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https://www.readbyqxmd.com/read/29031220/effects-of-glyphosate-based-herbicide-on-pintado-da-amaz%C3%A3-nia-hematology-histological-aspects-metabolic-parameters-and-genotoxic-potential
#1
Fernando Rafael de Moura, Ritane Rose da Silva Lima, Ana Paula Simões da Cunha, Patrícia da Costa Marisco, Danilo Henrique Aguiar, Marina Mariko Sugui, Adilson Paulo Sinhorin, Valéria Dornelles Gindri Sinhorin
Roundup Original(®) is an herbicide widely used in Mato Grosso's agriculture and it may contamine water bodies, being an unforeseen xenobiotic to aquatic organisms, particularly fish. This study investigated the effects on the hybrid fish jundiara (Leiarius marmoratus×Pseudoplatystoma reticulatum) of an environmentally relevant exposure to this herbicide. Glucose levels in liver, muscle and plasma decreased after exposure to 1.357mgL(-1) of Roundup Original(®) (glyphosate nominal concentration), while glycogen levels reduced in liver and muscle for different times...
September 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29031048/trends-in-perinatal-health-in-metropolitan-france-from-1995-to-2016-results-from-the-french-national-perinatal-surveys
#2
B Blondel, B Coulm, C Bonnet, F Goffinet, C Le Ray
OBJECTIVE: To study trends in the main indicators of perinatal health, medical practices and risk factors in France since 1995. POPULATION AND METHOD: All live births during one week in 1995 (n=13,318), 2003 (n=14,737), 2010 (n=14,903) and 2016 (n=13,384). Data were from interviews of women in postpartum wards and from medical records and were compared between years. RESULTS: Between 1995 and 2016, maternal age and body mass index increased steadily...
October 9, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/29028910/assessment-of-changes-in-lactate-concentration-with-intravascular-microdialysis-during-high-risk-cardiac-surgery-using-the-trend-interchangeability-method
#3
C Gouëzel, E Lorne, V Bonnet, S Fradin, V Saplacan, J-L Gérard, J-L Hanouz, J-L Fellahi, M-O Fischer
Background: Blood lactate is a strong predictor of mortality, and repeated blood lactate assays are recommended during surgery in high-risk patients. We hypothesized that the use of intravascular microdialysis incorporated in a central venous catheter would be interchangeable with the reference blood gas technique to monitor changes in blood lactate. Methods: Microdialysis and central venous blood lactate measurements were recorded simultaneously in high-risk cardiac surgical patients...
October 3, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29028602/toxicity-of-zno-nanoparticles-nps-to-a549-cells-and-a549-epithelium-in-vitro-interactions-with-dipalmitoyl-phosphatidylcholine-dppc
#4
Tong He, Jimin Long, Juan Li, Liangliang Liu, Yi Cao
Once inhaled, nanoparticles (NPs) will first interact with lung surfactant system, which may influence the colloidal aspects of NPs and consequently the toxic potential of NPs to pulmonary cells. In this study, we investigated the effects of dipalmitoyl phosphatidylcholine (DPPC), the major component in lung surfactant, on stability and toxicity of ZnO NPs. The presence of DPPC increased the UV-vis spectra, hydrodynamic size, Zeta potential and dissolution rate of ZnO NPs, which indicates that DPPC might interact with NPs and affect the colloidal stability of NPs...
October 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29028143/functional-analysis-of-toxoplasma-lactate-dehydrogenases-suggests-critical-roles-of-lactate-fermentation-for-parasite-growth-in-vivo
#5
Ningbo Xia, Jichao Yang, Shu Ye, Lihong Zhang, Yanqin Zhou, Junlong Zhao, L David Sibley, Bang Shen
Glycolysis was thought to be the major pathway of energy supply in both fast replicating tachyzoites and slowly growing bradyzoites of Toxoplasma gondii. However its biological significance has not been clearly verified. The genome of T. gondii encodes two lactate dehydrogenases (LDH), which are differentially expressed in tachyzoites and bradyzoites. In this study, we knocked out the two LDH genes individually and in combination, and found that neither gene was required for tachyzoite growth in vitro under standard growth conditions...
