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rectal cancer SEER

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https://www.readbyqxmd.com/read/28351352/negative-lymph-node-count-is-an-independent-prognostic-factor-for-patients-with-rectal-cancer-who-received-preoperative-radiotherapy
#1
Xinxing Li, Hao Lu, Kai Xu, Haolu Wang, Xiaowen Liang, Zhiqian Hu
BACKGROUND: Negative lymph node (NLN) count has been reported to provide more accurate prognostic information than the N stage alone in patients with rectal cancer (RC). Since preoperative radiotherapy (Pre-RT) can significantly affect the LN status, it is unclear whether NLN count still has prognostic value count on survival of patients with RC who received Pre-RT. METHODS: In this study, clinicopathological characteristics, number of positive LNs and survival time were collected from Surveillance, Epidemiology, and End Results Program (SEER)-registered RC patients...
March 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28345614/prognosis-and-value-of-preoperative-radiotherapy-in-locally-advanced-rectal-signet-ring-cell-carcinoma
#2
Chun-Run Ling, Rui Wang, Mo-Jin Wang, Jie Ping, Wen Zhuang
As well known, signet-ring cell carcinoma (SRCC) is a rare histological subtype of colorectal adenocarcinoma, which has been associated with poor prognosis and resistant to non-surgery therapy compared with common adenocarcinoma. In this study, we assessed the effect of preoperative radiotherapy (PRT) for locally advanced rectal SRCC in a large patient group from the Surveillance, Epidemiology, and End Results program (SEER, 1988-2011) database. SRCC was found in 0.9% (n = 622) rectal cancer (RC) patients in our study...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28285840/secondary-malignancies-after-rectal-cancer-resection-with-and-without-radiation-therapy-a-propensity-adjusted-population-based-seer-analysis
#3
Rene Warschkow, Ulrich Güller, Thomas Cerny, Bruno Martin Schmied, Ludwig Plasswilm, Paul Martin Putora
BACKGROUND: The relationship between radiation therapy for rectal cancer and secondary malignancies is debated. The present study is the first population-based analysis using conventional multivariable analyses as well as propensity score matching to assess this relationship. METHODS: Overall, 77,484 patients after resection of localized or locally advanced rectal adenocarcinoma diagnosed between 1973 and 2012 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry...
March 9, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28272410/long-term-effect-of-radiotherapy-in-rectal-cancer-patients-with-mucinous-tumor-a-large-population-based-study
#4
Xu Guan, Senhao Jia, Wei Chen, Zheng Jiang, Zheng Liu, Yinggang Chen, Guiyu Wang, Xishan Wang
Due to distinct biological behavior of mucinous adenocarcinoma (MAC) and signet ring cell cancer (SRC), the efficacy of radiotherapy on long-term outcome for rectal cancer (RC) patients with mucinous tumors is still unclear. Here, we identified 1808 RC patients with MAC/SRC from Surveillance, Epidemiology, and End-Results (SEER) database from 2004 to 2013. Patients were divided into two subgroups according to different therapeutic strategies, including surgery alone and surgery combined with radiotherapy. Kaplan-Meier methods and Cox regression models were used to access the influence of therapeutic strategy on long-term survival outcomes...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197206/survival-after-abdominoperineal-and-sphincter-preserving-resection-in-nonmetastatic-rectal-cancer-a-population-based-time-trend-and-propensity-score-matched-seer-analysis
#5
Rene Warschkow, Sabrina M Ebinger, Walter Brunner, Bruno M Schmied, Lukas Marti
Background. Abdominoperineal resection (APR) has been associated with impaired survival in nonmetastatic rectal cancer patients. It is unclear whether this adverse outcome is due to the surgical procedure itself or is a consequence of tumor-related characteristics. Study Design. Patients were identified from the Surveillance, Epidemiology, and End Results database. The impact of APR compared to coloanal anastomosis (CAA) on survival was assessed by Cox regression and propensity-score matching. Results. In 36,488 patients with rectal cancer resection, the APR rate declined from 31...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28122523/adjuvant-radiotherapy-improves-cause-specific-survival-in-stage-ii-not-stage-iii-mucinous-carcinoma-of-the-rectum
#6
Qingguo Li, Yaqi Li, Weixing Dai, Sheng Wang, Ye Xu, Xinxiang Li, Sanjun Cai
BACKGROUND: The effect of adjuvant radiotherapy on the survival outcomes of patients with mucinous rectal cancer remains unclear. This study evaluated the 5-year cause specific survival (CSS) of patients with mucinous rectal cancer after surgery to determine whether adjuvant radiotherapy conferred a survival benefit. METHODS: An analysis of the Surveillance, Epidemiology, and End Results (SEER)-registered database was conducted of patients presenting with mucinous rectal cancer between 2004 and 2011...
