keyword
MENU ▼
Read by QxMD icon Read
search

Curcuminoids

keyword
https://www.readbyqxmd.com/read/29209088/inhibitory-effects-of-curcumin-and-cyclocurcumin-in-1-methyl-4-phenylpyridinium-mpp-induced-neurotoxicity-in-differentiated-pc12-cells
#1
Sandeep Chakraborty, Artashes Karmenyan, Jin-Wu Tsai, Arthur Chiou
Development and progression of neurodegenerative diseases like Parkinson's disease (PD) involve multiple pathways. Thus, effective therapeutic treatments should intervene to address all these pathways simultaneously for greater success. Most of the current pharmacotherapeutic approaches just supplement striatal dopamine. Hence, natural extracts of plants with therapeutic potential have been explored. Curcuminoids belong to one such group of polyphenol which show immense therapeutic effects. Here, we have used intracellular reactive oxygen species (ROS) measurement, and two-photon fluorescence lifetime imaging microscopy (2P-FLIM) of cellular autofluorescent co-enzyme reduced nicotinamide adenine dinucleotide (NADH) to study the inhibitory effects of curcumin and cyclocurcumin in alleviating PD like neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in neuronal growth factor (NGF) induced differentiated PC12 cells...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29185808/lipid-modifying-activity-of-curcuminoids-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
Luis E Simental-Mendía, Matteo Pirro, Antonio M Gotto, Maciej Banach, Stephen L Atkin, Muhammed Majeed, Amirhossein Sahebkar
OBJECTIVE: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. METHODS: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method...
November 29, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29149547/engineering-escherichia-coli-co-cultures-for-production-of-curcuminoids-from-glucose
#3
Zhen Fang, J Andrew Jones, Jingwen Zhou, Mattheos A G Koffas
Curcuminoids have attracted increasing attention because of the antioxidant, anticancer, and antitumor activities while their production is limited because of its main source, turmeric plant, demonstrates extensive seasonal variation. In this study, we constructed Escherichia coli co-culture system for the rapid production of curcuminoids from glucose. Firstly, the overexpression of curcuminoid synthase and four different strategies related to increasing the intracellular malonyl-CoA pool were conducted in engineered E...
November 17, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29149546/the-photophysical-and-photoacoustic-properties-of-quadrupolar-borondifluoride-curcuminoid-dyes
#4
Stephanie Bellinger, Maryam Hatamimoslehabadi, Seema Bag, Farha Mithila, Jeffrey La, Mathieu Frennete, Samir Laoui, David Szalda, Chandra Yelleswarapu, Jonathan Rochford
The synthesis and characterization of a series of donor-π-acceptor-π-donor (D-A-D) curcuminoid molecules are here presented incorporating π-extended aryl and electron-donating amino terminal functionalization. Computational evaluation shows these molecules possess quadrupolar character with the lowest energy transitions displaying high molar extinction coefficients with broad tunability through manipulation of terminal donating groups. Consistent with their quadrupolar nature, these molecules show varying degrees of solvatochromic behavior in both their absorption and emission spectra which has been analyzed by Lippert-Mataga and Kamlet-Taft analysis...
November 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29147872/fluidized-bed-hot-melt-granulation-as-a-tool-to-improve-curcuminoid-solubility
#5
Cristiane C C Teixeira, Elias de Paiva Junior, Luis Alexandre Pedro de Freitas
Curcumin is the main bioactive component of Curcuma longa L. and has recently aroused growing interest from the scientific community. Unfortunately, the medicinal properties attributed to curcuminoids are impaired by their low oral bioavailability or low solubility in aqueous solutions. Many strategies have been studied to improve curcumin solubility; however, the preparation of granules using hydrophilic materials has never been attempted. The aim of this work was to develop curcumin granules by fluidized bed hot-melt granulation using the hydrophilic carrier Gelucire® 50:13...
