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https://www.readbyqxmd.com/read/29140298/enhancement-of-bone-marrow-derived-mesenchymal-stem-cell-osteogenesis-and-new-bone-formation-in-rats-by-obtusilactone-a
#1
Yi-Hsiung Lin, Chung-Yi Chen, Liang-Yin Chou, Chung-Hwan Chen, Lin Kang, Chau-Zen Wang
The natural pure compound obtusilactone A (OA) was identified in Cinnamomum kotoense Kanehira & Sasaki, and shows effective anti-cancer activity. We studied the effect of OA on osteogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). OA possesses biocompatibility, stimulates Alkaline Phosphatase (ALP) activity and facilitates mineralization of BMSCs. Expression of osteogenesis markers BMP2, Runx2, Collagen I, and Osteocalcin was enhanced in OA-treated BMSCs. An in vivo rat model with local administration of OA via needle implantation to bone marrow-residing BMSCs revealed that OA increased the new bone formation and trabecular bone volume in tibias...
November 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29097106/3d-axon-growth-by-exogenous-electrical-stimulus-and-soluble-factors
#2
Min D Tang-Schomer
Axon growth and alignment are fundamental processes during nervous system development and neural regeneration after injury. The present study investigates the effects of exogenous stimulus of electrical signals and soluble factors on axon 3D growth, using a silk protein material-based 3D brain tissue model. Electrical stimulus was delivered via embedded gold wires positioned at the interface of the scaffold region and the center matrix gel-filled region, spanning the axon growth area. This setup delivered applied electrical field directly to growing axons, and the effects were compared to micro-needle assisted local delivery of soluble factors of extracellular (ECM) components and neurotrophins...
October 30, 2017: Brain Research
https://www.readbyqxmd.com/read/29095635/optical-contactless-measurement-of-electric-field-induced-tensile-stress-in-diamond-nanoscale-needles
#3
L Rigutti, L Venturi, J Houard, A Normand, E P Silaeva, M Borz, S A Malykhin, A N Obraztsov, A Vella
The application of a high electrostatic field at the apex of monocrystalline diamond nanoscale needles induces an energy splitting of the photoluminescence lines of color centers. In particular, the splitting of the zero-phonon line of the neutral nitrogen-vacancy complex (NV(0)) has been studied within a laser-assisted tomographic atom probe equipped with an in situ microphotoluminescence bench. The measured quadratic dependence of the energy splitting on the applied voltage corresponds to the stress generated on the metal-like apex surface by the electrostatic field...
November 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/29074201/safety-acceptability-and-tolerability-of-uncoated-and-excipient-coated-high-density-silicon-micro-projection-array-patches-in-human-subjects
#4
Paul Griffin, Suzanne Elliott, Kenia Krauer, Cristyn Davies, S Rachel Skinner, Christopher D Anderson, Angus Forster
Most vaccinations are performed by intramuscular injection with a needle and syringe. However, this method is not ideal due to limitations, such as the risk of needle-stick injury, the requirement for trained personnel to give injections and the need to reconstitute lyophilized vaccines. Therefore, we tested an alternative delivery technology that overcomes the problems with needle and syringe. The Nanopatch™ is an array of 10,000 silicon micro-projections per cm(2) that can be dry-coated with vaccine for skin delivery...
October 23, 2017: Vaccine
https://www.readbyqxmd.com/read/29066492/granulomatous-thyroiditis-a-case-report-and-literature-review
#5
Darshan P Trivedi, Ramesh Bhagat, Yukihiro Nakanishi, Alun Wang, Krzysztof Moroz, Nadja K Falk
BACKGROUND: Granulomatous disease in the thyroid gland has been linked to viral, bacterial and autoimmune etiologies. The most common granulomatous disease of the thyroid is subacute granulomatous thyroiditis, which is presumed to have a viral or post-viral inflammatory cause. Bacterial etiologies include tuberculosis, actinomycosis, and nocardiosis, but are extremely rare. Disseminated actinomycosis and nocardiosis more commonly affect organ-transplant patients with the highest susceptibility within the first year after transplant surgery...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29063297/pre-operative-axillary-ultrasound-guided-needle-sampling-in-breast-cancer-comparing-the-sensitivity-of-fine-needle-aspiration-cytology-and-core-needle-biopsy
#6
Ashley R Topps, Simon P Barr, Panagiotis Pikoulas, Susan A Pritchard, Anthony J Maxwell
BACKGROUND: Pre-operative ultrasound-guided needle sampling (UNS) of abnormal axillary lymph nodes in breast cancer can identify patients with axillary metastases and therefore rationalize patient care and inform decision-making. To obtain tissue diagnosis, UNS can be performed by either fine needle aspiration (FNA) or core needle biopsy (CNB). However, few studies have compared the sensitivity of these techniques and the majority show no difference. METHODS: All node-positive patients (those with micro- and macrometastases but not isolated tumor cells) treated at a tertiary referral center between January 2012 and December 2015 were retrospectively identified from pathology records...
