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JOURNAL ARTICLE
Yuan Zhi, Mehdi Madanchi, Giacomo Maria Cioffi, Julian Brunner, Leah Stutz, Eleonora Gnan, Varis Gjergjizi, Adrian Attinger-Toller, Florim Cuculi, Matthias Bossard
BACKGROUND: Patients with acute myocardial infarction (AMI) and large thrombus burden (LTB) still represent a challenge. Afflicted patients have a high morbidity and mortality. Aspiration thrombectomy is often ineffective in those cases. Mechanical thrombectomy devices (MTDs), which are effective for management of ischemic strokes, were recently CE-approved for treatment of thrombotic coronary lesions. Real-world data about their performance in AMI cases with LTB are scarce. This study sought to summarize our early experience with a novel MTD device in this context...
April 20, 2024: Cardiovascular Intervention and Therapeutics
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JOURNAL ARTICLE
Emanuela Andretta, Stefania De Chiara, Chiara Pagliuca, Roberta Cirella, Elena Scaglione, Martina Di Rosario, Maxim S Kokoulin, Olga I Nedashkovskaya, Alba Silipo, Paola Salvatore, Antonio Molinaro, Flaviana Di Lorenzo
Gram-negative bacteria living in marine waters have evolved peculiar adaptation strategies to deal with the numerous stress conditions that characterize aquatic environments. Among the multiple mechanisms for efficient adaptation, these bacteria typically exhibit chemical modifications in the structure of the lipopolysaccharide (LPS), which is a fundamental component of their outer membrane. In particular, the glycolipid anchor to the membrane of marine bacteria LPSs, i.e. the lipid A, frequently shows unusual chemical structures, which are reflected in equally singular immunological properties with potential applications as immune adjuvants or anti-sepsis drugs...
April 20, 2024: Glycoconjugate Journal
#23
JOURNAL ARTICLE
Moustapha Touré, Sarah-Maria Sfairy, Suzanne K Bédard, Nathalie McFadden, Robert Hanel, Frédéric Lemay, Jie He, Michel Pavic, Thomas G Poder
BACKGROUND: Because health resources are limited, health programs should be compared to allow the most efficient ones to emerge. To that aim, health utility instruments have been developed to allow the calculation of quality-adjusted life-year (QALY). However, generic instruments, which can be used by any individual regardless of their health profile, typically consider the preferences of the general population when developing their value set. Consequently, they are often criticized for lacking sensitivity in certain domains, such as cancer...
April 20, 2024: Quality of Life Research
#24
JOURNAL ARTICLE
Mingyue Du, Xiyuan Gao, Ling Chen
Doubly censored failure time data occur in many areas and for the situation, the failure time of interest usually represents the elapsed time between two related events such as an infection and the resulting disease onset. Although many methods have been proposed for regression analysis of such data, most of them are conditional on the occurrence time of the initial event and ignore the relationship between the two events or the ancillary information contained in the initial event. Corresponding to this, a new sieve maximum likelihood approach is proposed that makes use of the ancillary information, and in the method, the logistic model and Cox proportional hazards model are employed to model the initial event and the failure time of interest, respectively...
April 20, 2024: Lifetime Data Analysis
#25
JOURNAL ARTICLE
Tamara Teodoro Araujo, Aline Dionizio, Thamyris Souza Carvalho, Chelsea Maria Vilas Boas Feitosa, Mariele Vertuan, João Victor Frazão Câmara, Flavio Henrique-Silva, Reinaldo Marchetto, Marcos Roberto Chiaratti, Angélica Camargo Santos, Lindomar Oliveira Alves, Milene Ferro, Marília Afonso Rabelo Buzalaf
OBJECTIVE: This study was designed in two-legs. In the in vivo, we explored the potential of a rinse solution containing a combination (Comb) of 0.1 mg/mL CaneCPI-5 (sugarcane-derive cystatin), 1.88 × 10- 5 M StN15 (statherin-derived peptide) and 1.0 mg/mL hemoglobin (Hb) to change the protein profile of the acquired enamel pellicle(AEP) and the microbiome of the enamel biofilm. The in vitro, was designed to reveal the effects of Comb on the viability and bacterial composition of the microcosm biofilm, as well as on enamel demineralization...
