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micro needles

Anne Küntzel, Peter Oertel, Sina Fischer, Andreas Bergmann, Phillip Trefz, Jochen Schubert, Wolfram Miekisch, Petra Reinhold, Heike Köhler
BACKGROUND: Species of Mycobacteriaceae cause serious zoonotic diseases in mammals, for example tuberculosis in humans, dogs, parrots, and elephants (caused by Mycobacterium tuberculosis) and in ruminants and humans (caused by M. bovis and M. caprae). Pulmonary diseases, lymphadenitis, skin diseases, and disseminated diseases can be caused by non-tuberculous mycobacteria (NTM). Diagnosis and differentiation among Mycobacterium species are currently done by culture isolation. The established diagnostic protocols comprise several steps that allow species identification...
2018: PloS One
Steven V Beekmans, Kaj S Emanuel, Theodoor H Smit, Davide Iannuzzi
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 15, 2018: Scientific Reports
Casper G Thorpe Lowis, Zhaoyang Xu, Ming Zhang
Objectives: The size and shape of a joint cavity are the key determinates for the mobility of the joint. The anatomy and configuration of the facet joint (FJ) recesses at different levels of the spine remain unclear and controversial. The aim of this study was to identify the configuration of the FJ recesses in the cervical, thoracic and lumbar spine using a combination of micro-CT and sheet plastination techniques. Methods: Of 19 cadavers (9 males, 10 females, age range of 54-89 years), the FJ cavities of 3 spines were injected with contrast filling and scanned with micro-CT, and 16 plastinated spines were prepared as the series of sagittal (9 sets), transverse (5 sets) or coronal (2 sets) sections with a thickness of 2...
2018: BMJ Open Sport & Exercise Medicine
Omer Basar, Osman Yuksel, Dennis Yang, Jason Samarasena, David Forcione, Christopher J DiMaio, Mihir S Wagh, Kenneth Chang, Brenna Casey, Carlos Fernandez-Del Castillo, Martha B Pitman, William R Brugge
BACKGROUND AND AIM: The tissue acquisition and diagnostic yield of cyst fluid cytology is low-to-moderate and rarely provides a specific diagnosis. The aim of this study was to compare the tissue acquisition and diagnostic tissue yield of micro-forceps biopsy (MFB) with cyst fluid cytology. PATIENTS AND METHODS: The data of 42 patients, whose cysts were aspirated by EUS-guided fine needle aspiration (EUS-FNA) and then biopsied with MFB device in this multicenter study, were collected...
March 3, 2018: Gastrointestinal Endoscopy
Kehua Jiang, Hongbo Chen, Xiao Yu, Zhiqiang Chen, Zhangqun Ye, Huixing Yuan
The objectives of the study are to compare the safety and efficacy of "all-seeing needle" optical puncture system micro-percutaneous nephrolithotomy (micro-PCNL) and flexible ureterorenoscopy (FURS) for the treatment of lower calyceal stones of ≤ 2 cm and to determine the advantages and disadvantages of each. 116 patients in total with lower calyceal stones of ≤ 2 cm were randomly divided into two equal groups, "all-seeing needle" optical puncture system micro-PCNL and FURS. In both groups, holmium laser was utilized for lithotripsy...
March 1, 2018: Urolithiasis
Peter D Hebbard, Andrew I T Hebbard, Janos Tomka, Richard Appleyard
Ultrasound (US)-guided microinvasive procedures are defined as those performed via needles without notable scarring. Ten cadaver hands underwent US-guided microinvasive carpal tunnel release using a novel needle-based tool, the micro i-Blade (Summit Medical Products, Inc, Sandy, UT). A US-imaged landmark, the inflexion point of the ligaments distal to the hook of the hamate, was used to position the distal extent of the cut. The transverse carpal ligament was successfully released in all hands without damage to nerves or arteries...
February 16, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Ying Wan, John M Hickey, Christopher Bird, Katey Witham, Paul Fahey, Angus Forster, Sangeeta B Joshi, David B Volkin
The worldwide switch to inactivated polio vaccines (IPV) is a key component of the overall strategy to achieve and maintain global polio eradication. To this end, new IPV vaccine delivery systems may enhance patient convenience and compliance. In this work, we examine NanopatchTM (a solid, polymer micro-projection array) which offers potential advantages over standard needle/syringe administration including intradermal delivery and reduced antigen doses. Using trivalent IPV (tIPV) and a purpose-built evaporative dry-down system, candidate tIPV formulations were developed to stabilize tIPV during the drying process and upon storage...
