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Mediastinal lymphadenopathy

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https://www.readbyqxmd.com/read/28106480/radio-pathological-correlation-of-organising-pneumonia-op-a-pictorial-review
#1
Mohammad Zare Mehrjardi, Shahram Kahkouee, Mihan Pourabdollah
Since the description of cryptogenic organising pneumonia (COP) in 1983 by Davison et al. and the subsequent report on bronchiolitis obliterans organising pneumonia (BOOP) by Epler et al., some reports have been published regarding the imaging features of organising pneumonia (OP). In this pictorial review, we aim to describe different manifestations of OP on high-resolution computed tomography (HRCT) accompanied by their histopathological correlations for a better comprehension of the radiological findings pathomechanism...
January 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28101723/role-of-high-resolution-computerized-tomography-chest-in-identifying-tubercular-etiology-in-patients-diagnosed-as-eales-disease
#2
Ranju Kharel Sitaula, Vandana Iyer, Veena Noronha, Parthopratim Dutta Majumder, Jyotirmay Biswas
BACKGROUND: The high resolution computerized tomography of chest is an important diagnostic imaging tool to identify any pulmonary tubercular lesion. It's role in Eales' disease to identify any possible association with pulomonary tuberculosis has not been studied earlier. So, this study was conducted to assess the role of high resolution computerized tomography (HRCT) chest in identifying tuberculous etiology in Eales' disease. RESULTS: It was a retrospective study conducted at a tertiary care eye hospital in South India between January 2009 and October 2014 were included...
December 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28095804/pulmonary-manifestations-in-niemann-pick-type-c-disease-with-mutations-in-npc2-gene-case-report-and-review-of-literature
#3
Jayesh Sheth, Jijo John Joseph, Krati Shah, Mamta Muranjan, Mehul Mistri, Frenny Sheth
BACKGROUND: Niemann-Pick disease type C (NPC) is an inherited metabolic disorder; due to defect in cellular cholesterol trafficking. It is clinically a heterogeneous disease with variable age of onset with multiple organ systems being involved. NPC1 gene is involved in 95% cases where as remaining ~5% cases are linked with NPC2 gene. CASE PRESENTATION: Case-1, a 14-months-old female presented with recurrent respiratory distress, failure to thrive and hepatosplenomegaly...
January 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28073986/does-the-addition-of-postoperative-radiotherapy-to-adjuvant-chemotherapy-offer-any-benefit-in-patients-with-non-small-cell-lung-cancer-and-mediastinal-lymphadenopathy
#4
Georgios Koulaxouzidis, Levon Toufektzian, Leanne Ashrafian, Lukacs Veres
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether the addition of postoperative radiotherapy (PORT) to adjuvant chemotherapy offers any benefit in patients undergoing curative resection for non-small cell lung cancer found to harbour mediastinal lymphadenopathy. A total of 77 papers were identified using the reported search, of which 11 represented the best evidence to answer the clinical question. Only studies reporting on survival data of patients receiving adjuvant chemotherapy with and without PORT were included in this analysis...
January 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28066671/current-advances-of-endobronchial-ultrasonography-in-the-diagnosis-and-staging-of-lung-cancer
#5
REVIEW
Chao-Chi Ho, Ching-Kai Lin, Ching-Yao Yang, Lih-Yu Chang, Shu-Yung Lin, Chong-Jen Yu
The diagnosis and staging of patients with lung cancer has relied on tissue sampling. Endobronchial ultrasound (EBUS) is a minimally invasive procedure for the rapid and safe acquisition of tissue and can be done easily and repeatedly. EBUS transbronchial needle aspiration (TBNA) is now the standard for diagnosis of mediastinal and hilar lymphadenopathy and should be considered in patients who have a high probability of lymph node metastases without systemic involvement. EBUS also provides guidance for biopsy of peripheral lung lesions...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28054531/diagnostic-value-of-core-biopsy-histology-and-cytology-sampling-of-mediastinal-lymph-nodes-using-21-gauge-ebus-tbna-needle
#6
Preyas J Vaidya, Avinandan Saha, Arvind H Kate, Kamlesh Pandey, Vinod B Chavhan, Joerg D Leuppi, Prashant N Chhajed
INTRODUCTION: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the initial modality of choice in sampling mediastinal lymphadenopathy. It is possible to obtain both cytological and histological samples using both 21-gauge and 22-gauge EBUS-TBNA needles. The current study was undertaken to compare the diagnostic yield of cytology and histology samples obtained by the same EBUS-TBNA 21-gauge needle. PATIENTS AND METHODS: One hundred sixty-six consecutive patients who underwent EBUS-TBNA with a 21-gauge EBUS-TBNA needle over a period of 3 years were included in this retrospective analysis...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28052172/role-of-transbronchial-needle-aspiration-conventional-and-ebus-guided-in-the-diagnosis-of-histoplasmosis-in-patients-presenting-with-mediastinal-lymphadenopathy
#7
Amik Sodhi, Rodjawan Supakul, George W Williams, Elizabeth A Tolley, Arthur S Headley, Luis C Murillo, Dipen Kadaria
OBJECTIVES: The superior performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis and staging of malignancy has been demonstrated, with some investigators suggesting the same for sarcoidosis. The role of EBUS-TBNA in the diagnosis of histoplasmosis is not clear, however. In this study we estimate the diagnostic yield of conventional TBNA (cTBNA) and EBUS-TBNA for the diagnosis of histoplasmosis in patients with mediastinal lymphadenopathy...
