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azfar Zaman

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https://www.readbyqxmd.com/read/29726633/the-impact-of-diabetes-on-the-prognostic-value-of-left-ventricular-function-following-percutaneous-coronary-intervention-insights-from-the-british-cardiovascular-intervention-society
#1
Matthew Jackson, David Austin, Chun Shing Kwok, Muhammad Rashid, Evan Kontopantelis, Peter Ludman, Mark de Belder, Mamas A Mamas, Azfar Zaman
OBJECTIVES: To study the relationship between diabetes mellitus (DM) and left ventricular (LV) function on outcomes following percutaneous coronary intervention (PCI). BACKGROUND: DM is a growing public health challenge worldwide and a significant risk factor for cardiovascular disease and heart failure. METHODS: All PCI procedures performed between 2006 and 2013 with LV function and diabetic status recorded in the BCIS-NICOR database were included...
May 4, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29673469/thyroid-hormones-and-cardiovascular-function-and-diseases
#2
REVIEW
Salman Razvi, Avais Jabbar, Alessandro Pingitore, Sara Danzi, Bernadette Biondi, Irwin Klein, Robin Peeters, Azfar Zaman, Giorgio Iervasi
Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29519382/vascular-access-site-and-outcomes-in-58-870-patients-undergoing-percutaneous-coronary-intervention-with-a-previous-history-of-coronary-bypass-surgery-results-from-the-british-cardiovascular-interventions-society-national-database
#3
Tim Kinnaird, Richard Anderson, Sean Gallagher, James Cockburn, Alex Sirker, Peter Ludman, Mark de Belder, Samuel Copt, James Nolan, Azfar Zaman, Mamas Mamas
OBJECTIVES: Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, access site choice and outcomes of patients undergoing PCI with previous coronary artery bypass grafting (CABG) were studied. BACKGROUND: Given the influence of access site on outcomes, use of radial access in PCI-CABG warrants further investigation. METHODS: Data were analyzed from 58,870 PCI-CABG procedures performed between 2005 and 2014...
March 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29498538/weekend-effect-in-acute-coronary-syndrome-a-meta-analysis-of-observational-studies
#4
Chun Shing Kwok, Mohammed Al-Dokheal, Sami Aldaham, Claire Rushton, Rob Butler, Tim Kinnaird, Azfar Zaman, M Justin Zaman, Adam Timmis, Mamas A Mamas
BACKGROUND: The effect of a weekend compared with a weekday hospital admission on patient outcomes after an acute coronary syndrome is unclear. This study aims to determine whether collectively there is a weekend effect in acute coronary syndrome. METHOD: We conducted a systematic review and meta-analysis of cohort studies examining the association between weekend compared to weekday admission at any time of the day and early mortality (in-hospital or 30-day). A search was performed on Medline and Embase and relevant studies were pooled using random effects meta-analysis for risk of early mortality...
March 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29356278/antiplatelet-drug-selection-in-pci-to-vein-grafts-in-patients-with-acute-coronary-syndrome-and-adverse-clinical-outcomes-insights-from-the-british-cardiovascular-intervention-society-database
#5
Alex Sirker, Chun Shing Kwok, Evangelos Kontopantelis, Tom Johnson, Philip Freeman, Mark A de Belder, Peter Ludman, Azfar Zaman, Mamas A Mamas
OBJECTIVE: This study aims to evaluate outcomes associated with different P2Y12 agents in Saphenous Vein graft (SVG) percutaneous coronary intervention (PCI). BACKGROUND: SVG PCI is associated with greater risks of ischemic complications, compared with native coronary PCI. Outcomes associated with the use of potent P2Y12 blocking drugs, Prasugrel and Ticagrelor, in SVG PCI are unknown. METHODS: Patients included in the study underwent SVG PCI in the United Kingdom between 2007 and 2014 for acute coronary syndrome and were grouped by P2Y12 antiplatelet use...
