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https://www.readbyqxmd.com/read/29904600/refinement-of-a-mouse-cardiovascular-model-development-application-and-dissemination
#1
REVIEW
Kirk A Taylor, Michael Emerson
European and UK legislation requires all animal procedures to be conducted with consideration to reduction, refinement and replacement. In this review, 3Rs developments are discussed in the field of platelet biology and thromboembolism. Platelet research requires the use of animal models, and mice are widely used in the field. When working in vitro , conventional light transmission techniques have been scaled down allowing reduction in animal numbers. In vivo , vascular injury models are widely used and work is ongoing to develop ex vivo approaches that use fewer animals...
2018: F1000Research
https://www.readbyqxmd.com/read/29880651/shifting-understandings-of-labour-pain-in-canadian-medical-history
#2
Whitney Wood
While pain in childbirth is a universal, cross-cultural, biological reality, individual experiences and perceptions of this pain are historically and culturally specific. At the turn of the 20th century-a key period in terms of both the medicalisation of birth and the professionalisation of obstetrics in the Canadian context-Canadian physicians understood and conceptualised 'birth pangs' in a number of varying (and at times competing) ways. Throughout the 19th century, doctors emphasised the broader utility of pain as a diagnostic tool and a physiologically necessary part of the birthing process...
June 7, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29880162/comparison-of-local-and-intra-venous-dexamethasone-on-post-operative-pain-and-recovery-after-caeseream-section-a-randomized-controlled-trial
#3
Ahmed M Maged, Wesam Sayed Deeb, Sahar Elbaradie, Ahmed R Elzayat, Ahmed A Metwally, Mohamed Hamed, Ahmed Shaker
OBJECTIVE: To compare the effect of local infiltration and intravenous dexamethasone on postoperative pain and recovery after Cesarean Section (CS). MATERIAL AND METHODS: A Prospective, randomized study conducted on 120 pregnant women attending the labor wards. All participants were scheduled for elective CS under spinal anaesthesia and were randomly divided into 3 equal groups. Group 1 received 16 mg Dexamethasone IV drip. Group II received 16 mg Dexamethasone subcutaneous injection around the caesarean section scar after skin closure and Group III received Placebo (500 cc saline infusion)...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29875913/-peculiarities-of-anesthesia-for-the-surgical-treatment-of-pheochromocytoma-about-a-case
#4
Amadou Magagi, Harissou Adamou, Ibrahim Amadou Magagi, Maazou Halidou, Oumarou Habou, Hassane Moussa Diongolé, Maman Sani Rabiou, Mahaman Boukari Baoua
This study decribes the treatment of a 37-year old female patient, with a history of poorly treated arterial hypertension (AH), referred to surgical consultation with right lower back pain, vertigo, headache, sweating and palpitations. During hospitalization, blood pressure (BP) ranged between 130/80 mm Hg and 190/120 mm Hg. The remainder of the clinical examination was normal. Thoracoabdominal scanner showed adrenal mass measuring 55x45x65 mm compressing the inferior vena cava and the right renal vein. The assay of urinary vanilmandelic acid (VMA) was 11...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29871567/pain-and-outcomes-of-carpal-tunnel-release-under-local-anaesthetic-with-or-without-a-tourniquet-a-randomized-controlled-trial
#5
Hafiz J Iqbal, Ashtin Doorgakant, Nader N T Rehmatullah, Ashok L Ramavath, Prasad Pidikiti, Stephen Lipscombe
We conducted a prospective randomized controlled trial to investigate carpal tunnel decompression under local anaesthesia. Carpal tunnel decompression was performed in 37 wrists using local anaesthesia and an arm tourniquet and 36 without tourniquet but with a local anaesthetic mixture containing adrenaline. Patients who underwent carpal tunnel decompression using a tourniquet experienced a significantly greater degree of pain when compared with those who did not have a tourniquet. Pain and hand function improved to a similar degree in both groups...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29864216/continuous-intravenous-perioperative-lidocaine-infusion-for-postoperative-pain-and-recovery-in-adults
#6
REVIEW
Stephanie Weibel, Yvonne Jelting, Nathan L Pace, Antonia Helf, Leopold Hj Eberhart, Klaus Hahnenkamp, Markus W Hollmann, Daniel M Poepping, Alexander Schnabel, Peter Kranke
BACKGROUND: The management of postoperative pain and recovery is still unsatisfactory in a number of cases in clinical practice. Opioids used for postoperative analgesia are frequently associated with adverse effects, including nausea and constipation, preventing smooth postoperative recovery. Not all patients are suitable for, and benefit from, epidural analgesia that is used to improve postoperative recovery. The non-opioid, lidocaine, was investigated in several studies for its use in multimodal management strategies to reduce postoperative pain and enhance recovery...