January 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28096199/trends-in-radiation-therapy-among-cancer-survivors-in-the-united-states-2000-2030
#7
Alex K Bryant, Matthew Banegas, Maria E Martinez, Loren K Mell, James D Murphy
BACKGROUND: Although the number of cancer survivors has increased substantially over the past several decades, the composition of survivors treated with radiotherapy is not well defined. Radiotherapy carries unique long-term toxicity risks for cancer survivors. This study describes the current estimates and future projections of the epidemiology of five-year cancer survivors who receive radiation therapy. METHODS: We used cancer incidence and survival data from the Surveillance, Epidemiology, and End-Results (SEER) database linked to US Census data to estimate the number of five-year cancer survivors treated with radiation between 2000 and 2030...
January 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27806332/the-survival-and-clinicopathological-differences-between-patients-with-stage-iiia-and-stage-ii-rectal-cancer-an-analysis-of-12-036-patients-in-the-seer-database
#8
Ben Huang, Shaobo Mo, Liang Zhu, Tianhong Xu, Guoxiang Cai
BACKGROUND: Stage IIIA rectal cancer has distinctive oncological features, including limited depth of intestinal wall invasion and early regional lymph node metastasis. We aim to compare survival outcomes and clinicopathological features for stage IIIA rectal cancer with those for stage II rectal cancer. METHODS: We analyzed patients with stage II or stage IIIA rectal cancer treated with surgery without receiving preoperative radiotherapy based on data from the US Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2003...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27781400/comparison-of-outcomes-between-rectal-squamous-cell-carcinoma-and-adenocarcinoma
#9
Max S Chiu, Vivek Verma, Nathan R Bennion, Abhijeet R Bhirud, Jinluan Li, Mary E Charlton, Chandrakanth Are, Chi Lin
Large, population-based analyses of rectal squamous cell carcinoma (SCC) have not been previously conducted. We assessed patterns of care, prognostic factors, and outcomes of rectal SCC and adenocarcinoma (AC) in population-based cohorts. Surveillance, Epidemiology, and End Results (SEER) registry searches were performed (1998-2011), producing 42,308 nonmetastatic rectal cancer patients (999 SCC and 41,309 AC). Patient, tumor, and treatment characteristics were compared. Based on risk factors, SCC/AC groups were subdivided into low-, intermediate-, and high-risk groups...
December 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27762654/effect-of-increasing-radiation-dose-on-pathologic-complete-response-in-rectal-cancer-patients-treated-with-neoadjuvant-chemoradiation-therapy
#10
Matthew D Hall, Timothy E Schultheiss, David D Smith, Marwan G Fakih, Jeffrey Y C Wong, Yi-Jen Chen
BACKGROUND: Neoadjuvant chemoradiation therapy (CRT) increases pathological complete response (pCR) rates compared to radiotherapy alone in patients with stage II-III rectal cancer. Limited evidence addresses whether radiotherapy dose escalation further improves pCR rates. Our purpose is to measure the effects of radiotherapy dose and other factors on post-therapy pathologic tumor (ypT) and nodal stage in rectal cancer patients treated with neoadjuvant CRT followed by mesorectal excision...
