keyword
https://read.qxmd.com/read/37667099/association-of-race-ethnicity-persistent-poverty-and-opioid-access-among-patients-with-gastrointestinal-cancer-near-the-end-of-life
#21
JOURNAL ARTICLE
Muhammad Musaab Munir, Selamawit Woldesenbet, Yutaka Endo, Aslam Ejaz, Jordan M Cloyd, Samilia Obeng-Gyasi, Mary Dillhoff, Brittany Waterman, Jillian Gustin, Timothy M Pawlik
BACKGROUND: Social determinants of health (SDoH) can impact access to healthcare. We sought to assess the association between persistent poverty (PP), race/ethnicity, and opioid access among patients with gastrointestinal cancer near the end-of-life (EOL). METHODS: SEER-Medicare patients with gastric, liver, pancreatic, biliary, colon, and rectal cancer were identified between 2008 and 2016 near EOL, defined as 30 days before death or hospice enrolment. Data were linked with county-level poverty from the American Community Survey and the US Department of Agriculture (2000-2015)...
September 4, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37655097/a-machine-learning-based-model-for-predicting-distant-metastasis-in-patients-with-rectal-cancer
#22
JOURNAL ARTICLE
Binxu Qiu, Zixiong Shen, Song Wu, Xinxin Qin, Dongliang Yang, Quan Wang
BACKGROUND: Distant metastasis from rectal cancer usually results in poorer survival and quality of life, so early identification of patients at high risk of distant metastasis from rectal cancer is essential. METHOD: The study used eight machine-learning algorithms to construct a machine-learning model for the risk of distant metastasis from rectal cancer. We developed the models using 23867 patients with rectal cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2017...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37653287/risk-of-metastasis-and-survival-in-patients-undergoing-different-treatment-strategies-with-t1-colonic-neuroendocrine-tumors
#23
JOURNAL ARTICLE
X Wu, C Peng, M Lin, Z Li, X Yang, J Liu, X Yang, X Zuo
PURPOSE: The efficacy and safety of local excision (LE) for small (< 1‒2 cm) colonic neuroendocrine tumors (NETs) is controversial due to the higher metastasis risk when compared with rectal NETs. The study aimed to evaluate the metastasis risk of T1 colonic NETs and compare patients' long-term prognosis after LE or radical surgery (RS). METHODS: The Surveillance Epidemiology and End Results database was used to identify patients with T1 colonic NETs (2004‒2015)...
August 31, 2023: Journal of Endocrinological Investigation
https://read.qxmd.com/read/37629753/radiation-therapy-changed-the-second-malignancy-pattern-in-rectal-cancer-survivors
#24
JOURNAL ARTICLE
Xiaoxian Ye, Yinuo Tan, Ruishuang Ma, Pengrong Lou, Ying Yuan
Background and Objectives: Radiotherapy (RT) plays an important role in the treatment for locally advanced rectal cancer patients. It can bring radio exposure together with the survival benefit. Cancer survivors are generally at an increased risk for second malignancies, and survivors receiving RT may have higher risks than survivors not receiving RT. Whether the risk of an all-site second malignancy may increase after RT is still debated. This study aims to compare the second malignancy pattern in rectal cancer survivors after RT...
August 15, 2023: Medicina
https://read.qxmd.com/read/37435217/construction-and-validation-of-a-prognostic-nomogram-for-locally-recurrent-rectal-cancer-a-population-based-study
#25
JOURNAL ARTICLE
Xiao Huang, Minwei Zhou, Zhenyang Li, Ziheng Zhao, Yiming Zhou, Yiwen Zang, Yi Yang, Zihao Wang, Zongyou Chen, Xiaodong Gu, Jian Zhang, Jianbin Xiang
BACKGROUND: Postoperative recurrence was a life-threatening condition for patients with rectal cancer. Due to the heterogeneity of locally recurrent rectal cancer (LRRC) and controversy of the optimal treatment for patients, it was difficult to predict the prognosis of LRRC. This study aimed to develop and validate a nomogram that could accurately predict the survival probability of LRRC. METHODS: Patients diagnosed with LRRC between 2004 and 2019 from the Surveillance, Epidemiology, and End Results (SEER) database were included in the analysis...