November 16, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29146529/inhibitory-effect-of-the-extract-of-rhizome-of-curcuma-longa-l-in-gelatinase-activity-and-its-effect-on-human-skin
#6
Keiko Muta, Shinji Inomata, Tadao Fukuhara, Junko Nomura, Toshio Nishiyama, Yoh-Ichi Tagawa, Satoshi Amano
Exposure to UV radiation to human skin up-regulates the synthesis of matrix metalloproteinase (MMP) family. Gelatinases are member of MMPs which have been suggested to play an important role in photoaging such as wrinkle formation. To inhibit gelatinase activity is regarded to be very important to keep healthy skin and to protect wrinkle formation. On the other hand, anti-photoaging agents are expected to be derived from natural resources, especially plants. Plant extracts having gelatinase-inhibitory effect that might be used as safe anti-photoaging ingredient were widely screened...
November 13, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29138806/effect-of-bis-hydroxymethyl-alkanoate-curcuminoid-derivative-mth-3-on-cell-cycle-arrest-apoptotic-and-autophagic-pathway-in-triple-negative-breast-adenocarcinoma-mda-mb-231-cells-an-in-vitro-study
#7
Ling-Chu Chang, Min-Tsang Hsieh, Jai-Sing Yang, Chi-Cheng Lu, Fuu-Jen Tsai, Je-Wei Tsao, Yu-Jen Chiu, Sheng-Chu Kuo, Kuo-Hsiung Lee
Curcumin has been shown to exert potential antitumor activity in vitro and in vivo involved in multiple signaling pathways. However, the application of curcumin is still limited because of its poor hydrophilicity and low bio-availability. In the present study, we investigated the therapeutic effects of a novel and water soluble bis(hydroxymethyl) alkanoate curcuminoid derivative, MTH-3, on human breast adenocarcinoma MDA-MB-231 cells. This study investigated the effect of MTH-3 on cell viability, cell cycle and induction of autophagy and apoptosis in MDA-MB-231 cells...
November 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29115589/anti-neuroinflammatory-effect-of-curcumin-on-pam3csk4-stimulated-microglial-cells
#8
Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang
Curcumin is the main curcuminoid present in Curcuma longa and it has been previously reported to exhibit a wide range of pharmacological activities. In the present study, the inhibitory effects of curcumin on the inflammatory mediators released by Pam3CSK4-stimulated BV-2 microglial cells were investigated. The production of pro-inflammatory mediators and cytokines, including tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2), were measured by enzyme‑linked immunosorbent assay (ELISA). The expression of inflammatory genes, including inducible nitric oxide synthase and cyclooxygenase-2, were further investigated using reverse transcription-quantitative polymerase chain reaction...
January 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29114330/curcuminoid-bf2-complexes-synthesis-fluorescence-and-optimization-of-bf2-group-cleavage
#9
Henning Weiss, Jeannine Reichel, Helmar Görls, Kilian Rolf Anton Schneider, Mathias Micheel, Michael Pröhl, Michael Gottschaldt, Benjamin Dietzek, Wolfgang Weigand
Eight difluoroboron complexes of curcumin derivatives carrying alkyne groups containing substituents have been synthesized following an optimised reaction pathway. The complexes were received in yields up to 98% and high purities. Their properties as fluorescent dyes have been investigated. Furthermore, a strategy for the hydrolysis of the BF2 group has been established using aqueous methanol and sodium hydroxide or triethylamine.
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29102796/extraction-of-curcuminoids-by-using-ethyl-lactate-and-its-optimisation-by-response-surface-methodology
#10
Angelo Antonio D'Archivio, Maria Anna Maggi, Fabrizio Ruggieri
Response surface methodology (RSM) was applied to optimise the extraction of curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) from turmeric using ethyl lactate (EL), ethanol and water under mild conditions (magnetic stirring at room temperature). An augmented simplex-centroid mixture design was used to monitor the dependence of the extraction efficiency from the proportions of the three solvents in the extraction medium. HPLC was used to establish the content of curcuminoids in turmeric and in the extracts...
