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https://www.readbyqxmd.com/read/29691992/breastfeeding-and-growth-during-infancy-among-offspring-of-mothers-with-gestational-diabetes-mellitus-a-prospective-cohort-study
#1
E P Gunderson, L C Greenspan, M S Faith, S R Hurston, C P Quesenberry
BACKGROUND: Breastfeeding (BF) may protect against obesity and type 2 diabetes mellitus in children exposed to maternal diabetes in utero, but its effects on infant growth among this high-risk group have rarely been evaluated. OBJECTIVES: The objective of this study was to evaluate BF intensity and duration in relation to infant growth from birth through 12 months among offspring of mothers with gestational diabetes mellitus (GDM). METHODS: Prospective cohort of 464 GDM mother-infant dyads (28% White, 36% Hispanic, 26% Asian, 8% Black, 2% other)...
April 24, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29691755/my-patient-has-received-fluid-how-to-assess-its-efficacy-and-side-effects
#2
REVIEW
Xavier Monnet, Jean-Louis Teboul
Many efforts have been made to predict, before giving fluid, whether it will increase cardiac output. Nevertheless, after fluid administration, it is also essential to assess the therapeutic efficacy and to look for possible adverse effects. Like for any drug, this step should not be missed. Basically, volume expansion is aimed at improving tissue oxygenation and organ function. To assess this final result, clinical signs are often unhelpful. The increase in urine output in case of acute kidney injury is a poor marker of the kidney perfusion improvement...
April 24, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29691694/-which-medications-are-safe-while-breastfeeding-a-synopsis-for-the-anesthetist-obstetrician-and-pediatrician
#3
REVIEW
Arabella Fischer, Clemens Ortner, Thomas Hartmann, Stefan Jochberger, Klaus Ulrich Klein
Pharmacokinetic data on drug administration during lactation are often inconsistent or missing. For legal reasons medicinal drug product information generally advises to interrupt breastfeeding for 24 h after medication intake. However this is not standard of care in clinical practice as the mother should be instructed to initiate breastfeeding as soon as possible after giving birth. At the same time the medication exposure over the breast milk for the newborn should be minimized. Aim of this article is to summarize pharmacokinetic data and to give important clinical information on medications frequently administered during the lactation period...
April 24, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29691195/d-lactate-electrochemical-biosensor-prepared-by-immobilization-of-thermostable-dye-linked-d-lactate-dehydrogenase-from-candidatus-caldiarchaeum-subterraneum
#4
Takenori Satomura, Junji Hayashi, Hiroaki Sakamoto, Takuro Nunoura, Yoshihiro Takaki, Ken Takai, Hideto Takami, Toshihisa Ohshima, Haruhiko Sakuraba, Shin-Ichiro Suye
A stable d-lactate electrochemical sensing system was developed using a dye-linked d-lactate dehydrogenase (Dye-DLDH) from an uncultivated thermophilic archaeon, Candidatus Caldiarchaeum subterraneum. To develop the system, the putative gene encoding the Dye-DLDH from Ca. Caldiarchaeum subterraneum was overexpressed in Escherichia coli, and the expressed product was purified. The recombinant enzyme was a highly thermostable Dye-DLDH that retained full activity after incubation for 10 min at 70°C. The electrode for detection of d-lactate was prepared by immobilizing the thermostable Dye-DLDH and multi-walled carbon nanotube (MWCNT) within Nafion membrane...
April 21, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29691084/measuring-milk-a-call-for-change-in-quantifying-breastfeeding-behaviour
#5
EDITORIAL
Philippa Davie, Debra Bick, Joseph Chilcot
No abstract text is available yet for this article.
April 12, 2018: Midwifery
https://www.readbyqxmd.com/read/29690859/a-comparison-of-oxidative-lactate-metabolism-in-traumatically-injured-brain-and-control-brain
#6
Ibrahim Jalloh, Adel Helmy, Duncan Howe, Richard J Shannon, Peter Grice, Andrew Mason, Clare N Gallagher, Michael Murphy, John Pickard, David Menon, Thomas Adrian Carpenter, Peter John Hutchinson, Keri Carpenter
Metabolic abnormalities occur after traumatic brain injury (TBI). Glucose is conventionally regarded as the major energy substrate, although lactate can also be an energy source. We compared 3-13C lactate metabolism in TBI with "normal" control brain and muscle, measuring 13C-glutamine enrichment to assess tricarboxylic acid (TCA) cycle metabolism. Microdialysis catheters in 9 severe TBI patients' brains, 5 non-TBI brain surgical patients, and 5 resting muscle (non-TBI) patients were perfused (24h in brain, 8h in muscle) with 8 mmol/L sodium 3‑13C lactate...
