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https://www.readbyqxmd.com/read/29458218/effects-of-curcuminoids-plus-piperine-on-glycemic-hepatic-and-inflammatory-biomarkers-in-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#1
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Luis E Simental-Mendía, Muhammed Majeed, Amirhossein Sahebkar
INTRODUCTION: Curcuminoids have been shown to reduce glycemia and related complications in diabetes. In the present study, we evaluated the impact of curcuminoids plus piperine administration on glycemic, hepatic and inflammatory biomarkers in type 2 diabetes (T2D) patients. METHODS: T2D patients aged 18-65 years were enrolled in a randomized double-blind placebo-controlled trial and randomly allocated to standard-of-care treatment and dietary advises plus either curcuminoids (daily dose of 500 mg/day co-administered with piperine 5 mg/day) or placebo for a period of 3 months...
February 19, 2018: Drug Research
https://www.readbyqxmd.com/read/29447046/oral-curcumin-supplementation-improves-fine-motor-function-in-the-middle-aged-rhesus-monkey
#2
Tara L Moore, Bethany G E Bowley, Penny L Shultz, Samantha M Calderazzo, Eli J Shobin, Ajay R Uprety, Douglas L Rosene, Mark B Moss
Aged individuals experience decreased fine motor function of the hand and digits, which could result, in part, from the chronic, systemic state of inflammation that occurs with aging. Recent research for treating age-related inflammation has focused on the effects of nutraceuticals that have anti-inflammatory properties. One particular dietary polyphenol, curcumin, the principal curcuminoid of the spice turmeric, has been shown to have significant anti-inflammatory effects and there is mounting evidence that curcumin may serve to reduce systemic inflammation...
February 15, 2018: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29426423/improvement-of-curcuminoid-bioaccessibility-from-turmeric-by-a-nanostructured-lipid-carrier-system
#3
Sung Jin Park, Coralia V Garcia, Gye Hwa Shin, Jun Tae Kim
Turmeric contains curcumin and its analogues, which show anticancer and antiinflammatory effects; however, curcuminoids are lipophilic and are poorly absorbed by the human body. Nanostructured lipid carriers for encapsulating whole turmeric powder were successfully produced by ultrasonication, and their physicochemical properties and stability in simulated gastric and intestinal media were evaluated. The turmeric nanostructured lipid carriers (TNLCs) exhibited a round shape, small diameter (282 ± 7.19 nm), adequate zeta potential (-22...
June 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29376494/antiarthritic-effect-of-polar-extract-of-curcuma-longa-on-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#4
Sasikumar Murugan, Bharathi Bethapudi, Divya Purusothaman, Prasanna Raja, Chandrasekaran Chinampudur Velusami
BACKGROUND: Curcuma longa Linn, "the golden spice" is a common spice used in southern Asia and Middle East countries. It has a history of ethnopharmacological use for its various functional activities like antiseptic, anti-inflammatory, antioxidant, antimicrobial, anticancer and so on. OBJECTIVE: To investigate the effects of polar extract of C. longa (PCL) against monosodium iodoacetate (MIA) induced osteoarthritis in rat and to compare with curcuminoids, which are contemporarily believed to be the only active phytochemicals of C...
January 26, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29369626/unusually-short-lived-solvent-dependent-excited-state-in-a-half-sandwich-ru-ii-complexe-induced-by-low-lying-3mc-states
#5
Kilian Rolf Anton Schneider, Philipp Traber, Christian Reichardt, Henning Weiss, Stephan Kupfer, Helmar Görls, Stefanie Gräfe, Wolfgang Weigand, Benjamin Dietzek
A ruthenium complex with a half-sandwich geometry ([(p-cymene)Ru(Cl)(curcuminoid)]) was synthesized, character-ized and investigated regarding its ultrafast photophysics. These photophysical investigations of the complex revealed a weak and short-lived emission from the initially populated 1MLCT state and solvent dependent photo-induced dynamics, where the secondarily populated 3MC state is stabilized by non-polar solvents. Overall the decay of the 3dd-MC state to the ground state is completed within ps. This short excited state lifetime is in stark contrast to the typically observed long-lived 3MLCT states with lifetimes of ns or µs in unstrained, octahedral ru-thenium complexes, but is in good agreement with the findings for distorted octahedral complexes...