June 4, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29851309/description-of-a-new-approach-for-great-auricular-and-auriculotemporal-nerve-blocks-a-cadaveric-study-in-foxes-and-dogs
#7
Thaleia-Rengina Stathopoulou, Rui Pinelas, Gert Ter Haar, Ine Cornelis, Jaime Viscasillas
Otitis externa is a painful condition that may require surgical intervention in dogs. A balanced analgesia protocol should combine systemic analgesic agents and local anaesthesia techniques. The aim of the study was to find anatomical landmarks for the great auricular and the auriculotemporal nerves that transmit nociceptive information from the ear pinna and to develop the optimal technique for a nerve block. The study consisted of two phases. In phase I, one fox cadaver was used for dissection and anatomical localization of the auricular nerves to derive landmarks for needle insertion...
May 2018: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29851190/choosing-wisely-in-pediatric-anesthesia-an-interpretation-from-the-german-scientific-working-group-of-paediatric-anaesthesia-wakka
#8
Karin Becke, Christoph Eich, Claudia Höhne, Martin Jöhr, Andreas Machotta, Markus Schreiber, Robert Sümpelmann
Inspired by the Choosing Wisely initiative, a group of pediatric anesthesiologists representing the German Working Group on Paediatric Anaesthesia (WAKKA) coined and agreed upon 10 concise positive ("dos") or negative ("don'ts") evidence-based recommendations. (i) In infants and children with robust indications for surgical, interventional, or diagnostic procedures, anesthesia or sedation should not be avoided or delayed due to the potential neurotoxicity associated with the exposure to anesthetics...
May 30, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29847969/postdural-puncture-headache-and-epidural-blood-patch-in-a-large-obstetric-anaesthesia-population
#9
Blanca Martínez, Enrique Canser, Alberto Alonso, Eduardo Alonso, Elena Gredilla, Jesús Díez, Fernando Gilsanz
OBJECTIVE: Postdural puncture headache (PDPH) is the most common serious complication in obstetric anesthesia. We show the incidence of accidental dural puncture (ADP), PDPH, epidural blood patch (EBP) and associated morbidity following a protocol established in an obstetric anesthesia department. METHODS: An observational, prospective, analytical study performed in 66,540 epidural labor analgesia procedures. The objective is to describe the incidence of ADP, PDPH and EBP in a large obstetric anesthesia population, as well as morbidity associated with ADP and EBP...
