keyword
MENU ▼
Read by QxMD icon Read
search

microneedles

keyword
https://www.readbyqxmd.com/read/29160824/microneedle-assisted-percutaneous-delivery-of-a-tetramethylpyrazine-loaded-microemulsion
#1
Qiang Zu, Yanyan Yu, Xiaolin Bi, Ren Zhang, Liuqing Di
This study examined the efficacy of the percutaneous delivery of a tetramethylpyrazine-loaded microemulsion (TMP-ME) on skin pretreated with microneedles (MN). The TMP-ME formulation was optimized in vitro with skin permeation experiments, using a uniform experimental design, guided by a pseudo-ternary phase diagram, in which the TMP skin permeation level and mean particle size were indices. The effects of MN pretreatment on skin permeation by TMP-ME were assessed using in vitro skin permeation, in vivo skin microdialysis, and pharmacokinetic studies in rats...
November 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29159513/molybdenum-coated-su-8-microneedle-electrodes-for-transcutaneous-electrical-nerve-stimulation
#2
Ramin Soltanzadeh, Elnaz Afsharipour, Cyrus Shafai, Neda Anssari, Behzad Mansouri, Zahra Moussavi
Electrophysiological devices are connected to the body through electrodes. In some applications, such as nerve stimulation, it is needed to minimally pierce the skin and reach the underneath layers to bypass the impedance of the first layer called stratum corneum. In this study, we have designed and fabricated surface microneedle electrodes for applications such as electrical peripheral nerve stimulation. We used molybdenum for microneedle fabrication, which is a biocompatible metal; it was used for the conductive layer of the needle array...
November 21, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29154976/microneedle-arrays-coated-with-charge-reversal-ph-sensitive-copolymers-improve-antigen-presenting-cells-homing-dna-vaccine-delivery-and-immune-responses
#3
Huu Thuy Trang Duong, Nak Won Kim, Thavasyappan Thambi, V H Giang Phan, Min Sang Lee, Yue Yin, Ji Hoon Jeong, Doo Sung Lee
Successful delivery of a DNA vaccine to antigen-presenting cells and their subsequent stimulation of CD4(+) and CD8(+) T cell immunity remains an inefficient process. In general, the delivery of prophylactic vaccines is mainly mired by low transfection efficacy, poor immunogenicity, and safety issues from the materials employed. Currently, several strategies have been exploited to improve immunogenicity, but an effective strategy for safe and pain-free delivery of DNA vaccines is complicated. Herein, we report the rapid delivery of polyplex-based DNA vaccines using microneedle arrays coated with a polyelectrolyte multilayer assembly of charge reversal pH-responsive copolymer and heparin...
November 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29139187/pharmacokinetics-and-safety-of-paclitaxel-delivery-into-porcine-airway-walls-by-a-new-endobronchial-drug-delivery-catheter
#4
Hisashi Tsukada, Plamena Entcheva-Dimitrov, Armin Ernst, Samaan Rafeq, John H Keating, Kirk P Seward, Lonny Yarmus
BACKGROUND AND OBJECTIVE: Intratumoral administration of chemotherapeutic agents is a treatment modality that has proven efficacious in reducing the recurrence of tumours and increases specificity of treatment while minimizing systemic side effects. Direct intratumoral injection of malignant airway obstruction has potential therapeutic benefits but tissue drug concentrations and side-effect profiles are poorly understood. METHODS: Bronchial wall injection of generic paclitaxel (PTX) (102 injections of 0...
November 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29127107/heating-up-cancer-vaccines
#5
REVIEW
Saba Ghassemi, Beatriz M Carreno
A microneedle patch containing melanin promotes systemic antitumor response upon photothermal irradiation.
November 10, 2017: Science Immunology
https://www.readbyqxmd.com/read/29127106/a-melanin-mediated-cancer-immunotherapy-patch
#6
Yanqi Ye, Chao Wang, Xudong Zhang, Quanyin Hu, Yuqi Zhang, Qi Liu, Di Wen, Joshua Milligan, Adriano Bellotti, Leaf Huang, Gianpietro Dotti, Zhen Gu
Melanin is capable of transforming 99.9% of the absorbed sunlight energy into heat, reducing the risk of skin cancer. We here develop a melanin-mediated cancer immunotherapy strategy through a transdermal microneedle patch. B16F10 whole tumor lysate containing melanin is loaded into polymeric microneedles that allow sustained release of the lysate upon insertion into the skin. In combination with the near-infrared light irradiation, melanin in the patch mediates the generation of heat, which further promotes tumor-antigen uptake by dendritic cells, and leads to enhanced antitumor vaccination...
