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https://www.readbyqxmd.com/read/29164052/development-of-novel-patient-derived-xenografts-from-breast-cancer-brain-metastases
#1
María J Contreras-Zárate, D Ryan Ormond, Austin E Gillen, Colton Hanna, Nicole L Day, Natalie J Serkova, Britta M Jacobsen, Susan M Edgerton, Ann D Thor, Virginia F Borges, Kevin O Lillehei, Michael W Graner, Peter Kabos, Diana M Cittelly
Brain metastases are an increasing burden among breast cancer patients, particularly for those with HER2(+) and triple negative (TN) subtypes. Mechanistic insight into the pathophysiology of brain metastases and preclinical validation of therapies has relied almost exclusively on intracardiac injection of brain-homing cells derived from highly aggressive TN MDA-MB-231 and HER2(+) BT474 breast cancer cell lines. Yet, these well characterized models are far from representing the tumor heterogeneity observed clinically and, due to their fast progression in vivo, their suitability to validate therapies for established brain metastasis remains limited...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29143346/a-comparative-view-on-the-potential-acting-on-an-electron-in-a-molecule-and-the-electrostatic-potential-through-the-typical-halogen-bonds
#2
Ekaterina Bartashevich, Vladimir Tsirelson
This work considers the features of the electrostatic potential (ESP), and the potential acting on an electron in a molecule (PAEM) for the series of isolated dihalide molecules and for their molecular complexes. The joint analysis of these functions enriches the vision of atomic predispositions to the halogen bond formation and reveals details for their characterization. The account for the exchange-correlation interaction in PAEM retains the specific anisotropy of the ESP, which is commonly used for the halogen bonding explanation within σ-hole concept...
November 15, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29136298/tuning-the-f%C3%A3-rster-resonance-energy-transfer-through-self-assembly-approach-for-efficient-white-light-emission-in-aqueous-medium
#3
Pragyan Pallavi, Bahadur Sk, Palak Ahir, Abhijit Patra
A simple and cost-effective methodology employing environmentally benign substances for the fabrication of white-light emitting materials is important for practical applications in the field of lighting and display devices. Designing of purely organic-based white-light emitting system with high quantum efficiency in the aqueous medium is an unmet challenge. With this objective, a new class of pyridoindole based hydrophobic fluorophore 6,7,8,9-tetrapropylpyrido[1,2-a]indole-10-carbaldehye (TPIC) was introduced...
November 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29117787/reprogramming-of-adult-peripheral-blood-cells-into-human-induced-pluripotent-stem-cells-as-a-safe-and-accessible-source-of-endothelial-cells
#4
Pavel Simara, Lenka Tesarova, Daniela Rehakova, Simon Farkas, Barbara Salingova, Katerina Kutalkova, Eva Vavreckova, Pavel Matula, Petr Matula, Lenka Veverkova, Irena Koutna
New approaches in regenerative medicine and vasculogenesis have generated a demand for sufficient numbers of human endothelial cells (ECs). ECs and their progenitors (EPCs) reside on the interior surface of blood and lymphatic vessels or circulate in peripheral blood; however, their numbers are limited and they are difficult to expand after isolation. Recent advances in human induced pluripotent stem cell (hiPSC) research have opened possible avenues to generate unlimited numbers of ECs from easily accessible cell sources, such as the peripheral blood...
November 8, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29109416/mixed-quantum-dot-solar-cells
#5
Zhenyu Yang, James Z Fan, Andrew H Proppe, F Pelayo García de Arquer, David Rossouw, Oleksandr Voznyy, Xinzheng Lan, Min Liu, Grant Walters, Rafael Quintero-Bermudez, Bin Sun, Sjoerd Hoogland, Gianluigi A Botton, Shana O Kelley, Edward H Sargent
Colloidal quantum dots are emerging solution-processed materials for large-scale and low-cost photovoltaics. The recent advent of quantum dot inks has overcome the prior need for solid-state exchanges that previously added cost, complexity, and morphological disruption to the quantum dot solid. Unfortunately, these inks remain limited by the photocarrier diffusion length. Here we devise a strategy based on n- and p-type ligands that judiciously shifts the quantum dot band alignment. It leads to ink-based materials that retain the independent surface functionalization of quantum dots, and it creates distinguishable donor and acceptor domains for bulk heterojunctions...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29096373/distribution-recovery-and-concentration-of-platelets-and-leukocytes-in-l-prp-prepared-by-centrifugation
#6
Bruna Alice Gomes de Melo, Andréa Arruda Martins Shimojo, Amanda Gomes Marcelino Perez, José Fabio Santos Duarte Lana, Maria Helena Andrade Santana
Platelet-rich plasma (PRP) is an autologous product prepared from whole blood (WB) that is widely used in regenerative medicine. In clinical practice, discontinuous centrifugation is used for both hand- and machine-prepared PRP. However, separation of WB fractions via centrifugation is a complex process, and the lack of clear mechanisms limits the understanding and evaluation of PRP preparation methods This paper focuses on the distribution, recovery and concentration factor of platelets and leukocytes in L-PRP (leukocyte and platelet-rich plasma) to define a concentration pattern for these blood components due to centrifugation conditions...