April 20, 2024: Clinical Oral Investigations
#26
JOURNAL ARTICLE
Yizeng Fang, Luwen Lu, Kang Chen, Xiurong Wang
BACKGROUND AND AIMS: Plants have adapted to acquire phosphorus (P) primarily through advantageous root morphologies, responsive physiological pathways, and associations with mycorrhizal fungi. Yet, to date, little information exists on how variation in arbuscular mycorrhizal (AM) colonization is coordinated with root morphological and physiological traits to enhance P acquisition. METHODS: Thirteen root functional traits associated with P acquisition were characterized at full bloom stage in pot cultures under low soil P availability conditions for 13 soybean genotypes contrasting in AM colonization...
April 20, 2024: Annals of Botany
#27
JOURNAL ARTICLE
Marius Pascaud, Frederic Thevenet, Caroline Duc, Cedric Samuel, Nathalie Redon, Manolis N Romanias
Polyaniline (PAni)-based sensors are a promising solution for ammonia (NH3 ) detection at the ppb level. However, the nature of the NH3 -PAni interaction and underlying drivers remain unclear. This paper proposes to characterize the interaction between doped PAni (dPAni) sensing material and NH3 by using a Knudsen cell. First, to characterize the dPAni interface, the probe-gas method, i.e., titration of surface sites with a gas of specific properties, is deployed. The dPAni interface is found to be homogeneous with more than 96% of surface sites of acid nature or with hydroxyl functional groups...
April 20, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
#28
JOURNAL ARTICLE
Zhiyu Shi, Aditya Dilip Lele, Ahren W Jasper, Stephen J Klippenstein, Yiguang Ju
Machine learning (ML) provides a great opportunity for the construction of models with improved accuracy in classical molecular dynamics (MD). However, the accuracy of a ML trained model is limited by the quality and quantity of the training data. Generating large sets of accurate ab initio training data can require significant computational resources. Furthermore, inconsistent or incompatible data with different accuracies obtained using different methods may lead to biased or unreliable ML models that do not accurately represent the underlying physics...
April 20, 2024: Journal of Physical Chemistry. A
#29
JOURNAL ARTICLE
Gerald J Kost, Jenna Dohner, Janet Liu, Dean Ramos, Nabiya Haider, Varsha Thalladi
OBJECTIVES: To survey the World Wide Web for critical limits/critical values, assess changes in quantitative low/high thresholds since 1990-93, streamline urgent notification practices, and promote global accessibility. METHODS: We identified Web-posted lists of critical limits/values at university hospitals. We compared 2023 to 1990-93 archived notification thresholds. RESULTS: We found critical notification lists for 26 university hospitals...
April 22, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
#30
JOURNAL ARTICLE
Chantat Leong, Zhiying Zhao, Zhen Yuan, Bin Liu
SIGNIFICANT: Chunk memory is one of the essential cognitive functions for high-expertise (HE) player to make efficient decisions. However, it remains unknown how the neural mechanisms of chunk memory processes mediate or alter chess players' performance when facing different opponents. AIM: This study aimed at inspecting the significant brain networks associated with chunk memory, which would vary between club players and novices. APPROACH: Functional networks and topological features of 20 club players (HE) and 20 novice players (LE) were compared at different levels of difficulty by means of functional near-infrared spectroscopy...
April 2024: Brain and Behavior
#31
JOURNAL ARTICLE
Elliot Silver, Jeffry Nahmias, Michael Lekawa, Kenji Inaba, Morgan Schellenberg, Christian De Virgilio, Areg Grigorian
Objective: Many current trauma mortality prediction tools are either too intricate or rely on data not readily available during a trauma patient's initial evaluation. Moreover, none are tailored to those necessitating urgent or emergent surgery. Our objective was to design a practical, user-friendly scoring tool using immediately available variables, and then compare its efficacy to the widely-known Revised Trauma Score (RTS). Methods: The adult 2017-2021 Trauma Quality Improvement Program (TQIP) database was queried to identify patients ≥18 years old undergoing any urgent/emergent operation (direct from Emergency Department to operating room)...