November 10, 2017: Science Immunology
https://www.readbyqxmd.com/read/29109028/enhancing-immunogenicity-of-antigens-through-sustained-intradermal-delivery-using-chitosan-microneedles-with-a-patch-dissolvable-design
#7
Mei-Chin Chen, Kuan-Ying Lai, Ming-Hung Ling, Chun-Wei Lin
Reducing the dosage required for vaccination is highly desirable, particularly in cases of epidemic emergencies. This study evaluated the potential of a chitosan microneedle (MN) system with a patch-dissolvable design for low-dose immunization. This system comprises antigen-loaded chitosan MNs and a hydrophilic polyvinyl alcohol/polyvinyl pyrrolidone supporting array patch, which provides extra strength to achieve complete MN insertion and then quickly dissolves in the skin to reduce patch-induced skin irritation...
November 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29107057/rapid-fabrication-of-microneedles-using-magnetorheological-drawing-lithography
#8
Zhipeng Chen, Lei Ren, Jiyu Li, Lebin Yao, Yan Chen, Bin Liu, Lelun Jiang
Microneedles are micron-sized needles that are widely applied in biomedical fields owing to their painless, minimally invasive, and convenient operation. However, most microneedle fabrication approaches are costly, time consuming, involve multiple steps, and require expensive equipment. In this study, we present a novel magnetorheological drawing lithography (MRDL) method to efficiently fabricate microneedle, bio-inspired microneedle, and molding-free microneedle array. With the assistance of an external magnetic field, the 3D structure of a microneedle can be directly drawn from a droplet of curable magnetorheological fluid...
October 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29103820/an-overview-of-the-biology-of-platelet-rich-plasma-and-microneedling-as-potential-treatments-for-alopecia-areata
#9
REVIEW
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for...
November 3, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29103509/physicochemical-study-of-ascorbic-acid-2-glucoside-loaded-hyaluronic-acid-dissolving-microneedles-irradiated-by-electron-beam-and-gamma-ray
#10
Suyong Kim, Jeongwon Lee, F Lahiji Shayan, Seohyun Kim, Inyoung Huh, Yonghao Ma, Huisuk Yang, Geonwoo Kang, Hyungil Jung
A dissolving microneedle (DMN) patch encapsulated with ascorbic acid 2-glucoside (AA2G) in a needle-shaped hyaluronic acid (HA) backbone was fabricated and sterilized by electron beam (e-beam, 5-40kGy) and gamma ray (γ-ray, 5-30kGy). DMN structures maintained their morphologies and fracture force regardless of e-beam and γ-ray irradiation doses. Both e-beam (40kGy) and γ-ray (20 and 30kGy) met the product sterility requirements for cosmetics and vaccines; however, γ-ray irradiation significantly degraded the encapsulated AA2G, while e-beam maintained AA2G activity...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29089253/use-of-a-monopolar-microneedle-device-in-a-transconjunctival-retroseptal-approach
#11
Thomas Gander, Claudio Rostetter, Michael Blumer, Maximilian Wagner, Paul Schumann, Daniel B Wiedemeier, Martin Rücker, Harald Essig
Transconjunctival approach is a standard procedure to address fractures of orbit and the infraorbital rim. Modifications such as transcaruncular or lateral canthal widening allow for extended orbital wall exposure. Especially concerning aesthetics, the transconjunctival approach shows benefits compared to the transcutaneous incisions, such as the transciliary and infraorbital access. Moreover, transconjunctival approach is favored in the literature concerning lid retraction. Monopolar devices have become popular in surgery in the past decades because of good depth control and simultaneous hemostasis with consequently improved overview...
September 30, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29089121/influenza-intradermal-vaccine-soluble-microneedles-a-patch-a-solution
#12
Antoni Trilla
No abstract text is available yet for this article.
October 28, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29074440/microarray-patches-potentially-useful-delivery-systems-for-long-acting-nanosuspensions
#13
REVIEW
Ryan F Donnelly, Eneko Larrañeta
Long-acting drug nanosuspension formulations are coming to the fore as controlled release strategies for several medical conditions and as a preventative measure against HIV infection. However, such delivery systems must, by necessity, be given by hypodermic injection, typically into muscle. This poses problems for patients who are needle-phobic, given that injections have to be administered on a weekly or monthly basis. Needle-stick injuries, inappropriate reuse of needles, and poor disposal practices are major challenges in developing countries...
October 23, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29072375/efficacy-of-microneedling-with-70-glycolic-acid-peel-vs-microneedling-alone-in-treatment-of-atrophic-acne-scars-a-randomized-controlled-trial
#14
Shiwangi Rana, Vibhu Mendiratta, Ram Chander
BACKGROUND: Microneedling with dermaroller and glycolic acid peels is commonly used for treatment of acne scars. OBJECTIVE: To compare efficacy of microneedling alone versus combination of microneedling with serial 70% glycolic acid peel in management of atrophic acne scars. METHODS & MATERIALS: Sixty patients with atrophic acne scars were randomized into group 1 receiving microneedling at 0, 6, and 12 weeks and group 2 receiving microneedling at 0, 6, and 12 weeks along with 70% glycolic acid peel at 3, 9, and 15 weeks...
