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https://www.readbyqxmd.com/read/28927079/new-use-of-microsatellite-instability-analysis-in-endometrial-cancer
#1
Haruko Kunitomi, Kouji Banno, Megumi Yanokura, Takashi Takeda, Moito Iijima, Kanako Nakamura, Miho Iida, Masataka Adachi, Keiko Watanabe, Yusuke Matoba, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki
The increasing incidence of obesity and diabetes due to changes in diet, earlier menarche, delayed menopause, late marriage, and declining birth rate have resulted in an increase in the number of endometrial cancer cases over the last few decades. Although surgical therapy is sufficient for early endometrial cancer, there is no effective therapy for patients with advanced and recurrent endometrial cancer. The oncogenic mechanism of endometrial cancer involves microsatellite instability (MSI) caused by dysfunction of DNA mismatch repair genes in 30% of patients...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926319/case-246-mr-imaging-of-a-complex-cystic-mass-in-a-newborn-girl
#2
Aditi Shruti, George S Wu
History A 6-day-old female neonate presented to the outpatient pediatric surgery clinic for evaluation of a possible prenatal abdominal mass. The neonate was delivered at term via cesarean section due to macrosomia, with a reported birth weight of 11 lb 8.7 oz (5.23 kg). The patient's postnatal course was remarkable for resolving neonatal hyperbilirubinemia. A physical examination was remarkable for a palpable mass in the abdomen. Maternal risk factors included class II obesity, type 2 diabetes, and metabolic syndrome...
October 2017: Radiology
https://www.readbyqxmd.com/read/28925332/spine-deformity-surgery-in-the-elderly-risk-factors-and-30-day-outcomes-are-comparable-in-posterior-versus-combined-approaches
#3
John K Yue, David C Sing, Sourabh Sharma, Pavan S Upadhyayula, Ethan A Winkler, Jeremy D Shaw, Lionel N Metz
Objectives Risk factors portending poor outcome following elective spine deformity fusion remain in need of characterization and stratification in the elderly population. Methods Cases aged ≥60 years who underwent elective posterior or anterior-posterior ('combined') fusion were extracted from the American College of Surgeons National Surgical Quality Improvement Program years 2007-2013 and analyzed by surgical cohort (posterior vs. combined). The 30-day outcomes included operation time, hospital length of stay (HLOS), perioperative complications, and discharge destination...
September 19, 2017: Neurological Research
https://www.readbyqxmd.com/read/28922254/obese-patients-undergoing-ileal-pouch-anal-anastomosis-short-and-long-term-surgical-outcomes
#4
Nicholas P McKenna, Kellie L Mathis, Mohammad A Khasawneh, Eric J Dozois, David W Larson, John H Pemberton, Amy L Lightner
BACKGROUND: Ileal pouch-anal anastomosis (IPAA) is the preferred surgical treatment for patients with chronic ulcerative colitis. Little is known about the impact of obesity on operative characteristics, short-term postoperative complications and long-term functional outcomes after IPAA. METHODS: A retrospective review of all patients undergoing IPAA for chronic ulcerative colitis at a single tertiary referral center between January 2002 and August 2013 was performed...
August 23, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28916485/moderate-intravenous-sedation-for-first-trimester-surgical-abortion-a-comparison-of-adverse-outcomes-between-obese-and-normal-weight-women
#5
Gillian Horwitz, Danielle Roncari, Kari Braaten, Rie Maurer, Jennifer Fortin, Alisa B Goldberg
OBJECTIVE: To determine if obese women experience increased rates of adverse outcomes with moderate intravenous sedation during first trimester surgical abortion compared to normal weight women. STUDY DESIGN: We performed a retrospective cohort study of all first trimester surgical abortions with moderate intravenous sedation at an outpatient facility between September 2010 and June 2015. The primary outcome was supplemental oxygen administration. Secondary outcomes included reversal agent administration, anesthesia-related adverse events, and intraoperative lowest level of consciousness (LLOC)...
