and visual misperceptions consistent with AIWS Type B, who underwent laboratory tests, brain CT with venography, ophthalmic examination, and neurological assessment that turned out to be normal except for visuospatial difficulties and constructional apraxia. A nasopharyngeal SARS-CoV2 swab taken as screening protocol was positive...
July 24, 2023: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://read.qxmd.com/read/37497016/safety-and-efficacy-of-rapid-withdrawal-of-anti-seizure-medication-during-long-term-video-eeg-monitoring
#18
JOURNAL ARTICLE
Jiao Liu, Deng Chen, Yingchun Xu, Yu Zhang, Ling Liu
OBJECTIVE: Anti-seizure medications (ASMs) are often withdrawn during long-term video-EEG monitoring (LTM) to allow pre-surgical evaluation. Herein, we evaluated the safety and efficacy of ultra-rapid withdrawal (URW) and rapid withdrawal (RW) of ASMs in an epilepsy monitoring unit (EMU). METHODS: This retrospective study examined all consecutive patients admitted to our EMU between May 2021 and October 2022. Patients were classified into the URW and RW groups according to the way ASMs were withdrawn...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37467703/lestaurtinib-cep-701-reduces-the-duration-of-limbic-status-epilepticus-in-periadolescent-rats
#19
JOURNAL ARTICLE
Yara Mrad, Reem El Jammal, Helene Hajjar, Sana Alturk, Houssein Salah, Hiba-Douja Chehade, Fatima Dandash, Zahraa Mallah, Firas Kobeissy, Aida Habib, Eva Hamade, Makram Obeid
BACKGROUND: The timely abortion of status epilepticus (SE) is essential to avoid brain damage and long-term neurodevelopmental sequalae. However, available anti-seizure treatments fail to abort SE in 30% of children. Given the role of the tropomyosin-related kinase B (TrkB) receptor in hyperexcitability, we investigated if TrkB blockade with lestaurtinib (CEP-701) enhances the response of SE to a standard treatment protocol and reduces SE-related brain injury. METHODS: SE was induced with intra-amygdalar kainic acid in postnatal day 45 rats under continuous electroencephalogram (EEG)...
July 14, 2023: Epilepsy Research
https://read.qxmd.com/read/37460236/pearls-oy-sters-whole-genome-sequencing-in-critically-ill-neurologic-patient-leads-to-diagnosis-with-treatment-implications
#20
JOURNAL ARTICLE
Jonathan Read Gaillard, Zachary Whitt, Linda M Selwa, David Harris, Kristen N Lee
Many adult patients with a history of seizures and global developmental delay do not have an identified etiology for their epilepsy. Rapid whole-genome sequencing (rWGS) can be used to identify a genetic etiology in critically ill patients to provide actionable interventions. In this case, a 27-year-old patient with a history of epilepsy, global developmental delay, and intellectual disability presented with altered mental status and new abnormal movements. The patient acutely declined over the course of 24-48 hours of presentation, including nonconvulsive status epilepticus leading to intubation for airway protection, 2 episodes of ventricular tachycardia requiring synchronized cardioversion, and 1 episode of supraventricular tachycardia...
September 26, 2023: Neurology
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