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Mediastinal lymphadenopathy

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https://www.readbyqxmd.com/read/28723801/multidisciplinary-approach-and-long-term-follow-up-in-a-series-of-640-consecutive-patients-with-sarcoidosis-cohort-study-of-a-40-year-clinical-experience-at-a-tertiary-referral-center-in-barcelona-spain
#1
Juan Mañá, Manuel Rubio-Rivas, Nadia Villalba, Joaquim Marcoval, Adriana Iriarte, María Molina-Molina, Roger Llatjos, Olga García, Sergio Martínez-Yélamos, Vanessa Vicens-Zygmunt, Cristina Gámez, Ramón Pujol, Xavier Corbella
Cohort studies of large series of patients with sarcoidosis over a long period of time are scarce. The aim of this study is to report a 40-year clinical experience of a large series of patients at Bellvitge University Hospital, a tertiary university hospital in Barcelona, Spain. Diagnosis of sarcoidosis required histological confirmation except in certain specific situations. All patients underwent a prospective study protocol. Clinical assessment and follow-up of patients were performed by a multidisciplinary team...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28712157/training-and-proficiency-in-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-a-systematic-review
#2
REVIEW
Inderpaul S Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal, Ritesh Agarwal
Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) is currently the modality of choice for evaluation of mediastinal lymphadenopathy. However, there is still uncertainty regarding the training methodology and the number of procedures required to attain proficiency in EBUS. Herein, we performed a systematic review of studies selected from PubMed, EmBase and Scopus databases describing the training and assessment of proficiency during EBUS, specifically studies investigating various methods for training, its outcome and the number of procedures required to overcome the learning curve for EBUS...
July 16, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28709488/endobronchial-ultrasound-experience-in-a-high-tuberculosis-prevalence-setting
#3
Balamugesh Thangakunam, Barney Thomas Jesudason Isaac, Devasahayam Jesudas Christopher
BACKGROUND: Most of the published endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) data are from the western countries, establishing the role of EBUS-TBNA in the diagnosis and staging of lung cancer. The etiology of mediastinal lymphadenopathy may be different in an ethnic group with a high prevalence of tuberculosis (TB). OBJECTIVE: To assess the etiology of mediastinal adenopathy in a high TB prevalence setting and to determine the performance of various tests in the diagnosis of tuberculous mediastinal lymphadenitis...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28689684/-ectopic-thymus-a-rare-cause-of-neck-mass-in-children
#4
S Kallel, M Mnejja, M Kessentini, A Ben Said, I Charfeddine, B Hammami, A Ghorbel
INTRODUCTION: Ectopic cervical thymus (ECT) is a rare embryological abnormality in children. It can be revealed by a compressive neck mass mistaken for a malignant tumor. Through a new case of ECT, we review the embryopathogenesis, diagnostic difficulties and therapeutic features. CLINICAL OBSERVATION: A 19-month-old girl presented a right cervical mass that quickly increased in size, causing intermittent dyspnea. The physical examination objectified a 6-cm, soft and compressible, painless right cervical tumefaction, extending from the mastoid area to the ipsilateral supraclavicular fossa...
July 6, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28680616/a-case-of-bilateral-hilar-and-mediastinal-lymphadenopathy-developing-during-treatment-for-mycobacterium-avium-complex
#5
Yumie Yamanaka, Akimasa Sekine, Hideaki Yamakawa, Tomohisa Baba, Koji Okudela, Tamiko Takemura, Takashi Ogura
We report a rare case of an immunocompetent patient with Mycobacterium avium complex (MAC) disease in which bilateral hilar lymphadenopathy developed during anti-MAC treatment. This case indicates that Propionibacterium acnes would be present and might be a cause of sarcoidosis even in patients with MAC.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28642818/nivolumab-as-salvage-treatment-in-a-patient-with-hiv-related-relapsed-refractory-hodgkin-lymphoma-and-liver-failure-with-encephalopathy
#6
Jose D Sandoval-Sus, Francis Mogollon-Duffo, Ankita Patel, Nathan Visweshwar, Damian A Laber, Richard Kim, Michael V Jagal
BACKGROUND: We report the first case to our knowledge of a patient with relapsed/refractory classical hodgkin lymphoma and liver failure with encephalopathy along with human immunodeficiency virus/acquired immunodeficiency syndrome infection, successfully treated with nivolumab without major side effects and encouraging prolonged disease control. CASE PRESENTATION: In December 2015, at the time of the patient's progression from his Hodgkin lymphoma after fourth line treatment, he developed persistent fevers, abdominal distension, jaundice and worsening of his liver function tests...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28634559/malignant-pleural-mesothelioma-with-marked-lymphatic-involvement-a-report-of-two-autopsy-cases
#7
Reiko Ideguchi, Kazuto Ashizawa, Saori Akashi, Michiko Shindo, Kazunori Minami, Toshio Fukuda, Junji Irie, Minoru Fukuda, Masataka Uetani
We herein report two cases of malignant pleural mesothelioma with marked lymphangiosis. The patients included a 68-year-old man and a 67-year-old man who both had a history of exposure to asbestos. Computed tomography (CT) on admission showed pleural effusion with pleural thickening. In both cases, a histopathological examination of the pleura confirmed the diagnosis of epithelioid malignant mesothelioma. They received chemotherapy, but the treatment was only palliative. The chest CT assessments during admission revealed marked pleural effusion and mediastinal lymphadenopathy...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28631863/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-safe-as-it-sounds
#8
REVIEW
Preyas J Vaidya, Mohammed Munavvar, Joerg D Leuppi, Atul C Mehta, Prashant N Chhajed
Real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has earned its place as a standard of care in the evaluation of mediastinal and hilar lymphadenopathy. It is a minimally invasive and a safe procedure with high diagnostic accuracy and efficacy. The increased usage of EBUS-TBNA worldwide has thrown light on its possible complications including death. The complications range from minor to life threatening in few and may occur either early or later in the course after the procedure...