April 19, 2024: American Surgeon
#32
JOURNAL ARTICLE
Ezequiel Fernandez-Tschieder, John D Marshall, Dan Binkley
Large trees in plantations generally produce more wood per unit of resource use than small trees. Two processes may account for this pattern: greater photosynthetic resource use efficiency or greater partitioning of carbon to wood production. We estimated gross primary production (GPP) at the individual scale by combining transpiration with photosynthetic water-use efficiency of Eucalyptus trees. Aboveground production fluxes were estimated using allometric equations and modeled respiration; total belowground carbon fluxes (TBCF) were estimated by subtracting aboveground fluxes from GPP...
April 19, 2024: New Phytologist
#33
JOURNAL ARTICLE
Aklilu Endalamaw, Resham B Khatri, Tesfaye Setegn Mengistu, Daniel Erku, Eskinder Wolka, Anteneh Zewdie, Yibeltal Assefa
BACKGROUND: The growing adoption of continuous quality improvement (CQI) initiatives in healthcare has generated a surge in research interest to gain a deeper understanding of CQI. However, comprehensive evidence regarding the diverse facets of CQI in healthcare has been limited. Our review sought to comprehensively grasp the conceptualization and principles of CQI, explore existing models and tools, analyze barriers and facilitators, and investigate its overall impacts. METHODS: This qualitative scoping review was conducted using Arksey and O'Malley's methodological framework...
April 19, 2024: BMC Health Services Research
#34
JOURNAL ARTICLE
Yang Hu, Ming-Cheng Du, Guo-Hong Zhu, Xiang Long, Jing-Jing Jiang, Yuan Gong
BACKGROUND: Opioids such as sufentanil are used as anaesthetics due to their rapid action and superior analgesic effect. However, sufentanil induces a huge cough in paediatric patients. In contrast, intravenous (IV) lidocaine suppresses opioid-induced cough in children, but its use is limited due to anaesthetists' concern about its toxicity. Therefore, this study aimed to evaluate the effect of dose-dependent IV lidocaine on sufentanil-induced cough (SIC) in paediatric patients. METHODS: A total of 188 patients aged 3-12 years scheduled for elective tonsillectomy with or without adenoidectomy were enrolled and divided into four groups depending on different dose of lidocaine: A (0 mg...
April 19, 2024: BMC Anesthesiology
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JOURNAL ARTICLE
DaeYong Lee, Kristin Huntoon, Yifan Wang, Minjeong Kang, Yifei Lu, Seong Dong Jeong, Todd M Link, Thomas D Gallup, Yaqing Qie, Xuefeng Li, Shiyan Dong, Benjamin R Schrank, Adam J Grippin, Abin Antony, JongHoon Ha, Mengyu Chang, Yi An, Liang Wang, Dadi Jiang, Jing Li, Albert C Koong, John A Tainer, Wen Jiang, Betty Y S Kim
Intracellular DNA sensors regulate innate immunity and can provide a bridge to adaptive immunogenicity. However, the activation of the sensors in antigen-presenting cells (APCs) by natural agonists such as double-stranded DNAs or cyclic nucleotides is impeded by poor intracellular delivery, serum stability, enzymatic degradation and rapid systemic clearance. Here we show that the hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate innate immune pathways via endoplasmic reticulum stress in APCs...
April 19, 2024: Nature Biomedical Engineering
#36
JOURNAL ARTICLE
Yomna F Hassan, Dalia A Shabaan
Chemotherapy-induced alopecia (CIA) represents one of the most severe side effects of chemotherapy, which forces some patients to reject cancer treatment. The exact pathophysiological mechanisms of CIA are not clearly understood, which makes it difficult to discover efficient preventive or therapeutic procedures for this adverse effect. N-acetylcysteine (NAC) has a strong antioxidant activity as it stimulates glutathione synthesis and acts as an oxygen radical scavenger. The current study tried to investigate the efficacy of NAC in preserving biochemical parameters and hair follicle structure against cyclophosphamide (CYP) administration...
