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https://www.readbyqxmd.com/read/29684316/continuous-positive-airway-pressure-adherence-predictors-in-a-randomized-controlled-trial-enriched-with-women-and-minorities
#1
Anna M May, Tarek Gharibeh, Lu Wang, Amanda Hurley, Harneet Walia, Kingman P Strohl, Reena Mehra
BACKGROUND: Suboptimal continuous positive airway pressure (CPAP) adherence in obstructive sleep apnea (OSA) clinical trials involving predominantly Caucasian males limits interpretability and generalizability. We examined predictors of CPAP adherence in a clinical trial enriched with minorities. METHODS: The Sleep Apnea Stress Study - a randomized double-blind, sham-controlled trial of moderate-severe OSA patients - included participants with complete 8-week adherence data (n=138)...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29683758/asthma-copd-overlap-phenotypes-and-smoking-comparative-features-of-asthma-in-smoking-or-non-smoking-patients-with-an-incomplete-reversibility-of-airway-obstruction
#2
Louis-Philippe Boulet, Marie-Ève Boulay, Jude-Lyne Dérival, Joanne Milot, Johane Lepage, Lara Bilodeau, François Maltais
The development of COPD features, such as an incomplete reversibility of airway obstruction (IRAO), in smoking or non-smoking asthmatic patients, a condition often named Asthma-COPD Overlap (ACO), has been recognized for decades. However, there is a need to know more about the sub-phenotypes of this condition according to smoking. This study aimed at comparing the clinical, physiological and inflammatory features of smoking and non-smoking asthmatic patients exhibiting IRAO. In this cross-sectional study, patients with an IRAO with (ACO, ≥20 pack-years) or without (NS-IRAO, <5 pack-years) significant smoking history completed questionnaires about asthma control (ACQ, score 0-6, 6 = better score) and quality of life (AQLQ, score 1-7, 1 = better score) and performed expiratory flows, lung volume and carbon monoxide diffusion capacity measurements...
April 23, 2018: COPD
https://www.readbyqxmd.com/read/29683730/biologic-drugs-a-new-target-therapy-in-copd
#3
Ahmed Yousuf, Christopher E Brightling
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease associated with significant morbidity and mortality. Current diagnostic criteria based on the presence of fixed airflow obstruction and symptoms do not integrate the complex pathological changes occurring within the lung and they do not define different airway inflammatory patterns. The current management of COPD is based on 'one size fits all' approach and does not take the importance of heterogeneity in COPD population into account. The available treatments aim to alleviate symptoms and reduce exacerbation frequency but do not alter the course of the disease...
April 23, 2018: COPD
https://www.readbyqxmd.com/read/29682699/effects-of-continuous-positive-airway-pressure-on-cardiovascular-biomarkers-in-patients-with-obstructive-sleep-apnea-a-meta-analysis-of-randomized-controlled-trials
#4
Yu Ning, Tian-Song Zhang, Wan-Wan Wen, Kun Li, Yun-Xiao Yang, Yan-Wen Qin, Hui-Na Zhang, Yun-Hui Du, Lin-Yi Li, Song Yang, Yun-Yun Yang, Miao-Miao Zhu, Xiao-Lu Jiao, Yan Zhang, Ming Zhang, Yong-Xiang Wei
PURPOSE: Obstructive sleep apnea (OSA) is associated with increased levels of systemic inflammatory markers, increased arterial stiffness, and endothelial dysfunction, which may lead to increased cardiovascular risk. We aimed to quantify the effects of continuous positive airway pressure (CPAP) on cardiovascular biomarkers and to establish predictors of response to CPAP. METHODS: We searched PubMed and the Cochrane Library from inception to May 31, 2017. Randomized controlled trials (RCTs) assessing the efficacy of CPAP on high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor- alpha (TNF-α), augmentation index (AIx), pulse wave velocity (PWV), and flow-mediated dilatation (FMD) in patients with OSA were selected by consensus...
April 22, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29682479/submandibular-lipoblastoma-case-report-of-a-rare-tumor-in-childhood
#5
Olfa El Amine, Meyssa Belghith, Hasna Salhi, Aida Goucha, Amor Gamoudi
Lipoblastoma is a rare, benign tumor usually occurring in childhood. It is essentially localized in the extremities and trunk, with few cases reported in the neck. We report the case of a 2-year-old girl with a rapidly enlarging, painless neck mass. Magnetic resonance imaging (MRI) revealed a 3-cm mass in the right submandibular region. Review of literature, diagnostic methods, and genetics of lipomatous tumors are discussed. Complete surgical excision via a lateral cervical approach demonstrated a white soft tissue with an adherent ganglion...
