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Post-transplantation diabetes mellitus

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https://www.readbyqxmd.com/read/27909287/elevated-fasting-plasma-glucose-before-liver-transplantation-is-associated-with-lower-post-transplant-survival
#1
Emi Katsura, Tatsuki Ichikawa, Naota Taura, Hisamitsu Miyaaki, Satoshi Miuma, Hidetaka Shibata, Takuya Honda, Masaaki Hidaka, Akihiko Soyama, Fuminao Takeshima, Susumu Eguchi, Kazuhiko Nakao
BACKGROUND The risk of liver cirrhosis is higher among individuals with diabetes mellitus, and a cirrhotic patient with diabetes may have a poorer prognosis after liver transplantation compared to a patient without diabetes. Thus, we evaluated whether fasting plasma glucose prior to receiving a liver transplant was a prognostic factor for post-transplant survival. MATERIAL AND METHODS Ninety-one patients received a living donor liver transplant between November 2005 and December 2012. Patients were considered diabetic if they were prescribed diabetes medications or had impaired glucose tolerance as measured by an oral glucose tolerance test...
December 2, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27862344/diabetes-mellitus-after-kidney-transplantation-in-japanese-patients-the-japan-academic-consortium-of-kidney-transplantation-study
#2
Masayoshi Okumi, Kohei Unagami, Toshihito Hirai, Tomokazu Shimizu, Hideki Ishida, Kazunari Tanabe
OBJECTIVES: To clarify the incidence rate of post-transplant diabetes mellitus and associated risk factors in Japanese kidney transplant recipients, and to explore which treatment components are most effective in reducing post-transplant diabetes mellitus. METHODS: We analyzed 849 Japanese non-diabetic adult recipients who had undergone living kidney transplantation and had received tacrolimus-based immunosuppression from 1996 to 2013 with a median follow-up of 5 years...
November 11, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27859633/visceral-fat-is-strongly-associated-with-post-transplant-diabetes-mellitus-and-glucose-metabolism-one-year-after-kidney-transplantation
#3
Marit Elizabeth von Düring, Trond Jenssen, Jens Bollerslev, Anders Åsberg, Kristin Godang, Anders Hartmann
Body composition after kidney transplantation is linked to glucose metabolism, and impaired glucose metabolism is associated with increased risk of cardiovascular events and death. One year after transplantation we examined 150 patients for new-onset diabetes performing OGTTs and body composition measurements including visceral adipose tissue (VAT) content from dual-energy X-ray absorptiometry scans. We found that glucose metabolism was generally improved and that the levels of VAT and percentage VAT of total body fat mass (VAT%totBFM ) were lowest in those with normal glucose tolerance and highest in those with post transplant diabetes mellitus...
November 16, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27837276/new-onset-diabetes-mellitus-after-living-donor-liver-transplantation-association-with-graft-synthetic-function
#4
Shintaro Yagi, Toshimi Kaido, Taku Iida, Atsushi Yoshizawa, Hideaki Okajima, Shinji Uemoto
BACKGROUND AND PURPOSE: It is now known that post-transplant graft function after deceased-donor liver transplantation and living-donor liver transplantation (LDLT) differ; however, there is no report assessing the relationship between graft function and the development of new-onset diabetes mellitus after transplantation (NODAT). We conducted this study to identify the predictive risk factors for NODAT, including graft function after LDLT. METHODS: The subjects of this study were 175 adult recipients who underwent LDLT at Kyoto University Hospital between 2006 and 2010, and survived for more than 3 months (median observation period, 1046 days)...
November 11, 2016: Surgery Today
https://www.readbyqxmd.com/read/27833730/general-diseases-influence-on-peri-implantitis-development-a-systematic-review
#5
REVIEW
Zygimantas Guobis, Ingrida Pacauskiene, Inesa Astramskaite
OBJECTIVES: To systematically review the influence of systemic diseases or medications used in their treatment on the dental implant therapy success. MATERIAL AND METHODS: The search strategy was implemented on the National Library of Medicine database (MEDLINE) (Ovid) and EMBASE electronic databases between January 2006 and January 2016. Human studies with available English articles analysing the relationship between dental implant therapy success and systemic diseases, such as diabetes mellitus, AIDS/HIV, rheumatoid arthritis, osteoporosis, Crohn's disease, cardiovascular diseases, scleroderma, Sjögren's syndrome, lichen planus, ectodermal dysplasia, post-transplantation status, were included in present review according to the PRISMA guidelines...
