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Keywords Post-transplantation diabetes ...

Post-transplantation diabetes mellitus

https://read.qxmd.com/read/38274509/post-liver-transplant-renal-dysfunction-evaluation-management-and-immunosuppressive-practice
#21
REVIEW
Kaiser Raja, Charles Panackel
Liver transplantation (LT) is an effective and lifesaving treatment for patients with end-stage liver disease and hepatocellular carcinoma. Significant improvement in intermediate and long-term survival has been possible due to advancements in immunosuppressive therapy, perioperative care, and surgical techniques. Despite these advances, metabolic complications, including diabetes mellitus, cardiovascular diseases, malignancies, and renal dysfunction, are challenging issues after LT. Acute kidney injury (AKI) and chronic kidney disease (CKD) after LT are common and result in significant morbidity and mortality...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38263253/benefits-of-statin-therapy-within-a-year-after-kidney-transplantation
#22
JOURNAL ARTICLE
Seung Hyuk Yim, Hyun Jeong Kim, Han Ro, Jung-Hwa Ryu, Myung-Gyu Kim, Jae Berm Park, Chan-Duck Kim, Seungyeup Han, Sik Lee, Jaesok Yang, Kyu Ha Huh, Myoung Soo Kim, Juhan Lee
Cardiovascular disease remains a leading cause of morbidity and mortality after kidney transplantation (KT). Although statins reduce cardiovascular risk and have renal benefits in the general population, their effects on KT recipients are not well-established. We studied the effects of early statin use (within 1-year post-transplantation) on long-term outcomes in 714 KT recipients from the Korean cohort study for outcome in patients with KT. Compared with the control group, statin group recipients were significantly older, had a higher body mass index, and had a higher prevalence of diabetes mellitus...
January 23, 2024: Scientific Reports
https://read.qxmd.com/read/38251642/early-post-transplant-hyperglycemia-and-post-transplant-diabetes-mellitus-following-heart-transplantation
#23
REVIEW
William Kuang, Lisa M Raven, Christopher A Muir
INTRODUCTION: Heart transplantation is an important treatment for end-stage heart failure. Early post-transplant hyperglycemia (EPTH) and post-transplant diabetes mellitus (PTDM) are common following heart transplantation and are associated with increased morbidity and mortality. AREAS COVERED: This review summarizes the clinical characteristics, diagnosis, and treatment of EPTH and PTDM in cardiac transplant patients, incorporating findings from non-cardiac solid organ transplant studies where relevant due to limited heart-specific research...
January 16, 2024: Expert Review of Endocrinology & Metabolism
https://read.qxmd.com/read/38236408/genetic-engineering-of-regulatory-t-cells-for-treatment-of-autoimmune-disorders-including-type-1-diabetes
#24
REVIEW
Karoliina Tuomela, Megan K Levings
Suppression of pathogenic immune responses is a major goal in the prevention and treatment of type 1 diabetes. Adoptive cell therapy using regulatory T cells (Tregs), a naturally suppressive immune subset that is often dysfunctional in type 1 diabetes, is a promising approach to achieving localised and specific immune suppression in the pancreas or site of islet transplant. However, clinical trials testing administration of polyclonal Tregs in recent-onset type 1 diabetes have observed limited efficacy despite an excellent safety profile...
January 18, 2024: Diabetologia
https://read.qxmd.com/read/38231714/patency-rates-and-outcomes-of-renal-access-arteriovenous-fistulas-for-hemodialysis-in-patients-with-chronic-kidney-disease
#25
JOURNAL ARTICLE
Anil Sharma, Gaurav Sindwani, Dharamveer Singh, Rajendra Mathur, Ankit Bhardwaj
Hemodialysis remains the most popular modality of renal replacement therapy for end-stage renal disease patients with chronic kidney disease. Various factors such as a radial artery, cephalic vein diameter, age, hypertension, and diabetes mellitus can affect the fistula maturation. This study was carried out to know the patency rates and factors affecting fistula maturation in the Indian population. This is a prospective observational study which aimed to study the patency rate of arteriovenous (AV) fistulas...
May 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/38219172/the-aetiology-risk-factors-and-outcome-of-acute-kidney-injury-in-patients-requiring-kidney-replacement-therapy-a-prospective-single-center-experience
#26
JOURNAL ARTICLE
Rabeea Abbas, Tabassum Elahi, Shumaila Manan, Shafique Younas
OBJECTIVE: To find out the causes, associated leading factors and impact of kidney replacement therapy on patients hospitalised for acute kidney injury in a tertiary care setting. METHODS: The prospective, cross-sectional study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, from January 1 to March 31, 2022, and comprised patients of either gender aged 18 or more years presenting with acute kidney injury as per the Kidney Disease Improving Global Outcomes criteria and required kidney replacement therapy...
