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https://www.readbyqxmd.com/read/29324482/enhanced-needle-visibility-by-micro-air-bubble-contrast-in-ultrasound-guided-nerve-block
#1
Yong Liu, Wei Mei
No abstract text is available yet for this article.
January 12, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29317748/a-mosquito-inspired-strategy-to-implant-microprobes-into-the-brain
#2
Andrew J Shoffstall, Suraj Srinivasan, Mitchell Willis, Allison M Stiller, Melanie Ecker, Walter E Voit, Joseph J Pancrazio, Jeffrey R Capadona
Mosquitos are among the deadliest insects on the planet due to their ability to transmit diseases like malaria through their bite. In order to bite, a mosquito must insert a set of micro-sized needles through the skin to reach vascular structures. The mosquito uses a combination of mechanisms including an insertion guide to enable it to bite and feed off of larger animals. Here, we report on a biomimetic strategy inspired by the mosquito insertion guide to enable the implantation of intracortical microelectrodes into the brain...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29247175/an-implantable-micro-caged-device-for-direct-local-delivery-of-agents
#3
Alexander I Son, Justin D Opfermann, Caroline McCue, Julie Ziobro, John H Abrahams, Katherine Jones, Paul D Morton, Seiji Ishii, Chima Oluigbo, Axel Krieger, Judy S Liu, Kazue Hashimoto-Torii, Masaaki Torii
Local and controlled delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment of diseases that require direct interventions. However, current options are obtrusive, difficult to implement, and limited in their scope of utilization; the optimal solution requires a method that may be optimized for available therapies and is designed for exact delivery. To address these needs, we propose the Biocage, a customizable implantable local drug delivery platform. The device is a needle-sized porous container capable of encasing therapeutic molecules and matrices of interest to be eluted into the region of interest over time...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29240898/natural-history-of-contralateral-nodules-after-lobectomy-in-patients-with-papillary-thyroid-carcinoma
#4
Amit Ritter, Gideon Bachar, Dania Hirsch, Carlos Benbassat, Orna Katz, Nadav Kochen, Talia Diker-Cohen, Amit Akirov, Ilan Shimon, Eyal Robenshtok
Background: Bilateral thyroid nodularity is considered an indication for total thyroidectomy in papillary thyroid carcinoma (PTC) patients. However, the natural history and outcome of contralateral nodules has never been studied. Objective: To investigate the natural history of non-suspicious contralateral nodules after lobectomy for PTC. Methods: We included patients who had ≥1 solid nodules (≥3mm) in the contralateral lobe prior to surgery with benign cytology, or small non suspicious nodules per ultrasound...
December 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29231842/smell-of-cells-volatile-profiling-of-stem-and-non-stem-cell-proliferation
#5
Ann-Christin Bischoff, Peter Oertel, Pritam Sukul, Christian Rimmbach, Robert David, Jochen Schubert, Wolfram Miekisch
Bacterial and cell cultures are known to emit a large number of volatile organic compounds (VOCs). Conventional biochemical methods are often destructive, time-consuming and ex-pensive. In contrast, VOC analysis of headspace over cultures, may offer a non-destructive alternative to monitor cell proliferation and metabolism. VOC profiles from cultures of murine pluripotent stem cells and fibroblasts were assessed every 24 hours for 3 days. Pure cell media were measured as parallel controls. VOC analysis was highly standardized with respect to time of measurement and phases of cell growth...
