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https://www.readbyqxmd.com/read/28318091/insulin-responsive-glucagon-delivery-for-prevention-of-hypoglycemia
#1
Jicheng Yu, Yuqi Zhang, Wujin Sun, Anna R Kahkoska, Jinqiang Wang, John B Buse, Zhen Gu
Hypoglycemia, the state of abnormally low blood glucose level, is an acute complication of insulin and sulfonylurea therapy in diabetes management. Frequent insulin dosing and boluses during daily diabetes care leads to an increased risk of dangerously low glucose levels, which can cause behavioral and cognitive disturbance, seizure, coma, and even death. This study reports an insulin-responsive glucagon delivery method based on a microneedle (MN)-array patch for the prevention of hypoglycemia. The controlled release of glucagon is achieved in response to elevated insulin concentration by taking advantage of the specific interaction between insulin aptamer and target insulin...
March 20, 2017: Small
https://www.readbyqxmd.com/read/28292673/bioresponsive-transcutaneous-patches
#2
REVIEW
Jicheng Yu, Yuqi Zhang, Anna R Kahkoska, Zhen Gu
Transdermal drug delivery systems that utilize transcutaneous patches of arrayed microneedles have attracted increasing interest in medical practice as an alternative method to hypodermic injection. Over the past ten years, research has focused on leveraging physiological signals associated with diseases or skin-specific tissues to create bioresponsive patches that release drug directly in response to an internally-generated stimulus. This review surveys the recent advances in the development and use of bioresponsive transcutaneous patches for on-demand smart and precise drug delivery, exploiting different physiological signals including pH, serum glucose levels, and enzyme activity...
March 11, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28286864/in-vivo-expansion-of-melanoma-specific-t-cells-using-microneedle-arrays-coated-with-immune-polyelectrolyte-multilayers
#3
Qin Zeng, Joshua M Gammon, Lisa H Tostanoski, Yu-Chieh Chiu, Christopher M Jewell
Microneedles (MNs) are micron-scale polymeric or metallic structures that offer distinct advantages for vaccines by efficiently targeting skin-resident immune cells, eliminating injection-associated pain, and improving patient compliance. These advantages, along with recent studies showing therapeutic benefits achieved using traditional intradermal injections in human cancer patients, suggest MN delivery might enhance cancer vaccines and immunotherapies. We recently developed a new class of polyelectrolyte multilayers based on the self-assembly of model peptide antigens and molecular toll-like receptor agonists (TLRa) into ultrathin, conformal coatings...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28286315/formulation-of-hydrophobic-peptides-for-skin-delivery-via-coated-microneedles
#4
Xin Zhao, Sion A Coulman, Stephanie J Hanna, F Susan Wong, Colin M Dayan, James C Birchall
Microneedles (MNs) have been investigated as a minimally-invasive delivery technology for a range of active pharmaceutical ingredients (APIs). Various formulations and methods for coating the surface of MNs with therapeutics have been proposed and exemplified, predominantly for hydrophilic drugs and particulates. The development of effective MN delivery formulations for hydrophobic drugs is more challenging with dosing restrictions and the use of organic solvents impacting on both the bioactivity and the kinetics of drug release...
March 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28285849/erratum-to-combining-different-types-of-multifunctional-liposomes-loaded-with-ammonium-bicarbonate-to-fabricate-microneedle-arrays-as-a-vaginal-mucosal-vaccine-adjuvant-dual-delivery-system-vadds-j-control-release-246-2017-12-29
#5
Ning Wang, Yuanyuan Zhen, Yiguang Jin, Xueting Wang, Ning Li, Shaohong Jiang, Ting Wang
No abstract text is available yet for this article.
March 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28285193/tolerability-usability-and-acceptability-of-dissolving-microneedle-patch-administration-in-human-subjects
#6
Jaya Arya, Sebastien Henry, Haripriya Kalluri, Devin V McAllister, Winston P Pewin, Mark R Prausnitz
To support translation of microneedle patches from pre-clinical development into clinical trials, this study examined the effect of microneedle patch application on local skin reactions, reliability of use and acceptability to patients. Placebo patches containing dissolving microneedles were administered to fifteen human participants. Microneedle patches were well tolerated in the skin with no pain or swelling and only mild erythema localized to the site of patch administration that resolved fully within seven days...
March 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28275153/an-oral-microjet-vaccination-system-elicits-antibody-production-in-rabbits
#7
Kiana Aran, Marc Chooljian, Jacobo Paredes, Mohammad Rafi, Kunwoo Lee, Allison Y Kim, Jeanny An, Jennifer F Yau, Helen Chum, Irina Conboy, Niren Murthy, Dorian Liepmann
Noninvasive immunization technologies have the potential to revolutionize global health by providing easy-to-administer vaccines at low cost, enabling mass immunizations during pandemics. Existing technologies such as transdermal microneedles are costly, deliver drugs slowly, and cannot generate mucosal immunity, which is important for optimal immunity against pathogens. We present a needle-free microjet immunization device termed MucoJet, which is a three-dimensional microelectromechanical systems-based drug delivery technology...
