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Mediastinal lymphadenopathy

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https://www.readbyqxmd.com/read/29229107/clinical-characterization-of-52-patients-with-immunoglobulin-g4-related-disease-in-a-single-tertiary-center-in-japan-special-reference-to-lung-disease-in-thoracic-high-resolution-computed-tomography
#1
Takeshi Saraya, Kosuke Ohkuma, Masachika Fujiwara, Chika Miyaoka, Shoko Wada, Takayasu Watanabe, Sunao Mikura, Manami Inoue, Miku Oda, Mitsuru Sada, Yukari Ogawa, Kojiro Honda, Masaki Tamura, Takuma Yokoyama, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa
BACKGROUND: Immunoglobulin G4-related disease (IgG4-RD) is a rare multi-organ disorder. Physicians rarely encounter patients with IgG4-RD and its range of symptoms. METHODS: To elucidate the clinical characterization of IgG4-RD, along with the clinical significance of lung involvement, we retrospectively reviewed the medical records of patients who satisfied the comprehensive diagnostic criteria for IgG4-RD. RESULTS: We identified 52 patients with IgG4-RD...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29229083/thoracic-involvement-in-igg4-related-disease-in-a-uk-based-patient-cohort
#2
John P Corcoran, Emma L Culver, Rebekah M Anstey, Ambika Talwar, Charis D Manganis, Tamsin N Cargill, Robert J Hallifax, Ioannis Psallidas, Najib M Rahman, Eleanor Barnes
IgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder with classical histopathological findings, often in the context of elevated serum IgG4 levels. The thoracic manifestations of IgG4-RD are numerous and can mimic several common and better known conditions. The objective of this study was to outline the frequency and nature of thoracic involvement in a prospective cohort of IgG4-RD patients who met defined diagnostic criteria. Over 40% of IgG4-RD patients had clinicoradiological and/or histological evidence of thoracic involvement, predominantly mediastinal lymphadenopathy, the majority associated with multi-system disease outside the chest...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29224303/-atypical-computed-tomography-manifestations-of-thoracic-sarcoidosis
#3
J Ma, Y C Wang, X W Sun, C Y Sun
Objective: This study evaluated the atypical computed tomography (CT) manifestations of thoracic sarcoidosis. Methods: Medical data of 190 patients with thoracic sarcoidosis were retrospectively reviewed. Results: The atypical CT manifestations of thoracic sarcoidosis observed were unilateral hilar lymphadenopathy with or without mediastinal lymphadenopathy(n=12, 6.3%), mediastinal lymphadenopathy without hilar lymphadenopathy(n=9, 4.7%), patchy consolidation (n=23, 12.1%), sarcoid galaxy sign (n=22, 11.6%), reversed halo sign (n=1, 0...
December 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29201483/purulent-appearing-material-in-an-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-of-mediastinal-lymph-node-a-diagnostic-challenge
#4
Damaris Pena, Gilda Diaz-Fuentes, Sindhaghatta Venkatram
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has increasingly been performed for the diagnosis and staging of thoracic malignancies. Findings of a necrotic lymph node raise concern for infectious process and malignancy. A hypoechoic area on ultrasound/EBUS within a lymph node without blood flow is suggestive of pathologies like infections or malignancy. Inspection of the fluid could suggest a diagnosis; clear aspirates usually suggest bronchogenic or mediastinal cysts and purulent material suggests abscesses or necrotic lymph nodes...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29191132/severe-disseminated-necrotizing-and-granulomatous-lymphadenitis-and-encephalitis-in-a-dog-due-to-sporotrichum-pruinosum-teleomorph-phanerochaete-chrysosporium
#5
Drew R Magstadt, Amanda J Fales-Williams, Jean-Sébastien Palerme, Heather Flaherty, Tracy Lindquist, Kristina G Miles
A 9-year-old female mixed breed dog presented for an acute onset of anorexia, vomiting, and cough. Initial examination and diagnostics revealed a large multilobular cranial mediastinal mass with unidentified fungal organisms on cytology. The disease progressed in spite of therapy until the dog was euthanized 8 months later. Gross necropsy findings were a large multilobular intrathoracic mass, mild pleuritis, and generalized lymphadenopathy. Histologic evaluation showed granulomatous inflammation and necrosis with numerous 20- to 70-micron, periodic acid-Schiff- and Gomori methenamine silver-positive spherules effacing lymph node parenchyma, as well as severe inflammation within the midbrain...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29186261/cutaneous-sarcoidosis-and-secondary-open-angle-glaucoma-in-a-patient-case-report-and-literature-review