January 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38219142/predictive-factors-that-influence-the-clinical-efficacy-of-umbilical-cord-derived-mesenchymal-stromal-cells-in-the-treatment-of-type-2-diabetes-mellitus
#27
JOURNAL ARTICLE
Yuepeng Wang, Haixu Chen, Yijun Li, Haojie Hao, Jiejie Liu, Yulong Chen, Junhua Meng, Saichun Zhang, Weijun Gu, Zhaohui Lyu, Li Zang, Yiming Mu
BACKGROUND: Our previous single-center, randomized, double-blinded, placebo-controlled phase 2 study evaluated the safety and effectiveness of human umbilical cord mesenchymal stromal cell (UC-MSC) transfusion for treating patients with type 2 diabetes mellitus (T2DM). Indeed, this potential treatment strategy was able to reduce insulin use by half in a considerable number of patients. However, many other patients' responses to UC-MSC transfusion were insignificant. The selection of patients who might benefit from UC-MSC treatment is crucial from a clinical standpoint...
January 12, 2024: Cytotherapy
https://read.qxmd.com/read/38216148/a-propensity-score-matched-analysis-of-intra-and-postoperative-penile-prosthetic-complications-in-the-solid-organ-transplant-population
#28
JOURNAL ARTICLE
John C Johnson, Rahul Venna, Laith Alzweri
INTRODUCTION: Solid organ transplant (SOT) has an anticipated higher risk of penile prosthesis (PP) complications related to immunosuppression and surgical approach post-SOT. It is still not determined if PP surgery in the SOT population incurs these same higher risks. OBJECTIVES: To observe differences in intra- and postoperative PP complications between SOT and non-SOT cases from the TriNetX US Collaborative Network, a large real-world database of deidentified patient data from 56 health care organizations within the United States...
January 11, 2024: Sexual Medicine Reviews
https://read.qxmd.com/read/38195283/impact-of-obesity-on-kidney-transplant-outcomes-in-older-adults
#29
JOURNAL ARTICLE
Arvind Bakthavatsalam, Lena Sibulesky, Nicolae Leca, Stephen C Rayhill, Ramasamy Bakthavatsalam, James D Perkins
BACKGROUND: The prevalence of obesity in older patients undergoing kidney transplantation is increasing. Older age and obesity are associated with higher risks of complications and mortality post-transplantation. The optimal management of this group of patients remains undefined. METHODS: We retrospectively analyzed the United Network for Organ Sharing database of adults ≥70 years of age undergoing primary kidney transplant from January 1, 2014, to December 31, 2022...
2024: Transplantation Proceedings
https://read.qxmd.com/read/38183743/syk-blnk-nf-%C3%AE%C2%BAb-signaling-promotes-pancreatic-injury-induced-by-tacrolimus-and-potential-protective-effect-from-rapamycin
#30
JOURNAL ARTICLE
Xiao Chen, Ke Hu, Hao-Zhe Shi, Yi-Jia Zhang, Liang Chen, Su-Mei He, Dong-Dong Wang
BACKGROUND: The treatment of tacrolimus-induced post-transplantation diabetes mellitus (PTDM) has become a hot topic to improve the long-term survival of organ transplant patients, however whose pathogenesis has not been fully elucidated. In pancreas, the up-regulation of NF-κB has been reported to stimulate cytokine IL-1β/TNF-α secretion, inducing pancreatic injury, meanwhile other studies have reported the inhibitory effect of rapamycin on NF-κB. PURPOSE: The aim of this study was to clarify the mechanism of tacrolimus-induced pancreatic injury and to explore the potential effect from small dose of sirolimus...
January 5, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38173368/association-of-muscle-mass-loss-with-diabetes-development-in-liver-transplantation-recipients
#31
JOURNAL ARTICLE
Sejeong Lee, Minyoung Lee, Young-Eun Kim, Hae Kyung Kim, Sook Jung Lee, Jiwon Kim, Yurim Yang, Chul Hoon Kim, Hyangkyu Lee, Dong Jin Joo, Myoung Soo Kim, Eun Seok Kang
BACKGROUND: Post-transplant diabetes mellitus (PTDM) is one of the most significant complications after transplantation. Patients with end-stage liver diseases requiring transplantation are prone to sarcopenia, but the association between sarcopenia and PTDM remains to be elucidated. We aimed to investigate the effect of postoperative muscle mass loss on PTDM development. METHODS: A total of 500 patients who underwent liver transplantation at a tertiary care hospital between 2005 and 2020 were included...
