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Endobronchial obstruction

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https://www.readbyqxmd.com/read/27909283/-endobronchial-hamartoma-requiring-lobectomy-report-of-a-case
#1
Kyosuke Matsunaga, Yusuke Takanashi, Hironobu Oiki, Takamitsu Hayakawa, Shun Matsuura, Hiroshi Neyatani
We present a rare case of endobronchial hamartoma that required right middle and lower lobectomy. A 59-year-old man presented with cough and sputum lasting for 9 months. Chest X-ray revealed obstructive pneumonia of the right inferior lobe. Chest computed tomography demonstrated an intrabronchial mass lesion, size 12×12 mm, occluding the entrance of the right lower lobe bronchus associated with obstructive pneumonia of the right inferior lobe. Because transbronchial biopsy could not confirm the diagnosis, we performed a right middle and lower lobectomy to diagnose and treat obstructive pneumonia...
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27867582/central-airway-tumors-interventional-bronchoscopy-in-diagnosis-and-management
#2
REVIEW
Chun-Yu Lin, Fu-Tsai Chung
The diagnosis of central airway tumors is usually challenging because of the vague presentations. Advances in visualization technology in bronchoscopy aid early detection of bronchial lesion. Cryotechnology has great impact on endobronchial lesion sampling and provides better diagnostic yield. Airway tumor involvements result in significant alteration in life quality and lead to poor life expectancy. Timely and efficiently use ablation techniques by heat or cold energy provide symptoms relief for central airway obstruction...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27821499/endobronchial-hamartoma-a-rare-disease-with-more-common-presentation
#3
Mohannad Abu Omar, Mouhanna Abu Ghanimeh, Emily Tylski, Timothy Saettele
Hamartomas are the most common benign tumours of the lung with an overall incidence of 0.025-0.32%. They are known to be amalgamation of various tissue types, originating from the embryonic mesoderm. Lung hamartomas typically involve lung parenchyma and only infrequently grows as endobronchial tumours. We present a case of an 80-year-old man who presented to the pulmonary clinic for consultation for breathlessness, recurrent pneumonias and an abnormal radiograph finding. CT scan of the chest showed scattered infiltrates and atelectasis in the left upper lobe...
November 7, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27804985/a-murine-model-of-early-pseudomonas-aeruginosa-lung-disease-with-transition-to-chronic-infection
#4
H K Bayes, N Ritchie, S Irvine, T J Evans
Pseudomonas aeruginosa (PA) remains an important pathogen in patients with cystic fibrosis (CF) lung disease as well as non-CF bronchiectasis and chronic obstructive airways disease. Initial infections are cleared but chronic infection with mucoid strains ensues in the majority of CF patients and specific interventions to prevent this critical infection transition are lacking. The PA bead model has been widely used to study pulmonary P.aeruginosa infection but has limitations in animal husbandry and in accurately mimicking human disease...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27763916/hemodynamic-instability-following-airway-spray-cryotherapy
#5
Alessia Pedoto, Dawn P Desiderio, David Amar, Robert J Downey
BACKGROUND: Spray cryotherapy (SCT) of airway lesions is used to effectively palliate respiratory symptoms related to airway obstruction, but significant intraoperative hemodynamic complications have been noted. We reviewed the experience at a single institution using SCT for the treatment of obstructive airway tumors. METHODS: A retrospective review of a single institution experience with intraoperative and postoperative hemodynamic complications associated with SCT was performed...