March 2018: Asian Journal of Anesthesiology
https://www.readbyqxmd.com/read/29808147/thyroid-cartilage-window-approach-to-extract-a-foreign-body-after-migration-into-the-paraglottic-space
#10
Sheikha Alkhudher, Faisal AlObaid, Shabreez Shafi
We report a case of fish bone impaction in the paraglottic space, which caused palsy of the left vocal cord. The patient was a 45-year-old man. He presented with throat pain and hoarseness of voice for approximately one week. The diagnosis was made after careful history taking and confirmed by the use of computed tomography scan as the fish bone was not visible endoscopically under local and general anaesthesia. The patient underwent thyroid cartilage window approach, and the fish bone was retrieved. His symptoms have improved significantly, and he did not require tracheostomy...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29802933/dibucaine-in-ionic-gradient-liposomes-biophysical-toxicological-and-activity-characterisation
#11
Veronica M Couto, Maria J Prieto, Daniela E Igartúa, Daniela A Feas, Lígia N M Ribeiro, Camila M G Silva, Simone R Castro, Viviane A Guilherme, Darlene D Dantzger, Daisy Machado, Silvia Del V Alonso, Eneida de Paula
Administration of local anaesthetics (LA) is one of the most effective pain control techniques for postoperative analgesia. However, anaesthetic agents easily diffuse into the injection site, limiting the time of anaesthesia. One approach to prolong analgesia is to entrap LA in nanostructured carriers (e.g. liposomes). Here we report that using an ammonium sulphate gradient was the best strategy to improve the encapsulation (62.6%) of dibucaine (DBC) into liposomes. Light scattering and nanotracking analyses were used to characterise vesicle properties, such as, size, polydispersity, zeta potentials and number...
May 23, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29797704/the-analgesic-effect-of-a-popliteal-plexus-blockade-after-total-knee-arthroplasty-a-feasibility-study
#12
C Runge, S Bjørn, J M Jensen, N D Nielsen, M Vase, C Holm, T F Bendtsen
INTRODUCTION: An obturator nerve block (ONB) and a femoral triangle block (FTB) provide effective analgesia after total knee arthroplasty (TKA) without impeding the ambulation, although the ONB produces motor blockade of the hip adductor muscles. The popliteal plexus (PP) in the popliteal fossa is formed by contribution from the tibial nerve and the posterior obturator nerve, innervating intraarticular genicular structures and the posterior capsule of the knee. We hypothesised that a popliteal plexus block (PPB) as a supplement to an FTB would reduce pain after TKA without anaesthetising motor branches from the sciatic nerve in the popliteal fossa...
May 24, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29794563/ultrasound-guided-single-injection-versus-continuous-sciatic-nerve-blockade-on-pain-management-and-mobilisation-after-total-knee-arthroplasty-cosinus-trial-a-randomised-triple-blinded-controlled-trial
#13
Thomas Wiesmann, Ivo Hüttemann, Nora Schilke, Thomas Heyse, Turgay Efe, Daphne Eschbach, Hinnerk Wulf, Thorsten Steinfeldt, Carsten Feldmann
BACKGROUND: Combining continuous femoral nerve blockade with single injection sciatic nerve blockade is standard peripheral nerve block practice for total knee arthroplasty (TKA) during the first 24 postoperative hours. OBJECTIVES: To assess the analgesic benefits and mobilisation capability of continuous sciatic blockade in conjunction with continuous femoral nerve blockade for 72 h after arthroplasty. DESIGN: Randomised, triple-blinded controlled trial...
May 21, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29794308/reducing-risk-of-spinal-haematoma-from-spinal-and-epidural-pain-procedures
#14
Harald Breivik, Hilde Norum, Christian Fenger-Eriksen, Seppo Alahuhta, Gísli Vigfússon, Owain Thomas, Michael Lagerkranser
BACKGROUND AND AIMS: Central neuraxial blocks (CNB: epidural, spinal and their combinations) and other spinal pain procedures can cause serious harm to the spinal cord in patients on antihaemostatic drugs or who have other risk-factors for bleeding in the spinal canal. The purpose of this narrative review is to provide a practise advisory on how to reduce risk of spinal cord injury from spinal haematoma (SH) during CNBs and other spinal pain procedures. Scandinavian guidelines from 2010 are part of the background for this practise advisory...
April 25, 2018: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29793602/systematic-review-of-the-effects-of-fascia-iliaca-compartment-block-on-hip-fracture-patients-before-operation
#15
REVIEW
J Steenberg, A M Møller
BACKGROUND: Fascia iliaca compartment block is used for hip fractures in order to reduce pain, the need for systemic analgesia, and prevent delirium, on this basis. This systematic review was conducted to investigate the analgesic and adverse effects of fascia iliaca block on hip fracture in adults when applied before operation. METHODS: Nine databases were searched from inception until July 2016 yielding 11 randomised and quasi-randomised controlled trials, all using loss of resistance fascia iliaca compartment block, with a total population of 1062 patients...