March 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28269417/robot-assisted-retinal-vein-cannulation-with-force-based-puncture-detection-micron-vs-the-steady-hand-eye-robot
#8
Berk Gonenc, Nhat Tran, Peter Gehlbach, Russell H Taylor, Iulian Iordachita
Retinal vein cannulation is a demanding procedure where therapeutic agents are injected into occluded retina veins. The feasibility of this treatment is limited due to challenges in identifying the moment of venous puncture, achieving cannulation and maintaining it throughout the drug delivery period. In this study, we integrate a force-sensing microneedle with two distinct robotic systems: the handheld micromanipulator Micron, and the cooperatively controlled Steady-Hand Eye Robot (SHER). The sensed tool-to-tissue interaction forces are used to detect venous puncture and extend the robots' standard control schemes with a new position holding mode (PHM) that assists the operator hold the needle position fixed and maintain cannulation for a longer time with less trauma on the vasculature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268663/microneedle-cuff-electrodes-for-extrafascicular-peripheral-nerve-interfacing
#9
Yogi A Patel, Andrew Willsie, Isaac P Clements, Ricardo Aguilar, Swaminathan Rajaraman, Robert J Butera
OBJECTIVE: The work presented here describes a new tool for peripheral nerve interfacing, called the microneedle cuff (μN-cuff) electrode. APPROACH: μN arrays are designed and integrated into cuff electrodes for penetrating superficial tissues while remaining non-invasive to delicate axonal tracts. MAIN RESULTS: In acute testing, the presence of 75 μm height μNs decreased the electrode-tissue interface impedance by 0.34 kΩ, resulting in a 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28254630/hydrodynamic-gene-delivery-in-human-skin-using-a-hollow-microneedle-device
#10
M Dul, M Stefanidou, P Porta, J Serve, C O'Mahony, B Malissen, S Henri, Y Levin, E Kochba, F S Wong, C Dayan, S A Coulman, J C Birchall
Microneedle devices have been proposed as a minimally invasive delivery system for the intradermal administration of nucleic acids, both plasmid DNA (pDNA) and siRNA, to treat localised disease or provide vaccination. Different microneedle types and application methods have been investigated in the laboratory, but limited and irreproducible levels of gene expression have proven to be significant challenges to pre-clinical to clinical progression. This study is the first to explore the potential of a hollow microneedle device for the delivery and subsequent expression of pDNA in human skin...
February 27, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28240174/hormone-therapy-and-delivery-strategies-against-cardiovascular-diseases
#11
Gayathri Acharya, Nurhasni Hasan, Jin-Wook Yoo, Chi H Lee
This review article is aimed to delineate the potential role of hormones in the treatment and diagnosis of cardiovascular diseases with special emphasis on the nitric oxide (NO) involved mechanisms. This review will also offer an overview on current and future hormone usages, pathophysiology, clinical features, absorption mechanisms and adverse effects. The hormone therapies against cardiovascular diseases as well as their treatment strategies, delivery routes and carriers were thoroughly discussed. Ongoing and future basic and clinical research with hormone will provide important insights into efficient treatment strategies against cardiovascular diseases...
February 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28238142/glucose-responsive-insulin-delivery-by-microneedle-array-patches-loaded-with-hypoxia-sensitive-vesicles
#12
Jicheng Yu, Yuqi Zhang, Zhen Gu
In this chapter, we describe the preparation of glucose-responsive vesicles (GRVs) and the fabrication of GRV-loaded microneedle-array patches for insulin delivery. The GRVs were formed of hypoxia-sensitive hyaluronic acid (HS-HA), the synthesis of which is presented in detail. We also describe the procedure to evaluate the in vivo efficacy of this smart patch in a mouse model of chemically induced type 1 diabetes through transcutaneous administration.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28237913/pharmacodynamic-study-of-eprosartan-mesylate-loaded-transfersomes-carbopol-%C3%A2-gel-under-dermaroller-%C3%A2-on-rats-with-methyl-prednisolone-acetate-induced-hypertension
#13
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of present study was to prepare eprosartan mesylate (EM)-loaded transfersomes Carbopol(®) gel and characterized for various parameters, including in vitro skin permeation, in vivo antihypertensive study, skin irritation, and histological study. Furthermore, effect of transfersomes gel on angiotensin II type-1 receptor (AT1R) mRNA and protein expressions on smooth vascular muscles of aorta was determined by real-time polymerase chain reaction (RT-PCR) and western blot analysis. The physical evaluation parameters were detected to be in correspondence with reference marketed gel formulation...
