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https://www.readbyqxmd.com/read/28430129/curcumin-inhibits-apoptosis-of-chondrocytes-through-activation-erk1-2-signaling-pathways-induced-autophagy
#1
Xiaodong Li, Kai Feng, Jiang Li, Degang Yu, Qiming Fan, Tingting Tang, Xiao Yao, Xiaoqing Wang
Osteoarthritis (OA) is an inflammatory disease of load-bearing synovial joints that is currently treated with drugs that exhibit numerous side effects and are only temporarily effective in treating pain, the main symptom of the disease. Consequently, there is an acute need for novel, safe, and more effective chemotherapeutic agents for the treatment of osteoarthritis and related arthritic diseases. Curcumin, the principal curcuminoid and the most active component in turmeric, is a biologically active phytochemical...
April 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28420097/synthesis-of-curcuminoids-and-evaluation-of-their-cytotoxic-and-antioxidant-properties
#2
María Concepción Lozada-García, Raúl G Enríquez, Teresa O Ramírez-Apán, Antonio Nieto-Camacho, Juan Francisco Palacios-Espinosa, Zeltzin Custodio-Galván, Olivia Soria-Arteche, Jaime Pérez-Villanueva
Curcumin (1) and ten derivatives (2-11) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC50) values for the more active compounds against HCT-15 and K562 cell lines. Compounds 2 and 10 were the most active against both cell lines and were more active than curcumin itself...
April 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28417091/biological-activities-of-curcuminoids-other-biomolecules-from-turmeric-and-their-derivatives-a-review
#3
REVIEW
Augustine Amalraj, Anitha Pius, Sreerag Gopi, Sreeraj Gopi
In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28417083/effects-of-turmeric-curcuminoids-and-metformin-against-central-sensitivity-to-pain-in-mice
#4
Suruchi Verma, Deepak Mundkinajeddu, Amit Agarwal, Shyam Sunder Chatterjee, Vikas Kumar
The reported experimental study was conducted to compare the effects of repeated daily oral doses of curcuminoids (CLE) with metformin as potential antidepressants and analgesics. Effects of a single and ten daily oral doses of CLE (5, 20, 80 mg/kg/day) and of 50 mg/kg/day metformin (MET) were compared in mice hot plate test (HPT) for analgesics. On the 11th treatment day, all animals were subjected to foot shock stress triggered hyperthermia test, and on the 12th treatment day to tail suspension test (TST) for antidepressants...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28415473/preparation-of-a-novel-bioavailable-curcuminoid-formulation-cureit%C3%A2-using-polar-nonpolar-sandwich-pns-technology-and-its-characterization-and-applications
#5
Augustine Amalraj, Shintu Jude, Karthik Varma, Joby Jacob, Sreeraj Gopi, Oluwatobi S Oluwafemi, Sabu Thomas
Health benefits of curcuminoid are highly limited due to their poor aqueous solubility, very low systemic bioavailability, fast metabolic alterations and rapid elimination. In this study, a novel bioavailable curcuminoid formulation Cureit™ was prepared by using Polar-Nonpolar-Sandwich (PNS) technology with complete natural turmeric matrix (CNTM). The synthesized bioavailable curcuminoid formulation Cureit™ was characterizations by Nuclear magnetic resonance spectroscopy (NMR), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infra-red (IR), current-voltage (I-V) study, Quadrupole Time-of-Flight Mass Spectrometry (Q-TOF), differential scanning calorimeter (DSC) and thermogravimetric analysis (TGA)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28401758/curcuminoid-demethylation-as-an-alternative-metabolism-by-human-intestinal-microbiota
#6
Supawadee Burapan, Mihyang Kim, Jaehong Han
Curcumin and other curcuminoids from Curcuma longa are important bioactive compounds exhibiting various pharmacological activities. In addition to the known reductive metabolism of curcuminoids, an alternative biotransformation of curcuminoids by human gut microbiota is reported herein. A curcuminoid mixture, composed of curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3) was metabolized by the human intestinal bacterium Blautia sp. MRG-PMF1. 1 and 2 were converted to new metabolites by the methyl aryl ether cleavage reaction...
April 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28399135/structure-based-comprehensive-modelling-spatial-fingerprints-mapping-and-adme-screening-of-curcumin-analogues-as-novel-alr2-inhibitors
#7
Sant Kumar Verma, Suresh Thareja
Aldose reductase (ALR2) inhibition is the most legitimate approach for the management of diabetic complications. The limited triumph in the drug development against ALR2 is mainly because of its close structural similarity with the other members of aldo-keto reductase (AKR) superfamily viz. ALR1, AKR1B10; and lipophilicity problem i.e. poor diffusion of synthetic aldose reductase inhibitors (ARIs) to target tissues. The literature evidenced that naturally occurring curcumin demonstrates relatively specific and non-competitive inhibition towards human recombinant ALR2 over ALR1 and AKR1B10; however β-diketone moiety of curcumin is a specific substrate for liver AKRs and accountable for it's rapid in vivo metabolism...