April 2018: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29682268/polysonographical-evaluation-in-a-case-of-moderate-osas-treated-with-mandibular-advancement-device
#6
A Venditti, M Basili, F M Ragazzoni, A Barlattani, P Bollero
Background: The Obstructive Sleep Apnea Syndrome (OSAS) is a clinical picture characterized by partial or complete obstruction of the upper airway during sleep, associated with a reduction of oxygen saturation in the blood.The most common symptoms are: apnea sleep, snoring, headache, sleepiness, reduced concentration and memory, irritability, increased blood pressure and dry mouth. Materials and methods: It was examinated a not-smoker man of 54 years that suffers of roncophaty...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29682267/an-unusual-deceptive-delayed-of-profuse-haemorrhage-after-mandibular-implant-dentistry-risk-planning-and-medico-legal-instruction
#7
R M Gaudio, E El Haddad, G El Haddad, D Lauritano, F Carinci
Mandibular implant placement (MIP) has been accepted and widely used for decades all over the world, and has reached a very high level of therapeutic reliability. MIP is used mostly in elderly edentulous patients who lost their teeth when dentistry was not oriented to fixed or removable prosthetic. Notwithstanding this, every year cases of severe complications during MIP due to haemorrhage causing life-threatening airway's obstruction are reported. These severe complications of MIP need immediate therapy, usually with hospitalization, and may be potentially fatal...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29680435/comparison-of-two-exhaled-biomarkers-in-children-with-and-without-sleep-disordered-breathing
#8
Mario Barreto, Paolo Montuschi, Melania Evangelisti, Susanna Bonafoni, Manuela Cecili, Rugia Shohreh, Giuseppe Santini, Maria Pia Villa
OBJECTIVE: Airway oxidative stress and inflammation are likely to be involved in sleep disordered breathing (SDB) in children. We aimed to measure concentrations of 8-isoprostane (8-IsoP) in the exhaled breath condensate (EBC) and exhaled nitric oxide (FENO ) in patients with SBD and healthy children, in order to assess the relationship between these two biomarkers, disease severity, and overnight changes. METHODS: Patients with SDB (n = 46) and healthy controls (n = 20) aged 4...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680418/uvulopalatopharyngoplasty-reduces-the-incidence-of-cardiovascular-complications-caused-by-obstructive-sleep-apnea-results-from-the-national-insurance-service-survey-2007-2014
#9
Heung Man Lee, Hyo Yeol Kim, Jeffrey D Suh, Kyung-Do Han, Jin Kook Kim, Young Chang Lim, Seok-Chan Hong, Jae Hoon Cho
OBJECTIVE: Untreated obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease including myocardial infarction (MI), congestive heart failure (CHF), and atrial fibrillation (AF). Continuous positive airway pressure (CPAP) is an effective treatment for OSA; however, compliance with CPAP can be challenging for some patients. The objective of this study was to investigate whether uvulopalatopharyngoplasty (UPPP) reduced the risk of cardiovascular complications for patients with OSA...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680416/electrocardiographic-variables-in-children-with-syndromic-craniosynostosis-and-primary-snoring-to-mild-obstructive-sleep-apnea-significance-of-identifying-respiratory-arrhythmia-during-sleep
#10
Ellaha Kakar, Linda J A Corel, Robert C Tasker, Robbin de Goederen, Eppo B Wolvius, Irene M J Mathijssen, Koen F M Joosten
BACKGROUND: In the spectrum of children with symptomatic sleep disordered breathing (SDB), some individuals - such as those with upper airway resistance syndrome (UARS) - do not have abnormalities on polysomnography (PSG). In this study we have assessed whether assessment of respiratory arrhythmia (RA) and heart rate variability (HRV) analysis helps in management of children with syndromic craniosynostosis and none-to-mild obstructive sleep apnea (OSA). METHODS: Prospective cohort study in children aged 1-18 years old with syndromic craniosynostosis...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29678782/early-feasibility-of-hypoglossal-nerve-upper-airway-stimulator-in-patients-with-cardiac-implantable-electronic-devices-and-continuous-positive-airway-pressure-intolerant-severe-obstructive-sleep-apnea
#11
Valay Parikh, Erica Thaler, Masanari Kato, M Boyd Gillespie, Shaun Nguyen, Kirk Withrow, David Calhoun, Ryan Soose, Damien Stevens, Suzanne Stevens, Chris Larsen, Madhu Reddy, Dhanunjaya Lakkireddy
BACKGROUND: Implantable hypoglossal nerve upper airway stimulation (HNS) is a novel, FDA approved strategy for management of moderate to severe obstructive sleep apnea(OSA) patients with continuous positive airway pressure (CPAP) therapy intolerance or failure. Due to proximity of Cardiac Implantable Electronic Devices (CIED) and this stimulator, interaction between these devices is theoretically possible. OBJECTIVE: The purpose of this study was to assess interactions between implantable hypoglossal nerve upper airway stimulator device and cardiac implantable electronic devices...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29678351/clinical-and-inflammatory-phenotyping-can-electronic-nose-and-nmr-based-metabolomics-work-at-the-bedside
#12
Mauro Maniscalco, Andrea Motta
Electronic nose (eNose) and nuclear magnetic resonance (NMR)-based metabolomics seem to be able to identify metabolic and inflammatory profiles in patients with chronic obstructive diseases. The hypothesis arises from three recent studies using two different methods in patients with asthma and chronic obstructive pulmonary diseases (COPD), opening promising diagnostic perspectives. The possibility that the use of eNose and NMR-based metabolomics might provide clinical/inflammatory characteristics is intriguing...