June 30, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/37428195/optimal-examined-lymph-node-number-for-accurate-staging-and-long-term-survival-in-rectal-cancer-a-population-based-study
#26
JOURNAL ARTICLE
Xu Guan, Shuai Jiao, Rongbo Wen, Guanyu Yu, Jungang Liu, Dazhuang Miao, Ran Wei, Weiyuan Zhang, Liqiang Hao, Leqi Zhou, Zheng Lou, Shucheng Liu, Enliang Zhao, Guiyu Wang, Wei Zhang, Xishan Wang
BACKGROUND: Although the recommended minimal examined lymph node (ELN) number in rectal cancer (RC) is 12, this standard remains controversial because of insufficient evidence. We aimed to refine this definition by quantifying the relationship between ELN number, stage migration, and long-term survival in RC. METHODS: Data from a Chinese multi-institutional registry and the Surveillance, Epidemiology, and End Results (SEER) database on stage I to III resected RC (2008 - 2017) were analysed to determine the relationship between ELN count, stage migration, and overall survival (OS) using multivariable models...
July 10, 2023: International Journal of Surgery
https://read.qxmd.com/read/37293595/applying-machine-learning-techniques-to-predict-the-risk-of-lung-metastases-from-rectal-cancer-a-real-world-retrospective-study
#27
JOURNAL ARTICLE
Binxu Qiu, Zixiong Shen, Dongliang Yang, Quan Wang
BACKGROUND: Metastasis in the lungs is common in patients with rectal cancer, and it can have severe consequences on their survival and quality of life. Therefore, it is essential to identify patients who may be at risk of developing lung metastasis from rectal cancer. METHODS: In this study, we utilized eight machine-learning methods to create a model for predicting the risk of lung metastasis in patients with rectal cancer. Our cohort consisted of 27,180 rectal cancer patients selected from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2017 for model development...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37287925/treatment-paradigm-and-prognostic-factor-analyses-of-rectal-squamous-cell-carcinoma
#28
JOURNAL ARTICLE
Rui Liu, Jiahui Zhang, Yinjie Zhang, Jin Yan
BACKGROUND: Rectal squamous cell carcinoma (rSCC) is a rare pathological subtype of rectal cancer. There is no consensus on the treatment paradigm for patients with rSCC. This study aimed to provide a paradigm for clinical treatment and develop a prognostic nomogram. METHODS: Patients diagnosed with rSCC between 2010 and 2019 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. According to the TNM staging system, Kaplan-Meier (K-M) survival analysis was used to identify the survival benefits of different treatments in patients with rSCC...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37260988/early-onset-locally-advanced-rectal-cancer-characteristics-a-practical-nomogram-and-risk-stratification-system-a-population-based-study
#29
JOURNAL ARTICLE
Yang Su, Da Shuai Yang, Yan Qi Li, Jichao Qin, Lu Liu
BACKGROUND: The purpose of this study is to construct a novel and practical nomogram and risk stratification system to accurately predict cancer-specific survival (CSS) of early-onset locally advanced rectal cancer (EO-LARC) patients. METHODS: A total of 2440 patients diagnosed with EO-LARC between 2010 and 2019 were screened from the Surveillance, Epidemiology, and End Results (SEER) database. The pool of potentially eligible patients was randomly divided into two groups: a training cohort (N=1708) and a validation cohort (N=732)...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37215849/clinical-atlas-of-rectal-cancer-highlights-the-barriers-and-insufficient-interventions-underlying-the-unfavorable-outcomes-in-older-patients
#30
JOURNAL ARTICLE
Zhuoyang Zhao, Jinxin Lin, Shunlun Chen, Xiaolin Wang, Heng Wang, Gaopo Xu, Jianru Wang, Ruwen Zhou, Zenghong Huang, Yingjie Li, Yu Zhang, Xiaoxia Liu, Puning Wang, Meijin Huang, Yanxin Luo, Huichuan Yu
BACKGROUND: Aging confers an increased risk of developing cancer, and the global burden of cancer is cumulating as human longevity increases. Providing adequate care for old patients with rectal cancer is challenging and complex. METHOD: A total of 428 and 44,788 patients diagnosed with non-metastatic rectal cancer from a referral tertiary care center (SYSU cohort) and the Surveillance Epidemiology and End Results database (SEER cohort) were included. Patients were categorized into old (over 65 years) and young (aged 50-65 years) groups...
