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https://www.readbyqxmd.com/read/29655717/encapsulation-of-curcumin-using-supercritical-antisolvent-sas-technology-to-improve-its-stability-and-solubility-in-water
#1
Álvaro Arango-Ruiz, Ángel Martin, María José Cosero, Claudio Jiménez, Julián Londoño
This study aims to develop a formulation of a turmeric-based dye extract using supercritical antisolvent (SAS) technology and different encapsulating polymers to improve the aqueous stability and solubility of curcumin. The dye formulation obtained by SAS consists of a mixture of Eudragit® L100 and Pluronic® 127 using tween 20 as a surfactant The characterization and quantification of curcumin extracts and the encapsulation product were conducted using high performance liquid chromatography (HPLC). The properties of the dye were determined using SEM, DSC, X-ray diffraction, particle size, zeta potential, and oxygen radical absorbance capacity (ORAC) to measure antioxidant capacity...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29642589/the-molecular-targets-and-anti-invasive-effects-of-2-6-bis-4-hydroxyl-3methoxybenzylidine-cyclohexanone-or-bhmc-in-mda-mb-231-human-breast-cancer-cells
#2
Siti Nor Aini Harun, Daud Ahmad Israf, Chau Ling Tham, Kok Wai Lam, Manraj Singh Cheema, Nur Fariesha Md Hashim
In order to metastasize, tumor cells need to migrate and invade the surrounding tissues. It is important to identify compound(s) capable of disrupting the metastasis of invasive cancer cells, especially for hindering invadopodia formation, so as to provide anti-metastasis targeted therapy. Invadopodia are thought to be specialized actin-rich protrusions formed by highly invasive cancer cells to degrade the extracellular matrix (ECM). A curcuminoid analogue known as 2,6-bis-(4-hydroxy-3-methoxybenzylidine)cyclohexanone or BHMC has shown good potential in inhibiting inflammation and hyperalgesia...
April 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29622343/efficacy-of-curcumin-and-boswellia-for-knee-osteoarthritis-systematic-review-and-meta-analysis
#3
Raveendhara R Bannuru, Mikala C Osani, Fatimah Al-Eid, Chenchen Wang
PURPOSE: The unfavorable safety profiles of commonly prescribed knee osteoarthritis (OA) treatments have led clinicians and patients to seek safer alternatives. Research has suggested that curcuminoid and boswellia formulations could moderate key inflammatory pathways that are associated with worsening symptoms and disease progression. We conducted a systematic review and meta-analysis to assess the efficacy and safety of these treatments vs. placebo or NSAIDs for knee OA. METHODS: We searched Medline, EMBASE, Google Scholar, Web of Science and the Cochrane database from inception to February 21, 2018...
March 10, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29610573/a-toxicological-evaluation-of-a-standardized-hydrogenated-extract-of-curcumin-curowhite%C3%A2
#4
Alastimmanahalli Narasimhiah Ravikumar, Joby Jacob, Sreeraj Gopi, Tumkur Subbarao Jagannath
A series of toxicological investigations were conducted in order to evaluate the genotoxic potential and repeated-dose oral toxicity of CuroWhite, a proprietary extract of curcumin that has been hydrogenated and standardized to not less than 25% hydrogenated curcuminoid content. All tests were conducted in general accordance with internationally accepted standards. The test item was not mutagenic in the bacterial reverse mutation test or in vitro mammalian chromosomal aberration test, and no in vivo genotoxic activity was observed in rat bone marrow in the micronucleus test...
2018: Journal of Toxicology
https://www.readbyqxmd.com/read/29602708/curcumin-and-its-demethoxy-derivatives-possess-p300-hat-inhibitory-activity-and-suppress-hypertrophic-responses-in-cardiomyocytes
#5
Yoichi Sunagawa, Masafumi Funamoto, Shogo Sono, Kana Shimizu, Satoshi Shimizu, Mai Genpei, Yusuke Miyazaki, Yasufumi Katanasaka, Eriko Morimoto, Morio Ueno, Maki Komiyama, Hideaki Kakeya, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other major curcuminoids isolated from Curcuma longa including demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are structural analogs of CUR. In present study, we first confirmed the effect of these three curcuminoid analogs on p300-HAT activity and cardiomyocyte hypertrophy...
