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https://www.readbyqxmd.com/read/29332354/inhibition-of-telomerase-potentiates-enzalutamide-efficiency-of-androgen-sensitive-human-prostate-cancer-cells
#1
Karaca Kaan Gecgel, Mustafa Muduroglu, Suat Erdogan
PURPOSE: Androgen deprivation therapy (ADT) is one of the main strategies to treat prostate cancer (PCa) at various stages of its development. Androgen receptor (AR) antagonists such as enzalutamide are mainstay treatments for castration-sensitive prostate cancer. Though, a majority of patients initially respond to ADT, most will eventually progress to castrate-resistant, due to the development of different mutations on the AR. PCa cells express high telomerase activity, and there is a correlation between the total activity of telomerase and the Gleason score...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332214/targeted-next-generation-sequencing-in-patients-with-non-syndromic-congenital-heart-disease
#2
Silvia Pulignani, Cecilia Vecoli, Andrea Borghini, Ilenia Foffa, Lamia Ait-Alì, Maria Grazia Andreassi
Congenital heart disease (CHD) is a genetically heterogeneous disease. Targeted next-generation sequencing (NGS) offers a unique opportunity to sequence multiple genes at lower cost and effort compared to Sanger sequencing. We tested a targeted NGS of a specific gene panel in a relatively large population of non-syndromic CHD patients. The patient cohort comprised 68 CHD patients (45 males; 8.3 ± 1.7 years). Amplicon libraries for 16 CHD-strictly related genes were generated using a TruSeq® Custom Amplicon kit (Illumina, CA) and sequenced using the Illumina MiSeq platform...
January 13, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29332189/the-arabidopsis-histone-chaperone-fact-is-required-for-stress-induced-expression-of-anthocyanin-biosynthetic-genes
#3
Alexander Pfab, Matthias Breindl, Klaus D Grasser
The histone chaperone FACT is involved in the expression of genes encoding anthocyanin biosynthetic enzymes also upon induction by moderate high-light and therefore contributes to the stress-induced plant pigmentation. The histone chaperone FACT consists of the SSRP1 and SPT16 proteins and associates with transcribing RNAPII (RNAPII) along the transcribed region of genes. FACT can promote transcriptional elongation by destabilising nucleosomes in the path of RNA polymerase II, thereby facilitating efficient transcription of chromatin templates...
January 13, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29331939/volumetric-muscle-loss-injury-repair-using-in-situ-fibrin-gel-cast-seeded-with-muscle-derived-stem-cells-mdscs
#4
Nadine Matthias, Samuel D Hunt, Jianbo Wu, Jonathan Lo, Laura A Smith Callahan, Yong Li, Johnny Huard, Radbod Darabi
Volumetric muscle defect, caused by trauma or combat injuries, is a major health concern leading to severe morbidity. It is characterized by partial or full thickness loss of muscle and its bio-scaffold, resulting in extensive fibrosis and scar formation. Therefore, the ideal therapeutic option is to use stem cells combined with bio-scaffolds to restore muscle. For this purpose, muscle-derived stem cells (MDSCs) are a great candidate due to their unique multi-lineage differentiation potential. In this study, we evaluated the regeneration potential of MDSCs for muscle loss repair using a novel in situ fibrin gel casting...
January 9, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29331806/unifying-in%C3%A2-vitro-and-in%C3%A2-vivo-ivt-mrna-expression-discrepancies-in-skeletal-muscle-via-mechanotransduction
#5
Sushma M Bhosle, Kristin H Loomis, Jonathan L Kirschman, Emmeline L Blanchard, Daryll A Vanover, Chiara Zurla, Damien Habrant, Darin Edwards, Patrick Baumhof, Bruno Pitard, Philip J Santangelo
The translational efficiency of an in vitro transcribed (IVT) mRNA was measured upon delivery to primary skeletal muscle cells and to a mouse model system, towards the development of a predictive in vitro assay for the screening and validation of intramuscular mRNA-based vaccines. When IVT mRNA was delivered either naked or complexed with novel aminoglycoside-based delivery vehicles, significant differences in protein expression in vitro and in vivo were observed. We hypothesized that this previously anticipated discrepancy was due to differences in the mechanism of IVT mRNA endosomal entry and release following delivery...
