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https://www.readbyqxmd.com/read/28628624/heterogeneity-of-mirna-expression-in-localized-prostate-cancer-with-clinicopathological-correlations
#1
Ahmed Hussein Zedan, Søren Garm Blavnsfeldt, Torben Frøstrup Hansen, Boye Schnack Nielsen, Niels Marcussen, Mindaugas Pleckaitis, Palle Jörn Sloth Osther, Flemming Brandt Sørensen
INTRODUCTION: In the last decade microRNAs (miRNAs) have been widely investigated in prostate cancer (PCa) and have shown to be promising biomarkers in diagnostic, prognostic and predictive settings. However, tumor heterogeneity may influence miRNA expression. The aims of this study were to assess the impact of tumor heterogeneity, as demonstrated by a panel of selected miRNAs in PCa, and to correlate miRNA expression with risk profile and patient outcome. MATERIAL AND METHODS: Prostatectomy specimens and matched, preoperative needle biopsies from a retrospective cohort of 49 patients, who underwent curatively intended surgery for localized PCa, were investigated with a panel of 6 miRNAs (miRNA-21, miRNA-34a, miRNA-125b, miRNA-126, miRNA-143, and miRNA-145) using tissue micro-array (TMA) and in situ hybridization (ISH)...
2017: PloS One
https://www.readbyqxmd.com/read/28622807/the-comparison-of-the-effects-of-a-novel-hydrogel-compound-and-traditional-hyaluronate-following-micro-fracture-procedure-in-a-rat-full-thickness-chondral-defect-model
#2
Yunus Emre Akman, Erhan Sukur, Ahmet Senel, Nur Ece Oztas Sukur, Canan Kelten Talu, Yusuf Ozturkmen
PURPOSE: The aim of this experimental study was to investigate the impact of HA-CS-NAG compound (hyaluronate, sodium chondroitin sulfate, N-acetyl-d-glucosamine) on the quality of repair tissue after micro-fracture and to compare it with HA (hyaluronat), in a rat full-thickness chondral defect model. METHODS: Full-thickness chondral defects were created in a non-weight bearing area by using a handle 2.7-mm drill bit, in the right knees of 33 Sprague-Dawley rats...
June 13, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28622082/comparing-the-effectiveness-of-fractional-co2-laser-and-the-combination-therapy-with-micro-needling-and-topical-10-trichloroacetic-acid-to-remove-infra-orbital-dark-circles-in-tehran-women
#3
Abbas Zamanian, Mahba Azizi, Mohamadreza Ghasemi, Elham Behrangi, Sedigheh Naeji
BACKGROUND: Infra-orbital dark circles in now identified as a cosmetic problem which should be considered in treatment issue. The present study aimed to assess and compare the clinical efficiency of the combination of micro-needling and 10% trichloroacetic acid (TCA) cream as well as carbon dioxide laser in the management of infra-orbital dark circles. METHODS: This randomized clinical trial was performed on women ranged 28 to 62 years that complained of infra-orbital dark circles...
June 16, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28618219/hierarchical-microspheres-constructed-from-chitin-nanofibers-penetrated-hydroxyapatite-crystals-for-bone-regeneration
#4
Bo Duan, Kangquan Shou, Xiaojuan Su, Yahui Niu, Guan Zheng, Yao Huang, Ai-Xi Yu, Yu Zhang, Hong Xia, Lina Zhang
Chitin exists abundantly in the crab and shrimp shell as the template of the minerals, which inspired us to mineralize it for fabricating the bone grafting materials. In present work, chitin nanofibrous microspheres were used as the matrix for in situ synthesisof the hydroxyapatite (HA) crystals including micro-flake, submicron-needle and submicron-osphere, which were penetrated by long chitin nanofibers, leading to the hierarchical structure. The shape and size of the HA crystals could be controled by changing the HA synthesisprocess...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28605376/anatomically-inspired-three-dimensional-micro-tissue-engineered-neural-networks-for-nervous-system-reconstruction-modulation-and-modeling
#5
Laura A Struzyna, Dayo O Adewole, Wisberty J Gordián-Vélez, Michael R Grovola, Justin C Burrell, Kritika S Katiyar, Dmitriy Petrov, James P Harris, D Kacy Cullen
Functional recovery rarely occurs following injury or disease-induced degeneration within the central nervous system (CNS) due to the inhibitory environment and the limited capacity for neurogenesis. We are developing a strategy to simultaneously address neuronal and axonal pathway loss within the damaged CNS. This manuscript presents the fabrication protocol for micro-tissue engineered neural networks (micro-TENNs), implantable constructs consisting of neurons and aligned axonal tracts spanning the extracellular matrix (ECM) lumen of a preformed hydrogel cylinder hundreds of microns in diameter that may extend centimeters in length...
