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https://www.readbyqxmd.com/read/27917703/principles-of-the-kenzan-method-for-robotic-cell-spheroid-based-3d-bioprinting
#1
Nicanor I Moldovan, Narutoshi Hibino, Koichi Nakayama
Bioprinting is a technology with the prospect to change the way many diseases are treated, by replacing the damaged tissues with live, de novo created bio-similar constructs. However, after more than a decade of incubation and many proofs-of-concept, the field is still in its infancy. The current stagnation is the consequence of its early success: the first bioprinters, and most of those which followed, were modified versions of the 3D printers used in additive manufacturing, redesigned for layer-by-layer dispersion of biomaterials...
December 4, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27897312/the-feasibility-of-micro-ultrasound-as-a-tool-to-image-peripheral-nerves
#2
A Chandra, R Eisma, P Felts, S Munirama, G A Corner, C E M Demore, G McLeod
Despite widespread use of ultrasound imaging to guide needle placement, the incidence of transient and permanent nerve damage as a complication of regional anaesthesia has not changed over the last decade. In view of the controversy surrounding intraneural injection there is a need to understand the structural changes caused by subepineural and subperineural needle penetration. Clinical ultrasound machines do not provide adequate anatomical resolution, and anaesthetists have difficulty judging the precise location of the needle tip relative to the epineurium...
November 29, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27884664/bacterial-contamination-of-saline-used-for-epidural-procedures-in-an-obstetric-setting-a-randomised-comparison-of-two-drawing-up-techniques
#3
M Onofrei, M Y Wee, B Parker, N Wee, S Hill
BACKGROUND: There is little evidence to inform practice regarding the optimum aseptic technique of drawing up saline for epidural insertion. Our regional practice is to draw up saline from a non-sterile packaged plastic ampoule, therefore introducing the risk of bacterial contamination. Usually, the anaesthetist draws up saline directly from the vial held by an assistant using a needle (needle technique). Alternatively, the saline vial is emptied onto a sterile tray by an assistant and then drawn up by the anaesthetist (tray technique)...
October 8, 2016: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/27845552/breast-angiosarcoma-with-exophytic-growth
#4
Donya Farrokh, Elaheh Modoodi, Yalda Fallah Rastegar
Primary angiosarcoma of the breast is a rare malignant tumor. Diagnostic breast imaging includes mammography and ultrasound, which are usually nonspecific. A 42-year-old woman with angiosarcoma of the breast is presented. Physical findings showed a hard exophytic mass in the upper part of the left breast, with skin discoloration overlaying the mass. Mammography revealed a high density well defined mass in the left breast, without any micro-calcification and speculation. On ultrasound examination, a hypoechoic mass with a well-defined margin and heterogenous echogenicity was detected...
November 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27802934/commentary-on-micro-needling-depth-penetration-presence-of-pigment-particles-and-fluorescein-stained-platelets-clinical-usage-for-aesthetic-concerns
#5
Des Fernandes
No abstract text is available yet for this article.
