keyword
MENU ▼
Read by QxMD icon Read
search

sepsis,

keyword
https://www.readbyqxmd.com/read/28738231/sliding-strip-microfluidic-device-enables-elisa-on-paper
#1
Mohit S Verma, Maria-Nefeli Tsaloglou, Tyler Sisley, Dionysios Christodouleas, Austin Chen, Jonathan Milette, George M Whitesides
This article describes a 3D microfluidic paper-based analytical device that can be used to conduct an enzyme-linked immunosorbent assay (ELISA). The device comprises two parts: a sliding strip (which contains the active sensing area) and a structure surrounding the sliding strip (which holds stored reagents-buffers, antibodies, and enzymatic substrate-and distributes fluid). Running an ELISA involves adding sample (e.g. blood) and water, moving the sliding strip at scheduled times, and analyzing the resulting color in the sensing area visually or using a flatbed scanner...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28738028/ebv-hlh-children-with-reductions-in-cd4-t-cells-and-excessive-activation-of-cd8-t-cells
#2
Cheng Yang, Xiujuan Zhu, Ting Zhang, Qing Ye
BACKGROUND: In this report, we analyzed the number and activation profiles of T cells in EBV-HLH patients and assessed their value for the diagnosis of EBV-HLH. METHODS: We compared the quantity of CD4+ T cells and CD8+ T cells in peripheral blood among HLH patients, a sepsis group and healthy controls. We then analyzed variations in the activation marker in CD4+ T cells and CD8+ T cells. RESULTS: The percentage of CD4+ T cells decreased in the EBV-HLH patients compared to healthy controls, which induced significant differences in the ratio of CD4+ T cells/CD8+ T cells...
July 24, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28737878/-unusual-case-of-food-protein-induced-enterocolitis-syndrome
#3
M Teresa Sobrevia Elfau, Yolanda Aliaga Mazas, Gonzalo Herraiz Gastesi, Paula M Barberá Pérez, Ángela M Ascaso Matamala
Food protein-induced enterocolitis syndrome is a nonimmunoglobulin E mediated gastrointestinal food hypersensitivity that manifests as profuse, repetitive vomiting, pallor and hypotonia, often with diarrhea leading to severe dehydration and lethargy (sepsis-like symptoms) in the acute setting. An oral food challenge is sometimes performed to confirm the diagnosis and treatment consists of elimination of the food trigger(s) from the diet. We report a case of a 3-monthsold infant with several episodes of food protein-induced enterocolitis syndrome after taking infant formula milk with tolerance of another trademark...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737626/perinatal-chikungunya-virus-associated-encephalitis-leading-to-postnatal-onset-microcephaly-and-optic-atrophy
#4
Regina Ramos, Rafaela Viana, Alessandra Brainer-Lima, Telma Florêncio, Maria Durce Carvalho, Vanessa van Der Linden, Antonio Amorim, Maria Ângela Rocha, Fabíola Medeiros
Chikungunya virus is capable of affecting the nervous system of children and adults. We describe a case of sepsis and encephalitis triggered by this agent in a newborn whose mother developed symptoms of acute infection two days before delivery. Consequently, the infant had severe encephalitis that evolved with postnatal-onset microcephaly, bilateral optic atrophy, epilepsy and cerebral palsy.
July 21, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28737575/diabetes-is-not-associated-with-increased-90-day-mortality-risk-in-critically-ill-patients-with-sepsis
#5
Lonneke A van Vught, Rebecca Holman, Evert de Jonge, Nicolette F de Keizer, Tom van der Poll
OBJECTIVES: To determine the association of pre-existing diabetes, hyperglycemia, and hypoglycemia during the first 24 hours of ICU admissions with 90-day mortality in patients with sepsis admitted to the ICU. DESIGN: We used mixed effects logistic regression to analyze the association of diabetes, hyperglycemia, and hypoglycemia with 90-day mortality (n = 128,222). SETTING: All ICUs in the Netherlands between January 2009 and 2014 that participated in the Dutch National Intensive Care Evaluation registry...
July 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28737573/investigating-the-impact-of-different-suspicion-of-infection-criteria-on-the-accuracy-of-quick-sepsis-related-organ-failure-assessment-systemic-inflammatory-response-syndrome-and-early-warning-scores
#6
Matthew M Churpek, Ashley Snyder, Sarah Sokol, Natasha N Pettit, Dana P Edelson
OBJECTIVE: Studies in sepsis are limited by heterogeneity regarding what constitutes suspicion of infection. We sought to compare potential suspicion criteria using antibiotic and culture order combinations in terms of patient characteristics and outcomes. We further sought to determine the impact of differing criteria on the accuracy of sepsis screening tools and early warning scores. DESIGN: Observational cohort study. SETTING: Academic center from November 2008 to January 2016...
July 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28737139/the-confrontation-of-fungal-sepsis-in-neonates
#7
Rumpa Saha
No abstract text is available yet for this article.
