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rectal cancer SEER

Ben Huang, Mengdong Ni, Chen Chen, Guoxiang Cai, Sanjun Cai
PURPOSE: Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT. METHODS: We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database...
October 3, 2016: Tumori
M Raoof, R A Nelson, V N Nfonsam, J Warneke, R S Krouse
BACKGROUND: Neoadjuvant radiation therapy for locally advanced rectal adenocarcinoma decreases lymph node yield. This study investigated the association between survival and number of lymph nodes evaluated in patients with pathologically negative nodes after neoadjuvant therapy. METHODS: Patients with locally advanced rectal adenocarcinoma who underwent neoadjuvant therapy and had pathologically negative lymph nodes were included from the Surveillance, Epidemiology, and End Results (SEER) database over a 7-year interval (January 2004 to December 2010)...
August 10, 2016: British Journal of Surgery
Martin D Berger, Dongyun Yang, Yu Sunakawa, Wu Zhang, Yan Ning, Satoshi Matsusaka, Satoshi Okazaki, Yuji Miyamoto, Mitsukuni Suenaga, Marta Schirripa, Annika Medea Lenz, Pierre Bohanes, Afsaneh Barzi, Jane C Figueiredo, Diana L Hanna, Heinz-Josef Lenz
Most studies report on colon and rectal cancers collectively, even though biologic and prognostic differences exist between these disease entities. Here, we investigated the effects of sex, age, and ethnicity/race on rectal cancer (RC) mortality by stage focusing on differences before and after 2004.Using the SEER database, we identified 105,511 patients diagnosed with RC from 1988-2012. Main outcomes were disease-specific survival (DSS) and overall survival (OS).In patients with stage I-III RC, women achieved a longer DSS (HR 0...
July 19, 2016: Oncotarget
Steven Lehrer, Sheryl Green, Kenneth E Rosenzweig
BACKGROUND: High dose ionizing radiation can induce ovarian cancer, but the effect of low dose radiation on the development of ovarian cancer has not been extensively studied. We evaluated the effect of low dose radiation and total background radiation, and the radiation delivered to the ovaries during the treatment of rectosigmoid cancer and breast cancer on ovarian cancer incidence. MATERIALS AND METHODS: Background radiation measurements are from Assessment of Variations in Radiation Exposure in the United States, 2011...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Ben Huang, Chen Chen, Mengdong Ni, Shaobo Mo, Guoxiang Cai, Sanjun Cai
BACKGROUND: Lymph node ratio (LNR) is considered a better staging system than N stage in rectal cancer. More recently, log odds of positive lymph nodes (LODDS) was identified as a novel prognostic classifier in many malignancies. Accordingly, our study aims to compare the predictive ability of LODDS with LNR for cancer-specific survival (CSS) in patients with stage III rectal cancer. METHODS: We analyzed a subpopulation of the Surveillance, Epidemiology and End Results (SEER) database containing patients with stage III rectal cancer...
August 2016: International Journal of Surgery
Xu Guan, Zheng Jiang, Tianyi Ma, Zheng Liu, Hanqing Hu, Zhixun Zhao, Dawei Song, Yinggang Chen, Guiyu Wang, Xishan Wang
Radiotherapy is widely applied for locally advanced rectal cancer (RC) to improve both local control and long-term outcomes. However, the efficacy of radiotherapy for rectosigmoid junction cancer (RSC) is still undetermined. Here, we identified 10074 patients who were diagnosed with locally advanced RSC from Surveillance, Epidemiology, and End-Results (SEER) cancer registry. These patients were divided into three subgroups according to different therapy strategies, including surgery alone, surgery plus preoperative radiotherapy and surgery plus postoperative radiotherapy...
May 10, 2016: Oncotarget
Matthew J Abrams, Paul P Koffer, Kara L Leonard
AIM: Recent studies have piloted a nonoperative approach in patients with a complete clinical response to neoadjuvant chemoradiation for non-metastatic rectal cancer. This study evaluated these outcomes in the Surveillance, Epidemiology, and End Results (SEER) database. MATERIALS AND METHODS: Using SEER database 8.1.5, we identified patients diagnosed with stage II-III rectal adenocarcinoma between 2004-2011, treated with radiation alone (RT), RT then surgery (RT-S), or surgery then RT (S-RT)...