April 25, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29690753/correlation-between-regional-tissue-perfusion-saturation-and-lactate-level-during-cardiopulmonary-bypass
#7
Yoon-Sook Lee, Woon Young Kim, Ji Won Yoo, Hyun Don Jung, Too Jae Min
Background: Cardiopulmonary bypass (CPB) can cause systemic hypoperfusion, which remains undetected by routine monitoring of physiological parameters. Noninvasive tissue perfusion monitoring offers a clinical benefit by detecting low systemic perfusion. In this study, we tried to evaluate whether regional tissue perfusion saturation reflects systemic hypoperfusion during CPB. Methods: This retrospective study included 29 patients with American Society of Anesthesiologists physical status II-III, who required cardiac surgery with CPB...
April 25, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29690651/betulin-3-28-diphosphate-as-a-component-of-combination-cytostatic-drugs-for-the-treatment-of-ehrlich-ascites-carcinoma-in-vitro-and-in-vivo-experiments
#8
Olga Vorobyova, Olga Deryabina, Darina Malygina, Nadezhda Plotnikova, Anna Solovyeva, Kseniya Belyaeva, Nina Melnikova
The activity of betulin-3,28-diphosphate (BDP) in combination with the cytostatics such as 5-fluorouracil (5-FU) and hydrazine sulfate (HS) was demonstrated by using the transplanted Ehrlich ascites carcinoma (EAC) in mice. The dose-dependent effect of combination drugs BDP + HS and BDP + 5-FU was revealed by in vitro experiments on rats. The synergetic effect of HS and BDP on oxidative stress and energy metabolism was established. The malonic dialdehyde (MDA) level both in plasma and erythrocytes decreased by 87 ± 2%, and the superoxide dismutase (SOD) activity increased by 105 ± 7% in comparison with the control...
April 23, 2018: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/29690542/infant-feeding-attitudes-and-practices-of-spanish-low-risk-expectant-women-using-the-iifas-iowa-infant-feeding-attitude-scale
#9
María Del Carmen Suárez Cotelo, María Jesús Movilla-Fernández, Paula Pita-García, Silvia Novío
The Iowa Infant Feeding Attitude Scale (IIFAS) has been shown to have good psychometric properties for English-speaking populations, but it has not been validated among low-risk pregnant women in Spain. The aim of this study was to assess the reliability and validity of the translated version of the IIFAS in order to examine infant feeding attitudes in Spanish women with an uncomplicated pregnancy. Low-risk expectant women ( n = 297) were recruited from eight primary public health care centres in Galicia (Spain)...
April 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29690538/adipose-tissue-lactate-clearance-but-not-blood-lactate-clearance-is-associated-with-clinical-outcome-in-sepsis-or-septic-shock-during-the-post-resuscitation-period
#10
Ioannis Ilias, Sofia Apollonatou, Dimitra-Argyro Vassiliadi, Nikitas Nikitas, Maria Theodorakopoulou, Argyris Diamantakis, Anastasia Kotanidou, Ioanna Dimopoulou
No study has directly measured tissue lactate clearance in patients with sepsis during the post-resuscitation period. In this study we aimed to assess in ICU patients with sepsis ( n = 32) or septic shock ( n = 79)—during the post-resuscitation phase—the relative kinetics of blood/tissue lactate clearances and to examine whether these are associated with outcome. We measured serially—over a 48-h period—blood and adipose tissue interstitial fluid lactate levels (with microdialysis) and we calculated lactate clearance...