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27760423/endosonography-of-a-pulmonary-artery-obstruction-in-echinococcosis
#6
Mark J Schuuring, Peter I Bonta, Michele van Vugt, Frank Smithuis, Otto M van Delden, Jouke T Annema, Kees Stijnis
A 44-year-old woman with a history of pulmonary embolism and abdominal echinococcosis complained of sudden thoracic pain and shortness of breath. A D-dimer of 77.5 mg/l (reference ≤0.5 mg/l) was found. Chest CT scan revealed obstruction of the right lower and middle lobe pulmonary artery (PA). Anticoagulation therapy was initiated for the presumed diagnosis of recurrent pulmonary embolism. However, due to persistent symptoms of dyspnea, follow-up CT angiography of the chest was performed 3 months later. A persistent PA obstruction was found and the presumed diagnosis of embolism was questioned...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27739872/the-clinical-significance-of-collateral-ventilation
#7
Peter B Terry, Richard J Traystman
Oxygen delivery and carbon dioxide removal being critical to cell survival, mammals have developed collateral vascular and ventilation systems to ensure tissue viability. Collateral ventilation, defined as ventilation of alveoli via pathways that bypass normal airways, is present in humans and many other species. The presence of collateral ventilation can be beneficial in certain disease states, while its relative absence can predispose to other diseases. These well defined anatomical pathways contribute little to ventilation in normal humans, but modulate ventilation perfusion imbalance in a variety of diseases including obstructive diseases such as asthma and emphysema...
October 14, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27729785/image-enhanced-bronchoscopic-evaluation-of-bronchial-mucosal-microvasculature-in-copd
#8
Eman Mahmoud Fathy, Hanaa Shafiek, Tamer S Morsi, Bassma El Sabaa, Abdelaziz Elnekidy, Mohamed Elhoffy, Mohamed Samy Atta
BACKGROUND: Bronchial vascular remodeling is an underresearched component of airway remodeling in COPD. Image-enhanced bronchoscopy may offer a less invasive method for studying bronchial microvasculature in COPD. OBJECTIVES: To evaluate endobronchial mucosal vasculature and changes in COPD by image-enhanced i-scan3 bronchoscopy and correlate them pathologically by analyzing bronchial mucosal biopsies. METHODS: This case-control study analyzed 29 COPD patients (41...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27701180/bilateral-endoscopic-lung-volume-reduction-in-patients-with-severe-emphysema
#9
Franziska C Trudzinski, Philipp M Lepper, Daniela Leppert, Frank Langer, Christian Lensch, Monika Flaig, Robert Bals, Heinrike Wilkens, Peter Minko, Sebastian Fähndrich
Reducing hyperinflated areas in chronic obstructive pulmonary disease, either surgically or endoscopically, leads to improvement of functional parameters. It is unclear if bilateral treatment with endobronchial valves (EBV) aiming at total lobar occlusion is beneficial. The aim of this study was to assess the results after staged bilateral endoscopic treatment with EBV. This is a retrospective analysis of patients with severe airflow obstruction, who were treated bilaterally with EBV in two stages, aiming at subsequent atelectasis...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27696747/endobronchial-involvement-as-an-extremely-rare-manifestation-of-the-waldenstr%C3%A3-m-s-disease
#10
Hana Bartáková, Jan Novák, Radek Jakša, Jiří Beneš, Jiří Votruba
Pulmonary infiltration is an infrequent organ involvement in Waldenström's disease (WD). Diffuse infiltration, isolated parenchymatous nodules and pleural effusion are the most common manifestations of WD, while endobronchial mass is extremely rare. We present a case report of a 66-year-old man with a long-standing history of WD, who developed febrile neutropenia after therapy with rituximab, cyclophosphamide and dexamethasone. X-ray and CT scan showed consolidation consistent with right-sided pneumonia. Surprisingly, bronchoscopy revealed an endobronchial tumor obstructing the right lower lobe (RLL) and two smaller granulations...
October 3, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27666549/-interventional-bronchoscopy-for-the-treatment-of-pulmonary-sarcoma
#11
Hongwu Wang, Nan Zhang, Dongmei Li, Hang Zou, Jieli Zhang, Yunzhi Zhou, Xiuyun Bai
BACKGROUND: Pulmonary sarcoma is a rare malignant tumor in soft tissues. Resection is the preferred option to treat this tumor. The aim of this study is to explore the effect of interventional bronchoscopies in the treatment of pulmonary sarcoma if the patient is inoperable. METHODS: Sixteen cases with pulmonary sarcoma were retrospectively reviewed in our hospital from November 2008 to July 2014. The mean age was (53.1±5.4) years old. Rigid bronchoscopy was applied for the first procedure with general anesthesia, and electronic bronchoscopy was used for the second procedure or slight patients...