May 31, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28586592/ultrasound-assistance-in-differentiating-malignant-thyroid-nodules-from-benign-ones
#6
Shokouh Taghipour Zahir, Mahmoud Vakili, Azam Ghaneei, Naser Sefidrokh Sharahjin, Fatemeh Heidari
OBJECTIVE: The search is ongoing for simple, effective ways to identify and differentiate thyroid nodules in order to avoid invasive procedures. This study aims to perform an ultrasound assessment of clinically suspected patients with malignant nodules, to perform a fine needle biopsy on them, and to compare the results obtained. METHODS: In total, 135 patients with thyroid nodules suspected to be malignant in the ultrasound underwent ultrasound-guided fine needle biopsies...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28548491/deposition-of-a-sorbent-into-a-recession-on-a-solid-support-provides-a-new-mechanically-robust-solid-phase-micro-extraction-device
#7
Justen J Poole, Jonathan J Grandy, Miao Yu, Ezel Boyaci, German A Gomez Rios, Nathaly Reyes-Garcés, Barbara Bojko, Harmen Vander Heide, Janusz Pawliszyn
To date, solid-phase microextraction (SPME) fibers used for in-vivo bio-analysis can be too fragile and flexible, which limits suitability for direct tissue sampling. As a result, these devices often require a sheathing needle to pre-puncture robust sample matrices and protect the extraction phase from mechanical damage. To address this limitation, a new SPME device is herein presented which incorporates an extraction phase recessed into the body of a solid needle. This device requires no additional support or shielding during puncture events through protective tissue...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28515437/coco3-from-one-step-micro-emulsion-method-as-electrode-materials-for-faradaic-capacitors
#8
Yanfang Wang, Zheng Chang, Yi Zhang, Bingwei Chen, Lijun Fu, Yusong Zhu, Lixin Zhang, Yuping Wu
Faradaic capacitor (FC) has been widely investigated during the past few decades, and dozens of prototypes have been proposed. However, it has not reached its full potential. In this work, we demonstrate a kind of FC comprising of a CoCO3 electrode. Synthesized through a micro-emulsion route, such CoCO3 shows low crystallinity and porous wool-ball structures stacked by needle-like individuals. It shows desirable electrochemical properties in terms of excellent high-rate performance and high reversibility. Also, it could deliver a capacitance of 440 F·g(-1) at 1 A·g(-1), and shows no capacitance decay after 1000 cycles...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28512669/combined-fractional-treatment-of-acne-scars-involving-non-ablative-1-550-nm-erbium-glass-laser-and-micro-needling-radiofrequency-a-16-week-prospective-randomized-split-face-study
#9
Hyuck Hoon Kwon, Hae Young Park, Sun Chul Choi, Youin Bae, Chanhee Kang, Jae Yoon Jung, Gyeong-Hun Park
An optimized therapeutic regimen involving a non-ablative fractionated laser or radiofrequency therapy for acne scars has not yet been established. To evaluate whether the combination of a non-ablative fractional laser (NAF) and fractional micro-needling radiofrequency (FMR) has clinical advantages for the treatment of atrophic acne scars compared with NAF alone, a 16-week prospective, randomized split-face study was performed. Each facial side of a patient was treated with 3 sessions of either NAF with FMR or NAF alone, with a 4-week interval between each session...
May 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28482516/centrifugally-spun-phbv-micro-and-nanofibres
#10
Sarah J Upson, Tom O'Haire, Stephen J Russell, Kenneth Dalgarno, Ana Marina Ferreira
This paper reports the first study on centrifugal spinning of PHBV fibres. Fibres were spun from solution using a range of polymer concentrations, spin speeds and spinneret to collector distances. A PHBV polymer concentration of 25% w/v spun at 9000rmin(-1) produced the highest quality fibres, with fibre diameters predominantly in the 0.5-3μm range. The rate at which fibre could be produced at the 9000rmin(-1) spin speed and with a spinneret to collector distance of 39.2cm was equivalent to 11km of fibre per minute per needle...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28444564/response-to-lead-pollution-mycorrhizal-pinus-sylvestris-forms-the-biomineral-pyromorphite-in-roots-and-needles
#11
Maria L Bizo, Sandor Nietzsche, Ulrich Mansfeld, Falko Langenhorst, Juraj Majzlan, Jörg Göttlicher, Alexandru Ozunu, Steffi Formann, Katrin Krause, Erika Kothe
The development of mycorrhized pine seedlings grown in the presence of lead was assessed in order to investigate how higher plants can tolerate lead pollution in the environment. Examination with scanning electron microscopy (SEM) revealed that Pb uptake was prominent in the roots, while a smaller amount was found in pine needles, which requires symplastic uptake and root-to-shoot transfer. Lead was concentrated in nanocrystalline aggregates attached to the cell wall and, according to elemental microanalyses, is associated with phosphorus and chlorine...
