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https://www.readbyqxmd.com/read/29350125/current-management-migraine-headache
#1
Stephen D Silberstein
Migraine varies in its frequency, severity, and impact; treatment should consider these variations and the patient's needs and goals. Migraine pharmacologic treatment may be acute (abortive) or preventive (prophylactic), and patients often require both. New medication devices are available or in development, including an intracutaneous, microneedle system of zolmitriptan and sumatriptan, and breath-powered powder sumatriptan intranasal treatment. Lasmiditan, a 5-HT1F receptor agonist, is in development for acute treatment, as are small molecule calcitonin gene-related peptide (CGRP) receptor antagonists (Gepants) for acute and preventive treatment...
December 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29348670/intradermal-delivery-of-stat3-sirna-to-treat-melanoma-via-dissolving-microneedles
#2
Jingtong Pan, Wenyi Ruan, Mengyao Qin, Yueming Long, Tao Wan, Kaiyue Yu, Yuanhao Zhai, Chuanbin Wu, Yuehong Xu
Hyperactivity of signal transducer and activity of transcription 3 (STAT3) plays a crucial role in melanoma invasion and metastasis. Gene therapy applying siRNA targeting STAT3 is a potential therapeutic strategy for melanoma. In this article, we first fabricated safe and novel dissolving microneedles (MNs) for topical application of STAT3 siRNA to enhance the skin penetration of siRNA and used polyethylenimine (PEI, 25 kDa) as carrier to improve cellular uptake of siRNA. The results showed that MNs can effectively penetrate skin and rapidly dissolve in the skin...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348573/exendin-4-encapsulated-dissolving-microneedle-arrays-for-efficient-treatment-of-type-2-diabetes
#3
Shayan Fakhraei Lahiji, Yoojung Jang, Inyoung Huh, Huisuk Yang, Mingyu Jang, Hyungil Jung
Dissolving microneedles (DMNs) are microscopic needles capable of delivering encapsulated compounds and releasing them into the skin in a minimally invasive manner. Most studies indicate that encapsulating therapeutics in DMNs is an efficacious approach; however, the importance of evaluating the activity of encapsulated compounds, during the fabrication process, has not been examined in detail. Conducting an analysis of thermal, chemical, and physical stress factors, including temperature, pH, and the interaction of the polymer and therapeutics mixture during preparation, is essential for retaining the activity of encapsulated therapeutics during and after fabrication...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29346488/a-subretinal-cell-delivery-method-via-suprachoroidal-access-in-minipigs-safety-and-surgical-outcomes
#4
Marc D de Smet, Jessica L Lynch, Nadine S Dejneka, Michael Keane, I John Khan
Purpose: This study evaluated a new subretinal method for delivery of human or pig umbilical tissue-derived cells (hUTC or pUTC, respectively) using a novel subretinal injection cannula and suprachoroidal approach in Göttingen minipig eyes. hUTC (palucorcel) are currently under development for treating geographic atrophy in humans. Methods: Twenty-four Göttingen minipigs (divided into eight groups) were subretinally administered palucorcel, pUTC, or vehicle. In some cases, fluorescently labeled cells and vehicle were administered...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29345430/wearable-wireless-tyrosinase-bandage-and-microneedle-sensors-toward-melanoma-screening
#5
Bianca Ciui, Aida Martin, Rupesh K Mishra, Barbara Brunetti, Tatsuo Nakagawa, Thomas J Dawkins, Mengjia Lyu, Cecilia Cristea, Robert Sandulescu, Joseph Wang
Wearable bendable bandage-based sensor and a minimally invasive microneedle biosensor are described toward rapid screening of skin melanoma. These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level...
January 18, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29320590/treatment-of-d%C3%A3-colletage-photoaging-with-fractional-microneedling-radiofrequency
#6
Alexis Lyons, Jillian Roy, Jennifer Herrmann, Lisa Chipps
OBJECTIVES: The objective of this study was to examine the efficacy and safety of a novel fractional microneedling radiofrequency device to improve the appearance of rhytides and skin laxity of the décolletage. METHODS: Twelve subjects received a total of three fractional microneedling radiofrequency treatments with Endymed Intensif (EndyMed Ltd., Cesarea, Israel) at least three weeks apart. Primary outcome measure was clinical efficacy quantified by a patient survey to assess treatment satisfaction as well as a physician Global Aesthetic Improvement Scale (GAIS)...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29318969/confronting-penetration-threshold-via-fluidic-terpenoid-nanovesicles
#7
Kamla Pathak, Ankur Vaidya, Vijay Sharma
BACKGROUND: Improvisation of the nanosized vesicular systems has led to a series of useful developments including the deformable vesicles namely transfersomes, ethosomes and invasomes. While the former two have been explored extensively, literature on invasomes is relatively scanty. METHOD: Invasomal formulations researched for various applications have been reviewed using search engine "Scopus". The present review focuses on the update on the research activity on effectiveness and permeation enhancing effects of invasomes for dermal and topical delivery...