March 13, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29593406/curcuminoid-loaded-poly-methyl-methacrylate-nanoparticles-for-cancer-therapy
#6
Abhispa Sahu, Pratima Solanki, Susmita Mitra
Curcuminoids (Curs), oleoresins from Curcuma longa L., have known anticarcinogenic and anti-inflammatory properties, but high toxicity, poor aqueous solubility and susceptibility to degradation in body fluids are deterrents to their clinical administration. Poly(methyl methacrylate) nanoparticles (PMMA-NPs) are biocompatible and resilient and can entrap hydrophobic drugs. The present investigation is related to solubilizing Curs by incorporating them in these nanoparticles (NPs) and is related to a study comparing the anticarcinogenic effect of drug-loaded NPs with free Cur using lung cancer (A549) cell line...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29570947/halogenated-bis-methoxy-benzylidene-4-piperidone-curcuminoids-with-improved-anticancer-activity
#7
Florian Schmitt, Dharmalingam Subramaniam, Shrikant Anant, Subhash Padhye, Gerrit Begemann, Rainer Schobert, Bernhard Biersack
A series of readily available curcuminoids 3a-f with halogenated bis(4-methoxy/4,5-dimethoxybenzylidene)-4-piperidone structure was prepared and analyzed for their cytotoxic impact on eight human cancer cell lines of five different entities. The known 3,4,5-trimethoxybenzylidene curcuminoid 2a and the new bis-(3-bromophenyl)- and bis-(3,5-dibromophenyl)-derivatives 3c and 3d proved more strongly antiproliferative than the known curcuminoid EF24 against six of these cell lines. Compounds 2a and 3c caused a distinct increase of reactive oxygen species, which eventually elicited apoptosis in 518A2 melanoma cells...
March 23, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29569909/thiol-reactivity-of-curcumin-and-its-oxidation-products
#8
Paula B Luis, William E Boeglin, Claus Schneider
The polypharmacological effects of the turmeric compound curcumin may be partly mediated by covalent adduction to cellular protein. Covalent binding to small molecule and protein thiols is thought to occur through a Michael-type addition at the enone moiety of the heptadienedione chain connecting the two methoxyphenol rings of curcumin. Here we show that curcumin formed the predicted thiol-Michael adducts with three model thiols, glutathione, N-acetylcysteine, and β-mercaptoethanol. More abundant, however, were respective thiol adducts of the dioxygenated spiroepoxide intermediate of curcumin autoxidation...
March 23, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29568669/synthesis-of-curcuminoid-imprinted-polymers-applied-to-the-solid-phase-extraction-of-curcuminoids-from-turmeric-samples
#9
Wisanu Thongchai, Pranom Fukngoen
A molecular imprinting polymer technique was successfully applied to precipitation polymerization by using styrene as a functional monomer, curcuminoids as templates, acetonitrile as a porogenic solvent, benzoyl peroxide as the initiator, and ethylene glycol dimethacrylate as the crosslinker. The effects of interaction on the adsorption capacity of the molecularly imprinted polymer (MIP) and non-imprinted polymer (NIP) were investigated. A comparison of the adsorption capacity for MIP and NIP indicated that the NIP had the lowest adsorption capacity...
February 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29565637/curcuminoids-from-curcuma-longa-new-adjuvants-for-the-treatment-of-crohn-s-disease-and-ulcerative-colitis
#10
Fernando Cunha Neto, Ledyane Taynara Marton, Sâmylla Vaz de Marqui, Tainah Aparecida Lima, Sandra Maria Barbalho
Crohn's Disease (CD) and Ulcerative Colitis (UC) result from an overreaction of the bowel to multifactorial stimuli leading to discomfort, pain, and it is associated with high morbidity and lethality. The medications commonly used are expensive and associated with multiple side effects. Curcuma longa exerts anti-inflammatory and antioxidant actions and has shown positive effects on CD and UC treatment, possibly due to the presence of curcuminoids. The objective of this review was to evaluate the role of curcuminoids in the treatment of IBD...
