Read by QxMD icon Read

Talc slurry

Kango Nohara, Kazuto Takada, Eiji Kojima, Kiyoko Ninomiya, Shoko Miyamatsu, Takahiro Shimizu, Tsutomu Sakurai, Takaaki Mizuno, Yuuki Yamashita
BACKGROUND: The choice of an optimal sclerosant for pleurodesis for malignant pleural effusion remains controversial. This retrospective clinical study compared the efficacy and safety of two sclerosants; talc slurry (talc-s) and OK-432. METHODS: We compared the characteristics, 30/90-day success rates, and adverse events in patients with lung adenocarcinoma who underwent pleurodesis by using either OK-432 or talc-s. Propensity score matching was used to compare the two scelrosants...
September 2016: Respiratory Investigation
Susan Walker, Marijana Zubrinic, Christine Massey, Yaron Shargall, Eric Bédard, Gail Darling
BACKGROUND: In a patient population with a limited life expectancy, malignant pleural effusion can significantly impact quality of life (QoL). Different treatment options are available, each with its own effect on QoL. To date, satisfaction with treatment options has not been evaluated. PURPOSE: To evaluate QoL and satisfaction with treatment using patient-reported outcomes for four different treatment strategies. DESIGN: A prospective, cohort study that compared four treatment options: indwelling pleural catheter (IPC); video assisted thoracic surgery (VATS) and IPC; chest tube and talc slurry; and VATS talc poudrage...
July 2, 2016: International Journal of Palliative Nursing
Amelia O Clive, Hayley E Jones, Rahul Bhatnagar, Nancy J Preston, Nick Maskell
BACKGROUND: Malignant pleural effusion (MPE) is a common problem for people with cancer as a result of malignant infiltration of the pleura. It is usually associated with considerable breathlessness. A number of treatment options are available to manage the uncontrolled accumulation of pleural fluid including administration of a pleurodesis agent (either via a chest tube or at thoracoscopy) or indwelling pleural catheter insertion. OBJECTIVES: To ascertain the optimal management strategy for adults with malignant pleural effusion in terms of pleurodesis success...
2016: Cochrane Database of Systematic Reviews
Alexandra Bucknor, Karen Harrison-Phipps, Thomas Davies, Levon Toufektzian
A best evidence topic was written according to a structured protocol. The question addressed was whether silver nitrate (SN) is an effective means of pleurodesis. A total of 42 papers were identified using the reported search, of which 8 represented the best evidence to address the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Three studies assessed the efficacy of SN in inducing pleurodesis in patients with malignant pleural effusion (MPE)...
October 2015: Interactive Cardiovascular and Thoracic Surgery
Srinivas Mummadi, Anusha Kumbam, Peter Y Hahn
BACKGROUND: Malignant Pleural Effusion (MPE) is common with advanced malignancy. Palliative care with minimal adverse events is the cornerstone of management. Although talc pleurodesis plays an important role in treatment, the best modality of talc application remains controversial.   OBJECTIVE: To compare rates of successful pleurodesis, rates of respiratory and non-respiratory complications between thoracoscopic talc insufflation/poudrage (TTI) and talc slurry (TS)...
2014: F1000Research
Sam A Walling, Hajime Kinoshita, Susan A Bernal, Nick C Collier, John L Provis
A cementitious system for the immobilisation of magnesium rich Magnox sludge was produced by blending an Mg(OH)2 slurry with silica fume and an inorganic phosphate dispersant. The Mg(OH)2 was fully consumed after 28 days of curing, producing a disordered magnesium silicate hydrate (M-S-H) with cementitious properties. The structural characterisation of this M-S-H phase by (29)Si and (25)Mg MAS NMR showed clearly that it has strong nanostructural similarities to a disordered form of lizardite, and does not take on the talc-like structure as has been proposed in the past for M-S-H gels...
May 7, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Suk Ju Cho, Su Wan Kim, Jee Won Chang
Chemical pleurodesis is widely recommended in the treatment of pulmonary air leak of different etiologies as well as malignant pleural effusions and chylothorax. Conventional chemical pleurodesis using erythromycin, tetracycline, hydrophilic fumed silica, autologous blood and talc slurry has been standardized, and its complications, including high fever, intractable chest pain, and acute lung injury, seem to be frequent. Viscum album extract is a new chemical agent for pleurodesis, and only a few studies have reported outcomes of such chemical pleurodesis in the treatment of malignant pleural effusion...
