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https://www.readbyqxmd.com/read/28095556/combination-therapy-for-acne-scarring-personal-experience-and-clinical-suggestions
#1
Lucija Kroepfl, Jason J Emer
Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095540/multi-center-pilot-study-to-evaluate-the-safety-pro-le-of-high-energy-fractionated-radiofrequency-with-insulated-microneedles-to-multiple-levels-of-the-dermis
#2
Joel L Cohen, Steven F Weiner, Jason N Pozner, Omar A Ibrahimi, David B Vasily, E Victor Ross, Zena Gabriel
In this multi-center pilot study, the safety pro le of high intensity focused radiofrequency (RF) delivered to the dermis was evaluated for safety in the treatment of the aging neck and face. A newly designed insulated microneedle system delivers a signi cant coagulative thermal injury into the dermis while sparing the epidermis from RF injury. Thirty- ve healthy subjects from seven aesthetic practices were evaluated, and data from each were incorporated in this case report. The subjects received a single treatment using settings that delivered the highest RF energies suggested from the new recommended protocols...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28089998/first-clinical-experience-with-targeted-renal-nerve-demodulation-trend-1-using-a-neurotropic-agent-for-the-treatment-of-sympathetic-hypertension
#3
Nicholas Kipshidze, Horst Sievert, Michael H Wholey, Konstantin Kipiani, Vakhtang Kipiani, Tea Mukhuradze, Mark Wholey, Emily Stein, K T Venkateswara Rao
AIMS: To evaluate the feasibility and safety of a novel targeted neuromodulatory treatment for sympathetic hypertension involving a one-time local injection of neurotropic agents near renal nerves. METHODS AND RESULTS: Seven patients suffering from uncontrolled hypertension per ESH-ESC guidelines were treated using a single dose of NW2013, a neurotropic Na+/K+ ATPase antagonist. A microneedle catheter was used to administer 1.2 mL of NW2013 (0.6 mL per artery) to the perivascular space surrounding renal arteries using percutaneous endovascular procedures under fluoroscopic guidance...
January 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28088750/continuous-minimally-invasive-alcohol-monitoring-using-microneedle-sensor-arrays
#4
A M Vinu Mohan, Joshua Ray Windmiller, Rupesh K Mishra, Joseph Wang
The present work describes an attractive skin-worn microneedle sensing device for the minimally invasive electrochemical monitoring of subcutaneous alcohol. The device consists of an assembly of pyramidal microneedle structures integrated with Pt and Ag wires, each with a microcavity opening. The microneedle aperture was modified by electropolymerizing o-phenylene diamine onto the Pt wire microtransducer, followed by the immobilization of alcohol oxidase (AOx) in an intermediate chitosan layer, along with an outer Nafion layer...
January 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28087654/effects-of-external-strain-on-the-regulation-of-microtubule-sliding-induced-by-outer-arm-dynein-of-sea-urchin-sperm-flagella
#5
Hiroshi Yoke, Chikako Shingyoji
Oscillatory bending movement of eukaryotic flagella is powered by orchestrated activity of dynein motor proteins that hydrolyze ATP and produce microtubule sliding. Although the ATP concentration within a flagellum is kept uniform at a few mmol l(-1) level, sliding activities of dyneins are dynamically coordinated along the flagellum in accordance with the phase of bending waves. Thus, at the organellar level the dynein not only generates force for bending but also modulates its motile activity by responding to bending of the flagellum...
January 13, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28079384/hypoxia-and-h2o2-dual-sensitive-vesicles-for-enhanced-glucose-responsive-insulin-delivery
#6
Jicheng Yu, Chenggen Qian, Yuqi Zhang, Zheng Cui, Yong Zhu, Qundong Shen, Frances S Ligler, John B Buse, Zhen Gu
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive insulin delivery device using a painless microneedle-array patch containing insulin-loaded vesicles. Formed by self-assembly of hypoxia and H2O2 dual-sensitive diblock copolymer, the glucose-responsive polymersome-based vesicles (d-GRPs) can disassociate and subsequently release insulin triggered by H2O2 and hypoxia generated during glucose oxidation catalyzed by glucose specific enzyme...
January 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28078629/effect-of-microneedle-type-on-transdermal-permeation-of-rizatriptan
#7
Chandrateja Uppuluri, Ashraf Sultana Shaik, Tao Han, Atul Nayak, Karthik J Nair, Benjamin R Whiteside, Buchi N Nalluri, Diganta B Das
The present study was aimed to investigate the effect of salient microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation of rizatriptan (RIZ). Studies were carried out using two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 0.9, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PMs) of 0.6 mm length. In the case of the PMs, arrays were applied three times at different places within a 1.77-cm(2) skin area (PM-3) to maintain the MN density closer to 0...