October 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29078802/restoring-the-quantity-and-quality-of-elderly-human-mesenchymal-stem-cells-for-autologous-cell-based-therapies
#7
Travis J Block, Milos Marinkovic, Olivia N Tran, Aaron O Gonzalez, Amanda Marshall, David D Dean, Xiao-Dong Chen
BACKGROUND: Degenerative diseases are a major public health concern for the aging population and mesenchymal stem cells (MSCs) have great potential for treating many of these diseases. However, the quantity and quality of MSCs declines with aging, limiting the potential efficacy of autologous MSCs for treating the elderly population. METHODS: Human bone marrow (BM)-derived MSCs from young and elderly donors were obtained and characterized using standard cell surface marker criteria (CD73, CD90, CD105) as recommended by the International Society for Cellular Therapy (ISCT)...
October 27, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29078348/bacteriorhodopsin-like-channelrhodopsins-alternative-mechanism-for-control-of-cation-conductance
#8
Oleg A Sineshchekov, Elena G Govorunova, Hai Li, John L Spudich
The recently discovered cation-conducting channelrhodopsins in cryptophyte algae are far more homologous to haloarchaeal rhodopsins, in particular the proton pump bacteriorhodopsin (BR), than to earlier known channelrhodopsins. They uniquely retain the two carboxylate residues that define the vectorial proton path in BR in which Asp-85 and Asp-96 serve as acceptor and donor, respectively, of the photoactive site Schiff base (SB) proton. Here we analyze laser flash-induced photocurrents and photochemical conversions in Guillardia theta cation channelrhodopsin 2 (GtCCR2) and its mutants...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29074373/bone-marrow-harvest-in-pediatric-sibling-donors-role-of-granulocyte-colony-stimulating-factor-priming-and-cd34-cell-dose
#9
Aimee Furey, Sonal Rastogi, Remi Prince, Zhezhen Jin, Elana Smilow, Courtney Briamonte, Justine M Kahn, Yvette Tanhehco, Nita Patel, Diane George, James Garvin, Monica Bhatia, Prakash Satwani
To ensure optimal clinical outcomes for patients while retaining adequate protection for donors, the National Marrow Donor Program developed guidelines specifying that up to 20 mL/kg of bone marrow can be harvested from donors. These guidelines, originally developed for unrelated adult donors, are followed in children as well. We studied the impact of granulocyte colony-stimulating factor (G-CSF) priming on the cellular composition of harvested bone marrow, sought to develop an algorithm to optimize bone marrow harvest volume from pediatric matched sibling donors, and studied the impact of CD34(+) cell dose on clinical outcomes...
October 23, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29072567/never-events-and-hospital-acquired-conditions-after-kidney-transplant
#10
Linda J Chen, Zhobin Moghadamyeghaneh, Mahmoud Alameddine, Anupam K Gupta, George W Burke, Gaetano Ciancio
INTRODUCTION: Never events (NE) and hospital-acquired conditions (HAC) after surgery have been designated as quality metrics in healthcare by the centres for Medicare and Medicaid Services (CMS). METHODS: The Nationwide Inpatient Sample (NIS) database 2002-2012 was used to identify patients underwent kidney transplant. Multivariate analysis using logistic regression was used to identify outcomes and risk factors of HAC and NE after transplantation; however, we were limited by using a retrospective database missing some important variables specified for the kidney transplant, such as some operative factors, donor factors, and cold and warm ischemia times...