January 3, 2024: Diabetes & Metabolism Journal
https://read.qxmd.com/read/38171510/international-consensus-on-post-transplantation-diabetes-mellitus
#32
JOURNAL ARTICLE
Adnan Sharif, Harini Chakkera, Aiko P J de Vries, Kathrin Eller, Martina Guthoff, Maria C Haller, Mads Hornum, Espen Nordheim, Alexandra Kautzky-Willer, Michael Krebs, Aleksandra Kukla, Amelie Kurnikowski, Elisabeth Schwaiger, Nuria Montero, Julio Pascual, Trond G Jenssen, Esteban Porrini, Manfred Hecking
Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity in diagnosis, risk stratification and management. However, the last decade has seen significant advancements in our PTDM knowledge complemented by rapidly changing treatment algorithms for management of diabetes in the general population. In view of these developments, and to ensure reduced variation in clinical practice, a 3rd international PTDM Consensus Meeting was planned and held between 6-8 May 2022 in Vienna, Austria involving global delegates with PTDM expertise to update the previous report...
January 3, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38152417/fixed-low-dose-versus-concentration-controlled-initial-tacrolimus-dosing-with-reduced-target-levels-in-the-course-after-kidney-transplantation-results-from-a-prospective-randomized-controlled-non-inferiority-trial-slow-low-study
#33
JOURNAL ARTICLE
Julian Stumpf, Klemens Budde, Oliver Witzke, Claudia Sommerer, Thomas Vogel, Peter Schenker, Rainer Peter Woitas, Mirian Opgenoorth, Evelyn Trips, Eva Schrezenmeier, Christian Hugo
BACKGROUND: Optimal initial tacrolimus dosing and early exposure of tacrolimus after renal transplantation is not well studied. METHODS: In this open-label, 6 months, multicenter, randomized controlled, non-inferiority study, we randomly assigned 432 renal allograft recipients to receive basiliximab induction, mycophenolate and steroids and either standard prolonged-release tacrolimus (trough levels: 7-9 ng/ml; Standard Care arm), or an initial 7-day fixed 5 mg/day dose of prolonged-release tacrolimus followed by lower tacrolimus predose levels (trough levels: 5-7 ng/ml; Slow & Low arm)...
January 2024: EClinicalMedicine
https://read.qxmd.com/read/38152359/renal-failure-following-insulin-purging-in-atypical-anorexia-nervosa-and-type-1-diabetes-mellitus
#34
JOURNAL ARTICLE
Caroline Rometsch, Martina Guthoff, Stephan Zipfel, Andreas Stengel
OBJECTIVE: Anorexia nervosa (AN) and atypical anorexia nervosa (AAN) are severe and complex eating disorders that can be prevalent among individuals with type 1 diabetes mellitus (T1DM). Insulin purging, characterized by the intentional underuse / omission of insulin to control weight, is under-recognized in medicine and is a purging strategy of patients with AN or AAN and comorbid T1DM. Often, this can lead to renal failure, necessitating a (pancreas-) kidney transplantation. This article presents a comprehensive overview of the interplay between AN/AAN and T1DM and summarizes the evidence in literature...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/38151060/influence-of-socioeconomic-factors-on-liver-transplant-survival-outcomes-in-patients-with-autoimmune-liver-disease-in-the-united-states
#35
JOURNAL ARTICLE
Leandro Sierra, Ana Marenco-Flores, Romelia Barba, Daniela Goyes, Bryan Ferrigno, Wilfor Diaz, Esli Medina-Morales, Behnam Saberi, Vilas R Patwardhan, Alan Bonder
INTRODUCTION AND OBJECTIVES: Autoimmune liver diseases (AILDs): autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) have different survival outcomes after liver transplant (LT). Outcomes are influenced by factors including disease burden, medical comorbidities, and socioeconomic variables. MATERIALS AND METHODS: Using the United Network for Organ Sharing database (UNOS), we identified 13,702 patients with AILDs listed for LT between 2002 and 2021...