January 11, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28075069/ebola-vaccination-using-a-dna-vaccine-coated-on-plga-pll-%C3%AE-pga-nanoparticles-administered-using-a-microneedle-patch
#8
Hung-Wei Yang, Ling Ye, Xin Dong Guo, Chinglai Yang, Richard W Compans, Mark R Prausnitz
Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
January 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28071597/three-dimensional-printing-of-a-microneedle-array-on-personalized-curved-surfaces-for-dual-pronged-treatment-of-trigger-finger
#9
Seng Han Lim, Jian Yao Ng, Lifeng Kang
The hand function of patients who suffer from trigger finger can be impaired by the use of traditional splints. There is also a risk of systemic side effects with oral non-steroidal anti-inflammatory drugs (NSAIDs) used for pain relief. Microneedle-assisted transdermal drug delivery offers an attractive alternative for local delivery of NSAIDs. However, traditional microneedle arrays fabricated on flat surfaces are unable to deliver drugs effectively across the undulating skin surface of affected finger(s)...
January 10, 2017: Biofabrication
https://www.readbyqxmd.com/read/28070698/drug-coated-microneedles-for-rapid-and-painless-local-anesthesia
#10
Sung-Hyun Baek, Ju-Hyung Shin, Yeu-Chun Kim
This study showed that drug-coated PLLA (Poly (L-lactide)) microneedle arrays can induce rapid and painless local anesthesia. Microneedle arrays were fabricated using a micro-molding technique, and the needle tips were coated with 290.6 ± 45.9 μg of lidocaine, the most widely used local anesthetic worldwide. A dip-coating device was newly designed for the coating step using an optimized coating formulation. Lidocaine coated on the arrays was released rapidly into PBS within 2 min, and its stability in storage lasted 3 weeks at 4, 25, and 37°C...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28068767/microneedle-assisted-skin-permeation-by-non-toxic-bioengineerable-gas-vesicle-nanoparticles
#11
Abhay U Andar, Ram Karan, Wolf T Pecher, Priya DasSarma, William D Hedrich, Audra L Stinchcomb, Shiladitya DasSarma
Gas vesicle nanoparticles (GVNPs) are hollow, buoyant protein organelles produced by the extremophilic microbe Halobacterium sp. NRC-1 and are being developed as bioengineerable and biocompatible antigen and drug-delivery systems (DDS). Dynamic light scattering measurements of purified GVNP suspensions showed a mean diameter of 245 nm. In vitro diffusion studies using Yucatan miniature pig skin showed GVNP permeation to be enhanced after MN-treatment compared to untreated skin. GVNPs were found to be non-toxic to mammalian cells (human kidney and rat mycocardial myoblasts)...
January 9, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28057546/in-vitro-and-in-vivo-evaluation-of-a-hydrogel-based-microneedle-device-for-transdermal-electro-modulated-analgesia
#12
Sunaina Indermun, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Girish Modi, Regina Luttge, Mershen Govender, Viness Pillay
With a significant portion of the world suffering from chronic pain, the management and treatment of this condition still requires extensive research to successfully mobilize and functionalize its sufferers. This paper details the in vitro and in vivo evaluation of a transdermal Electro-Modulated Hydrogel- Microneedle array (EMHM) device for the treatment of chronic pain. In vitro characterization of the Electro-Modulated Hydrogel was undertaken prior to the determination of the in vivo release, histopathological and pharmacokinetic profiles of the EMHM in a Sprague Dawley rat model...
January 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28051306/h2o2-responsive-vesicles-integrated-with-transcutaneous-patches-for-glucose-mediated-insulin-delivery
#13
Xiuli Hu, Jicheng Yu, Chenggen Qian, Yue Lu, Anna R Kahkoska, Zhigang Xie, Xiabin Jing, John B Buse, Zhen Gu
A self-regulated "smart" insulin administration system would be highly desirable for diabetes management. Here, a glucose-responsive insulin delivery device, which integrates H2O2-responsive polymeric vesicles (PVs) with a transcutaneous microneedle-array patch was prepared to achieve a fast response, excellent biocompatibility, and painless administration. The PVs are self-assembled from block copolymer incorporated with polyethylene glycol (PEG) and phenylboronic ester (PBE)-conjugated polyserine (designated mPEG-b-P(Ser-PBE)) and loaded with glucose oxidase (GOx) and insulin...