December 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27716883/lodds-is-superior-to-lymph-node-ratio-for-the-prognosis-of-node-positive-rectal-cancer-patients-treated-with-preoperative-radiotherapy
#11
Ben Huang, Mengdong Ni, Chen Chen, Guoxiang Cai, Sanjun Cai
PURPOSE: Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT. METHODS: We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database...
January 21, 2017: Tumori
https://www.readbyqxmd.com/read/27507796/prognostic-significance-of-lymph-node-yield-in-ypn0-rectal-cancer
#12
M Raoof, R A Nelson, V N Nfonsam, J Warneke, R S Krouse
BACKGROUND: Neoadjuvant radiation therapy for locally advanced rectal adenocarcinoma decreases lymph node yield. This study investigated the association between survival and number of lymph nodes evaluated in patients with pathologically negative nodes after neoadjuvant therapy. METHODS: Patients with locally advanced rectal adenocarcinoma who underwent neoadjuvant therapy and had pathologically negative lymph nodes were included from the Surveillance, Epidemiology, and End Results (SEER) database over a 7-year interval (January 2004 to December 2010)...
November 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27449091/impact-of-sex-age-and-ethnicity-race-on-the-survival-of-patients-with-rectal-cancer-in-the-united-states-from-1988-to-2012
#13
Martin D Berger, Dongyun Yang, Yu Sunakawa, Wu Zhang, Yan Ning, Satoshi Matsusaka, Satoshi Okazaki, Yuji Miyamoto, Mitsukuni Suenaga, Marta Schirripa, Annika Medea Lenz, Pierre Bohanes, Afsaneh Barzi, Jane C Figueiredo, Diana L Hanna, Heinz-Josef Lenz
Most studies report on colon and rectal cancers collectively, even though biologic and prognostic differences exist between these disease entities. Here, we investigated the effects of sex, age, and ethnicity/race on rectal cancer (RC) mortality by stage focusing on differences before and after 2004.Using the SEER database, we identified 105,511 patients diagnosed with RC from 1988-2012. Main outcomes were disease-specific survival (DSS) and overall survival (OS).In patients with stage I-III RC, women achieved a longer DSS (HR 0...
August 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27356721/reduced-ovarian-cancer-incidence-in-women-exposed-to-low-dose-ionizing-background-radiation-or-radiation-to-the-ovaries-after-treatment-for-breast-cancer-or-rectosigmoid-cancer
#14
Steven Lehrer, Sheryl Green, Kenneth E Rosenzweig
BACKGROUND: High dose ionizing radiation can induce ovarian cancer, but the effect of low dose radiation on the development of ovarian cancer has not been extensively studied. We evaluated the effect of low dose radiation and total background radiation, and the radiation delivered to the ovaries during the treatment of rectosigmoid cancer and breast cancer on ovarian cancer incidence. MATERIALS AND METHODS: Background radiation measurements are from Assessment of Variations in Radiation Exposure in the United States, 2011...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27321382/log-odds-of-positive-lymph-nodes-is-a-superior-prognostic-indicator-in-stage-iii-rectal-cancer-patients-a-retrospective-analysis-of-17-632-patients-in-the-seer-database
#15
Ben Huang, Chen Chen, Mengdong Ni, Shaobo Mo, Guoxiang Cai, Sanjun Cai
BACKGROUND: Lymph node ratio (LNR) is considered a better staging system than N stage in rectal cancer. More recently, log odds of positive lymph nodes (LODDS) was identified as a novel prognostic classifier in many malignancies. Accordingly, our study aims to compare the predictive ability of LODDS with LNR for cancer-specific survival (CSS) in patients with stage III rectal cancer. METHODS: We analyzed a subpopulation of the Surveillance, Epidemiology and End Results (SEER) database containing patients with stage III rectal cancer...