October 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29058788/significant-skin-tightening-by-closure-of-fractional-ablative-laser-holes
#7
Elisabeth Russe, Martin Purschke, Wikunda Limpiangkanan, William A Farinelli, Ying Wang, Apostolos G Doukas, Fernanda H Sakamoto, Gottfried Wechselberger, Richard Rox Anderson
BACKGROUND AND OBJECTIVE: Ablative fractional laser treatment uses thousands of very small laser beam wounds to damage a fraction of the skin, which stimulates tissue remodeling. Each open micro-wound heals without scarring, but the amount of skin tightening achieved is limited. This animal study was performed to test the hypothesis that immediate temporary closure of fractional laser wounds could increase skin tightening after fractional ablative laser treatment. MATERIALS AND METHODS: Four adult swine were used for the study; 98 square test sites (3 × 3 cm) were tattooed on the abdomen and flanks of each pig...
October 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29056444/long-lived-tissue-resident-hiv-1-specific-memory-cd8-t-cells-are-generated-by-skin-immunization-with-live-virus-vectored-microneedle-arrays
#8
Marija Zaric, Pablo Daniel Becker, Catherine Hervouet, Petya Kalcheva, Barbara Ibarzo Yus, Clement Cocita, Lauren Alexandra O'Neill, Sung-Yun Kwon, Linda Sylvia Klavinskis
The generation of tissue resident memory (TRM) cells at the body surfaces to provide a front line defence against invading pathogens represents an important goal in vaccine development for a wide variety of pathogens. It has been widely assumed that local vaccine delivery to the mucosae is necessary to achieve that aim. Here we characterise a novel micro-needle array (MA) delivery system fabricated to deliver a live recombinant human adenovirus type 5 vaccine vector (AdHu5) encoding HIV-1 gag. We demonstrate rapid dissolution kinetics of the microneedles in skin...
October 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29052557/determination-of-volatile-organic-compounds-in-exhaled-breath-of-heart-failure-patients-by-needle-trap-micro-extraction-coupled-with-gas-chromatography-tandem-mass-spectrometry
#9
Denise Biagini, Tommaso Lomonaco, Silvia Ghimenti, Francesca Giuseppa Bellagambi, Massimo Onor, Maria Chiara Scali, Valentina Barletta, Mario Marzilli, Pietro Salvo, Maria Giovanna Trivella, Roger Fuoco, Fabio Di Francesco
The analytical performances of needle trap micro-extraction (NTME) coupled with gas chromatography tandem mass spectrometry were evaluated by analyzing a mixture of twenty-two representative breath VOCs belonging to different chemical classes (i.e. hydrocarbons, ketones, aldehydes, aromatics and sulfurs). NTME is an emerging technique that guarantees detection limits in pptv range by pre-concentrating low volumes of sample, and it is particularly suitable for breath analysis. For most VOCs, detection limits between 20 and 500 pptv were obtained by pre-concentrating 25 mL of a humidified standard gas mixture at a flow rate of 15 mL/min...
October 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29037893/gelatin-promotes-rapid-restoration-of-the-blood-brain-barrier-after-acute-brain-injury
#10
Lucas S Kumosa, Valdemar Zetterberg, Jens Schouenborg
Gelatin coating of brain implants is known to provide considerable benefits in terms of reduced inflammatory sequalae and long-term neuroprotective effects. However, the mechanisms for gelatin's protective role in brain injury are still unknown. To address this question, cellular and molecular markers were studied with quantitative immunohistochemical microscopy at acute (<2 hours, 1, 3 days), intermediate (1-2 weeks) and long-term time points (6 weeks) after transient insertion of stainless steel needles into female rat cortex cerebri with or without gelatin coating...