January 4, 2017: ACS Nano
https://www.readbyqxmd.com/read/28009691/treatment-of-acne-scars-on-darker-skin-types-using-a-noninsulated-smooth-motion-electronically-controlled-radiofrequency-microneedles-treatment-system
#14
David Pudukadan
BACKGROUND: Noninvasive technologies for treating acne scars use radiofrequency (RF)-emitting microneedles for both mechanical disruption of fibrotic strands and heat-mediated collagen remodeling. OBJECTIVE: Efficacy and safety evaluation of electronically controlled noninsulated RF microneedling system on acne scars in patients with dark skin. METHODS: Nineteen patients, 24 to 51 years old, skin types III to V, with acne scars were enrolled in the study...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28009690/fractional-erbium-doped-yttrium-aluminum-garnet-laser-versus-microneedling-in-treatment-of-atrophic-acne-scars-a-randomized-split-face-clinical-study
#15
Mai Abdel Raouf Osman, Hisham Ali Shokeir, Marwa M Fawzy
BACKGROUND: Ablative fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser and microneedling have been popularized in recent years and their effectiveness and side effects individually reported. No previous study, however, has directly compared the efficacy and safety between the 2 different treatments. OBJECTIVE: To compare the efficacy and safety of the ablative fractional Er:YAG laser and microneedling for the treatment of atrophic acne scars. MATERIALS AND METHODS: Thirty patients with atrophic acne scars were randomly treated in a split-face manner with a fractional Er:YAG laser on one side and microneedling on the other side...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28006012/potential-cost-effectiveness-of-an-influenza-vaccination-program-offering-microneedle-patch-for-vaccine-delivery-in-children
#16
Carlos Wong, Minghuan Jiang, Joyce H S You
OBJECTIVE: The influenza vaccine coverage rate of children is low in Hong Kong. Microneedle patches (MNPs) is a technology under development for painless delivery of vaccines. This study aimed to examine the potential clinical outcomes and direct medical costs of an influenza program offering MNP vaccine to children who have declined intramuscular (IM) vaccine in Hong Kong. METHODS: A decision model was designed to compare potential outcomes between IM vaccine program and a program offering MNP vaccine to those declined IM vaccine (IM/MNP program) in a hypothetical cohort of children over one-year time horizon...
2016: PloS One
https://www.readbyqxmd.com/read/28005627/needling-assisted-drug-delivery-enhanced-response-to-ingenol-mebutate-after-microneedling
#17
Stephan A Braun, Peter A Gerber, Peter A Hevezi
No abstract text is available yet for this article.
December 21, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28001346/analgesic-microneedle-patch-for-neuropathic-pain-therapy
#18
Xi Xie, Conrado Pascual, Christopher Lieu, Seajin Oh, Ji Wang, Bende Zou, Julian Xie, Zhaohui Li, James Xie, David C Yeomans, Mei X Wu, Xinmin Simon Xie
Neuropathic pain caused by nerve injury is debilitating and difficult to treat. Current systemic pharmacological therapeutics for neuropathic pain produce limited pain relief and have undesirable side effects, while current local anesthetics tend to nonspecifically block both sensory and motor functions. Calcitonin gene related peptide (CGRP), a neuropeptide released from sensory nerve endings, appears to play a significant role in chronic neuropathic pain. In this study, an analgesic microneedle (AMN) patch was developed using dissolvable microneedles to transdermally deliver selective CGRP antagonist peptide in a painless manner for the treatment of localized neuropathic pain...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27987766/fabrication-of-biodegradable-composite-microneedles-based-on-calcium-sulfate-and-gelatin-for-transdermal-delivery-of-insulin
#19
Weijiang Yu, Guohua Jiang, Depeng Liu, Lei Li, Hua Chen, Yongkun Liu, Qin Huang, Zaizai Tong, Juming Yao, Xiangdong Kong
To reduce the inconvenience and pain of subcutaneous needle injection, the calcium sulfate and gelatin biodegradable composite microneedle patches with high aspect-ratio microneedles (MNs) and a flexible substrate have been developed. The microneedles with an aspect-ratio approximate 6:1 exhibit excellent mechanical property which can achieve 0.4N for each needle. The cross-section views show the inside of microneedles that have abundant pores and channels which offer potential for different drug-release profiles...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27986552/combining-different-types-of-multifunctional-liposomes-loaded-with-ammonium-bicarbonate-to-fabricate-microneedle-arrays-as-a-vaginal-mucosal-vaccine-adjuvant-dual-delivery-system-vadds
#20
Ning Wang, Yuanyuan Zhen, Yiguang Jin, Xueting Wang, Ning Li, Shaohong Jiang, Ting Wang
To develop effective mucosal vaccines, two types of multifunctional liposomes, the mannosylated lipid A-liposomes (MLLs) with a size of 200nm and the stealth lipid A-liposomes (SLLs) of 50nm, both loaded with a model antigen and NH4HCO3, were fabricated together into microneedles, forming the proSLL/MLL-constituted microneedle array (proSMMA), which upon rehydration dissolved rapidly recovering the initial MLLs and SLLs. Mice vaccinated with proSMMAs by vaginal mucosa patching other than conventional intradermal administration established robust antigen-specific humoral and cellular immunity at both systemic and mucosal levels, especially, in the reproductive and intestinal ducts...
December 13, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
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