2014: Multidisciplinary Respiratory Medicine
Serkan Özkul, Akif Turna, Ahmet Demirkaya, Burcu Aksoy, Kamil Kaynak
BACKGROUND: Chemical pleurodesis can be palliative for recurrent, symptomatic pleural effusions in patients who are not candidate for a thoracic surgical procedure. We hypothesized that effective pleurodesis could be accomplished with a rapid method of pleurodesis as effective as the standard method. METHODS: A prospective randomized 'non-inferiority' trial was conducted in 96 patients with malignant pleural effusion (MPE) who are not potentially curable and/or not amenable to any other surgical intervention...
December 2014: Journal of Thoracic Disease
Liju Ahmed, Hugh Ip, Deepak Rao, Nishil Patel, Farinaz Noorzad
Malignant pleural effusions cause significant morbidity, but there is no gold standard minimally invasive treatment. A new therapeutic approach combines talc pleurodesis and indwelling pleural catheters (IPCs) to enable outpatient management. This case series summarizes the safety and efficacy data of all patients (24) with a symptomatic malignant pleural effusion who underwent talc pleurodeses via IPCs between December 2010 and July 2013. Successful pleurodesis was achieved in 22 procedures (92%). There was one empyema, one hydropneumothorax, one recurrent effusion, and two minor complications: one drain site wound infection and one complaint of chest pain...
December 2014: Chest
Rahul Bhatnagar, Magda Laskawiec-Szkonter, Hania E G Piotrowska, Brennan C Kahan, Clare E Hooper, Helen E Davies, John E Harvey, Robert F Miller, Najib M Rahman, Nick A Maskell
INTRODUCTION: The management of recurrent malignant pleural effusions (MPE) can be challenging. Various options are available, with the most efficacious and widely used being talc pleurodesis. Talc can either be applied via a chest drain in the form of slurry, or at medical thoracoscopy using poudrage. Current evidence regarding which method is most effective is conflicting and often methodologically flawed. The TAPPS trial is a suitably powered, multicentre, open-label, randomised controlled trial designed to compare the pleurodesis success rate of medical thoracoscopy and talc poudrage with chest drain insertion and talc slurry...
2014: BMJ Open
Edward T H Fysh, Rajesh Thomas, Catherine A Read, Ben C H Kwan, Ben C H Lam, Elaine Yap, Fiona C Horwood, Pyng Lee, Francesco Piccolo, Ranjan Shrestha, Luke A Garske, David C L Lam, Andrew Rosenstengel, Michael Bint, Kevin Murray, Nicola A Smith, Y C Gary Lee
INTRODUCTION: Malignant pleural effusion can complicate most cancers. It causes breathlessness and requires hospitalisation for invasive pleural drainages. Malignant effusions often herald advanced cancers and limited prognosis. Minimising time spent in hospital is of high priority to patients and their families. Various treatment strategies exist for the management of malignant effusions, though there is no consensus governing the best choice. Talc pleurodesis is the conventional management but requires hospitalisation (and substantial healthcare resources), can cause significant side effects, and has a suboptimal success rate...
2014: BMJ Open
Pedro de Araujo, Ricardo Terra, Paulo Pêgo-Fernandes, Rodrigo Chate
Pleural DiseaseSESSION TYPE: Original Investigation SlidePRESENTED ON: Wednesday, October 29, 2014 at 02:45 PM - 04:15 PMPURPOSE: To investigate the impact of the pleural catheter position on the success of bedside pleurodesis, residual pleural space after effusion's drainage and acumulation of effusion pos pleurodesis in patientes with recurrent malignant pleural effusions (RMPEs).METHODS: We retrospectively analysed 80 patients with RMPEs treated with pleurodesis (talc or silver nitrate slurry) at our hospital between June 2009 and September 2013...
October 1, 2014: Chest
Nusret Ramić, Goran Krdžalić, Nermin Mušanović, Ferid Konjić, Sefika Umihanić, Suada Ramić, Jasminka Mustedanagić-Mujanović, Farid Ljuca, Enver Zerem
AIM: To determine the efficiency and safety of talc pleurodesis in treating the malignant pleural effusion and recurrent spontaneous pneumothorax. METHODS: The study included 54 patients with malignant pleural effusion and recurrent spontaneous pneumothorax, who underwent talc pleurodesis using the "talc slurry" method of pleural talc obliteration. RESULTS: Pleurodesis was successful in 52 (96%) patients. The average duration of thoracic drainage was 4...
August 2014: Medicinski Glasnik
Huan Xia, Xiao-Juan Wang, Qiong Zhou, Huan-Zhong Shi, Zhao-Hui Tong
BACKGROUND: Talc pleurodesis has been widely used to control malignant pleural effusion; however, it is still not clear whether talc pleurodesis is more effective than other local therapies. We performed a meta-analysis to evaluate the efficacy and safety of talc pleurodesis in the management of malignant pleural effusion. METHODS: PubMed, Embase, and Web of Science were searched for English-language studies of clinical controlled trials comparing talc pleurodesis with control therapies until August 8, 2013...