November 1, 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27782598/design-and-construction-of-keda-space-plasma-experiment-kspex-for-the-investigation-of-the-boundary-layer-processes-of-ionospheric-depletions
#6
Yu Liu, Zhongkai Zhang, Jiuhou Lei, Jinxiang Cao, Pengcheng Yu, Xiao Zhang, Liang Xu, Yaodong Zhao
In this work, the design and construction of the Keda Space Plasma EXperiment (KSPEX), which aims to study the boundary layer processes of ionospheric depletions, are described in detail. The device is composed of three stainless-steel sections: two source chambers at both ends and an experimental chamber in the center. KSPEX is a steady state experimental device, in which hot filament arrays are used to produce plasmas in the two sources. A Macor-mesh design is adopted to adjust the plasma density and potential difference between the two plasmas, which creates a boundary layer with a controllable electron density gradient and inhomogeneous radial electric field...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27770923/in-situ-synthesis-of-magnetic-iron-oxide-nanoparticle-nanofibre-composites-using-electrospinning
#7
Luke Burke, Chris J Mortimer, Daniel J Curtis, Aled R Lewis, Rhodri Williams, Karl Hawkins, Thierry G G Maffeis, Chris J Wright
We demonstrate a facile, one-step process to form polymer scaffolds composed of magnetic iron oxide nanoparticles (MNPs) contained within electrospun nano- and micro-fibres of two biocompatible polymers, Poly(ethylene oxide) (PEO) and Poly(vinyl pyrrolidone) (PVP). This was achieved with both needle and free-surface electrospinning systems demonstrating the scalability of the composite fibre manufacture; a 228 fold increase in fibre fabrication was observed for the free-surface system. In all cases the nanoparticle-nanofibre composite scaffolds displayed morphological properties as good as or better than those previously described and fabricated using complex multi-stage techniques...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27752098/uniting-superhydrophobic-superoleophobic-and-lubricant-infused-slippery-behavior-on-copper-oxide-nano-structured-substrates
#8
Sanjeev Kumar Ujjain, Pritam Kumar Roy, Sumana Kumar, Subhash Singha, Krishnacharya Khare
Alloys, specifically steel, are considered as the workhorse of our society and are inimitable engineering materials in the field of infrastructure, industry and possesses significant applications in our daily life. However, creating a robust synthetic metallic surface that repels various liquids has remained extremely challenging. The wettability of a solid surface is known to be governed by its geometric nano-/micro structure and the chemical composition. Here, we are demonstrating a facile and economical way to generate copper oxide micro-nano structures with spherical (0D), needle (1D) and hierarchical cauliflower (3D) morphologies on galvanized steel substrates using a simple chemical bath deposition method...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27713547/hierarchical-micro-nano-porous-acupuncture-needles-offering-enhanced-therapeutic-properties
#9
Su-Ll In, Young S Gwak, Hye Rim Kim, Abdul Razzaq, Kyeong-Seok Lee, Hee Young Kim, SuChan Chang, Bong Hyo Lee, Craig A Grimes, Chae Ha Yang
Acupuncture as a therapeutic intervention has been widely used for treatment of many pathophysiological disorders. For achieving improved therapeutic effects, relatively thick acupuncture needles have been frequently used in clinical practice with, in turn, enhanced stimulation intensity. However due to the discomforting nature of the larger-diameter acupuncture needles there is considerable interest in developing advanced acupuncture therapeutical techniques that provide more comfort with improved efficacy...
October 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27701917/sensitivity-improvements-of-a-resonance-based-tactile-sensor
#10
Yoshinobu Murayama, Olof A Lindahl
Resonance-based contact-impedance measurement refers to the application of resonance sensors based on the measurement of the changes in the resonance curve of an ultrasonic resonator in contact with a surface. The advantage of the resonance sensor is that it is very sensitive to small changes in the contact impedance. A sensitive micro tactile sensor (MTS) was developed, which measured the elasticity of soft living tissues at the single-cell level. In the present paper, we studied the method of improving the touch and stiffness sensitivity of the MTS...
February 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/27693432/pharmaceutical-and-biomaterial-engineering-via-electrohydrodynamic-atomization-technologies
#11
Prina Mehta, Rita Haj-Ahmad, Manoochehr Rasekh, Muhammad S Arshad, Ashleigh Smith, Susanna M van der Merwe, Xiang Li, Ming-Wei Chang, Zeeshan Ahmad
Complex micro- and nano-structures enable crucial developments in the healthcare remit (e.g., pharmaceutical and biomaterial sciences). In recent times, several technologies have been developed and explored to address key healthcare challenges (e.g., advanced chemotherapy, biomedical diagnostics and tissue regeneration). Electrohydrodynamic atomization (EHDA) technologies are rapidly emerging as promising candidates to address these issues. The fundamental principle driving EHDA engineering relates to the action of an electric force (field) on flowing conducting medium (formulation) giving rise to a stable Taylor cone...
