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https://www.readbyqxmd.com/read/27811932/thyroid-hormones-and-cardiovascular-disease
#1
REVIEW
Avais Jabbar, Alessandro Pingitore, Simon H S Pearce, Azfar Zaman, Giorgio Iervasi, Salman Razvi
Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are sensitive to changes in the concentrations of circulating thyroid hormones. The importance of thyroid hormones in maintaining cardiovascular homeostasis can be deduced from clinical and experimental data showing that even subtle changes in thyroid hormone concentrations - such as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome - adversely influence the cardiovascular system...
November 4, 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27810312/percutaneous-coronary-angioplasty-versus-coronary-artery-bypass-grafting-in-treatment-of-unprotected-left-main-stenosis-noble-a-prospective-randomised-open-label-non-inferiority-trial
#2
Timo Mäkikallio, Niels R Holm, Mitchell Lindsay, Mark S Spence, Andrejs Erglis, Ian B A Menown, Thor Trovik, Markku Eskola, Hannu Romppanen, Thomas Kellerth, Jan Ravkilde, Lisette O Jensen, Gintaras Kalinauskas, Rikard B A Linder, Markku Pentikainen, Anders Hervold, Adrian Banning, Azfar Zaman, Jamen Cotton, Erlend Eriksen, Sulev Margus, Henrik T Sørensen, Per H Nielsen, Matti Niemelä, Kari Kervinen, Jens F Lassen, Michael Maeng, Keith Oldroyd, Geoff Berg, Simon J Walsh, Colm G Hanratty, Indulis Kumsars, Peteris Stradins, Terje K Steigen, Ole Fröbert, Alastair N J Graham, Petter C Endresen, Matthias Corbascio, Olli Kajander, Uday Trivedi, Juha Hartikainen, Vesa Anttila, David Hildick-Smith, Leif Thuesen, Evald H Christiansen
BACKGROUND: Coronary artery bypass grafting (CABG) is the standard treatment for revascularisation in patients with left main coronary artery disease, but use of percutaneous coronary intervention (PCI) for this indication is increasing. We aimed to compare PCI and CABG for treatment of left main coronary artery disease. METHODS: In this prospective, randomised, open-label, non-inferiority trial, patients with left main coronary artery disease were enrolled in 36 centres in northern Europe and randomised 1:1 to treatment with PCI or CABG...
December 3, 2016: Lancet
https://www.readbyqxmd.com/read/27692595/local-versus-general-anesthesia-in-transcatheter-aortic-valve-replacement
#3
Avais Jabbar, Ayush Khurana, Ashfaq Mohammed, Rajiv Das, Azfar Zaman, Richard Edwards
Transcatheter aortic valve replacement (TAVR) is conventionally performed under general anesthesia (GA) allowing intraoperative transoesophageal echocardiogram imaging. We present our experience in patients having the procedure under local anesthesia (LA), who were subsequently transferred to a low dependency unit postprocedure, to assess safety and length of hospital stay. We retrospectively assessed all the transfemoral TAVR procedures conducted at our center from January 03, 2011. Of 216 patients, 145 had the procedure under GA and 71 under LA...
August 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27568119/does-the-routine-availability-of-ct-derived-ffr-influence-management-of%C3%A2-patients-with%C3%A2-stable-chest%C3%A2-pain-compared-to-ct%C3%A2-angiography%C3%A2-alone-the-ffrct-ripcord-study
#4
Nicholas P Curzen, James Nolan, Azfar G Zaman, Bjarne L Nørgaard, Ronak Rajani
OBJECTIVES: This study sought to determine the effect of adding computed tomography-derived fractional flow reserve (FFRCT) data to computed tomography angiographic (CTA) data alone for assessment of lesion severity and patient management in 200 patients with chest pain. BACKGROUND: Invasive and noninvasive tests used in the assessment of patients with angina all have disadvantages. The ideal screening test for patients presenting for the first time with chest pain would describe both coronary anatomy and the presence of ischemia and would be readily accessible, low cost, and noninvasive...
October 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27533946/p2y12-receptor-inhibitors-in-patients-with-non-st-elevation-acute-coronary-syndrome-in-the-real-world-use-patient-selection-and-outcomes-from-contemporary-european-registries
#5
Uwe Zeymer, Petr Widimsky, Nicolas Danchin, Maddalena Lettino, Alfredo Bardaji, Jose A Barrabes, Angel Cequier, Marc J Claeys, Leonardo De Luca, Jakob Dörler, David Erlinge, Paul Erne, Patrick Goldstein, Sasha M Koul, Gilles Lemesle, Thomas F Lüscher, Christian M Matter, Gilles Montalescot, Dragana Radovanovic, Jose Lopez Sendón, Petr Tousek, Franz Weidinger, Clive F M Weston, Azfar Zaman, Pontus Andell, Jin Li, J Wouter Jukema
AIMS: Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. METHODS AND RESULTS: A total of 10 registries (documenting 84 054 NSTE-ACS patients) provided data in a systematic manner on patient characteristics and outcomes for NSTE-ACS in general, and 6 of these (with 52 173 NSTE-ACS patients) also provided more specific data according to P2Y12 receptor inhibitor used...
