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https://www.readbyqxmd.com/read/28929244/analyzing-polymeric-matrix-for-fabrication-of-a-biodegradable-microneedle-array-to-enhance-transdermal-delivery
#1
Kuo-Yuan Hwa, Vincent H S Chang, Yao-Yi Cheng, Yue-Da Wang, Pey-Shynan Jan, Boopathi Subramani, Min-Ju Wu, Bo-Kai Wang
Traditional drug delivery systems, using invasive, transdermal, and oral routes, are limited by various factors, such as the digestive system environment, skin protection, and sensory nerve stimulation. To improve the drug delivery system, we fabricated a polysaccharide-based, dissolvable microneedle-based array, which combines the advantages of both invasive and transdermal delivery systems, and promises to be an innovative solution for minimally invasive drug delivery. In this study, we designed a reusable aluminum mold that greatly improved the efficiency and convenience of microneedle fabrication...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28919324/pretreatment-of-skin-using-an-abrasive-skin-preparation-pad-a-microneedling-device-or-iontophoresis-improves-absorption-of-methyl-aminolevulinate-in-ex-vivo-human-skin
#2
Hanan Osman-Ponchet, Alexandre Gaborit, Karine Sevin, Christophe Bianchi, Jean-Michel Linget, Claire E Wilson, Guy Bouvier
BACKGROUND: Pretreatment of skin to remove scales/crusts and roughen the surface is essential to enhance the penetration of topically applied methyl aminolevulinate (MAL) prior to photodynamic therapy and to permit daylight to access all parts of the skin lesions. Numerous procedures of skin preparation are currently available. This study compared the in vitro penetration of MAL into ex vivo human skin pretreated with skin preparation pad abrasion or a microneedling device, and evaluated the effectiveness of an iontophoretic device in delivering MAL into ex vivo human skin...
September 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28919029/recent-advances-of-controlled-drug-delivery-using-microfluidic-platforms
#3
REVIEW
Sharma T Sanjay, Wan Zhou, Maowei Dou, Hamed Tavakoli, Lei Ma, Feng Xu, XiuJun Li
Conventional systematically-administered drugs distribute evenly throughout the body, get degraded and excreted rapidly while crossing many biological barriers, leaving minimum amounts of the drugs at pathological sites. Controlled drug delivery aims to deliver drugs to the target sites at desired rates and time, thus enhancing the drug efficacy, pharmacokinetics, and bioavailability while maintaining minimal side effects. Due to a number of unique advantages of the recent microfluidic lab-on-a-chip technology, microfluidic lab-on-a-chip has provided unprecedented opportunities for controlled drug delivery...
September 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28917531/hollow-microneedle-mediated-intradermal-delivery-of-model-vaccine-antigen-loaded-plga-nanoparticles-elicits-protective-t-cell-mediated-immunity-to-an-intracellular-bacterium
#4
Anne Marit de Groot, Guangsheng Du, Juha Mönkäre, Anouk C M Platteel, Femke Broere, Joke A Bouwstra, Alice J A M Sijts
The skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles with and without TLR3 agonist poly(I:C) were prepared and administered intradermally by hollow microneedles. The capacity of the PLGA nanoparticles to induce a cytotoxic T cell response, contributing to protection against intracellular pathogens, was examined...
September 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28916492/overcoming-ocular-drug-delivery-barriers-through-the-use-of-physical-forces
#5
Di Huang, Ying-Shan Chen, Ilva D Rupenthal
Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular drug delivery. While ocular barriers naturally have a protective function, they also limit drug entry into the eye. Various pharmaceutical strategies, such as novel formulations and physical force-based techniques, have been investigated to weaken these barriers and transport therapeutic agents effectively to both the anterior and the posterior segments of the eye. This review summarizes and discusses the recent research progress in the field of ocular drug delivery with a focus on the application of physical methods, including electrical fields, sonophoresis, and microneedles, which can enhance penetration efficiency by transiently disrupting the ocular barriers in a minimally or non-invasive manner...