June 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28624157/endoscopic-ultrasound-guided-fine-needle-aspiration-and-cytology-for-differentiating-benign-from-malignant-lymph-nodes
#9
Hussein Okasha, Shaimaa Elkholy, Mohamed Sayed, Ahmed Salman, Yahia Elsherif, Emad El-Gemeie
BACKGROUND AND STUDY AIMS: Intra-abdominal and mediastinal lymphadenopathy are often difficult to diagnose, particularly in the absence of a primary lesion. Endosonography (EUS)-guided fine-needle aspiration and cytology (FNAC) has provided an easy and safe access to these lymph nodes, sparing the use of invasive and costly interventions. The main aim of this study is to assess the specificity, sensitivity, and predictive value of EUS-guided FNAC in the diagnosis of benign and malignant lymph nodes...
June 14, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28621293/yield-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-subcentimetric-lymph-nodes-a-comparison-to-larger-nodes
#10
Narendra S Choudhary, Vijay Bodh, Naveen Kumar, Rajesh Puri, Haimanti Sarin, Mridula Guleria, Tarun Piplani, Sonal Krishan, Rahul Rai, Randhir Sud
BACKGROUND AND OBJECTIVES: Subcentimetric (defined as <1 cm at short axis) lymph nodes are considered benign and there is limited literature on the results of fine needle aspiration (FNA) of these nodes. METHODS: Endoscopic ultrasound (EUS) guided FNA was done on 189 lymph nodes in 166 patients with pyrexia of unknown origin (n = 113) or malignancy (n = 53). Subcentimetric lymph nodes (Group A) were compared to nodes with short axis diameter ≥1 cm (Group B)...
May 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28611639/superior-vena-cava-syndrome-in-a-patient-with-small-cell-lung-cancer-a-case-report
#11
Christina Brzezniak, Bryan Oronsky, Corey A Carter, Bennett Thilagar, Scott Caroen, Karen Zeman
Superior vena cava (SVC) syndrome, a potential oncologic emergency, is closely associated with malignancy and right-sided lung cancer in particular. A case of SVC syndrome presenting with facial swelling, neck distension, and enlarged veins of the upper chest, which developed over a period of 5 weeks in a 46-year-old patient on a clinical trial with small-cell lung cancer, is reported. Computed tomography scan of the chest revealed slight enlargement of a superior conglomerate mediastinal lymphadenopathy and intramural thrombus of the SVC...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28609021/the-critical-role-of-ebus-tbna-cytology-in-the-staging-of-mediastinal-lymph-nodes-in-lung-cancer-patients-a-correlation-study-with-positron-emission-tomography-findings
#12
Mohammed T Lilo, Derek B Allison, Bouchra K Younes, Min Cui, Fred B Askin, Edward Gabrielson, Qing Kay Li
BACKGROUND: The sensitivity and specificity of positron emission tomography (PET) have been significantly improved for the identification of malignancies in recent years; however, it is still necessary to confirm PET findings in a lymph node (LN) by direct tissue sampling. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the most commonly used approach for diagnosing and staging mediastinal LNs, particularly in lung cancer patients with locally advanced disease...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28603654/ideal-conditions-to-perform-ebus-tbna
#13
Barbara Canneto, Giorgio Ferraroli, Giovanni Falezza, Maurizio Valentino Infante
EBUS-TBNA is gaining widespread acceptance as a minimally invasive procedure for mediastinal staging and re-staging of lung cancer, diagnosis of lung tumors adjacent to large airways and characterization of both malignant and benign lymphadenopathy. The aim of this article is to describe the appropriate setting and practical aspects of the procedure that may help at the start of a new EBUS-TBNA program to improve patient safety, comfort and procedural yield according to operator experience, procedure aim, and institutional needs...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603648/color-doppler-sonography-patterns-in-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-of-mediastinal-lymph-nodes
#14
Mario Nosotti, Alessandro Palleschi, Davide Tosi, Paolo Mendogni, Ilaria Righi, Rosaria Carrinola, Lorenzo Rosso
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is commonly used for the pathological diagnosis in patients with mediastinal lymphadenopathy. Even though the accuracy of EBUS-TBNA is considered high, several authors have tried to outline characteristic ultrasound criteria for malignant mediastinal lymph-node identification to maximize this accuracy. Recently, a color-Doppler patterns classification has been proposed by Nakajima to target suspected mediastinal lymph-nodes...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603645/understanding-local-performance-data-for-ebus-tbna-insights-from-an-unselected-case-series-at-a-high-volume-uk-center
#15
Vandana Jeebun, Richard Neil Harrison