July 2016: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/27833442/stat4-gene-polymorphism-in-patients-after-renal-allograft-transplantation
#6
Ewa Dąbrowska-Żamojcin, Violetta Dziedziejko, Krzysztof Safranow, Leszek Domański, Sylwia Słuczanowska-Głabowska, Andrzej Pawlik
INTRODUCTION: STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, we examined whether this polymorphism is associated with the early and late functions of renal allografts...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27826056/prognosis-of-patients-with-chronic-hepatitis-b-in-france-2008-2013-a-nationwide-observational-and-hospital-based-study
#7
Vincent Mallet, Kamal Hamed, Michaël Schwarzinger
BACKGROUND AND AIMS: How risk factors associated with chronic hepatitis B (CHB) modify liver disease progression and mortality has been scarcely reported outside of Asia. METHODS: All individuals discharged with CHB from acute and post-acute care hospitals in Metropolitan France between January 2008 and December 2013 were selected. Associations between liver- and non-liver-related risk factors and both liver disease progression (end-stage liver disease or hepatocellular carcinoma) and mortality were assessed by multivariate Cox proportional hazard models...
November 5, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27798516/poor-glycemic-control-is-associated-with-decreased-survival-in-lung-transplant-recipients
#8
Kathryn L Hackman, Gregory I Snell, Leon A Bach
BACKGROUND: Diabetes mellitus (DM) is associated with increased mortality following transplantation, but the effect of glycemic control on survival is unknown.We sought to determine the relationship between glycemic control (random (RBG) and fasting (FBG) blood glucose, HbA1c) and survival in all lung transplant (LTx) recipients and those with either persistent or no DM. METHODS: All 210 LTx recipients from 1 August 2010 - 1 November 2013 were included (median observation 3...
October 28, 2016: Transplantation
https://www.readbyqxmd.com/read/27761671/preemptive-kidney-transplantation-a-propensity-score-matched-cohort-study
#9
Masayoshi Okumi, Yasuyuki Sato, Kohei Unagami, Toshihito Hirai, Hideki Ishida, Kazunari Tanabe
BACKGROUND: The reasons for improved outcomes associated with preemptive kidney transplantation (PKT) are incompletely understood, and post-transplant complications have been scarcely investigated. METHODS: We evaluated the outcomes of PKT in both unmatched (n = 1060) and propensity score matched cohorts (n = 186) of adults who underwent living kidney transplant between 2000 and 2014. Outcomes were estimated glomerular filtration rate (eGFR), biopsy-proven rejection, cytomegalovirus (CMV) infection, post-transplant diabetes mellitus (PTDM), cardiovascular disease (CVD), graft failure (non-censored for death), and malignancy...