December 12, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29196637/influence-of-the-electrolyte-s-ph-on-the-properties-of-electrochemically-deposited-hydroxyapatite-coating-on-additively-manufactured-ti64-alloy
#6
Alina Vladescu, Diana M Vranceanu, Slawek Kulesza, Alexey N Ivanov, Mirosław Bramowicz, Alexander S Fedonnikov, Mariana Braic, Igor A Norkin, Andrey Koptyug, Maria O Kurtukova, Mihaela Dinu, Iulian Pana, Maria A Surmeneva, Roman A Surmenev, Cosmin M Cotrut
Properties of the hydroxyapatite obtained by electrochemical assisted deposition (ED) are dependent on several factors including deposition temperature, electrolyte pH and concentrations, applied potential. All of these factors directly influence the morphology, stoichiometry, crystallinity, electrochemical behaviour, and particularly the coating thickness. Coating structure together with surface micro- and nano-scale topography significantly influence early stages of the implant bio-integration. The aim of this study is to analyse the effect of pH modification on the morphology, corrosion behaviour and in vitro bioactivity and in vivo biocompatibility of hydroxyapatite prepared by ED on the additively manufactured Ti64 samples...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29196117/magnetic-alginate-microfibers-as-scaffolding-elements-for-the-fabrication-of-microvascular-like-structures
#7
Tao Sun, Qing Shi, Qiang Huang, Huaping Wang, Xiaolu Xiong, Chengzhi Hu, Toshio Fukuda
Traditional cell-encapsulating scaffolds may elicit adverse host responses and inhomogeneity in cellular distribution. Thus, fabrication techniques for cellular self-assembly with micro-scaffold incorporation have been used recently to generate toroidal cellular modules for the bottom-up construction of vascular-like structures. The micro-scaffolds show advantage in promoting tissue formation. However, owing to the lack of annular cell micro-scaffolds, it remains a challenge to engineer micro-scale toroidal cellular modules (micro-TCMs) to fabricate microvascular-like structures...
November 28, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29178495/novel-device-based-acne-treatments-comparison-of-a-1450-nm-diode-laser-and-microneedling-radiofrequency-on-mild-to-moderate-acne-vulgaris-and-seborrhoea-in-korean-patients-through-a-20-week-prospective-randomized-split-face-study
#8
H H Kwon, H Y Park, S C Choi, Y Bae, J Y Jung, G-H Park
BACKGROUND: While device-based acne treatments are widely applied for patients not tolerating conventional medications, related controlled studies have been still limited. Recently, non-ablative 1450-nm diode laser (DL) and fractional microneedling radiofrequency (FMR) have been effectively used for acne, in addition to well-recognized dermal remodelling effects. OBJECTIVE: To compare the clinical course of acne treatment between DL and FMR. METHODS: Twenty-five Korean patients with mild-to-moderate facial acne completed treatments with DL and FMR through a 20-week, randomized split-face study...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29174441/hollow-microneedle-mediated-micro-injections-of-a-liposomal-hpv-e743-63-synthetic-long-peptide-vaccine-for-efficient-induction-of-cytotoxic-and-t-helper-responses
#9
Koen van der Maaden, Jeroen Heuts, Marcel Camps, Maria Pontier, Anton Terwisscha van Scheltinga, Wim Jiskoot, Ferry Ossendorp, Joke Bouwstra
Recent studies have shown that intradermal vaccination has great potential for T cell-mediated cancer immunotherapy. However, classical intradermal immunization with a hypodermic needle and syringe has several drawbacks. Therefore, in the present study a digitally controlled hollow microneedle injection system (DC-hMN-iSystem) with an ultra-low dead volume was developed to perform micro-injections (0.25-10μL) into skin in an automated manner. A synthetic long peptide derived from human papilloma virus formulated in cationic liposomes, which was used as a therapeutic cancer vaccine, was administered intradermally by using the DC-hMN-iSystem...
November 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29168711/separation-of-emulsified-crude-oil-in-saline-water-by-flotation-with-micro-and-nanobubbles-generated-by-a-multiphase-pump
#10
H A Oliveira, A C Azevedo, R Etchepare, J Rubio
The flocculation-column flotation with hydraulic loading (HL, >10 m h(-1)) was studied for the treatment of oil-in-water emulsions containing 70-400 mg L(-1) (turbidity = 70-226 NTU) of oil and salinity (30 and 100 g L(-1)). A polyacrylamide (Dismulgan, 20 mg L(-1)) flocculated the oil droplets, using two floc generator reactors, with rapid and slow mixing stages (head loss = 0.9 to 3.5 bar). Flotation was conducted in two cells (1.5 and 2.5 m) with microbubbles (MBs, 5-80 μm) and nanobubbles (NBs, 50-300 nm diameter, concentration of 10(8) NBs mL(-1))...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29140298/enhancement-of-bone-marrow-derived-mesenchymal-stem-cell-osteogenesis-and-new-bone-formation-in-rats-by-obtusilactone-a
#11
Yi-Hsiung Lin, Chung-Yi Chen, Liang-Yin Chou, Chung-Hwan Chen, Lin Kang, Chau-Zen Wang
The natural pure compound obtusilactone A (OA) was identified in Cinnamomum kotoense Kanehira & Sasaki, and shows effective anti-cancer activity. We studied the effect of OA on osteogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). OA possesses biocompatibility, stimulates Alkaline Phosphatase (ALP) activity and facilitates mineralization of BMSCs. Expression of osteogenesis markers BMP2, Runx2, Collagen I, and Osteocalcin was enhanced in OA-treated BMSCs. An in vivo rat model with local administration of OA via needle implantation to bone marrow-residing BMSCs revealed that OA increased the new bone formation and trabecular bone volume in tibias...