May 2023: Heliyon
https://read.qxmd.com/read/37201082/primary-tumor-location-impacts-survival-in-colorectal-cancer-patients-after-primary-resection-a-population%C3%A2-based-propensity-score-matching-cohort-study
#31
JOURNAL ARTICLE
Haipeng Yin, He Li, Jian Xu, Ju Wu
BACKGROUND: Right-sided colon cancers (R-CCs) are associated with worse outcomes compared to left-sided colon cancers (L-CCs). This study aimed to investigate whether a difference in survival existed among R-CC, L-CC, and rectal cancer (ReC) and subsequent liver metastasis. METHODS: Data from the Surveillance, Epidemiology, and End Results (SEER) database for 2010-2015 was used to identify colorectal cancer (CRC) patients who underwent surgical resection of primary disease...
April 29, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/37199862/adjuvant-chemotherapy-does-not-improve-cancer-specific-survival-for-pathologic-stage-ii-iii-rectal-adenocarcinoma-after-neoadjuvant-chemoradiotherapy-and-surgery-evidence-based-on-long-term-survival-analysis-from-seer-data
#32
JOURNAL ARTICLE
Hualin Liao, Tengyu Zeng, Xianqiang Xie, Jiyang Li, Dongsheng Li, KejinYan, Fan Chen, Hongliang Zhu
PURPOSE: Adjuvant chemotherapy is controversial in rectal cancer, especially after neoadjuvant chemoradiotherapy (NCRT). This retrospective study aims at evaluating adjuvant chemotherapy's long-term survival benefits in stage II and stage III rectal adenocarcinoma (RC). METHODS: This study obtained data from the Surveillance, Epidemiology, and End Results (SEER) database registered between 2010 and 2015. The survival analyses used the Kaplan-Meier method and were compared by log-rank test...
May 18, 2023: International Journal of Colorectal Disease
https://read.qxmd.com/read/37196346/increased-burden-of-second-bladder-cancer-and-rectal-cancer-in-prostate-cancer-treated-with-radiotherapy-results-from-surveillance-epidemiology-and-end-results
#33
JOURNAL ARTICLE
JinFang Lin, Xiangpeng Zhan, Ru Chen, Tao Chen, Ming Jiang, Yi Li, Xiaoqiang Liu, Guoxian Chen, Bin Fu
BACKGROUND: Previous studies have confirmed the higher risk of bladder cancer (BC) and rectal cancer (RC) development among prostate cancer (PCa) patients receiving radiotherapy. In this study, we intend to explore the long-term trend in second BC and RC incidence among PCa patients undergoing radiotherapy. METHOD: We identified first primary PCa patients diagnosed between 1975 and 2014 from the Surveillance, Epidemiology, and End Results (SEER)-9 cancer registries...
2023: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/37168349/a-nomogram-based-on-the-log-odds-of-positive-lymph-nodes-for-predicting-the-prognosis-of-t1-stage-rectal-cancer
#34
JOURNAL ARTICLE
Zixiang Guo, Weihua Li, Kaini Wu, Yunfeng Fu, Runwei Yan, Xiaodong Zhou
Early detection and timely treatment is the key to improving the prognosis of rectal cancer. Lymph node metastasis is one of the reasons for the poor prognosis of rectal cancer, especially early-stage rectal cancer. In this study, we developed a nomogram based on log odds of positive lymph nodes (LODDS) to predict cancer-specific survival (CSS) in patients with T1 rectal cancer. We included 1934 patients from the Surveillance, Epidemiology, and End Results (SEER) database and divided them into a training cohort and an in-validation cohort...
2023: American Journal of Cancer Research
https://read.qxmd.com/read/37154929/neoadjuvant-chemoradiotherapy-versus-neoadjuvant-chemotherapy-alone-for-patients-with-locally-advanced-rectal-cancer-a-propensity-score-matched-analysis-combined-with-seer-validation
#35
JOURNAL ARTICLE
Jingjing Wu, Mingzhe Huang, Yuanhui Wu, Yisong Hong, Linbin Cai, Rongzhao He, Yanxin Luo, Puning Wang, Meijin Huang, Jinxin Lin
BACKGROUND: Neoadjuvant therapy followed by radical surgery is recommended for locally advanced rectal cancer (LARC). But radiotherapy can cause potential adverse effects. The therapeutic outcomes, postoperative survival and relapse rates between neoadjuvant chemotherapy (N-CT) and neoadjuvant chemoradiotherapy (N-CRT) patients have rarely been studied. METHODS: From February 2012 to April 2015, patients with LARC who underwent N-CT or N-CRT followed by radical surgery at our center were included...