October 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29030959/ipsc-derived-vascular-cell-spheroids-as-building-blocks-for-scaffold-free-biofabrication
#11
Leni Moldovan, April Barnard, Chang-Hyun Gil, Yang Lin, Maria B Grant, Mervin C Yoder, Nutan Prasain, Nicanor I Moldovan
Recently a protocol is established to obtain large quantities of human induced pluripotent stem cells (iPSC)-derived endothelial progenitors, called endothelial colony forming cells (ECFC), and of candidate smooth-muscle forming cells (SMFC). Here, the suitability for assembling in spheroids, and in larger 3D cell constructs is tested. iPSC-derived ECFC and SMFC are labeled with tdTomato and eGFP, respectively. Spheroids are formed in ultra-low adhesive wells, and their dynamic proprieties are studied by time-lapse microscopy, or by confocal microscopy...
October 14, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29027978/feedback-system-control-optimized-electrospinning-for-fabrication-of-an-excellent-superhydrophobic-surface
#12
Jian Yang, Chuangui Liu, Boqian Wang, Xianting Ding
Superhydrophobic surface, as a promising micro/nano material, has tremendous applications in biological and artificial investigations. The electrohydrodynamics (EHD) technique is a versatile and effective method for fabricating micro- to nanoscale fibers and particles from a variety of materials. A combination of critical parameters, such as mass fraction, ratio of N, N-Dimethylformamide (DMF) to Tetrahydrofuran (THF), inner diameter of needle, feed rate, receiving distance, applied voltage as well as temperature, during electrospinning process, to determine the morphology of the electrospun membranes, which in turn determines the superhydrophobic property of the membrane...
October 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28960481/comparison-of-the-effects-of-once-weekly-and-once-daily-rhpth-1-34-injections-on-promoting-fracture-healing-in-rodents
#13
Wen Zhang, Junxiong Zhu, Teng Ma, Can Liu, Bao Hai, Guohong Du, Hong Wang, Nan Li, Huijie Leng, Yingsheng Xu, Chunli Song
To compare the efficacy of once-weekly and once-daily subcutaneous injections of teriparatide (recombinant human parathyroid hormone 1-34) on fracture healing, 50 adult male Sprague-Dawley rats were subjected to a unilateral tibia fracture and received internal fixation with a Kirschner needle. Based on the injection dose and frequency, the rats were randomly divided into five groups (n = 10 each): subcutaneous injections of saline or 10 µg/kg/w, 20 µg/kg/w, 10 µg/kg/d and 20 µg/kg/d teriparatide...
September 28, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28946634/towards-robot-assisted-retinal-vein-cannulation-a-motorized-force-sensing-microneedle-integrated-with-a-handheld-micromanipulator-%C3%A2
#14
Berk Gonenc, Jeremy Chae, Peter Gehlbach, Russell H Taylor, Iulian Iordachita
Retinal vein cannulation is a technically demanding surgical procedure where therapeutic agents are injected into the retinal veins to treat occlusions. The clinical feasibility of this approach has been largely limited by the technical challenges associated with performing the procedure. Among the challenges to successful vein cannulation are identifying the moment of venous puncture, achieving cannulation of the micro-vessel, and maintaining cannulation throughout drug delivery. Recent advances in medical robotics and sensing of tool-tissue interaction forces have the potential to address each of these challenges as well as to prevent tissue trauma, minimize complications, diminish surgeon effort, and ultimately promote successful retinal vein cannulation...