February 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28227660/robot-assisted-retinal-vein-cannulation-with-force-based-puncture-detection-micron-vs-the-steady-hand-eye-robot
#14
Berk Gonenc, Nhat Tran, Peter Gehlbach, Russell H Taylor, Iulian Iordachita, Berk Gonenc, Nhat Tran, Peter Gehlbach, Russell H Taylor, Iulian Iordachita, Nhat Tran, Russell H Taylor, Iulian Iordachita, Berk Gonenc, Peter Gehlbach
Retinal vein cannulation is a demanding procedure where therapeutic agents are injected into occluded retina veins. The feasibility of this treatment is limited due to challenges in identifying the moment of venous puncture, achieving cannulation and maintaining it throughout the drug delivery period. In this study, we integrate a force-sensing microneedle with two distinct robotic systems: the handheld micromanipulator Micron, and the cooperatively controlled Steady-Hand Eye Robot (SHER). The sensed tool-to-tissue interaction forces are used to detect venous puncture and extend the robots' standard control schemes with a new position holding mode (PHM) that assists the operator hold the needle position fixed and maintain cannulation for a longer time with less trauma on the vasculature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226847/microneedle-cuff-electrodes-for-extrafascicular-peripheral-nerve-interfacing
#15
Yogi A Patel, Andrew Willsie, Isaac P Clements, Ricardo Aguilar, Swaminathan Rajaraman, Robert J Butera, Yogi A Patel, Andrew Willsie, Isaac P Clements, Ricardo Aguilar, Swaminathan Rajaraman, Robert J Butera, Ricardo Aguilar, Robert J Butera, Swaminathan Rajaraman, Yogi A Patel, Andrew Willsie, Isaac P Clements
OBJECTIVE: The work presented here describes a new tool for peripheral nerve interfacing, called the microneedle cuff (μN-cuff) electrode. APPROACH: μN arrays are designed and integrated into cuff electrodes for penetrating superficial tissues while remaining non-invasive to delicate axonal tracts. MAIN RESULTS: In acute testing, the presence of 75 μm height μNs decreased the electrode-tissue interface impedance by 0.34 kΩ, resulting in a 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220163/a-microneedle-biosensor-for-minimally-invasive-transdermal-detection-of-nerve-agents
#16
Rupesh K Mishra, A M Vinu Mohan, Fernando Soto, Robert Chrostowski, Joseph Wang
A microneedle electrochemical biosensor for the minimally invasive detection of organophosphate (OP) chemical agents is described. The new sensor relies on the coupling of the effective biocatalytic action of organophosphorus hydrolase (OPH) with a hollow-microneedle modified carbon-paste array electrode transducer, and involves rapid square-wave voltammetric (SWV) measurements of the p-nitrophenol product of the OPH enzymatic reaction in the presence of the OP substrate. The scanning-potential SWV transduction mode offers an additional dimension of selectivity compared to common fixed-potential OPH-amperometric biosensors...
March 13, 2017: Analyst
https://www.readbyqxmd.com/read/28217546/microneedles-mediated-drug-and-vaccine-delivery
#17
EDITORIAL
Upendra Nagaich
No abstract text is available yet for this article.
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28216463/successful-application-of-large-microneedle-patches-by-human-volunteers
#18
Anastasia Ripolin, James Quinn, Eneko Larrañeta, Eva Maria Vicente-Perez, Johanne Barry, Ryan F Donnelly
We describe, for the first time, the design, production and evaluation of large microneedle patches. Such systems, based on 16 individual microneedle arrays (needle height 600μm), were prepared from aqueous blends of 15% w/w Gantrez(®) S97 and 7.5% w/w poly(ethyleneglycol) 10,000Da. Ester-based crosslinking was confirmed by FTIR and mechanical strength was good. Insertion depths in a validated skin model were approximately 500μm. Ten human volunteers successfully self-inserted the microneedles of these larger patches in their skin, following appropriate instruction, as confirmed by transepidermal water loss measurements...
February 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28215667/microneedle-bio-microneedle-and-bio-inspired-microneedle-a-review
#19
REVIEW
Guojun Ma, Chengwei Wu
Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows them with many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs. The objective of this review is mainly to introduce studies on the mechanics problems with respect to MNs. Firstly, the basic knowledge of MNs is introduced in brief, so that readers can understand the basic characteristics of MNs...
February 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28199493/aesthetic-and-functional-improvement-of-chronic-radiation-dermatitis-with-noninsulated-microneedle-fractional-radiofrequency
#20
Derek Ho, Ekaterina Kraeva, Joshua M Schulman, Jared Jagdeo
No abstract text is available yet for this article.
February 15, 2017: JAMA Dermatology
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