September 13, 2017: Contraception
https://www.readbyqxmd.com/read/28915970/a-new-proposed-mechanism-of-action-for-gastric-bypass-surgery-air-hypothesis
#6
Hasan Celiker
Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric bypass. Instead, mounting evidence shows that altered neuroendocrine signaling is responsible for the weight reducing effects of RYGB. The exact mechanism of this surgical response is still a mystery...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28914835/-surgical-treatment-of-pain-syndrome-in-lumbar-spine-in-patients-with-obesity
#7
A G Aganesov, E G Gemdzhyan, A L Kheilo, K P Mikaelyan, M M Alexanyan
AIM: To analyze the reduction of pain severity, time of surgery, intraoperative blood loss, incidence of unintentional lesion of dura mater, infectious complications and hospital-stay after lumbar microdiscectomy. MATERIAL AND METHODS: The study included 104 patients aged 24-58 years (37 men and 67 women, mean age 45 years) who underwent lumbar microdiscectomy within January 2015 - June 2016. The main and control groups consisted of 48 and 56 patients with and without obesity respectively...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28914831/-technical-features-of-laparoscopic-cholecystectomy-in-patients-with-overweight-and-obesity
#8
I V Mikhin, А А Vorobiyov, M B Doronin, O A Kosivtsov, L A Ryaskov
AIM: To improve surgical treatment of patients with cholelithiasis and obesity by using of different technologies of laparoscopic cholecystectomy. MATERIAL AND METHODS: There were 88 (16.4%) patients with overweight and obesity among 538 patients who underwent laparoscopic cholecystectomy. Conventional laparoscopic cholecystectomy was performed in 33 (6.1%) cases, cholecystectomy through single laparoscopic access - in 12 (2.3%), cholecystectomy via single laparoscopic access with trocar support - in 43 (8...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28913484/identification-of-significant-obstructive-sleep-apnoea-in-the-obese-patient-development-of-the-novel-dx-osa-score
#9
Daniela D Godoroja, Dan Adrian Cioc
BACKGROUND AND OBJECTIVES: There is a high prevalence of undiagnosed obstructive sleep apnoea (OSA) in obese surgical patients. We investigated the extent to which anthropometric measurements can be used to identify the presence of significant OSA (Apnoea/Hypopnoea Index (AHI) ≥ 20) in adult patients. MATERIALS AND METHODS: We prospectively studied 1357 adult patients scheduled for elective laparoscopic bariatric surgery. Prior to surgery, body mass index (BMI), gender, neck circumference, STOP-Bang score, SpO2, neck and trunk fat (by dual X-ray absorptiometry) were recorded...
October 2016: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/28913357/the-association-of-uric-acid-calculi-with-obesity-prediabetes-type-2-diabetes-mellitus-and-hypertension
#10
Fang-Yeh Chu, Chih-Chun Chang, Pin-Hao Huang, Yi-Ning Lin, Po-Wen Ku, Jen-Tang Sun, Jung-Li Ho, Tzung-Hai Yen, Ming-Jang Su
OBJECTIVES: To disclose the link between the composition of urolithiasis, especially that of uric acid calculi, and obesity, prediabetes, type 2 diabetes mellitus, and hypertension. MATERIALS AND METHODS: Patients who had urinary calculi and underwent surgical treatment were registered in the study. The composition of urinary calculi was analyzed and correlated with clinical features and biomedical profiles of the patients before surgical intervention. RESULTS: A total of 666 patients with urolithiasis who underwent surgical management were registered and analyzed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28913120/effects-of-the-morbid-obesity-and-skin-incision-choices-on-surgical-outcomes-in-patients-undergoing-total-abdominal-hysterectomy
#11
Ebru Ersoy, Özlem Evliyaoğlu, Okyar Erol, Ali Özgür Ersoy, Mehmet Akif Akgül, Ali Haberal
OBJECTIVE: This study aimed to evaluate the effect of obesity on surgical outcomes in patients who underwent gynecologic surgery. MATERIALS AND METHODS: In total, we evaluated 132 patients who underwent total abdominal hysterectomy with or without salpingo-oophorectomy for benign gynecologic procedures at our tertiary referral gynaecology clinic. RESULTS: The non-morbid obese group [body mass index (BMI) <40 kg/m(2)] included 94 patients, and the morbid obese group (BMI ≥40 kg/m(2)) included 38 patients...