February 5, 2018: Journal of Pharmaceutical Sciences
Franz J Söbbeler, Sabine Br Kästner
OBJECTIVE: To evaluate the transdermal local anaesthetic effect of lidocaine or lidocaine combined with prilocaine or tetracaine in horses. STUDY DESIGN: Experimental, randomized study. ANIMALS: A total of five healthy adult warmblood horses. METHODS: Horses were clipped bilaterally at the withers, cranial saddle area and caudal saddle area. Baseline measurements for mechanical superficial sensation via von Frey filaments and nociceptive thermal thresholds were performed...
December 2, 2017: Veterinary Anaesthesia and Analgesia
Yueh-Ling Hsieh, Ming-Ta Lin, Chang-Zern Hong, Hsin-Shui Chen
BACKGROUND: This study investigated the effects of percutaneous soft tissue release (PSTR) performed using a blunt cannula on (1) the inflammatory cells-count, (2) expressions of calcitonin gene-related peptide (CGRP) and (3) substance P (SP) in rabbits with chronic phase of collagenase-induced Achilles tendinopathy. METHODS: Thirty-two adult male New Zealand rabbits were randomly divided into four groups: (1) collagenase and PSTR treatment; (2) collagenase and sham-operated PSTR treatment; (3) vehicle-only injection and PSTR treatment; and (4) vehicle-only injection and sham-operated PSTR treatment...
October 29, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Bivek Chaulagain, Ankit Jain, Ankita Tiwari, Amit Verma, Sanjay K Jain
Skin is the largest external organ in the human body but its use for therapeutic purposes has been minimal. Stratum corneum residing on the uppermost layer of the skin provides a tough barrier to transport the drugs across the skin. Very small group of drugs sharing Lipinski properties, i.e. drugs having molecular weight not larger than 500 Da, having high lipophilicity and optimum polarity are fortunate enough to be used on skin therapeutics. But, at a time where modern therapeutics is slowly shifting from use of small molecular drugs towards the use of macromolecular therapeutic agents such as peptides, proteins and nucleotides in origin, skin therapeutics need to be evolved accordingly to cater the delivery of these agents...
January 29, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Chandra Has, Sopan M Phapal, P Sunthar
Laboratory preparation of unilamellar liposomes often involves multiple steps carried out over several hours to achieve a monodisperse size distribution. Here we present a methodology, based on a recently introduced lipid self-assembly principle-stationary phase interdiffusion (SPI)-to prepare large unilamellar vesicles (LUVs) of a monodisperse population in a short period of about 10min. The stationary interface between a lipid-ethanol phase and an aqueous phase is created by a density difference induced convective flow in a horizontal capillary...
January 17, 2018: Chemistry and Physics of Lipids
Yong Liu, Wei Mei
No abstract text is available yet for this article.
January 12, 2018: Anesthesiology
Andrew J Shoffstall, Suraj Srinivasan, Mitchell Willis, Allison M Stiller, Melanie Ecker, Walter E Voit, Joseph J Pancrazio, Jeffrey R Capadona
Mosquitos are among the deadliest insects on the planet due to their ability to transmit diseases like malaria through their bite. In order to bite, a mosquito must insert a set of micro-sized needles through the skin to reach vascular structures. The mosquito uses a combination of mechanisms including an insertion guide to enable it to bite and feed off of larger animals. Here, we report on a biomimetic strategy inspired by the mosquito insertion guide to enable the implantation of intracortical microelectrodes into the brain...
January 9, 2018: Scientific Reports
Alexander I Son, Justin D Opfermann, Caroline McCue, Julie Ziobro, John H Abrahams, Katherine Jones, Paul D Morton, Seiji Ishii, Chima Oluigbo, Axel Krieger, Judy S Liu, Kazue Hashimoto-Torii, Masaaki Torii
Local and controlled delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment of diseases that require direct interventions. However, current options are obtrusive, difficult to implement, and limited in their scope of utilization; the optimal solution requires a method that may be optimized for available therapies and is designed for exact delivery. To address these needs, we propose the Biocage, a customizable implantable local drug delivery platform. The device is a needle-sized porous container capable of encasing therapeutic molecules and matrices of interest to be eluted into the region of interest over time...
