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https://www.readbyqxmd.com/read/28296143/targeting-the-safe-zone
#1
Andrea Mignatti, Patricia Friedmann, David Paul Slovut
OBJECTIVE: The aim of this study was to assess the effectiveness of a quality improvement (QI) program in reducing vascular complications during cardiac catheterization. BACKGROUND: Vascular access complications during cardiac catheterization are associated with higher morbidity and mortality. We implemented a QI program focused on using micropuncture techniques and targeting the "safe zone," an area below the inferior border of the inferior epigastric artery and above the inferior border of the femoral head, for femoral artery puncture...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28285075/thermally-triggered-hydrogel-injection-into-bovine-intervertebral-disc-tissue-explants-induces-differentiation-of-mesenchymal-stem-cells-and-restores-mechanical-function
#2
A A Thorpe, G Dougill, L Vickers, N D Reeves, C Sammon, G Cooper, C L Le Maitre
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6 weeks...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28275513/extending-indications-of-micropercutaneous-nephrolithotomy-it-is-not-just-about-cracking-stones
#3
Arvind P Ganpule, Jaspreet Singh Chhabra, S B Sudharsan, Ankush Jairath, Mohankumar Vijaykumar, Ravindra Sabnis, Mahesh R Desai
OBJECTIVE: To describe our experience and results of using the MicroPerc™ micropercutaneous nephrolithotomy armamentarium (PolyDiagnost, Germany) for unusual indications unexplored using this modality. PATIENTS AND METHODS: We used the MicroPerc™ system for stone clearance in three ureteric calculi, two bladder calculi, one case of urethral calculus, for antegrade biopsy in a case of upper tract urothelial carcinoma, for Deflux® (dextranomer/hyaluronic copolymer, Salix Pharmaceuticals, Uppsala, Sweden) injection in three cases of vesico-ureteric reflux (VUR), and three cases of posterior urethral valve (PUV) fulgurations...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28236012/application-of-a-computer-assisted-flexible-endoscope-system-for-transoral-surgery-of-the-hypopharynx-and-upper-esophagus
#4
Daniel T Friedrich, M O Scheithauer, J Greve, N Rotter, J Doescher, T K Hoffmann, P J Schuler
Zenker's diverticulum is a common pathology in the transition zone of the posterior hypopharynx and esophagus. Surgical treatment is routinely performed by ENT and general surgeons. Besides the traditional open transcervical diverticulectomy, the introduction of transoral rigid treatment led to a paradigm change and is now the preferred treatment option for patients who are fit for general anesthesia. The implementation of interventional flexible endoscopy has opened another new micro-invasive approach for patients with high morbidity...
February 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28215667/microneedle-bio-microneedle-and-bio-inspired-microneedle-a-review
#5
REVIEW
Guojun Ma, Chengwei Wu
Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows them with many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs. The objective of this review is mainly to introduce studies on the mechanics problems with respect to MNs. Firstly, the basic knowledge of MNs is introduced in brief, so that readers can understand the basic characteristics of MNs...
February 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28212074/a-review-of-in-body-biotelemetry-devices-implantables-ingestibles-and-injectables
#6
Asimina Kiourti, Konstantina S Nikita
We present a review of wireless medical devices that are placed inside the human body to realize many and different sensing and/or stimulating functionalities. METHODS: A critical literature review analysis is conducted focusing on three types of in-body medical devices, i.e., a) devices that are implanted inside the human body (implantables), b) devices that are ingested like regular pills (ingestibles), and c) devices that are injected into the human body via needles (injectables). Design considerations, current status and future directions related to the aforementioned in-body devices are discussed...
February 14, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28194985/nano-endoscopy-with-plasmon-enhanced-fluorescence-for-sensitive-sensing-inside-ultrasmall-volume-samples
#7
Hang Yuan, Jie Liu, Yuexiang Lu, Zhe Wang, Guoyu Wei, Tianhao Wu, Gang Ye, Jing Chen, Sichun Zhang, Xinrong Zhang
Plasmon-enhanced fluorescence (PEF) generally requires the samples settled on a metal substrate and the effective enhancement distance is less than 100 nm, which limit its application in intracellular sensing. Herein, we report a nano endoscopy with PEF effect for sensing analytes inside the extremely small volume samples. The nano endoscopy was fabricated by assembling single nanoporous gold nanowire (PGNW) on the tip of a tungsten needle. It was accurately manipulated to insert into a micro droplet, and an effective sensing was realized at micrometre scale with submicrometer resolution...
January 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28181673/laser-induced-thermal-coagulation-enhances-skin-uptake-of-topically-applied-compounds
#8
C S Haak, J Hannibal, U Paasch, R R Anderson, M Haedersdal
BACKGROUND: Ablative fractional laser (AFL) generates microchannels in skin surrounded by a zone of thermally altered tissue, termed the coagulation zone (CZ). The thickness of CZ varies according to applied wavelength and laser settings. It is well-known that AFL channels facilitate uptake of topically applied compounds, but the importance of CZ is unknown. METHODS: Franz Cells were used to investigate skin uptake and permeation of fluorescent labeled polyethylene glycols (PEGs) with mean molecular weights (MW) of 350, 1,000, and 5,000 Da...