January 22, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29330481/fdxr-is-a-biomarker-of-radiation-exposure-in-vivo
#6
Gráinne O'Brien, Lourdes Cruz-Garcia, Matthäus Majewski, Jakub Grepl, Michael Abend, Matthias Port, Aleš Tichý, Igor Sirak, Andrea Malkova, Ellen Donovan, Lone Gothard, Sue Boyle, Navita Somaiah, Elizabeth Ainsbury, Lucyna Ponge, Krzysztof Slosarek, Leszek Miszczyk, Piotr Widlak, Edward Green, Neel Patel, Mahesh Kudari, Fergus Gleeson, Volodymyr Vinnikov, Viktor Starenkiy, Sergii Artiukh, Leonid Vasyliev, Azfar Zaman, Christophe Badie
Previous investigations in gene expression changes in blood after radiation exposure have highlighted its potential to provide biomarkers of exposure. Here, FDXR transcriptional changes in blood were investigated in humans undergoing a range of external radiation exposure procedures covering several orders of magnitude (cardiac fluoroscopy, diagnostic computed tomography (CT)) and treatments (total body and local radiotherapy). Moreover, a method was developed to assess the dose to the blood using physical exposure parameters...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29131802/acute-and-one-year-clinical-outcomes-following-implantation-of-bioresorbable-vascular-scaffolds-the-absorb-uk-registry
#7
Andreas Baumbach, Azfar Zaman, Nick E J West, Peter O'Kane, Mohaned Egred, Thomas Johnson, Stephen Wheatcroft, Ruth Bowles, Adam de Belder, Georgios Bouras, Alexandra Lansky, Jonathan Hill, Anthony Mathur, Mark A de Belder, Adrian P Banning
AIMS: The aim of this registry was to monitor practice patterns and outcomes in patients treated with Absorb bioresorbable vascular scaffolds (BVS) during the early phase of usage in the UK. METHODS AND RESULTS: A total of 1,005 patients with de novo coronary lesions were treated using careful implantation techniques at 24 centres. Follow-up at one year was obtained in 99%. An independent clinical events committee and angiographic core lab adjudicated all events...
January 20, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29020367/clinical-outcomes-of-state-of-the-art-percutaneous-coronary-revascularization-in-patients-with-de-novo-three-vessel-disease-1-year-results-of-the-syntax-ii-study
#8
Javier Escaned, Carlos Collet, Nicola Ryan, Giovanni Luigi De Maria, Simon Walsh, Manel Sabate, Justin Davies, Maciej Lesiak, Raul Moreno, Ignacio Cruz-Gonzalez, Stephan P Hoole, Nick Ej West, J J Piek, Azfar Zaman, Farzin Fath-Ordoubadi, Rodney H Stables, Clare Appleby, Nicolas van Mieghem, Robert Jm van Geuns, Neal Uren, Javier Zueco, Pawel Buszman, Andres Iñiguez, Javier Goicolea, David Hildick-Smith, Andrzej Ochala, Dariusz Dudek, Colm Hanratty, Rafael Cavalcante, Arie Pieter Kappetein, David P Taggart, Gerrit-Anne van Es, Marie-Angèle Morel, Ton de Vries, Yoshinobu Onuma, Vasim Farooq, Patrick W Serruys, Adrian P Banning
Aims: To investigate if recent technical and procedural developments in percutaneous coronary intervention (PCI) significantly influence outcomes in appropriately selected patients with three-vessel (3VD) coronary artery disease. Methods and results: The SYNTAX II study is a multicenter, all-comers, open-label, single arm study that investigated the impact of a contemporary PCI strategy on clinical outcomes in patients with 3VD in 22 centres from four European countries...
November 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28965096/effect-of-weekend-admission-on-process-of-care-and-clinical-outcomes-for-the-management-of-acute-coronary-syndromes-a-retrospective-analysis-of-three-uk-centres
#9
Glen P Martin, Tim Kinnaird, Matthew Sperrin, Richard Anderson, Amr Gamal, Avais Jabbar, Chun Shing Kwok, Diane Barker, Grant Heatlie, Azfar G Zaman, Mamas A Mamas
OBJECTIVES: The effect of weekend versus weekday admission following acute coronary syndrome (ACS) on process of care and mortality remains controversial. This study aimed to investigate the 'weekend-effect' on outcomes using a multicentre dataset of patients with ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction/unstable angina (NSTEMI/UA). DESIGN: This retrospective observational study used propensity score (PS) stratification to adjust estimates of weekend effect for observed confounding...