September 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27603781/endoscopic-lung-volume-reduction-using-endobronchial-valves-in-patients-with-severe-emphysema-and-very-low-fev1
#12
Franziska C Trudzinski, Anna J Höink, Daniela Leppert, Sebastian Fähndrich, Heinrike Wilkens, Thomas P Graeter, Frank Langer, Robert Bals, Peter Minko, Philipp M Lepper
BACKGROUND: Patients with a forced expiratory volume in 1 s (FEV1) below 20% of the predicted normal values (pred.) and either homogeneous emphysema or low diffusing capacity for carbon monoxide (DLCO) have a high risk for adverse events including death when undergoing surgical lung volume reduction. OBJECTIVES: We hypothesized that selected patients can benefit from endoscopic lung volume reduction (eLVR) despite a very low FEV1. METHODS: This study is a retrospective analysis of consecutive patients with severe airflow obstruction, an FEV1 ≤20% of pred...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27595480/safety-of-bronchoscopy-in-patients-with-echocardiographic-evidence-of-pulmonary-hypertension
#13
Gilda Diaz-Fuentes, Bharat Bajantri, Muhammad Adrish
BACKGROUND: Bronchoscopy with transbronchial and endobronchial biopsy and transbronchial needle aspiration is an important diagnostic tool in the pulmonologist's armamentarium. Safety in patients with pulmonary hypertension is controversial and many bronchoscopists consider this as a contraindication for the procedure. OBJECTIVES: To evaluate safety of bronchoscopy in patients with echocardiographic pulmonary hypertension and to compare with patients without it...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27578936/role-of-virtual-and-flexible-bronchoscopy-in-the-management-of-a-case-of-unnoticed-foreign-body-aspiration-presented-as-nonresolving-pneumonia-in-an-adult-female
#14
Ravish Manmohan Kshatriya, Nimit V Khara, Rajiv P Paliwal, Sateesh N Patel
It is not so common to aspirate foreign body in normal adults without any predisposing factors as compared to children and those with the altered neurological state. Endobronchial foreign bodies are one of the causes of obstructive pneumonia and difficult to diagnose as signs and symptoms are often nonspecific. However, once they are diagnosed, they can generally be removed, leading to rapid and drastic resolution of symptoms. Bronchoscopy is the gold standard in the identification and localization of an airway foreign body and also for better management of the ailment...
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27570778/single-incision-video-assisted-anatomical-segmentectomy-with-handsewn-bronchial-closure-for-endobronchial-lipoma
#15
Carlos Galvez, Julio Sesma, Sergio Bolufer, Francisco Lirio, Jose Navarro-Martinez, Maria Galiana, Benno Baschwitz, Maria Jesus Rivera
Endobronchial lipomas are rare benign tumors whose symptoms are usually confused with recurrent infections or even asthma diagnosis, and mostly caused by endobronquial obstructive component which also conditions severity. We report a case of a 60-year-old man with a right-lower lobe upper-segment endobronchial myxoid tumor with uncertain diagnosis. We performed a single incision video-assisted anatomical segmentectomy and wedge bronchoplasty with handsewn closure to achieve complete resection and definitive diagnosis...