January 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29331784/degradation-of-dyes-by-peroxymonosulfate-activated-by-ternary-cofeni-layered-double-hydroxide-catalytic-performance-mechanism-and-kinetic-modeling
#6
Hanxuan Zeng, Weiqiu Zhang, Lin Deng, Jinming Luo, Shiqing Zhou, Xia Liu, Yong Pei, Zhou Shi, John Crittenden
Ternary CoFeNi-layered double hydroxide (CoFeNi-LDH) was synthesized and initially applied to activate peroxymonosulfate (PMS) for the degradation of Congo red (CR) and Rhodamine B (RhB). The results show that the CoFeNi-LDH/PMS system can efficiently degrade nearly 100% of 20 mg/L CR or 20 mg/L RhB within 6- and 10-min reaction times, respectively. And the catalyst exhibits higher degradation efficiency on CR than on RhB under identical conditions, which is confirmed by electron clouds of the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) performed by DFT calculations...
January 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29331781/a-step-wise-self-assembly-approach-in-preparation-of-multi-responsive-poly-styrene-co-methyl-methacrylate-nanoparticles-containing-spiropyran
#7
Fahimeh Khakzad, Ali Reza Mahdavian, Hamid Salehi-Mobarakeh, Mohammad Hossain Sharifian
HYPOTHESIS: Surfactant-free emulsion polymerization has become favorable due to circumventing instability issues reasonably. Incorporation of an appropriate hydrophilic macroRAFT, could provide controlled in-situ self-assembly via copolymerization with hydrophobic monomers into polymer particles. So far, this approach has mostly been studied in dispersion systems and further studies are needed in emulsions. Beside the corresponding mechanistic studies, the prepared latex particles would potentially exhibit smart behaviors by choosing stimuli-responsive monomers...
January 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29331687/probiotics-bacillus-toyonensis-and-saccharomyces-boulardii-improve-the-vaccine-immune-response-to-bovine-herpesvirus-type-5-in-sheep
#8
Talita Bandeira Roos, Carina Martins de Moraes, Régis Tuchtenhagen Sturbelle, Luana Alves Dummer, Geferson Fischer, Fábio Pereira Leivas Leite
There have been significant efforts toward the development of more efficient vaccines for animal health. A strategy that may be used to improve vaccine efficacy is the use of probiotics. Bovine herpesvirus 5 (BoHV-5) is an example of an important animal pathogen for which vaccines have provided only limited protection. In this study, we examined the use of the probiotics Bacillus toyonensis and Saccharomyces boulardii as a potential immune modulator to improve vaccine efficiency. Thirty, 5-month-old lambs were randomly grouped in three lots of 10 each and vaccinated at days 0, 21 and 42 of the experiment...
December 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29331638/comparative-analysis-of-membrane-protein-structure-databases
#9
REVIEW
Kentaro Shimizu, Wei Cao, Gull Saad, Michiru Shoji, Tohru Terada
BACKGROUND: Membrane proteins play important roles in cell survival and cell communication, as they function as transporters, receptors, anchors and enzymes. They are also potential targets for drugs that block receptors or inhibit enzymes related to diseases. Although the number of known structures of membrane proteins is still small relative to the size of the proteome as a whole, many new membrane protein structures have been determined recently. SCOPE OF THE ARTICLE: We compared and analyzed the widely used membrane protein databases, mpstruc, Orientations of Proteins in Membranes(OPM), and PDBTM, as well as the extended dataset of mpstruc based on sequence similarity, the PDB structures whose classification field indicates that they are "membrane proteins" and the proteins with Structural Classification of Proteins (SCOP) class-f domains...