October 19, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27742277/kidney-transplantation-at-a-southern-brazilian-university-hospital-a-35-year-practice-review
#10
L V Kroth, F F Barreiro, D Saitovitch, M A Traesel, D O d'Avila, C E Poli-de-Figueiredo
BACKGROUND: The Nephrology Unit at São Lucas Hospital, a University Hospital in Southern Brazil, has recently reached 35 years since its first kidney transplant. Few centers in the area have made a longitudinal analysis of processes, problems, grafts, and patient survival changes along this time. METHODS: A single-center, retrospective study was performed. Data were separated into different eras, based on the nature of immunosuppression used: pre-cyclosporine (1978-1986), cyclosporine (1987-1997), mycophenolate introduction (1998-2002), new immunosuppressant drugs (2003-2007), and the current period (2008-2013)...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27738945/microencapsulation-of-islets-for-the-treatment-of-type-1-diabetes-mellitus-t1d
#11
Riccardo Calafiore, Giuseppe Basta, Pia Montanucci
Microencapsulation technology, based on use of alginic acid biopolymers, has been devised many years ago. However, when intended for enveloping human islets for transplantation purposes, the method needs to be up-scaled and implemented with care being taken to comply with simple but important measures. It is almost indispensable to rely on an ultrapurified alginic polymers: in fact, any, even minimal, alginate contamination with endotoxins, pyrogens, and proteins could provoke the host's inflammatory reaction upon graft, with heavy adverse consequences on the capsules immunoprotective properties, hence on graft survival per se...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27721964/correlation-between-cmv-infection-and-post-transplantation-new-onset-diabetes-mellitus
#12
I Dedinská, Ľ Laca, J Miklušica, D Kantárová, P Galajda, M Mokáň
BACKGROUND: New-onset diabetes mellitus after transplantation (NODAT) is a well-known complication of transplantation. OBJECTIVE: To determine the correlation between CMV infection and NODAT. METHODS: Retrospectively, we detected CMV replication (PCR) in every month after renal transplantation in the first 12 months of the procedure in a homogenous group of patients from the immunosuppression point of view. RESULTS: In 167 patients (64 with NODAT and 103 in the control group), the average amount of CMV viremia was not significantly different between the NODAT and the control group (p=0...
2016: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/27706207/adiponectin-fractions-influence-the-development-of-posttransplant-diabetes-mellitus-and-cardiovascular-disease-in-japanese-renal-transplant-recipients
#13
Hiroki Adachi, Kanae Nakayama, Norifumi Hayashi, Yuki Matsui, Keiji Fujimoto, Hideki Yamaya, Hisao Tonami, Hitoshi Yokoyama
BACKGROUND: A few studies have investigated the role of adiponectin fraction for cardiovascular disease (CVD) in RTx recipients. SUBJECTS AND METHODS: We studied 57 adult subjects (39 males, 18 females; 10 cadaveric donors) with at least three years of allograft survival (median 251 months). We examined clinical backgrounds such as treated drugs, blood pressure (BP, mmHg), body mass index (BMI), and blood chemistry including cholesterol (total, LDL-C, HDL-C), glucose, glycated hemoglobin (HbA1c), and serum high and low-molecular-weight (HMW/LMW) ADPN fractions with regard to the associations of the visceral and subcutaneous fat areas on CT scan...
2016: PloS One
https://www.readbyqxmd.com/read/27665059/drug-drug-interactions-between-immunosuppressants-and-antidiabetic-drugs-in-the-treatment-of-post-transplant-diabetes-mellitus
#14
Thomas Vanhove, Quinten Remijsen, Dirk Kuypers, Pieter Gillard
Post-transplant diabetes mellitus is a frequent complication of solid organ transplantation that generally requires treatment with lifestyle interventions and antidiabetic medication. A number of demonstrated and potential pharmacokinetic drug-drug interactions (DDIs) exist between commonly used immunosuppressants and antidiabetic drugs, which are comprehensively summarized in this review. Cyclosporine (CsA) itself inhibits the cytochrome P450 (CYP) 3A4 enzyme and a variety of drug transporters. As a result, it increases exposure to repaglinide and sitagliptin, will likely increase the exposure to nateglinide, glyburide, saxagliptin, vildagliptin and alogliptin, and could theoretically increase the exposure to gliquidone and several sodium-glucose transporter (SGLT)-2 inhibitors...