November 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29036814/curcumin-ameliorates-neuroinflammation-neurodegeneration-and-memory-deficits-in-p25-transgenic-mouse-model-that-bears-hallmarks-of-alzheimer-s-disease
#11
Jeyapriya Raja Sundaram, Charlene Priscilla Poore, Noor Hazim Bin Sulaimee, Tej Pareek, Wei Fun Cheong, Markus R Wenk, Harish C Pant, Sally A Frautschy, Chian-Ming Low, Sashi Kesavapany
Several studies have indicated that neuroinflammation is indeed associated with neurodegenerative disease pathology. However, failures of recent clinical trials of anti-inflammatory agents in neurodegenerative disorders have emphasized the need to better understand the complexity of the neuroinflammatory process in order to unravel its link with neurodegeneration. Deregulation of Cyclin-dependent kinase 5 (Cdk5) activity by production of its hyperactivator p25 is involved in the formation of tau and amyloid pathology reminiscent of Alzheimer's disease (AD)...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29029547/nanoformulations-of-curcumin-an-emerging-paradigm-for-improved-remedial-application
#12
REVIEW
Meeta Gera, Neelesh Sharma, Mrinmoy Ghosh, Do Luong Huynh, Sung Jin Lee, Taesun Min, Taeho Kwon, Dong Kee Jeong
Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant Curcuma longa (L.) is universally acknowledged as "Wonder drug of life". It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potential, the poor aqueous solubility and consequently, minimal systemic bioavailability with rapid degradation are some of the major factors which restrict the utilization of curcumin at medical perspective...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027274/comparative-oral-absorption-of-curcumin-in-a-natural-turmeric-matrix-with-two-other-curcumin-formulations-an-open-label-parallel-arm-study
#13
Sreeraj Gopi, Joby Jacob, Karthik Varma, Shintu Jude, Augustine Amalraj, C A Arundhathy, Robin George, T R Sreeraj, C Divya, Ajaikumar B Kunnumakkara, Sidney J Stohs
Curcuminoids are the major bioactive molecules in turmeric, and poor bioavailability deters them from being the major components of many health and wellness applications. This study was conducted to assess the bioavailability of a completely natural turmeric matrix formulation (CNTMF) and compare its bioavailability with two other commercially available formulations, namely, curcumin with volatile oil (volatile oil formulation) and curcumin with phospholipids and cellulose (phospholipid formulation) in healthy human adult male subjects (15 each group) under fasting conditions...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29023392/disposition-metabolism-and-histone-deacetylase-and-acetyltransferase-inhibition-activity-of-tetrahydrocurcumin-and-other-curcuminoids
#14
Júlia T Novaes, Ryan Lillico, Casey L Sayre, Kalyanam Nagabushnam, Muhammed Majeed, Yufei Chen, Emmanuel A Ho, Ana Luísa de P Oliveira, Stephanie E Martinez, Samaa Alrushaid, Neal M Davies, Ted M Lakowski
Tetrahydrocurcumin (THC), curcumin and calebin-A are curcuminoids found in turmeric (Curcuma longa). Curcuminoids have been established to have a variety of pharmacological activities and are used as natural health supplements. The purpose of this study was to identify the metabolism, excretion, antioxidant, anti-inflammatory and anticancer properties of these curcuminoids and to determine disposition of THC in rats after oral administration. We developed a UHPLC-MS/MS assay for THC in rat serum and urine. THC shows multiple redistribution phases with corresponding increases in urinary excretion rate...
October 12, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28991167/achiral-mannich-base-curcumin-analogs-induce-unfolded-protein-response-and-mitochondrial-membrane-depolarization-in-panc-1-cells
#15
Gábor J Szebeni, Árpád Balázs, Ildikó Madarász, Gábor Pócz, Ferhan Ayaydin, Iván Kanizsai, Roberta Fajka-Boja, Róbert Alföldi, László Hackler, László G Puskás
Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of curcuminoids has been tested on human non-small-cell lung carcinoma (A549), hepatocellular carcinoma (HepG2) and pancreatic cancer cell line (PANC-1). Based on the highest anti-proliferative activity nine drug candidates were further tested and proved to cause phosphatidylserine exposure as an early sign of apoptosis. Curcumin analogs with the highest apoptotic activity were selected for mechanistic studies in the most sensitive PANC-1 cells...