October 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27533757/use-patient-selection-and-outcomes-of-p2y12-receptor-inhibitor-treatment-in-patients-with-stemi-based-on-contemporary-european-registries
#6
Nicolas Danchin, Maddalena Lettino, Uwe Zeymer, Petr Widimsky, Alfredo Bardaji, Jose A Barrabes, Angel Cequier, Marc J Claeys, Leonardo De Luca, Jakob Dörler, David Erlinge, Paul Erne, Patrick Goldstein, Sasha M Koul, Gilles Lemesle, Thomas F Lüscher, Christian M Matter, Gilles Montalescot, Dragana Radovanovic, Jose Lopez Sendón, Petr Tousek, Franz Weidinger, Clive F M Weston, Azfar Zaman, Pontus Andell, Jin Li, J Wouter Jukema
AIMS: Among acute coronary syndromes (ACS), ST-segment elevation myocardial infarction (STEMI) has the most severe early clinical course. We aimed to describe the effectiveness and safety of P2Y12 receptor inhibitors in patients with STEMI based on the data from contemporary European ACS registries. METHODS AND RESULTS: Twelve registries provided data in a systematic manner on outcomes in STEMI patients overall, and seven of these also provided data for P2Y12 receptor inhibitor-based dual antiplatelet therapy...
July 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27532447/contemporary-registries-on-p2y12-inhibitors-in-patients-with-acute-coronary-syndromes-in-europe-overview-and-methodological-considerations
#7
J Wouter Jukema, Maddalena Lettino, Petr Widimský, Nicolas Danchin, Alfredo Bardaji, Jose A Barrabes, Angel Cequier, Marc J Claeys, Leonardo De Luca, Jakob Dörler, David Erlinge, Paul Erne, Patrick Goldstein, Sasha M Koul, Gilles Lemesle, Thomas F Lüscher, Christian M Matter, Gilles Montalescot, Dragana Radovanovic, Jose Lopez-Sendón, Petr Tousek, Franz Weidinger, Clive F M Weston, Azfar Zaman, Uwe Zeymer
Patient registries that document real-world clinical experience play an important role in cardiology as they complement the data from randomized controlled trials, provide valuable information on drug use and clinical outcomes, and evaluate to what extent guidelines are followed in practice. The Platelet Inhibition Registry in ACS EvalUation Study (PIRAEUS) project is an initiative of registry holders who are managing national or international registries observing patients with acute coronary syndromes (ACS)...
October 2015: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27411839/primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction-in-nonagenarians
#8
Thibaut Petroni, Azfar Zaman, Jean-Louis Georges, Nadjib Hammoudi, Emmanuel Berman, Amit Segev, Jean-Michel Juliard, Olivier Barthelemy, Johanne Silvain, Rémi Choussat, Claude Le Feuvre, Gérard Helft
OBJECTIVE: To assess outcomes following primary percutaneous coronary intervention (PCI) for ST-segment elevation acute myocardial infarction (STEMI) in nonagenarian patients. METHODS: We conducted a multicentre retrospective study between 2006 and 2013 in five international high-volume centres and included consecutive all-comer nonagenarians treated with primary PCI for STEMI. There were no exclusion criteria. We enrolled 145 patients and collected demographic, clinical and procedural data...
October 15, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27342283/meta-analysis-of-the-prognostic-impact-of-anemia-in-patients-undergoing-percutaneous-coronary-intervention
#9
REVIEW
Chun Shing Kwok, Denise Tiong, Ashish Pradhan, Andreas Y Andreou, James Nolan, Olivier F Bertrand, Nick Curzen, Philip Urban, Phyo K Myint, Azfar G Zaman, Yoon K Loke, Mamas A Mamas
Anemia is common in patients undergoing percutaneous coronary intervention (PCI), and current guidelines fail to offer recommendations for its management. This review aims to examine the relation between baseline anemia and mortality, major adverse cardiovascular events (MACE), and major bleeding in patients undergoing PCI. We searched MEDLINE and EMBASE for studies that evaluated mortality and adverse outcomes in anemic and nonanemic patients who underwent PCI. Data were collected on study design, participant characteristics, definition of anemia, follow-up, and adverse outcomes...