January 25, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29368356/superior-anticancer-activity-is-demonstrated-by-total-extract-of-curcuma-longa-l-as-opposed-to-individual-curcuminoids-separated-by-centrifugal-partition-chromatography
#6
Wirginia Kukula-Koch, Aneta Grabarska, Jarogniew Łuszczki, Lidia Czernicka, Ewa Nowosadzka, Ewelina Gumbarewicz, Agata Jarząb, Gregoire Audo, Shakti Upadhyay, Kazimierz Głowniak, Andrzej Stepulak
Three curcuminoids: bisdemethoxycurcumin, demethoxycurcumin, and curcumin from turmeric were successfully separated by a high capacity solvent system composed of heptane: chloroform: methanol: water mixture (5: 6: 3: 2 v/v/v/v) tailored for centrifugal partition chromatographs at K-values of 0.504, 1.057, 1.644, respectively. These three ferulic acid derivatives obtained at a purity rate exceeding 95% were analysed by an HPLC-MS spectrometer. Turmeric extract inhibited the proliferation/viability of A549 human lung cancer, HT29 colon cancer, and T98G glioblastoma cell lines in (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay (MTT)...
January 24, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29361519/curcumin-and-derivatives-function-through-protein-phosphatase-2a-and-presenilin-orthologues-in-dictyostelium-discoideum
#7
Marco Cocorocchio, Amy J Baldwin, Balint Stewart, Lou Kim, Adrian J Harwood, Christopher R L Thompson, Paul L R Andrews, Robin S B Williams
Natural compounds often have complex molecular structures and unknown molecular targets. These characteristics make them difficult to analyse using a classical pharmacological approach. Curcumin, the main curcuminoid of turmeric, is a complex molecule possessing wide-ranging biological activities, cellular mechanisms and roles in potential therapeutic treatment including Alzheimer's disease and cancer. Here, we investigate the physiological effects and molecular targets of curcumin in Dictyostelium discoideum We show curcumin causes acute effects on cell behaviour, reduces cell growth, and slows multicellular development...
December 28, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29333037/curcumin-and-natural-derivatives-inhibit-ebola-viral-proteins-an-in-silico-approach
#8
Shruti Baikerikar
Background: Ebola viral disease is a severe and mostly fatal disease in humans caused by Ebola virus. This virus belongs to family Filoviridae and is a single-stranded negative-sense virus. There is no single treatment for this disease which puts forth the need to identify new therapy to control and treat this fatal condition. Curcumin, one of the bioactives of turmeric, has proven antiviral property. Objective: The current study evaluates the inhibitory activity of curcumin, bisdemethoxycurcumin, demethoxycurcumin, and tetrahydrocurcumin against Zaire Ebola viral proteins (VPs)...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29331487/curecuma-cationic-curcuminoids-with-improved-properties-and-enhanced-antimicrobial-photodynamic-activity
#9
Andreas Spaeth, Andre Graeler, Tim Maisch, Kristjan Plaetzer
The naturally occurring photosensitizer curcumin has excellent biocompatibility, but its antimicrobial photodynamic efficacy is limited by (i) weak adherence to Gram(-) cell walls, (ii) low (photo-)stability and (iii) limited solubility in water. In this study novel curcuminoids bearing cationic substituents were prepared by different synthetic routes. The derivatives exhibit excellent water solubility, improved photostability and low aggregation. All novel curcuminoids showed antibacterial photodynamic effects (>3 log10 reduction of CFU) against Escherichia coli and Staphylococcus aureus upon blue light illumination...