August 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27562904/a-long-term-follow-up-investigation-of-endobronchial-valves-in-emphysema-the-live-study-study-protocol-and-six-month-interim-analysis-results-of-a-prospective-five-year-observational-study
#16
Dirk Skowasch, Andreas Fertl, Björn Schwick, Harald Schäfer, Andreas Hellmann, Felix J F Herth
BACKGROUND: Randomized controlled trials indicate that significant lung volume reduction (ELVR) can be obtained with Zephyr® valves by occluding the target lobe in the absence of collateral ventilation, leading to relevant functional benefits in advanced emphysema patients. OBJECTIVES: To observe the long-term effects of endobronchial valve (EBV) implantation in emphysema patients screened by Chartis assessment in the context of daily pulmonology practice. METHODS: The LIVE Study is a prospective, observational, open-label, single-arm, multicenter trial conducted in Germany...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27527123/development-of-a-semiquantitative-histological-score-for-the-diagnosis-of-heaves-using-endobronchial-biopsy-specimens-in-horses
#17
M Bullone, P Hélie, P Joubert, J-P Lavoie
BACKGROUND: Remodeling of the peripheral airways persists during the asymptomatic phase of heaves. Assessing the histology of large bronchi could facilitate the diagnosis of heaves during remission of the disease. HYPOTHESIS: Airway inflammation and remodeling in endobronchial biopsy (EBB) specimens differentiate horses with heaves from controls, independently of their clinical status (exacerbation or remission). ANIMALS: Fourteen healthy horses and 24 horses with heaves...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27492523/comparison-of-endobronchial-ultrasound-and-high-resolution-computed-tomography-as-tools-for-airway-wall-imaging-in-asthma-and-chronic-obstructive-pulmonary-disease
#18
Katarzyna Gorska, Piotr Korczynski, Michal Mierzejewski, Justyna Kosciuch, Malgorzata Zukowska, Marta Maskey-Warzechowska, Rafal Krenke
INTRODUCTION: Airway remodeling in asthma and chronic obstructive pulmonary disease (COPD) results in bronchial wall thickening. Bronchial wall thickness (BWT) can be assessed in high-resolution computed tomography (HRCT) and endobronchial ultrasound (EBUS). AIMS: To compare BWT measured by EBUS and HRCT in patients with mild-to-moderate asthma and COPD, and to evaluate the relationship between the BWT and pulmonary function. METHODS: The study included patients with mild-to-moderate asthma (n = 24), COPD (n = 36) and controls (n = 12)...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27479013/thoracic-extramedullary-hematopoiesis-mimicking-metastatic-cancer
#19
Duc Ha, Xiaoyan Liao, Huan-You Wang, Catriona Jamieson, Marisa Magaña, Samir Makani
Thoracic extramedullary hematopoiesis (EMH) is a rare manifestation in patients with myeloproliferative neoplasm. A 76-year-old woman with a long-standing history of polycythemia vera presented with a 2-month history of worsening dyspnea and left-sided wheezing. A chest computed tomography showed an ill-defined soft tissue mass encasing the left mainstem bronchus causing airway obstruction, associated with paratracheal and paraesophageal lymphadenopathy. Endobronchial ultrasound-guided fine needle aspiration of the soft tissue mass and mediastinoscopy with excisional biopsy of a paratracheal lymph node demonstrated EMH with increased myeloid blasts...
July 29, 2016: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27454473/safety-and-efficacy-of-radial-ebus-for-the-investigation-of-peripheral-pulmonary-lesions-in-patients-with-advanced-copd
#20
Harry D Georgiou, John Taverner, Louis B Irving, Daniel P Steinfort
BACKGROUND: Peripheral pulmonary lesion (PPL) is a common scenario in patients with chronic obstructive pulmonary disease (COPD) and represents a high risk of malignancy. Severe COPD is associated with higher complication rates following percutaneous biopsy, and routine bronchoscopy. Safety and diagnostic performance of radial endobronchial ultrasound bronchoscopy (R-EBUS) in patients with advanced COPD has not been previously assessed. METHODS: We examined a retrospective cohort of patients with advanced COPD undergoing R-EBUS for the evaluation of PPL...
July 2016: Journal of Bronchology & Interventional Pulmonology
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