April 17, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29678147/protocol-based-evaluation-for-feasibility-of-extubation-compared-to-clinical-scoring-systems-after-major-oral-cancer-surgery-safely-reduces-the-need-for-tracheostomy-a-retrospective-cohort-study
#13
Axel Schmutz, Rolf Dieterich, Johannes Kalbhenn, Pit Voss, Torsten Loop, Sebastian Heinrich
BACKGROUND: Despite risks, complications and negative impact to quality of life, tracheostomy is widely used to bypass upper airway obstruction after major oral cancer surgery (MOCS). Decision to tracheostomy is frequently based on clinical scoring systems which mainly have not been validated by different cohorts. Delayed extubation in the Intensive Care Unit (ICU) may be a suitable alternative in selected cases. We hypothesize that delayed routine ICU extubation after MOCS instead of scoring system based tracheostomy is safe, feasible and leads to lower tracheostomy rates...
April 20, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29676929/the-role-of-upper-airway-morphology-in-apnea-versus-hypopnea-predominant-obstructive-sleep-apnea-patients-an-exploratory-study
#14
Tülay Özer, Adin Selcuk, Zahide Yılmaz, Nuray Voyvoda, İsa Çam, İsa Çam, Halil Erdem Ozel, Fatih Özdogan, Erkan Esen, Gülden Genç, Gulden Genc, Selahattin Genc
OBJECTIVES: The objective of this study was to investigate the association between upper airway morphology and apnea versus hypopnea predominance in patients with obstructive sleep apnea syndrome. METHODS: A retrospective study on consecutively computerized tomography scans obtained from 54 obstructive sleep apnea patients and 53 non-snoring controls. Computerized tomography scans were measured to evaluate upper airway and surrounding structures' morphologic characteristics...
April 20, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29676620/interleukin-13-stimulation-reveals-the-cellular-and-functional-plasticity-of-the-airway-epithelium
#15
Max A Seibold
About 50% of patients with asthma exhibit chronic airway inflammation driven by the type 2 cytokines interleukin (IL)-4, IL-5, and IL-13. These patients with type 2-high asthma experience more allergic symptoms, greater airway hyperresponsiveness, and more severe mucus obstruction than patients with type 2-low asthma. Mouse models of asthma have shown that much of the airway dysfunction in these models can be generated by IL-13 stimulation of the airway epithelium alone. Both in vivo mouse model studies and in vitro studies of human mucociliary airway epithelial cultures have shown that IL-13 induces cellular remodeling of the airway epithelium through proliferation-independent transdifferentiation processes...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676069/perceptions-of-severe-asthma-and-asthma-copd-overlap-syndrome-among-specialists-a-questionnaire-survey
#16
Sang Heon Kim, Ji Yong Moon, Jae Hyun Lee, Ga Young Ban, Sujeong Kim, Mi Ae Kim, Joo Hee Kim, Min Hye Kim, Chan Sun Park, So Young Park, Hyouk Soo Kwon, Jae Woo Kwon, Jae Woo Jung, Hye Ryun Kang, Jong Sook Park, Tae Bum Kim, Heung Woo Park, You Sook Cho, Kwang Ha Yoo, Yeon Mok Oh, Byung Jae Lee, An Soo Jang, Sang Heon Cho, Hae Sim Park, Choon Sik Park, Ho Joo Yoon
PURPOSE: Severe asthma and asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) are difficult to control and are often associated with poor clinical outcomes. However, much is not understood regarding the diagnosis and treatment of severe asthma and ACOS. To evaluate the current perceptions of severe asthma and COPD among asthma and COPD specialists, we designed an e-mail and internet-based questionnaire survey. METHODS: Subjects were selected based on clinical specialty from among the members of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Academy of Tuberculosis and Respiratory Diseases...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675059/natural-history-of-treatment-emergent-central-sleep-apnea-on-positive-airway-pressure-a-systematic-review