BACKGROUND: We reviewed the diagnostic performance of endobronchial ultrasound transbronchial aspiration (EBUS-TBNA) on an unselected large cohort of patients who underwent the procedure in our institution in the past 3 years and to compare against published standards and existing literature. METHODS: All consecutive patients who underwent EBUS from January 2013 to December 2015 were included in the retrospective analysis, with a minimum of 6 months of clinico-radiological follow up...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28600662/mri-in-thoracic-tuberculosis-of-children
#16
Kushaljit Singh Sodhi, Madhurima Sharma, Akshay Kumar Saxena, Joseph L Mathew, Meenu Singh, Niranjan Khandelwal
OBJECTIVE: To explore the utility of lung magnetic resonance imaging (MRI) in children with thoracic tuberculosis (TB). METHODS: This prospective study of forty children (age range of 5 to 15 y) with thoracic TB was approved by the institutional ethics committee. Chest radiograph, lung MRI and computed tomography (CT) scan were performed in all children. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of MRI were calculated and kappa test of agreement was used to determine the strength of agreement between the MRI and CT findings...
June 10, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28584690/unusual-patterns-of-thoracic-metastasis-of-urinary-bladder-carcinoma
#17
Robert Hiensch, Habtamu Belete, Mahsan Rashidfarokhi, Irene Galperin, Fouzia Shakil, Oleg Epelbaum
Urinary bladder carcinoma (UBC) is the ninth most common malignancy and the second most common urological malignancy after prostate cancer in men. Thoracic metastases occur in more than half of those with muscle-invasive disease, and these generally assume the form of multiple solid parenchymal lesions characteristic of hematogenous seeding of the lung. Unusual patterns of thoracic spread of UBC have also been described albeit sporadically in the form of case reports and series. The aim of our case series is to provide illustrations of several atypical patterns of thoracic involvement by UBC such as isolated mediastinal lymphadenopathy, cavitary lung metastases, malignant pleural effusion, endobronchial disease, and pulmonary tumor embolism...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28575247/endoscopic-ultrasound-in-diagnosis-of-esophageal-tuberculosis-10-year-experience-at-a-tertiary-care-center
#18
Y Tang, W Shi, X Sun, W Xi
Definite diagnosis of esophageal tuberculosis (ET) requires isolation of tubercle bacilli, which is challenging in clinical practice. Difficulty in differentiating ET from other esophageal diseases may well result in a delay in diagnosis. The literature on utility of endoscopic ultrasound (EUS) in diagnosis of ET is insufficient. This study aims to evaluate the role of EUS morphology combined with EUS-guided tissue acquisition in the diagnosis of ET. Data of the 35 patients diagnosed with ET from January 2006 to October 2015 were retrospectively analyzed...
August 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28569283/isolated-mediastinal-lymphadenopathy-performance-of-ebus-tbna-in-clinical-practice
#19
P P Velu, P A Reid, W A Wallace, K M Skwarski
Background Isolated mediastinal lymphadenopathy is an increasingly common finding as a result of the increasing use of cross-sectional thoracic imaging. We investigated the performance of endobronchial ultrasoundguided transbronchial needle-aspiration (EBUS-TBNA) in establishing a pathological diagnosis in patients with isolated mediastinal lymphadenopathy. Methods We retrospectively analysed all consecutive EBUS-TBNA examinations performed over a 4-year period at a single tertiary referral centre. Final diagnoses were made using pathology reports, correlated with clinical features and the results of any other investigations...
March 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28553687/malignant-mediastinal-lymphadenopathy-detected-by-endoscopic-ultrasound-and-guided-fine-needle-aspiration-in-patients-with-resectable-pancreaticobiliary-cancer
#20
Praveer Rai, Vinod Kumar, Ram Naval Rao
BACKGROUND: Resection surgery for pancreaticobiliary malignancies carries significant morbidity and mortality. Hence, preoperative assessment to exclude unresectable disease is mandatory. CT abdomen is the primary modality for staging of pancreaticobiliary cancers. However, some patients have malignant mediastinal lymphadenopathy (MML), which may be detected on endoscopic ultrasound (EUS) but not on CT scan. METHODS: We prospectively evaluated 75 consecutive patients (median age 54 years: 44 men) with a diagnosis of resectable pancreaticobiliary cancer (carcinoma gallbladder, carcinoma pancreas, cholangiocarcinoma, or periampullary carcinoma) for the presence of MML using EUS by an experienced endosonographer...
May 29, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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