January 8, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29316083/near-infrared-fluorescent-molecular-probe-for-sensitive-imaging-of-keloid
#8
Qingqing Miao, David C Yeo, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu, Kanyi Pu
Early detection of skin diseases is imperative for their effective treatment. However, fluorescence molecular probes that allow this are rare. The first activatable near-infrared (NIR) fluorescent molecular probe is reported for sensitive imaging of keloid cells, skin cells from abnormal scar fibrous lesions. As keloid cells have high expression levels of fibroblast activation protein-alpha (FAPα), the probe (FNP1) is designed to have a caged NIR dye and a FAPα-cleavable peptide substrate linked by a self-immolative segment...
January 5, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29313035/peptide-delivery-with-poly-ethylene-glycol-diacrylate-microneedles-through-swelling-effect
#9
Shiying Liu, David C Yeo, Christian Wiraja, Hong Liang Tey, Milan Mrksich, Chenjie Xu
Transdermal delivery of therapeutic biomolecules (including peptides) can avoid enzymatic digestion that occurs in the oral route. (Polyethylene glycol) diacrylate (PEGDA)-based microneedles, with good biocompatibility, are easily fabricated through photo-polymerization with a precisely controlled structure. It has successfully been used for the transdermal delivery of small molecule drugs such as 5-fluorouracil. However, the delivery of peptide-based therapeutics using this platform is seldom reported. This is because of the potential damage to the peptide during the photo-polymerization process of PEGDA...
September 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29301433/in-vitro-and-in-vivo-assessment-of-polymer-microneedles-for-controlled-transdermal-drug-delivery
#10
Bo Zhi Chen, Mohammad Ashfaq, Xiao Peng Zhang, Jia Nan Zhang, Xin Dong Guo
Microneedles (MNs) system for transdermal drug delivery has the potential to improve therapeutic efficacy, proving an approach that is more convenient and acceptable than traditional medication systems. The present study systematically researched dissolving polymer MNs fabricated from various common FDA-approved biocompatible materials, including gelatin, chitosan, hyaluronic acid (HA) and polyvinyl alcohol (PVA). Upon application of MN patches to the porcine cadaver skin, the MNs effectively perforated the skin and delivered drugs to subcutaneous tissue on contact with the interstitial fluid...
January 5, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29301203/wireless-semg-system-with-a-microneedle-based-high-density-electrode-array-on-a-flexible-substrate
#11
Minjae Kim, Gangyong Gu, Kyoung Je Cha, Dong Sung Kim, Wan Kyun Chung
Surface electromyography (sEMG) signals reflect muscle contraction and hence, can provide information regarding a user's movement intention. High-density sEMG systems have been proposed to measure muscle activity in small areas and to estimate complex motion using spatial patterns. However, conventional systems based on wet electrodes have several limitations. For example, the electrolyte enclosed in wet electrodes restricts spatial resolution, and these conventional bulky systems limit natural movements. In this paper, a microneedle-based high-density electrode array on a circuit integrated flexible substrate for sEMG is proposed...
December 30, 2017: Sensors
https://www.readbyqxmd.com/read/29296482/in-vivo-studies-of-transdermal-nanoparticle-delivery-with-microneedles-using-photoacoustic-microscopy
#12
Mohesh Moothanchery, Razina Z Seeni, Chenjie Xu, Manojit Pramanik
Microneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the in vivo visualization of the delivery process. This study presents the utilization of optical resolution-photoacoustic microscopy to characterize the transdermal delivery of nanoparticles using microneedles. Specifically, we observe the in vivo transdermal delivery of gold nanoparticles using microneedles in mice ear and study the penetration, diffusion, and spatial distribution of the nanoparticles in the tissue...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29288358/an-update-on-coating-manufacturing-techniques-of-microneedles
#13
REVIEW
Tamara N Tarbox, Alan B Watts, Zhengrong Cui, Robert O Williams
Recently, results have been published for the first successful phase I human clinical trial investigating the use of dissolving polymeric microneedles… Even so, further clinical development represents an important hurdle that remains in the translation of microneedle technology to approved products. Specifically, the potential for accumulation of polymer within the skin upon repeated application of dissolving and coated microneedles, combined with a lack of safety data in humans, predicates a need for further clinical investigation...