June 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29793431/anaesthesia-for-chest-wall-reconstruction-in-a-patient-with-poland-syndrome-care-compliant-case-report-and-literature-review
#16
Lingli Gui, Shiqian Shen, Wei Mei
BACKGROUND: Poland syndrome is a rare congenital disease, characterized by agenesis/hypoplasia of the pectoralis major muscle, usually associated with variable thoracic anomalies that needed chest wall reconstruction under general anesthesia. Anaesthetic management in Poland syndrome has scarcely been described. CASE PRESENTATION: Here, we present our anaesthetic management of Nuss procedure for chest wall correction in a 5 years old patient with Poland syndrome...
May 24, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29790159/development-of-a-new-analgesic-index-using-nasal-photoplethysmography
#17
B M Choi, C Park, Y H Lee, H Shin, S H Lee, S Jeong, G J Noh, B Lee
Although surrogate measures to quantify pain intensity have been commercialised, there is a need to develop a new index with improved accuracy. The aim of this study was to develop a new analgesic index using nasal photoplethysmography data. The specially designed sensor was placed between the columella and the nasal septum to acquire nasal photoplethysmography in surgical patients. Nasal photoplethysmography and Surgical Pleth Index® (GE Healthcare) data were obtained for 14 min both in the absence (pre-operatively) or presence (postoperatively) of pain in a group of surgical patients, each patient acting as their own control...
May 23, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29789137/serratus-intercostal-interfascial-block-as-an-opioid-saving-strategy-in-supra-umbilical-open-surgery
#18
M T Fernández Martín, S López Álvarez, M A Pérez Herrero
INTRODUCTION: The administration of local anaesthetic in the serratus-intercostal space provides adequate analgesia in non-reconstructive breast surgery. The aim of this study was to evaluate whether the blockage of the last intercostal nerves (T7-T11) can lead to opioid savings in supra-umbilical open surgery procedures. MATERIAL AND METHODS: A prospective observational study was conducted on patients undergoing open supra-umbilical surgery under general anaesthesia and with a serratus-intercostal plane block [modified Blocking the bRanches of IntercostaL nerves in the Middle Axillary line (BRILMA)] as an associated analgesic strategy...
May 19, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29787611/evaluation-of-anaesthetic-protocols-for-laboratory-adult-zebrafish-danio-rerio
#19
Tânia Martins, Enoque Diniz, Luís M Félix, Luís Antunes
In the last decades, the use of zebrafish (Danio rerio) in biomedical research has increased. Anaesthesia is daily used in fish during experimental procedures to avoid discomfort, stress or pain. Also, fish welfare and the reliability of results can be compromised if an unsuitable anaesthetic protocol is used. Therefore, we aimed to refine anaesthetic protocols to be used in adult zebrafish by evaluating the efficacy of different anaesthetics, used alone or in combination. For that, zebrafish were randomly assigned to 8 different groups: 100 μg/mLMS-222 (MS); 0...
2018: PloS One
https://www.readbyqxmd.com/read/29781530/a-comparison-between-methadone-and-buprenorphine-for-perioperative-analgesia-in-dogs-undergoing-ovariohysterectomy
#20
M D Shah, D Yates, J Hunt, J C Murrell
OBJECTIVE: To investigate whether preoperative methadone provides superior perioperative analgesia compared to buprenorphine in dogs undergoing ovariohysterectomy. METHODS: Eighty female dogs were recruited to an assessor-blinded, randomised, clinical trial. Dogs received a premedication dose of 0·05 mg/kg acepromazine or 10 μg/kg medetomidine combined with either 0·3 mg/kg methadone or 20 μg/kg buprenorphine intramuscularly. Anaesthesia was induced with propofol and maintained with isoflurane...
May 21, 2018: Journal of Small Animal Practice
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