2014: PloS One
Konstantinos Zarogoulidis, Paul Zarogoulidis, Kaid Darwiche, Kosmas Tsakiridis, Nikolaos Machairiotis, Ioanna Kougioumtzi, Nikolaos Courcoutsakis, Eirini Terzi, Bojan Zaric, Haidong Huang, Lutz Freitag, Dionysios Spyratos
Involvement of the pleura in lung cancer is a common manifestation accompanying with reduced life expectancy. Symptoms relief and improvement of the quality of life are the primary goals of the management of malignant pleural effusion (MPE). Histological confirmation is essential for optimal patient management. Lung cancer patients, with life expectancy more than 3 months, resistant to chemotherapy should be treated with thoracentesis, intercoastal tube drainage and installation of a sclerosant agent or pleurodesis through thoracospopic procedures or placement of an indwelling pleura catheter...
September 2013: Journal of Thoracic Disease
Cecilia Menna, Claudio Andreetti, Mohsen Ibrahim, Giulio Maurizi, Camilla Poggi, Rocco Barile, Francesco Cassiano, Erino A Rendina
BACKGROUND: Chemical pleurodesis is the procedure of choice in the management of recurrent malignant pleural effusions (MPE). Talc is probably the most effective sclerosant, with a success rate of 80%. The aim of this study is to demonstrate the effectiveness of silver nitrate solution (SNS) pleurodesis after an unsuccessful thoracoscopic talc poudrage. METHODS: Between 2011 and 2013 one hundred and nine patients with unilateral MPE underwent thoracoscopic talc poudrage...
2013: BioMed Research International
Grzegorz Gawron, Jacek Gabryś, Adam Barczyk
INTRODUCTION: Chemical pleurodesis is an accepted palliative therapy for patients with recurrent and symptomatic pleural effusion. The aim of the study is to present our own experiences with a less invasive variant of this procedure performed with talc slurry administered via a chest tube under local anaesthesia. Available medical literature in Polish does not contain information about this type of pleurodesis. MATERIAL AND METHODS: During 2005-2011 in the Pulmonology and Respiratory Rehabilitation Department we hospitalized and diagnosed 162 patients with pleural fluid...
2013: Pneumonologia i Alergologia Polska
Takeo Inoue, Atsuko Ishida, Miho Nakamura, Hiroki Nishine, Masamichi Mineshita, Teruomi Miyazawa
OBJECTIVE: Malignant pleural effusions are commonly treated with tube drainage followed by chemical pleurodesis to maintain the patient's quality of life. While talc is now accepted to be a worldwide gold-standard sclerosing agent for treating malignant pleural effusion, it is not yet approved in Japan. Instead, many patients are administered OK-432 for pleurodesis, which carries the risk of complications such as high-grade fever, chest pain, anaphylactic shock, interstitial pneumonia and acute renal failure...
2013: Internal Medicine
Helen E Davies, Eleanor K Mishra, Brennan C Kahan, John M Wrightson, Andrew E Stanton, Anur Guhan, Christopher W H Davies, Jamal Grayez, Richard Harrison, Anjani Prasad, Nicola Crosthwaite, Y C Gary Lee, Robert J O Davies, Robert F Miller, Najib M Rahman
CONTEXT: Malignant pleural effusion causes disabling dyspnea in patients with a short life expectancy. Palliation is achieved by fluid drainage, but the most effective first-line method has not been determined. OBJECTIVE: To determine whether indwelling pleural catheters (IPCs) are more effective than chest tube and talc slurry pleurodesis (talc) at relieving dyspnea. DESIGN: Unblinded randomized controlled trial (Second Therapeutic Intervention in Malignant Effusion Trial [TIME2]) comparing IPC and talc (1:1) for which 106 patients with malignant pleural effusion who had not previously undergone pleurodesis were recruited from 143 patients who were treated at 7 UK hospitals...
June 13, 2012: JAMA: the Journal of the American Medical Association
Nariman Helmy, Yosri Akl, Safy Kaddah, Hamed Abd El Hafiz, Hisham El Makhzangy
INTRODUCTION: Chemical pleurodesis is an effective treatment for malignant effusion and pneumothorax. Although this mode of therapy is less widely accepted in treatment of patients with hepatic hydrothorax, the need for palliative treatment in such patients encouraged us to do this work. The aim of study was analysing the outcome of chemical pleurodesis using bovoiodine, Vibramycin and talc slurry in treatment of hepatic hydrothorax. MATERIAL AND METHODS: A case series randomized study including 23 patients with symptomatic right side hepatic hydrothorax not responding to medical treatment and repeated thoracocentesis was conducted...
June 30, 2010: Archives of Medical Science: AMS
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"