April 21, 2018: Metabolites
https://www.readbyqxmd.com/read/29689567/ampk-contributes-to-cardioprotective-effects-of-pterostilbene-against-myocardial-ischemia-reperfusion-injury-in-diabetic-rats-by-suppressing-cardiac-oxidative-stress-and-apoptosis
#11
Ramoji Kosuru, Yin Cai, Vidya Kandula, Dan Yan, Chunyan Wang, Hong Zheng, Yalan Li, Michael G Irwin, Sanjay Singh, Zhengyuan Xia
BACKGROUND/AIMS: Pterostilbene (PT) exerts antidiabetic effects by decreasing blood glucose and modulating lipid metabolism and has been shown to attenuate myocardial ischemia-reperfusion (IR) injury in non-diabetic subjects. However, whether PT can protect against myocardial IR injury in diabetes is unknown. AMPK stimulation is indispensable in offering cardioprotection against myocardial IR injury in diabetes by limiting cardiac apoptosis. Thus, we hypothesized that PT may confer protection against myocardial IR injury in diabetes via AMPK activation...
April 18, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29689564/pulmonary-exposure-to-particulate-matter-pm2-5-affects-the-sensitivity-to-myocardial-ischemia-reperfusion-injury-through-farnesoid-x-receptor-induced-autophagy
#12
Fei Tong, Hua Zhang
BACKGROUND/AIMS: The purpose of this study was to investigate the effect of administering particulate matter (PM2.5) to the lungs on the sensitivity to myocardial ischemia/reperfusion injury (MI/RI) and the role of farnesoid-X-receptor (FXR)-induced autophagy in this process. METHODS: Male Sprague Dawley (SD) rats were subjected to 45 min of ischemia, and the lungs were exposed to 2.0 mg of PM2.5 in 0.3 mL of normal saline 5 min before reperfusion. After 24 h of reperfusion, the blood and myocardium were collected, and the myocardial infarct sizes, activities of serum creatine kinase (CK) and lactate dehydrogenase (LDH), and levels of serum high sensitivity C-reactive protein (hsCRP), interleukin-4 (IL-4), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), cardiac troponin T (cTnT), P-selectin and D-dimer were measured via biochemical analysis...
April 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29689531/genomic-and-transcriptomic-alterations-in-leishmania-donovani-lines-experimentally-resistant-to-antileishmanial-drugs
#13
Alberto Rastrojo, Raquel García-Hernández, Paola Vargas, Esther Camacho, Laura Corvo, Hideo Imamura, Jean-Claude Dujardin, Santiago Castanys, Begoña Aguado, Francisco Gamarro, Jose M Requena
Leishmaniasis is a serious medical issue in many countries around the World, but it remains largely neglected in terms of research investment for developing new control and treatment measures. No vaccines exist for human use, and the chemotherapeutic agents currently used are scanty. Furthermore, for some drugs, resistance and treatment failure are increasing to alarming levels. The aim of this work was to identify genomic and trancriptomic alterations associated with experimental resistance against the common drugs used against VL: trivalent antimony (SbIII , S line), amphotericin B (AmB, A line), miltefosine (MIL, M line) and paromomycin (PMM, P line)...
April 13, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29689378/in-utero-and-lactational-exposure-of-dehp-increases-the-susceptibility-of-prostate-carcinogenesis-in-male-offspring-through-psca-hypomethylation
#14
Bin Xia, Yong Wang, Xiu Wang, Jianhui Wu, Qi Song, Zuyue Sun, Yunhui Zhang
As an ubiquitous environmental endocrine disruptor, di(2-ethylhexyl) phthalate (DEHP) has been shown to interfere with the development of reproductive organs and induce pathological changes in prostate. Our previous finding showed that in utero and lactational (IUL) DEHP exposure could disrupt the balance of testosterone and estrogen and increase the susceptibility of prostate carcinogenesis. The purpose of this study is to investigate whether the early-life specific epigenetic modifications could mediate the effect of DEHP exposure on prostate carcinogenesis in rodents, for epigenetic modifications play important roles in regulating prostate carcinogenesis...
