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Mediastinal lymphadenopathy

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https://www.readbyqxmd.com/read/28634559/malignant-pleural-mesothelioma-with-marked-lymphatic-involvement-a-report-of-two-autopsy-cases
#1
Reiko Ideguchi, Kazuto Ashizawa, Saori Akashi, Michiko Shindo, Kazunori Minami, Toshio Fukuda, Junji Irie, Minoru Fukuda, Masataka Uetani
We herein report two cases of malignant pleural mesothelioma with marked lymphangiosis. The patients included a 68-year-old man and a 67-year-old man who both had a history of exposure to asbestos. Computed tomography (CT) on admission showed pleural effusion with pleural thickening. In both cases, a histopathological examination of the pleura confirmed the diagnosis of epithelioid malignant mesothelioma. They received chemotherapy, but the treatment was only palliative. The chest CT assessments during admission revealed marked pleural effusion and mediastinal lymphadenopathy...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28631863/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-safe-as-it-sounds
#2
REVIEW
Preyas J Vaidya, Mohammed Munavvar, Joerg D Leuppi, Atul C Mehta, Prashant N Chhajed
Real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has earned its place as a standard of care in the evaluation of mediastinal and hilar lymphadenopathy. It is a minimally invasive and a safe procedure with high diagnostic accuracy and efficacy. The increased usage of EBUS-TBNA worldwide has thrown light on its possible complications including death. The complications range from minor to life threatening in few and may occur either early or later in the course after the procedure...
June 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28624157/endoscopic-ultrasound-guided-fine-needle-aspiration-and-cytology-for-differentiating-benign-from-malignant-lymph-nodes
#3
Hussein Okasha, Shaimaa Elkholy, Mohamed Sayed, Ahmed Salman, Yahia Elsherif, Emad El-Gemeie
BACKGROUND AND STUDY AIMS: Intra-abdominal and mediastinal lymphadenopathy are often difficult to diagnose, particularly in the absence of a primary lesion. Endosonography (EUS)-guided fine-needle aspiration and cytology (FNAC) has provided an easy and safe access to these lymph nodes, sparing the use of invasive and costly interventions. The main aim of this study is to assess the specificity, sensitivity, and predictive value of EUS-guided FNAC in the diagnosis of benign and malignant lymph nodes...
June 14, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28621293/yield-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-subcentimetric-lymph-nodes-a-comparison-to-larger-nodes
#4
Narendra S Choudhary, Vijay Bodh, Naveen Kumar, Rajesh Puri, Haimanti Sarin, Mridula Guleria, Tarun Piplani, Sonal Krishan, Rahul Rai, Randhir Sud
BACKGROUND AND OBJECTIVES: Subcentimetric (defined as <1 cm at short axis) lymph nodes are considered benign and there is limited literature on the results of fine needle aspiration (FNA) of these nodes. METHODS: Endoscopic ultrasound (EUS) guided FNA was done on 189 lymph nodes in 166 patients with pyrexia of unknown origin (n = 113) or malignancy (n = 53). Subcentimetric lymph nodes (Group A) were compared to nodes with short axis diameter ≥1 cm (Group B)...
