Esther Garde, Laura Ramírez, Laura Corvo, José C Solana, M Elena Martín, Víctor M González, Carlos Gómez-Nieto, Aldina Barral, Manoel Barral-Netto, José M Requena, Salvador Iborra, Manuel Soto
Different members of intracellular protein families are recognized by the immune system of the vertebrate host infected by parasites of the genus Leishmania . Here, we have analyzed the antigenic and immunogenic properties of the Leishmania eIF2 and eIF2B translation initiation factors. An in silico search in Leishmania infantum sequence databases allowed the identification of the genes encoding the α, β, and γ subunits and the α, β, and δ subunits of the putative Leishmania orthologs of the eukaryotic initiation factors F2 (LieIF2) or F2B (LieIF2B), respectively...
2018: Frontiers in Cellular and Infection Microbiology