September 23, 2017: Sensors
https://www.readbyqxmd.com/read/28946604/impulse-powered-needle-free-syringe-for-vaccine-drug-injection
#15
N Battula, V Menezes, S Bhalekar, S H Bhalekar, S M Nejad, H Hosseini
A needle-free vaccine/drug injector that works by virtue of the impulse of a moving shock wave is presented in this communication. The device can deliver controlled micro-volumes of liquid vaccines into skin and soft tissue targets in human with minimal invasion. The operation of the injector was investigated by delivering a dyed liquid into human skin samples and soft tissue models. The depth of penetration of the liquid was examined by histology of the targeted human skin samples. The delivery mechanics and the depth of penetration were analyzed theoretically with an elastic model for the skin and a viscoelastic model for the soft tissue targets, and a good agreement with experiments was observed...
September 15, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28917867/nanocrystalline-cellulose-isolated-from-discarded-cigarette-filters
#16
Segun A Ogundare, Vashen Moodley, Werner E van Zyl
We report the isolation of nanocrystalline cellulose (NCC) produced from discarded cigarette filters (DCF). The DCF were processed into cellulose via ethanolic extraction, hypochlorite bleaching, alkaline deacetylation, and then converted into NCC by sulfuric acid hydrolysis. The morphological structures of the isolated NCC established with TEM showed that the nanocrystals were needle-like with a mean length of 143nm. FEGSEM showed the morphological transition of the micro-sized DCF to self-assembled NCC while EDX revealed the presence of Ti (as TiO2) in DCF, which was retained in the NCC...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917706/the-effects-of-needle-damage-on-annulus-fibrosus-micromechanics
#17
Claudio Vergari, Jessica C Mansfield, Daniel Chan, Andrew Clarke, Judith R Meakin, Peter C Winlove
Needle puncture of the intervertebral disc can initiate a mechanical and biochemical cascade leading to disc degeneration. Puncture's mechanical effects have been shown near the puncture site, mechanical effects should be observed far, relative to needle size, from the puncture site, given the disc-wide damage induced by the stab. The aim of this work was to quantify these far-field effects, and to observe the local structural damage provoked by the needle. Strips of cow tail annulus fibrosus underwent two consecutive mechanical loadings to 5% tensile strain; fifteen samples were punctured in a radial direction with a randomly assigned needle between the two loadings (needle gauges between 19 and 23)...
November 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28910711/a-novel-micro-to-macro-structural-approach-for-mechanical-characterization-of-adipose-tissue-extracellular-matrix
#18
Behzad Seyfi, Nasser Fatouraee, Abbas Samani
Mechanical characterization of adipose tissue micro-components is important for various biomedical applications such as tissue engineering and predicting adipose tissue response to forces involved in relevant medical intervention procedures (e.g. breast needle biopsy). For this characterization, we introduce a novel structural method for micromechanical modeling of the adipose tissue. The micromechanical model was developed using fluid-structure interaction (FSI) formulation. We utilized this model within an inverse problem framework to estimate the hyperelastic parameters of adipose tissue extracellular matrix (ECM)...
September 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28904650/dermatologic-microsutures-using-human-hair-a-useful-technique-in-cutaneous-stitching
#19
Mohammed Al Azrak, Rei Ogawa
Background: Facial wounds are challenging for dermatologic surgeons, particularly traumatic facial wounds, because they can yield disfiguring scars. To obtain good results, narrow needles and sutures are needed. Hair filaments have a very small diameter (0.06-0.1 mm) and could serve as suture threads for facial wounds. Objective: To determine the aesthetic outcomes by using autologous hair to suture facial wounds. Patients and Methods: This case series study examined the aesthetic outcomes of all consecutive female patients with traumatic facial wounds who underwent autologous hair-based stitching in 2009-2016...
2017: Eplasty
https://www.readbyqxmd.com/read/28900134/minimally-invasive-micro-indentation-mapping-tissue-mechanics-at-the-tip-of-an-18g-needle
#20
Steven V Beekmans, Kaj S Emanuel, Theodoor H Smit, Davide Iannuzzi
Experiments regarding the mechanical properties of soft tissues mostly rely on data collected on specimens that are extracted from their native environment. During the extraction and in the time period between the extraction and the completion of the measurements, however, the specimen may undergo structural changes which could generate unwanted artifacts. To further investigate the role of mechanics in physiology and possibly use it in clinical practices, it is thus of paramount importance to develop instruments that could measure the viscoelastic response of a tissue without necessarily excising it...
September 12, 2017: Scientific Reports
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