2017: PloS One
https://www.readbyqxmd.com/read/28362094/extraction-processing-and-storage-effects-on-curcuminoids-and-oleoresin-yields-from-curcuma-longa-l-grown-in-jamaica
#8
Cheryl E Green, Sheridan L Hibbert, Yvonne A Bailey-Shaw, Lawrence A D Williams, Sylvia Mitchell, Eric Garraway
No abstract text is available yet for this article.
March 31, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28319780/new-bis-hydroxymethyl-alkanoate-curcuminoid-derivatives-exhibit-activity-against-triple-negative-breast-cancer-in%C3%A2-vitro-and-in%C3%A2-vivo
#9
Min-Tsang Hsieh, Ling-Chu Chang, Hsin-Yi Hung, Hui-Yi Lin, Mei-Hui Shih, Chang-Hai Tsai, Sheng-Chu Kuo, Kuo-Hsiung Lee
Novel bis(hydroxymethyl) alkanoate curcuminoid derivatives were designed, synthesized and screened for in vitro antiproliferative and in vivo antitumor activity. Selected new compound 9a and curcumin were further evaluated for inhibitory activity against ER(+)/PR(+) breast cancer (MCF-7, T47D), HER 2(+) breast cancer (SKBR3, BT474, and MDA-MB-457) and triple negative breast cancer (TNBC) (HS-578T, MDA-MB-157, and MDA-MB-468) cell lines. In addition, compound 9a was evaluated in the MDA-MB-231 xenograft nude mice model...
March 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28303780/purity-evaluation-of-curcuminoids-in-the-turmeric-extract-obtained-by-accelerated-solvent-extraction
#10
Dinesh K Yadav, Khushbu Sharma, Anirban Dutta, Aditi Kundu, Akanksha Awasthi, Arnab Goon, Kaushik Banerjee, Supradip Saha
Curcuminoids, the active principle of <i>Curcuma longa </i>L, is one of the most researched subjects worldwide for its broad-spectrum biological activities. Being traditionally known for their anticancer properties and issues related to bioavailability, the curcuminoids, including diferuloylmethane (curcumin), have gained special attention. Thus, the current study focused on the purity profiling of curcuminoids when extracted by accelerated solvent extraction, which was run with turmeric rhizome powder (20 g) at 1500 psi and at 50°C, with a static time of 10 min and with three cycles...
March 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28302036/pharmacological-effects-of-turmeric-on-learning-memory-and-expression-of-muscarinic-receptor-genes-m1-m3-and-m5-in-stress-induced-mouse-model
#11
Aliya Khalid¥, Rabia Shakeel¥, Saira Justin, Ghazala Iqbal, Syed Adnan Ali Shah, Saadia Zahid, Touqeer Ahmed
Stress is involved in memory impairment by multiple mechanisms including activation of Hypothalamic-Pituitary Axis, which in turn activates release of corticosterone in blood. Cholinergic system blockade by muscarinic antagonist like scopolamine, also impairs memory. AIM: This study aimed to investigate the effect of turmeric (20mg/kg) on learning and memory and cholinergic system in a mouse model of stress along with cholinergic blockade. METHODS: Restrained stress was induced and cholinergic receptors were blocked using scopolamine in mice...
March 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28287280/comparison-of-antioxidant-anticholinesterase-and-antidiabetic-activities-of-three-curcuminoids-isolated-from-curcuma-longa-l
#12
Zeynep Kalaycıoğlu, Işıl Gazioğlu, F Bedia Erim
Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were controlled. Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity. The activity of demethoxycurcumin (DMC) followed BDMC, whereas curcumin showed very little acetylcholinesterase inhibition activity...
March 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28274102/production-of-curcuminoids-in-engineered-escherichia-coli
#13
Eun Ji Kim, Mi Na Cha, Bog-Gyu Kim, Joong-Hoon Ahn
Curcumin, a hydrophobic polyphenol derived from the rhizome of the herb Curcuma longa, possesses diverse pharmacological properties including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activity. Two curcuminoids (dicinnamoylmethane and bisdemethoxycurcumin) were synthesized from glucose in Escherichia coli. PAL (phenylalanine ammonia lyase) or TAL (tyrosine ammonia lyase), along with Os4CL (p-coumaroyl-CoA ligase) and CUS (curcumin synthase), were introduced in to E. coli, and each strain produced dicinnamoylmethane or bisdemethoxycurcumin, respectively...