December 29, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29288357/corneal-delivery-of-besifloxacin-using-rapidly-dissolving-polymeric-microneedles
#14
Shubhmita Bhatnagar, Amala Saju, Krishna Deepthi Cheerla, Sudeep Kumar Gade, Prashant Garg, Venkata Vamsi Krishna Venuganti
Penetration of antibiotics into and through the cornea is a major limiting factor in the treatment of ocular infections. Several strategies are in vogue to overcome this limitation such as use of fortified drops, gels, and subconjunctival injections. Here, we present the fabrication of rapidly dissolving polymeric microneedle array to effectively deliver besifloxacin through the cornea. Microneedles were prepared using polyvinyl alcohol and polyvinyl pyrrolidone by the micromolding technique. The model fluoroquinolone antibiotic, besifloxacin, was loaded in 36 microneedles arranged in a 6 × 6 array format within a 1 cm2 area...
December 29, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29283688/efficacy-of-protein-extracts-from-medium-of-adipose-derived-stem-cells-via-microneedles-on-asian-skin
#15
Xi Wang, Xiaohong Shu, Wei Huo, Lin Zou, Li Li
OBJECTIVES: To explore efficacy of protein extracts from medium of Adipose-derived stem cells (ADSCs) via microneedles on Asian skin in a double-blind, split-face, randomized, control study. METHODS: Thirty volunteers received the treatment, left-side and right-side of their face were randomly assigned to test side and control side. The protein extracts from medium of ADSCs were applied via microneedles into the test side and ultrapure water was applied into the control side...
December 28, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29273100/an-overview-of-the-biology-of-platelet-rich-plasma-and-microneedling-as-potential-treatments-for-alopecia-areata
#16
REVIEW
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for...
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29259264/skin-immunization-by-microneedle-patch-overcomes-statin-induced-suppression-of-immune-responses-to-influenza-vaccine
#17
Elena V Vassilieva, Shelly Wang, Song Li, Mark R Prausnitz, Richard W Compans
Recent studies indicated that in elderly individuals, statin therapy is associated with a reduced response to influenza vaccination. The present study was designed to determine effects on the immune response to influenza vaccination induced by statin administration in a mouse model, and investigate potential approaches to improve the outcome of vaccination on the background of statin therapy. We fed middle aged BALB/c mice a high fat "western" diet (WD) alone or supplemented with atorvastatin (AT) for 14 weeks, and control mice were fed with the regular rodent diet...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29258173/correction-development-of-novel-faster-dissolving-microneedle-patches-for-transcutaneous-vaccine-delivery-pharmaceutics-2017-9-3-27
#18
Akihiko Ono, Sayami Ito, Shun Sakagami, Hideo Asada, Mio Saito, Ying-Shu Quan, Fumio Kamiyama, Sachiko Hirobe, Naoki Okada
The authors wish to make a change to their published paper [1].[...].
December 18, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29249461/improving-vaccine-and-immunotherapy-design-using-biomaterials
#19
REVIEW
Michelle L Bookstaver, Shannon J Tsai, Jonathan S Bromberg, Christopher M Jewell
Polymers, lipids, scaffolds, microneedles, and other biomaterials are rapidly emerging as technologies to improve the efficacy of vaccines against infectious disease and immunotherapies for cancer, autoimmunity, and transplantation. New studies are also providing insight into the interactions between these materials and the immune system. This insight can be exploited for more efficient design of vaccines and immunotherapies. Here, we describe recent advances made possible through the unique features of biomaterials, as well as the important questions for further study...
November 15, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/29248845/bioinspired-microneedle-insertion-for-deep-and-precise-skin-penetration-with-low-force-why-the-application-of-mechanophysical-stimuli-should-be-considered
#20
Jonghun Kim, Sungmin Park, Gyungmok Nam, Young Choi, Seungpyo Woo, Sang-Hee Yoon
A mosquito is known to precisely and easily insert its proboscis to the human skin by pressing down a labium and vibrating a fascicle bundle. Its advanced skin-piercing mechanisms indicate that skin resistance to the insertion of needle-like objects can be changed by the application of mechanophysical stimuli. Here, we characterize the effect of the application of mechanophysical stimuli on skin resistance to microneedle insertion to find clues for inserting a microneedle in a deep and precise fashion with low force...
December 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
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