August 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27165953/determinants-and-outcomes-of-stroke-following-percutaneous-coronary-intervention-by-indication
#10
Phyo Kyaw Myint, Chun Shing Kwok, Christine Roffe, Evangelos Kontopantelis, Azfar Zaman, Colin Berry, Peter F Ludman, Mark A de Belder, Mamas A Mamas
BACKGROUND AND PURPOSE: Stroke after percutaneous coronary intervention (PCI) is a serious complication, but its determinants and outcomes after PCI in different clinical settings are poorly documented. METHODS: The British Cardiovascular Intervention Society (BCIS) database was used to study 560 439 patients who underwent PCI in England and Wales between 2006 and 2013. We examined procedural-type specific determinants of ischemic and hemorrhagic stroke and the likelihood of subsequent 30-day mortality and in-hospital major adverse cardiovascular events (a composite of in-hospital mortality, myocardial infarction or reinfarction, and repeat revascularization)...
June 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27069103/outcomes-following-primary-percutaneous-coronary-intervention-in-patients-with-previous-coronary-artery-bypass-surgery
#11
Javaid Iqbal, Chun Shing Kwok, Evangelos Kontopantelis, Mark A de Belder, Peter F Ludman, Marilena Giannoudi, Mark Gunning, Azfar Zaman, Mamas A Mamas
BACKGROUND: There are limited data on outcomes of patients with previous coronary artery bypass grafting (CABG) presenting with ST-segment-elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI). We report outcomes in patients with STEMI undergoing PPCI with or without previous CABG surgery in a large real-world, all-comer population. METHODS AND RESULTS: Clinical, demographic, procedural, and outcomes data were collected for all patients undergoing PPCI in England and Wales from January 2007 to December 2012...
April 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26969759/changes-in-arterial-access-site-and-association-with-mortality-in-the-united-kingdom-observations-from-a-national-percutaneous-coronary-intervention-database
#12
Mamas A Mamas, James Nolan, Mark A de Belder, Azfar Zaman, Tim Kinnaird, Nick Curzen, Chun Shing Kwok, Iain Buchan, Peter Ludman, Evangelos Kontopantelis
BACKGROUND: The transradial access (TRA) site has become the default access site for percutaneous coronary intervention in the United Kingdom, with randomized trials and national registry data showing reductions in mortality associated with TRA use. This study evaluates regional changes in access site practice in England and Wales over time, examines whether changes in access site practice have been uniform nationally and across different patient subgroups, and provides national estimates for the potential number of lives saved or lost associated with regional differences in access site practice...
April 26, 2016: Circulation
https://www.readbyqxmd.com/read/26892086/1-year-follow-up-optical-frequency-domain-imaging-of-multiple-bioresorbable-vascular-scaffolds-for-the-treatment-of-spontaneous-coronary-artery-dissection
#13
Jonathan Watt, Mohaned Egred, Ayush Khurana, Alan J Bagnall, Azfar G Zaman
No abstract text is available yet for this article.
February 22, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26168217/t-lymphocytes-and-fractalkine-contribute-to-myocardial-ischemia-reperfusion-injury-in-patients
#14
Stephen E Boag, Rajiv Das, Evgeniya V Shmeleva, Alan Bagnall, Mohaned Egred, Nicholas Howard, Karim Bennaceur, Azfar Zaman, Bernard Keavney, Ioakim Spyridopoulos
BACKGROUND: Lymphocytes contribute to ischemia/reperfusion (I/R) injury in several organ systems, but their relevance in ST elevation myocardial infarction (STEMI) is unknown. Our goal was to characterize lymphocyte dynamics in individuals after primary percutaneous coronary intervention (PPCI), assess the prognostic relevance of these cells, and explore mechanisms of lymphocyte-associated injury. METHODS: Lymphocyte counts were retrospectively analyzed in 1,377 STEMI patients, and the prognostic relevance of post-PPCI lymphopenia was assessed by Cox proportional hazards regression...
August 3, 2015: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26093878/effect-of-access-site-gender-and-indication-on-clinical-outcomes-after-percutaneous-coronary-intervention-insights-from-the-british-cardiovascular-intervention-society-bcis
#15
Chun Shing Kwok, Evangelos Kontopantelis, Vijay Kunadian, Simon Anderson, Karim Ratib, Mathew Sperrin, Azfar Zaman, Peter F Ludman, Mark A de Belder, James Nolan, Mamas A Mamas
BACKGROUND: Gender is a strong predictor of periprocedural major bleeding complications after percutaneous coronary intervention (PCI). The access site represents an important site of such bleeding complications, which has driven adoption of the transradial access (TRA) use during PCI, although female gender is an independent predictor of transradial PCI failure. This study sought to define gender differences in access site practice and study associations between access site choice and clinical outcomes for PCI over a 6-year period, through the analysis of the British Cardiovascular Intervention Society observational database...