#6
Qiancheng Deng, Shu Ding, Shengbo Yang, JinHua Huang
The current report presents the case of a 41-year-old male patient with a two-month history of asthenopia and plaques in the frontotemporal region. Computed tomography revealed bilateral hilar and mediastinal lymphadenopathy. Ophthalmological examination showed elevated intraocular pressure. Skin biopsy demonstrated aa dermal inflammatory infiltrate composed mainly of epithelioid cells and a few multinucleated giant cells, but no obvious lymphocytes. Findings of thorough physical examinations and auxiliary examinations suggested the presence of cutaneous sarcoidosis and secondary open-angle glaucoma...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29157067/role-of-endoscopic-ultrasound-in-the-management-of-tubercular-uveitis
#7
Deepa Sharma, Manisha Agarwal, Vikas Singla, Vivek Jha, Ankita Shrivastav
PURPOSE: To evaluate the role and safety of endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) in patients of tubercular uveitis. DESIGN: Interventional case series Methods: Thirty patients suspected of tubercular uveitis that underwent EUS-FNAC were enrolled in the study. The patient details recorded were age, gender, systemic history, ocular complaints and clinical manifestations. The details of the investigations - skin test, X-Ray chest, CECT (contrast enhanced computed tomography) of chest and findings on EUS-FNAC were also recorded...
November 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29154972/impact-of-rapid-on-site-cytological-evaluation-rose-on-the-diagnostic-yield-of-transbronchial-needle-aspiration-during-mediastinal-lymph-node-sampling-systematic-review-and-meta-analysis
#8
Inderpaul Singh Sehgal, Sahajal Dhooria, Ashutosh Nath Aggarwal, Ritesh Agarwal
BACKGROUND: Whether the use of rapid onsite cytological evaluation (ROSE) increases the diagnostic yield of transbronchial needle aspiration (TBNA) remains unclear. Herein, we perform a systematic review of studies describing the utility of ROSE in subjects undergoing TBNA. METHODS: Systematic review of PubMed, EmBase and Scopus databases for RCTs investigating the diagnostic yield of conventional TBNA (c-TBNA) or endobronchial ultrasound (EBUS)-TBNA, with or without ROSE, in subjects with mediastinal lymphadenopathy...
November 15, 2017: Chest
https://www.readbyqxmd.com/read/29151508/cardiac-sarcoidosis-presenting-as-acute-progressive-heart-failure-with-abdominal-lymphadenopathy
#9
Satoshi Oka, Ken Umetani, Tomoko Harama, Takuya Shimizu, Aritaka Makino, Keita Sano, Masahiko Nakamura
A 77-year-old Japanese woman presented with asymptomatic abdominal lymphadenopathy. Soluble interleukin-2 receptor (sIL2R) and angiotensin-converting enzyme (ACE) levels were elevated, and a pathological examination of lymph-node biopsies revealed non-caseating granulomas, which was consistent with sarcoidosis. Fluorodeoxyglucose-positron emission tomography did not show a clear accumulation in the mediastinal lymph-nodes or heart. Five months later, she presented with acute progressive heart failure that was refractory to conventional treatment...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29147774/assessment-of-mediastinal-lymph-node-size-in-pneumococcal-pneumonia-with-bacteremia
#10
Amit Chopra, Aakash Modi, Haroon Chaudhry, Recai Yucel, Neha Rane, John Fantauzzi, Frederic J Hellwitz, Marc A Judson
INTRODUCTION: The significance of mediastinal lymphadenopathy in bacterial pneumonia is unclear. METHODS: We performed a retrospective analysis of mediastinal lymph node size determined by chest CT in patients with bacteremic pneumococcal pneumonia. All patients who had positive blood cultures for streptococcus pneumonia over an 11-year period and had a chest CT scan (index CT) within 2 weeks of the positive blood culture were included in the study. Two thoracic radiologists and one pulmonologist independently examined the index CT plus any chest CT scans performed prior (pre-CT) or after (post-CT) the bacteremic episode...