December 25, 2023: Annals of Hepatology
https://read.qxmd.com/read/38143499/comparison-of-a-novel-tablet-formulation-of-tacrolimus-and-conventional-capsule-formulation-in-de-novo-kidney-transplant-recipients-a-systematic-review-and-meta-analysis
#36
Zhenyu Liu, Kexin Yin, Huiqian Liu, Ning Wang, Junjie Yao, Jiangtao Zhou, Yongxi Tang, Zhikang Yin
Background: The work aimed to compare the pharmacokinetic (PK) profiles and other outcomes reported in observational studies in de novo kidney transplant recipients (KTRs) receiving novel once-daily extended-release tablet tacrolimus (LCPT; LCP-tacrolimus; Envarsus XR) or receiving standard-of-care capsule tacrolimus (PR-Tac; prolonged-release tacrolimus; Advagraf/IR-Tac; immediate-release tacrolimus; Prograf). Methods: A systematic review was conducted for all randomized controlled trials (RCTs) and cohort studies investigating the outcomes in KTRs receiving LCPT or PR-Tac/IR-Tac...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38140692/metformin-and-hepatocellular-carcinoma-risk-reduction-in-diabetic-patients-with-chronic-hepatitis-c-fact-or-fiction
#37
REVIEW
Marco Sacco, Davide Giuseppe Ribaldone, Giorgio Maria Saracco
BACKGROUND: Patients with chronic hepatitis C (CHC) and concomitant type 2 diabetes mellitus (DM) show a higher risk of developing hepatocellular carcinoma (HCC). Successful antiviral therapy has reduced the incidence of post-therapy HCC, but the presence of DM still represents an unfavourable predictive factor even in cured patients. Metformin (MET) is recommended as a first-line therapy for DM, and its use is associated with a significant reduction in HCC among diabetic patients with chronic liver disease of different etiology, but very few studies specifically address this issue in patients with CHC...
December 17, 2023: Viruses
https://read.qxmd.com/read/38139229/childhood-obesity-insight-into-kidney-involvement
#38
REVIEW
Nazareno Carullo, Mariateresa Zicarelli, Ashour Michael, Teresa Faga, Yuri Battaglia, Antonio Pisani, Maria Perticone, Davide Costa, Nicola Ielapi, Giuseppe Coppolino, Davide Bolignano, Raffaele Serra, Michele Andreucci
This review examines the impact of childhood obesity on the kidney from an epidemiological, pathogenetic, clinical, and pathological perspective, with the aim of providing pediatricians and nephrologists with the most current data on this topic. The prevalence of childhood obesity and chronic kidney disease (CKD) is steadily increasing worldwide, reaching epidemic proportions. While the impact of obesity in children with CKD is less pronounced than in adults, recent studies suggest a similar trend in the child population...
December 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38138933/adverse-drug-events-after-kidney-transplantation
#39
REVIEW
Lionel Rostaing, Thomas Jouve, Florian Terrec, Paolo Malvezzi, Johan Noble
Introduction: Kidney transplantation stands out as the optimal treatment for patients with end-stage kidney disease, provided they meet specific criteria for a secure outcome. With the exception of identical twin donor-recipient pairs, lifelong immunosuppression becomes imperative. Unfortunately, immunosuppressant drugs, particularly calcineurin inhibitors like tacrolimus, bring about adverse effects, including nephrotoxicity, diabetes mellitus, hypertension, infections, malignancy, leukopenia, anemia, thrombocytopenia, mouth ulcers, dyslipidemia, and wound complications...
December 14, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/38131015/predicting-type-2-diabetes-risk-before-and-after-solid-organ-transplantation-using-polygenic-scores-in-a-danish-cohort
#40
JOURNAL ARTICLE
Quenia Dos Santos, Preston Leung, Christian W Thorball, Bruno Ledergerber, Jacques Fellay, Cameron R MacPherson, Mads Hornum, Cynthia Terrones-Campos, Allan Rasmussen, Finn Gustafsson, Michael Perch, Søren S Sørensen, Christina Ekenberg, Jens D Lundgren, Bo Feldt-Rasmussen, Joanne Reekie
Type 2 diabetes mellitus (T2DM) can be multifactorial where both genetics and environmental factors play a role. We aimed to investigate the use of polygenic risk scores (PRS) in the prediction of pre-transplant T2DM and post-transplant diabetes mellitus (PTDM) among solid organ transplant (SOT) patients. Using non-genetic risk scores alone; and the combination with PRS, separate logistic regression models were built and compared using receiver operator curves. Patients were assessed pre-transplant and in three post-transplant periods: 0-45, 46-365 and >365 days...
2023: Frontiers in Molecular Biosciences
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