March 22, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29565326/curcuminoids-as-ebv-lytic-activators-for-adjuvant-treatment-in-ebv-positive-carcinomas
#11
Octavia Ramayanti, Mitch Brinkkemper, Sandra A W M Verkuijlen, Leni Ritmaleni, Mei Lin Go, Jaap M Middeldorp
Epstein-Barr virus (EBV) persists in nasopharyngeal (NPC) and gastric carcinomas (EBVaGC) in a tightly latent form. Cytolytic virus activation (CLVA) therapy employs gemcitabine and valproic acid (GCb+VPA) to reactivate latent EBV into the lytic phase and antiviral valganciclovir to enhance cell death and prevent virus production. CLVA treatment has proven safe in phase-I/II trials with promising clinical responses in patients with recurrent NPC. However, a major challenge is to maximize EBV lytic reactivation by CLVA...
March 22, 2018: Cancers
https://www.readbyqxmd.com/read/29556774/design-synthesis-and-cytotoxic-effects-of-curcuminoids-on-hela-k562-mcf-7-and-mda-mb-231-cancer-cell-lines
#12
Siti Noor Hajar Zamrus, Muhammad Nadeem Akhtar, Swee Keong Yeap, Ching Kheng Quah, Wan-Sin Loh, Noorjahan Banu Alitheen, Seema Zareen, Saiful Nizam Tajuddin, Yazmin Hussin, Syed Adnan Ali Shah
BACKGROUND: Curcumin is one of the leading compound extracted from the dry powder of Curcuma longa (Zingiberaceae family), which possess several pharmacological properties. However, in vivo administration exhibited limited applications in cancer therapies. RESULTS: Twenty-four curcumin derivatives have synthesized, which comprises cyclohexanone 1-10, acetone 11-17 and cyclopentanone 18-24 series. All the curcuminoids were synthesized by the acid or base catalyzed Claisen Schmidt condenstion reactions, in which β-diketone moiety of curcumin was modified with mono-ketone...
March 19, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29546309/supplementation-with-resveratrol-and-curcumin-does-not-affect-the-inflammatory-response-to-a-high-fat-meal-in-older-adults-with-abdominal-obesity-a-randomized-placebo-controlled-crossover-trial
#13
Cécile Vors, Charles Couillard, Marie-Eve Paradis, Iris Gigleux, Johanne Marin, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
Background: High-fat meals induce postprandial inflammation. Resveratrol is a polyphenol known to prevent comorbidities associated with cardiovascular disease and exerts an anti-inflammatory action. There is also an increasing body of evidence supporting the role of curcumin, a polyphenol from the curcuminoid family, as a modulator of proinflammatory processes. Objective: The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29535835/curcuminoid-submicron-particle-ameliorates-cognitive-deficits-and-decreases-amyloid-pathology-in-alzheimer-s-disease-mouse-model
#14
Yi-Heng Tai, Yu-Yi Lin, Kai-Chen Wang, Chao-Lin Chang, Ru-Yin Chen, Chia-Chu Wu, Irene H Cheng
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and is triggered via abnormal accumulation of amyloid-β peptide (Aβ). Aggregated Aβ is responsible for disrupting calcium homeostasis, inducing neuroinflammation, and promoting neurodegeneration. In this study, we generated curcuminoid submicron particle (CSP), which reduce the average size to ~60 nm in diameter. CSP had elevated the bioavailability in vivo and better neuroprotective effect against oligomeric Aβ than un-nanosized curcuminoids in vitro ...
February 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29535046/photodynamic-therapy-of-curcuma-longa-extract-stimulated-with-blue-light-against-aggregatibacter-actinomycetemcomitans
#15
Darika Saitawee, Aroon Teerakapong, Noppawan Phumala Morales, Paiboon Jitprasertwong, Doosadee Hormdee
BACKGROUND AND OBJECTIVE: Curcumin, one of an established curcuminoid substances extracted from Curcuma longa, has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Curcuminoid substances has been reported to have benefits in treating dental chronic infection and inflammation diseases, such as chronic periodontitis. The purpose of this study was to find the optimum concentration of Curcuma longa (CL) extract, containing all curcuminoid substances, and the power density of blue light (BL) in photodynamic therapy against periodontally pathogenic bacteria, A...