December 15, 2017: Scientific Reports
Amit Ritter, Gideon Bachar, Dania Hirsch, Carlos Benbassat, Orna Katz, Nadav Kochen, Talia Diker-Cohen, Amit Akirov, Ilan Shimon, Eyal Robenshtok
Background: Bilateral thyroid nodularity is considered an indication for total thyroidectomy in papillary thyroid carcinoma (PTC) patients. However, the natural history and outcome of contralateral nodules has never been studied. Objective: To investigate the natural history of non-suspicious contralateral nodules after lobectomy for PTC. Methods: We included patients who had ≥1 solid nodules (≥3mm) in the contralateral lobe prior to surgery with benign cytology, or small non suspicious nodules per ultrasound...
December 12, 2017: Journal of Clinical Endocrinology and Metabolism
Ann-Christin Bischoff, Peter Oertel, Pritam Sukul, Christian Rimmbach, Robert David, Jochen Schubert, Wolfram Miekisch
Bacterial and cell cultures are known to emit a large number of volatile organic compounds (VOCs). Conventional biochemical methods are often destructive, time-consuming and expensive. In contrast, VOC analysis of headspace over cultures may offer a non-destructive alternative for the monitoring of cell proliferation and metabolism. VOC profiles from cultures of murine pluripotent stem cells and fibroblasts were assessed every 24 h for 3 days. Pure cell media were measured as parallel controls. VOC analysis was highly standardized with respect to time of measurement and phases of cell growth...
March 1, 2018: Journal of Breath Research
Alina Vladescu, Diana M Vranceanu, Slawek Kulesza, Alexey N Ivanov, Mirosław Bramowicz, Alexander S Fedonnikov, Mariana Braic, Igor A Norkin, Andrey Koptyug, Maria O Kurtukova, Mihaela Dinu, Iulian Pana, Maria A Surmeneva, Roman A Surmenev, Cosmin M Cotrut
Properties of the hydroxyapatite obtained by electrochemical assisted deposition (ED) are dependent on several factors including deposition temperature, electrolyte pH and concentrations, applied potential. All of these factors directly influence the morphology, stoichiometry, crystallinity, electrochemical behaviour, and particularly the coating thickness. Coating structure together with surface micro- and nano-scale topography significantly influence early stages of the implant bio-integration. The aim of this study is to analyse the effect of pH modification on the morphology, corrosion behaviour and in vitro bioactivity and in vivo biocompatibility of hydroxyapatite prepared by ED on the additively manufactured Ti64 samples...
December 1, 2017: Scientific Reports
Tao Sun, Qing Shi, Qiang Huang, Huaping Wang, Xiaolu Xiong, Chengzhi Hu, Toshio Fukuda
Traditional cell-encapsulating scaffolds may elicit adverse host responses and inhomogeneity in cellular distribution. Thus, fabrication techniques for cellular self-assembly with micro-scaffold incorporation have been used recently to generate toroidal cellular modules for the bottom-up construction of vascular-like structures. The micro-scaffolds show advantage in promoting tissue formation. However, owing to the lack of annular cell micro-scaffolds, it remains a challenge to engineer micro-scale toroidal cellular modules (micro-TCMs) to fabricate microvascular-like structures...
January 15, 2018: Acta Biomaterialia
H H Kwon, H Y Park, S C Choi, Y Bae, J Y Jung, G-H Park
BACKGROUND: While device-based acne treatments are widely applied for patients not tolerating conventional medications, related controlled studies have been still limited. Recently, non-ablative 1450-nm diode laser (DL) and fractional microneedling radiofrequency (FMR) have been effectively used for acne, in addition to well-recognized dermal remodelling effects. OBJECTIVE: To compare the clinical course of acne treatment between DL and FMR. METHODS: Twenty-five Korean patients with mild-to-moderate facial acne completed treatments with DL and FMR through a 20-week, randomized split-face study...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
Koen van der Maaden, Jeroen Heuts, Marcel Camps, Maria Pontier, Anton Terwisscha van Scheltinga, Wim Jiskoot, Ferry Ossendorp, Joke Bouwstra
Recent studies have shown that intradermal vaccination has great potential for T cell-mediated cancer immunotherapy. However, classical intradermal immunization with a hypodermic needle and syringe has several drawbacks. Therefore, in the present study a digitally controlled hollow microneedle injection system (DC-hMN-iSystem) with an ultra-low dead volume was developed to perform micro-injections (0.25-10μL) into skin in an automated manner. A synthetic long peptide derived from human papilloma virus formulated in cationic liposomes, which was used as a therapeutic cancer vaccine, was administered intradermally by using the DC-hMN-iSystem...
January 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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