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Curcuminoids

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https://www.readbyqxmd.com/read/29036814/curcumin-ameliorates-neuroinflammation-neurodegeneration-and-memory-deficits-in-p25-transgenic-mouse-model-that-bears-hallmarks-of-alzheimer-s-disease
#1
Jeyapriya Raja Sundaram, Charlene Priscilla Poore, Noor Hazim Bin Sulaimee, Tej Pareek, Wei Fun Cheong, Markus R Wenk, Harish C Pant, Sally A Frautschy, Chian-Ming Low, Sashi Kesavapany
Several studies have indicated that neuroinflammation is indeed associated with neurodegenerative disease pathology. However, failures of recent clinical trials of anti-inflammatory agents in neurodegenerative disorders have emphasized the need to better understand the complexity of the neuroinflammatory process in order to unravel its link with neurodegeneration. Deregulation of Cyclin-dependent kinase 5 (Cdk5) activity by production of its hyperactivator p25 is involved in the formation of tau and amyloid pathology reminiscent of Alzheimer's disease (AD)...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29029547/nanoformulations-of-curcumin-an-emerging-paradigm-for-improved-remedial-application
#2
REVIEW
Meeta Gera, Neelesh Sharma, Mrinmoy Ghosh, Do Luong Huynh, Sung Jin Lee, Taesun Min, Taeho Kwon, Dong Kee Jeong
Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant Curcuma longa (L.) is universally acknowledged as "Wonder drug of life". It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potential, the poor aqueous solubility and consequently, minimal systemic bioavailability with rapid degradation are some of the major factors which restrict the utilization of curcumin at medical perspective...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027274/comparative-oral-absorption-of-curcumin-in-a-natural-turmeric-matrix-with-two-other-curcumin-formulations-an-open-label-parallel-arm-study
#3
Sreeraj Gopi, Joby Jacob, Karthik Varma, Shintu Jude, Augustine Amalraj, C A Arundhathy, Robin George, T R Sreeraj, C Divya, Ajaikumar B Kunnumakkara, Sidney J Stohs
Curcuminoids are the major bioactive molecules in turmeric, and poor bioavailability deters them from being the major components of many health and wellness applications. This study was conducted to assess the bioavailability of a completely natural turmeric matrix formulation (CNTMF) and compare its bioavailability with two other commercially available formulations, namely, curcumin with volatile oil (volatile oil formulation) and curcumin with phospholipids and cellulose (phospholipid formulation) in healthy human adult male subjects (15 each group) under fasting conditions...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29023392/disposition-metabolism-and-histone-deacetylase-and-acetyltransferase-inhibition-activity-of-tetrahydrocurcumin-and-other-curcuminoids
#4
Júlia T Novaes, Ryan Lillico, Casey L Sayre, Kalyanam Nagabushnam, Muhammed Majeed, Yufei Chen, Emmanuel A Ho, Ana Luísa de P Oliveira, Stephanie E Martinez, Samaa Alrushaid, Neal M Davies, Ted M Lakowski
Tetrahydrocurcumin (THC), curcumin and calebin-A are curcuminoids found in turmeric (Curcuma longa). Curcuminoids have been established to have a variety of pharmacological activities and are used as natural health supplements. The purpose of this study was to identify the metabolism, excretion, antioxidant, anti-inflammatory and anticancer properties of these curcuminoids and to determine disposition of THC in rats after oral administration. We developed a UHPLC-MS/MS assay for THC in rat serum and urine. THC shows multiple redistribution phases with corresponding increases in urinary excretion rate...
October 12, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28991167/achiral-mannich-base-curcumin-analogs-induce-unfolded-protein-response-and-mitochondrial-membrane-depolarization-in-panc-1-cells
#5
Gábor J Szebeni, Árpád Balázs, Ildikó Madarász, Gábor Pócz, Ferhan Ayaydin, Iván Kanizsai, Roberta Fajka-Boja, Róbert Alföldi, László Hackler, László G Puskás
Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of curcuminoids has been tested on human non-small-cell lung carcinoma (A549), hepatocellular carcinoma (HepG2) and pancreatic cancer cell line (PANC-1). Based on the highest anti-proliferative activity nine drug candidates were further tested and proved to cause phosphatidylserine exposure as an early sign of apoptosis. Curcumin analogs with the highest apoptotic activity were selected for mechanistic studies in the most sensitive PANC-1 cells...