July 2015: American Heart Journal
https://www.readbyqxmd.com/read/25963155/neurocutaneous-melanosis-review-of-a-rare-non-familial-neuroectodermal-dysplasia-with-newer-association-of-cerebellopontine-angle-cistern-lipoma
#16
Mohammed Azfar Siddiqui, Shaista Siddiqui, Nuzhat Zaman, Ibne Ahmad, Ekram Ullah
Neurocutaneous melanosis is a rare neuroectodermal dysplasia with a grave prognosis. It is actually a disorder of neuronal migration at the time of the embryogenesis hence classified as a neurocristopathy. The patients are initially identified by the skin manifestations of the disease in the form of melanocytic naevus which can be hairy or non-hairy. These patients may or may not present with neurological symptoms but often show CNS abnormalities especially on MRI of the brain and the spine. A lot has been described about the disease since the first case described by Rokitansky in 1861, but every time a new CNS pathology is being added to the long list of currently documented pathologies...
April 2015: Neuroradiology Journal
https://www.readbyqxmd.com/read/25896077/stroke-following-percutaneous-coronary-intervention-type-specific-incidence-outcomes-and-determinants-seen-by-the-british-cardiovascular-intervention-society-2007-12
#17
Chun Shing Kwok, Evangelos Kontopantelis, Phyo K Myint, Azfar Zaman, Colin Berry, Bernard Keavney, Jim Nolan, Peter F Ludman, Mark A de Belder, Iain Buchan, Mamas A Mamas
AIMS: This study aims to evaluate temporal changes in stroke complications and their association with mortality and MACE outcomes in a national cohort of patients undergoing percutaneous coronary interventions (PCIs) in England and Wales. METHODS AND RESULTS: A total of 426 046 patients who underwent PCI in England and Wales between 2007 and 2012 in the British Cardiovascular Intervention Society (BCIS) database were analysed. Statistical analyses were performed evaluating the rates of stroke complications according to the year of PCI and multiple logistic regressions were used to evaluate the odds of 30-day mortality and in-hospital major adverse cardiovascular events (MACE; a composite of in-hospital mortality, myocardial infarction or re-infarction, and revascularization) with stroke complications...
July 1, 2015: European Heart Journal
https://www.readbyqxmd.com/read/25872532/thyroxine-in-acute-myocardial-infarction-thyrami-levothyroxine-in-subclinical-hypothyroidism-post-acute-myocardial-infarction-study-protocol-for-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Avais Jabbar, Lorna Ingoe, Simon Pearce, Azfar Zaman, Salman Razvi
BACKGROUND: Cardiac disease is the most common cause of morbidity and mortality in the United Kingdom. Even minor changes in thyroid hormone concentration may impact adversely on the cardiovascular system. Subclinical hypothyroidism (SCH) after admission for an acute cardiac problem has been associated with an increase in cardiac mortality and overall death. We have designed protocols for a prospective observational study to assess the association of thyroid function at the time of acute myocardial infarction (AMI) with cardiovascular outcomes, and a double-blinded randomised placebo-controlled trial of levothyroxine to evaluate its effect on LV function and vascular health...
March 25, 2015: Trials
https://www.readbyqxmd.com/read/25676689/impact-of-age-on-access-site-related-outcomes-in-469-983-percutaneous-coronary-intervention-procedures-insights-from-the-british-cardiovascular-intervention-society
#19
Simon G Anderson, Karim Ratib, Phyo K Myint, Bernard Keavney, Chun Shing Kwok, Azfar Zaman, Peter F Ludman, Mark A de Belder, James Nolan, Mamas A Mamas
We investigate adoption of the TRA in different age groups and study the relationship between age and access site related outcomes in a national cohort of patients undergoing PCI in the UK. Previous studies have reported conflicting data on radial access site adoption between different age groups, with age an independent predictor of failure of procedures undertaken through the radial approach. Age and access site related outcomes (based on transradial (TRA) and transfemoral (TFA) access) were studied in 469,983 PCI procedures undertaken in the UK from 2006 to 2012 in the age groups; <60, 60-<70, 70-<80, and ≥80 in the British Cardiovascular Intervention Society database...
November 15, 2015: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/25606697/atlantic-and-beyond-an-interview-with-professor-azfar-zaman
#20
Azfar Zaman, Wing Wu
Professor Azfar Zaman speaks to Wing Wu, Commissioning Editor: Professor Azfar Zaman is a Consultant Interventional Cardiologist at Freeman Hospital and Professor of Cardiology at Newcastle University. Following graduation at Leeds Medical School, he completed postgraduate training in cardiology at regional centres in Leeds, London and Cardiff. Prior to his appointment in Newcastle upon Tyne, he was a Fulbright Scholar and British Heart Foundation International Fellow at Mount Sinai Medical Center, New York, USA...
2015: Future Cardiology
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