November 11, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29064230/development-of-dopant-free-donor-acceptor-type-hole-transporting-material-for-highly-efficient-and-stable-perovskite-solar-cells
#11
Jin Hyuck Heo, Sungmin Park, Sang Hyuk Im, Hae Jung Son
In perovskite solar cells (PSCs), overlying hole transporting materials (HTMs) are important for achieving high efficiencies as well as protecting perovskite active layers from degradation factors. This study reports the synthesis of a dopant-free HTM based on a D'-A-D-A-D-A-D' (D, D': electron donor, A: electron acceptor) conjugated structure and incorporation of the HTM into a PSC. The resulting PSC exhibits a high efficiency of 17.3%, which is comparable to that of the device based on doped spiro-OMeTAD HTM, and exhibits much improved stability: without encapsulation, the PSC based on the new HTM was found to retain 80% of its initial performance over 500 h under the conditions of 60% relative humidity/1 sun light-soaking without encapsulation...
November 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29062669/reconstruction-of-near-total-loss-of-the-upper-and-lower-lips-due-to-purpura-fulminans-with-local-tissue-and-a-dual-skin-paddled-anterolateral-thigh-flap
#12
Masamitsu Kuwahara, Satoshi Yurugi, Yuji Yamanaka, Chikako Sasaki, Takashi Nakanishi
It is difficult to totally reconstruct the lip, achieving good functional and aesthetic results. There have been few reports of reconstructing complete lip defects. Moreover, upper and lower lip necrosis by purpura fulminans has not been reported. We present a case of a 60-year-old male purpura fulminans patient with upper and lower lip necrosis. Fortunately, our patient had retained his oral commissure function. We reconstructed this defect with an orbicularis oris muscle-skin-mucosal pedicled flap derived from the region between the nasolabial folds for upper lip; a similar bipedicled flap for the lower lip and the donor site was closed with a dual-skin paddled anterolateral thigh flap...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29051810/controlled-dexamethasone-delivery-via-double-walled-microspheres-to-enhance-long-term-adipose-tissue-retention
#13
Arta Kelmendi-Doko, J Peter Rubin, Katarina Klett, Christopher Mahoney, Sheri Wang, Kacey G Marra
Current materials used for adipose tissue reconstruction have critical shortcomings such as suboptimal volume retention, donor-site morbidity, and poor biocompatibility. The aim of this study was to examine a controlled delivery system of dexamethasone to generate stable adipose tissue when mixed with disaggregated human fat in an athymic mouse model for 6 months. The hypothesis that the continued release of dexamethasone from polymeric microspheres would enhance both adipogenesis and angiogenesis more significantly when compared to the single-walled microsphere model, resulting in long-term adipose volume retention, was tested...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29047166/preassembled-coumarin-rhodamine-scaffold-for-ratiometric-sensing-of-nitric-oxide-and-hypochlorite
#14
Jun Xiang Ong, Victoria Yu Ting Pang, Li Min Tng, Wee Han Ang
A new preassembled ratiometric sensing platform was constructed from a coumarin donor and a rhodamine acceptor designed for through-bond energy transfer (TBET). A phenylacetylene linker was installed to disrupt the planarity of the extended conjugated system but retaining the efficient energy transfer between the donor and acceptor motifs. To demonstrate its versatility as a sensing platform, we conjugated recognition motifs through amide coupling reactions to yield two TBET chemosensors capable of sensing either endogenously produced NO and ClO-...