May 8, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37151355/development-and-validation-of-a-prognostic-nomogram-for-rectal-cancer-patients-who-underwent-surgical-resection
#36
JOURNAL ARTICLE
Bochao Zhao, Jingchao Wang, Zhicheng Ma, Haikun Ye, Tao Yang, Kewei Meng
Objective: The purpose of this study was to develop and validate a nomogram model for the prediction of survival outcome in rectal cancer patients who underwent surgical resection. Methods: A total of 9,919 consecutive patients were retrospectively identified using the Surveillance, Epidemiology, and End Results (SEER) database. Significant prognostic factors were determined by the univariate and multivariate Cox analysis. The nomogram model for the prediction of cancer-specific survival (CSS) in rectal cancer patients were developed based on these prognostic variables, and its predictive power was assessed by the concordance index (C-index)...
2023: Pathology Oncology Research: POR
https://read.qxmd.com/read/37148381/use-of-lymph-node-ratio-to-guide-clinical-decision-making-concerning-adjuvant-radiotherapy-in-pt1-2n1-rectal-cancer
#37
JOURNAL ARTICLE
Dakui Luo, Zilan Ye, Ruijia Zhang, Qingguo Li, Xinxiang Li
PURPOSE: Lymph node metastases are uncommon in pT1-2 rectal cancer. pT1-2N1 are often characterized with low tumor burden and intermediate prognosis. Therefore, adjuvant radiotherapy (ART) is controversial in these patients. This study aimed to investigate the value of ART in pT1-2 rectal cancer and evaluate the guiding role of lymph node ratio (LNR) for utilization of ART. METHODS: pT1-2N1 rectal cancer patients who received surgery without neoadjuvant radiotherapy between 2000 and 2018 with at least 12 lymph node harvest were extracted from the Surveillance, Epidemiology and End Results (SEER) database...
May 6, 2023: International Journal of Colorectal Disease
https://read.qxmd.com/read/37060832/age-related-differences-in-colon-and-rectal-cancer-survival-by-stage-histology-and-tumour-site-an-analysis-of-united-states-seer-18-data
#38
JOURNAL ARTICLE
Sophie Pilleron, Diana R Withrow, Brian D Nicholson, Eva J A Morris
Age-related differences in colon and rectal cancer survival have been observed, even after accounting for differences in background mortality. To determine how stage, tumour site, and histology contribute to these differences, we extracted age-specific one-year relative survival ratio (RS) stratified by these factors. We used colon and rectal cancer cases diagnosed between 2012 and 2016 from 18 United States Surveillance Epidemiology and End Results cancer registries. For colon cancer, 1-year RS ranged from 87...
April 13, 2023: Cancer Epidemiology
https://read.qxmd.com/read/36995458/mixed-adenoneuroendocrine-carcinoma-originating-from-the-appendix-and-colorectum-a-comparative-analysis-of-a-large-population-based-database
#39
JOURNAL ARTICLE
Bochao Zhao, Jingchao Wang, Haikun Ye, Xinghao Cheng, Kewei Meng, Tao Yang
PURPOSE: As a rare gastrointestinal neoplasm, the demographic, clinicopathological, and prognostic characteristics of mixed adenoneuroendocrine carcinoma (MANEC) remain unclear. The purpose of this study was to evaluate its biological features, survival outcome, and prognostic factors. METHODS: From the Surveillance, Epidemiology, and End Results (SEER) database, we retrospectively reviewed clinicopathological and survival data of 513 patients who were histopathologically diagnosed with MANEC of the appendix and colorectum bettween 2004 and 2015...
March 30, 2023: Techniques in Coloproctology
https://read.qxmd.com/read/36923430/a-nomogram-prediction-model-for-lymph-node-metastasis-risk-after-neoadjuvant-chemoradiotherapy-in-rectal-cancer-patients-based-on-seer-database
#40
JOURNAL ARTICLE
Xiaoshuang Liu, Li Sha, Cheng Huang, Xiancheng Kong, Feihu Yan, Xiaohui Shi, Xuefeng Tang
BACKGROUND: Rectal cancer patients who received neoadjuvant chemoradiotherapy (CRT) may have a lower cancer stage and a better prognosis. Some patients may be able to avoid invasive surgery. It is critical to accurately assess lymph node metastases (LNM) after neoadjuvant chemoradiotherapy. The goal of this study is to identify clinical variables associated with LNM and to develop a nomogram for LNM prediction in rectal cancer patients following nCRT. METHODS: From 2010 to 2015, patients were drawn from the Surveillance, Epidemiology, and End Results (SEER) database...
2023: Frontiers in Oncology
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