May 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28611639/superior-vena-cava-syndrome-in-a-patient-with-small-cell-lung-cancer-a-case-report
#5
Christina Brzezniak, Bryan Oronsky, Corey A Carter, Bennett Thilagar, Scott Caroen, Karen Zeman
Superior vena cava (SVC) syndrome, a potential oncologic emergency, is closely associated with malignancy and right-sided lung cancer in particular. A case of SVC syndrome presenting with facial swelling, neck distension, and enlarged veins of the upper chest, which developed over a period of 5 weeks in a 46-year-old patient on a clinical trial with small-cell lung cancer, is reported. Computed tomography scan of the chest revealed slight enlargement of a superior conglomerate mediastinal lymphadenopathy and intramural thrombus of the SVC...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28609021/the-critical-role-of-ebus-tbna-cytology-in-the-staging-of-mediastinal-lymph-nodes-in-lung-cancer-patients-a-correlation-study-with-positron-emission-tomography-findings
#6
Mohammed T Lilo, Derek B Allison, Bouchra K Younes, Min Cui, Fred B Askin, Edward Gabrielson, Qing Kay Li
BACKGROUND: The sensitivity and specificity of positron emission tomography (PET) have been significantly improved for the identification of malignancies in recent years; however, it is still necessary to confirm PET findings in a lymph node (LN) by direct tissue sampling. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the most commonly used approach for diagnosing and staging mediastinal LNs, particularly in lung cancer patients with locally advanced disease...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28603654/ideal-conditions-to-perform-ebus-tbna
#7
Barbara Canneto, Giorgio Ferraroli, Giovanni Falezza, Maurizio Valentino Infante
EBUS-TBNA is gaining widespread acceptance as a minimally invasive procedure for mediastinal staging and re-staging of lung cancer, diagnosis of lung tumors adjacent to large airways and characterization of both malignant and benign lymphadenopathy. The aim of this article is to describe the appropriate setting and practical aspects of the procedure that may help at the start of a new EBUS-TBNA program to improve patient safety, comfort and procedural yield according to operator experience, procedure aim, and institutional needs...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603648/color-doppler-sonography-patterns-in-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-of-mediastinal-lymph-nodes
#8
Mario Nosotti, Alessandro Palleschi, Davide Tosi, Paolo Mendogni, Ilaria Righi, Rosaria Carrinola, Lorenzo Rosso
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is commonly used for the pathological diagnosis in patients with mediastinal lymphadenopathy. Even though the accuracy of EBUS-TBNA is considered high, several authors have tried to outline characteristic ultrasound criteria for malignant mediastinal lymph-node identification to maximize this accuracy. Recently, a color-Doppler patterns classification has been proposed by Nakajima to target suspected mediastinal lymph-nodes...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603645/understanding-local-performance-data-for-ebus-tbna-insights-from-an-unselected-case-series-at-a-high-volume-uk-center
#9
Vandana Jeebun, Richard Neil Harrison
BACKGROUND: We reviewed the diagnostic performance of endobronchial ultrasound transbronchial aspiration (EBUS-TBNA) on an unselected large cohort of patients who underwent the procedure in our institution in the past 3 years and to compare against published standards and existing literature. METHODS: All consecutive patients who underwent EBUS from January 2013 to December 2015 were included in the retrospective analysis, with a minimum of 6 months of clinico-radiological follow up...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28600662/mri-in-thoracic-tuberculosis-of-children
#10
Kushaljit Singh Sodhi, Madhurima Sharma, Akshay Kumar Saxena, Joseph L Mathew, Meenu Singh, Niranjan Khandelwal
OBJECTIVE: To explore the utility of lung magnetic resonance imaging (MRI) in children with thoracic tuberculosis (TB). METHODS: This prospective study of forty children (age range of 5 to 15 y) with thoracic TB was approved by the institutional ethics committee. Chest radiograph, lung MRI and computed tomography (CT) scan were performed in all children. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of MRI were calculated and kappa test of agreement was used to determine the strength of agreement between the MRI and CT findings...