December 2016: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28912816/review-of-current-immunologic-therapies-for-hidradenitis-suppurativa
#12
REVIEW
Victoria K Shanmugam, Nadia Meher Zaman, Sean McNish, Faye N Hant
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of apocrine gland-bearing skin which affects approximately 1-4% of the population. The disease is more common in women and patients of African American descent and approximately one-third of patients report a family history. Obesity and smoking are known risk factors, but associations with other immune disorders, especially inflammatory bowel disease, are also recognized. The pathogenesis of HS is poorly understood and host innate or adaptive immune response, defective keratinocyte function, and the microbial environment in the hair follicle and apocrine gland have all been postulated to play a role in disease activity...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28912105/high-bmi-and-male-sex-as-risk-factor-for-increased-short-term-renal-impairment-in-living-kidney-donors-retrospective-analysis-of-289-consecutive-cases
#13
Lukas W Unger, Joy Feka, Philipp Sabler, Susanne Rasoul-Rockenschaub, Georg Györi, Michael Hofmann, Christoph Schwarz, Thomas Soliman, Georg Böhmig, Alexander Kainz, Andreas Salat, Gabriela A Berlakovich
BACKGROUND: Kidney transplantation represents the treatment of choice for end-stage renal disease (ESRD). However, nephrectomy bears certain short- as well as long-term risks for the healthy, voluntary donor. As obesity is increasing and is a known risk factor for surgical complications, we wanted to assess the impact of BMI on perioperative complication rates and renal function. MATERIALS AND METHODS: We retrospectively assessed patients undergoing living donor kidney nephrectomy at our institution...
September 11, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28906072/it-just-made-me-feel-so-desolate-patients-narratives-of-weight-gain-following-laparoscopic-insertion-of-a-gastric-band
#14
Frances Marjorie May Lloyd, Alistair Hewison, Nikolaos Efstathiou
AIMS AND OBJECTIVES: To describe the experiences of patients who have failed to maintain weight loss following the insertion of a Laparoscopic Adjustable Gastric Band (LAGB) for the treatment of morbid obesity. BACKGROUND: Obesity is a global health problem resulting in physical, psychological and economic problems, and presenting challenges for health services. Surgical intervention is an increasingly common approach to treatment, however some patients do not sustain their weight loss following bariatric surgery and little is known about people's longer-term experiences following LAGB insertion...
September 14, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28905453/sexual-steroids-in-serum-and-prostatic-tissue-of-human-non-cancerous-prostate-sterproser-trial
#15
Yann Neuzillet, Jean-Pierre Raynaud, Camélia Radulescu, Jean Fiet, Franck Giton, Jean-François Dreyfus, Tarek P Ghoneim, Thierry Lebret, Henry Botto
BACKGROUND: The specific involvement of the sex steroids in the growth of the prostatic tissue remains unclear. Sex steroid concentrations in plasma and in fresh surgical samples of benign central prostate were correlated to prostate volume. METHODS: Monocentric prospective study performed between September 2014 and January 2017. Age, obesity parameters, and both serum and intraprostatic concentrations of sex steroids were collected complying with the latest Endocrine Society guidelines and the steroids assessed by GC/MS...