April 21, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29689346/b-type-natriuretic-peptide-attenuates-endoplasmic-reticulum-stress-in-h9c2-cardiomyocytes-underwent-hypoxia-reoxygenation-injury-under-high-glucose-high-fat-conditions
#15
Pan Chang, Mingyang Zhang, Xiaomeng Zhang, Guohua Li, Haiyan Hu, Juan Wu, Xihui Wang, Zihua Yang, Jing Zhang, Weiguo Chen, Minggang Ren, Xin Li, Miaozhang Zhu, Baoying Chen, Jun Yu
Exogenously administered B-type natriuretic peptide (BNP) has been shown to provide cardioprotection against various heart diseases. However, the underlying mechanisms remain elusive. This study explores whether BNP exerts its cardioprotection against hypoxia/reoxygenation (H/R) injury under high glucose/high fat (HG/HF) conditions in cardiac H9c2 cells and uncovers the underlying mechanisms. Our data revealed that BNP significantly increased the cell viability and decreased the release of lactate dehydrogenase (LDH) and creatine kinase (CK), with a maximal effect at the BNP concentration of 10-7  mol/L...
April 21, 2018: Peptides
https://www.readbyqxmd.com/read/29689337/gender-specific-desensitization-of-group-i-metabotropic-glutamate-receptors-after-maternal-l-glutamate-intake-during-lactation
#16
Antonio López-Zapata, David Agustín León-Navarro, María Crespo, Mairena Martín
In the present work we have studied the effect of maternal intake of l-Glutamate (l-Glu) (1 g/L) during lactation on group I mGluR transduction pathway in brain plasma membrane from 15 days-old neonates. Results obtained have shown that maternal l-glutamate intake did not significantly affect neither weights of pups nor negative geotaxis reflex, an index of neurobehavioral development, but increased l-Glu plasma level in both male and female neonates. In male neonates, maternal l-Glu intake evoked a loss of mGluR1 whereas no variation on mGluR5 was observed as revealed by Western-blotting assay...
April 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29689212/behavior-oxytocin-promotes-fearless-motherhood
#17
Lior Cohen, Mouna Maroun, Shlomo Wagner
In mammals, lactating mothers show reduced fear and anxiety. A new study reveals the way by which the lactation-inducing neuropeptide oxytocin attenuates social fear in lactating female mice by inhibiting activity in a single brain area.
April 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29689020/factors-that-influence-human-milk-feeding-at-hospital-discharge-for-preterm-infants-in-a-tertiary-neonatal-care-center-in-taiwan
#18
Chia-Ming Pai, Wai-Tim Jim, Hsiang-Yu Lin, Chyong-Hsin Hsu, Hsin-An Kao, Han-Yang Hung, Chun-Chih Peng, Jui-Hsing Chang
Human milk is considered optimal nutrition for newborn infants, especially preterm infants, and it can lessen morbidity in this population. Human milk feeding at hospital discharge may encourage breastfeeding at home. This study evaluated the incidence and predictive factors of human milk feeding of preterm infants at discharge. It included all preterm infants with gestational age of less than 37 weeks who were admitted to the Mackay Memorial Hospital in Taiwan from January to December 2010 who survived to discharge...
April 2018: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29689019/sustained-breastfeeding-and-related-factors-for-late-preterm-and-early-term-infants
#19
Joan Esper Kuhnly
The purpose of this pilot study was to determine the prevalence of sustained breastfeeding in late preterm and early term breastfeeding infants at 1 and 2 months of age and to identify the factors that were related to sustained breastfeeding. Subjects were identified through purposive sampling and completed the Breastfeeding Self-Efficacy Scale and data were collected on lactation support, hospital course details, and demographic factors. At 1 and 2 months of age, structured telephone interviews determined the current feeding status and postdischarge lactation support...
April 2018: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29689018/beyond-bfhi-the-spatz-10-step-and-breastfeeding-resource-nurse-model-to-improve-human-milk-and-breastfeeding-outcomes
#20
Diane L Spatz
A report released by the World Health Organization states that worldwide less than 10% of birth occur in hospitals certified through the Baby-Friendly Hospital Initiative. Furthermore, the Baby-Friendly Hospital Initiative's primary focus is on breastfeeding for healthy, mother-infant dyads. This article provides alternative models for implementing evidence-based care during maternal-infant separation so that mothers can achieve their personal breastfeeding goals. These include the Spatz 10-step model for human milk and breastfeeding in vulnerable infants and the Breastfeeding Resource Nurse model...
April 2018: Journal of Perinatal & Neonatal Nursing
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