January 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28044305/clinicopathological-analysis-of-mediastinal-masses-a-mixed-bag-of-non-neoplastic-and-neoplastic-etiologies
#8
Preeti Sharma, Vidya Jha, Naveen Kumar, Rohit Kumar, Ashish Mandal
OBJECTIVE: The mediastinum is the central portion of the thoracic cavity, housing numerous organs and harbouring a mixed bag of non-neoplastic and neoplastic lesions. Accurate diagnosis is essential owing to the widely variable therapeutic and prognostic implications. MATERIAL AND METHOD: Cases of mediastinal masses were retrospectively reviewed from January 2011 till January 2016. Clinico-radiological records of these cases were retrieved. Fine needle aspiration cytology (FNAC) was performed wherever feasible...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28043582/mediastinal-lymphadenopathy-in-pediatric-tuberculosis-in-computed-tomography-scan
#9
Payam Mehrain, Amin Momeni Moghaddam, Elham Tavakol, Afshin Amini, Mehrdad Moghimi, Ali Kabir, Ali Akbar Velayati
BACKGROUND/OBJECTIVES: Pediatric tuberculosis is usually a primary infection presenting mainly as mediastinal or hilar adenopathy in computed tomography (CT) scan. In this study, we study the distribution and other CT scan characteristics of mediastinal lymphadenopathy in childhood tuberculosis. METHODS: Chest CT scans of 75 cases of pediatric tuberculosis at Masih Daneshvari Hospital in Tehran, Iran, from 2009 to 2013 were studied regarding characteristics of mediastinal lymphadenopathy...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043581/common-features-of-tuberculosis-and-sarcoidosis
#10
Esmaeil Mortaz, Mohammad Reza Masjedi, Atefeh Abedini, Soheila Matroodi, Arda Kiani, Dina Soroush, Ian M Adcock
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Despite the availability of novel therapeutic approaches, TB is considered as one of the leading causes of death due to infectious diseases worldwide. Alveolar macrophages are the first line of defense against M. tuberculosis; they ingest and sequester the bacilli within granulomatous structures. Control and resolution of the infection requires activated T lymphocytes as well as Th1 cytokines. There are two forms of TB: active TB and latent TB...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27999517/sarcoid-uveitis-a-look-beyond-the-eyes
#11
Daniel Lemor, David B Lazar, W Brooks Emory, Jonathan D Nussdorf
BACKGROUND: Bilateral acute uveitis can cause significant morbidity, and a complete workup is often warranted. This report illustrates a case of sarcoid uveitis definitively diagnosed by skin biopsy in a patient with red tattoo ink. CASE REPORT: A 40-year-old African American male presented with bilateral photophobia and intraocular pressures of 26 mmHg in both eyes, 1+ grade cell and flare in both eyes, and granulomatous (mutton fat) keratic precipitates in both eyes...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27993826/minimal-change-disease-associated-with-malignant-pleural-mesothelioma-case-report-and-review-of-the-literature
#12
Halil Yildiz, Stoian Ioana Andreea, Delphine Hoton, Jean Cyr Yombi
A 77-year-old man with a history of asbestos exposure was admitted to our internal medicine division for generalised weakness, fatigue, loss of weight, night sweats and difficulty for breathing since 3 months. Clinical examination revealed left fine crackles and bilateral leg oedema. Blood test showed elevated C reactive protein level at 142 mg/L, lactate dehydrogenase level at 421 UI, creatinine level at 5.75 mg/dL. Serum albumin level at 30 g/L, urinalysis showed significant proteinuria at 6.4 g/L...
December 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27933567/impact-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-prospective-liver-transplant-recipients-with-hepatocellular-carcinoma-and-lymphadenopathy
#13
Narendra S Choudhary, Rajesh Puri, Sanjiv Saigal, Prashant Bhangui, Neeraj Saraf, Vinit Shah, Mukesh Nasa, Haimanti Sarin, Mridula Guleria, Randhir Sud, Arvinder S Soin
BACKGROUND: Diagnosis of metastatic disease is important in patients with cirrhosis and hepatocellular carcinoma (HCC) to prevent futile liver transplantation. Some of these patients have metastatic lymphadenopathy; however, it is difficult to perform percutaneous fine-needle aspiration due to presence of collateral and anatomic location. Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) of lymph nodes offers several advantages like real-time vision, proximity to target, and avoidance of collaterals...