October 13, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29028110/melanoma-staging-evidence-based-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#6
Jeffrey E Gershenwald, Richard A Scolyer, Kenneth R Hess, Vernon K Sondak, Georgina V Long, Merrick I Ross, Alexander J Lazar, Mark B Faries, John M Kirkwood, Grant A McArthur, Lauren E Haydu, Alexander M M Eggermont, Keith T Flaherty, Charles M Balch, John F Thompson
Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria...
October 13, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29028073/polyphenol-epigallocatechin-3-gallate-alleviates-high-glucose-induced-h9c2-cell-damage-through-pi3k-akt-pathway
#7
Z-M Wang, C-Y Zhong, G-J Zhao
OBJECTIVE: The aim of this work was to study the protective effect of polyphenol epigallocatechin-3-gallate (EGCG) on high glucose-induced oxidative damage of H9C2 cells and to investigate the relationship between this effect and phosphatidyl inositol 3 kinase-serine/threonine kinase (P13K/Akt) signal transduction pathway. MATERIALS AND METHODS: H9C2 cells were used as objects of study, 350 mM glucose serum-free medium was used as the high glucose molding condition, and LY294002 (10 μM) was used as the PI3K/Akt inhibitor...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027817/oral-supplementation-of-parturient-mothers-with-vitamin-d-and-its-effect-on-25ohd-status-of-exclusively-breastfed-infants-at-6-months-of-age-a-double-blind-randomized-placebo-controlled-trial
#8
Prasanna Naik, M M A Faridi, Prerna Batra, S V Madhu
BACKGROUND: Exclusively breastfed infants are at increased risk of vitamin D deficiency and many lactating mothers have been found deficient in 25OHD stores. OBJECTIVE: To compare serum vitamin D levels in exclusively breastfed infants at 6 months of age with or without oral supplementation of 600,000 IU of vitamin D3 to mothers in early postpartum period. METHODS: Exclusively breastfeeding term parturient mothers were randomized 24-48 hours following delivery to receive either 600,000 IU of vitamin D3 (Cholecalciferol) over 10 days in a dose of 60,000 IU/day or placebo...
October 13, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29027434/-protective-effect-of-notoginsenoside-r1-on-neuron-injury-induced-by-ogd-r-through-atf6-akt-signaling-pathway
#9
Qian-Ling Hou, Yan Wang, Ying-Bo Li, Xue-Lian Hu, Sha-Li Wang
Notoginsenoside R1(NGR1),a critical compound in traditional herb Panax notoginseng, is a kind of estrogen receptor agonist.It is reported to exhibit anti-apoptotic,anti-oxidative and anti-inflammatory properties activity, so it is widely used for treatment of various diseases.In order to investigate the potential neuroprotective effect of NGR1 in hypoxic-ischemic brain damage(HIBD), primary cortical neurons were used in this study to establish oxygen-glucose deprivation/reoxygenation(OGD/R) injury models. They were treated with NGR1 and estrogen receptor inhibitor ICI-182780 respectively, then the neuronal survival, cell membrane integrity and apoptosis were assessed by MTT assay,lactate dehydrogenase test(LDH) and Hoechst 33342 stain respectively, while the protein expression levels of ATF6α,p-Akt,Akt,Bax and Cleaved Caspase-3 were measured by Western blotting...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29027266/reliable-and-sensitive-physical-testing-of-elite-trapeze-sailors
#10
Jonathan Bay, Jens Bojsen-Møller, Nikolai B Nordsborg
It was investigated, if a newly developed discipline specific test for elite-level trapeze sailors is reli-able and sensitive. Furthermore, the physical demands of trapeze sailing were examined. In part 1, nine national team athletes were accustomed to a simulated sailing test, which subsequently was completed on four occasions to determine test reliability and sensitivity to manipulations in body-weight. Rope-pulling mean power output (MPO), oxygen consumption (VO2 ), heart rate (HR) and blood lactate values were acquired in all trials...