September 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28916604/coronary-perforation-complicating-percutaneous-coronary-intervention-in-patients-with-a-history-of-coronary-artery-bypass-surgery-an-analysis-of-309-perforation-cases-from-the-british-cardiovascular-intervention-society-database
#10
Tim Kinnaird, Richard Anderson, Nick Ossei-Gerning, James Cockburn, Alex Sirker, Peter Ludman, Mark de Belder, Thomas W Johnson, Samuel Copt, Azfar Zaman, Mamas A Mamas
BACKGROUND: The evidence base for coronary perforation (CP) occurring during percutaneous coronary intervention in patients with a history of coronary artery bypass surgery (PCI-CABG) is limited and the long-term effects unclear. Using a national PCI database, the incidence, predictors, and outcomes of CP during PCI-CABG were defined. METHODS AND RESULTS: Data were analyzed on all PCI-CABG procedures performed in England and Wales between 2005 and 2013. Multivariate logistic regressions and propensity scores were used to identify predictors of CP and its association with outcomes...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28683933/the-relationship-of-body-mass-index-to-percutaneous-coronary-intervention-outcomes-does-the-obesity-paradox-exist-in-contemporary-percutaneous%C3%A2-coronary-intervention-cohorts-insights-from-the%C3%A2-british-cardiovascular-intervention-society-registry
#11
Eric W Holroyd, Alex Sirker, Chun Shing Kwok, Evangelos Kontopantelis, Peter F Ludman, Mark A De Belder, Robert Butler, James Cotton, Azfar Zaman, Mamas A Mamas
OBJECTIVES: The aims of this study were to examine the relationship between body mass index (BMI) and clinical outcomes following percutaneous coronary intervention (PCI) and to determine the relevance of different clinical presentations requiring PCI to this relationship. BACKGROUND: Obesity is a growing problem, and studies have reported a protective effect from obesity compared with normal BMI for adverse outcomes after PCI. METHODS: Between 2005 and 2013, 345,192 participants were included...
July 10, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28579168/drug-coated-versus-bare-metal-stents-for-elderly-patients-a-predefined-sub-study-of-the-leaders-free-trial
#12
Marie-Claude Morice, Suneel Talwar, Oliver Gaemperli, Gert Richardt, Franz Eberli, Ian Meredith, Azfar Zaman, Jean Fajadet, Samuel Copt, Samantha Greene, Philip Urban
BACKGROUND: The randomized, LEADERS FREE trial showed superior safety and efficacy of a polymer-free DCS vs. a bare metal stent in high-bleeding risk patients with only one month dual antiplatelet treatment. We report characteristics and outcomes of the pre-specified group of elderly patients (aged ≥75). METHODS: Age >75 was one of the trial's inclusion criteria. The main additional criteria were: need for oral anticoagulants, recent bleeding, anemia, chronic renal failure and cancer...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28404622/choice-of-stent-for-percutaneous-coronary-intervention-of-saphenous-vein-grafts
#13
MULTICENTER STUDY
Javaid Iqbal, Chun Shing Kwok, Evangelos Kontopantelis, Mark A de Belder, Peter F Ludman, Adrian Large, Rob Butler, Amr Gamal, Tim Kinnaird, Azfar Zaman, Mamas A Mamas
BACKGROUND: There are limited data on comparison of contemporary drug-eluting stent (DES) platforms, previous generation DES, and bare-metal stents (BMS) for percutaneous coronary intervention in saphenous vein grafts (SVG). We aimed to assess clinical outcomes following percutaneous coronary intervention to SVG in patients receiving bare-metal stents (BMS), first-generation DES, and newer generation DES in a large unselected national data set from the BCIS (British Cardiovascular Intervention Society)...
April 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28329196/diabetic-patients-with-acute-coronary-syndromes-in-contemporary-european-registries-characteristics-and-outcomes
#14
Maddalena Lettino, Pontus Andell, Uwe Zeymer, Petr Widimsky, Nicolas Danchin, Alfredo Bardaji, Jose A Barrabes, Angel Cequier, Marc J Claeys, Leonardo De Luca, Jakob Dörler, David Erlinge, Paul Erne, Patrick Goldstein, Sasha M Koul, Gilles Lemesle, Thomas F Lüscher, Christian M Matter, Gilles Montalescot, Dragana Radovanovic, Jose Lopez Sendón, Petr Tousek, Franz Weidinger, Clive F M Weston, Azfar Zaman, Jin Li, J Wouter Jukema
Aims: Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results: A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505)...