April 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28439160/ranula-decompression-using-stitch-and-stab-method-the-aluko-technique
#12
Bayo Aluko-Olokun, Ademola Abayomi Olaitan
BACKGROUND: A ranula is a cystic lesion in the floor of the mouth, formed either as a retention cyst or pseudocyst as a result of extravasation of mucus in the surrounding tissue. It may be treated by micro-marsupialization, marsupialization or excision of lesion with or without the associated salivary gland. Marsupialization is usually achieved by cutting a slit and thereafter stitching the edges such that the epithelium of the exterior becomes continuous with that of the interior of a cyst...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28392646/the-effect-of-micro-spicule-containing-epidermal-growth-factor-on-periocular-wrinkles
#13
Jeong-Min Ha, Cho-Ah Lim, Kyuboem Han, Jong-Cheon Ha, Hae-Eul Lee, Young Lee, Young-Joon Seo, Chang-Deok Kim, Jeung-Hoon Lee, Myung Im
BACKGROUND: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort. OBJECTIVE: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles. METHODS: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study...
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28363548/in-situ-deposition-of-cu2o-micro-needles-for-biologically-active-textiles-and-their-release-properties
#14
Hossam E Emam, Hanan B Ahmed, Thomas Bechtold
Metal/metal oxide containing fibres are gradually increasing in textile industrialization recently, owing to their high potential for application as antimicrobial textiles. In this study, the reducing properties of cellulose were applied to synthesize cuprous oxide in-situ. The direct formation of Cu2O on viscose fabrics was achieved via quite simple technique in two subsequent steps: alkalization and sorption. Cu contents in fabrics before and after rinsing ranged between 45.2-86.4mmol/kg and 18.1-67.7mmol/kg, respectively...
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28355887/micro-to-nanoneedles-a-trend-of-modernized-transepidermal-drug-delivery-system
#15
Pravin Shende, Mrunmayi Sardesai, R S Gaud
The transdermal route of drug delivery is convenient, pain-free and follows controlled rate release pattern. However, many therapeutically active drugs cannot cross the stratum corneum effectively. Lipophilic drugs like nifedipine cross the outer skin barrier easily and polar drugs, such as epinephrine are ineffective in showing the same effect. Due to these reasons, advancements in drug delivery have taken place to deliver a wide range of drugs, especially macromolecules through the transdermal route and directly into systemic circulation bypassing hepatic metabolism and GIT degradation...
March 30, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28333174/response-to-commentaries-on-micro-needling-depth-penetration-presence-of-pigment-particles-and-fluorescein-stained-platelets-clinical-usage-for-aesthetic-concerns
#16
https://www.readbyqxmd.com/read/28326714/-effect-of-pinus-massoniana-needle-extract-on-root-dentin-demineralization-in-vitro
#17
Tang Chengfang, Ruan Jianping, Zhu Yong, Li Zixia, Zuo Yanping, Xu Hongyan
OBJECTIVE: This study aims to evaluate the effects of Pinus massoniana needle extract (PMNE) on inhibiting demineralization of root dentin. METHODS: Root dentin blocks were randomly divided into distilled deionized water (DDW) group, fluoride sodium (NaF) group, and 4%, 8% and 12% PMNE groups according to the experimental solution used in the process of pH cycling in each group. All specimens in each group experienced pH cycling for 8 d. The dentin mineral density (DMD) of the normal dentin and demineralized dentin and their D-value (ΔDMD) were determined using micro computed tomography...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28296143/targeting-the-safe-zone
#18
Andrea Mignatti, Patricia Friedmann, David Paul Slovut
OBJECTIVE: The aim of this study was to assess the effectiveness of a quality improvement (QI) program in reducing vascular complications during cardiac catheterization. BACKGROUND: Vascular access complications during cardiac catheterization are associated with higher morbidity and mortality. We implemented a QI program focused on using micropuncture techniques and targeting the "safe zone," an area below the inferior border of the inferior epigastric artery and above the inferior border of the femoral head, for femoral artery puncture...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28285075/thermally-triggered-hydrogel-injection-into-bovine-intervertebral-disc-tissue-explants-induces-differentiation-of-mesenchymal-stem-cells-and-restores-mechanical-function
#19
A A Thorpe, G Dougill, L Vickers, N D Reeves, C Sammon, G Cooper, C L Le Maitre
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6weeks...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28275513/extending-indications-of-micropercutaneous-nephrolithotomy-it-is-not-just-about-cracking-stones
#20
Arvind P Ganpule, Jaspreet Singh Chhabra, S B Sudharsan, Ankush Jairath, Mohankumar Vijaykumar, Ravindra Sabnis, Mahesh R Desai
OBJECTIVE: To describe our experience and results of using the MicroPerc™ micropercutaneous nephrolithotomy armamentarium (PolyDiagnost, Germany) for unusual indications unexplored using this modality. PATIENTS AND METHODS: We used the MicroPerc™ system for stone clearance in three ureteric calculi, two bladder calculi, one case of urethral calculus, for antegrade biopsy in a case of upper tract urothelial carcinoma, for Deflux® (dextranomer/hyaluronic copolymer, Salix Pharmaceuticals, Uppsala, Sweden) injection in three cases of vesico-ureteric reflux (VUR), and three cases of posterior urethral valve (PUV) fulgurations...
March 2017: Arab Journal of Urology
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