November 16, 2017: Lung
https://www.readbyqxmd.com/read/29125330/benign-and-malignant-enlarged-chest-nodes-staging-by-diffusion-weighted-mri-an-alternative-to-mediastinoscopy
#11
Monica Sigovan, Pia Akl, Caroline Mesmann, Francois Tronc, Salim Si Mohamed, Philippe Douek, Loic Boussel
OBJECTIVE: To evaluate the accuracy of diffusion weighted MRI with background suppression (DWIBS) in differentiating between malignant and benign mediastinal lymph-nodes. METHODS: Consecutive patients with enlarged mediastinal lymph-nodes underwent MRI DWIBS within 10 days prior to mediastinoscopy. Relative contrast ratios (RCR) were computed on b800 and apparent diffusion coefficient (ADC) maps by dividing the node signal with the chest muscle signal, using manually drawn regions of interest (ROIs) by radiologists, blinded to pathology...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29105350/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-with-the-flexible-19-gauge-needle
#12
Rocco Trisolini, Filippo Natali, Marco Ferrari, Vanina Livi, Daniela Paioli, Micaela Romagnoli, Alessandra Cancellieri
INTRODUCTION AND OBJECTIVES: Endosonography has become standard of care in the diagnostic work-up of mediastinal lymphadenopathy and peribronchial lung lesions, but its success rate in some specific settings/conditions may be hampered by limited needle flexibility and size. We report on our initial experience with the 19G Flex needle, characterized by larger size and greater flexibility as compared with the currently available cytology needles. METHODS: Retrospective review of prospectively collected data on the first 13 consecutive patients submitted to endosonography with the 19G Flex needle...
November 4, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29098999/tracheobronchial-puncture-site-nodular-reaction-tpnr-following-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-systematic-review-of-case-reports
#13
REVIEW
Karan Madan, Pavan Tiwari, Sudheer Arava, Vijay Hadda, Anant Mohan, Randeep Guleria
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and efficacious diagnostic modality for lung cancer staging and evaluation of undiagnosed mediastinal lymphadenopathy. Procedure-related complications are uncommon. We herein report an infrequently described phenomenon following EBUS-TBNA in which two patients developed nodular granulation tissue at the tracheobronchial puncture site. On systematic review, we found description of such phenomena by terminologies such as endobronchial inflammatory polyp, granuloma, and endobronchial mass...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29098128/hot-tub-lung-a-diagnostic-challenge
#14
Hassaan Yasin, William E Mangano, Paras Malhotra, Ali Farooq, Hesham Mohamed
Hot tub lung (HTL) is a granulomatous lung disease thought to occur as a result of a hypersensitivity response to non-tuberculous mycobacteria (NTM). Typical radiographic findings are diffuse micronodular and/or ground glass opacities. We report an interesting case of HTL that presented with unique radiographic features, making its diagnosis a predicament. A 56-year-old immunocompetent female with chronic dyspnea and dry cough was found to have subcentimeter cavitary nodules, predominantly in the upper lung zones...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29090653/tuberculous-pyelonephritis-in-children-three-case-reports
#15
Nimisha Arora, Abhijeet Saha, Manpreet Kaur
Tuberculous pyelonephritis is rare in children; three case reports are presented. Case 1 was an 11-year-old girl with a previous history of pulmonary tuberculosis who presented with flank pain and fever for 10 days. An ultrasound suggested focal pyelonephritis, and a contrast-enhanced computed tomography (CECT) scan demonstrated acute focal pyelonephritis and a perinephric collection. Mycobacterium tuberculosis was cultured in the urine. She responded well to anti-tuberculous treatment (ATT). Case 2 was a 13-year-old boy who presented with fever, haematuria, burning micturition, proteinuria (3+) and cervical lymphadenopathy...