July 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28736121/potential-of-circulatory-procalcitonin-as-a-biomarker-reflecting-inflammation-among-south-indian-diabetic-foot-ulcers
#8
Dhamodharan Umapathy, Sireesh Dornadula, Arvind Rajagopalan, Narayana Murthy, Vairamani Mariappanadar, Rajesh Kesavan, Ramkumar Kunka Mohanram
OBJECTIVE: Diabetic foot ulcer (DFU), the major complication associated with diabetes mellitus, has been shown to precede amputation in up to 90% of cases. Recent data reveal that procalcitonin (PCT) is a valid marker for the diagnosis of bacterial infections compared with traditional markers like white blood cell count, C-reactive protein levels, and erythrocyte sedimentation rate in DFU patients. Furthermore, cytokines are proposed to act as modulators and mediators for the expression and release of PCT into the circulation...
July 20, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28736010/predictors-of-mortality-in-living-donor-liver-transplantation
#9
S Elkholy, S Mogawer, A Hosny, M El-Shazli, U M Al-Jarhi, S Abdel-Hamed, A Salah, N El-Garem, A Sholkamy, M El-Amir, M S Abdel-Aziz, A Mukhtar, A El-Sharawy, A Nabil
BACKGROUND: Egypt has the highest prevalence of the world hepatitis C virus (HCV) load. Hence, the problem of end-stage liver disease (ESLD) is considered a huge burden on the community. Living donor liver transplantation (LDLT) is the only source of donation in Egypt till now. Survival rates had shown significant improvement in the past decades. This study provides analysis of the mortality rates and possible predictors of mortality following LDLT. It also aids in developing a practical and easy-to-apply risk index for prediction of early mortality...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735809/antibiotic-stewardship-in-perinatal-and-neonatal-care
#10
REVIEW
Jayashree Ramasethu, Tetsuya Kawakita
The spread of antibiotic resistance due to the use and misuse of antibiotics around the world is now a major health crisis. Neonates are exposed to antibiotics both before and after birth, often empirically because of risk factors for infection, or for non-specific signs which may or may not indicate sepsis. There is increasing evidence that, apart from antibiotic resistance, the use of antibiotics in pregnancy and in the neonatal period alters the microbiome in the fetus and neonate with an increased risk of immediate and long-term adverse effects...
July 20, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28735154/accuracy-of-c-reactive-protein-as-a-bacterial-infection-marker-in-critically-immunosuppressed-patients-a-systematic-review-and-meta-analysis
#11
REVIEW
Vanessa Martins de Oliveira, Rafael Barberena Moraes, Airton Tetelbom Stein, Eliana Márcia Wendland
BACKGROUND: There is a need for a better understanding of the role of C-reactive protein (CRP) as a valid marker for the detection of bacterial infections in critically immunosuppressed patients. A high negative predictive value of CRP is also needed to rule out sepsis and bacterial infections in immunocompetent patients. However, few studies have evaluated the performance of CRP in immunocompromised hosts. The aim of the present study was to evaluate the performance of CRP as a marker of infection in critically immunosuppressed patients...
July 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28735135/endoscope-assisted-abscess-drainage-secondary-to-endoscope-assisted-tlif-1-year-follow-up
#12
Karthik Madhavan, Steven Shelby Burks, Lee Onn Chieng, Anand Veeravagu, Michael Y Wang
INTRODUCTION: Endoscopic discectomy and fusions have been gaining popularity in the recent past and are noted to be safe for its application in elderly population. It involves ultra-small incision for discectomy followed by placement of percutaneous screws in awake patients. Treatment of advanced spinal pathology using endoscope-assisted techniques are challenging. Although not common with endoscopic approach, post-operative infection can be problematic as there are no established guidelines on its management...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28734690/salivary-c-reactive-protein-mean-platelet-volume-and-neutrophil-lymphocyte-ratio-as-diagnostic-markers-for-neonatal-sepsis
#13
Ahmed Omran, Abdallah Maaroof, Mai H Saleh, Amina Abdelwahab
OBJECTIVE: To assess the applicability of salivary C-reactive protein (CRP), mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and platelet lymphocyte ratio (PLR) in the diagnosis of neonatal sepsis. METHODS: Prospective case-control study of 70 full-term neonates, 35 with sepsis (20 with proven sepsis and 15 with clinical sepsis) and 35 healthy controls. Serum and salivary CRP concentrations were measured by ELISA while MPV, NLR, and PLR were measured by automated blood cell counter...
July 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28734608/sequence-specific-dna-solid-phase-extraction-in-an-on-chip-monolith-towards-detection-of-antibiotic-resistance-genes
#14
Radim Knob, Daniel B Nelson, Richard A Robison, Adam T Woolley
Antibiotic resistance of bacteria is a growing problem and presents a challenge for prompt treatment in patients with sepsis. Currently used methods rely on culturing or amplification; however, these steps are either time consuming or suffer from interference issues. A microfluidic device was made from black polypropylene, with a monolithic column modified with a capture oligonucleotide for sequence selective solid-phase extraction of a complementary target from a lysate sample. Porous properties of the monolith allow flow and hybridization of a target complementary to the probe immobilized on the column surface...