October 13, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29026946/psma-targeted-radioligandtherapy-in-metastatic-castration-resistant-prostate-cancer-after-chemotherapy-abiraterone-and-or-enzalutamide-a-retrospective-analysis-of-overall-survival
#11
K Rahbar, M Boegemann, A Yordanova, M Eveslage, M Schäfers, M Essler, H Ahmadzadehfar
AIM: Our aim was to evaluate overall survival and parameters prognosticating longer survival in a large and homogeneous group of patients treated with (177)Lu-PSMA-617 radioligand therapy with heavily pretreated advanced metastatic castration resistant prostate cancer. METHODS: A total of 104 patients were treated with 351 cycles of (177)Lu-PSMA-617. Prostate specific antigen (PSA) changes after the first cycle of therapy were documented prior to a second cycle...
October 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29026888/korean-shock-society-septic-shock-registry-a-preliminary-report
#12
Tae Gun Shin, Sung Yeon Hwang, Gu Hyun Kang, Won Young Kim, Seung Mok Ryoo, Kyuseok Kim, You Hwan Jo, Sung Phil Chung, Young Seon Joo, Jin Ho Beom, Sung-Hyuk Choi, Young Hoon Yoon, Woon Yong Kwon, Tae Ho Lim, Kap Su Han, Han Sung Choi, Gil Joon Suh
OBJECTIVE: To evaluate the clinical characteristics, therapeutic interventions, and outcomes of patients with septic shock admitted to the emergency department (ED). METHODS: This study was a preliminary, descriptive analysis of a prospective, multi-center, observational registry of the EDs of 10 hospitals participating in the Korean Shock Society. Patients aged 19 years or older who had a suspected or confirmed infection and evidence of refractory hypotension or hypoperfusion were included...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29026733/safety-of-a-new-synbiotic-starter-formula
#13
Yvan Vandenplas, Antonis Analitis, Chara Tziouvara, Athina Kountzoglou, Anastasia Drakou, Manos Tsouvalas, Antigoni Mavroudi, Ioannis Xinias
PURPOSE: Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding. METHODS: The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months. RESULTS: The median age of the infants at inclusion was 0...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29026730/important-role-of-medical-training-curriculum-to-promote-the-rate-of-human-milk-feeding
#14
REVIEW
Yong Joo Kim
The rate of human milk feeding has been decreasing despite the diverse efforts of many physicians and nurses, as well as numerous professional organizations and various international health institutions. The number of physicians and nurses who can provide proper guidance for human milk feeding and offer appropriate knowledge and techniques to allow the most beneficial and convenient manner of breastfeeding is quite deficient. It is suggested that physicians and nurses be trained to teach and educate about the medical importance of human milk feeding to lactating mothers...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29026707/nadph-oxidase-mediates-%C3%AE-amyloid-peptide-induced-neuronal-death-in-mouse-cortical-cultures
#15
Kee-Oh Chay, Kyoung Young Nam Koong, Shinae Hwang, Jong-Keun Kim, Choon Sang Bae
β-Amyloid peptide (Aβ) is the main component of senile plaques in patients with Alzheimer's disease, and is known to be a main pathogenic factor of the disease. Recent evidence indicates that activation of NADPH oxidase (NOX) in microglia or astrocytes may be a source of Aβ-induced reactive oxygen species (ROS). We investigated the role of neuronal NOX in Aβ-induced neuronal death in mouse mixed cortical cultures. Cell death was assessed by measuring lactate dehydrogenase efflux to bathing media 24 or 48 hr after exposure to Aβ25-35, a fragment of Aβ with an equivalent neurotoxic effect...