November 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29097106/3d-axon-growth-by-exogenous-electrical-stimulus-and-soluble-factors
#12
Min D Tang-Schomer
Axon growth and alignment are fundamental processes during nervous system development and neural regeneration after injury. The present study investigates the effects of exogenous stimulus of electrical signals and soluble factors on axon 3D growth, using a silk protein material-based 3D brain tissue model. Electrical stimulus was delivered via embedded gold wires positioned at the interface of the scaffold region and the center matrix gel-filled region, spanning the axon growth area. This setup delivered applied electrical field directly to growing axons, and the effects were compared to micro-needle assisted local delivery of soluble factors of extracellular (ECM) components and neurotrophins...
October 30, 2017: Brain Research
https://www.readbyqxmd.com/read/29095635/optical-contactless-measurement-of-electric-field-induced-tensile-stress-in-diamond-nanoscale-needles
#13
L Rigutti, L Venturi, J Houard, A Normand, E P Silaeva, M Borz, S A Malykhin, A N Obraztsov, A Vella
The application of a high electrostatic field at the apex of monocrystalline diamond nanoscale needles induces an energy splitting of the photoluminescence lines of color centers. In particular, the splitting of the zero-phonon line of the neutral nitrogen-vacancy complex (NV(0)) has been studied within a laser-assisted tomographic atom probe equipped with an in situ microphotoluminescence bench. The measured quadratic dependence of the energy splitting on the applied voltage corresponds to the stress generated on the metal-like apex surface by the electrostatic field...
November 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/29074201/safety-acceptability-and-tolerability-of-uncoated-and-excipient-coated-high-density-silicon-micro-projection-array-patches-in-human-subjects
#14
Paul Griffin, Suzanne Elliott, Kenia Krauer, Cristyn Davies, S Rachel Skinner, Christopher D Anderson, Angus Forster
Most vaccinations are performed by intramuscular injection with a needle and syringe. However, this method is not ideal due to limitations, such as the risk of needle-stick injury, the requirement for trained personnel to give injections and the need to reconstitute lyophilized vaccines. Therefore, we tested an alternative delivery technology that overcomes the problems with needle and syringe. The Nanopatch™ is an array of 10,000 silicon micro-projections per cm(2) that can be dry-coated with vaccine for skin delivery...
October 23, 2017: Vaccine
https://www.readbyqxmd.com/read/29066492/granulomatous-thyroiditis-a-case-report-and-literature-review
#15
Darshan P Trivedi, Ramesh Bhagat, Yukihiro Nakanishi, Alun Wang, Krzysztof Moroz, Nadja K Falk
BACKGROUND: Granulomatous disease in the thyroid gland has been linked to viral, bacterial and autoimmune etiologies. The most common granulomatous disease of the thyroid is subacute granulomatous thyroiditis, which is presumed to have a viral or post-viral inflammatory cause. Bacterial etiologies include tuberculosis, actinomycosis, and nocardiosis, but are extremely rare. Disseminated actinomycosis and nocardiosis more commonly affect organ-transplant patients with the highest susceptibility within the first year after transplant surgery...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29063297/pre-operative-axillary-ultrasound-guided-needle-sampling-in-breast-cancer-comparing-the-sensitivity-of-fine-needle-aspiration-cytology-and-core-needle-biopsy
#16
Ashley R Topps, Simon P Barr, Panagiotis Pikoulas, Susan A Pritchard, Anthony J Maxwell
BACKGROUND: Pre-operative ultrasound-guided needle sampling (UNS) of abnormal axillary lymph nodes in breast cancer can identify patients with axillary metastases and therefore rationalize patient care and inform decision-making. To obtain tissue diagnosis, UNS can be performed by either fine needle aspiration (FNA) or core needle biopsy (CNB). However, few studies have compared the sensitivity of these techniques and the majority show no difference. METHODS: All node-positive patients (those with micro- and macrometastases but not isolated tumor cells) treated at a tertiary referral center between January 2012 and December 2015 were retrospectively identified from pathology records...