October 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29045839/heterotopic-transplantations-reveal-environmental-influences-on-interneuron-diversity-and-maturation
#15
Giulia Quattrocolo, Gord Fishell, Timothy J Petros
During embryogenesis, neural progenitors in the ganglionic eminences give rise to diverse GABAergic interneuron subtypes that populate all forebrain regions. The extent to which these cells are genetically predefined or determined by postmigratory environmental cues remains unknown. To address this question, we performed homo- and heterotopic transplantation of early postnatal MGE-derived cortical and hippocampal interneurons. Grafted cells migrated, and displayed neurochemical, electrophysiological, morphological, and neurochemical profiles similar to endogenous interneurons...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29043826/abo-serology-in-a-case-of-persistent-weak-a-in-a-recipient-following-a-group-o-matched-unrelated-bone-marrow-transplant
#16
Dianne E Grey, Elizabeth A Fong, Catherine Cole, Jesper Jensen, Jill Finlayson
HLA-matched hematopoietic stem cell transplantation (HSCT) from red blood cell (RBC)-incompatible donors is not uncommon. The engraftment process following ABO-incompatible allogeneic HSCT results in the transition from patient blood group to donor blood group in the recipient. In contrast, most non-hematopoietic tissues retain expression of the patient's original blood group for life, and these antigens may adsorb from the plasma onto the donor-derived RBCs. Correct serologic interpretation of the ABO blood group during this engraftment process can be difficult...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29037204/thoracodorsal-artery-perforator-flap-as-an-autologous-alternative-to-acellular-dermal-matrix
#17
Tarek Hashem, Ahmed Farahat
BACKGROUND: Thoracodorsal artery perforator (TDAP) flap is one of the relatively new techniques in breast reconstruction. This pedicled flap retains the benefits of perforator flaps as regards minimal donor site morbidity without the need for microvascular anastomosis. Its role in partial breast reconstruction has been well documented. However, there are few reports about the role of this flap in total breast reconstruction. METHODS: This study included 47 cases who presented to the breast unit of the National Cancer Institute of Cairo University from 2013 to 2015...
October 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29029366/directly-coupled-vs-spectator-linkers-on-diimine-pt-ii-acetylides-change-the-structure-keep-the-function
#18
Stuart Archer, Theo Keane, Milan Delor, Elizabeth Bevon, Alexander Auty, Dimitri Chekulaev, Igor Sazanovich, Michael Towrie, Antony Meijer, Julia Weinstein
A series of [Donor-Acceptor-Anchor] Platinum(II) bipy (bis)acetylides has been developed in order to systematically compare the effect of conjugated vs. electronically decoupled modes of attachment of protected anchoring groups on the photophysical properties of these light-harvesting units. This first example of "decoupled" phosphonate-diimine Pt(II) complexes presented here are compared and contrasted to their carboxylate analogs. Ultrafast TRIR and femtosecond transient absorption spectroscopies revealed that all complexes possess a charge transfer lowest excited state, with lifetimes between 2 and 14 ns...
October 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29026957/autologous-buccal-micro-mucosa-free-graft-combined-with-posterior-scrotal-flap-transfer-for-vaginoplasty-in-male-to-female-transsexuals-a-pilot-study
#19
Shu-Yi Wei, Feng-Yong Li, Qiang Li, Sen-Kai Li, Chuan-De Zhou, Yu Zhou, Yu-Jiao Cao, Si-Ya Zhang, Yang Zhao
BACKGROUND: The inverted peno-scrotal flap method is considered the standard method of vaginoplasty in male-to-female genital reassignment surgery. Though with numerous advantages, the method has its limitations regarding skin texture, lack of inherent lubrication, and that the tissues for creating the labia depend on the amount of tissues remaining after vaginoplasty. Our purpose was to describe the procedure and outcome of vaginoplasty applying a new technique: autologous buccal micro-mucosa free graft combined with posterior scrotal flap transfer, which could solve some of the problems the previous methods had...
October 12, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28989679/from-imine-to-amine-an-unexpected-left-turn-cis-%C3%AE-iron-ii-pnnp-precatalysts-for-the-asymmetric-transfer-hydrogenation-of-acetophenone
#20
Karl Z Demmans, Chris S G Seo, Alan J Lough, Robert H Morris
A novel PNN ligand bearing an orthophenylene group and a primary amine was synthesized with the aid of a palladium-catalyzed amination and reacted with phosphonium dimers [-PR2CH2CH(OH)-]2[Br]2 R = Et, iPr, Cy, Ph, xylyl, and o-Tol, and [Fe(OH2)6](2+) to produce a new series of cis-β iron(ii) PNNP' precatalysts cis-β-[Fe(Br)(CO)(PNNP')]BPh4 as a pair of diastereomers. The more stable orthophenylene amido group was chosen to imitate and replace the enamido moiety of a highly active iron precatalyst for the asymmetric transfer hydrogenation (ATH) of ketones in an attempt to prevent its deactivation caused by reduction of the enamido group...
September 1, 2017: Chemical Science
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