November 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27923223/intestinal-pneumatosis-associated-with-tuberculosis-after-allogeneic-hematopoietic-stem-cell-transplantation
#14
Vivek Venkataramani, Ali Seif Amir Hosseini, Marco H Schulze, Lorenz Trümper, Gerald Wulf, Ulrike Bacher, Wolfram Jung
Pneumatosis intestinalis (PI), defined as intestinal intra- and extramural gas accumulation, is a rare radiographic finding in conditions of intestinal wall damage of varied etiology. Here, we report on a 56-year-old female with multiple myeloma who presented with undulating fever, fluctuating abdominal symptoms, and a distended abdomen 5 months after allogeneic hematopoietic stem cell transplantation (HSCT). Abdominal X-ray and CT scan documented PI with gas accumulation both in the intestinal and colonic bowel walls...
2017: Acta Haematologica
https://www.readbyqxmd.com/read/27900088/favorable-control-of-advanced-colon-adenocarcinoma-with-severe-bone-marrow-metastasis-a-case-report
#15
Fumiyasu Hanamura, Yoshihiro Shibata, Tsuyoshi Shirakawa, Miyuki Kuwayama, Hisanobu Oda, Hiroshi Ariyama, Kenichi Taguchi, Taito Esaki, Eishi Baba
Colorectal cancer (CRC) has a propensity to metastasize to the liver, lungs and regional abdominal lymph nodes, but rarely to the bone marrow. A 60-year-old man presented to the National Hospital Organization Kyushu Cancer Center with a 4-week history of persistent lower back pain, anorexia and difficulty defecating. Complete blood count revealed severe thrombocytopenia and erythroblastosis, suggesting a hematological malignancy. However, the bone marrow examination demonstrated involvement by a moderately to poorly differentiated adenocarcinoma, but no hematopoietic abnormalities...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27895343/cervical-mediastinoscopy-in-the-diagnosis-of-lymphadenopathy-in-south-asia
#16
Sulaiman Bashir Hasan, Fazal Wahab Khan, Shiraz Hashmi, Ahsan Ehtesham, Rizwana Ahmed Magsi, Syed Shahabuddin
We planned to determine the clinical utility and safety of mediastinoscopy in the pathologic diagnosis of mediastinal lymphadenopathy and to determine disease patterns in a tertiary care setting in Karachi. The retrospective review comprised record of patients who underwent mediastinoscopy over 25 years between July, 1990 and August, 2015. Of the 122 patients, records were complete for 88(72%). Mean age was 42.5±12.9 years and 55(62.5%) were male. Overall, 60(68.2%) patients had benign inflammatory diseases; 25 (28...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27893684/ct-findings-of-small-cell-lung-carcinoma-can-recognizable-features-be-found
#17
Dongjun Lee, Ji Young Rho, Seunghun Kang, Koun Joy Yoo, Hye Jeong Choi
The purpose of this study was to clarify the recognizable computed tomography (CT) features of small cell lung carcinoma (SCLC).Contrast enhanced CT scans were reviewed retrospectively for mass location, mediastinal extension, and other concomitant findings in 142 patients with pathologically proven SCLC. SCLC was classified into hilar mass only (type I), hilar mass with ipsilateral mediastinal extension (type II), hilar mass with bilateral mediastinal extension (type III), and peripheral mass (type IV). When mediastinal lymphadenopathy (m-LAP) was indistinguishable from a hilar mass, we defined it as a mediastinal conglomerate mass (m-CM)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890996/dry-cough-in-a-middle-aged-man
#18
Sheetu Singh, Nishtha Singh, Arpita Jindal
Cough is often a distressing feature and may be caused due to varied reasons. A 39-year-old man presented with complaints of cough and had significant pigeon exposure. His chest X-ray revealed mediastinal enlargement and computed tomography chest revealed air trapping and mediastinal lymphadenopathy. Both endobronchial and transbronchial biopsies revealed granulomas. Thus, the patient was diagnosed as a case of sarcoidosis and started on steroids. Hypersensitivity pneumonitis may often mimic sarcoidosis; however, the presence of endobronchial granulomas will diagnose the latter condition...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27882677/utility-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-diagnosing-non-specific-inflammatory-intrathorcacic-lymphadenitis
#19
Huizhen Yang, Shenglan Wang, Jiajun Teng, Baohui Han, Jiayuan Sun
BACKGROUND AND OBJECTIVE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a minimally invasive technique for diagnosing intrathoracic malignancies and some benignancies; however, there are no data available on the utility of EBUS-TBNA for the diagnosis of non-specific inflammatory intrathoracic lymphadenitis. METHODS: A prospective analysis was performed from 104 patients with enlarged lymphadenopathy suspected of non-specific lymphadenitis referred for EBUS-TBNA between October 2009 and March 2012...
November 7, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27870565/concurrent-chemotherapy-and-radiation-therapy-for-inoperable-locally-advanced-non-small-cell-lung-cancer
#20
Kenneth E Rosenzweig, Jorge E Gomez
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
January 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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