October 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28975371/bithiophenic-maldi-matrices-as-valuable-leads-for-the-selective-detection-of-alkaloids
#6
Ali Jaber, Denis Seraphin, David Guilet, Junichi Osuga, Edmond Cheble, Ghassan Ibrahim, Pascal Richomme, Andreas Schinkovitz
Alkaloids represent a group of biologically most interesting compounds commonly used in modern medicines but also known for exhibiting severe toxic effects. Therefore, the detection of alkaloids is an important issue in quality control of plants, dietary supplements, and herbal pharmaceutical and mostly facilitated by methods such as GC or LC-MS. However, benefitting from the development of selective matrices as well as requiring very little sample preparation, MALDI-MS may also provide a valuable supplement to these standard analytical methods...
October 3, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28962868/chemopreventive-effects-of-fitoprot-against-5-fluorouracil-induced-toxicity-in-hacat-cells
#7
Edvande Xavier Dos Santos Filho, Artur Christian Garcia da Silva, Renato Ivan de Ávila, Aline Carvalho Batista, Ricardo Neves Marreto, Eliana Martins Lima, Cecília Maria Alves de Oliveira, Elismauro Francisco Mendonça, Marize Campos Valadares
AIMS: This study evaluated the mechanisms involved in the chemopreventive effects of a mucoadhesive formulation (FITOPROT), containing curcuminoids from Curcuma longa L. (Zingiberaceae) and Bidens pilosa L. (Asteraceae) extract, against 5-FU-induced cellular toxicity using an in vitro oral mucositis model. MAIN METHODS: Effects of FITOPROT on 5-FU-induced cytotoxicity in HaCaT and SSC-4 cells were evaluated by MTT assay. For mechanistic analyzes, HaCaT cells were first pretreated with FITOPROT (0...
September 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/28951052/identification-and-characterization-of-curcuminoids-in-turmeric-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry
#8
Shuailong Jia, Zhifeng Du, Chengwu Song, Shuna Jin, Yang Zhang, Yulin Feng, Chaomei Xiong, Hongliang Jiang
A three-step strategy was developed for systematic characterization of curcuminoids in turmeric. Based on UHPLC-QTOF-MS/MS analysis, 89 curcuminoids including 16 novel ones were identified in the turmeric samples using this approach. During the identification process, false positive results were excluded by combining the positive and negative ESI-MS/MS analyses. Moreover, the characterization of the keto and enol forms of type A, B and C curcuminoids was first discussed and they were clearly distinguished using negative ESI-MS/MS method with UV spectra analyses...
September 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28928074/curcumin-or-combined-curcuminoids-are-effective-in-lowering-the-fasting-blood-glucose-concentrations-of-individuals-with-dysglycemia-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Ingrid Sofia Vieira de Meloa, Aldenir Feitosa Dos Santosb, Nassib Bezerra Buenoc
Curcuminoids have received considerable attention as therapeutical adjuvants in the treatment of dysglycemia. The purpose of this meta-analysis was to evaluate whether the supplementation of turmeric extract, curcuminoids and/or isolated curcumin is more effective than placebo in decreasing fasting blood glucose (FBG) in adults. MEDLINE, CENTRAL, ScienceDirect and gray literature databases were searched. Randomized controlled trials with the following criteria were included: (1) studied individuals older than 18 years, supplemented with curcumin, curcuminoids and/or turmeric extract (2) had a follow-up ≥4 weeks (3) used a placebo group...
September 16, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28903060/effects-of-curcumin-and-curcumin-analogues-on-trp-channels
#10
Marianna Nalli, Giorgio Ortar, Aniello Schiano Moriello, Vincenzo Di Marzo, Luciano De Petrocellis
A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Twenty of them acted as good modulators of TRPA1 channels. None was able to significantly activate TRPM8 channels, while curcumin itself and six curcuminoids belonging to the 1,3-dicarbonyl and acyclic series behaved as 'true' antagonists with IC50 values<5μM. Only few curcuminoids were able to modulate TRPV1 channels with EC50 and IC50 values ranging from 3.4 and 6.0μM.