April 2016: Anticancer Research
Denise Riedel Lewis, Huann-Sheng Chen, Myles Cockburn, Xiao-Cheng Wu, Antoinette M Stroup, Douglas N Midthune, Martin F Krapcho, Daniel G Miller, Lynne Penberthy, Eric J Feuer
BACKGROUND: This article presents a first look at rates and trends for cases in the Surveillance, Epidemiology, and End Results (SEER) program diagnosed through 2013 using the February 2015 submission, and a validation of rates and trends from the February 2014 submission using the subsequent November 2014 submission. To the authors' knowledge, this is the second time SEER has published trends based on the early February submission. Three new cancer sites were added: cervix, thyroid, and liver/ intrahepatic bile duct...
May 15, 2016: Cancer
Arjun N Jeganathan, Skandan Shanmugan, Joshua I S Bleier, Glenn M Hall, Emily C Paulson
BACKGROUND: Current guidelines recommend the evaluation of at least 12 lymph nodes (LNs) in the pathologic specimen following surgery for colorectal cancer (CRC). We sought to examine the role of colorectal specialization on nodal identification. METHODS: We conducted a retrospective cohort study using SEER-Medicare data to examine the association between colorectal specialization and LN identification following surgery for colon and rectal adenocarcinoma between 2001 and 2009...
July 2016: Annals of Surgical Oncology
Yen-Chien Lee, Chung-Cheng Hsieh, Chung-Yi Li, Jen-Pin Chuang, Jenq-Chang Lee
Literature about the risk of secondary cancer after radiation therapy (RT) of prostate and rectal cancer reveals contradictory results. We conducted a meta-analysis to examine whether the RT induces secondary rectal or prostate cancer in patients, respectively, with prostate or rectal cancer. All studies published in Medline or Pubmed up to March 3, 2015, containing RT of primary rectal or prostate cancer, and providing risk estimates of secondary prostate or rectal cancer were considered as eligible. Relative risk (RR) and standardized incidence ratios (SIR) were calculated using the random-effects model...
April 2016: World Journal of Surgery
Mary E Charlton, Jennifer E Hrabe, Kara B Wright, Jennifer A Schlichting, Bradley D McDowell, Thorvardur R Halfdanarson, Chi Lin, Karyn B Stitzenberg, John W Cromwell
BACKGROUND: Evidence suggests that high-volume facilities achieve better rectal cancer outcomes. METHODS: Logistic regression was used to evaluate association of facility type with treatment after adjusting for patient demographics, stage, and comorbidities. SEER-Medicare beneficiaries who were diagnosed with stage II/III rectal adenocarcinoma at age ≥66 years from 2005 to 2009 and had Parts A/B Medicare coverage for ≥1 year prediagnosis and postdiagnosis plus a claim for cancer-directed surgery were included...
May 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Qingguo Li, Lei Liang, Lu Gan, Guoxiang Cai, Xinxiang Li, Sanjun Cai
Lymph node (LN) status after surgery for rectal cancer is affected by preoperative radiotherapy. The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status after neoadjuvant radiotherapy on survival. A total of 1,650 patients receiving neoadjuvant chemotherapy in Surveillance, Epidemiology, and End Results Program (SEER)-registered ypIII stage rectal cancer was analyzed. We identified the optimal cutoff for retrieved LNs as 10 (χ2 = 14.006, P < 0...
2015: Scientific Reports
Xu Guan, Yinghu Jin, Yinggang Chen, Zheng Jiang, Zheng Liu, Zhixun Zhao, Peng Yan, Guiyu Wang, Xishan Wang
BACKGROUND: With the expanding population of colorectal cancer (CRC) survivors in the United States, one concerning issue is the risk of developing second primary malignancies (SPMs) for these CRC survivors. The present study attempts to identify the incidence characteristics of SPMs after diagnosis of first primary colon cancer (CC) and rectal cancer (RC). METHODS: 189,890 CC and 83,802 RC cases were identified from Surveillance, Epidemiology and End Results Program (SEER) database...
2015: PloS One
Joshua E Meyer, Steven J Cohen, Karen J Ruth, Elin R Sigurdson, Michael J Hall
BACKGROUND: The risk of lymph node positivity (LN+) in rectal cancer is a parameter that impacts therapeutic recommendations. We aimed to quantify the effect of younger age on LN+ in rectal cancer. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database, patients with rectal cancer diagnosed between 1988 and 2008 were identified. Patients were stage I-III, without preoperative radiotherapy, at least one lymph node examined, and a standard rectal cancer operation performed...