October 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29316908/efficacy-and-safety-of-curcumin-and-its-combination-with-boswellic-acid-in-osteoarthritis-a-comparative-randomized-double-blind-placebo-controlled-study
#10
Armine Haroyan, Vahan Mukuchyan, Nana Mkrtchyan, Naira Minasyan, Srbuhi Gasparyan, Aida Sargsyan, Mikael Narimanyan, Areg Hovhannisyan
BACKGROUND: The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA). METHODS: The effects of CuraMed® 500-mg capsules (333 mg curcuminoids) and Curamin® 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial...
January 9, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29303982/curcumin-analog-dk1-induces-apoptosis-in-human-osteosarcoma-cells-in-vitro-through-mitochondria-dependent-signaling-pathway
#11
Muhammad Nazirul Mubin Aziz, Yazmin Hussin, Nurul Fattin Che Rahim, Noraini Nordin, Nurul Elyani Mohamad, Swee Keong Yeap, Chean Yeah Yong, Mas Jaffri Masarudin, Yoke Kqueen Cheah, Nadiah Abu, Muhammad Nadeem Akhtar, Noorjahan Banu Alitheen
Osteosarcoma is one of the primary malignant bone tumors that confer low survival rates for patients even with intensive regime treatments. Therefore, discovery of novel anti-osteosarcoma drugs derived from natural products that are not harmful to the normal cells remains crucial. Curcumin is one of the natural substances that have been extensively studied due to its anti-cancer properties and is pharmacologically safe considering its ubiquitous consumption for centuries. However, curcumin suffers from a poor circulating bioavailability, which has led to the development of a chemically synthesized curcuminoid analog, namely (Z)-3-hydroxy-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (DK1)...
January 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29299989/curcuminoids-plus-piperine-modulate-adipokines-in-type-2-diabetes-mellitus
#12
Amirhossein Sahebkar, Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Stephen L Atkin, Muhammed Majeed
OBJECTIVE: Curcumin is a naturally occurring polyphenol derived from tumeric that has been reported to have anti-inflammatory properties with effects on adipokine and ghrelin levels. Adiponectin, leptin and ghrelin modulate energy homeostasis but each have modulatory effects on inflammatory cytokines and the immune system. Therefore this analysis was performed to investigate the effect of curcumin on adiponectin, leptin and ghrelin. METHODS: A double blind randomised control trial comparing curcumin 1000mg with 10mg of piperine daily to placebo over a 12 week period...
January 3, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29289889/synthesis-characterization-and-ros-mediated-antitumor-effects-of-palladium-ii-complexes-of-curcuminoids
#13
Yanci Li, Zhenyu Gu, Can Zhang, Shenghui Li, Liang Zhang, Guoqiang Zhou, Shuxiang Wang, Jinchao Zhang
Based on the synthesis of curcumin and its derivatives from aromatic aldehydes, a novel series of palladium(II) complexes with curcumin (or its derivatives) and 2,2'-bipyridine have been synthesized through a directed self-assembly approach that involves spontaneous deprotonation of the curcuminoid ligands in H2O/acetone solution. These complexes have been characterized by 1H (13C) NMR, HRMS and elemental analysis. Crystal structure of 3h has been determined by X-ray diffraction analysis. Their cytotoxicity was tested by MTT...
December 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29287782/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic-neurotransmission-and-consolidates-memory-in-male-rats
#14
Laraib Liaquat, Zehra Batool, Sadia Sadir, Sahar Rafiq, SidrahShahzad, Tahira Perveen, Saida Haider
AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress...
December 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/29243674/turmeric-a-condiment-cosmetic-and-cure
#15
REVIEW
Hima Gopinath, Kaliaperumal Karthikeyan
Turmeric (Curcuma longa L.) is an integral part of Asian culture and cuisine. It has been used in traditional medicine since centuries. A myriad of health benefits have been attributed to it. Curcumin, the most biologically active curcuminoid in turmeric, is being investigated in pre-clinical and clinical trials for its role in disease prevention and cure. It has antioxidant, anti-inflammatory, antineoplastic, anti-proliferative and antimicrobial effects. We review the chemistry of this plant, its cultural relevance in Indian skin care, and its uses in dermatology...