January 10, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29331517/tofu-whey-wastewater-is-a-promising-basal-medium-for-microalgae-culture
#10
Shi-Kai Wang, Xu Wang, Jing Miao, Yong-Ting Tian
Tofu whey wastewater (TWW) is an abundant, nutrient riched and safety wastewater and is regarded as an excellent alternative medium in fermentation. In this study, the feasibility of algal cultivation using TWW as the basal medium was investigated. Results indicated that through simple pH adjustment, TWW presented a better culture performance at autotrophic, heterotrophic, and mixotrophic modes compared with that of regular green algae medium, BG-11. The biomass productivities of Chlorella pyrenoidosa at each trophic mode were 4...
January 4, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29331508/compartmentalized-crosstalk-of-cftr-and-tmem16a-ano1-through-epac1-and-adcy1
#11
Joana Lérias, Madalena Pinto, Roberta Benedetto, Rainer Schreiber, Margarida Amaral, Massimo Aureli, Karl Kunzelmann
Airway epithelial cells express both Ca2+ activated TMEM16A/ANO1 and cAMP activated CFTR anion channels. Previous work suggested a significant crosstalk of intracellular Ca2+ and cAMP signaling pathways, leading to activation of both chloride channels. We demonstrate that in airway epithelial cells, stimulation of purinergic or muscarinic G-protein coupled receptors (GPCRs) activates TMEM16A and CFTR. Additional expression of Gq/11 and phospholipase C coupled GPCRs strongly enhanced the crosstalk between Ca2+- and cAMP-dependent signaling...
January 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29331459/garlic-allium-sativum-l-fed-to-dairy-cows-does-not-modify-the-cheese-making-properties-of-milk-but-affects-the-color-texture-and-flavor-of-ripened-cheese
#12
Giulia Rossi, Stefano Schiavon, Giovanna Lomolino, Claudio Cipolat-Gotet, Alberto Simonetto, Giovanni Bittante, Franco Tagliapietra
Garlic and garlic components have recently been proposed as ruminal activity modulators to reduce the enteric methane emissions of ruminants, but little is known of their influence on milk coagulation properties, nutrient recovery, cheese yield, and sensorial and rheological characteristics of milk and cheese. The present study assessed the effects of garlic and diallyl sulfide supplements on dry matter intake (DMI), productive performance, milk coagulation properties, cheese yield, milk and cheese sensory profiles, and rheological characteristics...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29331411/tailoring-cyanobacterial-cell-factory-for-improved-industrial-properties
#13
REVIEW
Guodong Luan, Xuefeng Lu
Photosynthetic biomanufacturing provides a promising solution for sustainable production of biofuels and biochemicals. Cyanobacteria are among the most promising microbial platforms for the construction of photosynthetic cell factories. Metabolic engineering of cyanobacteria has enabled effective photosynthetic synthesis of diverse natural or non-natural metabolites, while commercialization of photosynthetic biomanufacturing is usually restricted by process and economic feasibilities. In actual outdoor conditions, active cell growth and product synthesis is restricted to narrow light exposure windows of the day-night cycles and is threatened by diverse physical, chemical, and biological environmental stresses...
January 10, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29331137/molecular-dynamics-based-enhanced-sampling-of-collective-variables-with-very-large-time-steps
#14
Pei-Yang Chen, Mark E Tuckerman
Enhanced sampling techniques that target a set of collective variables and that use molecular dynamics as the driving engine have seen widespread application in the computational molecular sciences as a means to explore the free-energy landscapes of complex systems. The use of molecular dynamics as the fundamental driver of the sampling requires the introduction of a time step whose magnitude is limited by the fastest motions in a system. While standard multiple time-stepping methods allow larger time steps to be employed for the slower and computationally more expensive forces, the maximum achievable increase in time step is limited by resonance phenomena, which inextricably couple fast and slow motions...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29331065/component-resolved-diagnostics-to-direct-in-venom-immunotherapy-important-steps-towards-precision-medicine
#15
Simon Blank, Maria Beatrice Bilò, Markus Ollert
Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. In the past, therapeutic decisions based on the measurement of specific IgE (sIgE) levels to whole venom extracts were not always straightforward, especially when the patient was not able to identify the culprit insect...