September 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28915391/hepatitis-b-surface-antigen-incorporated-in-dissolvable-microneedle-array-patch-is-antigenic-and-thermostable
#6
Danielle Poirier, Frédéric Renaud, Vincent Dewar, Laurent Strodiot, Florence Wauters, Jim Janimak, Toshio Shimada, Tatsuya Nomura, Koki Kabata, Koji Kuruma, Takayuki Kusano, Masaki Sakai, Hideo Nagasaki, Takayoshi Oyamada
Alternatives to syringe-based administration are considered for vaccines. Intradermal vaccination with dissolvable microneedle arrays (MNA) appears promising in this respect, as an easy-to-use and painless method. In this work, we have developed an MNA patch (MNAP) made of hydroxyethyl starch (HES) and chondroitin sulphate (CS). In swines, hepatitis B surface antigen (HBsAg) formulated with the saponin QS-21 as adjuvant, both incorporated in HES-based MNAP, demonstrated the same level of immunogenicity as a commercially available aluminum-adjuvanted HBsAg vaccine, after two immunizations 28 days apart...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28914527/locally-induced-adipose-tissue-browning-by-microneedle-patch-for-obesity-treatment
#7
Yuqi Zhang, Qiongming Liu, Jicheng Yu, Shuangjiang Yu, Jinqiang Wang, Li Qiang, Zhen Gu
Obesity is one of the most serious public health problems in the 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current treatments toward obesity including diet, physical exercise, pharmacological therapy, as well as surgeries are always associated with low effectiveness or undesired systematical side effects. In order to enhance treatment efficiency with minimized side effects, we developed a transcutaneous browning agent patch to locally induce adipose tissue transformation...
September 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28902020/ensuring-consistent-results-when-microneedling-perioral-rhytides
#8
Adele Haimovic, Omer Ibrahim, Nicole Y Lee, Jeffrey S Dover
No abstract text is available yet for this article.
September 8, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28899209/microneedle-mediated-transdermal-delivery-of-nanostructured-lipid-carriers-for-alkaloids-from-aconitum-sinomontanum
#9
Teng Guo, Yongtai Zhang, Zhe Li, Jihui Zhao, Nianping Feng
A combination method using microneedle (MN) pretreatment and nanostructured lipid carriers (NLCs) was developed to improve the transdermal delivery of therapeutics. The MN treatment of the skin and co-administration of NLCs loaded with total alkaloids isolated from Aconitum sinomontanum (AAS-NLCs) significantly increased the skin permeation of the drugs. Fluorescence imaging confirmed that MNs could provide microchannels penetrating the stratum corneum, and delivery of NLCs through the channels led to their deeper permeation...
September 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28892233/hyaluronic-acid-microneedle-patch-for-the-improvement-of-crow-s-feet-wrinkles
#10
Sun Young Choi, Hyun Jung Kwon, Ga Ram Ahn, Eun Jung Ko, Kwang Ho Yoo, Beom Joon Kim, Changjin Lee, Daegun Kim
Hyaluronic acid (HA) has an immediate volumizing effect, due to its strong water-binding potential, and stimulates fibroblasts, causing collagen synthesis, with short- and long-term effects on wrinkle improvement. We investigated the efficacy and safety of HA microneedle patches for crow's feet wrinkles. Using a randomized spilt-face design, we compared microneedle patches with a topical application containing the same active ingredients. We enrolled 34 Korean female subjects with mild to moderate crow's feet wrinkles...
September 11, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28890214/effect-of-zymosan-and-poly-i-c-adjuvants-on-responses-to-microneedle-immunization-coated-with-whole-inactivated-influenza-vaccine
#11
Ju-Hyung Shin, Jin-Yong Noh, Kwon-Ho Kim, Jae-Keun Park, Ji-Ho Lee, Seong Dong Jeong, Dae-Yoon Jung, Chang-Seon Song, Yeu-Chun Kim
Microneedles are the micrometer size devices used for the delivery of vaccines and biotherapeutics. In order to increase the vaccine efficacy and reduce the antigen dose, there is a significant need to find some adjuvants for the microneedle vaccination. In this study, zymosan, which is the cell wall preparation of Saccharomyces cerevisiae, or poly (I:C) was coated on a microneedle with inactivated influenza virus, and then immunized into BALB/c mouse to determine the immunogenicity, protection and synergetic effect between two adjuvants...
September 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28881348/accelerating-topical-anaesthesia-using-microneedles
#12
Lleucu B Davies, Christopher Gateley, Phillip Holland, Siôn A Coulman, James C Birchall
BACKGROUND/AIMS: Topical anaesthetics reduce pain during venous access procedures in children. However, clinical use is hindered by a significant anaesthetic onset time. Restricted diffusion of the topical anaesthetic through the stratum corneum barrier is the principal reason for the delayed onset. Microneedles can painlessly pierce the skin. This study evaluated microneedle pre-treatment of ex vivo human skin as a means to increase the rate of tetracaine permeation, in order to accelerate the onset of anaesthesia...