June 10, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28584690/unusual-patterns-of-thoracic-metastasis-of-urinary-bladder-carcinoma
#11
Robert Hiensch, Habtamu Belete, Mahsan Rashidfarokhi, Irene Galperin, Fouzia Shakil, Oleg Epelbaum
Urinary bladder carcinoma (UBC) is the ninth most common malignancy and the second most common urological malignancy after prostate cancer in men. Thoracic metastases occur in more than half of those with muscle-invasive disease, and these generally assume the form of multiple solid parenchymal lesions characteristic of hematogenous seeding of the lung. Unusual patterns of thoracic spread of UBC have also been described albeit sporadically in the form of case reports and series. The aim of our case series is to provide illustrations of several atypical patterns of thoracic involvement by UBC such as isolated mediastinal lymphadenopathy, cavitary lung metastases, malignant pleural effusion, endobronchial disease, and pulmonary tumor embolism...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28575247/endoscopic-ultrasound-in-diagnosis-of-esophageal-tuberculosis-10-year-experience-at-a-tertiary-care-center
#12
Y Tang, W Shi, X Sun, W Xi
Definite diagnosis of esophageal tuberculosis (ET) requires isolation of tubercle bacilli, which is challenging in clinical practice. Difficulty in differentiating ET from other esophageal diseases may well result in a delay in diagnosis. The literature on utility of endoscopic ultrasound (EUS) in diagnosis of ET is insufficient. This study aims to evaluate the role of EUS morphology combined with EUS-guided tissue acquisition in the diagnosis of ET. Data of the 35 patients diagnosed with ET from January 2006 to October 2015 were retrospectively analyzed...
August 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28569283/isolated-mediastinal-lymphadenopathy-performance-of-ebus-tbna-in-clinical-practice
#13
P P Velu, P A Reid, W A Wallace, K M Skwarski
Background Isolated mediastinal lymphadenopathy is an increasingly common finding as a result of the increasing use of cross-sectional thoracic imaging. We investigated the performance of endobronchial ultrasoundguided transbronchial needle-aspiration (EBUS-TBNA) in establishing a pathological diagnosis in patients with isolated mediastinal lymphadenopathy. Methods We retrospectively analysed all consecutive EBUS-TBNA examinations performed over a 4-year period at a single tertiary referral centre. Final diagnoses were made using pathology reports, correlated with clinical features and the results of any other investigations...
March 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28553687/malignant-mediastinal-lymphadenopathy-detected-by-endoscopic-ultrasound-and-guided-fine-needle-aspiration-in-patients-with-resectable-pancreaticobiliary-cancer
#14
Praveer Rai, Vinod Kumar, Ram Naval Rao
BACKGROUND: Resection surgery for pancreaticobiliary malignancies carries significant morbidity and mortality. Hence, preoperative assessment to exclude unresectable disease is mandatory. CT abdomen is the primary modality for staging of pancreaticobiliary cancers. However, some patients have malignant mediastinal lymphadenopathy (MML), which may be detected on endoscopic ultrasound (EUS) but not on CT scan. METHODS: We prospectively evaluated 75 consecutive patients (median age 54 years: 44 men) with a diagnosis of resectable pancreaticobiliary cancer (carcinoma gallbladder, carcinoma pancreas, cholangiocarcinoma, or periampullary carcinoma) for the presence of MML using EUS by an experienced endosonographer...
May 29, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28552534/an-epstein-barr-virus-positive-classical-hodgkin-lymphoma-with-exclusive-sinusoidal-growth-pattern-an-unusual-morphologic-variant
#15
Pu Su, Rachel Jug, Xin Liu, Endi Wang
Classical Hodgkin lymphoma (cHL) typically involves lymph node parenchyma, and a case with Hodgkin cells confined within nodal sinusoids is extremely rare. Herein we report a case of cHL with a sinusoidal growth pattern. This 15-year old patient presented with B symptoms and was found to have bilateral cervical lymphadenopathy and an anterior mediastinal mass. Biopsy of a cervical lymph node demonstrated cohesive clusters of Reed-Sternberg (RS)-like cells suggestive of sinusoidal growth with an extrasinusoidal mixed inflammatory cell infiltrate characteristic of the microenvironment seen in cHL...
June 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28545570/the-feasibility-of-contrast-enhanced-ultrasonography-ceus-in-the-diagnosis-of-non-cardiac-thoracic-disorders-of-dogs-and-cats
#16
N Linta, M Baron Toaldo, G Bettini, A Cordella, M Quinci, P Pey, V Galli, M Cipone, A Diana
BACKGROUND: This study describes the feasibility of Contrast Enhanced Ultrasonography (CEUS) in the diagnostic work-up of non-cardiac thoracic disorders of small animals. The second aim is to assess the usefulness of CEUS as a direct guide for sample procedures. RESULTS: Forty animals, 28 dogs and 12 cats, were included in the study. Thoracic disorders included 23 pulmonary lesions [primary carcinoma (14), lymphoma (1), sarcoma (1), histiocytic sarcoma (1), abscess (1) and pneumonia (5)] and 17 mediastinal lesions [lymphoma (8), thymoma (3), mesothelioma (1), melanoma (1), carcinomatous lymphadenopathy (1), mixsosarcoma (1), lipoma (1), and abscess (1)]...