October 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29058788/significant-skin-tightening-by-closure-of-fractional-ablative-laser-holes
#17
Elisabeth Russe, Martin Purschke, Wikunda Limpiangkanan, William A Farinelli, Ying Wang, Apostolos G Doukas, Fernanda H Sakamoto, Gottfried Wechselberger, Richard Rox Anderson
BACKGROUND AND OBJECTIVE: Ablative fractional laser treatment uses thousands of very small laser beam wounds to damage a fraction of the skin, which stimulates tissue remodeling. Each open micro-wound heals without scarring, but the amount of skin tightening achieved is limited. This animal study was performed to test the hypothesis that immediate temporary closure of fractional laser wounds could increase skin tightening after fractional ablative laser treatment. MATERIALS AND METHODS: Four adult swine were used for the study; 98 square test sites (3 × 3 cm) were tattooed on the abdomen and flanks of each pig...
October 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29056444/long-lived-tissue-resident-hiv-1-specific-memory-cd8-t-cells-are-generated-by-skin-immunization-with-live-virus-vectored-microneedle-arrays
#18
Marija Zaric, Pablo Daniel Becker, Catherine Hervouet, Petya Kalcheva, Barbara Ibarzo Yus, Clement Cocita, Lauren Alexandra O'Neill, Sung-Yun Kwon, Linda Sylvia Klavinskis
The generation of tissue resident memory (TRM) cells at the body surfaces to provide a front line defence against invading pathogens represents an important goal in vaccine development for a wide variety of pathogens. It has been widely assumed that local vaccine delivery to the mucosae is necessary to achieve that aim. Here we characterise a novel micro-needle array (MA) delivery system fabricated to deliver a live recombinant human adenovirus type 5 vaccine vector (AdHu5) encoding HIV-1 gag. We demonstrate rapid dissolution kinetics of the microneedles in skin...
October 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29052557/determination-of-volatile-organic-compounds-in-exhaled-breath-of-heart-failure-patients-by-needle-trap-micro-extraction-coupled-with-gas-chromatography-tandem-mass-spectrometry
#19
Denise Biagini, Tommaso Lomonaco, Silvia Ghimenti, Francesca Giuseppa Bellagambi, Massimo Onor, Maria Chiara Scali, Valentina Barletta, Mario Marzilli, Pietro Salvo, Maria Giovanna Trivella, Roger Fuoco, Fabio Di Francesco
The analytical performances of needle trap micro-extraction (NTME) coupled with gas chromatography tandem mass spectrometry were evaluated by analyzing a mixture of twenty-two representative breath VOCs belonging to different chemical classes (i.e. hydrocarbons, ketones, aldehydes, aromatics and sulfurs). NTME is an emerging technique that guarantees detection limits in pptv range by pre-concentrating low volumes of sample, and it is particularly suitable for breath analysis. For most VOCs, detection limits between 20 and 500 pptv were obtained by pre-concentrating 25 mL of a humidified standard gas mixture at a flow rate of 15 mL/min...
October 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29037893/gelatin-promotes-rapid-restoration-of-the-blood-brain-barrier-after-acute-brain-injury
#20
Lucas S Kumosa, Valdemar Zetterberg, Jens Schouenborg
Gelatin coating of brain implants is known to provide considerable benefits in terms of reduced inflammatory sequalae and long-term neuroprotective effects. However, the mechanisms for gelatin's protective role in brain injury are still unknown. To address this question, cellular and molecular markers were studied with quantitative immunohistochemical microscopy at acute (<2hours, 1, 3days), intermediate (1-2 weeks) and long-term time points (6 weeks) after transient insertion of stainless steel needles into female rat cortex cerebri with or without gelatin coating...
October 14, 2017: Acta Biomaterialia
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