January 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29330900/overexpression-of-microrna408-enhances-photosynthesis-growth-and-seed-yield-in-diverse-plants
#16
Jiawei Pan, Dahui Huang, Zhonglong Guo, Zheng Kuang, He Zhang, Xinyu Xie, Zengfeng Ma, Shaopei Gao, Manuel T Lerdau, Chengcai Chu, Lei Li
The ability of a plant to produce grain, fruit, or forage depends ultimately on photosynthesis. There have been few attempts, however, to study microRNAs, which are a class of endogenous small RNAs post-transcriptionally programming gene expression, in relation to photosynthetic traits. We focused on miR408, one of the most conserved plant miRNAs, and overexpressed it in parallel in Arabidopsis, tobacco, and rice. The transgenic plants all exhibited increased copper content in the chloroplast, elevated abundance of plastocyanin, and an induction of photosynthetic genes...
January 13, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#17
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330709/in-vitro-and-in-vivo-activity-of-iclaprim-a-diaminopyrimidine-compound-and-potential-therapeutic-alternative-against-pneumocystis-pneumonia
#18
E M Aliouat, E Dei-Cas, N Gantois, M Pottier, C Pinçon, S Hawser, A Lier, D B Huang
Pneumocystis pneumonia is a serious complication that may affect immunosuppressed patients. The absence of reliable and safe therapeutic alternatives to trimethoprim-sulfamethoxazole (TMP/SMX) justifies the search for more effective and less toxic agents. In this study, the in vitro and in vivo anti-Pneumocystis jirovecii activity of iclaprim, a diaminopyrimidine compound that exerts its antimicrobial activity through the inhibition of dihydrofolate reductase (DHFR), as does TMP, was evaluated alone or in combination with SMX...
January 12, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29330689/the-efficiency-of-acoustic-radiation-force-impulse-arfi-elastography-in-the-diagnosis-and-staging-of-carpal-tunnel-syndrome
#19
Harun Arslan, Alpaslan Yavuz, Ferda İlgen, Abdurrahman Aycan, Mesut Ozgokce, Hüseyin Akdeniz, Abdussamet Batur
OBJECTIVES: The aim of the present study was to quantify the stiffness of the median nerve (MN) at the carpal tunnel inlet by acoustic radiation force impulse (ARFI) elastography and to evaluate whether ARFI can be used in diagnosis and staging of carpal tunnel syndrome (CTS). METHODS: Sonographic examinations of 96 wrists in 50 patients were included in the study. The cross-sectional area and stiffness of the MN were quantitatively measured by B-mode ultrasonography (USG) and ARFI...
January 12, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29330529/the-interaction-network-of-the-yidc-insertase-with-the-secyeg-translocon-srp-and-the-srp-receptor-ftsy
#20
Narcis-Adrian Petriman, Benjamin Jauß, Antonia Hufnagel, Lisa Franz, Ilie Sachelaru, Friedel Drepper, Bettina Warscheid, Hans-Georg Koch
YidC/Oxa1/Alb3 are essential proteins that operate independently or cooperatively with the Sec machinery during membrane protein insertion in bacteria, archaea and eukaryotic organelles. Although the interaction between the bacterial SecYEG translocon and YidC has been observed in multiple studies, it is still unknown which domains of YidC are in contact with the SecYEG translocon. By in vivo and in vitro site-directed and para-formaldehyde cross-linking we identified the auxiliary transmembrane domain 1 of E...
January 12, 2018: Scientific Reports
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