October 2017: Fitoterapia
https://www.readbyqxmd.com/read/28884496/potential-role-of-curcumin-against-biofilm-producing-organisms-on-the-skin-a-review
#11
REVIEW
Alexandra R Vaughn, Kelly N Haas, Waqas Burney, Erich Andersen, Ashley K Clark, Robert Crawford, Raja K Sivamani
Turmeric root (Curcuma longa) is predominantly used as a spice, but has also long been known to possess antimicrobial, analgesic, antiinflammatory, and anticancer properties. One predominant group of active compounds in turmeric are curcuminoids, namely bright yellow-pigmented curcumin. While modern science has yet to fully investigate the therapeutic claims of turmeric and its derivatives, results have proven promising in decreasing pain and inflammation in arthritis, improving insulin sensitivity in diabetes, and even curing a variety of infections...
September 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28881286/synthesis-and-evaluation-of-asymmetric-curcuminoid-analogs-as-potential-anticancer-agents-that-downregulate-nf-%C3%AE%C2%BAb-activation-and-enhance-the-sensitivity-of-gastric-cancer-cell-lines-to-irinotecan-chemotherapy
#12
Peihong Qiu, Shanshan Zhang, Yangyang Zhou, Min Zhu, Yanting Kang, Dahui Chen, Jiabing Wang, Peng Zhou, Wulan Li, Qing Xu, Rong Jin, Jianzhang Wu, Guang Liang
NF-κB is a critical target for cancer treatment due to its central role in facilitating cancer progression and desensitizing cancer cells to chemotherapeutic drugs. In this study, a series of chemically modified asymmetric curcuminoid analogs named S01-S15 were synthesized and evaluated for NF-κB inhibitory activity in gastric cancer cell lines. Cell growth inhibition assays revealed that most of these analogs effectively inhibited the growth of BGC-823, SGC-7901, and MFC cells. S06 was selected for further research...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28880413/curcuminoids-lower-plasma-leptin-concentrations-a-meta-analysis
#13
Stephen L Atkin, Niki Katsiki, Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar
Curcumin is a naturally occurring polyphenol that has been suggested to improve several metabolic diseases. Leptin is an adipokine involved in metabolic status and appetite, with marked crosstalk with other systems. Available data suggest that curcumin may affect leptin levels; therefore, this meta-analysis was performed to evaluate this. A systematic review and meta-analysis were undertaken on all randomized controlled trials of curcumin studies that included the measurement of leptin. The search included PubMed-Medline, Scopus, ISI Web of Knowledge, and Google Scholar databases...
September 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28875471/optimization-of-curcuma-oil-quinine-loaded-nanocapsules-for-malaria-treatment
#14
Graziela Scheuer Gomes, Tamara Ramos Maciel, Eduarda Martini Piegas, Luana Roberta Michels, Letícia Marques Colomé, Rodrigo José Freddo, Daiana Silva de Ávila, Andre Gundel, Sandra Elisa Haas
Quinine, a treatment used in chloroquine-resistant falciparum malaria, was loaded into poly(ɛ-caprolactone) or Eudragit(®) RS100 nanocapsules using Curcuma oil as the oil-based core. Until now, the effect of cationic nanocapsules on malaria has not been reported. A 2(4) factorial design was adopted using, as independent variables, the concentration of Curcuma oil, presence of quinine, type of polymer, and aqueous surfactant. Diameter, zeta potential, and pH were the responses studied. The formulations were also evaluated for drug content, encapsulation efficiency, photostability, and antimalarial activity against Plasmodium berghei-infected mice...
September 5, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28837227/enrichment-and-cytotoxic-activity-of-curcuminoids-from-turmeric-using-macroporous-resins
#15
Cheng Chen, Shuna Jin, Xingliang Xiang, Xuanyuan Wang, Qingxin Shi, Min Yang, Simin Ji, Rongzeng Huang, Chengwu Song
Curcuminoids are functional secondary metabolites abundant in turmeric. In the present study, a simple and efficient method for enrichment of curcuminoids from turmeric was developed using macroporous resin. Eight different types of macroporous resins were examined by static adsorption/desorption properties and the type of XDA-7 was selected as the optimum one. Under the optimized conditions, the final contents of refined extract excluded 84.2% of impurities, by comparison with crude extract in a scale-up experiment...