2015: Journal of the National Cancer Institute
Brett L Ecker, Emily C Paulson, Jashodeep Datta, Arjun N Jeganathan, Cary Aarons, Rachel R Kelz, Najjia N Mahmoud
BACKGROUND AND OBJECTIVES: Neoadjuvant chemoradiation (nCRT) for rectal adenocarcinoma reduces lymph node (LN) identification following surgical resection. We sought to evaluate the relationship between LN identification following nCRT and disease-specific survival (DSS), stratified by pathologic stage. METHODS: The SEER-Medicare database (2000-2009) was queried for 1,216 pathologic stage I-III rectal cancer patients who underwent nCRT followed by curative-intent resection...
September 2015: Journal of Surgical Oncology
Meredith S Shiels, Aimée R Kreimer, Anna E Coghill, Teresa M Darragh, Susan S Devesa
BACKGROUND: Although anal squamous cell carcinoma (SCC) and adenocarcinoma (ADC) are generally combined in cancer surveillance, their etiologies likely differ. Here, we describe demographic characteristics and trends in incidence rates (IR) of anal cancer by histology (SCC, ADC) and behavior (invasive, in situ) in the United States. METHODS: With data from the Surveillance, Epidemiology, and End Results (SEER) Program, we estimated age-adjusted anal cancer IRs across behavior/histology by demographic and tumor characteristics for 2000-2011...
October 2015: Cancer Epidemiology, Biomarkers & Prevention
Caitlin C Murphy, Linda C Harlan, Jennifer L Lund, Charles F Lynch, Ann M Geiger
BACKGROUND: Colorectal cancer (CRC) mortality has declined in the United States, in part because of advances in treatment. Few studies have evaluated the adoption of therapies and temporal changes in patterns of care. METHODS: Patients age 20 years and older diagnosed with stages II/III CRC were randomly sampled from the population-based Surveillance, Epidemiology, and End Results (SEER) program in 1990-1991, 1995, 2000, 2005, and 2010 (n = 7057). Therapy was obtained from medical records and physician verification...
October 2015: Journal of the National Cancer Institute
Karim Chamie, Stephen B Williams, Jim C Hu
IMPORTANCE: Many men with indolent prostate cancer often opt for radical prostatectomy or radiotherapy treatment for their disease. These men may experience considerable detriments of quality of life owing to sexual, urinary, and/or rectal toxic effects associated with these treatments. Without a better understanding of the mutable agents and predictors of treatment types, diffusion of expectant management among these men will be slow. OBJECTIVE: To determine population-based predictors for treatment and use of watchful waiting or active surveillance for indolent prostate cancer...
April 2015: JAMA Oncology
Jue-feng Wan, Ji Zhu, Gui-chao Li, Wen-jie Sun, Zhen Zhang
Patients were excluded if they were older than 75 years of age in most clinical trials. Thus, the optimal treatment strategies in elderly patients with locally advanced rectal cancer (LARC) are still controversial. We designed our study to specifically evaluate the cancer specific survival of four subgroups of patients according to four different treatment modalities: surgery only, radiation (RT) only, neoadjuvant RT and adjuvant RT by analyzing the Surveillance, Epidemiology, and End Results (SEER)-registered database...
October 6, 2015: Oncotarget
Gwen Murphy, Sanford M Dawsey, Eric A Engels, Winnie Ricker, Ruth Parsons, Arash Etemadi, Shih-Wen Lin, Christian C Abnet, Neal D Freedman
BACKGROUND & AIMS: Pernicious anemia, a result of autoimmune gastritis, is the most common cause of vitamin B12 deficiency, affecting 2% to 5% of the elderly population. Treatment with vitamin B12 cures the anemia, but not the gastritis. Findings from small studies have indicated that patients with pernicious anemia could have an increased risk of cancer. METHODS: We performed a population-based, case-control study of individuals in the Surveillance, Epidemiology, and End Results-Medicare database, comparing 1,138,390 cancer cases (age, 66-99 y) with 100,000 matched individuals without cancer (controls)...
December 2015: Clinical Gastroenterology and Hepatology
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