October 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28975371/bithiophenic-maldi-matrices-as-valuable-leads-for-the-selective-detection-of-alkaloids
#16
Ali Jaber, Denis Seraphin, David Guilet, Junichi Osuga, Edmond Cheble, Ghassan Ibrahim, Pascal Richomme, Andreas Schinkovitz
Alkaloids represent a group of biologically most interesting compounds commonly used in modern medicines but also known for exhibiting severe toxic effects. Therefore, the detection of alkaloids is an important issue in quality control of plants, dietary supplements, and herbal pharmaceutical and mostly facilitated by methods such as GC or LC-MS. However, benefitting from the development of selective matrices as well as requiring very little sample preparation, MALDI-MS may also provide a valuable supplement to these standard analytical methods...
October 3, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28962868/chemopreventive-effects-of-fitoprot-against-5-fluorouracil-induced-toxicity-in-hacat-cells
#17
Edvande Xavier Dos Santos Filho, Artur Christian Garcia da Silva, Renato Ivan de Ávila, Aline Carvalho Batista, Ricardo Neves Marreto, Eliana Martins Lima, Cecília Maria Alves de Oliveira, Elismauro Francisco Mendonça, Marize Campos Valadares
AIMS: This study evaluated the mechanisms involved in the chemopreventive effects of a mucoadhesive formulation (FITOPROT), containing curcuminoids from Curcuma longa L. (Zingiberaceae) and Bidens pilosa L. (Asteraceae) extract, against 5-FU-induced cellular toxicity using an in vitro oral mucositis model. MAIN METHODS: Effects of FITOPROT on 5-FU-induced cytotoxicity in HaCaT and SSC-4 cells were evaluated by MTT assay. For mechanistic analyzes, HaCaT cells were first pretreated with FITOPROT (0...
September 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/28951052/identification-and-characterization-of-curcuminoids-in-turmeric-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry
#18
Shuailong Jia, Zhifeng Du, Chengwu Song, Shuna Jin, Yang Zhang, Yulin Feng, Chaomei Xiong, Hongliang Jiang
A three-step strategy was developed for systematic characterization of curcuminoids in turmeric. Based on UHPLC-QTOF-MS/MS analysis, 89 curcuminoids including 16 novel ones were identified in the turmeric samples using this approach. During the identification process, false positive results were excluded by combining the positive and negative ESI-MS/MS analyses. Moreover, the characterization of the keto and enol forms of type A, B and C curcuminoids was first discussed and they were clearly distinguished using negative ESI-MS/MS method with UV spectra analyses...
September 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28928074/curcumin-or-combined-curcuminoids-are-effective-in-lowering-the-fasting-blood-glucose-concentrations-of-individuals-with-dysglycemia-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Ingrid Sofia Vieira de Meloa, Aldenir Feitosa Dos Santosb, Nassib Bezerra Buenoc
Curcuminoids have received considerable attention as therapeutical adjuvants in the treatment of dysglycemia. The purpose of this meta-analysis was to evaluate whether the supplementation of turmeric extract, curcuminoids and/or isolated curcumin is more effective than placebo in decreasing fasting blood glucose (FBG) in adults. MEDLINE, CENTRAL, ScienceDirect and gray literature databases were searched. Randomized controlled trials with the following criteria were included: (1) studied individuals older than 18 years, supplemented with curcumin, curcuminoids and/or turmeric extract (2) had a follow-up ≥4 weeks (3) used a placebo group...
September 16, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28903060/effects-of-curcumin-and-curcumin-analogues-on-trp-channels
#20
REVIEW
Marianna Nalli, Giorgio Ortar, Aniello Schiano Moriello, Vincenzo Di Marzo, Luciano De Petrocellis
A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Twenty of them acted as good modulators of TRPA1 channels. None was able to significantly activate TRPM8 channels, while curcumin itself and six curcuminoids belonging to the 1,3-dicarbonyl and acyclic series behaved as 'true' antagonists with IC50 values<5μM. Only few curcuminoids were able to modulate TRPV1 channels with EC50 and IC50 values ranging from 3.4 and 6.0μM.
October 2017: Fitoterapia
keyword
keyword
62714
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"