August 24, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28835544/optimization-of-fermentation-conditions-for-the-production-of-curcumin-by-engineered-escherichia-coli
#16
Márcia R Couto, Joana L Rodrigues, Lígia R Rodrigues
Curcumin is a plant secondary metabolite with outstanding therapeutic effects. Therefore, there is a great interest in developing new strategies to produce this high-value compound in a cheaper and environmentally friendly way. Curcumin heterologous production in Escherichia coli using artificial biosynthetic pathways was previously demonstrated using synthetic biology approaches. However, the culturing conditions to produce this compound were not optimized and so far only a two-step fermentation process involving the exchange of culture medium allowed high concentrations of curcumin to be obtained, which limits its production at an industrial scale...
August 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28801864/isolation-and-characterization-of-iron-chelators-from-turmeric-curcuma-longa-selective-metal-binding-by-curcuminoids
#17
Donald J Messner, Christine Surrago, Celia Fiordalisi, Wing Yin Chung, Kris V Kowdley
Iron overload disorders may be treated by chelation therapy. This study describes a novel method for isolating iron chelators from complex mixtures including plant extracts. We demonstrate the one-step isolation of curcuminoids from turmeric, the medicinal food spice derived from Curcuma longa. The method uses iron-nitrilotriacetic acid (NTA)-agarose, to which curcumin binds rapidly, specifically, and reversibly. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin each bound iron-NTA-agarose with comparable affinities and a stoichiometry near 1...
August 11, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28796310/turmeric-extract-rescues-ethanol-induced-developmental-defect-in-the-zebrafish-model-for-fetal-alcohol-spectrum-disorder-fasd
#18
Pooja Muralidharan, Craig T Connors, Arooj S Mohammed, Swapnalee Sarmah, Kathleen Marrs, James A Marrs, Grady W Chism
Prenatal ethanol exposure causes the most frequent preventable birth disorder, fetal alcohol spectrum disorder (FASD). The effect of turmeric extracts in rescuing an ethanol-induced developmental defect using zebrafish as a model was determined. Ethanol-induced oxidative stress is one of the major mechanisms underlying FASD. We hypothesize that antioxidant inducing properties of turmeric may alleviate ethanol-induced defects. Curcuminoid content of the turmeric powder extract (5 mg/mL turmeric in ethanol) was determined by UPLC and found to contain Curcumin (124...
September 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28792522/biochemical-characterization-and-anti-inflammatory-properties-of-an-isothiocyanate-enriched-moringa-moringa-oleifera-seed-extract
#19
COMPARATIVE STUDY
Asha Jaja-Chimedza, Brittany L Graf, Charlotte Simmler, Youjin Kim, Peter Kuhn, Guido F Pauli, Ilya Raskin
Moringa oleifera Lam. is a tropical plant, used for centuries as food and traditional medicine. The aim of this study was to develop, validate and biochemically characterize an isothiocyanate-enriched moringa seed extract (MSE), and to compare the anti-inflammatory effects of MSE-containing moringa isothiocyanate-1 (MIC-1) with a curcuminoid-enriched turmeric extract (CTE), and a material further enriched in its primary phytochemical, curcumin (curcumin-enriched material; CEM). MSE was prepared by incubating ground moringa seeds with water to allow myrosinase-catalyzed enzymatic formation of bioactive MIC-1, the predominant isothiocyanate in moringa seeds...
2017: PloS One
https://www.readbyqxmd.com/read/28774574/fluoro-and-pentafluorothio-analogs-of-the-antitumoral-curcuminoid-ef24-with-superior-antiangiogenic-and-vascular-disruptive-effects
#20
Florian Schmitt, Madeleine Gold, Gerrit Begemann, Ion Andronache, Bernhard Biersack, Rainer Schobert
A series of 14 analogs of the curcuminoid EF24, (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone, bearing fluorine or pentafluorothio substituents, were prepared and tested for antiproliferative, vascular-disruptive, and antiangiogenic activity, as well as for their influence on other cancer-relevant targets. They proved antiproliferative against eight cancer cell lines with IC50 values in the low single-digit micromolar to triple-digit nanomolar range. Like EF24, the hexafluoro 3c and 3d and bis(pentafluorothio) 4f derivatives arrested HT-29 colon carcinoma cells in G2/M phase of the cell cycle, yet inhibited angiogenesis, e...
September 1, 2017: Bioorganic & Medicinal Chemistry
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