February 9, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28171813/effect-of-honeybee-stinger-and-its-microstructured-barbs-on-insertion-and-pull-force
#9
Jintian Ling, Zhenhua Song, Jiarui Wang, Keyun Chen, Jiyu Li, Shujia Xu, Lei Ren, Zhipeng Chen, Dianwen Jin, Lelun Jiang
Worker honeybee is well-known for its stinger with microscopic backward-facing barbs for self-defense. The natural geometry of the stinger enables painless penetration and adhesion in the human skin to deliver poison. In this study, Apis cerana worker honeybee stinger and acupuncture microneedle (as a barbless stinger) were characterized by Scanning Electron Microscope (SEM). The insertion and pull process of honeybee stinger into rabbit skin was performed by a self-developed mechanical loading equipment in comparison with acupuncture needle...
January 25, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28160573/shear-wave-elastography-combined-with-the-thyroid-imaging-reporting-and-data-system-for-malignancy-risk-stratification-in-thyroid-nodules
#10
Zhao Liu, Hui Jing, Xue Han, Hua Shao, Yi-Xin Sun, Qiu-Cheng Wang, Wen Cheng
To retrospectively evaluate the diagnostic performance of shear wave elastography (SWE) and thyroid imaging reporting and data system (TI-RADS) in differentiating malignant and benign thyroid nodules. A total of 313 thyroid nodules in 227 patients were included. All thyroid nodules were underwent SWE and TI-RADS before fine needle aspiration biopsy and/or surgery. SWE elasticity indices of the maximum (Emax), mean (Emean), minimum (Emin) and elastic ratio (ER) in thyroid nodules were measured. Nodules with solid component, marked hypoechogenicity, poorly defined margins, micro-calcifications, and a taller-than-wide shape were classified as suspicious at gray-scale ultrasonography...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28153482/climbing-upstream-multi-scale-structural-characterization-and-underwater-adhesion-of-the-pulin-river-loach-sinogastromyzon-puliensis
#11
Yung-Chieh Chuang, Haw-Kai Chang, Guan-Lin Liu, Po-Yu Chen
Hillstream fishes live in the current with high flow velocity and strong water impact. To survive in such environments, they evolved various adhesive apparatus and attachment mechanisms. In this study, we investigated the Pulin river loach (Sinogatromyzon puliensis) known for its ability to climb vertically against rapid torrent. The whole body forms a suction system, consisting of lips, overlapped pectoral and fused pelvic fins. The hierarchical structure of lips and fins was characterized by Scanning Electron Microscopy...
January 23, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28133206/-difficult-decision-about-a-surgical-margin-for-a-non-invasive-apocrine-carcinoma-in-the-breast-report-of-a-case
#12
Tomohiro Hirano, Kenichi Sakurai, Shigeru Fujisaki, Keita Adachi, Shuhei Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Katsuhisa Enomoto, Ryouichi Tomita, Kenji Gonda
We report a case of non-invasive apocrine carcinoma. In this case, we could not identifythe surgical margin. The patient was 39-year-old woman. Micro calcifications were discovered on her right breast during breast cancer screening. Stereotactic vacuum assisted core needle biopsywas performed and the pathological diagnosis was sclerosing adenosis. A low echoic lesion, 26mm in diameter, was discovered in the CDE area of her left breast byultrasonography . A contrast enhanced MRI showed a high intensityarea, 26mm in diameter, on her left breast...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28118551/the-utility-of-in-office-ultrasound-in-the-diagnosis-of-parotid-lesions
#13
Yarah M Haidar, Omid Moshtaghi, Amin Mahmoodi, Mohammad Helmy, Julie A Goddard, William B Armstrong
Objective To determine whether the use of in-office ultrasound (US) by a head and neck surgeon is a useful adjunct to clinical assessment of parotid lesions and decrease the need of additional imaging, such as magnetic resonance imaging (MRI) or computed tomography (CT). Study Design Case series with chart review. Setting Tertiary care academic center. Subjects Seventy patients presenting with a parotid lesion who obtained an in-office US and ultrasound-guided fine-needle aspiration (USGFNA) from a head and neck surgeon from 2006 to 2015...