November 1, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29089687/follow-up-chest-radiographic-findings-in-patients-with-mers-cov-after-recovery
#16
Karuna M Das, Edward Y Lee, Rajvir Singh, Mushira A Enani, Khalid Al Dossari, Klaus Van Gorkom, Sven G Larsson, Ruth D Langer
PURPOSE: To evaluate the follow-up chest radiographic findings in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) who were discharged from the hospital following improved clinical symptoms. MATERIALS AND METHODS: Thirty-six consecutive patients (9 men, 27 women; age range 21-73 years, mean ± SD 42.5 ± 14.5 years) with confirmed MERS-CoV underwent follow-up chest radiographs after recovery from MERS-CoV. The 36 chest radiographs were obtained at 32 to 230 days with a median follow-up of 43 days...
July 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29076937/endobronchial-ultrasound-transbronchial-needle-aspiration-for-the-diagnosis-of-lymphoma
#17
Sheetal Gandotra, Travis Dotson, Zanetta Lamar, Christina Bellinger
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) presents a minimally invasive way to evaluate abnormal mediastinal and hilar adenopathy. Although EBUS has been established as an effective modality to diagnose lung cancer, its sensitivity for the diagnosis of lymphoma has been demonstrated to be lower. Because of these lower yields uncertainty persists about the ability of EBUS-TBNA to reliably diagnose lymphoma and questions remain regarding the utility of EBUS-TBNA as a first-line biopsy modality for patients suspected of having lymphoma...
October 25, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29071277/ebus-tbna-in-pet-positive-lymphadenopathies-in-treated-cancer-patients
#18
Juliana Guarize, Monica Casiraghi, Stefano Donghi, Chiara Casadio, Cristina Diotti, Niccolò Filippi, Clementina Di Tonno, Valeria Midolo, Patrick Maisonneuve, Daniela Brambilla, Chiara Maria Grana, Francesco Petrella, Lorenzo Spaggiari
Mediastinal lymph node enlargement is common in the follow-up of patients with previously treated malignancies. The aim of this study is to assess the role of endobronchial ultrasound (EBUS) transbronchial needle aspiration (TBNA) for cyto-histological evaluation of positron emission tomography with (18)fluorodeoxyglucose (PET) positive mediastinal and hilar lymph nodes developed in patients with previous malignancies. All EBUS-TBNA cases performed from January 2012 to May 2016 were retrospective reviewed. Results of EBUS-TBNA in patients with mediastinal and/or hilar lymphadenopathies were analysed...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29066643/metastatic-meningioma-a-rare-cause-of-mediastinal-lymphadenopathy
#19
Hannah Louise Bond, Emma Maeve O'Hare, James Elliot Garvican, Fiona Grace Minear
No abstract text is available yet for this article.
October 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29052772/imaging-of-thoracic-tuberculosis-in-children-current-and-future-directions
#20
REVIEW
Kushaljit Singh Sodhi, Ashu S Bhalla, Nasreen Mahomed, Bernard F Laya
Tuberculosis continues to be an important cause of morbidity and mortality worldwide. It is the leading cause of infection-related deaths worldwide. Children are amongst the high-risk groups for developing tuberculosis and often pose a challenge to the clinicians in making a definitive diagnosis. The newly released global tuberculosis report from World Health Organization reveals a 50% increase in fatality from tuberculosis in children. Significantly, diagnostic and treatment algorithms of tuberculosis for children differ from those of adults...
September 2017: Pediatric Radiology
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