January 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29229242/synthesis-characterisation-and-biomedical-applications-of-curcumin-conjugated-chitosan-microspheres
#16
T S Saranya, V K Rajan, Raja Biswas, R Jayakumar, S Sathianarayanan
Curcumin is a diaryl heptanoid of curcuminoids class obtained from Curcuma longa. It possesses various biological activities like anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Chitosan is a biocompatible, biodegradable and non-toxic natural polymer which enhances the adhesive property of the skin. Chemical conjugation will leads to sustained release action and to enhance the bioavailability. This study aims to synthesis and characterize biocompatible curcumin conjugated chitosan microspheres for bio-medical applications...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29226928/evaluation-of-the-in-vivo-acute-antiinflammatory-response-of-curcumin-loaded-nanoparticles
#17
Mariana de Almeida, Bruno Ambrósio da Rocha, Cristhian Rafael Lopes Francisco, Cristiane Grella Miranda, Priscila Dayane de Freitas Santos, Pedro Henrique Hermes de Araújo, Claudia Sayer, Fernanda Vitória Leimann, Odinei Hess Gonçalves, Ciomar Aparecida Bersani-Amado
Curcumin is the main curcuminoid found in turmeric rhizomes and is a strong candidate to formulate foodstuff with specific properties. Among various bioactive properties of curcumin, its antiinflammatory activity is remarkable; on the other hand, its low water solubility leads to low absorption. Thus, new formulations need to be developed to improve its efficacy, and encapsulation is a promising alternative strategy in this regard. The objective of the present study was to obtain curcumin-loaded polyvinylpyrrolidone (PVP) nanoparticles and evaluate their acute in vivo antiinflammatory activity...
December 11, 2017: Food & Function
https://www.readbyqxmd.com/read/29225191/the-comprehensive-electrophysiological-study-of-curcuminoids-on-delayed-rectifier-k-currents-in-insulin-secreting-cells
#18
Ping-Chung Kuo, Chia-Jung Yang, Yu-Chi Lee, Pei-Chun Chen, Yen-Chin Liu, Sheng-Nan Wu
Curcumin (CUR) has been demonstrated to induce insulin release from pancreatic β-cells; however, how curcuminoids (including demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC)) exert any possible effects on membrane ion currents inherently in insulin-secreting cells remains largely unclear. The effects of CUR and other structurally similar curcuminoids on ion currents in rat insulin-secreting (INS-1) insulinoma cells were therefore investigated in this study. The effects of these compounds on ionic currents and membrane potential were studied by patch-clamp technique...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29209088/inhibitory-effects-of-curcumin-and-cyclocurcumin-in-1-methyl-4-phenylpyridinium-mpp-induced-neurotoxicity-in-differentiated-pc12-cells
#19
Sandeep Chakraborty, Artashes Karmenyan, Jin-Wu Tsai, Arthur Chiou
Development and progression of neurodegenerative diseases like Parkinson's disease (PD) involve multiple pathways. Thus, effective therapeutic treatments should intervene to address all these pathways simultaneously for greater success. Most of the current pharmacotherapeutic approaches just supplement striatal dopamine. Hence, natural extracts of plants with therapeutic potential have been explored. Curcuminoids belong to one such group of polyphenol which show immense therapeutic effects. Here, we have used intracellular reactive oxygen species (ROS) measurement, and two-photon fluorescence lifetime imaging microscopy (2P-FLIM) of cellular autofluorescent co-enzyme reduced nicotinamide adenine dinucleotide (NADH) to study the inhibitory effects of curcumin and cyclocurcumin in alleviating PD like neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in neuronal growth factor (NGF) induced differentiated PC12 cells...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29185808/lipid-modifying-activity-of-curcuminoids-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Luis E Simental-Mendía, Matteo Pirro, Antonio M Gotto, Maciej Banach, Stephen L Atkin, Muhammed Majeed, Amirhossein Sahebkar
OBJECTIVE: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. METHODS: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method...
November 29, 2017: Critical Reviews in Food Science and Nutrition
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