July 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28734159/development-of-a-lc-ms-ms-method-for-the-determination-of-ckd-712-in-rat-plasma-application-to-a-pharmacokinetic-study-in-rats
#15
Jung-Woo Chae, Hwi-Yeol Yun, Han Young Eom, Eun Ju Jeong, Tae-Sung Koo, Kwang-Il Kwon, Jong-Hwa Lee
CKD-712 is a potential treatment for sepsis, as it exhibits protective effects against lipopolysaccharide-mediated platelet aggregation, inducible nitric oxide synthase expression, and cecum-ligation puncture-induced septic mortality in mice. In this study, we develop a rapid and sensitive LC-MS/MS method for determining CKD-712 in rat plasma. CKD-712 and papaverine hydrochloride (an internal standard) were analyzed using an LC-MS/MS system consisting of an Agilent HPLC system (HP-1100) equipped with an Atlantis HILIC Silica (2...
July 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28733741/tips-and-tricks-of-splenic-vessel-preservation-during-laparoscopic-distal-pancreatectomy
#16
Claire Goumard, Satoshi Ogiso, Masayuki Okuno, Jason B Fleming, Michael Kim, Ching-Wei D Tzeng, Jean-Nicolas Vauthey, Jeffrey E Lee, Claudius Conrad
BACKGROUND: While a laparoscopic approach can minimize postoperative morbidity in splenic vessel preserving (SVP) distal pancreatectomy (DP), this procedure can be technically challenging. A systematic approach to SVP minimizes the chances of vascular injury and maximizes the chances of successful splenic preservation. This video demonstrates a laparoscopic DP with SVP, highlighting technical tips and tricks that optimize the chances for SVP. PATIENT: The patient is a 14-year-old male with an incidentally discovered pancreatic tail mass...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28733486/%C3%AE-toxin-regulates-local-granulocyte-expansion-from-hematopoietic-stem-and-progenitor-cells-in-staphylococcus-aureus-infected-wounds
#17
Patrick C Falahee, Leif S Anderson, Mack B Reynolds, Mauricio Pirir, Bridget E McLaughlin, Carly A Dillen, Ambrose L Cheung, Lloyd S Miller, Scott I Simon
The immune response to Staphylococcus aureus infection in skin involves the recruitment of polymorphonuclear neutrophils (PMNs) from the bone marrow via the circulation and local granulopoiesis from hematopoietic stem and progenitor cells (HSPCs) that also traffic to infected skin wounds. We focus on regulation of PMN number and function and the role of pore-forming α-toxin (AT), a virulence factor that causes host cell lysis and elicits inflammasome-mediated IL-1β secretion in wounds. Infection with wild-type S...
July 21, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28732537/negative-pressure-wound-therapy-versus-modified-barker-vacuum-pack-as-temporary-abdominal-closure-technique-for-open-abdomen-management-a-four-year-experience
#18
Giulia Montori, Niccolò Allievi, Federico Coccolini, Leonardo Solaini, Luca Campanati, Marco Ceresoli, Paola Fugazzola, Roberto Manfredi, Stefano Magnone, Matteo Tomasoni, Luca Ansaloni
BACKGROUND: We reviewed our experience with patients presenting with trauma and peritonitis who underwent an open abdomen (OA) procedure, and compared outcomes between Negative Pressure Wound Therapy (NPWT) and a modified Barker Vacuum Pack (mBVP) technique. METHODS: In this descriptive study, we retrospectively analyzed data regarding all patients who underwent OA for intra-abdominal sepsis or abdominal trauma at our Centre from January 2012 to December 2015. Demographic data, co-morbidities, indications to surgery, intra-operative details and Björck classification grade were considered...
July 21, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28732148/trends-of-hospitalization-for-serious-infections-in-patients-with-rheumatoid-arthritis-in-the-us-between-1993-and-2013
#19
Sadao Jinno, Na Lu, S Reza Jafarzadeh, Maureen Dubreuil
BACKGROUND/OBJECTIVE: Epidemiology of hospitalizations with infection among patients with rheumatoid arthritis (RA) is unknown despite an increase in RA treatments that confer infection risk. METHODS: We examined National Inpatient Sample data from 1993-2013. We identified adults RA hospitalizations, defined by having ICD-9-CM codes (714.xx) in any secondary diagnosis field. We evaluated 5 infections as the primary diagnosis: pneumonia, sepsis, urinary tract infection (UTI), skin and soft tissue infections (SSTI), and opportunistic infections (OIs)...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28731912/assessing-infant-and-maternal-readiness-for-newborn-discharge
#20
Ling Jing, Casidhe-Nicole Bethancourt, Thomas McDonagh
PURPOSE OF REVIEW: The review highlights the shift from prescribed length of stay (LOS) to mother-infant dyad readiness as the basis for making discharge decisions for healthy term newborns. We describe the components of readiness that should be considered in making the decision, focusing on infant clinical readiness, and maternal and familial readiness. RECENT FINDINGS: Although the Newborns' and Mothers' Health Protection Act of 1996 aimed to protect infants and mothers by establishing a minimum LOS, the American Academy of Pediatrics 2015 policy on newborn discharge acknowledges the shift from LOS-based to readiness-based discharge decision-making...
July 20, 2017: Current Opinion in Pediatrics
keyword
keyword
62733
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"