September 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28877153/drug-delivery-after-microneedling-report-of-an-adverse-reaction
#13
Ana Paula Cercal Fucci-da-Costa, Helena Reich Camasmie
No abstract text is available yet for this article.
September 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28869385/microneedling-a-form-of-collagen-induction-therapy-our-first-experiences
#14
H Šuca, R Zajíček, Z Vodsloň
INTRODUCTION: Microneedling (percutaneous collagen induction therapy) is a new promising miniinvasive therapeutic method for the treatment of skin alterations of different aetiology, including burn scars. Since 2016, it is also available at our department. The microtraumatization of scars with the Dermaroller® leads to an activation of the healing cascade, activation of growth factors, which activate cell proliferation in the wound, increased synthesis and deposit of collagen - elastin complex with successive transformation of collagen III to collagen I, to neoangiogenesis and thus to accelerated scar remodelling...
2017: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/28868824/comparison-of-glucose-area-under-the-curve-measured-using-minimally-invasive-interstitial-fluid-extraction-technology-with-continuous-glucose-monitoring-system-in-diabetic-patients
#15
Mei Uemura, Yutaka Yano, Toshinari Suzuki, Taro Yasuma, Toshiyuki Sato, Aya Morimoto, Samiko Hosoya, Chihiro Suminaka, Hiromu Nakajima, Esteban C Gabazza, Yoshiyuki Takei
BACKGROUND: Continuous glucose monitoring (CGM) is reported to be a useful technique, but difficult or inconvenient for some patients and institutions. We are developing a glucose area under the curve (AUC) monitoring system without blood sampling using a minimally invasive interstitial fluid extraction technology (MIET). Here we evaluated the accuracy of interstitial fluid glucose (IG) AUC measured by MIET in patients with diabetes for an extended time interval and the potency of detecting hyperglycemia using CGM data as a reference...
August 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28867811/development-and-evaluation-of-topical-gabapentin-formulations
#16
Christopher J Martin, Natalie Alcock, Sarah Hiom, James C Birchall
Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol(®) hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm(®) formulation; furthermore microneedle facilitated delivery was used as a positive control...
August 30, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28867296/device-assisted-transdermal-drug-delivery
#17
Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
Transdermal drug delivery is a prospective drug delivery strategy to complement the limitations of conventional drug delivery systems including oral and injectable methods. This delivery route allows both convenient and painless drug delivery and a sustained release profile with reduced side effects. However, physiological barriers in the skin undermine the delivery efficiency of conventional patches, limiting drug candidates to small-molecules and lipophilic drugs. Recently, transdermal drug delivery technology has advanced from unsophisticated methods simply relying on natural diffusion to drug releasing systems that dynamically respond to external stimuli...
September 1, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28866156/polymer-microneedles-fabricated-from-alginate-and-hyaluronate-for-transdermal-delivery-of-insulin
#18
Weijiang Yu, Guohua Jiang, Yang Zhang, Depeng Liu, Bin Xu, Junyi Zhou
To reduce the inconvenient and painful of subcutaneous needle injection, the polymer microneedle patches that fabricated from modified alginate and hyaluronate were prepared for transdermal delivery of insulin. The as-prepared microneedles (MNs) exhibited excellent mechanical strength to penetrate the skin and good degradability to release loaded insulin. In vitro skin insertion capability was determined by staining with tissue-marking dye after insertion, and the real-time penetration depth was monitored using optical coherence tomography...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865105/minimally-invasive-and-targeted-therapeutic-cell-delivery-to-the-skin-using-microneedle-devices
#19
B Gualeni, S A Coulman, D Shah, P F Eng, H Ashraf, P Vescovo, G J Blayney, L-D Piveteau, O J Guy, J C Birchall
BACKGROUND: Translation of cell therapies to the clinic is accompanied by numerous challenges, including controlled and targeted delivery of the cells to their site of action, without compromising cell viability and functionality. OBJECTIVES: To explore the use of hollow microneedle devices (to date only used for the delivery of drugs and vaccines into the skin and for the extraction of biological fluids) to deliver cells into skin in a minimally-invasive, user-friendly and targeted fashion...
September 2, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28858169/microneedling-in-dermatology-a-review
#20
Kathryn Konicke, Michael Knabel, Edit Olasz
No abstract text is available yet for this article.
July 2017: Plastic Surgical Nursing
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