March 10, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29534559/phytoproflex%C3%A2-supplementary-management-of-osteoarthrosis-a-supplement-registry
#16
Gianni Belcaro, Mark Dugall, Roberta Luzzi, Morio Hosoi, Andrea Ledda, Beatrice Feragalli, Shu Hu, Apurba Ganguly, Roberto Eggenhoffner, Ambra Corti, Luca Giacomelli
BACKGROUND: Curcumin is a powerful anti-oxidant that can be used to treat inflammation and pain in chronic conditions such as osteoarthrosis (OA). Phytoproflex® is characterized by an innovative delivery system that improves bioavailability of curcuminoids and could be useful in the management of OA. METHODS: This 4-week registry included 56 patients with knee OA treated according to the best standard management for symptomatic OA. On top of that, 24 patients used Phytoproflex® supplement preparation (an extract containing boswellic acid 90%, curcumin 20% and valeric acid 0...
April 2018: Minerva Medica
https://www.readbyqxmd.com/read/29529492/simultaneous-quantification-of-free-curcuminoids-and-their-metabolites-in-equine-plasma-by-lc-esi-ms-ms
#17
Yongqiang Liu, Melissa Siard, Amanda Adams, Michael L Keowen, Travis K Miller, Frank Garza, Frank M Andrews, Navindra P Seeram
The human health benefits attributed to turmeric/curcumin spice has resulted in its wide utilization as a dietary supplement for companion pets and other animals including horses. While the quantification of free curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin) and their phase-2 metabolites (curcumin-O-sulfate, curcumin-O-glucuronide) have been extensively investigated in human and rodent biological samples (primarily plasma and serum), there is lack of similar data for horses. Herein, we report a validated LC-ESI-MS/MS method for the simultaneous quantification of the aforementioned free curcuminoids and their metabolites in equine plasma...
March 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29518605/herb-drug-interaction-of-nisha-amalaki-and-curcuminoids-with-metformin-in-normal-and-diabetic-condition-a-disease-system-approach
#18
Sushant Shengule, Kalyani Kumbhare, Dada Patil, Sanjay Mishra, Kishori Apte, Bhushan Patwardhan
Nisha Amalaki (NA), formulation with Curcuma longa Linn (Turmeric, Haridra, Nisha in Sanskrit; Family: Zingiberaceae) and Phyllanthus emblica Linn (Indian gooseberry, Amlaki in Sanskrit; Family: Phyllanthaceae) which is described for various diseases including diabetes in ayurvedic texts and Nighantus. The aim of the present study was to assess the pharmacokinetic (PK) and pharmacodynamic (PD) interactions of chemically standardized NA and Curcuminoids (CE) with metformin (MET) in normal and diabetic animals...
March 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29491199/inhibitory-effect-of-curcuminoid-pretreatments-on-endogenous-dentin-proteases
#19
Roda Seseogullari-Dirihan, Meltem Tekbas Atay, David Henry Pashley, Arzu Tezvergil-Mutluay
The aim of this study was to evaluate the effect of curcuminoids on the dentin endogenous protease activity. Demineralized dentin were pretreated with 50 or 100 µM of three different curcuminoids for 60 s and incubated up to 3 months. Untreated beams served as controls. Dry dentin mass was measured after incubation. Aliquots were analyzed for the quantity of ICTP and CTX releases for MMP and cathepsin-K mediated degradation, respectively. The effect of curcuminoids on matrix-bound MMP and soluble rhMMP-9 were measured using an activity assay...
February 27, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/29477768/inhibition-of-amyloid-fibrillation-of-lysozyme-by-bisdemethoxycurcumin-and-diacetylbisdemethoxycurcumin
#20
Fakhrossadat Mohammadi, Marzieh Moeeni, Afshin Mahmudian, Leila Hassani
Amyloid deposition, arising from the fibrillogenesis of proteins in organs and tissues of the body, causes several neurodegenerative disorders. One therapeutic approach is based on the use of polyphenols and their derivatives for suppressing and inhibiting the accumulation of these toxic fibrils in tissues. In the present study, the anti-amyloidogenic activities of bisdemethoxycurcumin (BDMC), a natural polyphenolic compound, and diacetylbisdemethoxycurcumin (DABC), a synthetic derivative of curcumin, on the amyloid fibrillation of hen egg white lysozyme (HEWL) is studied in depth using thioflavin T (ThT) fluorescence, atomic force microscopy (AFM), circular dichroism spectroscopy (CD), molecular docking and Ligplot calculations...
February 12, 2018: Biophysical Chemistry
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