March 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28261099/curcumin-a-potential-therapeutic-candidate-for-anterior-segment-eye-diseases-a-review
#14
REVIEW
Xiu-Fen Liu, Ji-Long Hao, Tian Xie, Nour Jama Mukhtar, Wiley Zhang, Tayyab Hamid Malik, Cheng-Wei Lu, Dan-Dan Zhou
Curcumin, the major curcuminoid of the turmeric, has been extensively used in many countries since ancient time for preventing and/or treating a multitude of diseases. This review is to illustrate the researches on the properties of curcumin and its potential therapeutic efficacy in major anterior segment eye diseases. The bio-medical potential of curcumin is restricted because of its low solubility and digestive bioavailability. This review will discuss promising research in improving curcumin bioavailability through structural modification...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28255993/curcuminoid-ef24-enhances-the-anti-tumor-activity-of-akt-inhibitor-mk-2206-through-ros-mediated-er-stress-and-mitochondrial-dysfunction-in-gastric-cancer
#15
Xi Chen, Xuanxuan Dai, Peng Zou, Weiqian Chen, Vinothkumar Rajamanickam, Chen Feng, Weishan Zhuge, Chenyu Qiu, Qingqing Ye, Xiaohua Zhang, Guang Liang
BACKGROUND AND PURPOSE: Gastric cancer is one of the leading causes of morbidity and mortality worldwide. Akt is an anti-apoptotic kinase that plays a dynamic role in cell survival and is implicated gastric cancer pathogenesis. MK-2206, the first allosteric inhibitor of Akt, is in clinical trials for a number of cancers. Although preclinical studies have shown promise, clinical trials reported lack of response when given alone at tolerated doses. The aim of our study is to delineate the effects of MK-2206 in gastric cancer cells and explore combinatorial treatments to enhance the anti-tumor activity of MK-2206...
March 3, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28236605/clinical-use-of-curcumin-in-depression-a-meta-analysis
#16
Qin Xiang Ng, Shawn Shao Hong Koh, Hwei Wuen Chan, Collin Yih Xian Ho
INTRODUCTION: There is growing interest in the use of curcumin, a plant polyphenol with potent anti-inflammatory, anti-oxidant, and neuroprotective properties, as a novel antidepressant. Clinical trials have yielded conflicting conclusions pertaining to its effectiveness in depression. A meta-analysis of the topic, which has not been done until now, is therefore necessary to summarize current evidence and generate hypotheses for further research. METHODS: Using the keywords [curcumin OR diferuloylmethane OR curcuminoid OR turmeric OR Indian saffron] AND [depression OR MDD OR suicide], a preliminary search on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group (CCDANTR), and Cochrane Field for Complementary Medicine database yielded 2081 articles published in English between January 1, 1960, and August 1, 2016...
February 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28236190/protective-role-of-tetrahydrocurcumin-an-active-polyphenolic-curcuminoid-on-cadmium-inducedoxidative-damage-in-rats
#17
Ramalingam Ramakrishnan, Perumal Elangovan, Leelavinothan Pari
In the present work, protective effect of tetrahydrocurcumin (THC) against oxidative damages in cadmium (Cd)-induced toxicity in rats was evaluated. Cd is an important environmental and industrial toxicant that affects almost all the organs, especially liver. Liver is the major organ responsible for the metabolism and the primary target for many toxic chemicals and drugs. Effect of THC, the curcumin-derived polyphenolic compound on Cd-induced oxidative stress and hepatic damage was evaluated using male albino Wistar rats...
February 24, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28204880/analysis-of-different-innovative-formulations-of-curcumin-for-improved-relative-oral-bioavailability-in-human-subjects
#18
Martin Purpura, Ryan P Lowery, Jacob M Wilson, Haider Mannan, Gerald Münch, Valentina Razmovski-Naumovski
PURPOSE: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO)...
February 16, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28178024/the-effects-of-curcuminoids-on-musculoskeletal-pain-a-systematic-review
#19
Andrew Gaffey, Helen Slater, Kylie Porritt, Jared M Campbell
BACKGROUND: Western countries are increasingly using complementary and alternative medicine (CAM) to assist with relieving ailments. Turmeric, from the ginger family Zingiberaceae, has a history of use for medicinal purposes. The polyphenols found in turmeric (curcuminoids) have demonstrated anti-inflammatory and pain relieving properties. With the use of CAMs increasing, it is important for the effectiveness of curcuminoids to be established. OBJECTIVES: To identify the effectiveness of the use of curcuminoids for the amelioration of musculoskeletal pain...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28160762/dietary-therapy-in-patients-with-inflammatory-arthritis
#20
Rauli Mäkelä, Heli Mäkilä, Ritva Peltomaa
Context • The exact etiology of rheumatoid disease is currently unknown. Changes in the microbiota of the gastrointestinal (GI) tract, chronic bacterial infection of the upper urinary tract, increased permeability of the GI tract, and food sensitivities have been classified among the factors that may cause or aggravate the disease. Dietary deficiencies also may render patients more susceptible to inflammatory conditions and disorders of the immunological system. Objective • The study intended to determine the effects of a therapy consisting of dietary elimination, dietary supplements, and probiotics, collectively called DDP therapy, which is given either independently or in combination with conventional pharmacological agents...
January 2017: Alternative Therapies in Health and Medicine
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