September 28, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27681360/targeting-of-sebaceous-glands-to-treat-acne-by-micro-insulated-needles-with-radio-frequency-in-a-rabbit-ear-model
#12
Tae-Rin Kwon, Eun Ja Choi, Chang Taek Oh, Dong-Ho Bak, Song-I Im, Eun Jung Ko, Hyuck Ki Hong, Yeon Shik Choi, Joon Seok, Sun Young Choi, Gun Young Ahn, Beom Joon Kim
BACKGROUND AND OBJECTIVES: Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro-insulated needle RF applicator has not yet been studied in an animal model. The purpose of this study was to evaluate the effectiveness of a micro-insulated needle RF applicator in a rabbit ear acne (REA) model. STUDY DESIGN/MATERIALS AND METHODS: In this study, we investigated the effect of selectively destroying the sebaceous glands using a micro-insulated needle RF applicator on the formation of comedones induced by application of 50% oleic acid and intradermal injection of P...
September 29, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27667019/in-situ-mechanical-and-molecular-investigations-of-collagen-apatite-biomimetic-composites-combining-raman-spectroscopy-and-stress-strain-analysis
#13
Konstantinos Chatzipanagis, Christoph G Baumann, Monica Sandri, Simone Sprio, Anna Tampieri, Roland Kröger
: We report the design, fabrication and application of a novel micro-electromechanical device coupled to a confocal Raman microscope that enables in situ molecular investigations of micro-fibers under uniaxial tensile load. This device allows for the mechanical study of micro-fibers with diameters in the range between 10 and 100μm and lengths of several hundred micrometers. By exerting forces in the mN range, the device enables an important force range to be accessed between that of atomic force microscopy and macroscopic stress-strain measurement devices...
September 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27602348/subchondral-bone-remodeling-comparing-nanofracture-with-microfracture-an-ovine-in-vivo-study
#14
Pietro Zedde, Sebastiano Cudoni, Giacomo Giachetti, Maria Lucia Manunta, Gerolamo Masala, Antonio Brunetti, Andrea Fabio Manunta
PURPOSE: microfracture, providing direct stimulation of chondrogenic mesenchymal stem cells (MSCs) in the subchondral bone, remains the most frequently used primary cartilage repair technique. However, the newly formed type I collagen-rich fibrocartilaginous tissue has poor biomechanical properties and a tendency to degenerate. To overcome these limitations the nanofracture technique was introduced. Our purpose was to compare subchondral bone remodeling 6 months after microfracture versus nanofracture (subchondral needling) treatment in an ovine model...
April 2016: Joints
https://www.readbyqxmd.com/read/27593268/synthesis-of-tio2-visible-light-catalysts-with-controllable-crystalline-phase-and-morphology-from-ti-bearing-electric-arc-furnace-molten-slag
#15
Yang Li, Lulu Liu, Min Guo, Mei Zhang
TiO2 visible light catalysts with different crystalline phases and morphologies were synthesized from titanium-bearing electric arc furnace molten slag (Ti-bearing EAF slag) by using a simple acidolysis process. The effects of the pH of the HCl solution, liquid to solid ratio (RL/S, HCl solution to the residue ratio, mL/g) and acidolysis time on the micro-morphology and crystalline phase of as-prepared TiO2 photocatalysts were systematically investigated. The results indicated that with decreasing pH in the HCl solution and increasing RL/S, the crystalline phase and micro-morphology of the obtained TiO2 nanostructures tended to transform from anatase type TiO2 with spherical nanoparticle structures to rutile type TiO2 with needle-like nanorod structures...
September 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/27589679/micro-carcinoma-only-a-diagnostic-epidemic
#16
Paolo Del Rio, Chiara Montana Montana, Giulia Mingardi, Giovanna Piva, Mario Sianesi, Luigi Corcione
BACKGROUND: The incidence of thyroid carcinoma goes from 0.5 to 10 cases on 100.000, depending on the country, the context and purpose of the study. The high incidence of differentiated thyroid tumor is continuously growing. While most malignant pathologies affect the adults, a proportion of 1-2 % of paediatric population is affected by solitary nodule, of which some are malignant cancers. Studying thyroid malignant cancer, the most sensitive and accurate imaging technique is the colorDoppler ultrasounds...