August 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27070089/radiotherapy-dose-led-to-a-substantial-prolongation-of-survival-in-patients-with-locally-advanced-rectosigmoid-junction-cancer-a-large-population-based-study
#16
Xu Guan, Zheng Jiang, Tianyi Ma, Zheng Liu, Hanqing Hu, Zhixun Zhao, Dawei Song, Yinggang Chen, Guiyu Wang, Xishan Wang
Radiotherapy is widely applied for locally advanced rectal cancer (RC) to improve both local control and long-term outcomes. However, the efficacy of radiotherapy for rectosigmoid junction cancer (RSC) is still undetermined. Here, we identified 10074 patients who were diagnosed with locally advanced RSC from Surveillance, Epidemiology, and End-Results (SEER) cancer registry. These patients were divided into three subgroups according to different therapy strategies, including surgery alone, surgery plus preoperative radiotherapy and surgery plus postoperative radiotherapy...
May 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27069148/the-emerging-non-operative-management-of-non-metastatic-rectal-cancer-a-population-analysis
#17
Matthew J Abrams, Paul P Koffer, Kara L Leonard
AIM: Recent studies have piloted a nonoperative approach in patients with a complete clinical response to neoadjuvant chemoradiation for non-metastatic rectal cancer. This study evaluated these outcomes in the Surveillance, Epidemiology, and End Results (SEER) database. MATERIALS AND METHODS: Using SEER database 8.1.5, we identified patients diagnosed with stage II-III rectal adenocarcinoma between 2004-2011, treated with radiation alone (RT), RT then surgery (RT-S), or surgery then RT (S-RT)...
April 2016: Anticancer Research
https://www.readbyqxmd.com/read/26991915/preliminary-estimates-of-seer-cancer-incidence-for-2013
#18
Denise Riedel Lewis, Huann-Sheng Chen, Myles Cockburn, Xiao-Cheng Wu, Antoinette M Stroup, Douglas N Midthune, Martin F Krapcho, Daniel G Miller, Lynne Penberthy, Eric J Feuer
BACKGROUND: This article presents a first look at rates and trends for cases in the Surveillance, Epidemiology, and End Results (SEER) program diagnosed through 2013 using the February 2015 submission, and a validation of rates and trends from the February 2014 submission using the subsequent November 2014 submission. To the authors' knowledge, this is the second time SEER has published trends based on the early February submission. Three new cancer sites were added: cervix, thyroid, and liver/ intrahepatic bile duct...
May 15, 2016: Cancer
https://www.readbyqxmd.com/read/26856723/colorectal-specialization-increases-lymph-node-yield-evidence-from-a-national-database
#19
Arjun N Jeganathan, Skandan Shanmugan, Joshua I S Bleier, Glenn M Hall, Emily C Paulson
BACKGROUND: Current guidelines recommend the evaluation of at least 12 lymph nodes (LNs) in the pathologic specimen following surgery for colorectal cancer (CRC). We sought to examine the role of colorectal specialization on nodal identification. METHODS: We conducted a retrospective cohort study using SEER-Medicare data to examine the association between colorectal specialization and LN identification following surgery for colon and rectal adenocarcinoma between 2001 and 2009...
July 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26711638/secondary-cancers-after-radiation-therapy-for-primary-prostate-or-rectal-cancer
#20
REVIEW
Yen-Chien Lee, Chung-Cheng Hsieh, Chung-Yi Li, Jen-Pin Chuang, Jenq-Chang Lee
Literature about the risk of secondary cancer after radiation therapy (RT) of prostate and rectal cancer reveals contradictory results. We conducted a meta-analysis to examine whether the RT induces secondary rectal or prostate cancer in patients, respectively, with prostate or rectal cancer. All studies published in Medline or Pubmed up to March 3, 2015, containing RT of primary rectal or prostate cancer, and providing risk estimates of secondary prostate or rectal cancer were considered as eligible. Relative risk (RR) and standardized incidence ratios (SIR) were calculated using the random-effects model...
April 2016: World Journal of Surgery
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