April 20, 2024: Histochemistry and Cell Biology
#37
JOURNAL ARTICLE
Gabriela Manco Machado, Ana Clara Falabello Luca, Renata Paz Leal Pereira, Ana Yne Fernandez, Lucas Gabriel Santini Rodrigues, Isabella Petroline Leite, Maximiliano Sergio Cenci, Tatiana Pereira Cenci, Ana Paula Pires Santos, Branca Heloisa Oliveira, Paulo Nadanovsky, Marina Deus Moura Lima, Marcoeli Silva Moura, Edson Hilan Gomes Lucena, Tathiane Larissa Lenzi, Ana Carla Crispim, Fernanda Campos Almeida Carrer, Mariana Gabriel, Claudia Cazal Lira, Carla Vecchione Gurgel, Helder Henrique Costa Pinheiro, Gilberto Alfredo Pucca, Fábio Carneiro Martins, Paola Gondim Calvasina, Maria Fernanda Montezuma Tricoli, Camila Menezes Costa Castelo Branco, Raiza Dias Freitas, José Carlos Pettorossi Imparato, Daniela Prócida Raggio, Tamara Kerber Tedesco, Fausto Medeiros Mendes, Mariana Minatel Braga
BACKGROUND: Important evidence has been constantly produced and needs to be converted into practice. Professional consumption of such evidence may be a barrier to its implementation. Then, effective implementation of evidence-based interventions in clinical practice leans on the understanding of how professionals value attributes when choosing between options for dental care, permitting to guide this implementation process by maximizing strengthens and minimizing barriers related to that...
April 19, 2024: BMC Oral Health
#38
JOURNAL ARTICLE
Xiwei She, Kerry C Nix, Christopher C Cline, Wendy Qi, Sergei Tugin, Zihuai He, Fiona M Baumer
Transcranial magnetic stimulation paired with electroencephalography (TMS-EEG) can measure local excitability and functional connectivity. To address trial-to-trial variability, responses to multiple TMS pulses are recorded to obtain an average TMS evoked potential (TEP). Balancing adequate data acquisition to establish stable TEPs with feasible experimental duration is critical when applying TMS-EEG to clinical populations. Here we aim to investigate the minimum number of pulses (MNP) required to achieve stable TEPs in children with epilepsy...
April 20, 2024: Scientific Reports
#39
JOURNAL ARTICLE
Qin Yalan, Hao Lingfang, Liu Xisong, Liang Run, Zhang Junjing, Zhang' An
BACKGROUND: Monoclonal antibody therapy for Covid-19 springs up all over the world and get some efficiency. This research aims to explore the treating effect of BRII-196(Ambavirumab) plus BRII-198(Lomisivir) on Covid-19. METHODS: In this retrospective cohort research, patients received standard care or plus BRII-196 /BRII-198 monoclonal antibodies. General comparison of clinical indexes and prognosis between Antibody Group and Control Group was made. Further, according to the antibody using time and patients' condition, subgroups included Early antibody group, Late antibody group, Mild Antibody Group, Mild Control Group, Severe Antibody Group and Severe Control Group...
April 19, 2024: BMC Pharmacology & Toxicology
#40
JOURNAL ARTICLE
Hansheng Wang, Jiankun Wang, Yan Liu, Yunyun Wang, Yanhui Zhou, Dan Yu, Hui You, Tao Ren, Yijun Tang, Meifang Wang
BACKGROUND AND OBJECTIVE: EBUS-TBNA has emerged as an important minimally invasive procedure for the diagnosis and staging of lung cancer. Our objective was to evaluate the effect of different specimen preparation from aspirates on the diagnosis of lung cancer. METHODS: 181 consecutive patients with known or suspected lung cancer accompanied by hilar / mediastinal lymphadenopathy underwent EBUS-TBNA from January 2019 to December 2022. Specimens obtained by EBUS-TBNA were processed by three methods: Traditional smear cytology of aspirates (TSC), liquid-based cytology of aspirates (LBC) and histopathology of core biopsies...
April 19, 2024: Diagnostic Pathology
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