September 2, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27583578/spatial-measurements-of-perfusion-interstitial-fluid-pressure-and-liposomes-accumulation-in-solid-tumors
#17
Shawn Stapleton, Daniel Mirmilshteyn, Jinzi Zheng, Christine Allen, David A Jaffray
The heterogeneous intra-tumoral accumulation of liposomes is a critical determinant of their efficacy. Both the chaotic tumor microcirculation and elevated IFP are linked to the heterogeneous intra-tumoral distribution of nanotechnology-based drug delivery systems such as liposomes. In the present study, the relationship between tumor microcirculation, elevated IFP, and accumulation of nanoparticles was investigated through in vivo experimentation. This was accomplished by evaluation of the tumor microcirculation using dynamic contrast enhanced computed tomography (DCE-CT) and measurement of tumor IFP using a novel image-guided robotic needle placement system connected to the micro-CT scanner...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27574909/a-review-of-genetic-engineering-biotechnologies-for-enhanced-chronic-wound-healing
#18
John W Sessions, David G Armstrong, Sandra Hope, Brian D Jensen
Traditional methods for addressing chronic wounds focus on correcting dysfunction by controlling extracellular elements. This review highlights technologies that take a different approach - enhancing chronic wound healing by genetic modification to wound beds. Featured cutaneous transduction/transfection methods include viral modalities (i.e. adenoviruses, adeno-associated viruses, retroviruses, and lentiviruses) and conventional non-viral modalities (i.e. naked DNA injections, micro-seeding, liposomal reagents, particle bombardment, and electroporation)...
August 30, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27569041/the-challenge-of-rapid-diagnosis-in-oncology-diagnostic-accuracy-and-cost-analysis-of-a-large-scale-one-stop-breast-clinic
#19
Suzette Delaloge, Julia Bonastre, Isabelle Borget, Jean-Rémi Garbay, Rachel Fontenay, Diane Boinon, Mahasti Saghatchian, Marie-Christine Mathieu, Chafika Mazouni, Sofia Rivera, Catherine Uzan, Fabrice André, Clarisse Dromain, Bruno Boyer, Barbara Pistilli, Sandy Azoulay, Françoise Rimareix, El-Hadi Bayou, Benjamin Sarfati, Hélène Caron, Amal Ghouadni, Nicolas Leymarie, Sandra Canale, Muriel Mons, Julia Arfi-Rouche, Monica Arnedos, Voichita Suciu, Philippe Vielh, Corinne Balleyguier
PURPOSE: Rapid diagnosis is a key issue in modern oncology, for which one-stop breast clinics are a model. We aimed to assess the diagnosis accuracy and procedure costs of a large-scale one-stop breast clinic. PATIENTS AND METHODS: A total of 10,602 individuals with suspect breast lesions attended the Gustave Roussy's regional one-stop breast clinic between 2004 and 2012. The multidisciplinary clinic uses multimodal imaging together with ultrasonography-guided fine needle aspiration for masses and ultrasonography-guided and stereotactic biopsies as needed...
October 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27565822/rapid-fabrication-method-of-a-microneedle-mold-with-controllable-needle-height-and-width
#20
Yen-Heng Lin, I-Chi Lee, Wei-Chieh Hsu, Ching-Hong Hsu, Kai-Ping Chang, Shao-Syuan Gao
The main issue of transdermal drug delivery is that macromolecular drugs cannot diffuse through the stratum corneum of skin. Many studies have pursued micro-sized needles encapsulated with drugs to overcome this problem, as these needles can pierce the stratum corneum and allow drugs to enter the circulatory system of the human body. However, most microneedle fabrication processes are time-consuming and require expensive equipment. In this study, we demonstrate a rapid method for fabricating a microneedle mold using drawing lithography and a UV-cured resin...
October 2016: Biomedical Microdevices
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