September 14, 2016: Transplantation Reviews
https://www.readbyqxmd.com/read/27648010/association-of-inflammation-prior-to-kidney-transplantation-with-post-transplant-diabetes-mellitus
#15
Maria P Martinez Cantarin, Scott W Keith, Zhao Lin, Cataldo Doria, Adam M Frank, Warren R Maley, Carlo Ramirez, Costas D Lallas, Ashesh Shah, Scott A Waldman, Bonita Falkner
BACKGROUND/OBJECTIVE: Post-transplant diabetes mellitus (PTDM) is both common and associated with poor outcomes after kidney transplantation. Our objective was to examine relationships of uremia-associated inflammation and adiponectin with PTDM. METHODS: Nondiabetic kidney transplant patients were enrolled with donor controls. Inflammatory cytokines and adiponectin were measured before and after transplantation. Adipose tissue was obtained for gene expression analysis...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27642745/-posttransplantation-diabetes-mellitus-in-patients-after-kidney-transplantation-incidence-and-risk-factors
#16
Isabell Jahn, Martin Busch, Undine Ott, Gunter Wolf, Wilgard Battefeld
BACKGROUND: Transplantation (NTX) associated ischemia-reperfusion-mechanisms and the predisposition for insulin resistance are discussed as causes of a posttransplantation diabetes mellitus (PTDM). Furthermore, immunosuppressants can have a damaging effect on insulin secretion. METHODS: 55 metabolically healthy patients with an endstage renal disease (age 52 ± 14 years, body mass index 27 ± 5 kg / m(2), blood pressure 137 ± 15/82 ± 11 mmHg) were included in a prospectively cohort study...
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27626495/nationwide-population-based-study-reveals-increased-malignancy-risk-in-taiwanese-liver-transplant-recipients
#17
Yung Fong Tsai, Hsiu Pin Chen, Fu Chao Liu, Shih Hao Liu, Chun Yu Chen, Chih Wen Cheng, Jr Rung Lin
Post-transplant malignancy is a major cause of late mortality for liver transplant recipients (LTRs). This nationwide population-based cohort study investigated the cancer type, incidence, and risk factors associated with post-transplant malignancies in 2938 Taiwanese LTRs who underwent transplantation between 1998 and 2012. Data from the National Health Insurance Research Database were extracted on the basis of the International Classification of Disease, Ninth Revision, Clinical Modification codes. Among these patients, 284 post-transplant malignancies were diagnosed...
September 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27621191/risk-assessment-and-management-of-post-transplant-diabetes-mellitus
#18
REVIEW
Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
The success rate of organ transplantation has been increasing with advances in surgical and pharmacological techniques. However, the number of solid organ transplant recipients who require metabolic disease management is also growing. Post-transplant diabetes mellitus (PTDM) is a common complication after solid organ transplantation and is associated with risks of graft loss, cardiovascular morbidity, and mortality. Other risk factors for PTDM include older age, genetic background, obesity, hepatitis C virus infection, hypomagnesemia, and use of immunosuppressant agents (corticosteroids, calcineurin inhibitors, and mammalian target of rapamycin inhibitor)...
October 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27605877/metabolic-complications-in-liver-transplant-recipients
#19
REVIEW
Miguel Jiménez-Pérez, Rocío González-Grande, Edith Omonte Guzmán, Víctor Amo Trillo, Juan Miguel Rodrigo López
The metabolic syndrome (MS), which includes obesity, dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease (CVD) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVD and death of 1...
July 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27577068/sirolimus-and-metformin-synergistically-inhibit-hepatocellular-carcinoma-cell-proliferation-and-improve-long-term-survival-in-patients-with-hcc-related-to-hepatitis-b-virus-induced-cirrhosis-after-liver-transplantation
#20
Chuan Shen, Chenghong Peng, Baiyong Shen, Zhecheng Zhu, Ning Xu, Tao Li, Junjie Xie
Immunosuppressive agents used postoperatively after liver transplantation (LT) for hepatocellular carcinoma (HCC) favor recurrence and metastasis. Therefore, new effective immunosuppressants are needed. This retrospective study assessed combined sirolimus and metformin on survival of HCC patients after LT. In 2001-2013, 133 HCC patients with LT were divided into four groups: sirolimus and metformin combination (Sir+Met), sirolimus monotherapy (Sir), other immunosuppressants in diabetes mellitus (DM) patients without metformin (No Sir with DM), and other immunosuppressants in patients without DM (No Sir without DM)...
August 25, 2016: Oncotarget
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