September 14, 2017: Prostate
https://www.readbyqxmd.com/read/28905345/same-day-routine-chest-x-ray-after-thoracic-surgery-is-not-necessary
#16
Peter Nagy, Christiane Antony, Balazs Hegedüs, Sandra Kampe, Till Ploenes, Clemens Aigner, Stefan Welter
Introduction Performing a routine postoperative chest X-ray (CXR) after general thoracic surgery is daily practice in many thoracic surgery departments. The quality, frequency of pathological findings and the clinical consequences have not been well evaluated. Furthermore, exposure to ionising radiation should be restricted to a minimum and therefore routine practice can be questioned. Methods As a hospital standard, each patient was given a routine CXR after opening of the pleura and inserting a chest tube...
September 13, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28904522/endoscopic-pilonidal-sinus-treatment-long-term-results-of-a-prospective-series
#17
Gabriella Giarratano, Claudio Toscana, Mostafa Shalaby, Oreste Buonomo, Giuseppe Petrella, Pierpaolo Sileri
BACKGROUND AND OBJECTIVES: Pilonidal sinus is a common problem in the sacrococcygeal region, especially in obese, sedentary young men. The ideal surgical solution is still under debate, and there is a high rate of recurrence. In the present study, we analyzed the long-term results of a video-assisted minimally invasive technique for the treatment of sacrococcygeal pilonidal disease: endoscopic pilonidal sinus treatment (EPSiT). METHODS: From October 2013 through November 2015, a total of 77 consecutive patients (69 Males and 8 Females, median age: 23 y) were referred to our colorectal units...
July 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28902088/obesity-increases-risk-of-loss-of-reduction-after-casting-for-diaphyseal-fractures-of-the-radius-and-ulna-in-children-an-observational-cohort-study
#18
Christopher J DeFrancesco, Benjamin H Rogers, Apurva S Shah
OBJECTIVES: To determine if high body mass index (BMI) increases the risk of loss of reduction (LOR) following closed reduction and casting for displaced concomitant fractures of the radial and ulnar shafts in pediatric patients. DESIGN: Retrospective cohort study SETTING:: A single tertiary care, urban children's hospital PATIENTS/PARTICIPANTS:: Pediatric patients aged 2-18 years with closed, displaced, concomitant diaphyseal fractures of the radius and ulna (AO/OTA 22-A3) who underwent closed reduction and casting at the study site...
August 26, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28900886/the-effect-of-obesity-on-laparoscopic-and-robotic-assisted-colorectal-surgery-outcomes-an-acs-nsqip-database-analysis
#19
Jeffrey N Harr, Ivy N Haskins, Richard L Amdur, Samir Agarwal, Vincent Obias
Advantages of robotic-assisted colorectal surgery have been reported, but the effect on outcomes between obese and non-obese patients undergoing laparoscopic and robotic-assisted colorectal surgery remains unclear. Patients who underwent elective laparoscopic and robotic colon or rectal resections between 2012 and 2014 were identified in the ACS-NSQIP database. Propensity score matching was performed to determine the effect of obesity on laparoscopic and robotic-assisted 30-day surgical outcomes. 29,172 patients met inclusion criteria; 27,693 (94...
September 12, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28899517/metabolic-biomarkers-in-community-obese-children-effect-of%C3%A2-obstructive-sleep-apnea-and-its-treatment
#20
María Luz Alonso-Álvarez, Joaquin Terán-Santos, Mónica Gonzalez Martinez, José Aurelio Cordero-Guevara, María José Jurado-Luque, Jaime Corral-Peñafiel, Joaquin Duran-Cantolla, Estrella Ordax Carbajo, Fernando MasaJimenez, Leila Kheirandish-Gozal, David Gozal
OBJECTIVE: Obesity and obstructive sleep apnea in children have been associated with metabolic morbidities. The present study aimed to evaluate the presence of metabolic alterations among obese children recruited from the community, with and without obstructive sleep apnea syndrome (OSAS), and the impact of treatment of OSAS on metabolic profiles. METHODS: A cross-sectional, prospective, multicenter study of Spanish children aged 3-14 years with a body mass index (BMI) ≥95th percentile for age and sex were randomly selected in the first phase...
September 2017: Sleep Medicine
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