March 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28077785/the-diagnostic-performance-of-shear-wave-speed-sws-imaging-for-thyroid-nodules-with-elasticity-modulus-and-sws-measurement
#14
Dan Wang, Ya-Ping He, Yi-Feng Zhang, Bo-Ji Liu, Chong-Ke Zhao, Hui-Jun Fu, Qing Wei, Hui-Xiong Xu
To evaluate the diagnostic performance of a new technique of shear wave speed (SWS) imaging for the diagnosis of thyroid nodule with elasticity modulus and SWS measurement. 322 thyroid nodules in 322 patients (216 benign nodules, 106 malignant nodules) were included in this study. All the nodules received conventional ultrasound (US) and SWS imaging (Aplio500, Toshiba Medical Systems, Japan) before fine-needle aspiration (FNA) and/or surgery. The values of E-max and E-mean with elastic modulus (61.27 ± 36...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28070698/drug-coated-microneedles-for-rapid-and-painless-local-anesthesia
#15
Sung-Hyun Baek, Ju-Hyung Shin, Yeu-Chun Kim
This study showed that drug-coated PLLA (Poly (L-lactide)) microneedle arrays can induce rapid and painless local anesthesia. Microneedle arrays were fabricated using a micro-molding technique, and the needle tips were coated with 290.6 ± 45.9 μg of lidocaine, the most widely used local anesthetic worldwide. A dip-coating device was newly designed for the coating step using an optimized coating formulation. Lidocaine coated on the arrays was released rapidly into PBS within 2 min, and its stability in storage lasted 3 weeks at 4, 25, and 37°C...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28069164/ex-vivo-thickness-measurement-of-cartilage-covering-the-temporomandibular-joint
#16
Fereshteh Mirahmadi, Jan Harm Koolstra, Frank Lobbezoo, G Harry van Lenthe, Vincent Everts
Articular cartilage covers the temporomandibular joint (TMJ) and provides smooth and nearly frictionless articulation while distributing mechanical loads to the subchondral bone. The thickness of the cartilage is considered to be an indicator of the stage of development, maturation, aging, loading history, and disease. The aim of our study was to develop a method for ex vivo assessment of the thickness of the cartilage that covers the TMJ and to compare that with two other existing methods. Eight porcine TMJ condyles were used to measure cartilage thickness...
December 19, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28067416/a-novel-technique-of-delivering-viral-vectors-to-trigeminal-ganglia-in-rats
#17
Hu Long, Lina Liao, Yang Zhou, Di Shan, Meiya Gao, Renhuan Huang, Xin Yang, Wenli Lai
The objective of this study was to develop a viable and reliable technique of delivering viral vectors to rat trigeminal ganglia. Adult Sprague-Dawley rats (200-300 g) were used, and lentiviral vectors containing enhanced green fluorescence protein and calcitonin gene-related peptide short hairpin RNA (shRNA) were generated. Following general anesthesia, viral vectors were delivered to rat trigeminal ganglia using the technique described in this study. Both X-ray and micro-computed tomography (micro-CT) were employed to verify the position of the needles when injecting the vectors...
January 9, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28057168/evaluation-and-optimization-of-blood-micro-sampling-methods-serial-sampling-in-a-cross-over-design-from-an-individual-mouse
#18
Nita J Patel, Enaksha Wickremsinhe, Yu-Hua Hui, Alexandar Barr, Nicholas Masterson, Kenneth Ruterbories, Jennifer Weller, Jennifer Hanes, Tom Kern, Everett Perkins
PURPOSE: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles.  The purpose of this work was to evaluate and optimize blood microsampling techniques coupled with dried blood spot (DBS) and LC-MS/MS analysis to generate reliable PK data in mice.  In addition, the feasibility of cross-over designs was assessed and recommendations are presented. METHODS: The work describes a comprehensive evaluation of five blood microsampling techniques (tail clip, tail vein with needle hub, submandibular, retro-orbital, and saphenous bleeding) in CD-1 mice...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28009845/improvement-of-depth-profiling-into-biotissues-using-micro-electrical-impedance-spectroscopy-on-a-needle-with-selective-passivation
#19
Joho Yun, Hyeon Woo Kim, Jong-Hyun Lee
A micro electrical impedance spectroscopy (EIS)-on-a-needle for depth profiling (μEoN-DP) with a selective passivation layer (SPL) on a hypodermic needle was recently fabricated to measure the electrical impedance of biotissues along with the penetration depths. The SPL of the μEoN-DP enabled the sensing interdigitated electrodes (IDEs) to contribute predominantly to the measurement by reducing the relative influence of the connection lines on the sensor output. The discrimination capability of the μEoN-DP was verified using phosphate-buffered saline (PBS) at various concentration levels...
December 21, 2016: Sensors
https://www.readbyqxmd.com/read/27939854/bayesian-analysis-of-high-resolution-ultrasonography-and-guided-fine-needle-aspiration-cytology-in-diagnosis-of-palpable-thyroid-nodules
#20
Niranjan Sahu, Rabindra Nath Padhy
INTRODUCTION: To evaluate diagnostic accuracy of high-resolution ultrasonography in differentiation of benign and malignant thyroid nodules in comparison to results of guided fine needle aspiration cytology based on the Bayes rule. OBJECTIVE: To assess the validity of ultrasonography results of thyroid nodules in comparison to guided fine needle aspiration cytology findings. METHODS: This study was done on randomly chosen 80 patients presented with palpable thyroid nodules, undergone real-time sonographic evaluation of thyroid nodules to characterize features, internal consistency, margins, echotexture, calcification, peripheral lucent halo and vascularity...
November 17, 2016: Brazilian Journal of Otorhinolaryngology
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