May 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28532447/clinical-characteristics-of-disseminated-cryptococcosis-in-previously-healthy-children-in-china
#17
Li-Wei Gao, An-Xia Jiao, Xi-Rong Wu, Shun-Ying Zhao, Yun Ma, Gang Liu, Ju Yin, Bao-Ping Xu, Kun-Ling Shen
BACKGROUND: Disseminated cryptococcosis is a rare and fatal disease, and limited data exist regarding it in children. This study aimed to investigate the clinical characteristics of disseminated cryptococcosis in previously healthy children in China. METHODS: Hospitalized patients with disseminated cryptococcosis were enrolled during January 1996 to December 2015 in Beijing Children's Hospital, Capital Medical University, China. Data on clinical manifestations, laboratory tests, treatment, and prognosis were evaluated...
May 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28528060/pulmonary-mucormycosis-treated-with-lobectomy
#18
Oluwatobi Afolayan, Hannah Copeland, Salman Zaheer, Jason M Wallen
A 57 year old man was referred from an outside facility for an unresolving pneumonia. Imaging of the chest demonstrated a right lung mass with a consolidation in the middle lobe, pleural effusion, and mediastinal lymphadenopathy. Cytologic examination of cultures from the bronchoscopy and thoracentesis did not yield a definitive diagnosis. Video-assisted thoracoscopic surgery (VATS) was performed because of a retained hemothorax and a suggestive lesion. Biopsy specimens obtained during VATS were consistent with mucormycosis...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28525608/surgical-resection-for-advanced-lung-cancer-using-the-hemi-clamshell-approach
#19
Yasushi Shintani, Ryu Kanzaki, Tomohiro Kawamura, Soichiro Funaki, Masato Minami, Meinoshin Okumura, Eiji Okura, Yoshihisa Kadota, Mitsunori Ohta
OBJECTIVES: The hemi-clamshell (HCS) approach consists of partial sternotomy with antero-lateral thoracotomy. This study evaluated the utilities and outcomes of the HCS approach in advanced lung cancer patients. METHODS: We retrospectively investigated 45 patients who underwent surgery for advanced lung cancer via the HCS procedure between 2000 and 2014, the indications for surgery being tumour invasion extending to the aorta arch in 5, descending aorta in 9, main pulmonary artery in 5, superior vena cava in 6, right or left atrium in 4, apical thoracic dome in 7 patients and mediastinal lymphadenopathy for left-sided lung cancer in 12...
May 19, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28511175/flexible-19-gauge-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-needle-first-experience
#20
Chung Tyan, Priya Patel, Kasia Czarnecka, Daniela Gompelmann, Ralf Eberhardt, Marc Fortin, Paul MacEachern, Christopher A Hergott, Elaine Dumoulin, Alain Tremblay, Samuel V Kemp, Pallav L Shah, Felix J F Herth, Kazuhiro Yasufuku
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established first-line invasive modality for mediastinal lymph node staging in lung cancer patients and in the diagnostic workup of patients with mediastinal adenopathy. With the current 21- and 22-gauge (G) EBUS-TBNA needles, the procedure can be limited by the degree of flexibility in the needle and the size of the lumen in tissue acquisition. OBJECTIVE: We report our initial experience with a first-generation flexible 19-G EBUS-TBNA (Flex 19G; Olympus Respiratory America, Redmond, WA, USA) needle with regards to efficacy and safety...
2017: Respiration; International Review of Thoracic Diseases
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