October 1, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28276254/a-risk-scoring-system-to-predict-coronary-stent-thrombosis
#15
Nikesh Malik, Amerjeet S Banning, Mark Belger, Walid Fakhouri, Peita L Graham-Clarke, Adrian Banning, Andreas Baumbach, Daniel J Blackman, Adam de Belder, Thierry Lefèvre, Rod Stables, Azfar Zaman, Anthony H Gershlick
OBJECTIVE: Stent thrombosis (ST) is a potentially life-threatening complication of percutaneous coronary intervention (PCI). We aimed to develop a scoring system to predict the risk of ST following PCI. RESEARCH DESIGN AND METHODS: Odds ratios (ORs) for risk factors associated with ST were identified from a meta-analysis based on a systematic literature review, and through consensus expert opinion (Delphi-RAND method). The combined ORs were used to calculate risk scores for acute (within 24 hours), early (within 30 days) and late (31 days to 1 year) ST...
May 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28228456/preeclampsia-and-future-cardiovascular-health-a-systematic-review-and-meta-analysis
#16
REVIEW
Pensée Wu, Randula Haththotuwa, Chun Shing Kwok, Aswin Babu, Rafail A Kotronias, Claire Rushton, Azfar Zaman, Anthony A Fryer, Umesh Kadam, Carolyn A Chew-Graham, Mamas A Mamas
BACKGROUND: Preeclampsia is a pregnancy-specific disorder resulting in hypertension and multiorgan dysfunction. There is growing evidence that these effects persist after pregnancy. We aimed to systematically evaluate and quantify the evidence on the relationship between preeclampsia and the future risk of cardiovascular diseases. METHODS AND RESULTS: We studied the future risk of heart failure, coronary heart disease, composite cardiovascular disease, death because of coronary heart or cardiovascular disease, stroke, and stroke death after preeclampsia...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28035491/cancer-event-rate-and-mortality-with-thienopyridines-a-systematic-review-and-meta-analysis
#17
REVIEW
Rafail Angelos Kotronias, Chun Shing Kwok, Chun Wai Wong, Tim Kinnaird, Azfar Zaman, Mamas A Mamas
INTRODUCTION: Thienopyridines are a class of antiplatelet drugs widely used in cardiovascular disease prevention and treatment. A recent concern has come to light regarding the safety of thienopyridines because of the possible risk of malignancy. We therefore performed a systematic review and meta-analysis to evaluate the association between thienopyridine exposure and malignancy. METHODS: We searched the MEDLINE and EMBASE databases in March 2016 for studies that evaluated incident cancer and cancer mortality with and without exposure to thienopyridines...
March 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28029209/mortality-after-percutaneous-coronary-revascularization-prior-cardiovascular-risk-factor-control-and-improved-outcomes-in-patients-with-diabetes-mellitus
#18
COMPARATIVE STUDY
Awsan Noman, Karthik Balasubramaniam, M Hafez A Alhous, Kelvin Lee, Peter Jesudason, Muhammad Rashid, Mamas A Mamas, Azfar G Zaman
OBJECTIVES: To assess the mortality in patients with diabetes mellitus (DM) following percutaneous coronary intervention (PCI) according to their insulin requirement and PCI setting (elective, urgent, and emergency). BACKGROUND: DM is a major risk factor to develop coronary artery disease (CAD). It is unclear if meticulous glycemic control and aggressive risk factor management in patients with DM has improved outcomes following PCI. METHODS: Retrospective analysis of prospectively collected data on 9,224 patients treated with PCI at a regional tertiary center between 2008 and 2011...
June 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27970333/tct-164-pressure-controlled-intermittent-coronary-sinus-occlusion-reduces-infarct-size-and-results-in-functional-recovery-after-stemi-interim-analysis-of-an-ongoing-trial
#19
Mohaned Egred, Alan Bagnall, Ioakim Spyridopoulos, Ian Purcell, Rajiv Das, Nick Palmer, Ever Grech, Ajay Jain, Gregg Stone, Robin Nijveldt, Roger Kessels, Azfar Zaman
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970208/tct-815-clinical-benefits-of-less-invasive-device-based-left-ventricular-reconstruction-a-hybrid-option-for-patients-with-ischemic-cardiomyopathy
#20
Christoph Schmitz, Mauri Biffi, Horst Sievert, Petr Neuzil, Salvatore Brugaletta, Christian Frerker, Azfar Zaman, Luigi Fiocca, Louis Labrousse, Lon Annest
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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