October 26, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29069980/immunotherapeutic-effect-of-bcg-polysaccharide-nucleic-acid-powder-on-mycobacterium-tuberculosis-infected-mice-using-microneedle-patches
#15
Qinying Yan, Houming Liu, Zhigang Cheng, Yun Xue, Zhide Cheng, Xuyong Dai, Wanshui Shan, Fan Chen
Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunotherapeutic effects exist. Here, BCG-PSN powder was applied directly to the skin to evaluate the immunotherapeutic effects on mice infected with Mycobacterium tuberculosis (MTB). In total, 34 μg of BCG-PSN powder could be loaded into a microneedle patch (MNP)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29068445/mos2-pt-nanocomposite-functionalized-microneedle-for-real-time-monitoring-of-hydrogen-peroxide-release-from-living-cells
#16
Jin-Xiu Zhou, Li-Na Tang, Fan Yang, Feng-Xia Liang, Hua Wang, Yu-Tao Li, Guo-Jun Zhang
This work describes the adaptive use of a conventional stainless steel acupuncture needle as the electrode substrate for construction of a molybdenum disulfide (MoS2) and platinum nanoparticles (PtNPs) layer-modified microneedle sensor for real-time monitoring of hydrogen peroxide (H2O2) release from living cells. To construct the nanocomposite-functionalized microneedle, the needle surface was first coated with a gold film by ion sputtering to enhance the conductivity. Subsequently, an electrochemical deposition method was successfully employed to deposit MoS2 nanosheet and Pt nanoparticles on the needle tip as the sensing interface...
October 25, 2017: Analyst
https://www.readbyqxmd.com/read/29062646/calcium-hydroxylapatite-combined-with-microneedling-and-ascorbic-acid-is-effective-for-treating-stretch-marks
#17
Gabriela Casabona, Paula Marchese
BACKGROUND: Stretch marks can have a negative psychological impact on some individuals. Methods are available for treating stretch marks, but high-quality evidence supporting their use is limited. We treat stretch marks using injections of diluted calcium hydroxylapatite (CaHA, Radiesse) filler combined with microneedling and topical ascorbic acid. This retrospective study evaluated the effectiveness of this combined therapy. METHODS: Subjects presented with red (n = 25) or white (n = 10) striae on their buttocks, thighs, knees, abdomen, and breasts...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29060670/finite-element-modelling-and-preliminary-validation-of-microneedle-based-electrodes-for-enhanced-tissue-electroporation
#18
Ruth Houlihan, Konstantin Grygoryev, Zhenfei Ning, John Williams, Tom Moore, Conor O'Mahony
This paper investigates the use of microneedle-based electrodes for enhanced testis electroporation, with specific application to the production of transgenic mice. During the design phase, finite-element software has been used to construct a tissue model and to compare the relative performance of electrodes employing a) conventional flat plates, b) microneedle arrays, and c) invasive needles. Results indicate that microneedle-based electrodes can achieve internal tissue field strengths which are an order of magnitude higher than those generated using conventional flat electrodes, and which are comparable to fields produced using invasive needles...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059842/injection-moulded-microneedle-sensor-for-real-time-wireless-ph-monitoring
#19
Khalid B Mirza, Claudio Zuliani, Benjamin Hou, Fu Siong Ng, Nicholas S Peters, Christofer Toumazou
This paper describes the development of an array of individually addressable pH sensitive microneedles using injection moulding and their integration within a portable device for real-time wireless recording of pH distributions in biological samples. The fabricated microneedles are subjected to gold patterning followed by electrodeposition of iridium oxide to sensitize them to 0.07 units of pH change. Miniaturised electronics suitable for the sensors readout, analog-to-digital conversion and wireless transmission of the potentiometric data are embodied within the device, enabling it to measure real-time pH of soft biological samples such as muscles...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058002/a-microfluidic-microinjector-for-toxicological-and-developmental-studies-in-drosophila-embryos
#20
Reza Ghaemi, Pouya Arefi, Ana Stosic, Meryl Acker, Qanber Raza, J Roger Jacobs, Ponnambalam Ravi Selvaganapathy
Microinjection is an established and reliable method to deliver biological reagents such as transgenic constructs and drugs, to specific locations inside organisms such as the Drosophila embryo and C. elegans worm. In this paper, a simple compliant mechanism based PDMS-microinjection system has been demonstrated. Unlike conventional microinjectors, this unique system could allow one to precisely insert a long taper microneedle laterally and at various positions inside the length of the Drosophila embryo (up to 250 μm) with the resolution of 5 μm...
November 7, 2017: Lab on a Chip
keyword
keyword
62704
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"