#17
Gaurav Nigam, Muhammad Riaz, Edward T Chang, Macario Camacho
INTRODUCTION: Treatment-emergent central sleep apnea (TECSA) is observed in some patients when they are treated with positive airway pressure (PAP) after significant resolution of the preexisting obstructive events in patients with obstructive sleep apnea. The objective of this study was to systematically review the literature for studies describing the natural history of TECSA. METHODS: PubMed, Medline, Scopus, Web of Science, and Cochran Library databases were searched through June 29, 2017...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29674392/cholesterol-metabolism-promotes-b-cell-positioning-during-immune-pathogenesis-of-chronic-obstructive-pulmonary-disease
#18
Jie Jia, Thomas M Conlon, Rim Sj Sarker, Demet Taşdemir, Natalia F Smirnova, Barkha Srivastava, Stijn E Verleden, Gizem Güneş, Xiao Wu, Cornelia Prehn, Jiaqi Gao, Katharina Heinzelmann, Jutta Lintelmann, Martin Irmler, Stefan Pfeiffer, Michael Schloter, Ralf Zimmermann, Martin Hrabé de Angelis, Johannes Beckers, Jerzy Adamski, Hasan Bayram, Oliver Eickelberg, Ali Önder Yildirim
The development of chronic obstructive pulmonary disease (COPD) pathogenesis remains unclear, but emerging evidence supports a crucial role for inducible bronchus-associated lymphoid tissue (iBALT) in disease progression. Mechanisms underlying iBALT generation, particularly during chronic CS exposure, remain to be defined. Oxysterol metabolism of cholesterol is crucial to immune cell localization in secondary lymphoid tissue. Here, we demonstrate that oxysterols also critically regulate iBALT generation and the immune pathogenesis of COPD In both COPD patients and cigarette smoke (CS)-exposed mice, we identified significantly upregulated CH25H and CYP7B1 expression in airway epithelial cells, regulating CS-induced B-cell migration and iBALT formation...
April 19, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29672230/diaphragm-plasticity-in-aging-and-disease-therapies-for-muscle-weakness-go-from-strength-to-strength
#19
Sarah M Greising, Coen A C Ottenheijm, Ken D O'Halloran, Esther Barreiro
The diaphragm is the main inspiratory muscle and is required to be highly active throughout the lifespan. The diaphragm muscle must be able to produce and sustain various behaviors that range from ventilatory to non-ventilatory such as those required for airway maintenance and clearance. Throughout the lifespan various circumstances and conditions may affect the ability of the diaphragm muscle to generate requisite forces and in turn the diaphragm muscle may undergo significant weakness and dysfunction. For example, hypoxic stress, critical illness, cancer cachexia, chronic obstructive pulmonary disorder (COPD), and age-related sarcopenia all represent conditions in which significant diaphragm muscle dysfunction exits...
April 19, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29672227/mimicking-a-flow-limited-human-upper-airway-using-a-collapsible-tube-relationships-between-flow-patterns-and-pressures-in-a-respiratory-model
#20
Kaixian Zhu, Ramon Farre, Ira Katz, Sébastien Hardy, Pierre Escourrou
The upper airway (UA) in humans is commonly modeled as a Starling resistor. However, negative effort dependence (NED) observed in some patients with obstructive sleep apnea (OSA) contradicts predictions based on the Starling resistor model in which inspiratory flow is independent of inspiratory driving pressure when flow is limited. In a respiratory bench model consisting of a collapsible tube and an active lung model (ASL5000), inspiratory flow characteristics were investigated in relation to upstream, downstream and extra-luminal pressures (denoted as Pus, Pds and Pout, respectively) by varying inspiratory effort (muscle pressure) from -1 to -20 cmH2 O in the active lung...
April 19, 2018: Journal of Applied Physiology
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