September 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/29026604/transglucosidase-improves-the-bowel-movements-in-type-2-diabetes-mellitus-patients-a-preliminary-randomized-double-blind-placebo-controlled-study
#16
Akihiro Shimozato, Makoto Sasaki, Naotaka Ogasawara, Yasushi Funaki, Masahide Ebi, Chiho Goto, Satoshi Koikeda, Takashi Joh, Kunio Kasugai
BACKGROUND: Recent studies have highlighted the relationship between gut microbiota and bowel movements. OBJECTIVE: We aimed to evaluate transglucosidase treatment efficacy for bowel movements in patients with type 2 diabetes mellitus and to clarify the relationship between bowel movements, dietary habits, gut microbiota and fecal short-chain fatty acids. METHODS: In this randomized double-blind, placebo-controlled study, 66 patients received placebo or transglucosidase (300 or 900 mg/day) orally, for 12 weeks...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026537/negative-effects-of-long-term-feeding-of-high-grain-diets-to-lactating-goats-on-milk-fat-production-and-composition-by-regulating-gene-expression-and-dna-methylation-in-the-mammary-gland
#17
Ping Tian, Yanwen Luo, Xian Li, Jing Tian, Shiyu Tao, Canfeng Hua, Yali Geng, Yingdong Ni, Ruqian Zhao
BACKGROUND: It is well known that feeding a high concentrate (HC) diet to lactating ruminants likely induces subacute ruminal acidosis (SARA) and leads to a decrease in milk fat production. However, the effects of feeding a HC diet for long periods on milk fatty acids composition and the mechanism behind the decline of milk fat still remains poorly understood. The aim of this study was to investigate the impact of feeding a HC diet to lactating dairy goats on milk fat yield and fatty acids composition with an emphasis on the mechanisms underlying the milk fat depression...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29026496/the-effects-of-gestational-and-lactational-exposure-to-nonylphenol-on-c-jun-and-c-fos-expression-and-learning-and-memory-in-hippocampus-of-male-f1-rat
#18
Yu Jie, Wang Pan, Yan Wenxia, Gao Feng, He Liting, Li Wenmei, Xu Jie
OBJECTIVES: To investigate the effects of Nonylphenol (NP) in pups from dams exposed during gestational and lactational periods on immediate early genes (c-jun, c-fos) in hippocampus and the learning and memory of F1 rats. MATERIALS AND METHODS: Twenty eight pregnant dams, stratified by pregnancy date, were randomly assigned into 4 groups, which were gavaged with NP at the doses of 50 mg/kg/day, 100 mg/kg/day, 200 mg/kg/day and groundnut oil, respectively. Step-down avoidance test, and learning and memory effects of NP were evaluated on 8-weeks-old pups...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29026432/timely-initiation-of-breastfeeding-and-its-association-with-birth-place-in-ethiopia-a-systematic-review-and-meta-analysis
#19
REVIEW
Animut Alebel, Getiye Dejenu, Getachew Mullu, Nurilign Abebe, Tenaw Gualu, Setegn Eshetie
BACKGROUND: Timely initiation of breastfeeding is defined as putting the newborn to the breast within 1 h of birth. In Ethiopia, different studies have been conducted to assess the prevalence of timely initiation of breastfeeding and associated factors. The findings of these studies were inconsistent and characterized by great variability. Therefore, the aim of this systematic review and meta-analysis was to estimate the pooled prevalence of timely initiation of breastfeeding and its association with birth place in Ethiopia using the available studies...
2017: International Breastfeeding Journal
https://www.readbyqxmd.com/read/29026431/enablers-and-barriers-to-success-among-mothers-planning-to-exclusively-breastfeed-for-six-months-a-qualitative-prospective-cohort-study-in-kwazulu-natal-south-africa
#20
Ngcwalisa Amanda Jama, Aurene Wilford, Zandile Masango, Lyn Haskins, Anna Coutsoudis, Lenore Spies, Christiane Horwood
BACKGROUND: Exclusive breastfeeding (EBF) for the first six months of life is the most important determinant of child health and development, and is the recommended feeding practice for all mothers. However, EBF rates remain low in South Africa. This study aimed to prospectively explore enablers or barriers to success among mothers who planned to exclusively breastfeed their infants for the first six months of life, in KwaZulu-Natal, South Africa. METHODS: A qualitative, longitudinal cohort design was adopted...
2017: International Breastfeeding Journal
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